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Pattern and trends of cancer in odisha, India: a retrospective study. | The burden of cancer is growing globally and is one of the top leading causes of death. Information on cancer patterns are essential for effective planning of cancer control interventions. There is limited published information available on pattern of cancer for the state of Odisha, India. The present study was an atte... | ['Female', 'Humans', 'India', 'Male', 'Neoplasms', 'Retrospective Studies'] | 23,464,454 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['C04'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Seizure detection in neonates: Improved classification through supervised adaptation. | The goal of neonatal seizure detection is the development of a patient independent system to alert staff in the neonatal intensive care unit of ongoing seizures. This study demonstrates the potential in adapting a patient independent classifier using patient specific data. Supervised adaptation is investigated using th... | ['Algorithms', 'Artificial Intelligence', 'Diagnosis, Computer-Assisted', 'Electroencephalography', 'Humans', 'Infant, Newborn', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Seizures', 'Sensitivity and Specificity'] | 19,162,803 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['L01.399.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['C10.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Effects of size at birth, childhood growth patterns and growth hormone treatment on leukocyte telomere length. | BACKGROUND: Small size at birth and rapid growth in early life are associated with increased risk of cardiovascular disease in later life. Short children born small for gestational age (SGA) are treated with growth hormone (GH), inducing catch-up in length. Leukocyte telomere length (LTL) is a marker of biological age ... | ['Adolescent', 'Adult', 'Birth Weight', 'Body Size', 'Female', 'Human Development', 'Human Growth Hormone', 'Humans', 'Leukocytes', 'Male', 'Telomere', 'Telomere Homeostasis', 'Young Adult'] | 28,178,350 | [['M01.060.057'], ['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['F01.525', 'G07.345.374'], ['D06.472.699.631.525.425.875', 'D... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. | The complete nucleotide sequence of the methylcholanthrene-inducible cytochrome P-450c gene was determined by sequence analysis of cloned genomic DNA and the sequence, consisting of 524 amino acids, of the protein was deduced therefrom. The gene for the cytochrome was approximately 6.0 kilobases long and was split into... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cytochrome P-450 Enzyme System', 'DNA', 'DNA Restriction Enzymes', 'Enzyme Induction', 'Genes', 'Methylcholanthrene', 'Nucleic Acid Hybridization', 'Phenobarbital', 'Plasmids', 'Rats'] | 6,089,174 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D13.444.308'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['G05.308.320.200'], ['G05.360.340.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synthetic studies on CP-225,917 and CP-263,114: access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-Wittig rearrangement. | An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed. | ['Heterocyclic Compounds, 4 or More Rings', 'Magnetic Resonance Spectroscopy', 'Maleic Anhydrides', 'Stereoisomerism'] | 23,289,405 | [['D03.633.400'], ['E05.196.867.519'], ['D02.113.450', 'D03.383.312.520'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats. | Schizophrenia is a complex neuropsychiatric disorder in which symptoms can be classified as either positive, such as delusions and hallucinations, or negative, such as blunted affect and social withdrawal. However, the mechanisms underlying this disease are poorly understood. There is evidence that reactive oxygen spec... | ['Anesthetics, Dissociative', 'Animals', 'Brain', 'Catalase', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Ketamine', 'Lipid Peroxidation', 'Male', 'Oxidative Stress', 'Rats', 'Rats, Wistar', 'Schizophrenia', 'Superoxide Dismutase'] | 19,454,299 | [['D27.505.696.277.100.035.075.035', 'D27.505.954.427.210.100.035.075.035'], ['B01.050'], ['A08.186.211'], ['D08.811.682.732.332'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.426.392.368.367.652'], ['G02.111.515', 'G03.295.531.587'], ['G03.673', 'G07.775.750'], ['B0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcription-translation and translation-messenger RNA decay coupling: separate mechanisms for different messengers. | Antibiotics were used to inhibit protein synthesis at specific steps in the biosynthetic pathway. In this way, it was possible to study the coupling of protein synthesis to the accumulation of biologically active mRNA in T4-infected Escherichia coli. Functional mRNA for the phage enzymes deoxynucleotide kinase (EC 2.7.... | ['Anti-Bacterial Agents', 'Chloramphenicol', 'Coliphages', 'Fusidic Acid', 'Glucosyltransferases', 'Phosphotransferases', 'Protein Biosynthesis', 'Puromycin', 'RNA, Messenger', 'RNA, Viral', 'Ribosomes', 'Rifampin', 'Tetracycline', 'Transcription, Genetic', 'Viral Proteins'] | 177,977 | [['D27.505.954.122.085'], ['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['B04.123.205'], ['D04.210.500.247.222.222.347.389', 'D04.210.500.247.808.489', 'D10.570.938.515'], ['D08.811.913.400.450.460'], ['D08.811.913.696'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D02.241.223.200.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients. | PURPOSE: Little information is available regarding the use of patient-controlled sedation (PCS) among the elderly. This study evaluated the safety and efficacy of propofol PCS among elderly patients undergoing hip or knee arthroplasty.METHODS: Forty patients, aged 65-78 yr, undergoing hip or knee arthroplasty under reg... | ['Adjuvants, Anesthesia', 'Aged', 'Anesthesia, Conduction', 'Anxiety', 'Arthroplasty', 'Cognition', 'Conscious Sedation', 'Female', 'Fentanyl', 'Hip Joint', 'Humans', 'Hypnotics and Sedatives', 'Incidence', 'Injections, Intravenous', 'Intraoperative Complications', 'Knee Joint', 'Male', 'Midazolam', 'Pain', 'Pain Measu... | 9,104,520 | [['D27.505.954.427.010'], ['M01.060.116.100'], ['E03.155.086'], ['F01.470.132'], ['E04.555.110', 'E04.680.101'], ['F02.463.188'], ['E03.250'], ['D03.383.621.265'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['E05.318.308.985.525.375', 'N01.2... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of biofluids for gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) by headspace GC-FID and GC-MS. | The past few years have seen a dramatic increase in the abuse of gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) in the United States. The abuse stems primarily from their euphoric and sedative properties, but these substances are also misused by bodybuilders as steroid alternatives. Recently there has been a... | ['4-Butyrolactone', 'Adult', 'Female', 'Forensic Medicine', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Male', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sodium Oxybate', 'Substance Abuse Detection'] | 10,999,347 | [['D02.540.150', 'D03.383.312.150'], ['M01.060.116'], ['H02.403.330', 'I01.198.780.937'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Fluorescence labeling of a single sulfhydryl group in human plasma alpha 1-proteinase inhibitor and characterization of the labeled inhibitor. | A single cysteine residue present in human plasma alpha 1-proteinase inhibitor was labeled with a fluorescent sulfhydryl reagent, N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine. The resulting fluorescent inhibitor retained nearly full inhibitory activity and formed complexes with bovine chymotrypsin, porcine pancr... | ['Blood Proteins', 'Chymotrypsin', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Pancreatic Elastase', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet', 'Sulfhydryl Reagents', 'Trypsin', 'alpha 1-Antitrypsin'] | 3,491,067 | [['D12.776.124'], ['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.760.560', 'D08.811.277.656.959.350.560'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.712.726.802', 'E05.196.867.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma. | Photodynamic therapy (PDT) is a promising cancer treatment that induces localized tumor destruction via the photochemical generation of cytotoxic singlet oxygen. PDT-mediated oxidative stress elicits direct tumor cell damage as well as microvascular injury within exposed tumors. Reduction in vascular perfusion associat... | ['Angiogenesis Inhibitors', 'Animals', 'Cell Hypoxia', 'Combined Modality Therapy', 'Cytokines', 'DNA-Binding Proteins', 'Dihematoporphyrin Ether', 'Dipeptides', 'Endothelial Growth Factors', 'Female', 'Hypoxia-Inducible Factor 1', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Lymphokines', 'Mammary Neoplasms, Experime... | 10,945,611 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['G03.197.300', 'G04.270.300'], ['E02.186'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.260'], ['D03.383.129.578.840.500.462.400.200', 'D03.633.400.909.500.462.400.200', 'D04.345.783.500.462.400.200', 'D23... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype. | UNLABELLED: Group A rotaviruses (RVs) remain a leading cause of childhood gastroenteritis worldwide. Although the G/P types of locally circulating RVs can vary from year to year and differ depending upon geographical location, those with G1P[8], G2P[4], G3P[8], G4P[8], G9P[8], and G12P[8] specificities typically domina... | ['Academic Medical Centers', 'Child, Preschool', 'Cluster Analysis', 'Evolution, Molecular', 'Gastroenteritis', 'Genome, Viral', 'Genotype', 'Humans', 'Infant', 'Infant, Newborn', 'Molecular Epidemiology', 'Molecular Sequence Data', 'Phylogeny', 'Rotavirus', 'Rotavirus Infections', 'Sequence Analysis, DNA', 'Tennessee'... | 24,429,371 | [['N02.278.020'], ['M01.060.406.448'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G05.045.250', 'G16.075.250'], ['C06.405.205'], ['G05.360.340.358.840'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.416', 'E05.393.522', 'H01.158.... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndrome. | The human immunodeficiency virus (HIV)-lipodystrophy syndrome is characterized by abnormalities of lipid metabolism, glucose homeostasis, and fat distribution. Overaccumulation of intramuscular lipid may contribute to insulin resistance in this population. We examined 63 men: HIV positive with lipodystrophy (n = 22), H... | ['Absorptiometry, Photon', 'Adipose Tissue', 'Adult', 'Blood Glucose', 'Blotting, Western', 'Body Composition', 'Enzyme-Linked Immunosorbent Assay', 'Fatty Acids, Nonesterified', 'HIV-Associated Lipodystrophy Syndrome', 'Hormones', 'Humans', 'Insulin Resistance', 'Lipid Metabolism', 'Lipids', 'Male', 'Middle Aged', 'Ps... | 12,766,180 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['A10.165.114'], ['M01.060.116'], ['D09.947.875.359.448.500'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Labor epidural placement in a woman with a cervical spinal cord stimulator. | A 37-year-old female, gravida 1 para 0, in active labor at term, with a cervical spinal cord stimulator in situ, presented for epidural analgesia for labor. She had received the cervical spinal cord stimulator some 30 months before, to treat chronic regional pain syndrome I. She was taking no medication, and was thin b... | ['Adult', 'Analgesia, Epidural', 'Analgesia, Obstetrical', 'Analgesia, Patient-Controlled', 'Arm', 'Catheters, Indwelling', 'Cervical Vertebrae', 'Chronic Disease', 'Electric Stimulation Therapy', 'Female', 'Humans', 'Pain Management', 'Pregnancy', 'Spinal Cord', 'Syndrome'] | 16,434,180 | [['M01.060.116'], ['E03.091.080'], ['E03.091.110'], ['E03.091.120'], ['A01.378.800.075'], ['E07.132.500'], ['A02.835.232.834.151'], ['C23.550.291.500'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.745', 'N04.590.607.500'], ['G08.686.784.769'], ['A08.186.854'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Study of lead accumulation in bones of Wistar rats by X-ray fluorescence analysis: aging effect. | The accumulation of lead in several bones of Wistar rats with time was determined and compared for the different types of bones. Two groups were studied: a control group (n = 20), not exposed to lead and a contaminated group (n = 30), exposed to lead from birth, first indirectly through mother's milk, and then directly... | ['Aging', 'Animals', 'Bone and Bones', 'Child', 'Diet', 'Fluorescence', 'Humans', 'Lead', 'Organometallic Compounds', 'Rats', 'Rats, Wistar', 'Spectrophotometry, Atomic', 'X-Rays'] | 22,041,936 | [['G07.345.124'], ['B01.050'], ['A02.835.232', 'A10.165.265'], ['M01.060.406'], ['G07.203.650.240'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['D02.691'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.90... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence of ischaemic heart disease risk factors in male population aged 45-54 years in Warsaw and Bratislava. Part III: Smoking and overweight. | The purpose of the study was to determine the prevalence of such ischaemic heart disease (IHD) risk factors as cigarette smoking and overweight, and the degree of IHD risk in the Polish and Slovak populations. The investigated population consisted of men aged 45-54 years; 2944 of them were from industrial plants in War... | ['Blood Pressure', 'Cholesterol', 'Coronary Disease', 'Czechoslovakia', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Poland', 'Risk', 'Smoking'] | 6,653,126 | [['E01.370.600.875.249', 'G09.330.380.076'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C14.280.647.250', 'C14.907.585.250'], ['Z01.586.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The role of Hispanic ethnicity in pediatric Wilms' tumor survival. | Wilms' tumors (WT) constitute approximately 6-14% of all childhood cancers and about 95% of all pediatric renal malignancies. While prognostic factors for this malignancy are relatively well-defined, few studies have specifically examined the role of Hispanic ethnicity in pediatric WT survival. The purpose of this stud... | ['Adolescent', 'African Continental Ancestry Group', 'Child', 'Child, Preschool', 'European Continental Ancestry Group', 'Female', 'Hispanic Americans', 'Humans', 'Infant', 'Kidney Neoplasms', 'Male', 'Proportional Hazards Models', 'Wilms Tumor'] | 23,484,868 | [['M01.060.057'], ['M01.686.508.100'], ['M01.060.406'], ['M01.060.406.448'], ['M01.686.508.400'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['E05.318.740.500.700', 'E... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of mini-dose heparin on lymphocele formation following extraperitoneal pelvic lymphadenectomy. | To evaluate the effect of mini-dose heparin therapy on lymphocele formation after extraperitoneal pelvic lymphadenectomy we reviewed the records of 38 patients undergoing this procedure for prostatic cancer during a 24-month period. All patients had a minimum of 6 months of followup. Lymphoceles occurred in 3 of 8 pati... | ['Heparin', 'Humans', 'Lymph', 'Lymph Node Excision', 'Lymphatic Diseases', 'Male', 'Pelvis', 'Postoperative Complications', 'Prostatic Neoplasms', 'Thromboembolism'] | 7,382,008 | [['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.207.270.606', 'A15.382.520.150'], ['E04.446'], ['C15.604'], ['A01.923.600'], ['C23.550.767'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['C14.907.355.590']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Student Pharmacists' Perspectives on Service-Learning Experiences in Free Clinics. | Objective. To explore student pharmacists' perspectives on the value of pharmacy-related service-learning experiences focused on caring for underserved populations. Methods. Student pharmacists were required to complete a three-hour volunteer experience at a free clinic in western Pennsylvania. Reflective essays from a... | ['Ambulatory Care Facilities', 'Education, Pharmacy', 'Empathy', 'Humans', 'Medically Underserved Area', 'Pennsylvania', 'Pharmacists', 'Problem-Based Learning', 'Social Welfare', 'Students, Pharmacy', 'Volunteers'] | 31,871,359 | [['N02.278.035'], ['I02.358.525'], ['F01.752.355', 'F01.752.543.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.650.340', 'N05.300.450.520'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['M01.526.485.780', 'N02.360.780'], ['F02.463.425.720', 'I02.158.660', 'I... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Lymphadenitis due to atypical mycobacteria. | Mycobacterium scrofulaceum is a Group II atypical mycobacterium commonly associated with lymphadenitis in children. An adult is described with a rapidly enlarging preauricular mass. Culture of biopsied material isolated M. scrofulaceum, a rare cause of disease in nonimmunocompromised adults. M. scrofulaceum is usually ... | ['Diagnosis, Differential', 'Humans', 'Lymphadenitis', 'Male', 'Middle Aged', 'Mycobacterium Infections', 'Mycobacterium Infections, Nontuberculous', 'Mycobacterium scrofulaceum'] | 2,618,916 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.604.315'], ['M01.060.116.630'], ['C01.150.252.410.040.552'], ['C01.150.252.410.040.552.475'], ['B03.510.024.962.500.720.625', 'B03.510.460.400.410.552.552.720.625']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Recombinant human growth hormone modulates the hepatic acute-phase response and P-selectin in burned rats. | The purpose of this study was to determine the effect of recombinant human growth hormone (rhGH) on serum constitutive proteins, cytokines, P-selectin, and insulin-like growth factor (IGF-1) in the thermally injured rats.Sprague-Dawley rats (64 males) were given 30% total body surface area full thickness scald burn. Th... | ['Acute-Phase Reaction', 'Animals', 'Burns', 'Human Growth Hormone', 'Insulin-Like Growth Factor I', 'Interleukin-1', 'Liver', 'Male', 'P-Selectin', 'Rats', 'Rats, Sprague-Dawley', 'Serum Albumin', 'Skin', 'Time Factors', 'Transferrin', 'Tumor Necrosis Factor-alpha', 'Weight Gain'] | 12,464,474 | [['C23.550.470.099'], ['B01.050'], ['C26.200'], ['D06.472.699.631.525.425.875', 'D12.644.548.691.525.425.875'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cardiac function, myocardial glutathione, and matrix metalloproteinase-2 levels in hypoxic newborn pigs reoxygenated by 21%, 50%, or 100% oxygen. | After asphyxia, it is standard to resuscitate the newborn with 100% oxygen, which may create a hypoxia-reoxygenation process that may contribute to subsequent myocardial dysfunction. We examined the effects of graded reoxygenation on cardiac function, myocardial glutathione levels, and matrix metalloproteinase (MMP)-2 ... | ['Animals', 'Animals, Newborn', 'Glutathione', 'Hemodynamics', 'Hypertension, Pulmonary', 'Hypoxia', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Myocardium', 'Oxidative Stress', 'Oxygen', 'Oxygen Inhalation Therapy', 'Random Allocation', 'Reperfusion', 'Swine', 'Time Factors'] | 15,803,064 | [['B01.050'], ['B01.050.050.282'], ['D12.644.456.448'], ['G09.330.380'], ['C08.381.423', 'C14.907.489.556'], ['C23.888.852.079'], ['D08.811.277.656.300.480.205.352', 'D08.811.277.656.300.480.252.420', 'D08.811.277.656.300.480.525.700.150', 'D08.811.277.656.675.374.205.352', 'D08.811.277.656.675.374.252.420', 'D08.811.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Surface fine structure of the globiferous pedicellariae of the regular echinoid, Psammechinus miliaris Gmelin. | The globiferous pedicellariae of Psammechinus miliaris are described. Two fixation methods giving minimal distortion and rapid tissue hardening were adapted for soft tissue preparation for scanning electron microscopy. The pedicellarial valves are covered by a microvillous epithelium. The outer valve epithelial microvi... | ['Animals', 'Chemoreceptor Cells', 'Cilia', 'Mechanoreceptors', 'Sea Urchins', 'Sense Organs', 'Venoms'] | 1,182,770 | [['B01.050'], ['A08.675.650.915.500', 'A08.800.950.500', 'A11.671.650.915.500'], ['A11.284.180.165'], ['A08.675.650.915.750', 'A08.800.950.750', 'A11.671.650.915.750'], ['B01.050.500.408.578'], ['A09'], ['A12.200.935', 'D20.888', 'D23.946.833']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The influence of the design on the medium to long-term hemodynamic behavior of 19 mm pericardial aortic valve prostheses. | BACKGROUND AND AIMS OF THE STUDY: The hemodynamics of five designs of 19 mm pericardial aortic valve bioprosthesis were examined by Doppler echocardiography in 48 resting patients at medium or long term follow up.METHODS: The salient differences among the five designs are that valve leaflets are mounted inside the supp... | ['Aged', 'Animals', 'Aortic Valve', 'Aortic Valve Stenosis', 'Bioprosthesis', 'Cattle', 'Echocardiography, Doppler', 'Female', 'Follow-Up Studies', 'Heart Valve Prosthesis', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prognosis', 'Prosthesis Design', 'Regression Analysis', 'Survival... | 8,953,461 | [['M01.060.116.100'], ['B01.050'], ['A07.541.510.110'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E07.695.100'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reduction of two red complex bacteria by sustained-release doxycycline and correlation to improvement in mean pocket depth. | OBJECTIVE: The objective was to evaluate the effects of an 8.5% sustained-release doxycycline-containing polymer formulation (SRDF) on deep pockets (pocket depth [PD] ? 