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LICENSE

@@ -0,0 +1,15 @@
+Creative Commons Attribution 4.0 International (CC BY 4.0)
+
+Copyright (c) 2026 DBbun LLC
+
+This dataset is licensed under the Creative Commons Attribution 4.0
+International License. You are free to share (copy and redistribute the
+material in any medium or format) and adapt (remix, transform, and build
+upon the material for any purpose, even commercially), under the
+following terms: you must give appropriate credit, provide a link to the
+license, and indicate if changes were made.
+
+Full license text: https://creativecommons.org/licenses/by/4.0/legalcode
+
+When citing this dataset, please credit DBbun LLC and link to the
+dataset's persistent Hugging Face URL.

README.md

@@ -46,20 +46,61 @@ all values are computationally generated, with row-level provenance
 metadata distinguishing literature-grounded generated values from
 inferred and reported values.
 
+## Repository structure
+
+```
+/
+├── README.md                            ← This file
+├── LICENSE                              ← CC-BY-4.0 license text
+│
+├── oligos.csv                           ┐
+├── chemical_modifications.csv           │
+├── oligo_modification_positions.csv     │ 8 core modeling tables
+├── biophysical_properties.csv           │ Use these directly for predictive
+├── dose_exposure.csv                    │ modeling tasks
+├── assays.csv                           │
+├── toxicity_readouts.csv                │
+├── controls.csv                         ┘
+│
+├── schema.json                          ┐
+├── data_dictionary.csv                  │
+├── data_dictionary_full.csv             │
+├── dataset_manifest.json                │ Top-level documentation
+├── reproducibility_manifest.json        │ and validation
+├── validation_summary.csv               │
+├── toxicity_readouts_calibration_audit.json  ┘
+│
+├── metadata/                            (11 governance/provenance tables:
+│                                         assumptions, provenance, sources,
+│                                         triage log, gap map, etc.)
+│
+├── evidence/                            (105 per-source and broad-context
+│                                         evidence tables documenting
+│                                         literature-grounded generation
+│                                         logic for each source paper)
+│
+└── figures/                             (5 reference figures)
+```
+
 ## How to use
 
 ```python
 import pandas as pd
 
-# Core modeling tables
+# Core modeling tables (root level)
 oligos = pd.read_csv("oligos.csv")
 mods = pd.read_csv("chemical_modifications.csv")
+positions = pd.read_csv("oligo_modification_positions.csv")
 biophys = pd.read_csv("biophysical_properties.csv")
 dose = pd.read_csv("dose_exposure.csv")
 assays = pd.read_csv("assays.csv")
 readouts = pd.read_csv("toxicity_readouts.csv")
 controls = pd.read_csv("controls.csv")
 
+# Governance / provenance metadata (in metadata/ subfolder)
+sources = pd.read_csv("metadata/sources.csv")
+provenance = pd.read_csv("metadata/provenance.csv")
+
 # Join into a model-ready table
 model_ready = (readouts
     .merge(assays, on="assay_id")
@@ -74,6 +115,7 @@ overall accuracy of approximately 0.84 on the calibrated dataset, with
 per-class F1 scores of 0.95 (low-risk), 0.74 (moderate), and 0.49
 (high-risk).
 
+
 ## Dataset structure
 
 ### Core modeling tables

controls.csv

@@ -0,0 +1,162 @@
+control_id,control_type,control_role,expected_behavior,control_rationale,source_basis,provenance_label,record_origin,license_for_generated_output,expected_direction,rationale,source_id,description,expected_response,expected_outcome
+CTRL_NEG_VEHICLE_MOCK,negative_control_vehicle_mock,baseline_no_active_oligo,no oligo-driven hepatotoxicity signal,Represents mock/vehicle exposure with dose set to zero.,OligoTox alignment memo control logic,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_LOW_RISK_OLIGO,negative_control_low_risk_oligo,low_sequence_chemistry_exposure_risk,"high viability, low ALT/AST proxy, low stress scores","Low PS content, low off-target burden, moderate GC content, low dose.",OligoTox predictor framework,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSIRAN,clinical_low_hepatotoxicity_reference,GalNAc_siRNA_clinical_safety_reference,low-to-moderate synthetic hepatotoxicity risk and stable liver injury readouts,Inspired by a Phase I GalNAc-siRNA trial reporting no evidence of drug-induced liver injury.,RAPIROSIRAN_SANYAL_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_HUMAN_LIVER_SPHEROID_TOLERATED,human_in_vitro_tolerated_reference,human_liver_spheroid_low_toxicity_context,sustained viability and low stress despite GalNAc-siRNA exposure,Inspired by long-term human liver spheroid GalNAc-siRNA screening with no observed hepatotoxicity under conditions used.,LIVER_SPHEROID_SCHOLTEN_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_HIGH_PS_HIGH_DOSE,positive_control_high_PS_high_dose,chemistry_exposure_high_risk,reduced viability and elevated stress/liver injury proxy,High phosphorothioate content and high dose represent a stress-test positive control.,OligoTox alignment memo predictor families,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_HIGH_OFFTARGET,positive_control_high_offtarget,sequence_offtarget_high_risk,transcriptomic perturbation and stress response signal,High predicted off-target burden and long complementarity segments stress-test sequence-dependent toxicity.,OligoTox alignment memo sequence predictor families,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_TRANSCRIPTOMIC_STRESS,positive_control_transcriptomic_stress,pathway_stress_high_risk,"elevated transcriptomic perturbation, apoptosis, and stress response scores",Designed to represent oligo-induced pathway stress for model benchmarking.,OligoTox alignment memo readout logic,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_LNA_GAPMER_HIGH_RISK,positive_control_LNA_gapmer_high_risk,gapmer_chemistry_high_risk,higher synthetic risk due to gapmer/LNA/high-PS configuration,Represents sequence/chemistry-dependent gapmer risk used as a positive control pattern.,OligoTox Phase 1 ideation logic and alignment memo,literature_grounded_generated,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_TARGETED_LNP_ASGPR_SAFE_WINDOW,negative_control_targeted_LNP_safe_window,delivery_low_risk_reference,high hepatic targeting score with low delivery-related stress,"Represents a small, neutral/slightly negative, PEGylated or ligand-targeted lipid nanocarrier within a liver-targeting size window.",MOHAMED_NANOPARTICLE_HEPATITIS_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_DELIVERY_RELATED_NP_STRESS,positive_control_delivery_related_nanocarrier_stress,delivery_high_risk_reference,"elevated delivery-related stress, immunogenicity, Kupffer clearance, and oxidative stress markers",Represents a high-risk delivery context such as cationic or inorganic nanoparticle exposure with larger particle size or oxidative-stress potential.,MOHAMED_NANOPARTICLE_HEPATITIS_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_BALANCED_HYBRID_RNA_LNP,negative_control_balanced_hybrid_RNA_LNP,balanced_payload_delivery_reference,balanced RNA co-delivery with strong payload function but without a direct hepatotoxicity-positive label,"Represents a fluorinated LNP-style dual RNA payload with siRNA:mRNA around 3:7 and high encapsulation efficiency, used as delivery/payload context rather than direct toxicity evidence.",MENG_HYBRID_RNA_LNP_HCC_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_IMMUNE_ACTIVATING_RNA_LNP_STRESS,positive_control_immune_activating_RNA_LNP_stress,immune_activation_stress_reference,"elevated immune-activation and inflammatory-stress context, with careful separation from direct oligo hepatotoxicity",Represents a strong RNA-LNP immune-activation context for stress-testing inflammatory readout generation.,MENG_HYBRID_RNA_LNP_HCC_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_APOB_ASO_LOW_LIPID_STRESS,negative_control_APOB_ASO_low_lipid_stress,lipid_homeostasis_low_stress_reference,modest APOB inhibition context with low lipid-export stress and preserved viability proxy,"Represents a low-dose Mipomersen-like APOB ASO context used as supporting lipid-homeostasis control, not as a direct hepatotoxicity claim.",CHEN_OVARIAN_MTTP_APOB_MIPOMERSEN_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_APOB_ASO_LIPID_EXPORT_STRESS,positive_control_APOB_ASO_lipid_export_stress,lipid_export_stress_reference,"high APOB inhibition, suppressed VLDL-apoB secretion proxy, and increased lipid-stress context",Represents high APOB-ASO inhibition under lipid/heat-stress style context for stress-testing lipid-homeostasis fields.,CHEN_OVARIAN_MTTP_APOB_MIPOMERSEN_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_SULT1B1_SIRNA_LIPID_RESCUE,negative_control_SULT1B1_siRNA_lipid_rescue,MASLD_epigenetic_lipid_rescue_reference,"lower SULT1B1 activity proxy, reduced lipid-accumulation context, and low-to-moderate hepatotoxicity score","Represents siRNA-mediated SULT1B1 knockdown in hepatocyte lipid-accumulation context as a rescue/low-risk benchmark, separated from direct oligo-toxicity claims.",LU_SULT1B1_SE_MASLD_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_MASLD_EPIGENETIC_LIPID_ACCUMULATION,positive_control_MASLD_epigenetic_lipid_accumulation,H3K27ac_CEBPB_SULT1B1_lipid_stress_reference,"high H3K27ac/CEBPB/SULT1B1 proxies, increased lipid accumulation, and elevated liver-stress context",Represents oleate/high-H3K27ac MASLD-like hepatocyte lipid accumulation for stress-testing liver-disease context fields.,LU_SULT1B1_SE_MASLD_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,negative_control_ANGPTL3_siRNA_liver_safety,ARO_ANG3_like_liver_safety_reference,moderate-to-high ANGPTL3 inhibition with low transaminase signal and hepatic-fat reduction context,Represents an ARO-ANG3-like GalNAc-siRNA liver-safety context with no major liver signal and possible hepatic fat reduction.,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_ANGPTL3_ASO_HEPATIC_FAT_ALT_SIGNAL,positive_control_ANGPTL3_ASO_hepatic_fat_ALT_signal,vupanorsen_like_liver_safety_signal_reference,very high ANGPTL3 inhibition with increased hepatic-fat and ALT/AST signal context,Represents a vupanorsen-like high-dose GalNAc-ASO context where high target inhibition was associated with transaminase and hepatic-fat signals.,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,positive_control_PNPLA3_I148M_homozygous_lipid_stress,PNPLA3_genetic_liver_stress_reference,GG/I148M homozygous genotype with amplified lipid-droplet accumulation and MASLD-like liver-stress context,"Represents the high-risk PNPLA3 I148M homozygous context described in human genetics literature, especially under adiposity/metabolic stress.",PNPLA3_ROMEO_VALENTI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,negative_control_PNPLA3_siRNA_homozygote_rescue,PNPLA3_precision_therapy_rescue_reference,PNPLA3 I148M homozygous context with siRNA-like knockdown and reduced hepatic-fat/inflammation proxies,Represents genotype-targeted PNPLA3 silencing as a precision-therapy rescue benchmark for homozygous carriers.,PNPLA3_ROMEO_VALENTI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_PNPLA3_HETEROZYGOUS_UNCERTAIN_RESPONSE,context_control_PNPLA3_heterozygous_uncertain_response,PNPLA3_heterozygote_response_uncertainty_reference,heterozygous PNPLA3 context with uncertain or weaker response to PNPLA3 silencing,Represents the caution that PNPLA3 silencing may behave differently in heterozygotes because wild-type PNPLA3 activity may remain beneficial.,PNPLA3_ROMEO_VALENTI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_CHOLESTEROL_SIRNA_MUSCLE_TOLERATED,negative_control_cholesterol_siRNA_extrahepatic_delivery_tolerated,extrahepatic_delivery_tolerability_reference,skeletal muscle knockdown with low liver-marker signal proxy,"Represents systemic cholesterol-conjugated, chemically modified siRNA delivery with measurable skeletal-muscle and diaphragm knockdown and no strong liver/kidney marker worsening signal.",ENGELBEEN_ALK4_MUSCLE_SIRNA_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_EXTRAHEPATIC_SIRNA_LIVER_EXPOSURE,context_control_extrahepatic_siRNA_with_liver_exposure,distribution_context_reference,extrahepatic muscle delivery plus measurable liver exposure/knockdown without being labeled as a hepatotoxicity-positive control,Represents the fact that lipid-conjugated systemic siRNAs can affect non-liver target tissues while still showing liver exposure; useful for separating delivery distribution from liver injury.,ENGELBEEN_ALK4_MUSCLE_SIRNA_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_PERSONALIZED_ASO_ACCEPTABLE_SAFETY_PROFILE,negative_control_patient_customized_splice_ASO_acceptable_safety,ASO_platform_safety_workflow_reference,splice-modulating ASO workflow with low direct hepatotoxicity signal and explicit monitoring/toxicology