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Rhabdomyolysis After Performing Blood Flow Restriction Training: A Case Report. | Tabata, S, Suzuki, Y, Azuma, K, and Matsumoto, H. Rhabdomyolysis after performing blood flow restriction training: a case report. J Strength Cond Res 30(7): 2064-2068, 2016-Rhabdomyolysis is a serious and potentially life-threatening condition related to resistance training. Despite numerous reports of low-intensity bl... | ['Adult', 'Humans', 'Male', 'Resistance Training', 'Rhabdomyolysis'] | 26,677,831 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500.387.875', 'E02.779.483.875', 'E02.831.535.483.875', 'G11.427.410.698.277.311.750', 'I03.350.311.750'], ['C05.651.807']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Histochemical mapping of certain enzymes in few fresh water teleosts. I. Acid phosphatase. | A detailed investigation of the distribution pattern of acid phosphatase in the different parts of alimentary canal and associated glands of Colisa fasciatus, Macrognathus aculeatus, Notopterus notopterus and Nandus nandus has been made. Though this enzyme shows its hydrolytic activity in all the parts of the digestive... | ['Acid Phosphatase', 'Animals', 'Cecum', 'Esophagus', 'Fishes', 'Intestines', 'Liver', 'Pancreas', 'Rectum', 'Stomach'] | 1,023,551 | [['D08.811.277.352.650.025'], ['B01.050'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['A03.556.875.500'], ['B01.050.150.900.493'], ['A03.556.124'], ['A03.620'], ['A03.734'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['A03.556.875.875']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Flexion contracture of the thumb: a malignant etiology. | A patient was first seen with a flexion deformity of the thumb interphalangeal joint that was initially diagnosed and treated as traumatic in origin. A painful forearm soft tissue mass was ultimately discovered; biopsy of the flexor pollicis longus tendon showed metastatic adenocarcinoma. Extensive evaluation failed to... | ['Adenocarcinoma', 'Breast Neoplasms', 'Contracture', 'Female', 'Finger Joint', 'Forearm', 'Humans', 'Middle Aged', 'Muscular Diseases', 'Thumb'] | 2,754,210 | [['C04.557.470.200.025'], ['C04.588.180', 'C17.800.090.500'], ['C05.550.323', 'C05.651.197'], ['A02.835.583.405.350'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.651', 'C10.668.491'], ['A01.378.800.667.430.705']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Peritoneal function and adequacy calculations: current programs versus PD Adequest 2.0. | OBJECTIVE: Our current programs (CPs) were compared to PD Adequest 2.0 (PD-A) for calculations of peritoneal membrane transport and dialysis adequacy.DESIGN: Thirty peritoneal equilibration tests (PETs) and 24-hour balances (24hBs) were conducted and calculated using our CPs and PD-A.PATIENTS AND METHODS: Thirty hospit... | ['Adult', 'Aged', 'Biological Transport, Active', 'Blood Glucose', 'Creatinine', 'Diagnosis, Computer-Assisted', 'Female', 'Humans', 'Male', 'Middle Aged', 'Peritoneal Dialysis', 'Peritoneum', 'Renal Insufficiency', 'Reproducibility of Results', 'Software', 'Time Factors', 'Urea', 'Water-Electrolyte Imbalance'] | 12,227,398 | [['M01.060.116'], ['M01.060.116.100'], ['G03.143.310'], ['D09.947.875.359.448.500'], ['D03.383.129.308.207'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.870.300.650', 'E02.912.800.650'], ['A01.923.047.025.600', 'A10.615.789.596'], ['C12.777.419.78... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Destructive ocular myiasis in a noncompromised host. | A case of destructive ocular myiasis resulting in complete loss of the globe in two days time is documented. To the best of our knowledge this is the first report of such a severe involvement in a healthy and non-compromised host. Mechanical removal and good local hygiene helped heal the wound. The larvae were isolated... | ['Aged', 'Aged, 80 and over', 'Animals', 'Blindness', 'Eye Diseases', 'Female', 'Humans', 'Larva', 'Myiasis'] | 2,086,473 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B05.500.500', 'G07.345.500.550.500.500'], ['C01.610.858.211.503']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Colleges of continuing education. | Educators should now take over the haphazard pattern that has envolved in continuing education and formalize it in colleges of continuing education. Most dentists in America are now oriented to the concept of continuing education, and this large group could be the nidus for the promotion of colleges of continuing educ... | ['Curriculum', 'Education, Dental, Continuing', 'Faculty, Dental', 'Schools, Dental', 'United States'] | 266,519 | [['I02.158'], ['I02.358.212.249', 'I02.358.274.316'], ['M01.526.485.360', 'M01.526.702.250.273', 'N02.360.360'], ['I02.783.495.481'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Spatial regulation of expanded transcription in the Drosophila wing imaginal disc. | Growth and patterning are coordinated during development to define organ size and shape. The growth, proliferation and differentiation of Drosophila wings are regulated by several conserved signaling pathways. Here, we show that the Salvador-Warts-Hippo (SWH) and Notch pathways converge on an enhancer in the expanded (... | ['Animals', 'Drosophila Proteins', 'Drosophila melanogaster', 'Imaginal Discs', 'Membrane Proteins', 'Signal Transduction', 'Transcription, Genetic', 'Wings, Animal'] | 30,063,727 | [['B01.050'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['A13.518'], ['D12.776.543'], ['G02.111.820', 'G04.835'], ['G02.111.873', 'G05.297.700'], ['A13.395.823']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of a short-term high-intensity circuit training program on work capacity, body composition, and blood profiles in sedentary obese men: a pilot study. | The objective of this study was to determine how a high-intensity circuit-training (HICT) program affects key physiological health markers in sedentary obese men. Eight obese (body fat percentage >26%) males completed a four-week HICT program, consisting of three 30-minute exercise sessions per week, for a total of 6 h... | ['Adult', 'Blood Pressure', 'Body Composition', 'Cholesterol', 'Circuit-Based Exercise', 'Heart Rate', 'Humans', 'Insulin', 'Lipoproteins, HDL', 'Lipoproteins, LDL', 'Obesity', 'Pilot Projects', 'Resistance Training', 'Triglycerides', 'Work Capacity Evaluation'] | 24,707,476 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G11.427.410.698.277.311.125', 'I03.350.311.125'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Direct stent implantation in acute coronary syndrome. | OBJECTIVE: To evaluate the feasibility and safety of direct stenting and to compare it with conventional implantation techniques in patients with acute coronary syndrome (ACS).METHODS: A total of 145 patients were divided into two arms based on the stenting technique used: group I (n = 71) = direct stenting without pre... | ['Acute Disease', 'Aged', 'Angioplasty, Balloon, Coronary', 'Coronary Angiography', 'Electrocardiography', 'Feasibility Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Myocardial Revascularization', 'Stents', 'Treatment Outcome'] | 12,042,621 | [['C23.550.291.125'], ['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', '... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Aneurysmal bone cyst of the ilium associated with pregnancy. | A 19-yr-old primigravida presented with a back mass which was found to originate from the right ilium and was associated with oblique fetal lie. Elective caesarean section and excision of the mass were done. Histologically, the lesion proved to be an aneurysmal bone cyst. Review of bone tumors associated with pregnancy... | ['Adolescent', 'Bone Cysts', 'Cesarean Section', 'Female', 'Humans', 'Ilium', 'Infant, Newborn', 'Pregnancy', 'Pregnancy Complications'] | 3,817,267 | [['M01.060.057'], ['C04.182.089', 'C05.116.070'], ['E04.520.252.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.825.434'], ['M01.060.703.520'], ['G08.686.784.769'], ['C13.703']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. | The pattern and the sequence of tumour necrosis factor-alpha (TNF alpha) induced cell death in the acute T-lymphoblastic leukaemic cell line CCRF-CEM and its vinblastine-resistant subline CEM/VLB100 have been studied. Previously, we found that the CEM/VLB100 cell line was more sensitive to TNF alpha-induced killing tha... | ['Apoptosis', 'Autophagy', 'Humans', 'Leukemia-Lymphoma, Adult T-Cell', 'Lysosomes', 'Microscopy, Electron', 'Mitochondria', 'Tumor Cells, Cultured', 'Tumor Necrosis Factor-alpha'] | 9,332,326 | [['G04.146.954.035'], ['G04.011'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428.580.100', 'C15.604.515.560.575.100', 'C20.683.515.528.582.100'], ['A11.284.430.214.190.875.190.550'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['A11.251.860'], ['D12.6... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. | BACKGROUND AND AIMS: Hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC), compared with genotype B. This study aims to investigate whether HBV genotypes influence the clinicopathologic features and long-term prognosis of patients after curative resection of HCC.METHOD... | ['Adult', 'Age Factors', 'Aged', 'Carcinoma, Hepatocellular', 'Digestive System Surgical Procedures', 'Female', 'Follow-Up Studies', 'Genetic Predisposition to Disease', 'Genotype', 'Hepatitis B', 'Hepatitis B virus', 'Humans', 'Liver Cirrhosis', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', '... | 15,017,634 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E04.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.3... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Wolbachia infection in the newly described Ecuadorian sand flea, Tunga trimamillata. | Wolbachia pipientis is an intracellular endosymbiont producing reproductive alterations in its hosts. This bacterium have been reported in many arthropods and nematodes. By PCR amplification and sequencing of the 16S rDNA and ftsZ genes we have identified a Wolbachia strain in the newly described sand-flea, Tunga trima... | ['Animals', 'Bacterial Proteins', 'Cytoskeletal Proteins', 'DNA, Bacterial', 'DNA, Ribosomal', 'Female', 'Genotype', 'Host-Parasite Interactions', 'Male', 'Molecular Sequence Data', 'Phenotype', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Reproduction', 'Sequence Alignment', 'Sex Ratio', 'Siphonap... | 15,491,544 | [['B01.050'], ['D12.776.097'], ['D12.776.220'], ['D13.444.308.212'], ['D13.444.308.475'], ['G05.380'], ['G16.527.200.400'], ['L01.453.245.667'], ['G05.695'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500'], ['D13.444.735.686.670'], ['G08.686.784'], ['E05.393.751'], ['G05.815', 'I01.240.800.815', 'N01.224... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Morphometric analysis of involuting bovine mammary tissue after 21 or 42 days on non-suckling. | Mammary gland involution was morphologically evaluated 21 or 42 d after prevention of suckling of one udder half in 10 crossbred beef cows. Parenchymal tissue was taken from lower, middle and upper zones of each quarter from the teat to the ventral body wall. Udder halves, trimmed of extraparenchymal tissue, were weigh... | ['Animals', 'Cattle', 'Cell Count', 'DNA', 'Epithelial Cells', 'Epithelium', 'Female', 'Lactation', 'Mammary Glands, Animal', 'Organ Size'] | 2,262,413 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D13.444.308'], ['A11.436'], ['A10.272'], ['G08.686.523', 'G08.686.702.500'], ['A10.336.482', 'A13.589'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Double-degree oral and maxillofacial surgeons: was it worth it? | A survey was conducted of oral and maxillofacial surgeons with double degrees who are members of the American Association of Oral and Maxillofacial Surgeons (AAOMS). The survey consisted of questions related to obtaining their MD degree; comparing the difficulty of medical school versus dental school and oral and maxil... | ['Education, Medical', 'Humans', 'Surgery, Oral', 'Surveys and Questionnaires'] | 3,171,747 | [['I02.358.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E06.892', 'H02.163.876.886'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Risk factor stratification after simultaneous liver and colorectal resection for synchronous colorectal metastasis. | BACKGROUND/AIM: This study was conducted to devise a prognostic model for patients undergoing simultaneous liver and colorectal resection.MATERIALS AND METHODS: A retrospective analysis was performed on 138 colorectal patients who underwent simultaneous liver and colorectal resection between September 1994 and Septembe... | ['Adult', 'Aged', 'Chemotherapy, Adjuvant', 'Colon', 'Colorectal Neoplasms', 'Combined Modality Therapy', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Hepatectomy', 'Humans', 'Liver', 'Liver Neoplasms', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Ne... | 17,909,846 | [['M01.060.116'], ['M01.060.116.100'], ['E02.186.170', 'E02.319.170'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Inadequate blood pressure control in patients with type 2 diabetes mellitus]. | BACKGROUND: There is evidence indicating that blood pressure control is more effective in reducing macrovascular complications of diabetes mellitus (DM) than glycemic control. However, the reduction in BP to levels recommended by international guidelines is difficult in clinical practice.OBJECTIVE: To assess the percen... | ['Blood Pressure', 'Comorbidity', 'Diabetes Mellitus, Type 2', 'Epidemiologic Methods', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Reference Values', 'Time Factors'] | 20,428,720 | [['E01.370.600.875.249', 'G09.330.380.076'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['E05.978.810'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determination of kinetic constants for the interaction between the platelet glycoprotein IIb-IIIa and fibrinogen by means of surface plasmon resonance. | The binding reaction between purified human platelet glycoprotein IIb-IIIa and fibrinogen was investigated by real-time measurements using the surface-plasmon-resonance sensor technology. In these experiments, either glycoprotein IIb-IIIa or fibrinogen was immobilized on a sensor surface. The time-dependent change in s... | ['Amino Acid Sequence', 'Binding Sites', 'Binding, Competitive', 'Fibrinogen', 'Humans', 'In Vitro Techniques', 'Kinetics', 'Ligands', 'Molecular Sequence Data', 'Oligopeptides', 'Platelet Membrane Glycoproteins', 'Solubility', 'Thermodynamics'] | 7,867,623 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lipids favoring inverted phase enhance the ability of aerolysin to permeabilize liposome bilayers. | Channel formation by the bacterial toxin aerolysin follows oligomerization of the protein to produce heptamers that are capable of inserting into lipid bilayers. How insertion occurs is not understood, not only for aerolysin but also for other proteins that can penetrate membranes. We have studied aerolysin channel for... | ['Animals', 'Bacterial Toxins', 'Cattle', 'Egg Yolk', 'Ion Channels', 'Lipid Bilayers', 'Lipid Metabolism', 'Lipids', 'Liposomes', 'Lysophosphatidylcholines', 'Permeability', 'Phosphatidylcholines', 'Pore Forming Cytotoxic Proteins'] | 11,087,349 | [['B01.050'], ['D23.946.123'], ['B01.050.150.900.649.313.500.380.271'], ['A16.690.325', 'G07.203.300.470.800', 'J02.500.470.800'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D10.570.510', 'J01.637.087.500.510'], ['G03.458'], ['D10'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Sleep maintenance insomnia complaints predict poor CPAP adherence: A clinical case series. | BACKGROUND: Although CPAP is a highly efficacious treatment for obstructive sleep apnea (OSA), low adherence presents a significant challenge for sleep medicine clinicians. The present study aimed to evaluate the relationship between insomnia symptoms and CPAP use. We hypothesized that pre-treatment insomnia complaints... | ['Adult', 'Aged', 'Continuous Positive Airway Pressure', 'Female', 'Follow-Up Studies', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Patient Compliance', 'Predictive Value of Tests', 'Retrospective Studies', 'Risk Factors', 'Sleep Apnea, Obstructive', 'Sleep Initiation and Maintenance Disorders', 'Treatment Out... | 20,673,741 | [['M01.060.116'], ['M01.060.116.100'], ['E02.041.625.790.259', 'E02.880.820.790.259'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis and spectroscopic properties of copper(II) complexes derived from thiophene-2-carbaldehyde thiosemicarbazone. Structure and biological activity of [Cu(C6H6N3S2)2]. | The synthesis, structure and spectroscopic properties on complexes with the formula [Cu(Lm)2] (1) and Cu(NO3)2(HLm)2 (2), where HLm = thiophene-2-carbaldehyde thiosemicarbazone, have been developed. The molecular structure of compound 1 consists of monomeric entities. The copper(II) ions exhibit distorted square-planar... | ['Animals', 'Copper', 'Crystallography, X-Ray', 'Electron Spin Resonance Spectroscopy', 'Friend murine leukemia virus', 'Glutathione', 'Leukemia, Experimental', 'Melanoma, Experimental', 'Models, Molecular', 'Retroviridae Infections', 'Spectrophotometry', 'Structure-Activity Relationship', 'Sulfhydryl Compounds', 'Thio... | 10,402,676 | [['B01.050'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.309.742.225'], ['E05.196.867.519.274'], ['B04.613.807.375.525.225', 'B04.820.650.375.525.225'], ['D12.644.456.448'], ['C04.557.337.372', 'C04.619.531', 'E05.598.500.496.500'], ['C04.557.465.625.650.510.525', 'C04.557.580.625.650.510.525'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides. | Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino acid substitutions is to cite the wild-type amino acid,... | ['Antifungal Agents', 'Drug Resistance, Fungal', 'Fungal Proteins', 'Fungicides, Industrial', 'Mutation', 'Terminology as Topic'] | 27,148,866 | [['D27.505.954.122.136'], ['G06.225.383', 'G07.690.773.984.269.383'], ['D12.776.354'], ['D27.720.031.700.288', 'D27.888.723.288'], ['G05.365.590'], ['L01.559.598.400']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Endocrine manipulation of meningiomas with medroxyprogesterone acetate. Effect of MPA on growth of primary meningioma cells in monolayer tissue culture. | Intracranial meningiomas from patients treated with medroxyprogesterone acetate as well as from untreated patients were studied in monolayer tissue culture with trials of in vitro hormonal modulation with medroxyprogesterone acetate. The following conclusions were drawn from investigations which comprise 37 cell cultur... | ['Antigens, Surface', 'Cell Division', 'Culture Techniques', 'Endocrine Glands', 'Humans', 'Immunohistochemistry', 'Ki-67 Antigen', 'Medroxyprogesterone', 'Medroxyprogesterone Acetate', 'Meningeal Neoplasms', 'Meningioma', 'Receptors, Progesterone', 'Tumor Cells, Cultured'] | 2,522,246 | [['D23.050.301'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.481.500'], ['A06.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix. | To analyze relevant factors and their effects on neoplastic progression in cervical carcinoma, a panel of genetic markers was studied. Paraffin-embedded tissue sections were obtained from 37 patients with carcinoma of the uterine cervix, 14 noninvasive squamous cell carcinomas (NISCCs), and 23 invasive squamous cell ca... | ['Acid Anhydride Hydrolases', 'Adaptor Proteins, Signal Transducing', 'Adult', 'Aged', 'Base Pair Mismatch', 'Carcinoma in Situ', 'Carcinoma, Squamous Cell', 'Carrier Proteins', 'DNA Repair', 'DNA-Binding Proteins', 'Female', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'MutL Protein Homolog 1', 'MutS Homolog 2 Pro... | 10,999,751 | [['D08.811.277.040'], ['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['M01.060.116'], ['M01.060.116.100'], ['G05.365.590.060'], ['C04.557.470.200.240'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D12.776.157'], ['G02.111.222', 'G05.219'], ['D12.776.260'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Lipid concentrations in liver cell fractions in the rat in diet induced obesity]. | The changes of lipid parameters induced in male Wistar rats by feeding a high-fat diet for several weeks were studied in cell fractions of the liver. For this purpose subcellular fractionations of liver tissue from 12-week-old animals receiving food containing, respectively, 3% fat (controls) and 50% fat, were performe... | ['Animals', 'Cholesterol', 'Cholesterol Esters', 'Dietary Fats', 'Fatty Liver', 'Humans', 'Lipid Metabolism', 'Liver', 'Male', 'Microscopy, Electron', 'Microsomes, Liver', 'Mitochondria, Liver', 'Obesity', 'Phospholipids', 'Rats', 'Rats, Inbred Strains', 'Triglycerides'] | 7,148,276 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['C06.552.241'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458'], ['A03.620'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Live imaging of drug responses in the tumor microenvironment in mouse models of breast cancer. | The tumor microenvironment plays a pivotal role in tumor initiation, progression, metastasis, and the response to anti-cancer therapies. Three-dimensional co-culture systems are frequently used to explicate tumor-stroma interactions, including their role in drug responses. However, many of the interactions that occur i... | ['Animals', 'Female', 'Mammary Neoplasms, Experimental', 'Mice', 'Mice, Transgenic', 'Microscopy, Confocal', 'Subcellular Fractions', 'Tumor Microenvironment'] | 23,542,634 | [['B01.050'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['E01.370.350.515.395', 'E05.595.395'], ['A11.284.835'], ['G04.366.500']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Central venous oxygen saturation during hypovolaemic shock in humans. | We compared central venous oxygen saturation and central venous pressure (CVP) as indices of the effective blood volume during 50 degrees head-up tilt (anti-Trendelenburg's position) induced hypovolaemic shock in eight healthy subjects. Head-up tilt increased thoracic electrical impedance from 31 (28-36) (median and ra... | ['Adult', 'Blood Pressure', 'Cardiac Output', 'Cardiography, Impedance', 'Central Venous Pressure', 'Heart Rate', 'Humans', 'Oxygen', 'Posture', 'Shock', 'Vascular Resistance'] | 8,451,602 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E01.370.370.380.160', 'E01.370.370.610.610.200'], ['G09.330.380.076.732.336'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.185.550', 'D01.362.670'], ['G1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Resistance of Nocardia asteroides to oxygen-dependent killing by neutrophils. | Nocardia asteroides resists killing by neutrophils despite the occurrence of the oxidative metabolic burst when the organism is phagocytosed. In a study of the apparent resistance of N asteroides to oxygen-dependent killing by neutrophils, this organism and (for comparison) Staphylococcus aureus were exposed to metabol... | ['Catalase', 'Humans', 'Hydrogen Peroxide', 'Microbial Sensitivity Tests', 'Neutrophils', 'Nocardia asteroides', 'Oxidation-Reduction', 'Oxygen', 'Staphylococcus aureus', 'Superoxide Dismutase', 'Zymosan'] | 6,355,320 | [['D08.811.682.732.