7 mm) in chronic periodontitis. Total bacterial counts were used to estimate the number of viable bacteria present before treatment and for up to 6 mon... | ['Administration, Topical', 'Adult', 'Aged', 'Anti-Bacterial Agents', 'Bacteroidetes', 'Colony Count, Microbial', 'Delayed-Action Preparations', 'Doxycycline', 'Female', 'Humans', 'Male', 'Middle Aged', 'Periodontal Pocket', 'Periodontitis', 'Polymers', 'Porphyromonas gingivalis', 'Treatment Outcome'] | 23,738,858 | [['E02.319.267.120'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['B03.440.080'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D26.255.210', 'E02.319.300.253'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C07.46... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Spontaneous synchronization of coupled oscillator systems with frequency adaptation. | We study the synchronization of Kuramoto oscillators with all-to-all coupling in the presence of slow, noisy frequency adaptation. In this paper, we develop a model for oscillators, which adapt both their phases and frequencies. It is found that this model naturally reproduces some observed phenomena that are not quali... | ['Models, Theoretical', 'Time Factors'] | 20,481,814 | [['E05.599'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isopod (Asellus Aquaticus) size and acanthocephalan (Acanthocephalus lucii) infections. | We examined the effect of isopod size and age on the success of an acanthocephalan infection and on the effects of that infection on the growth and survival of the isopods. Groups of isopods (Asellus aquaticus) belonging to 4 size classes (juveniles, maturing adults, young adults, and older adults) were exposed to infe... | ['Acanthocephala', 'Animals', 'Female', 'Fish Diseases', 'Helminthiasis, Animal', 'Host-Parasite Interactions', 'Isopoda', 'Male', 'Perches', 'Prevalence', 'Random Allocation'] | 17,626,334 | [['B01.050.500.500.132'], ['B01.050'], ['C22.362'], ['C01.610.335.349', 'C01.610.701.377', 'C22.674.377'], ['G16.527.200.400'], ['B01.050.500.131.365.400'], ['B01.050.150.900.493.602.600'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.370.70... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spontaneous degenerative polyarthritis in male New Zealand black/KN mice. | Histopathologic studies and radiographic analysis revealed that male New Zealand black/KN (NZB/KN) mice develop degenerative polyarthritis in the joints of the forepaw and hindpaw beginning at age 2 months. Deposits of autoantibodies were observed on proliferating collagen fibers, nuclei of chondrocytes, and epidermal ... | ['Animals', 'Antibodies', 'Collagen', 'Disease Models, Animal', 'Female', 'Immunohistochemistry', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Mice, Inbred NZB', 'Osteoarthritis', 'Oxidation-Reduction', 'Radiography', 'Rheumatoid Factor', 'Species Specificity'] | 1,994,914 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Regional cerebral glucose metabolism in clinical subtypes of cerebral palsy. | Twenty-three children with 4 clinical subtypes of cerebral palsy were studied using 2-deoxy-2(18F)fluoro-D-glucose (FDG) and positron emission tomography (PET). Subtypes included spastic quadriparesis (N = 6), spastic diplegia (N = 4), infantile hemiplegia (N = 8), and choreoathetosis (N = 5). FDG-PET images were corre... | ['Adolescent', 'Athetosis', 'Brain', 'Cerebral Palsy', 'Child', 'Child, Preschool', 'Chorea', 'Female', 'Glucose', 'Hemiplegia', 'Humans', 'Infant', 'Male', 'Muscle Spasticity', 'Neuronal Plasticity', 'Paraplegia', 'Prospective Studies', 'Tomography, Emission-Computed'] | 1,797,007 | [['M01.060.057'], ['C10.597.350.110', 'C23.888.592.350.110'], ['A08.186.211'], ['C10.228.140.140.254'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.662.262.249', 'C10.597.350.250', 'C23.888.592.350.250'], ['D09.947.875.359.448'], ['C10.597.622.295', 'C23.888.592.636.312'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of whole-body vibration exercise on bone mineral content and density in thermally injured children. | BACKGROUND: Loss of bone mass, muscle mass, and strength leads to significant disability in severely burned children. We assessed the effects of exercise combined with whole-body vibration (WBV) on bone mass, lean mass (LM), and muscle strength in children recovering from burns.METHODS: Nineteen burned children (?30% t... | ['Absorptiometry, Photon', 'Adolescent', 'Body Surface Area', 'Bone Density', 'Bone Diseases, Metabolic', 'Burns', 'Child', 'Combined Modality Therapy', 'Exercise Therapy', 'Female', 'Humans', 'Male', 'Muscle Strength', 'Physical Therapy Modalities', 'Vibration'] | 26,796,240 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.057'], ['E01.370.600.115.100.231', 'E05.041.124.231', 'G07.100.100.231'], ['G11.427.100'], ['C05.116.198', 'C18.452.104'], ['C26.200'], ['M01.060.406'], ['E02.186'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli. | We have isolated temperature resistant revertants from temperature sensitive E. coli strains containing either a thermolabile glutaminyl-tRNA synthetase or leucyl-tRNA synthetase. Among the revertants which still contained the thermolabile leucyl-tRNA synthetase we found two classes of regulatory mutants (leuX and leu ... | ['Amino Acyl-tRNA Synthetases', 'Chromosome Mapping', 'Escherichia coli', 'Gene Expression Regulation', 'Genes, Regulator', 'Glutamate-Ammonia Ligase', 'Leucine-tRNA Ligase', 'Mutation', 'Operon', 'RNA, Transfer', 'RNA, Transfer, Amino Acyl', 'Temperature'] | 45,219 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TLR-mediated induction of negative regulatory ligands on dendritic cells. | Dendritic cells (DCs) shape T-cell response patterns and determine early, intermediate, and late outcomes of immune recognition events. They either facilitate immunostimulation or induce tolerance, possibly determined by initial DC activation signals, such as binding Toll-like receptor (TLR) ligands. Here, we report th... | ['CD4-Positive T-Lymphocytes', 'Dendritic Cells', 'Humans', 'Interferon-alpha', 'Ligands', 'Lipopolysaccharides', 'RNA, Double-Stranded', 'Toll-Like Receptor 3'] | 18,253,710 | [['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250'], ['D27.720.... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Establishment and characterization of two cell lines derived from human glioblastoma multiforme. | We established and characterized two cell lines derived from glioblastoma multiforme. Both cell lines exhibited tumor cell morphology and growth kinetics and showed variable expression of glial fibrillary acidic protein (GFAP), S-100, fibronectin and vimentin. Cytofluorimetrical analysis of tumor samples showed a diplo... | ['Cell Division', 'Cell Line', 'Chromosome Aberrations', 'Chromosome Banding', 'Chromosome Deletion', 'Chromosome Disorders', 'Chromosomes, Human, Pair 7', 'Culture Techniques', 'DNA, Neoplasm', 'Diploidy', 'ErbB Receptors', 'Genes, myc', 'Genes, ras', 'Glial Fibrillary Acidic Protein', 'Glioblastoma', 'Humans', 'Karyo... | 1,320,358 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['C23.550.210', 'G05.365.590.175'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.3... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Duration of action of vecuronium after an intubating dose of rapacuronium, vecuronium, or succinylcholine. | UNLABELLED: Rapacuronium (RAP) is a new, rapid-onset, short-duration, nondepolarizing neuromuscular blocker. If RAP is used to facilitate endotracheal intubation, what will the duration of a subsequent maintenance dose of vecuronium (VEC) be? We investigated the duration of action of a maintenance dose of VEC after int... | ['Adolescent', 'Adult', 'Aged', 'Anesthesia, General', 'Electromyography', 'Female', 'Humans', 'Intubation, Intratracheal', 'Male', 'Middle Aged', 'Neuromuscular Blockade', 'Neuromuscular Depolarizing Agents', 'Neuromuscular Junction', 'Neuromuscular Nondepolarizing Agents', 'Succinylcholine', 'Time Factors', 'Vecuroni... | 11,323,346 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E03.155.197'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['M01.060.116.630'], ['E03.706', 'E05.635'], ['D27.505.696.663.700.710.550'], ['A08.800.550.550.550', 'A08.850.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis. | The present study was performed to determine whether insulin resistance, independent of the prevailing hormonal milieu, occurs in the liver during sepsis. To determine this, sepsis was produced in rats by cecal ligation and puncture (CLP). Six hours later, when the rats were in the early hypermetabolic phase of sepsis,... | ['Abdomen', 'Animals', 'Dose-Response Relationship, Drug', 'Gluconeogenesis', 'Infections', 'Insulin', 'Insulin Resistance', 'Liver', 'Phenylephrine', 'Rats'] | 6,381,745 | [['A01.923.047'], ['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.158.500', 'G03.191.500'], ['C01'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['A03.620'], ['D02.033.100.291.617', 'D02.092.063.291.617'], ['B01.050.150.900.649.313.992.6... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Traumatic arteriogenic erectile dysfunction: a rat model. | We developed a rat model of traumatic arteriogenic erectile dysfunction (ED) for the study of vasculogenic ED. Bilateral ligation of the internal iliac artery was performed on 30 three-month old male Sprague-Dawley rats as an experimental group. The control group consisted of 12 rats which underwent dissection of the i... | ['Animals', 'Disease Models, Animal', 'Electric Stimulation', 'Erectile Dysfunction', 'Iliac Artery', 'Male', 'Microscopy, Electron', 'NADPH Dehydrogenase', 'Penis', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Chain Reaction', 'Staining and Labeling', 'Wounds, Penetrating'] | 11,525,315 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.723.402'], ['C12.294.644.486', 'F03.835.400'], ['A07.015.114.444'], ['E01.370.350.515.402', 'E05.595.402'], ['D08.811.682.608.550'], ['A05.360.444.492'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E05... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transforming Primary Care Practice and Education: Lessons From 6 Academic Learning Collaboratives. | Adoption of new primary care models has been slow in academic teaching practices. We describe a common framework that academic learning collaboratives are using to transform primary care practice based on our analysis of 6 collaboratives nationally. We show that the work of the collaboratives could be divided into 3 ph... | ['Academic Medical Centers', 'Attitude of Health Personnel', 'Humans', 'Internship and Residency', 'Intersectoral Collaboration', 'Interviews as Topic', 'Models, Educational', 'Physicians, Primary Care', 'Primary Health Care', 'Qualitative Research', 'United States'] | 26,334,911 | [['N02.278.020'], ['F01.100.050', 'N05.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['N04.226'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['E05.599.545', 'I02.903.302'], ['M01.526.485.810.800', 'N02.360.810.795']... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