context,"Represents a customized 2prime-MOE phosphorothioate ASO workflow with off-target screening, preclinical toxicology, intrathecal dosing, and no serious adverse events reported in the N-of-1 context; used only as safety-workflow context, not liver-efficacy evidence.",KIM_MILASEN_CUSTOM_ASO_2019,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_CUSTOM_ASO_TOX_WORKFLOW,context_control_custom_ASO_design_and_toxicology_workflow,translational_workflow_reference,"patient-specific ASO design, fibroblast validation, animal toxicology, dose escalation, and clinical monitoring are represented as workflow variables rather than hepatotoxicity positives","Represents the translational pipeline from genomic diagnosis and splice-defect identification to ASO design, in vitro validation, toxicology, dosing, PK, and monitoring.",KIM_MILASEN_CUSTOM_ASO_2019,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_GALNAC_ASO_NAFLD_TARGETED_LIVER_SAFE_WINDOW,negative_control_GalNAc_ASO_metabolic_liver_targeted_safe_window,hepatocyte_targeted_ASO_metabolic_benefit_reference,"metabolic-target benefit with low generated ALT/AST/GGT, low IFN response, and low kidney-injury proxy",Represents a GalNAc-conjugated ASO context with improved hepatocyte targeting and specificity for metabolic liver disease targets.,KEATING_ASO_OBESITY_NAFLD_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_HIGH_AFFINITY_GAPMER_HEPATOTOX_SEQUENCE_MOTIF,positive_control_high_affinity_gapmer_sequence_motif_hepatotoxicity,ASO_sequence_chemistry_hepatic_injury_reference,"higher hepatic-injury, off-target, RNase-H1 promiscuity, and ALT/AST/GGT proxies","Represents known ASO-development cautions: high-affinity gapmer chemistry, sequence-motif toxicity, and liver enzyme monitoring signals.",KEATING_ASO_OBESITY_NAFLD_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ASO_TYPE_I_IFN_OFFTARGET,context_control_ASO_type_I_interferon_offtarget_response,immune_offtarget_response_reference,type-I-interferon/off-target response context separated from direct hepatocyte cytotoxicity,"Represents ASO off-target immune-response context described for some ASO sequences and tissues, useful for distinguishing liver injury from immune confounding.",KEATING_ASO_OBESITY_NAFLD_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_LNA_GAPMER_SEQUENCE_REDESIGN_LOW_TOX,negative_control_LNA_gapmer_sequence_redesign_low_toxicity,sequence_modification_low_risk_redesign_reference,low generated ALT/AST proxy despite LNA/PS gapmer context because sequence-motif risk is reduced,Represents the concept that small sequence/redesign changes can lower hepatotoxic potential while preserving an oligo design family.,HAGEDORN_LNA_HEPATOTOX_RF_2013,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_LNA_GAPMER_SEQUENCE_PATTERN_HIGH_TOX,positive_control_LNA_gapmer_sequence_pattern_high_toxicity,sequence_modification_high_risk_reference,high generated ALT/AST proxy and high sequence-modification hepatotoxicity probability,Represents LNA-modified phosphorothioate gapmer designs whose sequence and modification pattern predict high hepatotoxic potential.,HAGEDORN_LNA_HEPATOTOX_RF_2013,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_DISTANCE_LIMITED_SEQUENCE_TOX_PREDICTION,context_control_sequence_toxicity_prediction_distance_limit,model_applicability_domain_reference,prediction confidence is reduced when sequence/edit-distance context is far from the training-like region,Represents the applicability-domain concept that sequence-toxicity prediction is stronger near training-like oligo designs and weaker farther away.,HAGEDORN_LNA_HEPATOTOX_RF_2013,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_HSD17B13_RAPIROSIRAN_NO_DILI_PD,negative_control_clinical_GalNAc_siRNA_no_DILI_PD_response,HSD17B13_GalNAc_siRNA_clinical_PD_safety_reference,robust HSD17B13 mRNA knockdown with no generated drug-induced liver injury signal and numerically lower ALT/AST context,Represents rapirosiran-like GalNAc-siRNA clinical low-hepatotoxicity reference for MASH with liver target knockdown.,RAPIROSIRAN_SANYAL_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_HSD17B13_HEPATITIS_E_CONFOUNDED_ALT_AST,context_control_non_drug_transaminase_confounding,separate_drug_signal_from_intercurrent_hepatitis_event,ALT/AST event is labeled as confounded/non-treatment-related rather than assigned to oligo hepatotoxicity,Represents the need to distinguish oligo-driven DILI from intercurrent liver infections or unrelated clinical events.,RAPIROSIRAN_SANYAL_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_HSD17B13_PLACEBO_MASH_ALT_AST_REFERENCE,context_control_MASH_placebo_liver_enzyme_reference,background_MASH_ALT_AST_variability_reference,background ALT/AST and NAS variability without active HSD17B13 knockdown,Represents MASH disease-background variability and placebo comparator context for interpreting generated clinical liver readouts.,RAPIROSIRAN_SANYAL_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_VIR2218_ESCPLUS_LOW_ALT,negative_control_ESCplus_GalNAc_siRNA_low_ALT,seed_region_modified_siRNA_hepatic_safety_reference,"low ALT proxy, reduced seed-mediated off-target proxy, retained on-target activity context",Represents VIR-2218-like ESC+ GalNAc-siRNA context with glycol nucleic acid seed-region modification and lower ALT elevation signal relative to the parent ALN-HBV context.,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_ALNHBV_SEED_OFFTARGET_ALT,positive_control_parent_ESC_siRNA_seed_offtarget_ALT,parent_siRNA_ALT_elevation_reference,higher seed-mediated off-target proxy and higher ALT elevation proxy,Represents ALN-HBV parent molecule context where ALT elevations were more pronounced than with VIR-2218 in mouse and healthy-volunteer comparisons.,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,context_control_clinical_antiviral_PD_not_hepatotoxicity_positive,HBsAg_reduction_and_PD_durability_reference,dose-dependent HBsAg reduction with generally encouraging hepatic safety context,"Represents two-dose VIR-2218 clinical cHBV context: HBsAg reduction, prolonged pharmacodynamic effect, and ALT monitoring separated from direct DILI labeling.",GANE_VIR2218_ALNHBV_HBV_RNAI_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_ZILEBESIRAN_GALNAC_AGT_PLATFORM_LOW_HEPATIC_INJURY,negative_platform_context_control,GalNAc-siRNA hepatic AGT knockdown with long-duration PD and no direct hepatotoxicity signal encoded,,,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,,dbbun_generated,CC BY 4.0,low_hepatotoxicity_context,"Represents zilebesiran-like hepatocyte-targeted AGT siRNA as a low direct-hepatotoxicity platform context, while tracking systemic RAAS safety separately.",,,,
+CTRL_CONTEXT_ZILEBESIRAN_RAAS_HYPERKALEMIA_RENAL_MONITORING,systemic_safety_context_control,"RAAS-suppression safety-monitoring context including hyperkalemia, hypotension, and renal-function changes",,,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,,dbbun_generated,CC BY 4.0,systemic_monitoring_not_primary_hepatotoxicity,"Keeps hyperkalemia, hypotension, and eGFR/creatinine monitoring separate from hepatotoxicity so the dataset does not confuse systemic pharmacology with liver injury.",,,,
+CTRL_CONTEXT_ZILEBESIRAN_LONG_PD_ENDOSOMAL_DEPOT,pharmacodynamic_durability_context_control,long-duration GalNAc-siRNA hepatocyte endosomal-depot and RISC-recycling context,,,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,,dbbun_generated,CC BY 4.0,durable_PD_context,"Represents prolonged siRNA effect from hepatocyte uptake, endosomal storage, and RISC-mediated target mRNA degradation.",,,,
+CTRL_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,negative_or_low_toxicity_mechanistic_control,GalNAc-siRNA with tolerated position-14 guide-strand bulge and preserved target repression,,"Represents a tolerated guide-strand bulge context with receptor-mediated GalNAc uptake and target repression, without adding direct hepatotoxicity signal.",HAUPTMANN_SIRNA_BULGES_GALNAC_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,low_hepatotoxicity_with_preserved_on_target_activity,,,,,
+CTRL_POS_TERMINAL_BULGE_OFFTARGET_REPRESSION_RISK,positive_offtarget_risk_control,Degenerate target-site / terminal guide-strand bulge off-target repression risk,,Represents the finding that short bulges or nucleotide omissions near guide termini can still support reporter repression and therefore should be tracked as off-target prediction risk.,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,higher_offtarget_prediction_risk_without_direct_hepatotoxicity_claim,,,,,
+CTRL_CONTEXT_SEED_REGION_BULGE_ACTIVITY_LOSS,context_activity_loss_control,Seed-region guide-strand bulge context with reduced siRNA activity,,"Represents reduced activity when guide-strand bulges are positioned in seed-region contexts, useful for distinguishing loss of efficacy from toxicity.",HAUPTMANN_SIRNA_BULGES_GALNAC_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,lower_on_target_activity_context,,,,,
+CTRL_CONTEXT_FBLL1_HIGH_HCC_MALIGNANT_STATE,context_liver_cancer_malignant_state_control,High-FBLL1 malignant hepatocyte / HCC tumor-niche context,,"Represents FBLL1 enrichment in malignant hepatocytes and tumor regions, useful for liver-disease context annotation without treating this as direct oligonucleotide hepatotoxicity.",XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,higher_HCC_malignant_context_not_direct_oligotox_signal,,,,,
+CTRL_NEG_FBLL1_SIRNA_KNOCKDOWN_HCC_GROWTH_SUPPRESSION,negative_growth_context_control,siRNA-mediated FBLL1 knockdown suppresses HCC proliferation and colony formation,,"Represents FBLL1-targeting research siRNA as a functional knockdown context that decreases HCC growth phenotypes, separating RNAi functional effect from hepatotoxicity.",XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,lower_HCC_growth_context_with_research_siRNA_knockdown,,,,,
+CTRL_CONTEXT_FBLL1_CMYC_EGFR_MAPK_ACTIVATION,context_oncogenic_signaling_control,FBLL1-associated c-Myc / EGFR ligand / MAPK activation context,,"Represents transcriptional and protein-level oncogenic signaling context linked to FBLL1 overexpression, including c-Myc, EGFR ligands, p-EGFR and p-ERK.",XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,higher_oncogenic_signaling_context_not_direct_hepatotoxicity,,,,,
+CTRL_NEG_GALNAC_LNP_SIMKK4_BIOCOMPATIBLE_LOW_HEMOLYSIS,negative_delivery_biocompatibility_control,GalNAc-LNP-siMKK4 biocompatible hepatocyte-targeted delivery context,,"Represents the reported low hemolysis, low in vitro cytotoxicity, stable GalNAc-LNP-siMKK4 formulation, and hepatocyte-targeted uptake context rather than an oligo hepatotoxicity signal.",ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,low_direct_hepatotoxicity_delivery_biocompatible_context,,,,,
+CTRL_CONTEXT_GALNAC_LNP_SIMKK4_ACLF_REGENERATION,context_liver_regeneration_rescue_control,GalNAc-LNP-siMKK4 promotes liver regeneration in CCl4/partial-hepatectomy ACLF model,,"Represents MKK4 knockdown, reduced p38/apoptosis signaling, increased MKK7-JNK/ATF2/ELK1 proliferative signaling, hepatocyte proliferation, and liver function recovery context.",ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,regeneration_rescue_and_liver_function_recovery_context,,,,,
+CTRL_POS_CCL4_PHX_ACLF_INJURY_CONTEXT,positive_liver_injury_model_context_control,CCl4 plus partial-hepatectomy acute-on-chronic liver failure injury context,,"Represents the injured liver model background used to evaluate regeneration rescue; this is a high liver-injury context control, not evidence that the oligonucleotide delivery system itself is hepatotoxic.",ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,high_background_liver_injury_low_regeneration_without_effective_siMKK4,,,,,
+CTRL_POS_OGT_SEV_LSEC_CAPILLARIZATION_MASLD,positive_context_lipotoxic_hepatocyte_sEV,MASLD_LSEC_capillarization_and_ALT_AST_stress_context,"high OGT/O-GlcNAc/HNF1a-Ang2 signaling with LSEC defenestration, higher ALT/AST context, and MASLD progression proxy",Represents lipotoxic hepatocyte-derived sEV carrying OGT and promoting LSEC capillarization through HNF1a O-GlcNAcylation and Ang-2 activation.,WANG_OGT_SEV_LSEC_MASLD_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_OGT_KNOCKDOWN_SEV_REDUCED_CAPILLARIZATION,negative_mechanistic_context_OGT_depleted_sEV,reduced_OGT_sEV_cargo_and_reduced_LSEC_capillarization,lower OGT/O-GlcNAc/Ang-2 context and reduced capillarization relative to OGT-high sEV context,"Represents OGT knockdown in lipotoxic hepatocyte-derived sEV attenuating Ang-2 induction, sinusoidal defenestration, and MASLD worsening.",WANG_OGT_SEV_LSEC_MASLD_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_BAGN_OGLCNAC_INHIBITOR_MASLD_RESCUE,therapeutic_context_OGlcNAc_inhibitor_rescue,BAGN_reduces_HNF1a_OGlcNAcylation_Ang2_LSEC_capillarization_and_MASLD_progression,"dose-dependent reduction in O-GlcNAcylation, Ang-2, LSEC capillarization, ALT/AST, TG, inflammation, lipid deposition, collagen deposition, and alpha-SMA context",Represents BAGN inhibition of O-GlcNAcylation as a rescue context in HFD-induced MASLD mice.,WANG_OGT_SEV_LSEC_MASLD_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_HBX_MALAT1_IGF2BP3_HCC_ONCOGENIC_STATE,positive_context_control,HBx_MALAT1_m6A_IGF2BP3_oncogenic_HCC_state,,,DU_MALAT1_HBV_HCC_ASO_2025,,dbbun_generated,CC BY 4.0,higher_HCC_context_signal,"Models the high-risk HBV/HBx-related HCC context in which MALAT1 is upregulated, m6A-modified, stabilized/exported by IGF2BP3, and associated with proliferation, invasion, EMT, and poor prognosis.",,,,