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spike coding during osmotic stimulation of the rat supraoptic nucleus. | Novel measures of coding based on interspike intervals were used to characterize the responses of supraoptic cells to osmotic stimulation. Infusion of hypertonic NaCl in vivo increased the firing rate of continuous (putative oxytocin) cells (Wilcoxon z= 3.84, P= 0.001) and phasic (putative vasopressin) cells (z= 2.14, ... | ['Action Potentials', 'Animals', 'Biological Clocks', 'Cells, Cultured', 'Computer Simulation', 'Information Storage and Retrieval', 'Male', 'Membrane Potentials', 'Models, Neurological', 'Osmotic Pressure', 'Rats', 'Rats, Wistar', 'Supraoptic Nucleus', 'Water-Electrolyte Balance'] | 16,166,154 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['G07.180.562.094'], ['A11.251'], ['L01.224.160'], ['L01.313.500.750.280', 'L01.470'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395.642'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['B01.050.150.900.649.313.992.635.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim. | An ethyl acetate extract from the barks of the ethnic Chinese medicine Daphne tangutica Maxim. exhibited antihepatocellular carcinoma activity against HepG2 and Hep3B cell lines. By using high-performance liquid chromatography based activity profiling in combination with offline liquid chromatography with mass spectrom... | ['Antineoplastic Agents, Phytogenic', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Chromatography, High Pressure Liquid', 'Dose-Response Relationship, Drug', 'Drug Discovery', 'Drug Screening Assays, Antitumor', 'Drugs, Chinese Herbal', 'HEK293 Cells', 'Humans', 'Magnetic Resonance Spectroscopy', 'Mass S... | 27,062,225 | [['D27.505.954.248.179'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['E05.196.181.400.300'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['D... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines. | The activity of an alpha 2,6 sialyltransferase acting on N-acetyllactosaminic sequences (alpha 2,6 ST E.C. 2.4.99.1) has previously been found to be increased in 90% of human colon cancer specimens. In the present study, the alpha 2,6 ST activity of 6 human colon cancer cell lines grown in culture was compared with tha... | ['Amino Sugars', 'Animals', 'Colonic Neoplasms', 'Fluorescein-5-isothiocyanate', 'Humans', 'Lectins', 'Male', 'Mice', 'Mice, Nude', 'Plant Lectins', 'Rats', 'Ribosome Inactivating Proteins', 'Sialyltransferases', 'Transplantation, Heterologous', 'Tumor Cells, Cultured'] | 1,730,528 | [['D09.067'], ['B01.050'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275.400', 'D04.711.347.400'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Malformations of neocortical development: magnetic resonance imaging correlates. | Malformations of cortical development are a significant cause of epilepsy in adults and of developmental delay and epilepsy in children. Magnetic resonance imaging allows many of these malformations to be detected noninvasively. In the past year, the major work in this area has been aimed at improved detection of small... | ['Cerebral Cortex', 'Epilepsy', 'Humans', 'Magnetic Resonance Imaging'] | 8,782,979 | [['A08.186.211.200.885.287.500'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induced parturition in cattle. 1. Clinical studies. | Parturition was induced in 17 Friesland heifers to decrease the possible occurrence of dystocia. The heifers were given 39 mg dexamethasone intra-muscularly on the 267th day of pregnancy and were observed for signs of impending parturition. The time of foetal membrane expulsion was noted. Parturition occurred on an ave... | ['Animals', 'Cattle', 'Cattle Diseases', 'Dexamethasone', 'Estrus', 'Female', 'Fertility', 'Labor, Induced', 'Obstetric Labor Complications', 'Placenta', 'Pregnancy'] | 940,094 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G08.686.195.500'], ['G08.686.210'], ['E04.520.252.968'], ['C13.703.420'], ['A16.710'], ['G08.686.784.769']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nmethyl-N-nitrosourea (MNU) induces papillary thyroid tumours which lack ras gene mutations in the hermaphroditic fish Rivulus marmoratus. | To investigate the patterns of alkylating agent-induced tumour formation, 40 fish (Rivulus marmoratus) were exposed to N-methyl-N-nitrosourea (MNU) at 50 ppm in 10 mM Hepes-buffered synthetic seawater for 2 h. Tumour incidence 4 months after exposure was approximately 95%, and mainly papillary thyroid tumours were indu... | ['Alkylating Agents', 'Animals', 'Blotting, Northern', 'Blotting, Southern', 'Carcinoma, Papillary', 'DNA Mutational Analysis', 'DNA, Neoplasm', 'Fishes', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Neoplastic', 'Genes, fos', 'Genes, myc', 'Genes, ras', 'Genes, src', 'Hermaphroditic Organism... | 10,607,373 | [['D27.505.519.124', 'D27.888.569.035'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['E05.393.760.700.300'], ['D13.444.308.425'], ['B01.050.150.900.493'], ['G05.308.320'], ['G05.308.370'], ['G... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
More to teamwork than knowledge, skill and attitude. | OBJECTIVE: To assess whether team performance in simulated eclampsia is related to the knowledge, skills and attitudes of individual team members.DESIGN: Cross-sectional analysis of data from the Simulation and Fire Drill Evaluation randomised controlled trial.SETTING: Six secondary and tertiary maternity units in sout... | ['Anticonvulsants', 'Clinical Competence', 'Cross-Sectional Studies', 'Eclampsia', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Interprofessional Relations', 'Magnesium Sulfate', 'Medical Staff, Hospital', 'Patient Care Team', 'Pregnancy', 'Prenatal Care', 'Surveys and Questionnaires'] | 20,618,313 | [['D27.505.954.427.080'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C13.703.395.124'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['D01.524.550', 'D01.875.800.800.... | ['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Activated protein C resistance in antiphospholipid thrombosis syndrome. | OBJECTIVE: To explore the correlation between antiphospholipid antibodies (APA), activated protein C resistance (APCR) and antiphospholipid thrombosis (APL-T) syndrome and further investigate the mechanism of thrombosis in APL-T syndrome.METHODS: ELISA, PTT-LA and APTT +/- APC methods were used to detect anticardiolipi... | ['Activated Protein C Resistance', 'Adult', 'Antiphospholipid Syndrome', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Lupus Coagulation Inhibitor', 'Male', 'Middle Aged', 'Thrombosis'] | 11,776,051 | [['C15.378.100.100.037', 'C15.378.100.141.036', 'C15.378.925.050', 'C16.320.099.037'], ['M01.060.116'], ['C20.111.197'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.323.210... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regional variations in stroke care in England, Wales and Northern Ireland: results from the National Sentinel Audit of Stroke. Royal College of Physicians Intercollegiate Stroke Working Party. | STUDY OBJECTIVE: To identify the variations between regions in England, Wales and Northern Ireland in the case-mix, organization and process of care for stroke.DESIGN: Retrospective audit of case notes and service organization.SETTING: Two hundred and ten Trust sites from 197 Trusts in 10 Health Regions in England, Wal... | ['Aged', 'Aged, 80 and over', 'Diagnosis-Related Groups', 'England', 'Female', 'Hospital Mortality', 'Hospital Units', 'Humans', 'Institutionalization', 'Length of Stay', 'Male', 'Medical Audit', 'Northern Ireland', 'Patient Discharge', 'Retrospective Studies', 'Stroke', 'Stroke Rehabilitation', 'Wales'] | 11,594,646 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['N03.219.521.710.305.200.080'], ['Z01.542.363.300'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['N02.278.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.415', 'N02.421.585.415'], ['E... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil. | Neuroinflammatory roles of central innate immunity in brain parenchyma are well-regarded in the progression of neurodegenerative disorders including Alzheimer's disease (AD), however, the roles of peripheral immunity in central nervous system (CNS) diseases are less clear. Here, we created a microfluidic environment of... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Antibodies, Neutralizing', 'Cell Line', 'Humans', 'Immunity, Innate', 'Inflammation', 'Microglia', 'Neurodegenerative Diseases', 'Neutrophils', 'Up-Regulation'] | 31,611,872 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.564'], ['C23.550.4... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A simplified approach to the anesthesia of porcine laparoscopic surgical subjects. | At a series of laparoscopic surgical workshops, 155 pigs were successfully anesthetised for up to 4 hours by using Profolol (Diprivan) as the anesthetic agent and without provision of positive pressure ventilation. On the basis of our findings, we believe this methodology presents a useful alternative to gaseous anesth... | ['Anesthesia', 'Animals', 'Infusions, Intravenous', 'Laparoscopy', 'Propofol', 'Swine', 'Time Factors'] | 8,231,091 | [['E03.155'], ['B01.050'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E01.370.388.250.520', 'E04.502.250.520'], ['D02.455.426.559.389.657.773'], ['B01.050.150.900.649.313.500.880'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Automated screening procedure using gas chromatography-mass spectrometry for identification of drugs after their extraction from biological samples. | A novel analytical screening procedure has been developed, using computer-controlled gas chromatography-mass spectrometry (GC-MS), to detect 120 drugs of interest to road safety. This paper describes GC-MS methodology suitable for use on extracts of biological origin, while extraction procedures will be the subject of ... | ['Drug Evaluation, Preclinical', 'Electronic Data Processing', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Liver', 'Pharmaceutical Preparations'] | 1,874,868 | [['E05.290.750', 'E05.337.550'], ['L01.224.085'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['D26']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