The influence of acute stress on active and inactive renin in the rat. | The purpose of this study was to determine the influence acute stress on the plasma levels of active and inactive renin in the rat. Active and inactive plasma renins were measured in calm unanesthetized normal Wistar rats (indwelling catheter) and compared to values obtained after handling, anesthesia and decapitation.... | ['Acute Disease', 'Animals', 'Enzyme Activation', 'Male', 'Rats', 'Rats, Inbred Strains', 'Renin', 'Stress, Psychological'] | 3,533,327 | [['C23.550.291.125'], ['B01.050'], ['G02.111.263', 'G03.328'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D08.811.277.656.074.500.780', 'D08.811.277.656.300.048.780', 'D08.811.277.656.837.750'], ['F01.145.126.990', 'F02.830.900']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The cephalocaudal progression of jaundice in newborns in relation to the transfer of bilirubin from plasma to skin. | The cephalocaudal progression of jaundice was studied in 136 mature, clinically well newborns. The yellow colour of the skin was measured with the transcutaneous bilirubinometer. Significant positive correlation was found between the yellow colour of the skin in four regions and the plasma bilirubin concentration (fore... | ['Bilirubin', 'Humans', 'Infant, Newborn', 'Jaundice, Neonatal', 'Skin'] | 2,335,140 | [['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C16.614.451.500', 'C23.550.429.249.500'], ['A17.815']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil? | Nurse education has undergone many changes over the last 30 years in line with the changing expectations of the nurse's role. A review of the literature suggests that nurses are inadequately prepared for their role in medication administration. With the introduction of nurse prescribing, the issue of education in pharm... | ['Attitude', 'Curriculum', 'Education, Nursing', 'England', 'Humans', 'Pharmacology', 'Teaching'] | 12,387,758 | [['F01.100'], ['I02.158'], ['I02.358.462'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.703', 'H02.628'], ['I02.903']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study. | The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomis... | ['Adipose Tissue', 'Adiposity', 'Aged', 'Aged, 80 and over', 'Alleles', 'Body Mass Index', 'Energy Intake', 'European Continental Ancestry Group', 'Feeding Behavior', 'Female', 'Gene-Environment Interaction', 'Genetic Predisposition to Disease', 'Genetic Variation', 'Genotype', 'Humans', 'Life Style', 'Male', 'Middle A... | 26,620,191 | [['A10.165.114'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G07.203.650.240.340'], ['M01.686.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Consenting patients with femoral neck fractures--how well are we involving the patient's relatives? | The consent process is a vital part of the in-patient journey for patients admitted with a fractured neck of femur. However, an aspect that is frequently over-looked is the involvement of a patient's next of kin. We organised a pilot study in our institution to see what steps we could take to make improvements in the w... | ['Femoral Neck Fractures', 'Guidelines as Topic', 'Humans', 'Professional-Family Relations'] | 27,498,441 | [['C26.404.061.425.500', 'C26.531.750.500', 'C26.558.276.425.500'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.550']] | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans. | Cortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects. Yehuda et al. proposed a hypothesis that, in humans, the hypersensitive hypothalamus-pituitary-adrenal... | ['Biomarkers', 'Comorbidity', 'Computational Biology', 'Depression', 'Endocrine System', 'Humans', 'Hydrocortisone', 'Kinetics', 'Models, Biological', 'Models, Statistical', 'Neurosecretory Systems', 'Phenotype', 'Stress Disorders, Post-Traumatic', 'Stress, Psychological'] | 22,359,492 | [['D23.101'], ['N05.715.350.225', 'N06.850.490.687'], ['H01.158.273.180', 'L01.313.124'], ['F01.145.126.350'], ['A06'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['E05.318.740.5... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Towards the third 90: improving viral load testing with a simple quality improvement program in health facilities in Malawi. | BACKGROUND: Viral load (VL) scale-up efforts have largely focused on laboratory systems, with less attention on facility-level strengthening of staff who facilitate VL testing. To address this gap we implemented a quality improvement (QI) program at 13 health facilities in central and southern Malawi.METHODS: QI progra... | ['Adolescent', 'Adult', 'Female', 'HIV Infections', 'Health Facilities', 'Humans', 'Malawi', 'Male', 'Program Evaluation', 'Quality Improvement', 'Viral Load'] | 30,383,224 | [['M01.060.057'], ['M01.060.116'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N02.278'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.175.500'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['J01.293.754', 'N04.76... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver. | Ischemia and reperfusion cause mitochondrial dysfunctions that initiate the mitochondrial apoptosis pathway. They involve the release of cytochrome C and the activation of the caspase cascade but the mechanism(s) leading to cytochrome C release is(are) poorly understood. The aim of this study was to analyse the relatio... | ['Animals', 'Caspases', 'Cyclosporine', 'Cytochromes c', 'Drug Interactions', 'Hypoxia', 'Ischemia', 'Liver Diseases', 'Mitochondria', 'Mitochondria, Liver', 'Permeability', 'Proto-Oncogene Proteins c-bcl-2', 'Rats', 'Rats, Wistar', 'Reperfusion'] | 15,476,677 | [['B01.050'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['G07.690.773.968'], ['C23.888.852.079'], ['C23.550.513'], ['C06.552'], ['A11.284.430.214.190.875.56... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rupture of a pulmonary artery mycotic aneurysm associated with candidal endocarditis. | Candidal endocarditis can develop if candidemia occurs during Swan-Ganz catheterization. Candida endocarditis may persist for many months and is fatal unless the infected valve is resected. Herein is reported the first case of rupture of a mycotic pulmonary artery aneurysm caused by chronic candidal endocarditis. The e... | ['Amphotericin B', 'Aneurysm, Infected', 'Candidiasis', 'Catheterization, Swan-Ganz', 'Endocarditis', 'Humans', 'Male', 'Middle Aged', 'Pulmonary Artery', 'Rupture, Spontaneous', 'Time Factors'] | 3,337,118 | [['D02.540.576.500.500'], ['C01.069', 'C14.907.055.131'], ['C01.150.703.160'], ['E01.370.370.380.140.210', 'E02.148.224.165', 'E02.148.442.165', 'E04.100.814.529.937.165', 'E04.502.382.937.165', 'E05.157.250.165', 'E05.157.375.165'], ['C14.280.282'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'],... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis. | Metabolic profiles of nucleosides studied on the level of urine are closely related to the pathophysiological status of the organism. Posttranscriptional modifications of RNA (mostly tRNA) in cell nucleus are responsible for change of nucleoside levels during malignant disease. In this paper, 256 metabolite profiles fr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chemistry, Pharmaceutical', 'Electrophoresis, Capillary', 'Female', 'Humans', 'Male', 'Metabolome', 'Middle Aged', 'Nucleosides', 'Urogenital Neoplasms', 'Young Adult'] | 20,719,449 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.401.190', 'E05.301.300.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.500'], ['M01.060.116.630'], ['D09.408.595', 'D13.570'], ['C04.588.945', 'C12.758', 'C13.351.937'], ['M01.060.116.815']] | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Epipadiac duplication of the urethra]. | Urethral duplication is a less frequent malformation. The Williams classification, which is currently admit, classifies them in sagital, hypospadias or complex and collateral duplications. They can be complete, incomplete or reduced to an incomplete sinus. The most severe cases are often accompanied by multi-abnormalit... | ['Child', 'Child, Preschool', 'Congenital Abnormalities', 'Humans', 'Hypospadias', 'Male', 'Urethra', 'Urography'] | 7,725,991 | [['M01.060.406'], ['M01.060.406.448'], ['C16.131'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494.400', 'C12.706.516', 'C13.351.875.466', 'C16.131.939.516'], ['A05.360.444.492.726', 'A05.810.876'], ['E01.370.350.700.830', 'E01.370.390.830']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Galanin-induced prolactin release in rats: pharmacological evidence for the involvement of alpha-adrenergic and opioidergic mechanisms. | The mechanism by which galanin (GAL) stimulates prolactin (PRL) secretion was investigated in urethane-anesthetized male rats. The PRL release induced by intracerebroventricular (i.c.v.) injection of porcine GAL (pGAL) was similar to that induced by rat GAL. The PRL release induced by pGAL was partially blocked by alph... | ['Adrenergic alpha-Antagonists', 'Animals', 'Endorphins', 'Galanin', 'Injections, Intraventricular', 'Male', 'Naloxone', 'Peptides', 'Phentolamine', 'Prolactin', 'Rats', 'Rats, Inbred Strains', 'Receptors, Adrenergic, alpha'] | 1,692,501 | [['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['B01.050'], ['D12.644.400.575.241', 'D12.776.631.650.575.241'], ['D12.644.400.250', 'D12.776.631.650.250'], ['E02.319.267.530.550'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['D12.644'], ['D03.383.129.308.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determinants of consumer influence in a health systems agency. | An 18-month study of consumer participation and influence in a Health Systems Agency (HSA) found consumer board members to be less influential than provider board members in agency decision-making. In an effort to investigate causes of the influence deficit experienced by consumer HSA board members three issues were st... | ['Attitude of Health Personnel', 'Community Participation', 'Decision Making, Organizational', 'Governing Board', 'Health Planning', 'Health Systems Agencies', 'Humans', 'Power, Psychological', 'Social Responsibility', 'United States'] | 299,610 | [['F01.100.050', 'N05.300.100'], ['N02.421.143.212', 'N03.540.245.360'], ['N04.452.190'], ['N04.452.394'], ['N03.349', 'N03.706.615.302'], ['N03.540.452.508.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.780'], ['F01.829.500.760', 'K01.752.566.869'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Complex adjustments of photosynthetic potentials and internal diffusion conductance to current and previous light availabilities and leaf age in Mediterranean evergreen species Quercus ilex. | Mature non-senescent leaves of evergreen species become gradually shaded as new foliage develops and canopy expands, but the interactive effects of integrated light during leaf formation (Q(int)G), current light (Q(int)C) and leaf age on foliage photosynthetic competence are poorly understood. In Quercus ilex L., we me... | ['Acclimatization', 'Diffusion', 'Light', 'Mediterranean Region', 'Nitrogen', 'Photosynthesis', 'Plant Leaves', 'Quercus'] | 17,080,941 | [['G07.025.133', 'G16.012.500.133'], ['G01.202', 'G02.196'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['Z01.542.580'], ['D01.268.604', 'D01.362.625'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['A18.024.812'], ['B0... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Skin rash and bronchoalveolar histology correlates with clinical benefit in patients treated with gefitinib as a therapy for previously treated advanced or metastatic non-small cell lung cancer. | BACKGROUND: Only 15% of patients with non-small cell lung cancer (NSCLC) treated with oral epidermal growth factor tyrosine kinase inhibitor gefitinib, as a second-line therapy have objective responses. Fifty percent will have improvement of lung cancer related symptoms. It will be critical to identify patients who wil... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Brain Neoplasms', 'Bronchoalveolar Lavage Fluid', 'Carcinoma, Non-Small-Cell Lung', 'Disease Progression', 'ErbB Receptors', 'Exanthema', 'Female', 'Follow-Up Studies', 'Gefitinib', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Quinazolines', 'Retro... | 16,290,256 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E05.927.100.500'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C23.550.291.656'], ['D08.811.913.696.620.682.725.400.009', 'D1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phase II randomized trial of gallium nitrate plus fluorouracil versus methotrexate, vinblastine, doxorubicin, and cisplatin in patients with advanced transitional-cell carcinoma. | PURPOSE: A phase II randomized trial of gallium nitrate/fluorouracil (5-FU) versus dose-intense methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) was performed in poor-risk patients with advanced urothelial tract tumors. The efficacy and toxicity of these regimens were compared. Assessment of dose-intense M... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Transitional Cell', 'Cisplatin', 'Doxorubicin', 'Female', 'Fluorouracil', 'Gallium', 'Humans', 'Male', 'Methotrexate', 'Middle Aged', 'Survival Analysis', 'Treatment Outcome', 'Urologic Neoplasms', 'Vinblastine'] | 9,196,161 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.430'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D03.383.742.698.875.404'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preschoolers, but not adults, treat instrumental norms as categorical imperatives. | Hypothetical norms apply only when agents have specific goals, whereas categorical norms apply regardless of what agents want. Deciding whether a rule is hypothetical or categorical is crucial for navigating many social situations encountered by children and adults. The current research investigated whether preschooler... | ['Adolescent', 'Adult', 'Child Development', 'Child, Preschool', 'Cognition', 'Female', 'Goals', 'Humans', 'Judgment', 'Male', 'Moral Development', 'Psychology, Child', 'Social Norms', 'Young Adult'] | 28,826,577 | [['M01.060.057'], ['M01.060.116'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['F02.463.188'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['F01.752.747.616', 'F01.829.500.679', 'K01.752.566.739'], ['F04.096.628.193'], ['F01.829.750', 'I01.880.853.903'], ['M01.06... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
How adequate are one- and two-dimensional free energy landscapes for protein folding dynamics? | The molecular dynamics trajectories of protein folding or unfolding, generated with the coarse-grained united-residue force field for the B domain of staphylococcal protein A, were analyzed by principal component analysis (PCA). The folding or unfolding process was examined by using free-energy landscapes (FELs) in PC ... | ['Models, Chemical', 'Principal Component Analysis', 'Protein Folding', 'Protein Structure, Tertiary', 'Staphylococcal Protein A', 'Thermodynamics'] | 19,658,975 | [['E05.599.495'], ['E05.318.740.562'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.610'], ['D12.776.097.820', 'D23.050.161.821'], ['G01.906']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Current trends in medical ethics education in Japanese medical schools. | The Japanese medical education program has radically improved during the last 10 years. In 1999, the Task Force Committee on Innovation of Medical Education for the 21st Century proposed a tutorial education system, a core curriculum, and a medical student evaluation system for clinical clerkship. In 2001, the Model Co... | ['Clinical Clerkship', 'Curriculum', 'Education, Medical, Undergraduate', 'Ethics, Medical', 'Humans', 'Japan', 'Schools, Medical'] | 23,248,838 | [['I02.358.105'], ['I02.158'], ['I02.358.399.450'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['I02.783.495.552', 'N02.278.020.578']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Photocontrol of DNA binding specificity of a miniature engrailed homeodomain. | Control of DNA binding of HDH-3, a 18-residue polypeptide based on the recognition helix of the Q50K engrailed homeodomain, has been achieved. HDH-3 was linked to an azobenzene cross-linker through two cysteine residues in an i, i + 11 spacing. For the thermodynamically stable trans configuration of the cross-linker, t... | ['Azo Compounds', 'Circular Dichroism', 'Cross-Linking Reagents', 'DNA', 'DNA-Binding Proteins', 'Fluorescence Polarization', 'Homeodomain Proteins', 'Peptides', 'Photochemistry'] | 16,262,429 | [['D02.172'], ['E05.196.867.151'], ['D27.720.470.410.210'], ['D13.444.308'], ['D12.776.260'], ['E05.196.712.516.600.390'], ['D12.776.260.400'], ['D12.644'], ['H01.181.529.711']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo. | Doxorubicin (DOX) is an effective chemotherapy drug used to treat different types of cancers. However, DOX has severe side effects, especially life-threatening cardiotoxicity. We herein report a new approach to reduce the toxicity of DOX by embedding DOX inside human serum albumin (HSA). HSA is further fused by a molec... | ['Albumins', 'Animals', 'Antineoplastic Agents', 'Cardiotoxicity', 'Cell Line, Tumor', 'Cell Nucleus', 'Cytosol', 'Doxorubicin', 'Drug Carriers', 'Humans', 'Male', 'Mice', 'Neoplasm Transplantation', 'Neoplasms', 'Pichia', 'Serum Albumin', 'Urokinase-Type Plasminogen Activator'] | 26,346,331 | [['D12.776.034'], ['B01.050'], ['D27.505.954.248'], ['C14.280.260', 'C23.550.161', 'C25.100.389', 'C26.733.266', 'G01.750.748.500.266'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D02.455.426.559.84... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expanded CD56superbright | Natural killer (NK) cells are useful for cancer immunotherapy and have proven clinically effective against hematologic malignancies. However, immunotherapies for poor prognosis solid malignancies, including ovarian cancer, have not been as successful due to immunosuppression by solid tumors. Although rearming patients'... | ['Animals', 'Ascites', 'CD56 Antigen', 'Cell Line, Tumor', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Female', 'Humans', 'Immunotherapy, Adoptive', 'Killer Cells, Natural', 'Mice, Transgenic', 'Ovarian Neoplasms', 'Receptors, IgG', 'Xenograft Model Antitumor Assays'] | 30,018,043 | [['B01.050'], ['C23.550.081'], ['D12.776.395.550.200.250.520.156', 'D12.776.543.550.200.250.520.156', 'D23.050.301.264.894.156', 'D23.050.301.350.250.520.156', 'D23.101.100.894.156'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['G12.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Seasonality and vertical structure of microbial communities in an ocean gyre. | Vertical, seasonal and geographical patterns in ocean microbial communities have been observed in many studies, but the resolution of community dynamics has been limited by the scope of data sets, which are seldom up to the task of illuminating the highly structured and rhythmic patterns of change found in ocean ecosys... | ['Bacteria', 'Biodiversity', 'Cluster Analysis', 'DNA Fingerprinting', 'DNA, Bacterial', 'DNA, Ribosomal', 'Molecular Sequence Data', 'Oceans and Seas', 'Phylogeny', 'Polymorphism, Restriction Fragment Length', 'RNA, Ribosomal, 16S', 'Seasons', 'Seawater', 'Sequence Analysis, DNA'] | 19,494,846 | [['B03'], ['G16.500.275.157.049', 'N06.230.124.049'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.212'], ['D13.444.308.475'], ['L01.453.245.667'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Development and validation of the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale: an exploratory and methodological study. | BACKGROUND: The Massachusetts General Hospital Acupuncture Sensation Scale (MASS) is a tool to measure needle sensations. The aims of the present study were to develop a Chinese version and to assess its psychometric properties.METHODS: This study was a methodological and exploratory study. The English version of the M... | ['Acupuncture Therapy', 'Adult', 'China', 'Female', 'Hospitals, General', 'Humans', 'Male', 'Massachusetts', 'Pain Measurement', 'Pain Perception', 'Psychometrics', 'Sensation', 'Translating'] | 22,617,434 | [['E02.190.044'], ['M01.060.116'], ['Z01.252.474.164'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.550.510'], ['E01.370.600.550.324'], ['F02.463.593.504'], ['F04.711.780'], ['F02.830.816', 'G11.561.790'], ['L01.559.423.796']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Effects of surface reflectance and 3D shape on perceived rotation axis. | Surface specularity distorts the optic flow generated by a moving object in a way that provides important cues for identifying surface material properties (Doerschner, Fleming et al., 2011). Here we show that specular flow can also affect the perceived rotation axis of objects. In three experiments, we investigate how ... | ['Form Perception', 'Humans', 'Imaging, Three-Dimensional', 'Motion Perception', 'Optic Flow', 'Rotation', 'Surface Properties'] | 24,023,275 | [['F02.463.593.373', 'F02.463.593.778.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['F02.463.593.932.567'], ['F02.463.593.932.594', 'G14.700'], ['G01.482.703'], ['G02.860']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Changes in serum levels of lipid peroxidation products during labor and in the puerperium]. | OBJECTIVE: To determine the activity of reactive oxygen species (ROS) during labour by characterizing changes in maternal serum levels of lipid peroxidation end-products--MDA and lipofuscin during labour and the early post-partum period. We also tried to evaluate the relationship between levels of lipid peroxides and s... | ['Adolescent', 'Adult', 'Cesarean Section', 'Female', 'Humans', 'Labor, Obstetric', 'Lipid Peroxidation', 'Lipofuscin', 'Malondialdehyde', 'Postpartum Period', 'Pregnancy', 'Reactive Oxygen Species'] | 11,881,275 | [['M01.060.057'], ['M01.060.116'], ['E04.520.252.