+CTRL_NEG_ASO_MALAT1_HBV_HCC_TUMOR_SUPPRESSION,negative_or_rescue_control,ASO_MALAT1_suppression_of_HBV_related_HCC_progression,,,DU_MALAT1_HBV_HCC_ASO_2025,,dbbun_generated,CC BY 4.0,lower_HCC_context_signal_after_ASO_MALAT1,Models the ASO-MALAT1 rescue/intervention context where MALAT1 targeting suppresses xenograft and orthotopic HBV-related HCC progression and reduces EMT/intrahepatic spread signals.,,,,
+CTRL_CONTEXT_MALAT1_M6A_IGF2BP3_SHUTTLING,mechanistic_context_control,m6A_site_dependent_MALAT1_IGF2BP3_binding_and_cytoplasmic_export,,,DU_MALAT1_HBV_HCC_ASO_2025,,dbbun_generated,CC BY 4.0,mechanistic_context_not_direct_toxicity,"Captures the mechanism that METTL3/METTL14/WTAP-mediated m6A at MALAT1 sites 6021A and 7265A supports IGF2BP3 binding, MALAT1 stabilization, and nuclear-cytoplasmic shuttling.",,,,
+CTRL_POS_CD133_CSC_MASLD_HCC_MKI_RESISTANCE,positive_context_control,CD133_positive_CSC_MASLD_HCC_multikinase_inhibitor_resistance_state,,,PAN_CD133_MASLD_HCC_SIRNA_2025,,dbbun_generated,CC BY 4.0,higher_stemness_resistance_and_tumor_context_signal,"Models the high-risk MASLD-HCC context in which CD133-positive cancer stem cells show self-renewal, tumor-initiating capacity, Wnt/beta-catenin activation, and resistance to multikinase inhibitors.",,,,
+CTRL_NEG_VNP_SICD133_MKI_TUMOR_SUPPRESSION,negative_or_rescue_control,VNP_siCD133_plus_sorafenib_or_lenvatinib_tumor_suppression,,,PAN_CD133_MASLD_HCC_SIRNA_2025,,dbbun_generated,CC BY 4.0,lower_tumor_context_signal_after_siCD133_combination_therapy,"Models the therapeutic rescue context where nanoparticle-delivered CD133 siRNA sensitizes MASLD-HCC to sorafenib or lenvatinib and reduces tumor burden, Ki67, and Wnt/beta-catenin signaling.",,,,
+CTRL_CONTEXT_CD133_MYH9_BCATENIN_STEMNESS,mechanistic_context_control,CD133_MYH9_active_beta_catenin_stemness_axis,,,PAN_CD133_MASLD_HCC_SIRNA_2025,,dbbun_generated,CC BY 4.0,mechanistic_context_not_direct_toxicity,Captures the mechanism where CD133 interacts with MYH9 to stabilize active beta-catenin and propagate Wnt/beta-catenin signaling in MASLD-HCC cancer stem cells.,,,,
+CTRL_NEG_GALNAC_RBC_EV_HEPATOCYTE_TARGETED_SAFE,negative_delivery_safety_control,ctrl_neg_galnac_rbc_ev_hepatocyte_targeted_safe,,,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,,dbbun_generated,CC BY 4.0,high_hepatocyte_targeting_low_direct_delivery_toxicity,GalNAc-modified RBC-EV ASGPR hepatocyte targeting with low systemic toxicity context.,,,,
+CTRL_NEG_RBC_EV_GALNAC_MIR155_ASO_ALF_RESCUE,negative_or_rescue_control,ctrl_neg_rbc_ev_galnac_mir155_aso_alf_rescue,,,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,,dbbun_generated,CC BY 4.0,lower_ALF_liver_injury_and_cell_death_signal,"RBC-EV/GalNAc-miR-155-ASO rescue in acute liver injury with lower ALT/AST, inflammation, and PANoptosis context.",,,,
+CTRL_CONTEXT_GALNAC_RBC_EV_PJ34_NAFLD_RESCUE,therapeutic_context_control,ctrl_context_galnac_rbc_ev_pj34_nafld_rescue,,,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,,dbbun_generated,CC BY 4.0,lower_steatosis_PAR_and_liver_injury_signal,GalNAc-RBC-EVs/PJ34 PARP-1/PAR reduction and NAFLD steatosis rescue context.,,,,
+CTRL_CONTEXT_GALNAC_RBC_EV_RAB7_SIRNA_PJ34_HCC,combination_delivery_context_control,ctrl_context_galnac_rbc_ev_rab7_sirna_pj34_hcc,,,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,,dbbun_generated,CC BY 4.0,higher_drug_retention_and_HCC_tumor_suppression_context,RBC-EV/GalNAc-Rab7-siRNA/PJ34 HCC co-delivery with drug-retention and tumor-suppression context.,,,,
+CTRL_CONTEXT_MELD_PLUS_HIGH_RISK_CIRRHOSIS,clinical_high_risk_context_control,ctrl_context_meld_plus_high_risk_cirrhosis,,,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,,dbbun_generated,CC BY 4.0,higher_clinical_liver_severity_and_mortality_risk_context,"High MELD-Plus-like cirrhosis risk state with low albumin, high bilirubin/INR/creatinine/WBC, hyponatremia, longer admission, and high predicted post-discharge mortality.",,,,
+CTRL_NEG_MELD_PLUS_LOW_RISK_CIRRHOSIS,clinical_low_risk_context_control,ctrl_neg_meld_plus_low_risk_cirrhosis,,,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,,dbbun_generated,CC BY 4.0,lower_clinical_liver_severity_context,Lower MELD-Plus-like cirrhosis risk state with more favorable structured laboratory profile and lower predicted post-discharge mortality.,,,,
+CTRL_CONTEXT_MELD_PLUS_EMR_VARIABLES,clinical_prediction_schema_context_control,ctrl_context_meld_plus_emr_variables,,,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,,dbbun_generated,CC BY 4.0,schema_context_for_clinical_liver_outcome_prediction,"MELD-Plus variable-set context: MELD-Na components plus albumin, total cholesterol, WBC, age, and length of stay.",,,,
+CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS,positive_liver_stress_context,,,,,,dbbun_generated,CC BY 4.0,high_oxidative_liver_stress,,MA_FORMONONETIN_ALDH2_ALD_2025,"Alcohol-related liver injury context with acetaldehyde accumulation, ROS, lipid peroxidation, mitochondrial dysfunction, ALT/AST elevation, and fibrosis/liver-injury features.",,
+CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION,negative_hepatoprotective_context,,,,,,dbbun_generated,CC BY 4.0,reduced_aldehyde_oxidative_liver_stress,,MA_FORMONONETIN_ALDH2_ALD_2025,"Formononetin-like rescue context with ALDH2 activation, lower acetaldehyde/4-HNE/TBARS, restored GSH/GPX4/NAD/ATP, and improved mitochondrial/liver-injury measures.",,
+CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE,mechanistic_loss_of_rescue_context,,,,,,dbbun_generated,CC BY 4.0,mechanistic_dependency_context,,MA_FORMONONETIN_ALDH2_ALD_2025,AAV8 siRNA knockdown context in which loss of ALDH2 or Nrf2 reduces the formononetin-like rescue signal.,,
+CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL,negative_systemic_siRNA_nanoparticle_safety_context,,,,,,dbbun_generated,CC BY 4.0,low_direct_hepatotoxicity_signal,,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,Calcium phosphate hybrid nanoparticle siRNA context with low hemolysis and ALT/AST values remaining in a standard/non-injury range in treated animals.,,
+CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTREATMENT,therapeutic_combination_context,,,,,,dbbun_generated,CC BY 4.0,combination_efficacy_context,,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,"HOXB7 siRNA plus tamoxifen cotreatment context with tumor growth control, improved survival in advanced tumor animals, and systemic safety monitoring.",,
+CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOSOMAL_ESCAPE,delivery_design_context,,,,,,dbbun_generated,CC BY 4.0,delivery_mechanism_context,,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,"Calcium phosphate/PEG-pGlu nanoparticle design context with nanoscale size, siRNA encapsulation, acid-pH destabilization, and endosomal escape rationale.",,
+CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_TOX,negative_sEV_siRNA_hepatic_delivery_safety_context,,,,,,dbbun_generated,CC BY 4.0,low_systemic_toxicity_with_hepatic_RNAi_activity,,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,"PMEVL-engineered sEVs loaded with Pcsk9 siRNA suppress hepatic Pcsk9, restore LDLR, reduce LDL-C/total cholesterol, and preserve normal ALT/AST and organ histology context.",,
+CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_LOADING,RNA_loading_mechanism_context,,,,,,dbbun_generated,CC BY 4.0,high_sEV_RNA_loading_efficiency,,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,"N-myristoylation-dependent PMEVL loading context for chemically synthesized siRNA/miRNA, endogenous miRNA, pri-miR-30a-based siRNA, multiple siRNAs, and mRNA cargoes into sEVs.",,
+CTRL_CONTEXT_PMEVL_ERK_AMPK_ANXA2_ESCRT_MECHANISM,sEV_biogenesis_and_sorting_mechanism_context,,,,,,dbbun_generated,CC BY 4.0,mechanistic_sEV_biogenesis_and_RNA_sorting_context,,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,"PMEVL mechanism context involving ERK1/2 activation, AMPK-autophagy inhibition, ANXA2/AGO2-mediated RNA recruitment, and ALIX/TSG101 ESCRT-mediated cargo sorting.",,
+CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FRAMEWORK,preclinical_safety_framework_context,,,,,,dbbun_generated,CC BY 4.0,framework_context_not_intrinsic_toxicity,,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,"General therapeutic-oligonucleotide safety framework separating sequence/hybridization-dependent on/off-target effects, sequence-independent Cmax effects, and sequence-dependent hybridization-independent liver/kidney/inflammatory toxicities.",,
+CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK,positive_sequence_dependent_gapmer_hepatotoxicity_risk_context,,,,,,dbbun_generated,CC BY 4.0,higher_liver_toxicity_risk,,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,High-affinity PS gapmer sequence/modification patterns can show liver-toxicity risk independent of intended target knockdown or total liver concentration; sequence motifs and in vitro screens help remove risky candidates.,,
+CTRL_CONTEXT_HYBRIDIZATION_OFFTARGET_SCREENING,hybridization_dependent_offtarget_screening_context,,,,,,dbbun_generated,CC BY 4.0,offtarget_risk_assessment_context,,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,"Safety assessment should include transcriptome-wide in silico off-target screening, in vitro potency confirmation for candidate off-target transcripts, and consequence assessment when margins are insufficient.",,
+CTRL_CONTEXT_GALNAC_PRODUCTIVE_UPTAKE_HEPATOCYTE,GalNAc_productive_uptake_hepatocyte_context,,,,,,dbbun_generated,CC BY 4.0,improved_hepatocyte_productive_uptake_context,,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,"GalNAc conjugation improves hepatocyte productive uptake of ASOs and siRNAs through ASGR/ASGPR-mediated delivery, changing potency, dose, distribution, and safety-assessment context.",,
+CTRL_CONTEXT_CMAX_COMPLEMENT_COAGULATION_MONITORING,Cmax_dependent_complement_coagulation_context,,,,,,dbbun_generated,CC BY 4.0,Cmax_monitoring_context,,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,"Some PS-ASO effects, including coagulation-time prolongation and alternative complement activation, are plasma Cmax-related, transient, and should be modeled separately from sequence-specific hepatotoxicity.",,
+CTRL_POS_IFNA_DISULFIDPTOSIS_HCC,positive_cell_death_context,,,,,,dbbun_generated,CC BY 4.0,increased_disulfide_stress_and_cell_death,Provides a positive noncanonical liver-cell-death context that can help distinguish oxidative/disulfide stress from classic oligo sequence toxicity.,,"IFN-alpha-treated HepG2/Huh7-like positive context with disulfide-linked protein aggregation, NADPH depletion, and F-actin collapse.",,
+CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE,negative_rescue_context,,,,,,dbbun_generated,CC BY 4.0,reduced_disulfide_stress,Provides a rescue/control row for disulfide-bond stress phenotypes.,,"D-penicillamine rescue context that partially reverses IFN-alpha-associated disulfide accumulation, NADPH depletion, and F-actin collapse.",,
+CTRL_CONTEXT_SLC7A11_KD_IFNA_AGGRAVATION,mechanistic_context,,,,,,dbbun_generated,CC BY 4.0,SLC7A11_not_sufficient_to_explain_IFN_alpha_disulfidptosis,Encodes the distinction between canonical SLC7A11-associated disulfidptosis and the paper's proposed SLC7A11-independent or partially independent mechanism.,,SLC7A11 siRNA knockdown context in which IFN-alpha-associated high-molecular-weight protein aggregation is aggravated rather than reduced.,,
+CTRL_CONTEXT_IFNA_ISG_B2M_USP18_PSME1,candidate_gene_context,,,,,,dbbun_generated,CC BY 4.0,candidate_interferon_stress_genes_upregulated,Adds candidate interferon-stimulated-gene context for liver cancer cell stress and disulfidptosis-associated phenotype modeling.,,"IFN-alpha candidate-gene context with B2M, USP18, and PSME1 upregulation, including PSME1 protein-level increase.",,
+CTRL_NEG_GALNAC_ESC_SIRNA_PLATFORM_LOW_TOX,negative_platform_safety_control,,,,,,dbbun_generated,CC BY 4.0,low_hepatotoxicity_with_platform_safety_monitoring,Represents the nonadverse platform-safety pattern for selected GalNAc-siRNAs in short-term rat/monkey toxicology.,,"ESC GalNAc-siRNA platform context with hepatocyte-targeted ASGPR uptake, limited PS content, 2prime-OMe/2prime-F chemistry, and low systemic toxicity at screened doses.",,
+CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX,positive_sequence_offtarget_hepatotoxicity_control,,,,,,dbbun_generated,CC BY 4.0,increased_seed_offtarget_hepatotoxicity,Encodes the key GalNAc-siRNA safety-screening failure mode: seed-mediated off-target hepatotoxicity at supratherapeutic dose.,,GalNAc-siRNA seed-region off-target context associated with rat hepatocellular degeneration/coagulative necrosis and liver-enzyme elevation at exaggerated doses.,,
+CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION,distribution_accumulation_context,,,,,,dbbun_generated,CC BY 4.0,organ_distribution_and_accumulation_monitoring,Adds the platform pattern of liver/kidney/RES findings rather than treating every histologic finding as direct adverse hepatotoxicity.,,"GalNAc-siRNA distribution context with pharmacodynamic liver exposure, kidney elimination, and reticuloendothelial-system histology findings that are often nonadverse and reversible.",,
+CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPONSE,clinical_PCSK9_response_context,,,,,,dbbun_generated,CC BY 4.0,PCSK9_knockdown_lipid_and_vascular_response,"Adds clinical GalNAc-siRNA response context for PCSK9 targeting, without treating lipid efficacy as hepatotoxicity.",,Inclisiran-treated familial-hypercholesterolemia context with LDL-C/ApoB/non-HDL-C/Lp(a) reductions and PWV improvement over six months.,,
+CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD,negative_clinical_liver_enzyme_monitoring_control,,,,,,dbbun_generated,CC BY 4.0,stable_ALT_AST_CPK_monitoring,Provides clinical tolerability/liver-enzyme monitoring context for a GalNAc-siRNA PCSK9 therapeutic.,,Inclisiran real-world monitoring context where liver and muscle enzymes remain similar before and after treatment.,,
+CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW,delivery_platform_context,,,,,,dbbun_generated,CC BY 4.0,hepatocyte_targeted_productive_uptake_context,Encodes the core GalNAc delivery mechanism that explains why liver-targeted oligonucleotides can be dosed at lower levels than unconjugated or LNP-formulated alternatives.,,General GalNAc-ASGPR hepatocyte delivery context for liver-targeted ASO/siRNA therapeutics with rapid receptor-mediated uptake and intracellular endosomal processing.,,
+CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY,ASO_hepatocyte_uptake_potency_context,,,,,,dbbun_generated,CC BY 4.0,increased_hepatocyte_uptake_and_lower_required_dose,Adds the review's ASO delivery message: GalNAc conjugation changes cellular liver distribution and can improve clinical potency by roughly an order of magnitude or more.,,GalNAc-ASO context where liver uptake shifts toward hepatocytes and potency improves relative to naked ASO for hepatocyte targets.,,
+CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY,siRNA_seed_region_safety_mitigation_context,,,,,,dbbun_generated,CC BY 4.0,reduced_seed_offtarget_hepatotoxicity_risk,Connects GalNAc-siRNA chemistry optimization to lower off-target toxicity risk and lower dose exposure.,,GalNAc-siRNA ESC/ESC+ chemistry context with seed-region off-target mitigation by destabilizing seed interactions while maintaining potency.,,
+CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY,reversal_safety_context,,,,,,dbbun_generated,CC BY 4.0,reversible_RISC_bound_siRNA_activity_context,Adds a safety-control concept for long-duration siRNA pharmacology: deliberate reversal of target silencing after GalNAc-siRNA dosing.,,Reversir-like GalNAc-conjugated oligonucleotide antidote concept for reversing siRNA silencing if toxicity is encountered.,,
+CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM,siRNA_mechanism_context,,,,,,dbbun_generated,CC BY 4.0,sequence_specific_RISC_mediated_target_knockdown,Encodes the mechanistic backbone needed to interpret therapeutic siRNA potency and off-target effects.,,"Canonical siRNA mechanism context: guide-strand loading into AGO2/RISC, passenger-strand removal, complementary mRNA cleavage, and reduced target-protein synthesis.",,
+CTRL_CONTEXT_SIRNA_PKPD_BARRIERS,siRNA_pharmacology_barrier_context,,,,,,dbbun_generated,CC BY 4.0,low_unmodified_siRNA_exposure_without_modification_or_delivery,"Adds baseline PK/PD barriers that justify GalNAc conjugation, LNP encapsulation, and chemical stabilization.",,"Naked siRNA pharmacology-barrier context: poor tissue penetration, endosomal escape limitation, nuclease degradation, rapid renal clearance, and need for stabilization/delivery systems.",,
+CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCREENING,immune_and_offtarget_safety_context,,,,,,dbbun_generated,CC BY 4.0,flag_for_offtarget_and_immunostimulatory_risk_assessment,Adds safety interpretation for distinguishing intended knockdown from off-target or immune-mediated toxicity.,,"siRNA safety-screening context for immune activation, TLR/cytokine responses, incomplete pairing, seed-region off-target silencing, and RISC/miRNA-pathway competition.",,
+CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION,approved_clinical_siRNA_context,,,,,,dbbun_generated,CC BY 4.0,clinically_translated_liver_targeted_siRNA_platform_context,Connects generated OligoTox records to clinically validated liver-directed siRNA design and monitoring concepts.,,"Approved and clinical-stage siRNA landscape context including GalNAc-delivered givosiran, lumasiran, inclisiran, and other liver-targeted siRNA programs.",,
+CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,positive_control,,,,,,dbbun_generated,CC BY 4.0,,,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,High-risk LNA gapmer-like ASO control with many predicted/potent off-target effects and elevated ALT/AST/liver-weight signals.,high_hepatotoxicity,
+CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX,negative_control,,,,,,dbbun_generated,CC BY 4.0,,,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,Cleaner/selective LNA gapmer-like ASO control with low predicted off-target burden and minimal ALT/AST signal.,low_hepatotoxicity,
+CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN,assay_context_control,,,,,,dbbun_generated,CC BY 4.0,,,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,Context control representing a streamlined acute mouse screen using plasma ALT/AST and liver-weight endpoints to rank ASO hepatotoxicity.,screening_context,
+CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY,computational_context_control,,,,,,dbbun_generated,CC BY 4.0,,,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,Context control representing in silico OTE prediction plus transcriptome-wide selectivity confirmation as a mitigation strategy.,selectivity_context,
+CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,negative_control,,,,,,dbbun_generated,CC BY 4.0,,,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,LNP-delivered AGO1 LNA-gapmer ASO-like control with therapeutic knockdown context and no modeled ALT/AST hepatotoxicity signal.,low_hepatotoxicity_with_liver_function_monitoring,
+CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,mechanism_context_control,,,,,,dbbun_generated,CC BY 4.0,,,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,Context control representing endothelial nuclear AGO1 interaction with NF-kB/p65 and pro-inflammatory gene activation.,vascular_inflammation_context,
+CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,disease_model_context_control,,,,,,dbbun_generated,CC BY 4.0,,,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,"Context control representing AAV9-PCSK9/high-fat-high-cholesterol stress with lipid profile, liver function, steatosis, fibrosis, and atherosclerosis endpoints.",metabolic_liver_vascular_context,
+CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,cell_interaction_context_control,,,,,,dbbun_generated,CC BY 4.0,,,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,Context control representing endothelial-hepatocyte paracrine signaling affecting inflammatory and lipid-metabolism gene programs.,paracrine_liver_metabolism_context,
+CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION,negative_control_systemic_ASO_tolerability,,,,,,dbbun_generated,CC BY 4.0,,,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,Systemically administered GYS1 PS-cEt gapmer ASO context with no modeled ALT/AST elevation signal and no major organ-weight toxicity signal.,low_hepatotoxicity_with_systemic_tolerability_monitoring,
+CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE,therapeutic_mechanism_context_control,,,,,,dbbun_generated,CC BY 4.0,,,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,Context control representing Gys1 RNase-H1 gapmer ASO substrate-reduction therapy reducing glycogen accumulation in Pompe muscle.,target_knockdown_and_substrate_reduction_context,
+CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION,combination_therapy_context_control,,,,,,dbbun_generated,CC BY 4.0,,,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,"Context control representing GYS1 ASO plus recombinant GAA enzyme replacement therapy, combining reduced new glycogen synthesis with enhanced clearance.",combination_therapy_translatability_context,
+CTRL_CONTEXT_GYS1_GYS2_ISOFORM_SPECIFICITY,specificity_context_control,,,,,,dbbun_generated,CC BY 4.0,,,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,Context control representing isoform-specific ASO design challenge for muscle GYS1 versus liver GYS2 homology.,sequence_specificity_and_offtarget_design_context,
+CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_ALT_ALP_BILI,positive_control_cholestatic_liver_injury,,,,,,dbbun_generated,CC BY 4.0,,,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,"Positive hepatobiliary injury context representing DDC-induced cholestasis with elevated ALP, ALT, bilirubin, cholesterol, portal inflammation, ductular reaction, and fibrosis.",,high_cholestatic_liver_injury_signal
+CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLUTION,negative_control_recovery_resolution,,,,,,dbbun_generated,CC BY 4.0,,,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,Recovery/resolution context representing return toward baseline liver chemistry and reduced cholangiocyte inflammatory signaling after DDC withdrawal.,,resolved_or_low_cholestatic_liver_injury_signal
+CTRL_CONTEXT_CX3CL1_CX3CR1_MACROPHAGE_RECRUITMENT,mechanism_context_control,,,,,,dbbun_generated,CC BY 4.0,,,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,Context control representing cholangiocyte CX3CL1 expression and periportal CX3CR1-positive macrophage recruitment during cholestatic injury.,,cholangiocyte_macrophage_interaction_context
+CTRL_CONTEXT_NFYA_TGFB1_CHOLANGIOCYTE_FIBROSIS,mechanism_context_control,,,,,,dbbun_generated,CC BY 4.0,,,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,Context control representing NF-YA activation in cholangiocytes and siRNA NF-YA suppression reducing TGFβ1 expression in normal human cholangiocytes.,,cholangiocyte_fibrosis_TGFB1_context
+CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBLE_LIVER_SIGNAL,negative_control_low_sequence_dependent_AmNA_ASO_liver_signal,,,,,inferred_from_paper,dbbun_generated,CC BY 4.0,,,KANDA_PCDHA11_AMNA_ASO_2024,Generated hPCDHA11-2255-like AmNA-ASO control with lower modeled AST/ALT signal and strong recovery after treatment cessation.,low_to_moderate_reversible_liver_signal_with_target_knockdown_context,
+CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET_LIVER_SIGNAL,negative_control_lower_offtarget_AmNA_ASO_liver_signal,,,,,inferred_from_paper,dbbun_generated,CC BY 4.0,,,KANDA_PCDHA11_AMNA_ASO_2024,"Generated hPCDHA11-3319-like AmNA-ASO control representing lower off-target risk, target knockdown, antitumor activity, and reversible low-to-moderate liver-enzyme response.",lower_offtarget_burden_and_reversible_liver_signal,
+CTRL_POS_PCDHA11_AMNA_3969_SEQUENCE_DEPENDENT_LIVER_INJURY,positive_control_sequence_dependent_AmNA_ASO_hepatotoxicity,,,,,inferred_from_paper,dbbun_generated,CC BY 4.0,,,KANDA_PCDHA11_AMNA_ASO_2024,Generated hPCDHA11-3969-like AmNA-ASO positive control representing stronger sequence-dependent AST/ALT elevation and higher off-target/mismatch-burden context.,high_reversible_sequence_dependent_liver_injury_signal,
+CTRL_CONTEXT_PCDHA11_AMNA_OFFTARGET_MICROARRAY_SCREEN,context_control_offtarget_bioinformatics_microarray_screening,,,,,inferred_from_paper,dbbun_generated,CC BY 4.0,,,KANDA_PCDHA11_AMNA_ASO_2024,Context control for combined in silico mismatch search and microarray perturbation screening of AmNA-modified anti-PCDHA11 ASOs.,offtarget_screening_and_transcriptomic_perturbation_context,
+CTRL_CONTEXT_PCDHA11_KO_TARGET_SPECIFICITY_APOPTOSIS,context_control_target_specificity_and_apoptosis,,,,,inferred_from_paper,dbbun_generated,CC BY 4.0,,,KANDA_PCDHA11_AMNA_ASO_2024,Context control representing target-specificity evidence: attenuated ASO effect in PCDHA11-knockout cells and apoptosis/caspase response in parental PCDHA11-expressing cells.,target_specificity_and_on_target_pharmacology_context,
+CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE,positive_control_PS_ASO_DNA_damage_response_toxicity,PS_backbone_concentration_dependent_repair_enzyme_condensate_high_risk,"high PS-body/condensate formation, DNA-PKcs/ATM/PARP1 binding, checkpoint activation, HR suppression, and toxic DNA-lesion proxy",Represents a high-PS gapmer/ASO condition that activates DNA damage response without requiring DNA breaks.,HJELMGREN_PS_ASO_DDR_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY,negative_control_PO_backbone_low_DDR,phosphodiester_or_low_PS_backbone_contrast,low PS-body/filament formation and low repair-enzyme condensate activation,Represents the PS-backbone requirement by contrasting PO/low-PS oligo context with PS-ASO conditions.,HJELMGREN_PS_ASO_DDR_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ASO_REPAIR_PROTEIN_BINDING,mechanism_context_control_ASO_repair_protein_binding,DNA-PKcs_ATM_PARPs_binding_and_phase_separation_context,repair proteins bind ASO polymers and form nuclear condensate-like structures,Documents the mechanism layer connecting ASO chemistry to repair-enzyme activation and cellular toxicity.,HJELMGREN_PS_ASO_DDR_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNCTION_IMPROVED,negative_control_ROS_responsive_GalNAc_siRNA_liver_function_improvement,targeted_siRubicon_MASH_low_hepatotoxicity_liver_function_context,"Rubicon knockdown, increased lipophagy, reduced steatosis, lower generated ALT/AST, and higher albumin context",Represents disease-responsive hepatocyte-targeted siRNA delivery with liver-function improvement rather than intrinsic liver injury.,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGETING,delivery_context_control_ROS_GalNAc_hepatocyte_targeting,oxidative_stress_triggered_shell_disassembly_ASGPR_hepatocyte_targeting,"higher liver/MASH accumulation, ASGPR-mediated hepatocyte uptake, and lower non-parenchymal Rubicon suppression context",Represents the dual targeting mechanism: ROS-responsive liver activation plus GalNAc/ASGPR hepatocyte uptake.,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_PEI_NANOCARRIER_SAFETY_MONITORING,delivery_safety_context_control_PEI_nanocarrier,cationic_vector_and_offtarget_organ_retention_safety_monitoring,"delivery benefit with explicit monitoring of PEI-related cytotoxicity, organ distribution, immune clearance, ALT/AST, and albumin context",Represents the need to monitor cationic PEI and nanoparticle delivery risks even when therapeutic liver readouts improve.,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_SCPBNA2_ASO_LOW_HEPATOTOX_RETAINED_KD,negative_control_scpBNA2_gapmer_low_hepatotoxicity,negative_control_scpBNA2_gapmer_low_hepatotoxicity,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_LNA_BNA_ASO_HEPATOTOX_PARENT,positive_control_LNA_BNA_parent_ASO_hepatotoxicity,positive_control_LNA_BNA_parent_ASO_hepatotoxicity,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_REDUCED_PS_PO_LINKAGE_LOWER_ACTIVITY_RISK,context_control_reduced_PS_PO_linkage_tradeoff,context_control_reduced_PS_PO_linkage_tradeoff,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_SICYP2E1_LNP_APAP_ALT_AST_RESCUE,negative_control_siCyp2e1_LNP_APAP_rescue,negative_control_siCyp2e1_LNP_APAP_rescue,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,LIU_CYP2E1_LNP_APAP_AILI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_APAP_AILI_UNTREATED_HIGH_ALT_AST,positive_control_APAP_acute_liver_injury,positive_control_APAP_acute_liver_injury,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,LIU_CYP2E1_LNP_APAP_AILI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_DELAYED_SICYP2E1_LIMITED_EARLY_RESCUE_RECOVERY,context_control_delayed_siCyp2e1_timing_dependence,context_control_delayed_siCyp2e1_timing_dependence,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,LIU_CYP2E1_LNP_APAP_AILI_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_CHOLESTEROL_NANP_HEPATOCYTE_UPTAKE,delivery_context_control_cholesterol_NANP_hepatocyte_uptake,delivery_context_control_cholesterol_NANP_hepatocyte_uptake,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,KIM_NANP_LIPID_LIVER_TARGETING_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_TRIGALNAC_NANP_WEAK_ASGPR_UPTAKE,delivery_context_control_TriGalNAc_NANP_ASGPR_contrast,delivery_context_control_TriGalNAc_NANP_ASGPR_contrast,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,KIM_NANP_LIPID_LIVER_TARGETING_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_NANP_KUPFFER_SCAVENGER_ASSOCIATION,positive_control_NANP_Kupffer_macrophage_association,positive_control_NANP_Kupffer_macrophage_association,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper.,KIM_NANP_LIPID_LIVER_TARGETING_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_RNA_NP_NON_TARGETED_LOW_OFFTARGET,negative_control_non_targeted_RNA_nanoparticle_low_offtarget,negative_control_non_targeted_RNA_nanoparticle_low_offtarget,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_RNA_NP_MULTITARGET_HCC_ACTIVITY,context_control_RNA_nanoparticle_multitarget_HCC_activity,context_control_RNA_nanoparticle_multitarget_HCC_activity,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_RNA_NP_VERO_DOSE_WINDOW,context_control_RNA_nanoparticle_non_cancer_dose_window,context_control_RNA_nanoparticle_non_cancer_dose_window,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_DCA_ASIRNA_NO_VISIBLE_TOX_DURABLE_KD,negative_control_DCA_asiRNA_visible_tolerability_durable_knockdown,negative_control_DCA_asiRNA_visible_tolerability_durable_knockdown,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ASIRNA_SEED_OFFTARGET_REDUCTION,context_control_asymmetric_siRNA_seed_offtarget_reduction,context_control_asymmetric_siRNA_seed_offtarget_reduction,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_HEAVY_2F_PS_MODIFICATION_OFFTARGET_RISK,context_control_heavy_2primeF_PS_modification_offtarget_risk,context_control_heavy_2primeF_PS_modification_offtarget_risk,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_MULTIFUNCTIONAL_HDO_DELIVERY,context_control_multifunctional_HDO_delivery,context_control_multifunctional_HDO_delivery,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_HDO_SCRAMBLED_CONTROL,negative_control_HDO_scrambled_sequence,negative_control_HDO_scrambled_sequence,generated v1.0 control behavior,Focused benchmark/control for the encoded source paper and judging-criteria evidence layer.,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_AGT_GALNAC_SIRNA_SAFE_CANDIDATE,negative_control_AGT_GalNAc_siRNA_safe_candidate,negative_control_AGT_GalNAc_siRNA_safe_candidate,low ALT/AST/urea and favorable RNAseq off-target profile,Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_AGT_SIRNA_OFFTARGET_LIVER_KIDNEY_SIGNAL,positive_control_AGT_siRNA_offtarget_liver_kidney_signal,positive_control_AGT_siRNA_offtarget_liver_kidney_signal,elevated ALT/AST/urea and histopathology risk due to dose-dependent off-target transcript effects,Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ZILEBESIRAN_LIKE_COMPARATOR,context_control_Zilebesiran_like_AGT_siRNA_comparator,context_control_Zilebesiran_like_AGT_siRNA_comparator,"benchmark comparator for AGT knockdown, durability, and BP-reduction context",Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_CPG_ODN_MACROPHAGE_APAP_PROTECTION,negative_control_CpG_ODN_macrophage_APAP_protection,negative_control_CpG_ODN_macrophage_APAP_protection,reduced APAP injury through macrophage TLR9/IRG1/itaconate context,Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,QU_CPG_ODN_APAP_TLR9_IRG1_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_CPG_ODN_ACOD1_SIRNA_LOSS_OF_PROTECTION,positive_control_CpG_ODN_Acod1_siRNA_loss_of_protection,positive_control_CpG_ODN_Acod1_siRNA_loss_of_protection,loss of itaconate-mediated protection after Acod1/IRG1 interference,Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,QU_CPG_ODN_APAP_TLR9_IRG1_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ERBB2_APTAMER_PET_PK_BIODISTRIBUTION,context_control_ERBB2_aptamer_PET_PK_biodistribution,context_control_ERBB2_aptamer_PET_PK_biodistribution,organ PK/biodistribution and excretion context for oligonucleotide-based drugs,Focused v1.0 benchmark/control for source-specific judging-criteria demonstration.,PARK_ERBB2_APTAMER_PET_PK_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_PARENT_LNA_GAPMER_ALT_SIGNAL,positive_control_parent_LNA_gapmer_ALT_signal,positive_control_parent_LNA_gapmer_ALT_signal,parent fully PS LNA gapmer retains activity but raises ALT/body-weight toxicity signal,Focused v1.0 benchmark/control for challenge-aligned source-specific demonstration.,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_BROTHERS_ASO_PNA_ALT_MITIGATION,negative_control_BROTHERS_ASO_PNA_toxicity_mitigation,negative_control_BROTHERS_ASO_PNA_toxicity_mitigation,BRO duplex retains knockdown while reducing protein/off-target interactions and ALT elevation,Focused v1.0 benchmark/control for challenge-aligned source-specific demonstration.,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_APOC3_GALNAC_SIRNA_LONG_ACTING_SAFE,negative_control_APOC3_long_acting_GalNAc_siRNA,negative_control_APOC3_long_acting_GalNAc_siRNA,durable APOC3 lowering with favorable selectivity and tolerability,Focused v1.0 benchmark/control for challenge-aligned source-specific demonstration.,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_GALNAC_SIRNA_LCMS_BIOANALYSIS,context_control_GalNAc_siRNA_LCMS_bioanalysis,context_control_GalNAc_siRNA_LCMS_bioanalysis,LC/MS quantification module for parent/metabolite PK and reproducibility,Focused v1.0 benchmark/control for challenge-aligned source-specific demonstration.,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_ORAL_MIR29A_FIBROSIS_NA,context_control_oral_miR29a_like_liver_fibrosis_NA,context_control_oral_miR29a_like_liver_fibrosis_NA,modified nuclease-resistant oral NA suppresses fibrosis markers in CCl4 liver-injury context,Focused v1.0 benchmark/control for challenge-aligned source-specific demonstration.,UMEZU_ORAL_MIR29A_LIVER_FIBROSIS_NA_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_LNP_CRISPR_HAO1_NO_LIVER_TOX_LONG_TERM,negative_control_LNP_CRISPR_HAO1_long_term_liver_safety,negative_control_LNP_CRISPR_HAO1_long_term_liver_safety,"single-dose LNP-CRISPR HAO1/Hao1 context shows durable effect with low off-target, liver-toxicity, and immune-response signals",Focused v1.0 control for challenge-aligned source-specific demonstration.,JIANG_LNP_CRISPR_HAO1_PH1_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_PS_LNA_ASO_INTERNALIZATION_LOW_TOX,context_control_PS_LNA_ASO_internalization_tolerability,context_control_PS_LNA_ASO_internalization_tolerability,"vehicle-free PS/LNA ASO context with cell-uptake, viability, and cytoplasmic internalization measurements",Focused v1.0 control for challenge-aligned source-specific demonstration.,GOTFRID_PS_LNA_HIV_ASO_ACTIVITY_2026,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_ESCPLUS_SEED_DESTABILIZED_LOW_ALT,negative_control_ESCplus_seed_pairing_destabilized_GalNAc_siRNA_low_ALT,negative_control_ESCplus_seed_pairing_destabilized_GalNAc_siRNA_low_ALT,single GNA or 2-5-RNA seed-region destabilization reduces seed-mediated off-target interaction while preserving on-target activity and lowering ALT liability,Focused v1.0 control for challenge-aligned source-specific demonstration.,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_ESC_PARENT_SEED_OFFTARGET_ALT,positive_control_parent_ESC_GalNAc_siRNA_seed_offtarget_ALT,positive_control_parent_ESC_GalNAc_siRNA_seed_offtarget_ALT,parent ESC GalNAc-siRNA context with seed-mediated off-target hepatotoxicity and ALT elevation risk,Focused v1.0 control for challenge-aligned source-specific demonstration.,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_LNA_PTTE_BACKBONE_ACTIVITY,context_control_LNA_phosphothiotriester_backbone_activity,context_control_LNA_phosphothiotriester_backbone_activity,charge-neutral LNA-phosphothiotriester SSO chemistry with duplex stability and splice-switching activity context,Focused v1.0 control for challenge-aligned source-specific demonstration.,DHARA_LNA_PHOSPHOTHIOTRIESTER_SSO_CLICK_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_FXR_G0S2_DILI_RESCUE,context_control_FXR_G0S2_metabolic_DILI_rescue,context_control_FXR_G0S2_metabolic_DILI_rescue,FXR/JNK/G0s2 hepatotoxicity pathway context where pathway modulation reduces liver-injury and metabolic-disorder signals,Focused v1.0 control for challenge-aligned source-specific demonstration.,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_POS_HIGH_AFFINITY_GAPMER_RNASEH1_LONG_PREMRNA_ALT,positive_control_high_affinity_gapmer_RNaseH1_very_long_pre_mRNA_ALT,positive_control_high_affinity_gapmer_RNaseH1_very_long_pre_mRNA_ALT,high-affinity LNA/cEt-like gapmer context with promiscuous RNase H1-dependent reduction of very long pre-mRNAs and ALT/AST liability,Focused v1.0 control for challenge-aligned source-specific demonstration.,BUREL_GAPMER_RNASEH1_LONG_PREMRNA_HEPATOTOX_2016,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_NEG_MOE_OR_RNASEH1_ATTENUATED_GAPMER,negative_control_MOE_or_RNaseH1_attenuated_gapmer_low_ALT,negative_control_MOE_or_RNaseH1_attenuated_gapmer_low_ALT,MOE-like or RNase-H1-attenuated context with lower very-long-pre-mRNA off-target reduction and lower transaminase liability,Focused v1.0 control for challenge-aligned source-specific demonstration.,BUREL_GAPMER_RNASEH1_LONG_PREMRNA_HEPATOTOX_2016,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_QC_FREE_ASO_PAYLOAD_LCMS_SPECIFICITY,measurement_control_free_ASO_payload_LCMS_specificity,measurement_control_free_ASO_payload_LCMS_specificity,"hybridization LC-MS/MS context separating free ASO payload from intact conjugate, linker-bearing ASO, and metabolites",Focused v1.0 control for challenge-aligned source-specific demonstration.,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,