PTEN deletion is rare but often homogeneous in gastric cancer. | BACKGROUND AND AIM: Gastric carcinoma is the second most frequent cause of cancer-related death worldwide. As PTEN is a potential modifier of tumour response to trastuzumab, a recently approved therapy in metastatic HER2 positive gastric cancer, the existence of PTEN deletions in primary gastric cancer was investigated... | ['Adenocarcinoma', 'Aged', 'Biomarkers, Tumor', 'Chi-Square Distribution', 'Female', 'Gene Deletion', 'Genetic Predisposition to Disease', 'Germany', 'Hemizygote', 'Homozygote', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization, Fluorescence', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'PTEN Phosphohydrolas... | 22,639,407 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['D23.101.140'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['G05.365.590.762.320', 'G05.558.800.320'], ['C23.550.291.687.500', 'G05.380.355'], ['Z01.542.315'], ['G05.380.371'], ['G05.380.554'], ['B01.050.150.900.649.313.9... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. | Expression of proteins associated with immune function was investigated immunohistochemically in postmortem brain and spinal cord of patients with amyotrophic lateral sclerosis (ALS). Reactive microglia/macrophages displaying high levels of leukocyte common antigen (LCA), the immunoglobulin receptor Fc gamma R1, lympho... | ['Amyotrophic Lateral Sclerosis', 'Antigens, Surface', 'Brain', 'Cell Adhesion Molecules', 'Cell Count', 'Complement System Proteins', 'Glial Fibrillary Acidic Protein', 'Humans', 'Intercellular Adhesion Molecule-1', 'Leukocyte Count', 'Leukocytes', 'Nerve Tissue Proteins', 'Neuroglia', 'Neurons', 'Spinal Cord'] | 1,347,673 | [['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['D23.050.301'], ['A08.186.211'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D12.776.124.486.274'], ['D05.750.078.593.400'... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of nano/submicrometer yam and its benefits on collagen secretion from skin fibroblast cells. | Nano/submicrometer-scaled yam particles have been prepared by using media-milling. The particle size of media-milled yam was confirmed by the laser light scattering method and scanning electron microscopy. Influences of media-milled yam on skin fibroblast cells (WS1) were evaluated. The size reduction did not significa... | ['Cell Line', 'Collagen', 'Dioscorea', 'Fibroblasts', 'Humans', 'Microscopy, Electron, Scanning', 'Nanoparticles', 'Particle Size', 'Plant Extracts', 'Skin'] | 23,205,552 | [['A11.251.210'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.650.940.800.575.912.250.325.500'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512.600'], ['G02.712'], ['D20.215.784.500', 'D26.667'], ['A17.815']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
In vitro skin irritation testing: Improving the sensitivity of the EpiDerm skin irritation test protocol. | A skin irritation test (SIT) utilising a common protocol for two in vitro reconstructed human epidermal (RhE) models, EPISKIN and EpiDerm, was developed, optimised and evaluated as a replacement for the in vivo rabbit skin irritation test in an ECVAM-sponsored validation study. In 2007, both RhE models were recognised ... | ['Animal Testing Alternatives', 'Animals', 'European Union', 'Humans', 'Irritants', 'Keratinocytes', 'Rabbits', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Skin Irritancy Tests', 'Tissue Engineering', 'United States'] | 20,105,002 | [['E05.017.080.100'], ['B01.050'], ['I01.615.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.400', 'D27.888.569.300'], ['A11.409.500', 'A11.436.397'], ['B01.050.150.900.649.313.968.700'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Five-year diagnostic stability among adolescents in an inpatient psychiatric unit. | INTRODUCTION: In childhood, diagnoses made at the first admission to a psychiatric unit are frequently unstable and temporary. In this study, we examined the stability of DSM-IV-TR disorders and groups of disorders among adolescents followed-up for 5 years after hospitalization.METHOD: All inpatients admitted for the f... | ['Adolescent', 'Adult', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Follow-Up Studies', 'Hospitalization', 'Humans', 'Inpatients', 'Male', 'Mental Disorders', 'Patient Outcome Assessment', 'Quality of Life', 'Surveys and Questionnaires', 'Time Factors', 'Young Adult'] | 30,583,125 | [['M01.060.057'], ['M01.060.116'], ['L01.453.245.945.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['F03'], ['N04.761.559.590.399', 'N05.715.360.575.575.399'], ['I01.... | ['Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Effects of intracranial injection of transforming growth factor-beta relevant to central fatigue on the waking electroencephalogram of rats: comparison with effects of exercise. | To investigate the detailed actions of transforming growth factor-beta (TGF-beta) in the brain, which increase accompanied with continuity of exercise, the authors performed electroencephalogram (EEG) spectral analysis for 2 h after intracranial injection of TGF-beta in rats and compared with the effects of swimming ex... | ['Animals', 'Electroencephalography', 'Fatigue', 'Injections, Intraventricular', 'Male', 'Physical Conditioning, Animal', 'Rats', 'Rats, Sprague-Dawley', 'Transforming Growth Factor beta'] | 11,817,509 | [['B01.050'], ['E01.370.376.300', 'E01.370.405.245'], ['C23.888.369'], ['E02.319.267.530.550'], ['G11.427.410.698.277.280'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.644.276.374.687', 'D12.644.276.954.775', 'D12.776.467.374.687', 'D12.776.467.942.775', 'D23.529... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Should I stay or should I go? Career change and labor force separation among registered nurses in the U.S. | Efforts to retain nurses within the profession are critical for resolving the global nursing shortage, but very little research explores the phenomenon of nursing workforce attrition in the U.S. This study is the first to simultaneously investigate the timing of attrition through survival analysis, the exit path taken ... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Career Mobility', 'Employment', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nurses', 'Retirement', 'Sex Factors', 'Socioeconomic Factors', 'United States', 'Young Adult'] | 20,378,222 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N01.824.245.175', 'N01.824.547.330'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.485.650', 'N02.360.650'], ['I03.702'], ['N05.715.350.675', 'N06.850.490.875'], ... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of passive ultrasonic irrigation and manual dynamic irrigation on smear layer removal from root canals in a closed apex in vitro model. | AIM: To compare the effect of passive ultrasonic irrigation with manual dynamic irrigation on smear layer removal from root canals using a closed apex in vitro model.METHODS: The root canals of 45 freshly-extracted human single-rooted mandibular premolar teeth were prepared by the Pro-Taper rotary system to an apical p... | ['Dental Pulp Cavity', 'Edetic Acid', 'Humans', 'Microscopy, Electron, Scanning', 'Needles', 'Root Canal Irrigants', 'Root Canal Preparation', 'Smear Layer', 'Sodium Hypochlorite', 'Therapeutic Irrigation', 'Tooth Apex', 'Ultrasonics'] | 23,595,996 | [['A14.549.167.900.265'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E07.612'], ['D25.800', 'D27.505.954.122.425.300.500', 'D27.720.274.300.500', 'J01.637.051.800'], ['E06.397.778.889', 'E06.931.625'], ['C07.793.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Increase in prevalence of physician-diagnosed asthma in Helsinki during the Finnish Asthma Programme: improved recognition of asthma in primary care? A cross-sectional cohort study. | BACKGROUND: The continuing rise in asthma prevalence has been questioned, with recent reports suggesting a plateau.AIMS: To assess a 10-year trend in the age-adjusted prevalence of physician-diagnosed asthma, respiratory and allergic symptoms, and use of asthma medication in the adult population of Helsinki during the ... | ['Adult', 'Aged', 'Asthma', 'Cohort Studies', 'Cross-Sectional Studies', 'Female', 'Finland', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Primary Health Care', 'Young Adult'] | 23,299,455 | [['M01.060.116'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Role of endogenous histamine in altered lung mechanics in rabbits. | BACKGROUND: Unlike the effects of exogenous histamine, those of endogenous histamine on the lung mechanics have not yet been characterized. The site of endogenous histamine liberation by mivacurium was determined, as were the effects of this histamine on the airway and parenchymal mechanics in control rabbits (group C)... | ['Airway Resistance', 'Algorithms', 'Animals', 'Blood Pressure', 'Histamine', 'Histamine Antagonists', 'Isoquinolines', 'Lung', 'Male', 'Mivacurium', 'Models, Biological', 'Neuromuscular Nondepolarizing Agents', 'Pulmonary Circulation', 'Rabbits', 'Respiratory Mechanics'] | 11,818,775 | [['E01.370.386.700.050', 'G09.772.060'], ['G17.035', 'L01.224.050'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['D27.505.519.625.375.425', 'D27.505.696.577.375.425'], ['D03.633.100.531'], ['A04.411'], ['D03.633.100.531.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Crush syndrome of today - rhabdomyolysis of intoxication]. | Crush syndrome is a major issue in war-afflicted countries and in times of peace also in case of a mining accident. This syndrome is characterized by a number of symptoms originating from muscle damage - rhabdomyolysis - resulting from long-lasting entrapment of the body/extremities. Nowadays, crush syndrome seems to b... | ['Crush Syndrome', 'Humans', 'Immobilization', 'Rhabdomyolysis', 'Substance-Related Disorders'] | 24,981,700 | [['C26.257.500', 'C26.797.