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769.326'], ['G02.111.515', 'G03.295.531.587'], ['D10.460', 'D23.767.550'], ['D02.047.700'], ['G08.686.702'], ['G08.686.784.769'], ['D01.339.431', 'D01.650.775']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The per-protocol effect of immediate versus deferred antiretroviral therapy initiation. | OBJECTIVE: The Strategic Timing of AntiRetroviral Treatment (START) trial found a lower risk of a composite clinical outcome in HIV-positive individuals assigned to immediate initiation of antiretroviral therapy (ART) compared with those assigned to deferred initiation. However, 30% of those assigned to deferred initia... | ['Adult', 'Anti-Retroviral Agents', 'Antiretroviral Therapy, Highly Active', 'Female', 'Follow-Up Studies', 'HIV Infections', 'Humans', 'Male', 'Time Factors', 'Treatment Outcome'] | 27,782,964 | [['M01.060.116'], ['D27.505.954.122.388.077'], ['E02.319.310.075'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Psychiatric and neurological effects of chronic solvent abuse. | This study is a review of the psychiatric and neurological effects of solvent inhalation on a group of 22 patients with chronic histories of solvent abuse, primarily toluene-based solvents. The findings suggest that the chronic inhalation of toluene-based adhesives can produce a paranoid psychosis which may persist. Ot... | ['Adolescent', 'Adult', 'Chronic Disease', 'Female', 'Humans', 'Male', 'Neurologic Examination', 'Neuropsychological Tests', 'Psychoses, Substance-Induced', 'Recurrence', 'Risk Factors', 'Solvents', 'Substance-Related Disorders', 'Toluene'] | 1,790,519 | [['M01.060.057'], ['M01.060.116'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.376.550', 'E01.370.600.550'], ['F04.711.513'], ['C25.723.809', 'C25.775.746', 'F03.700.675.600', 'F03.900.746'], ['C23.550.291.937'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. | Migraine is a chronic neurological disorder characterized by recurrent episodes of severe unilateral throbbing head pain and associated symptoms, such as photophobia. Our current understanding of the mechanisms underlying migraine has been hampered by limitations in ascertaining migraine symptoms in animal models. Clin... | ['Animals', 'Calcitonin Gene-Related Peptide', 'Light', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Migraine with Aura', 'Motor Activity', 'Photic Stimulation', 'Photophobia', 'Rats', 'Receptors, Calcitonin Gene-Related Peptide'] | 19,587,287 | [['B01.050'], ['D12.644.400.097', 'D12.776.631.650.097'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.63... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Myocardial function in hypothyroidism. Relation to disease severity and response to treatment. | Systolic time intervals (ST) were used to evaluate myocardial function prospectively in 29 hypothyroid patients. The patients were divided into three categories of disease severity: (1) severe hypothyroidism, (2) mild hypothyroidism, and (3) decreased thyroid reserve or "prehypothyroidism." Groups 1 and 2 showed decrea... | ['Female', 'Humans', 'Hypothyroidism', 'Male', 'Myocardial Contraction', 'Systole', 'Thyroid Function Tests', 'Thyroid Hormones'] | 708,167 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.482'], ['G09.330.580', 'G11.427.494.570'], ['G09.330.580.880', 'G11.427.494.570.880'], ['E01.370.374.750'], ['D06.472.931']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Inguinal hernia. Pre-peritoneal laparoscopic surgery vs. the Stoppa procedure. A prospective randomized trial: 100 cases]. | In a prospective randomized trial between totally pre peritoneal (TPP) laparoscopic surgery ant Stoppa procedure (open), 100 patients with groin hernia 'Nyhus IIIA, IIIB, IV) were included and followed during 3 years. Both groups were comparable. In the "laparoscopic" group, operating time was significatelly longer (p ... | ['Adult', 'Aged', 'Follow-Up Studies', 'Hernia, Inguinal', 'Humans', 'Intraoperative Complications', 'Laparoscopy', 'Length of Stay', 'Male', 'Middle Aged', 'Pain Measurement', 'Patient Selection', 'Prospective Studies', 'Recurrence', 'Surgical Mesh'] | 8,949,271 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.300.707.374.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structure-activity relationships for insecticidal carbamates. | Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal a... | ['Binding Sites', 'Carbamates', 'Chemical Phenomena', 'Chemistry', 'Cholinesterase Inhibitors', 'Houseflies', 'Insecticides', 'Kinetics', 'Mathematics', 'Models, Chemical', 'Structure-Activity Relationship'] | 5,315,358 | [['G02.111.570.120'], ['D02.241.081.251'], ['G02'], ['H01.181'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['B01.050.500.131.617.720.500.500.750.642.470'], ['D27.720.031.700.491', 'D27.888.723.491'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['E05.599.495'], ['G02.111.830', 'G07.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
High-throughput analysis of drug dissociation from serum proteins using affinity silica monoliths. | A noncompetitive peak decay method was used with 1 mm?4.6 mm id silica monoliths to measure the dissociation rate constants (kd) for various drugs with human serum albumin (HSA) and á1-acid glycoprotein (AGP). Flow rates up to 9 mL/min were used in these experiments, resulting in analysis times of only 20-30 s. Using a... | ['Chromatography, Affinity', 'High-Throughput Screening Assays', 'Humans', 'Kinetics', 'Orosomucoid', 'Pharmaceutical Preparations', 'Serum Albumin', 'Silicon Dioxide'] | 21,661,111 | [['E05.196.181.400.170'], ['E05.916.680'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D12.776.124.050.600', 'D12.776.124.790.106.640', 'D12.776.377.715.085.640', 'D12.776.395.560.742'], ['D26'], ['D12.776.034.841', 'D12.776.124.727'], ['D01.578.750', 'D01.650.550.825', 'D01.837.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of vector competence of UK mosquitoes for Usutu virus of African origin. | BACKGROUND: Usutu virus (USUV) is an emerging zoonotic virus originally from sub-Saharan Africa. It has been introduced into Europe on multiple occasions, causing substantial mortality within the Eurasian blackbird (Turdus merula) population. It is transmitted by the mosquito species Culex pipiens in Europe and Africa.... | ['Animals', 'Birds', 'Culex', 'Disease Vectors', 'Europe', 'Flavivirus', 'Flavivirus Infections', 'Genome, Viral', 'High-Throughput Nucleotide Sequencing', 'Mosquito Vectors', 'Saliva', 'United Kingdom'] | 29,970,149 | [['B01.050'], ['B01.050.150.900.248'], ['B01.050.500.131.617.720.500.500.750.712.500.875.225'], ['N06.850.335.188', 'N06.850.520.203.375'], ['Z01.542'], ['B04.820.578.344.350'], ['C01.925.782.350.250'], ['G05.360.340.358.840'], ['E05.393.760.319'], ['N06.850.335.188.100.500.500', 'N06.850.520.203.375.100.500.500'], ['A... | ['Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Development of nickel-doped lithium formate as potential EPR dosimeter for low dose determination. | EPR dosimetry employing L-alpha-alanine has been in vogue during the past few years, due to its tissue equivalence and linear dose response. However, L-alpha-alanine dosimetry has been improved during the past years, the sensitivity of this material is still too low for clinical applications. Polycrystalline lithium fo... | ['Electron Spin Resonance Spectroscopy', 'Formates', 'Free Radicals', 'Microwaves', 'Nickel', 'Radiation Dosage', 'Radiometry', 'Spin Labels'] | 17,129,756 | [['E05.196.867.519.274'], ['D02.241.081.420'], ['D01.339', 'D02.389'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.799'], ['D02.389.678']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. | Kennedy disease, a degenerative disorder characterized by androgen-dependent neuromuscular weakness, is caused by a CAG/glutamine tract expansion in the androgen receptor (Ar) gene. We developed a mouse model of Kennedy disease, using gene targeting to convert mouse androgen receptor (AR) to human sequence while introd... | ['Androgens', 'Animals', 'Chloride Channels', 'Disease Models, Animal', 'Female', 'Gene Expression', 'Glial Cell Line-Derived Neurotrophic Factor', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Muscle, Skeletal', 'Muscular Atrophy, Spinal', 'Mutation', 'Myogenin', 'NAV1.4 Voltage-Gated Sodium Cha... | 16,981,011 | [['D27.505.696.399.472.161'], ['B01.050'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['D12.644.276.860.381.500', 'D12.776.467.860.381.500', 'D12.776.631.600.381.500', 'D23.529.850.381.500'], ['B01.050.150.900.649.313.98... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus. | Corticosterone regulates both basal and stress-induced hypothalamic-pituitary-adrenal (HPA) axis activity in a negative-feedback fashion. However, the cellular and molecular mechanisms of this negative feedback have yet to be explicitly characterized. By comparing stress-induced c-fos and corticotropin-releasing hormon... | ['Adrenocorticotropic Hormone', 'Androstanols', 'Animals', 'Corticosterone', 'Corticotropin-Releasing Hormone', 'Dose-Response Relationship, Drug', 'Gene Expression Regulation', 'Hippocampus', 'Hypothalamo-Hypophyseal System', 'Hypothalamus', 'Male', 'Paraventricular Hypothalamic Nucleus', 'Pituitary-Adrenal System', '... | 14,622,438 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['D04.210.500.054.040'], ['B01.050'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['D06.472.699.327.740... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progression of corticospinal tract dysfunction in pre-ataxic spinocerebellar ataxia type 2: A two-years follow-up TMS study. | OBJECTIVE: Corticospinal tract (CST) dysfunction is common in the pre-ataxic stage of spinocerebellar ataxia type 2 (SCA2) but quantitative assessment of its progression over time has not been explored. The aim of this study was to quantify the progression of CST dysfunction in pre-ataxic SCA2 using transcranial magnet... | ['Adult', 'Aged', 'Disease Progression', 'Evoked Potentials, Motor', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Motor Cortex', 'Mutation', 'Pyramidal Tracts', 'Spinocerebellar Ataxias', 'Transcranial Magnetic Stimulation', 'Young Adult'] | 29,550,649 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.656'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.21... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Clinicopathological characteristics and prognosis of young esophageal cancer patients]. | OBJECTIVE: To compare the clinicopathological features and prognosis of esophageal cancer between young and elderly patients.METHODS: Clinical data of 716 patients with esophageal squamous cell carcinoma undergoing curative operation from January 1990 to December 1998 at the Cancer Center of Sun Yat-sen University were... | ['Adult', 'Age Factors', 'Carcinoma, Squamous Cell', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Prognosis', 'Proportional Hazards Models', 'Retrospective Studies'] | 24,061,996 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['C04.557.470.200.400.330', 'C04.557.470.700.400.565', 'C04.588.274.476.205.500', 'C04.588.443.353.500', 'C06.301... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Critical power may be determined from two tests in elite kayakers. | Eight highly trained male kayakers were studied in an attempt to examine whether critical power (CP), based upon four tests, could be determined from a combination of any two tests. The mean age of the subjects was 26.3 (SEM 3.8) years, mean height was 180.9 (SEM 5.1) cm, and mean body mass was 81.7 (SEM 8.3) kg. Four ... | ['Adult', 'Evaluation Studies as Topic', 'Exercise', 'Exercise Test', 'Humans', 'Male', 'Muscle Contraction', 'Sports', 'Time Factors'] | 8,162,921 | [['M01.060.116'], ['E05.337', 'N05.715.360.335'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494'], ['I03.450.642.845'], ['G01.910.857']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Thoracoscopic vagectomy for recurrent peptic ulcer disease. | Duodenal and marginal jejunal ulcers respond promptly to vagus section. When a prior gastric drainage procedure has been done, the approach of choice for these ulcers is vagectomy through the left chest. This report describes four patients who were subjected to thoracoscopic vagectomy and had prompt early benefit. A de... | ['Adult', 'Female', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Peptic Ulcer', 'Recurrence', 'Thoracoscopy', 'Vagus Nerve'] | 1,341,496 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], ['C06.405.469.275.800', 'C06.405.748.586'], ['C23.550.291.937'], ['E01.370.388.250.840', 'E04.502.250.840', 'E04.928.752'], ['A08.800.050.050.925', 'A08.800.050.600.825', 'A08.800.800.060.920', 'A08.800.800.120.900']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fullerene-PAMAM(G5) composite modified impedimetric biosensor to detect Fetuin-A in real blood samples. | The aim of this study is to develop a nanomaterial-dendrimer composite modified biosensor to detect Fetuin-A (HFA) in real blood samples. For this purpose, we designed an Electrochemical Impedance Spectroscopy (EIS) based anti-Fetuin-A (Anti-HFA) modified biosensor system and tested in real blood samples. Chronoimpedan... | ['Biosensing Techniques', 'Blood Chemical Analysis', 'Dendrimers', 'Dielectric Spectroscopy', 'Electrodes', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fullerenes', 'Humans', 'Linear Models', 'Microscopy, Electron, Scanning', 'Pregnancy', 'alpha-2-HS-Glycoprotein'] | 29,158,128 | [['E05.601.043'], ['E01.370.225.124.100', 'E05.200.124.100'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['E05.196.867.335'], ['E07.305.250'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D01.268.150.250', 'J01.637.512.600.612... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effects of catecholamine-beta-adrenoceptor-cAMP system on severe patients with heart failure. | OBJECTIVE: To investigate the association between catecholamine-beta-adrenoceptor (beta-AR)-adenosine 3', 5'-monophosphate (cAMP) system and long-term prognosis in patients with chronic heart failure (CHF).METHODS: The study population comprised 73 patients with CHF (EF: 23% +/- 10%) with a mean follow-up of 3.8 +/- 1.... | ['Adult', 'Aged', 'Catecholamines', 'Cyclic AMP', 'Death, Sudden, Cardiac', 'Female', 'Heart Failure', 'Humans', 'Lymphocytes', 'Male', 'Middle Aged', 'Receptors, Adrenergic, beta'] | 14,570,600 | [['M01.060.116'], ['M01.060.116.100'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['C14.280.383.220', 'C23.550.260.322.250'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lactase persistence, dietary intake of milk, and the risk for prostate cancer in Sweden and Finland. | Prostate carcinoma is the most common cancer in men. Its primary pathogenesis is mostly unknown. Dairy products containing lactose have been suggested to be risk factors for prostate cancer. Digestion of lactose is dependent on lactase activity in the intestinal wall. A single nucleotide polymorphism C to T residing 13... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Case-Control Studies', 'Confidence Intervals', 'Diet', 'Finland', 'Genotype', 'Humans', 'Lactase', 'Lactose', 'Logistic Models', 'Male', 'Middle Aged', 'Milk', 'Odds Ratio', 'Polymorphism, Single Nucleotide', 'Prostatic Neoplasms', 'Risk Factors', 'Su... | 17,507,622 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['G07.203.650.240'], ['Z01.542.816.186'], ['G05.380'], ['B01.050.150.900... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Diagnostic performance of diffusion-weighted imaging for differentiating benign and malignant gallbladder lesions: A systematic review and meta-analysis. | BACKGROUND: Although diffusion-weighted imaging (DWI) has been characterized as an alternative imaging modality for gallbladder (GB) lesions, it has not been routinely used in clinical practice because of relatively low signal-to-noise ratio.PURPOSE: To assess the sensitivity and specificity of the diagnostic performan... | ['Diagnosis, Differential', 'Diffusion Magnetic Resonance Imaging', 'Early Detection of Cancer', 'False Positive Reactions', 'Gallbladder', 'Gallbladder Neoplasms', 'Humans', 'Magnetic Resonance Imaging', 'ROC Curve', 'Regression Analysis', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Signal-To-Noise R... | 29,676,860 | [['E01.171'], ['E01.370.350.825.500.150'], ['E01.390.500'], ['E01.354.506'], ['A03.159.439'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.68... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PREDICTORS OF SELF-REPORTED GAINS IN A RELATIONSHIP-BASED HOME-VISITING PROJECT FOR MOTHERS AFTER CHILDBIRTH. | We assessed mothers' self-reported gains from a postpartum home-visiting (HV) project in which home visitors are volunteer mothers from the community. Hypotheses were that gains are positively related to (a) mothers' felt-closeness with their home visitor, (b) mothers' level of sociodemographic risk, and (c) the home v... | ['Adult', 'Emotions', 'Female', 'House Calls', 'Humans', 'Infant', 'Infant Care', 'Infant, Newborn', 'Middle Aged', 'Mothers', 'Parturition', 'Postnatal Care', 'Professionalism', 'Regression Analysis', 'Risk Factors', 'Self Report', 'Social Support', 'Young Adult'] | 29,461,637 | [['M01.060.116'], ['F01.470'], ['N04.452.758.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N02.421.088.120'], ['M01.060.703.520'], ['M01.060.116.630'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['G08.686.784.769.490'], ['E02.760.703.500', 'N02.421.143.620.55... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Angina preceding myocardial infarction and residual coronary narrowing after intracoronary thrombolysis. | Thirty-six consecutive patients with evolving acute myocardial infarction underwent emergent coronary angiography and intracoronary thrombolysis with urokinase. Nineteen of the patients had had angina before the infarction (group A), whereas the infarction was unheralded in the remaining 17 (group B). Thirty-two vessel... | ['Adult', 'Aged', 'Angina Pectoris', 'Angina, Unstable', 'Angioplasty, Balloon', 'Cardiac Catheterization', 'Coronary Angiography', 'Coronary Vasospasm', 'Coronary Vessels', 'Ergonovine', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prognosis', 'Retrospective Studies', 'Urok... | 2,522,718 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['E01.370.370.380.140', 'E02.148.442', 'E05.1... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Drug abuse in Poland. | The abuse of drugs in Poland, a lesser problem than that of alcoholism, has only recently become a subject of interest. Although at present it is not of crucial importance in the pathology of social life, it may still have serious effects on the individual and society. This paper discusses the results of several survey... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Education', 'Family Characteristics', 'Female', 'Humans', 'Legislation, Drug', 'Male', 'Middle Aged', 'Poland', 'Sex Factors', 'Socioeconomic Factors', 'Substance-Related Disorders'] | 248,287 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['I02'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.605', 'N03.706.615.402'], ['M01.060.116.... | ['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. | Small peptide-based agents have attracted wide interest as cancer-targeting agents for diagnostic imaging and targeted therapy. There is a need to develop new high-affinity and high-specificity peptidomimetic or small-molecule ligands against cancer cell surface receptors. Here we report on the identification of a high... | ['Animals', 'Biotin', 'Cell Line, Tumor', 'Combinatorial Chemistry Techniques', 'Databases, Factual', 'Dipeptides', 'Drug Design', 'Humans', 'Integrin alpha4beta1', 'Ligands', 'Mice', 'Mice, Nude', 'Molecular Mimicry', 'Molecular Structure', 'Mutation', 'Neoplasm Transplantation', 'Neoplasms', 'Peptides', 'Phenylurea C... | 16,767,086 | [['B01.050'], ['D03.383.129.308.080', 'D08.211.096'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.197.312', 'J01.897.836.249.249'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['D12.644.456.345'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. | Genetic defects in matriptase are linked to two congenital ichthyoses: autosomal recessive ichthyosis with hypotrichosis (ARIH, OMIM 610765) and ichthyosis, follicular atrophoderma, hypotrichosis, and hypohidrosis (IFAH, OMIM 602400). Mouse models with matriptase deficiency indicate an involvement of matriptase in supr... | ['Animals', 'Cell Differentiation', 'Cell Line, Transformed', 'Cell Proliferation', 'Epidermal Cells', 'Heterografts', 'Humans', 'Hypotrichosis', 'Ichthyosis', 'Keratinocytes', 'Mice', 'Mice, Knockout', 'Organ Culture Techniques', 'Primary Cell Culture', 'Serine Endopeptidases'] | 23,900,022 | [['B01.050'], ['G04.152'], ['A11.251.210.172'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.409'], ['A01.941.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.329.937'], ['C16.131.831.512', 'C16.614.492', 'C17.800.428.333', 'C17.800.804.512'], ['A11.409.500', 'A11.436.397'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of coral reef benthic primary producers on dissolved organic carbon and microbial activity. | Benthic primary producers in marine ecosystems may significantly alter biogeochemical cycling and microbial processes in their surrounding environment. To examine these interactions, we studied dissolved organic matter release by dominant benthic taxa and subsequent microbial remineralization in the lagoonal reefs of M... | ['Animals', 'Anthozoa', 'Bacteria', 'Carbon', 'Chlorophyta', 'Coral Reefs', 'Ecosystem', 'Light', 'Phaeophyta', 'Plankton', 'Polynesia', 'Population Dynamics', 'Rhodophyta', 'Seawater', 'Temperature', 'Water Microbiology'] | 22,125,645 | [['B01.050'], ['B01.050.500.308.237'], ['B03'], ['D01.268.150'], ['B01.650.940.150'], ['G16.500.275.157.130', 'N06.230.124.130'], ['G16.500.275.157', 'N06.230.124'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.750.600'], ['B05.080.500'], ['Z01.639.760.815'], ['I01.240.600', 'N01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