+CTRL_CONTEXT_PUM1_EXOSOME_HSC_FIBROSIS_AXIS,context_control_PUM1_exosome_HSC_fibrosis_axis,context_control_PUM1_exosome_HSC_fibrosis_axis,PUM1-enriched hepatocyte exosome context suppressing TPM4 translation and HSC activation; PUM1 loss aggravates MASLD liver injury,Focused v1.0 control for challenge-aligned source-specific demonstration.,WAN_PUM1_EXOSOMES_MASLD_HSC_FIBROSIS_2025,inferred_from_paper,dbbun_generated,CC BY 4.0,,,,,,

data_dictionary.csv

@@ -0,0 +1,381 @@
+allowed_values_or_range,column_name,data_type,description,field_name,origin_rule,provenance,provenance_expectation,required,table_name,type,value_origin
+,source_id,string_or_numeric,Unique source identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
+,title,string_or_numeric,Source paper or memo title.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
+,source_role,string_or_numeric,How the source contributes to generation logic.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
+,use_in_core_dataset,string_or_numeric,"Whether source is core, supporting, or governing.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
+,control_id,string_or_numeric,Unique control identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
+,control_type,string_or_numeric,"Negative, positive, vehicle/mock, clinical reference, or stress-test control type.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
+,control_rationale,string_or_numeric,Why this control is included.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
+,expected_behavior,string_or_numeric,Expected synthetic readout behavior.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
+,oligo_id,string_or_numeric,Unique generated oligonucleotide identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
+,sequence_5to3,string_or_numeric,Generated RNA sequence in 5 to 3 orientation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
+,oligo_modality,string_or_numeric,"ASO, gapmer, siRNA, GalNAc-siRNA, or related modality.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
+,control_id,string_or_numeric,"Control link, or NON_CONTROL_GENERATED_RECORD.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
+,sugar_chemistry,string_or_numeric,Generated/inferred sugar chemistry class.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
+,phosphorothioate_fraction,string_or_numeric,Generated fraction of possible backbone linkages represented as PS.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
+,GalNAc_conjugated,string_or_numeric,"1 if GalNAc conjugation is present, else 0.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
+,purity,string_or_numeric,Generated or inferred oligo purity value.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
+,GC_content,string_or_numeric,Sequence GC fraction.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
+,seed_region_GC,string_or_numeric,GC fraction in seed-like region.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
+,predicted_offtarget_hybridization_burden,string_or_numeric,"Synthetic off-target burden score, 0-10.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
+,predicted_Tm_celsius,string_or_numeric,Generated melting temperature proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
+,predicted_delta_G_kcal_mol,string_or_numeric,Generated hybridization free energy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
+,dose_nM,string_or_numeric,Generated or inferred concentration in nM.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
+,dose_tier,string_or_numeric,Categorical dose tier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
+,exposure_duration_days,string_or_numeric,Generated exposure duration.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
+,relative_exposure_normalization,string_or_numeric,Dose normalized to 150 nM reference.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
+,delivery_carrier_type,string_or_numeric,Generated delivery system or nanocarrier type.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,delivery_carrier_class,string_or_numeric,"Lipid-based, polymeric, metallic/inorganic, biomimetic, direct conjugate, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,nanoparticle_size_nm,string_or_numeric,Generated particle size in nanometers; zero for direct conjugate or no carrier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,zeta_potential_mV,string_or_numeric,Generated surface charge proxy in millivolts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,pegylated,string_or_numeric,1 if PEGylation or stealth-like coating is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,targeting_ligand,string_or_numeric,"Generated active targeting ligand such as GalNAc, galactose, mannose, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,targeting_receptor,string_or_numeric,"Generated receptor context such as ASGPR, NTCP, mannose receptor, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,hepatic_targeting_score,string_or_numeric,Generated 0-1 liver-targeting score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,kupffer_clearance_risk,string_or_numeric,Generated 0-1 Kupffer/RES clearance risk.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,delivery_immunogenicity_score,string_or_numeric,Generated 0-1 delivery-related immunogenicity score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,delivery_oxidative_stress_score,string_or_numeric,Generated 0-1 delivery-related oxidative stress score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
+,rna_payload_type,string_or_numeric,"Generated RNA payload architecture such as single siRNA, single ASO, mRNA vaccine, or dual siRNA+mRNA.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,siRNA_payload_fraction,string_or_numeric,Generated fraction of RNA payload represented as siRNA.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,mRNA_payload_fraction,string_or_numeric,Generated fraction of RNA payload represented as mRNA.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,pcsk9_knockdown_pct_proxy,string_or_numeric,Generated proxy for PCSK9 knockdown percentage when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,MHC_I_upregulation_fold_proxy,string_or_numeric,Generated proxy for MHC-I upregulation fold-change when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,antigen_presentation_fold_proxy,string_or_numeric,Generated proxy for antigen-presentation enhancement when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,immune_activation_score,string_or_numeric,"Generated 0-1 immune-activation context score, separated from direct hepatotoxicity readouts.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,inflammatory_context_score,string_or_numeric,Generated 0-1 inflammatory context score for stress-testing readout logic.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
+,lipid_export_state,string_or_numeric,"Generated lipid-export context such as baseline, APOB-ASO inhibition, oleate challenge, heat-stress challenge, or combined lipid stress.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,mipomersen_like_APOB_ASO,string_or_numeric,Indicator that the row represents a Mipomersen-like APOB ASO context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,apob_inhibition_proxy,string_or_numeric,Generated proxy for APOB suppression; not a measured value.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,mttp_activity_suppression_proxy,string_or_numeric,Generated proxy for MTTP activity suppression in lipid-export context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,vldl_apob_secretion_proxy,string_or_numeric,Generated proxy for VLDL-ApoB secretion capacity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,lipid_export_stress_score,string_or_numeric,Generated lipid-homeostasis stress score kept separate from direct hepatotoxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
+,epigenetic_liver_state,string_or_numeric,"Generated MASLD epigenetic/lipid state such as baseline, H3K27ac-high, SULT1B1-siRNA rescue, CEBPB-siRNA rescue, JQ1-like SE inhibition, or oleate-induced lipid accumulation.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,h3k27ac_super_enhancer_activity_proxy,string_or_numeric,Generated proxy for H3K27ac/super-enhancer activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,cebp_beta_activity_proxy,string_or_numeric,Generated proxy for C/EBPbeta activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,sult1b1_expression_proxy,string_or_numeric,Generated proxy for SULT1B1 expression/activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,hepatocyte_lipid_accumulation_proxy,string_or_numeric,Generated proxy for hepatocyte lipid accumulation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,epigenetic_liver_stress_modifier,string_or_numeric,Generated modifier used to stress-test hepatotoxicity scoring under MASLD-like liver context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
+,angptl3_platform_context,string_or_numeric,"Generated ANGPTL3 platform context: GalNAc-ASO/vupanorsen-like, GalNAc-siRNA/ARO-ANG3-like, mAb reference, or non-ANGPTL3.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,angptl3_target_inhibition_pct_proxy,string_or_numeric,Generated proxy for ANGPTL3 target inhibition percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,angptl3_hepatic_fat_change_pct_proxy,string_or_numeric,Generated proxy for percent hepatic-fat change relative to baseline.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,angptl3_alt_ast_gt3x_uln_probability_proxy,string_or_numeric,Generated probability proxy for ALT/AST greater than 3x ULN.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,angptl3_transaminase_signal_fold_ULN_proxy,string_or_numeric,Generated transaminase signal proxy in fold upper limit of normal.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,angptl3_liver_safety_stress_modifier,string_or_numeric,Generated stress modifier used to stress-test ANGPTL3 platform liver-safety context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
+,pnpla3_genotype,string_or_numeric,"Generated PNPLA3 genotype context: wildtype, heterozygous, or I148M homozygous.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,pnpla3_lipid_droplet_accumulation_proxy,string_or_numeric,Generated proxy for PNPLA3-associated lipid-droplet accumulation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,pnpla3_precision_therapy_modality,string_or_numeric,"Generated PNPLA3-targeted precision therapy context: none, siRNA, or ASO.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,pnpla3_target_knockdown_pct_proxy,string_or_numeric,Generated proxy for PNPLA3 knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,pnpla3_hepatic_fat_reduction_pct_proxy,string_or_numeric,Generated proxy for hepatic-fat reduction under PNPLA3 silencing context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,pnpla3_therapy_response_label,string_or_numeric,"Generated label describing homozygous response, heterozygous uncertainty, or baseline context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
+,extrahepatic_delivery_state,string_or_numeric,"Generated extrahepatic delivery state, including cholesterol-conjugated siRNA muscle-delivery contexts.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,extrahepatic_conjugate_type,string_or_numeric,"Generated conjugate type such as cholesterol conjugate, GalNAc conjugate, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,extrahepatic_administration_route,string_or_numeric,"Generated route such as intraperitoneal, intravenous, in vitro transfection, or gymnosis.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,systemic_dose_mg_per_kg_proxy,string_or_numeric,Generated systemic dose proxy in mg/kg for animal delivery contexts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,skeletal_muscle_knockdown_pct_proxy,string_or_numeric,Generated proxy for skeletal-muscle target mRNA knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,diaphragm_knockdown_pct_proxy,string_or_numeric,Generated proxy for diaphragm knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,liver_knockdown_pct_proxy,string_or_numeric,"Generated proxy for liver target mRNA knockdown percentage, used as exposure/distribution context rather than injury evidence.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,liver_marker_signal_fold_proxy,string_or_numeric,Generated liver-marker signal proxy; values near 1 imply no major signal.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,extrahepatic_delivery_confidence_score,string_or_numeric,Generated confidence score for extrahepatic delivery/distribution context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