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.472'], ['C05.651.807'], ['C25.775', 'F03.900']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Expression of long noncoding RNA STCAT3 in gastric cancer tissues and its effect on malignant phenotype of gastric cancer cells]. | Objective: To detect the expression of long noncoding RNA(lncRNA)stomach cancer-associated transcript-3(STCAT3) in gastric cancer tissues, adjacent tissues, human gastric cancer cell lines and normal gastric epithelial cell lines, and to investigate the relationship between STCAT3 expression and clinicopathological fea... | ['Animals', 'Cell Movement', 'Cell Proliferation', 'Disease Progression', 'Mice, Nude', 'Phenotype', 'RNA, Long Noncoding', 'Real-Time Polymerase Chain Reaction', 'Stomach Neoplasms', 'Transfection', 'Up-Regulation'] | 27,998,431 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C23.550.291.656'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['G05.695'], ['D13.444.735.790.375'], ['E05.393.620.500.706'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['E05.393.350.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multiple sclerosis, idiopathic dilated cardiomyopathy, and insulin-dependent diabetes mellitus: a common mechanism of irregular immune regulation. | BACKGROUND: Multiple sclerosis (MS), idiopathic dilated cardiomyopathy (DCM), and diabetes mellitus-1 (DM-1) are polygenic autoimmune diseases with a pivotal autoimmune component affecting young adults. They share a number of characteristics, thereby suggesting common underlying pathways or mechanisms. Typically, the a... | ['Adult', 'Autoantibodies', 'Cardiomyopathy, Dilated', 'Comorbidity', 'Diabetes Mellitus, Type 1', 'Humans', 'Male', 'Multiple Sclerosis'] | 21,532,390 | [['M01.060.116'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection. | Inflammatory responses mediated by antigen-presenting dendritic cells (DCs), can be modulated by the presence of prostaglandins (PG), including prostaglandin E2 (PGE2). PGE2 modifies the production of an immune response by altering DC function through PGE2 receptors. PGE2 is produced by epithelial cells lining the muri... | ['Animals', 'Cells, Cultured', 'Chlamydia Infections', 'Chlamydia muridarum', 'Dendritic Cells', 'Dinoprostone', 'Female', 'Gene Expression Regulation', 'Genital Diseases, Female', 'Interleukin-10', 'Lymph Nodes', 'Mice', 'Mice, Inbred BALB C', 'RNA, Messenger', 'T-Lymphocyte Subsets'] | 17,680,801 | [['B01.050'], ['A11.251'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['B03.440.190.190.190.500'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.7... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration. | BACKGROUND: Clinical data have shown that an increased level of serum soluble CD40 ligand (sCD40L) is associated with atherosclerogenesis. We hypothesize that sCD40L induces proliferation and migration of vascular smooth muscle cells (VSMCs) through activation of matrix metalloproteinases (MMPs).METHODS: Human VSMCs we... | ['Atherosclerosis', 'CD40 Ligand', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'Coronary Vessels', 'Dose-Response Relationship, Drug', 'Humans', 'Hyperplasia', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Muscle, Smooth, Vascular', 'RNA, Messenger', 'Tunica Intima'] | 19,541,004 | [['C14.907.137.126.307'], ['D12.644.276.374.750.124', 'D12.776.395.550.185', 'D12.776.467.374.750.124', 'D12.776.543.550.198', 'D23.529.374.750.124'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['A07.015.114.269', 'A07.015.908.194'], ['G07.690.773.875', 'G07.690.936.500'], ['B0... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dianthins, ribosome-damaging proteins with anti-viral properties from Dianthus caryophyllus L. (carnation). | 1. Dianthin 30 and dianthin 32, two proteins isolated from the leaves of Diathus caryophyllus (carnation), were purified to homogeneity by chromatography on CM-cellulose. 2. The mol.wt. of dianthin 30 is 29 500 and that of dianthin 32 is 31 700. Both dianthins are glycoproteins containing mannose. 3. Dianthins inhibit ... | ['Antiviral Agents', 'Chromatography, Ion Exchange', 'Electrophoresis, Polyacrylamide Gel', 'Plant Proteins', 'Protein Biosynthesis', 'Ribosome Inactivating Proteins, Type 1', 'Ribosomes', 'Tobacco Mosaic Virus'] | 7,316,958 | [['D27.505.954.122.388'], ['E05.196.181.400.383'], ['E05.196.401.402', 'E05.301.300.319'], ['D12.776.765'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D08.811.277.450.430.700.500', 'D12.776.765.710.500'], ['A11.284.430.214.190.875.811'], ['B04.715.464.725.800', 'B04.820.578.844.800']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A cycle ergometer test of maximal aerobic power. | An indirect test of maximal aerobic power (IMAP) was evaluated in 31 healthy male subjects by comparing it with a direct treadmill measurement of maximal aerobic power (VO2 max), with the prediction of VO2 max from heart rate during submaximal exercise on a cycle ergometer using Astrand's nomogram, with the British Arm... | ['Adult', 'Humans', 'Male', 'Oxygen Consumption', 'Respiratory Function Tests', 'Running'] | 7,201,923 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.680'], ['E01.370.386.700'], ['G11.427.410.568.610', 'G11.427.410.698.277.750', 'I03.350.750', 'I03.450.642.845.610']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Experiences of Negotiations for Improving Research Environment and Burnout among Young Physician Researchers in Japan. | Physician scientists in Japan are often too busy to be sufficiently involved in research work. This cross-sectional study aimed to investigate their experiences negotiating with their superiors to improve their research environment and determine its relationship with psychological burnout. Among 1790 physician awardees... | ['Aged', 'Burnout, Professional', 'Burnout, Psychological', 'Cross-Sectional Studies', 'Female', 'Humans', 'Japan', 'Male', 'Negotiating', 'Physicians', 'Surveys and Questionnaires'] | 32,698,340 | [['M01.060.116.100'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['F01.145.126.990.367', 'F02.830.900.333'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['F01.145.209.520', 'F0... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Structure-activity relationship of parathyroid hormone: relative sensitivity of rabbit renal microvessel and tubule adenylate cyclases to oxidized PTH and PTH inhibitors. | It has been shown previously that secondary structural changes of bPTH-(1-34) (synthetic amino-terminal (1-34) fragment of bovine parathyroid hormone), obtained by oxidation of the methionines 8 and 18, abolished its hypotensive but not its hypercalcemic action. Hence, it has been postulated that the various physiologi... | ['Adenylyl Cyclases', 'Animals', 'In Vitro Techniques', 'Kidney Cortex', 'Kidney Tubules', 'Methionine', 'Microbial Collagenase', 'Microcirculation', 'Oxidation-Reduction', 'Parathyroid Hormone', 'Peptide Fragments', 'Rabbits', 'Renal Circulation', 'Structure-Activity Relationship', 'Teriparatide'] | 2,820,761 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['E05.481'], ['A05.810.453.324'], ['A05.810.453.736.560'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.549', 'D12.125.166.676'], ['D08.811.277.656.300.480.205.500', 'D08.811.277.656.675.374.205.500'], ['G09.330.100.645'], ['G02.700', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Local panatrophy with linear distribution: a clinical, ultrastructural and biochemical study. | A young female with local panatrophy of the right-side extremities affecting all mesodermal layers--dermis, subcutaneous tissue, muscles, and bone--is described. The atrophies were strictly linear. Ultrastructurally, collagen fibrils of the reticular dermis from the atrophic area consisted of two types, a large populat... | ['Adolescent', 'Atrophy', 'Collagen', 'Female', 'Glycosaminoglycans', 'Humans', 'Microscopy, Electron', 'Skin'] | 6,179,331 | [['M01.060.057'], ['C23.300.070'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D09.698.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['A17.815']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phase II studies of mitoxantrone in patients with primary liver cancer. | Forty-nine patients with histologically confirmed primary liver cancer have been entered on phase II trials of mitoxantrone (Novantrone; dihydroxyanthracenedione), at a dose of 14 mg/m2 every 3 weeks. Among the patients evaluable for toxicity, leukopenia and thrombocytopenia were the most important side-effects encount... | ['Adult', 'Aged', 'Anthraquinones', 'Antineoplastic Agents', 'Drug Evaluation', 'Humans', 'Leukopenia', 'Liver Neoplasms', 'Middle Aged', 'Mitoxantrone', 'Thrombocytopenia'] | 4,019,121 | [['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['D27.505.954.248'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.553.546'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['D02.455.426.559.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cooperative computer system for genome sequence analysis. | Analysis of the huge volumes of data generated by large scale sequencing projects clearly requires the construction of new sophisticated computer systems. These systems should be able to handle the biological data as well as the results of the analysis of this data. They should also help the user to choose the most app... | ['Bacillus subtilis', 'Base Sequence', 'Codon', 'Computer Systems', 'Databases, Factual', 'Escherichia coli', 'Genome', 'Genome, Bacterial', 'Models, Genetic', 'Software'] | 7,584,444 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['L01.224.230'], ['L01.313.500.750.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gas chromatographic determination of aromatic amines in water samples after solid-phase extraction and derivatization with iodine. II. Enrichment. | A procedure for the enrichment of aromatic amines via solid-phase extraction was developed. A HR-P phase based on styrene-divinylbenzene was used for the investigations, generally followed by derivatization with iodine and determination via GC-ECD. The recoveries of 53 aromatic amines in a drinking water matrix at pH 9... | ['Amines', 'Calibration', 'Chromatography, Gas', 'Electrochemistry', 'Gas Chromatography-Mass Spectrometry', 'Hydrogen-Ion Concentration', 'Indicators and Reagents', 'Iodine', 'Water Pollutants, Chemical', 'Water Supply'] | 9,691,297 | [['D02.092'], ['E05.978.155'], ['E05.196.181.349'], ['H01.181.529.307'], ['E05.196.181.349.500', 'E05.196.566.500'], ['G02.300'], ['D27.720.470.410'], ['D01.268.380.400'], ['D27.888.284.903.655'], ['J01.293.821.500']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Stochastic resonance with a mixture of sub-and supra-threshold stimuli in a population of neuron models. | This paper presents a novel type of stochastic resonance (SR) with a mixture of sub- and supra-threshold stimuli in a population of neuron models beyond regular SR and Supra-threshold SR (SSR) phenomena. We investigate through computer simulations if the novel type of SR can be observed or not, using the mutual informa... | ['Action Potentials', 'Algorithms', 'Computer Simulation', 'Humans', 'Membrane Potentials', 'Models, Neurological', 'Monte Carlo Method', 'Neurons', 'Poisson Distribution', 'Reproducibility of Results', 'Signal Processing, Computer-Assisted', 'Signal-To-Noise Ratio', 'Stochastic Processes', 'Synaptic Transmission', 'Ti... | 22,256,031 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G17.035', 'L01.224.050'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395.642'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['A08... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Device-associated infections rates in adult, pediatric, and neonatal intensive care units of hospitals in the Philippines: International Nosocomial Infection Control Consortium (INICC) findings. | BACKGROUND: This study investigated the rate of device-associated health care-associated infection (DA-HAI), microbiological profiles, bacterial resistance, length of stay (LOS), and mortality rate in 9 intensive care units (ICUs) of 3 hospital members of the International Nosocomial Infection Control Consortium (INICC... | ['Adult', 'Bacterial Infections', 'Child', 'Cross Infection', 'Developing Countries', 'Drug Resistance, Bacterial', 'Humans', 'Incidence', 'Infant', 'Intensive Care Units', 'Length of Stay', 'Philippines', 'Pneumonia, Ventilator-Associated', 'Practice Guidelines as Topic', 'Prospective Studies', 'Urinary Tract Infectio... | 21,616,564 | [['M01.060.116'], ['C01.150.252'], ['M01.060.406'], ['C01.248', 'C23.550.291.875.500'], ['I01.615.500.300'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.... | ['Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis. | BACKGROUND: The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated.PATIENTS: 96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP).RESULTS: On admission, all p... | ['APACHE', 'Aged', 'Aged, 80 and over', 'C-Reactive Protein', 'Calcitonin', 'Calcitonin Gene-Related Peptide', 'Community-Acquired Infections', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pneumonia, Bacterial', 'Pneumonia, Pneumococcal', 'Predictive Value of Tests', 'Prognosis', 'Prospective Studies', 'Protein Precurso... | 10,782,390 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['D06.472.699.150', 'D06.472.931.052', 'D12.644.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term results of the FIN-RACo trial; treatment with a combination of traditional disease-modifying anti-rheumatic drugs is an excellent option in early rheumatoid arthritis. | The Finnish Rheumatoid Arthritis Combination Therapy Trial (FIN-RACo) started in 1993, in an era of disappointing results in the treatment of rheumatoid arthritis (RA). The FIN-RACo was the first trial aiming at remission and comparing two different treatment strategies: initially triple therapy with compulsory prednis... | ['Adolescent', 'Adult', 'Aged', 'Anti-Inflammatory Agents', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Disease Progression', 'Drug Therapy, Combination', 'Finland', 'Humans', 'Hydroxychloroquine', 'Longitudinal Studies', 'Methotrexate', 'Middle Aged', 'Prednisolone', 'Randomized Controlled Trials as Topic', 'Rem... | 23,073,350 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.158'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['C23.550.291.656'], ['E02.319.310'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.810.050.180.350'], ['E05.318.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Learning to navigate: experience versus maps. | People use "route knowledge" to navigate to targets along familiar routes and "survey knowledge" to determine (by pointing, for example) a target's metric location. We show that both root in separate memories of the same environment: participants navigating through their home city relied on representations and referenc... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Knowledge', 'Learning', 'Male', 'Maps as Topic', 'Middle Aged', 'Space Perception', 'Spatial Behavior', 'User-Computer Interface', 'Young Adult'] | 23,820,180 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.468'], ['F02.463.425', 'F02.784.629.529'], ['J01.897.280.500.426', 'L01.178.820.090.426'], ['M01.060.116.630'], ['F02.463.593.778'], ['F01.145.875'], ['L01.224.900.910'], ['M01.060.116.815']] | ['Named Groups [M]', 'Organisms [B]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
7-alkylcarbonyl and 7-alkyloxycarbonyl prodrugs of theophylline. | Five members (6-10) of an homologous series of 7-alkyloxycarbonyltheophylline (7-AOC-Th) and four members (2-5) of a homologous series of 7-alkylcarbonyltheophylline (7-AC-Th) prodrugs have been synthesized by known methods and characterized. All of the members in both series were much more soluble in isopropyl myrista... | ['Animals', 'Hydrogen-Ion Concentration', 'Mice', 'Phosphodiesterase Inhibitors', 'Prodrugs', 'Skin Absorption', 'Solubility', 'Theophylline'] | 11,000,542 | [['B01.050'], ['G02.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['D27.505.519.389.735'], ['D26.675'], ['G03.015.500.750', 'G03.787.024.500.750', 'G07.690.725.015.500.750', 'G13.750.778'], ['G02.805'], ['D03.132.960.751', 'D03.633.100.759.758.824.751']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Normalizing: adolescent experiences living with type 1 diabetes. | PURPOSE: The purpose of this research study was to gain a greater understanding of adolescents' experiences living with diabetes and build a theoretical paradigm to inform interventional design.METHODS: Classical grounded theory was utilized; 15 in-depth interviews of 11 subjects were conducted with Caucasian adolescen... | ['Adaptation, Psychological', 'Adolescent', 'Diabetes Mellitus, Type 1', 'Female', 'Grounded Theory', 'Humans', 'Male', 'Psychology, Adolescent', 'Quality of Life', 'Self Care', 'Social Support', 'Surveys and Questionnaires'] | 25,824,416 | [['F01.058'], ['M01.060.057'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['H01.770.644.241.424'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.628.065'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E02.900', 'I03.050.563', 'N02.421.784.680'], ['I01.880.853.500.600'], ['E05.31... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
[Treatment of rheumatoid psoriasis with bromocriptine]. | Non-steroid anti-inflammatory drugs and/or gold salts were unsuccessful alone in providing symptom relief in three men with rheumatoid psoriasis. All three were treated with bromocriptine (5 mg/d in 2 doses) after verification of normal baseline and protirelin-stimulation prolactin levels. There was a beneficial effect... | ['Adult', 'Arthritis, Psoriatic', 'Bromocriptine', 'Hormone Antagonists', 'Humans', 'Male', 'Middle Aged', 'Quality of Life'] | 8,545,382 | [['M01.060.116'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['D06.347', 'D27.505.696.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.800', 'K01.752.40... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Regulatory framework of the new wage payment system in dentistry]. | The paper presents the analysis of regulatory frameworks for wage payment system in federal, state and municipal dental clinics. The new wage payment system provided significant freedom for employers in payments size determination by regulation of basic, stimulating and compensative salary payoffs. The study highlights... | ['Dentistry', 'Economics, Dental', 'Humans', 'Legislation, Dental', 'Russia', 'Salaries and Fringe Benefits'] | 29,072,638 | [['E06', 'H02.163'], ['N03.219.224'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.615.331'], ['Z01.252.122.500', 'Z01.542.248.775'], ['N01.824.417.700', 'N04.452.677.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Pandemic Pressures:COVID-19 Poses Serious Behavioral Health Challenges. | The mental health fallout caused by COVID-19 radiates throughout Texas. In this issue, we look at four of the biggest challenges physicians are responding to as more people say that worry and stress related to coronavirus have negatively impacted their mental health. | ['Anxiety', 'Anxiety Disorders', 'Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Depression', 'Depressive Disorder', 'Humans', 'Pandemics', 'Pneumonia, Viral', 'SARS-CoV-2', 'Social Isolation', 'Stress, Psychological', 'Substance-Related Disorders', 'Suicide', 'Texas'] | 33,126,272 | [['F01.470.132'], ['F03.080'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['F01.145.126.350'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Local and systemic effects of endotoxin mastitis on the chemiluminescence of milk and blood neutrophils in dairy cows. | The local and systemic effects of intramammary lipopolysaccharide (LPS) injection on the chemiluminescence (CL) of milk and blood polymorphonuclear leukocytes (PMN) were investigated in six healthy early lactation cows. Clinical signs of acute mastitis such as fever, increased heart rate and a decreased milk production... | ['Animals', 'Cattle', 'Cell Count', 'Female', 'Lipopolysaccharides', 'Luminescent Measurements', 'Mastitis, Bovine', 'Milk', 'Neutrophils', 'Time Factors'] | 11,361,149 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['E05.196.712.516'], ['C22.196.581'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Prognostic significance of the epithelial-to-mesenchymal transition markers e-cadherin, vimentin and twist in bladder cancer. | OBJECTIVE: The goal of this study was to utilize long-term patient follow-up to determine whether epithelial-to-mesenchymal transition (EMT)-related markers can predict bladder cancer patient survival and progression of disease.MATERIALS AND METHODS: This study included 121 patients with bladder cancer. Sixty-four of t... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Biopsy', 'Cadherins', 'Disease Progression', 'Epithelial-Mesenchymal Transition', 'Female', 'Follow-Up Studies', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Recurrence, Local', 'Predicti... | 24,856,504 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['C23.550.291.656... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
[Primary leiomyosarcoma of vascular origin in the groin causing lower extremity venous compression]. | A soft tissue tumor causing left lower extremity swelling in a 43 years old female was detected in the left inguinal region and resection was performed at the Department of Cardiovascular Surgery of Semmelweis University of Medicine, Budapest. Histologic examination revealed primary leiomyosarcoma of vascular origin. O... | ['Adult', 'Constriction, Pathologic', 'Diagnosis, Differential', 'Edema', 'Female', 'Humans', 'Leg', 'Leiomyosarcoma', 'Neoplasms, Vascular Tissue', 'Tomography, X-Ray Computed', 'Veins'] | 11,299,587 | [['M01.060.116'], ['C23.300.287'], ['E01.171'], ['C23.888.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['C04.557.450.590.455', 'C04.557.450.795.455'], ['C04.557.645'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.35... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Malignant angioendotheliomatosis. An angiotropic lymphoma? | A 61-year-old women developed progressive neurologic deficits and died with pneumonia and septicemia. An autopsy demonstrated the characteristic intravascular and focal perivascular infiltrate of malignant angioendotheliomatosis (MAE) throughout the body but concentrated in the central nervous system and skin. Ultrastr... | ['Antigens', 'Autopsy', 'Brain Neoplasms', 'Factor VIII', 'Female', 'Hemangioendothelioma', 'Histocompatibility Antigens', 'Histocytochemistry', 'Humans', 'Immunochemistry', 'Lectins', 'Leukocyte Common Antigens', 'Lymphoma', 'Middle Aged', 'Plant Lectins', 'Skin Neoplasms', 'Spinal Cord Neoplasms', 'von Willebrand Fac... | 3,155,908 | [['D23.050'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D12.776.124.125.350', 'D12.776.811.286', 'D23.119.350'], ['C04.557.645.375.370'], ['D23.050.301.500', 'D23.050.705.552'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