iTRAQ protein profile differential analysis between somatic globular and cotyledonary embryos reveals stress, hormone, and respiration involved in increasing plantlet regeneration of Gossypium hirsutum L. | Somatic embryo development (SED) in upland cotton shows low frequencies of embryo maturation and plantlet regeneration. Progress in increasing the regeneration rate has been limited. Here a global analysis of proteome dynamics between globular and cotyledonary embryos was performed using isobaric tags for relative and ... | ['Cotyledon', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Gossypium', 'Plant Proteins', 'Proteomics', 'Real-Time Polymerase Chain Reaction', 'Regeneration', 'Seeds'] | 25,367,710 | [['A18.024.500.750.333', 'A18.024.875.500'], ['G05.308.310'], ['G05.308.375'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['D12.776.765'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['E05.393.620.500.706'], ['G16.762'], ['A18.024.500.750', 'G07.203.300.775', 'J02... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Should all patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergo epicardial catheter ablation? | BACKGROUND: Epicardial radiofrequency catheter ablation is currently considered as the therapeutic option of choice in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and recurrent ventricular tachycardia (VT). We hypothesised that inducibility of VT may guide the ablation strategy and ... | ['Arrhythmogenic Right Ventricular Dysplasia', 'Catheter Ablation', 'Comorbidity', 'Germany', 'Heart Conduction System', 'Humans', 'Male', 'Middle Aged', 'Patient Selection', 'Pericardium', 'Prevalence', 'Retrospective Studies', 'Risk Factors', 'Tachycardia, Ventricular', 'Treatment Outcome'] | 27,900,527 | [['C14.240.400.145', 'C14.280.238.028', 'C14.280.400.145', 'C16.131.240.400.145'], ['E02.808.750.500', 'E04.014.760.500'], ['N05.715.350.225', 'N06.850.490.687'], ['Z01.542.315'], ['A07.541.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.581.500.653', 'N04.590.731'], ['A07.541.795', '... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Use of green fluorescent protein to assess urease gene expression by uropathogenic Proteus mirabilis during experimental ascending urinary tract infection. | Proteus mirabilis, a cause of complicated urinary tract infection, expresses urease when exposed to urea. While it is recognized that the positive transcriptional activator UreR induces gene expression, the levels of expression of the enzyme during experimental infection are not known. To investigate in vivo expression... | ['Animals', 'Artificial Gene Fusion', 'Bacterial Proteins', 'Blotting, Western', 'Cloning, Molecular', 'Escherichia coli', 'Female', 'Gene Expression', 'Genes, Reporter', 'Green Fluorescent Proteins', 'Kidney', 'Luminescent Proteins', 'Mice', 'Mice, Inbred CBA', 'Microscopy, Fluorescence', 'Plasmids', 'Polymerase Chain... | 9,423,875 | [['B01.050'], ['E05.393.220.250'], ['D12.776.097'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.393.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.297'], ['G05.360.340.024.340.435'], ['D12.776.532.265'], ['A05.810.453'], ['D12.776.532'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Electron microscopic studies on phagocytosis of iron particles by smooth muscle cells in experimental vascular injury induced by intravascular application of direct current (author's transl)]. | In experimentally induced arterial thrombosis of minipigs caused by intravascular application of direct current iron deposits deriving from the steel wire electrode are found. Intimal proliferation can be observed 6 weeks after induction of thrombosis. Iron deposits are phagocytized by modified smooth muscle cells part... | ['Animals', 'Female', 'Iron', 'Macrophages', 'Male', 'Microscopy, Electron', 'Muscle, Smooth', 'Phagocytosis', 'Swine', 'Thrombosis'] | 735,493 | [['B01.050'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['E01.370.350.515.402', 'E05.595.402'], ['A02.633.570', 'A10.690.467'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.688'], ['B01.050.150.900.649.313.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modernizing Evolutionary Anthropology : Introduction to the Special Issue. | Evolutionary anthropology has traditionally focused on the study of small-scale, largely self-sufficient societies. The increasing rarity of these societies underscores the importance of such research yet also suggests the need to understand the processes by which such societies are being lost-what we call "modernizati... | ['Anthropology', 'Biological Evolution', 'Humans', 'Social Change'] | 27,614,655 | [['F04.096.879.201', 'I01.076'], ['G05.045', 'G16.075'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.076.201.450.776', 'I01.880.853.400', 'N01.824.737']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Reliability of predictors of study success in medicine. | AIM: Examination of the reliability of predictors for study success found in a prospective study in the year 2002/03. We report the results of a retest in an unselected students' sample taken from the following academic year 2003/04.METHODS: In a comparison of successful and unsuccessful students in their first year at... | ['Adult', 'Austria', 'Data Interpretation, Statistical', 'Education, Medical', 'Educational Measurement', 'Educational Status', 'Female', 'Humans', 'Language', 'Male', 'Prospective Studies', 'School Admission Criteria', 'Sex Distribution', 'Surveys and Questionnaires'] | 16,937,045 | [['M01.060.116'], ['Z01.542.088'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['I02.358.399'], ['I02.399'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['E05.318.372.500.750.625', 'N05.715.360.330.500... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Catecholamines are produced by ascidian immune cells: The involvement of PKA and PKC in the adrenergic signaling pathway. | The stress response is a complex mechanism, which includes changes in the immune system to enable organisms to maintain homeostasis. The neurohormones dopamine, noradrenaline (NA) and adrenalin are responsible for the physiological modulations that occur during acute stress. In the present study, we analyzed the effect... | ['Animals', 'Catecholamines', 'Cyclic AMP-Dependent Protein Kinases', 'Hemocytes', 'Nitric Oxide', 'Protein Kinase C', 'Signal Transduction', 'Urochordata'] | 28,089,640 | [['B01.050'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['A11.118.480', 'A15.145.229.480'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D08.811.913.696.620.682.700.725'], ['G02.111.820', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Jaw reflex in Friedreich ataxia. | Twenty-one patients with Friedreich ataxia were examined and found to have a brisk jaw reflex. This previously unreported clinical finding contrasts with the impairment of tendon reflexes in the limbs and should not rule out the diagnosis of Friedreich ataxia. | ['Adolescent', 'Adult', 'Female', 'Friedreich Ataxia', 'Humans', 'Jaw', 'Male', 'Middle Aged', 'Reflex', 'Reflex, Stretch'] | 572,934 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Therapeutic effect of corneal cross-linking on symptomatic bullous keratopathy]. | PURPOSE: To evaluate the corneal cross-linking (CXL) effect on symptomatic bullous keratopathy, and its impact on the visual acuity, corneal thickness and pain symptomatology.METHODS: Twelve patients with symptomatic bullous keratophaty were included. A clinical examination with a specific questionnaire (pain scale-vis... | ['Aged', 'Aged, 80 and over', 'Corneal Diseases', 'Corneal Topography', 'Cross-Linking Reagents', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Pain Measurement', 'Photosensitizing Agents', 'Riboflavin', 'Treatment Outcome', 'Ultraviolet Rays', 'Visual Acuity'] | 19,820,784 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.204'], ['E01.370.380.150'], ['D27.720.470.410.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.550.324'], ['D27.505.954.444.600', 'D27... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enzyme-linked lectin assay (ELLA). II. Detection of carbohydrate groups on the surface of unfixed cells. | An enzyme-linked lectin assay (ELLA) has been developed to detect specific carbohydrate units on the surface of unfixed cells. The assay may be read in standard ELISA plate readers, since the cell-bound enzyme-lectin conjugate is specifically eluted from the cells prior to development of the conjugate. ELLA, when read ... | ['Alkaline Phosphatase', 'Animals', 'Cell Line', 'Cells, Cultured', 'Erythrocyte Membrane', 'Glycoproteins', 'Humans', 'Lectins', 'Membrane Proteins', 'Mice'] | 6,698,125 | [['D08.811.277.352.650.035'], ['B01.050'], ['A11.251.210'], ['A11.251'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.503'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The shape of things to come: exploring goal-directed prospection. | Through the ability to preview the future (i.e., prospection), people can anticipate how best to think, feel and act in just about any setting. But exactly what factors determine the contents of prospection? Extending research on action identification and temporal construal, here we explored how action goals and tempor... | ['Female', 'Forecasting', 'Goals', 'Humans', 'Imagination', 'Male', 'Time Factors'] | 23,499,995 | [['I01.320'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['G01.910.857']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Gene expression and localization of amelogenin in the rat incisor. | Gene expression and localization of amelogenin were studied in the developing rat incisor by the methods of in situ hybridization and immunohistochemistry. ISH revealed the first expression of amelogenin mRNA in the inner enamel epithelium of the cervical loop. The signals were clearly observed in pre-ameloblasts in th... | ['Ameloblasts', 'Amelogenesis', 'Amelogenin', 'Animals', 'Cattle', 'Dental Enamel Proteins', 'Dentin', 'Gene Expression', 'Immunohistochemistry', 'In Situ Hybridization', 'Incisor', 'Odontoblasts', 'Odontogenesis', 'RNA, Messenger', 'Rats', 'Rats, Wistar'] | 9,206,338 | [['A11.436.107'], ['G07.345.500.325.377.750.190'], ['D12.776.231.500'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D12.776.231'], ['A14.549.167.900.280'], ['G05.297'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.51... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
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