+,personalized_aso_state,string_or_numeric,"Generated patient-customized ASO workflow state, such as design, fibroblast screen, intrathecal dosing, toxicology, or N-of-1 monitoring.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,customized_to_patient_variant,string_or_numeric,1 when the record is modeled as patient-specific variant-informed ASO design context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,splice_modulating_strategy,string_or_numeric,Generated splice-modulation strategy such as cryptic splice acceptor blocking.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,aso_backbone_chemistry,string_or_numeric,"Generated ASO backbone chemistry context, e.g., phosphorothioate.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,aso_sugar_chemistry,string_or_numeric,"Generated sugar chemistry context, e.g., 2prime-MOE.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,sequence_specific_offtarget_screen_pass,string_or_numeric,Generated binary proxy indicating whether the sequence passed a basic off-target screen.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,fibroblast_splice_rescue_fold_proxy,string_or_numeric,Generated proxy for in vitro splice rescue fold change.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,rat_toxicology_dose_multiple_proxy,string_or_numeric,Generated preclinical toxicology dose multiple context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,human_dose_mg_proxy,string_or_numeric,"Generated human intrathecal dose context in mg, when applicable.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,csf_trough_ng_per_ml_proxy,string_or_numeric,Generated CSF trough concentration context for intrathecal dosing records.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,personalized_workflow_confidence_score,string_or_numeric,Generated confidence score for the ASO workflow context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
+,aso_metabolic_nafld_state,string_or_numeric,"Generated ASO metabolic/NAFLD context such as GalNAc-targeted benefit, native ASO broad distribution, lipid/DNL target ASO, sequence-motif toxicity, type-I IFN response, or kidney monitoring context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_metabolic_target_class,string_or_numeric,"Generated target class such as DNL/lipid partitioning, immune/adipose context, or general ASO metabolic context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_RNase_H1_gapmer_context,string_or_numeric,1 when an RNase-H1/gapmer-like ASO mechanism is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_GalNAc_hepatocyte_targeting_multiplier_proxy,string_or_numeric,Generated GalNAc hepatocyte-targeting potency multiplier proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_predicted_steatosis_change_proxy,string_or_numeric,Generated proxy for steatosis change; negative values indicate modeled improvement.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_insulin_sensitivity_improvement_proxy,string_or_numeric,Generated proxy for insulin-sensitivity improvement under metabolic ASO contexts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_DNL_pathway_suppression_proxy,string_or_numeric,Generated proxy for de novo lipogenesis or lipid-partitioning pathway suppression.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_metabolic_benefit_score,string_or_numeric,Generated 0-1 metabolic benefit score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_hepatic_injury_challenge_score,string_or_numeric,Generated 0-1 hepatic injury/safety-challenge score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_ALT_AST_monitoring_fold_proxy,string_or_numeric,Generated ALT/AST monitoring fold-change proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_GGT_monitoring_fold_proxy,string_or_numeric,Generated GGT monitoring fold-change proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_sequence_motif_toxicity_context,string_or_numeric,"Generated sequence-motif toxicity context, including TGC/TCC-like motif flags when relevant.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_type_I_interferon_response_proxy,string_or_numeric,Generated type-I-interferon off-target response proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_kidney_injury_monitoring_proxy,string_or_numeric,Generated kidney-injury monitoring proxy for ASO safety context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,aso_metabolic_safety_label,string_or_numeric,Generated label summarizing ASO metabolic benefit versus safety challenge.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
+,assay_id,string_or_numeric,Unique generated assay identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
+,cell_model,string_or_numeric,Liver-relevant model system.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
+,human_in_vitro_or_clinical_proxy,string_or_numeric,1 for human-relevant in vitro or clinical proxy models.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
+,time_hours,string_or_numeric,Assay readout timepoint.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
+,viability_pct,string_or_numeric,Generated viability percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,ALT_AST_proxy_fold_change,string_or_numeric,Generated ALT/AST-like liver injury proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,apoptosis_score,string_or_numeric,Generated apoptosis score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,stress_response_score,string_or_numeric,Generated stress signaling score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,transcriptomic_perturbation_score,string_or_numeric,Generated transcriptomic perturbation score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,immune_activation_score,string_or_numeric,"Generated immune-activation context score, separated from direct hepatotoxicity measurement.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,inflammatory_context_score,string_or_numeric,Generated inflammatory-context score used to stress-test readout generation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,overall_hepatotoxicity_risk_score,string_or_numeric,"Composite time-adjusted synthetic risk score, 0-10.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,hepatotoxicity_label,string_or_numeric,"low, moderate, or high.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
+,generated_record_id,string_or_numeric,Unified generated record identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
+,record_type,string_or_numeric,oligo_level_record or toxicity_readout_record.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
+,measured_experimental_value,string_or_numeric,Always no unless later manually upgraded.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
+,assumption_id,string_or_numeric,Unique assumption identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assumptions.csv,,
+,assumption_text,string_or_numeric,Human-readable assumption statement.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assumptions.csv,,
+,provenance_id,string_or_numeric,Unique provenance row identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,provenance.csv,,
+,source_pdf_redistributed,string_or_numeric,No; source PDFs are not included in generated output.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,provenance.csv,,
+,sequence_modification_toxicity_state,string_or_numeric,"Generated sequence/modification toxicity state, including LNA/PS gapmer low-risk, high-risk, redesign, or applicability-domain context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,lna_gapmer_context,string_or_numeric,1 when the record is modeled as an LNA/gapmer-style sequence-toxicity context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,phosphorothioate_full_backbone_context,string_or_numeric,1 when high/full PS-backbone context is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,dinucleotide_feature_encoding,string_or_numeric,"Generated descriptor of the sequence encoding concept, such as 64-dinucleotide count vector context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,toxic_gap_motif_count_proxy,string_or_numeric,Generated count of higher-risk motif proxies in the DNA-like sequence representation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,protective_or_lower_risk_motif_count_proxy,string_or_numeric,Generated count of lower-risk/protective motif proxies in the DNA-like sequence representation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,model_family,string_or_numeric,"Generated model-family label, such as random-forest-style dinucleotide classifier context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,training_set_oligo_count_proxy,string_or_numeric,Source-informed training-set size proxy used for context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,oob_accuracy_proxy,string_or_numeric,Source-informed out-of-bag accuracy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,validation_accuracy_proxy,string_or_numeric,Source-informed independent validation accuracy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,predicted_sequence_hepatotoxicity_probability_proxy,string_or_numeric,Generated probability-like proxy for sequence/modification hepatotoxicity potential.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,predicted_ALT_fold_from_sequence_model_proxy,string_or_numeric,Generated ALT fold proxy derived from sequence/modification risk context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,predicted_sequence_toxicity_class,string_or_numeric,Generated low/high/not-modeled sequence-toxicity class.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,nearest_training_edit_distance_proxy,string_or_numeric,Generated edit-distance/applicability-domain proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,prediction_confidence_by_distance_label,string_or_numeric,Generated confidence label based on near/medium/far distance context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,redesign_to_lower_toxicity_applicable,string_or_numeric,1 when a sequence redesign-to-lower-toxicity concept is applicable.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,sequence_redesign_risk_reduction_proxy,string_or_numeric,Generated risk-reduction proxy for redesigned sequence context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,sequence_modification_toxicity_modifier,string_or_numeric,Generated risk-score modifier from sequence/modification toxicity profile.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
+,hsd17b13_clinical_state,string_or_numeric,Generated HSD17B13/rapirosiran clinical context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_like_dose_mg_proxy,string_or_numeric,Generated rapirosiran-like clinical dose proxy in mg.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_HSD17B13_mRNA_change_month6_pct_proxy,string_or_numeric,Generated percentage-change proxy for liver HSD17B13 mRNA at Month 6.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_ALT_change_day169_pct_proxy,string_or_numeric,Generated ALT percentage-change proxy around Day 169/Month 6 clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_AST_change_day169_pct_proxy,string_or_numeric,Generated AST percentage-change proxy around Day 169/Month 6 clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_no_DILI_observed_flag,string_or_numeric,Generated flag representing no drug-induced liver injury context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_ASGPR_saturation_context,string_or_numeric,Generated ASGPR/GalNAc uptake and transient saturation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_clinical_safety_modifier,string_or_numeric,Generated risk-score safety modifier from rapirosiran clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,rapirosiran_clinical_benefit_modifier,string_or_numeric,Generated benefit/PD modifier from HSD17B13 knockdown and clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