Development of takotsubo cardiomyopathy with severe pulmonary edema before a cesarean section. | Takotsubo cardiomyopathy is an acute syndrome involving apical ballooning and consequent dysfunction of the left ventricle. Most cases of left ventricular dysfunction resolve within 1 month. We present the case of a 40-year-old woman who developed severe heart failure caused by takotsubo cardiomyopathy with severe left... | ['Adult', 'Anesthesia, General', 'Cesarean Section', 'Echocardiography', 'Female', 'Heart Failure', 'Humans', 'Pregnancy', 'Pulmonary Edema', 'Takotsubo Cardiomyopathy', 'Ventricular Dysfunction, Left'] | 23,877,950 | [['M01.060.116'], ['E03.155.197'], ['E04.520.252.500'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C08.381.742'], ['C14.280.945.900.500'], ['C14.280.945.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The diagnostic value of the measurement of matrix metalloproteinase 9 (MMP-9), squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) in the sera of esophageal cancer patients. | BACKGROUND: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases associated with tumor progression. It was proved that expression of MMP-9 in human esophageal cancer tissues correlated with stages of the disease. The aim of the present study was to determine potential clinical use of serum MMP-9 as a tumo... | ['Aged', 'Antigens, Neoplasm', 'Biomarkers, Tumor', 'Carcinoembryonic Antigen', 'Case-Control Studies', 'Esophageal Neoplasms', 'Female', 'Humans', 'Male', 'Matrix Metalloproteinase 9', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'ROC Curve', 'Sensitivity and Specificity', 'Serpins'] | 18,155,162 | [['M01.060.116.100'], ['D23.050.285'], ['D23.101.140'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Snakebite envenoming in Kerala, South India: clinical profile and factors involved in adverse outcomes. | BACKGROUND: Snakebite envenoming is an important medical emergency in Kerala, but the factors leading to complications have not been well studied.OBJECTIVES: To study the clinical characteristics, factors involved in complications and the outcomes in relation to timing of polyvalent snake antivenom (SAV) administration... | ['Acute Kidney Injury', 'Adult', 'Antivenins', 'Blood Coagulation Disorders', 'Drug Administration Schedule', 'Emergency Service, Hospital', 'Female', 'Humans', 'India', 'Leukocyte Count', 'Male', 'Middle Aged', 'Prognosis', 'Prospective Studies', 'Severity of Illness Index', 'Snake Bites', 'Snake Venoms', 'Treatment O... | 18,356,348 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116'], ['D12.776.124.486.485.114.573.601.138', 'D12.776.124.790.651.114.573.601.138', 'D12.776.377.715.548.114.573.601.138', 'D20.215.401.601.163'], ['C15.378.100'], ['E02.319.283'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'],... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles. | Equilibrium constants for hydration of ketones, in dilute D2O solution at 34 degrees C, observed by proton magnetic resonance under conditions of slow exchange, were acetone 0.002, chloroacetone 0.08, 1,3-dichloroacetone 4.17, bromoacetone 0.07, and 1,3-dibromoacetone (an inhibitor of papain) 1.85. Neither acetamidoace... | ['Acetaldehyde', 'Acetone', 'Deuterium', 'Hydrogen Bonding', 'Isotope Labeling', 'Mercaptoethanol', 'Protease Inhibitors', 'Spectrophotometry, Ultraviolet', 'Structure-Activity Relationship'] | 911,797 | [['D02.047.064'], ['D02.522.064'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['G02.282'], ['E05.522'], ['D02.033.375.534', 'D02.886.489.409'], ['D27.505.519.389.745'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thermodynamic characterization of the multivalent binding of chartreusin to DNA. | Characterization of the thermodynamics of DNA- drug interactions is a very useful part in rational drug design. Isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC) and UV melting experiments have been used to analyze the multivalent (intercalation plus minor groove) binding of the antitumor ... | ['Animals', 'Antibiotics, Antineoplastic', 'Benzopyrans', 'Calorimetry', 'Calorimetry, Differential Scanning', 'DNA', 'Glycosides', 'Hydrophobic and Hydrophilic Interactions', 'Nucleic Acid Denaturation', 'Salmon', 'Sodium', 'Thermodynamics'] | 12,384,604 | [['B01.050'], ['D27.505.954.248.106'], ['D03.383.663.283', 'D03.633.100.150'], ['E05.196.131'], ['E05.196.131.310', 'E05.196.370.310'], ['D13.444.308'], ['D09.408'], ['G02.409'], ['E05.393.640', 'G02.111.603', 'G05.627'], ['B01.050.150.900.493.817.750.705'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mycophenolic acid for lymphomatoid papulosis. | BACKGROUND: Lymphomatoid papulosis is a rare CD30+ lymphoproliferative T-cell disorder with limited effective treatments.OBJECTIVE: We describe the case of a 50-year-old woman diagnosed with lymphomatoid papulosis who was unable to access phototherapy and who failed to clear while on systemic treatment with methotrexat... | ['Female', 'Humans', 'Immunosuppressive Agents', 'Lymphomatoid Papulosis', 'Middle Aged', 'Mycophenolic Acid', 'Skin Neoplasms'] | 24,067,853 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['C04.557.386.480.750.800.528', 'C15.604.515.569.480.750.800.528', 'C20.683.515.761.480.750.800.528'], ['M01.060.116.630'], ['D02.241.081.193.678', 'D10.251.618'], ['C04.588.805', 'C17.800.882']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression of N-methyl-d-aspartate receptor 1 in rats with chronic ocular hypertension. | High levels of glutamate can be toxic to retinal ganglion cells (RGCs). This study investigated the relationship between the N-methyl-d-aspartate receptor 1 (NR) and RGC death in a rat model of chronic ocular hypertension (COHT). COHT was induced in one eye of each rat by episcleral vein cauterization. Retinal protein ... | ['Analysis of Variance', 'Animals', 'Cell Death', 'Disease Models, Animal', 'Excitatory Amino Acid Antagonists', 'Gene Expression Regulation', 'Intraocular Pressure', 'Male', 'Memantine', 'Ocular Hypertension', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, N-Methyl-D-Aspartate', 'Retinal Ganglion Cells', 'Stilbamidines',... | 17,942,238 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G04.146'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['G05.308'], ['G14.440'], ['D02.455.426.100.050.035.500'], ['C11.525'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The acid phosphatase activity in lymphocytes with regard to the ontogenetic development of man. | In 120 healthy subjects aged from 1 day of life to 90 years the activity and intracellular localization of acid phosphatase (AP) in the peripheral blood lymphocytes has been evaluated by using semiquantitative cytochemical method (Barka and Anderson 1962). The long lasting stability of the lysosomal apparatus of lympho... | ['Acid Phosphatase', 'Adolescent', 'Adult', 'Aged', 'Aging', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Leukocyte Count', 'Lymphocytes', 'Lysosomes', 'Male', 'Middle Aged'] | 6,194,068 | [['D08.811.277.352.650.025'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.20... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of ecgonine methyl ester in the interpretation of cocaine concentrations in postmortem blood. | A study of the metabolism of in vivo cocaine (COC) and the stability of in vitro COC suggests that the presence of benzoylecgonine (BE) in unpreserved blood arises from in vivo COC metabolism and that ecgonine methyl ester (EME) in unpreserved blood arises from in vitro COC hydrolysis. Postmortem cases positive for COC... | ['Adolescent', 'Adult', 'Blood Preservation', 'Cocaine', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Male', 'Middle Aged', 'Postmortem Changes'] | 1,294,838 | [['M01.060.057'], ['M01.060.116'], ['E02.792.833.230', 'E05.760.833.230'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.260.224.617']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial cells. | Accumulation of extracellular matrix is a characteristic of diabetic nephropathy, and advanced glycation end products (AGEs) are considered to play an important role in the mechanism. To investigate the involvement of the receptor for AGE (RAGE) in upregulation of type IV collagen by AGEs, we applied the hammerhead rib... | ['Animals', 'Base Sequence', 'Cell Line', 'Cloning, Molecular', 'Collagen', 'Diabetic Nephropathies', 'Gene Expression Regulation', 'Glomerular Mesangium', 'Glycation End Products, Advanced', 'Immunohistochemistry', 'Mice', 'Molecular Sequence Data', 'RNA, Catalytic', 'RNA, Messenger', 'Receptor for Advanced Glycation ... | 9,571,198 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['E05.393.220'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['G05.308'], ['A05.810.453.324.359.620.500', 'A05.810.453.736.520.620.500'], ['D12.776.643.500'], ['E01.37... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Posttraumatic stress disorder in male and female Dutch Resistance veterans of World War II in relation to trait anxiety and depression. | In this study, 680 male and 144 female Dutch Resistance veterans of World War II were evaluated on Posttraumatic Stress Disorder, trait anxiety, and depression. Approximately 27% of these men and 20% of these women showed current Posttraumatic Stress Disorder. Resistance veterans, as a group, appeared comparable to the... | ['Aged', 'Anxiety Disorders', 'Combat Disorders', 'Cross-Cultural Comparison', 'Depressive Disorder', 'Female', 'Gender Identity', 'Humans', 'Male', 'Middle Aged', 'Netherlands', 'Personality Inventory', 'Veterans', 'Warfare'] | 8,153,220 | [['M01.060.116.100'], ['F03.080'], ['F03.950.750.249'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['F03.600.300'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.651'], ['F04.711.647.513'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye. | To identify the proteomic alterations associated with carcinogenesis of hepatocellular carcinoma (HCC), we compared the protein expression profiles of nine HCC cell lines with those of primary cultured hepatocytes established from five individuals. A differential proteomic study was performed by two-dimensional differe... | ['Adult', 'Aged', 'Amino Acid Sequence', 'Carcinoma, Hepatocellular', 'Cells, Cultured', 'Cysteine', 'Electrophoresis, Gel, Two-Dimensional', 'Female', 'Fluorescent Dyes', 'Hepatocytes', 'Humans', 'Infant', 'Liver Neoplasms', 'Male', 'Mass Spectrometry', 'Middle Aged', 'Molecular Sequence Data', 'Proteome', 'Proteomics... | 15,751,005 | [['M01.060.116'], ['M01.060.116.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['E05.196.401.250', 'E05.301.300.230'], ['D27.720.233.34... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Oxidative Stress and Environmental Exposures are Associated with Multiple System Atrophy in Chinese Patients. | OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). The aim of this study is to examine oxidant biomarkers including homocysteine (Hcys), bilirubin, uric acid, lipids, and potential environmental risk factors and to ascertain whether these data correlate with MSA in a Chinese p... | ['Aged', 'Bilirubin', 'China', 'Disability Evaluation', 'Environmental Exposure', 'Female', 'Homocysteine', 'Humans', 'Lipids', 'Male', 'Mental Status Schedule', 'Middle Aged', 'Multiple System Atrophy', 'Oxidative Stress', 'Severity of Illness Index', 'Statistics, Nonparametric', 'Uric Acid'] | 27,670,212 | [['M01.060.116.100'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['Z01.252.474.164'], ['E01.370.400'], ['N06.850.460.350'], ['D02.886.030.498', 'D12.125.166.498'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10'], ['F04.711.513.603.500', 'F04.711.513.65... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Sex steroids modulate prolactin action in spontaneously luteinizing porcine granulosa cells in vitro. | Prolactin (20-1000 ng/ml) stimulated progesterone secretion in monolayer cultures of granulosa cells isolated from mature (greater than 8 mm) porcine follicles. The action of 17 beta-estradiol alone and the interaction between estradiol and prolactin in controlling steroidogenesis were critically dependent upon the dur... | ['Androstenedione', 'Animals', 'Dihydrotestosterone', 'Estradiol', 'Estrone', 'Female', 'Granulosa Cells', 'Ovarian Follicle', 'Progesterone', 'Prolactin', 'Swine', 'Testosterone'] | 7,472,275 | [['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['B01.050'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D04.210.500.365.415.414', 'D04.210.500.578.502.497', 'D06.472.040.502.497', 'D06.472.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytomegalovirus polyradiculopathy in HIV-infected patients. | Cytomegalovirus polyradiculopathy, a late complication of HIV infection, is characterized by lower extremity weakness, urinary retention, and sacral dysesthesias. We describe four patients (mean CD4 T-cell count = 25 cells/mm3) who developed this "infectious cauda equina syndrome." The characteristic cerebrospinal flui... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Antiviral Agents', 'Cytomegalovirus Infections', 'Ganciclovir', 'Humans', 'Male', 'Peripheral Nervous System Diseases', 'Polyradiculopathy', 'Prognosis'] | 8,691,287 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['D27.505.954.122.388'], ['C01.925.256.466.245'], ['D03.633.100.759.758.399.454.250.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.668.829'], ['C10.668.829.800... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities. | The purpose of the present study was to investigate the prognostic significance of DNA ploidy, S-phase fraction and p21 ras oncoprotein expression in patients with colorectal cancer and to correlate these factors with the clinical behavior of the tumors and their response to therapy. Of 79 patients with colorectal canc... | ['Adult', 'Aneuploidy', 'Chemotherapy, Adjuvant', 'Colorectal Neoplasms', 'DNA, Neoplasm', 'Female', 'Flow Cytometry', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Neoplasm Staging', 'Oncogene Protein p21(ras)', 'Prognosis', 'Radiotherapy, Adjuvant', 'S Phase', 'Survival Rate'] | 11,471,902 | [['M01.060.116'], ['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['E02.186.170', 'E02.319.170'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D13.444.308.425'], ['E01.370.225.500.363.342', 'E01.370.225.500.3... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differences in development, glycogen, and lipid content associated with cytochrome P450-mediated permethrin resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae). | Insecticide resistance in populations of mosquitoes is an escalating problem that can directly affect disease prevalence. Determining the fitness associated with an insecticide resistance mechanism (allele) will provide for greater understanding of the evolution of resistance, and help inform effective vector managemen... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Culex', 'Cytochrome P-450 Enzyme System', 'Diet', 'Energy Metabolism', 'Female', 'Glycogen', 'Insecticide Resistance', 'Insecticides', 'Larva', 'Lipids', 'Male', 'Permethrin'] | 20,380,299 | [['G07.203.650.161'], ['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.225'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G07.203.650.240'], ['G03.295'], ['D05.750.078.562.388', 'D09.698.365.388'], ['G07.690.773.984.491'], ['D27.720.031.700.491', 'D27.888.723.491'], ['B05.500.500'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk of premature birth in multifetal pregnancy. | The risk of preterm delivery (< 37 weeks of gestation) is approximately nine times higher in women with multifetal pregnancies than in women with singleton pregnancies. However, it is possible that the risk will vary according to gestational week. To assess the risk of premature birth within 1 week by gestational age a... | ['Confidence Intervals', 'Female', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Japan', 'Obstetric Labor, Premature', 'Odds Ratio', 'Pregnancy', 'Pregnancy Outcome', 'Pregnancy, Multiple', 'Risk'] | 10,808,233 | [['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['Z01.252.474.463', 'Z01.639.595'], ['C13.703.420.491'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Collagen XXIV, a vertebrate fibrillar collagen with structural features of invertebrate collagens: selective expression in developing cornea and bone. | Tissue-specific assembly of fibers composed of the major collagen types I and II depends in part on the formation of heterotypic fibrils, using the quantitatively minor collagens V and XI. Here we report the identification of a new fibrillar-like collagen chain that is related to the fibrillar alpha1(V), alpha1(XI), an... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Animals', 'Bone and Bones', 'Cloning, Molecular', 'Collagen', 'Cornea', 'DNA, Complementary', 'Humans', 'In Situ Hybridization', 'Mice', 'Models, Genetic', 'Molecular Sequence Data', 'Oligonucleotides, Antisense', 'Peptides', 'Protein Structure, Tertiary', 'RNA', 'RNA, Mess... | 12,874,293 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A02.835.232', 'A10.165.265'], ['E05.393.220'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A09.371.060.217'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Reversible jaundice in primary biliary cirrhosis due to hyperthyroidism. | A patient with primary biliary cirrhosis had a dramatic deterioration in liver function with jaundice over 2 months as a result of development of Graves' disease. Clinical examination and radiological and cardiovascular investigations excluded heart failure and biliary obstruction as the cause of this deterioration. Th... | ['Bilirubin', 'Female', 'Humans', 'Hyperthyroidism', 'Jaundice', 'Liver', 'Liver Cirrhosis, Biliary', 'Middle Aged'] | 8,174,893 | [['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.397'], ['C23.550.429.500', 'C23.888.885.375'], ['A03.620'], ['C06.130.120.135.250.250', 'C06.552.150.250', 'C06.552.630.400', 'C23.550.355.412.400'], ['M01.06... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of bradykinin-induced synovial plasma extravasation produced by intrathecal nicotine is mediated by the hypothalamopituitary adrenal axis. | 1. Bradykinin (BK)-induced plasma extravasation (PE) in the rat knee joint, which is dependent to a large extent on the sympathetic innervation of the synovium, is powerfully inhibited, dose dependently, by intrathecal administration of nicotine, especially after interruption of the impulse traffic in afferents of the ... | ['Adrenal Glands', 'Animals', 'Bradykinin', 'Dose-Response Relationship, Drug', 'Extravasation of Diagnostic and Therapeutic Materials', 'Hypothalamo-Hypophyseal System', 'Injections, Spinal', 'Joints', 'Knee', 'Male', 'Nicotine', 'Rats', 'Rats, Sprague-Dawley', 'Synovial Fluid'] | 8,930,234 | [['A06.300.071'], ['B01.050'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'], ['G07.690.773.875', 'G07.690.936.500'], ['C23.550.340', 'C26.371'], ['A06.688.357', 'A08.186.211.180.497.352.435', 'A08.186.211.200.317.35... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of the fusionless instrumentation on the disks and facet joints of the unfused segments: a pig model. | BACKGROUND: Growing rod (GR) is a state-of-the-art procedure favored when curvatures of the spine cannot be managed nonoperatively in early-onset scoliosis. Although some postulate that multiple distractions and/or relative immobilization of the unfused segments affect the health of disk and facet joint (FJ) and cause ... | ['Animals', 'Humans', 'Intervertebral Disc', 'Models, Animal', 'Scoliosis', 'Spinal Fusion', 'Spine', 'Swine', 'Zygapophyseal Joint'] | 23,812,137 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['E05.598'], ['C05.116.900.800.875'], ['E04.555.100.700'], ['A02.835.232.834'], ['B01.050.150.900.649.313.500.880'], ['A02.835.583.979']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Computer tomography and magnetic resonance imaging in cyanide poisoning. | A 29-year-old chemistry student took 50 ml of a 1% potassium cyanide solution (500 mg) in an attempted suicide. He became comatose, mydriatic, and was admitted to hospital in an apneic state. He woke up after 7 h and developed Parkinsonism in the following weeks. This regressed slowly during the 2 months after the pois... | ['Adult', 'Basal Ganglia', 'Cyanides', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Potassium Cyanide', 'Putamen', 'Suicide, Attempted', 'Tomography, X-Ray Computed'] | 3,383,920 | [['M01.060.116'], ['A08.186.211.200.885.287.249'], ['D01.248.497.158.291', 'D01.625.400.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['D01.625.400.100.750', 'D01.745.635'], ['A08.186.211.200.885.287.249.487.550.784'], ['F01.145.126.980.875.600', 'I01.880.735.856.600'], ['E01.370.350.... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
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