+,hbv_rnai_state,string_or_numeric,Generated VIR-2218/ALN-HBV ESC+ HBV RNAi context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_ESCplus_seed_modification,string_or_numeric,Generated flag for ESC+ seed-region modification context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_gna_seed_substitution,string_or_numeric,Generated flag for glycol nucleic acid seed-region substitution context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_seed_mediated_offtarget_reduction_score,string_or_numeric,Generated score representing reduced seed-mediated off-target binding context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_predicted_offtarget_gene_dysregulation_score,string_or_numeric,Generated off-target gene-dysregulation proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_healthy_volunteer_ALT_elevation_pct_proxy,string_or_numeric,Generated percentage proxy for healthy-volunteer ALT-elevation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_highest_ALT_xULN_proxy,string_or_numeric,Generated highest ALT relative to upper limit of normal proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_HBsAg_reduction_week20_log10_proxy,string_or_numeric,Generated Week-20 HBsAg log10 reduction proxy for cHBV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_HBsAg_reduction_week48_log10_proxy,string_or_numeric,Generated Week-48 HBsAg log10 reduction proxy for cHBV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_safety_modifier,string_or_numeric,Generated modifier linking seed/off-target/ALT context to synthetic hepatotoxicity score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,hbv_rnai_antiviral_activity_score,string_or_numeric,Generated antiviral PD context score based on HBsAg reduction proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
+,zilebesiran_state,string_or_numeric,Generated zilebesiran/AGT GalNAc-siRNA RAAS context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_target_mRNA,string_or_numeric,Target mRNA context for angiotensinogen/AGT silencing.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_GalNAc_ASGPR_hepatocyte_delivery_flag,string_or_numeric,Flag for GalNAc-ASGPR hepatocyte-targeted delivery context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_endosomal_depot_context_flag,string_or_numeric,Flag for prolonged endosomal-depot context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_RISC_recycling_context_flag,string_or_numeric,Flag for RISC-recycling and repeated target mRNA degradation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_single_dose_mg_proxy,string_or_numeric,Generated fixed-dose mg proxy for zilebesiran-like clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_serum_AGT_reduction_pct_proxy,string_or_numeric,Generated serum angiotensinogen reduction percentage proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_systolic_BP_reduction_mmHg_proxy,string_or_numeric,Generated systolic blood-pressure reduction proxy in mmHg.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_hyperkalemia_pct_proxy,string_or_numeric,Generated hyperkalemia event percentage proxy for systemic RAAS safety monitoring.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_hypotension_pct_proxy,string_or_numeric,Generated hypotension event percentage proxy for systemic RAAS safety monitoring.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_eGFR_decline_event_pct_proxy,string_or_numeric,Generated eGFR-decline/renal-function monitoring event proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_hypovolemia_rescue_context,string_or_numeric,Generated context label for reversibility/rescue strategies when RAAS is suppressed.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,zilebesiran_direct_hepatotoxicity_modifier,string_or_numeric,Generated modifier showing that this source contributes little direct hepatotoxicity signal while tracking systemic safety separately.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
+,sirna_bulge_state,string_or_numeric,Generated siRNA bulge-context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,guide_strand_bulge_mode,string_or_numeric,Guide-passenger or guide-target/degenerate target bulge mode.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,bulge_length_nt_proxy,string_or_numeric,Generated bulge length proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,bulge_position_guide_nt_proxy,string_or_numeric,Generated guide-strand position proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,bulge_region_label,string_or_numeric,"Seed, central, terminal, or reference region label.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,offtarget_prediction_include_deletions_flag,string_or_numeric,Flag indicating off-target prediction should consider nucleotide omissions/deletions that create tolerated bulges.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,bulge_related_offtarget_risk_modifier,string_or_numeric,Generated off-target-risk modifier from tolerated/degenerated bulge context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
+,fbll1_hcc_state,string_or_numeric,Generated FBLL1/HCC spatial-oncogenic context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_malignant_hepatocyte_enrichment_score,string_or_numeric,Generated proxy for FBLL1 enrichment in malignant hepatocytes / tumor regions.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_siRNA_knockdown_context_flag,string_or_numeric,Flag for FBLL1 siRNA knockdown functional experiment context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_knockdown_proliferation_suppression_proxy,string_or_numeric,Generated proxy for proliferation suppression after FBLL1 knockdown.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_overexpression_tumorigenesis_proxy,string_or_numeric,Generated proxy for tumorigenesis/colony/migration context after FBLL1 overexpression.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_EGFR_MAPK_activation_score_proxy,string_or_numeric,Generated proxy for c-Myc/EGFR-ligand/MAPK activation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,fbll1_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier clarifying that this source is mostly HCC/RNAi functional context rather than direct oligonucleotide hepatotoxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
+,galnac_lnp_mkk4_state,string_or_numeric,Generated GalNAc-LNP-siMKK4 hepatocyte-targeted liver-regeneration context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_dual_targeting_context,string_or_numeric,LNP liver tropism plus GalNAc/ASGPR hepatocyte active-targeting context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_target_selectivity_mkk7_avoidance_score,string_or_numeric,Generated proxy for MKK4-selective siRNA design relative to MKK7 off-target concern.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_particle_size_nm_proxy,string_or_numeric,Generated particle-size proxy based on GalNAc-LNP-siMKK4 characterization.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_encapsulation_efficiency_pct_proxy,string_or_numeric,Generated encapsulation-efficiency proxy for GalNAc-LNP-siMKK4.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_hepatocyte_targeting_score,string_or_numeric,Generated ASGPR/HNF-4a hepatocyte-targeting proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_mkk4_knockdown_score,string_or_numeric,Generated proxy for MKK4 silencing strength.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_liver_regeneration_score_proxy,string_or_numeric,Generated proxy for liver-regeneration/proliferation rescue.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,mkk4_lnp_direct_hepatotoxicity_modifier,string_or_numeric,Modifier separating background injury model from direct oligo/LNP hepatotoxicity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
+,ogt_sev_lsec_state,string_or_numeric,"Generated state for OGT-enriched hepatocyte-derived sEV, LSEC capillarization, OGT knockdown, BAGN rescue, or healthy-sEV reference context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_ogt_cargo_score_proxy,string_or_numeric,Generated proxy for OGT cargo enrichment in hepatocyte-derived or serum sEVs.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_HNF1A_ser471_OGlcNAcylation_score_proxy,string_or_numeric,Generated proxy for HNF1A Ser471 O-GlcNAcylation linked to Ang-2 transcriptional activation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_Ang2_transcription_activation_score_proxy,string_or_numeric,Generated proxy for Ang-2 transcription/expression activation downstream of HNF1A.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_LSEC_capillarization_score_proxy,string_or_numeric,Generated proxy for LSEC capillarization/angiogenesis/defenestration context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_ALT_AST_correlation_context_score_proxy,string_or_numeric,Generated proxy for MASLD serum ALT/AST association with OGT/sEV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_BAGN_rescue_score_proxy,string_or_numeric,Generated proxy for BAGN-mediated O-GlcNAc inhibition and MASLD/LSEC rescue.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_masld_progression_modifier,string_or_numeric,Modifier representing MASLD microenvironment stress from OGT/sEV/LSEC capillarization context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,ogt_sev_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox liver context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
+,malat1_hbv_hcc_state,string_or_numeric,"Generated state for HBx-induced MALAT1, m6A/IGF2BP3 shuttling, ASO-MALAT1 rescue, HBV replication context, or non-modeled reference.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_expression_score_proxy,string_or_numeric,Generated proxy for MALAT1 expression in HBV/HBx-related HCC context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_m6a_score_proxy,string_or_numeric,Generated proxy for MALAT1 m6A modification level.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_mettl3_mettl14_wtap_recruitment_score_proxy,string_or_numeric,Generated proxy for MALAT1 recruitment of m6A writer complex METTL3/METTL14/WTAP.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_m6a_site_6021A_score_proxy,string_or_numeric,Generated proxy for contribution of MALAT1 6021A m6A site.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_m6a_site_7265A_score_proxy,string_or_numeric,Generated proxy for contribution of MALAT1 7265A m6A site.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_igf2bp3_binding_score_proxy,string_or_numeric,Generated proxy for m6A-dependent MALAT1 binding by IGF2BP3.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_cytoplasmic_export_score_proxy,string_or_numeric,Generated proxy for IGF2BP3-associated MALAT1 nuclear-cytoplasmic shuttling.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_aso_tumor_suppression_score_proxy,string_or_numeric,Generated proxy for ASO-MALAT1 suppression of HBV-related HCC tumor growth/spread.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_hbv_pgRNA_reduction_proxy,string_or_numeric,Generated proxy for reduction in HBV pgRNA context following ASO-MALAT1 treatment.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_hepatocarcinogenesis_context_modifier,string_or_numeric,Modifier representing HBV/HBx/MALAT1 liver-cancer context severity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,malat1_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox through ASO liver intervention and liver disease context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
+,cd133_masld_hcc_state,string_or_numeric,"Generated state for CD133-positive MASLD-HCC cancer stem cell enrichment, MYH9/beta-catenin mechanism, multikinase-inhibitor resistance, or VNP-siCD133 rescue.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_csc_enrichment_score_proxy,string_or_numeric,Generated proxy for enrichment of CD133-positive cancer stem cell context in MASLD-HCC.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_lineage_expansion_score_proxy,string_or_numeric,Generated proxy for CD133 lineage expansion/clonal amplification context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_self_renewal_score_proxy,string_or_numeric,Generated proxy for organoid/self-renewal stemness context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_tumor_initiating_capacity_proxy,string_or_numeric,Generated proxy for tumor-initiating capacity in MASLD-HCC models.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_mki_resistance_score_proxy,string_or_numeric,Generated proxy for resistance to multikinase inhibitors such as sorafenib or lenvatinib.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_myh9_interaction_score_proxy,string_or_numeric,Generated proxy for CD133-MYH9 physical/mechanistic interaction context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_wnt_bcat_activation_score_proxy,string_or_numeric,Generated proxy for Wnt/active-beta-catenin pathway activation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_vnp_sicd133_delivery_context_flag,string_or_numeric,Flag indicating VNP-siCD133 nanoparticle delivery context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_2prime_ome_pyrimidine_modification_flag,string_or_numeric,Flag indicating stabilizing 2-prime-O-methyl pyrimidine-modified siRNA context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_tumor_weight_reduction_score_proxy,string_or_numeric,Generated proxy for tumor-weight/burden reduction after VNP-siCD133 plus multikinase inhibitor context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_masld_hcc_therapeutic_rescue_score_proxy,string_or_numeric,Composite generated proxy for therapeutic rescue after CD133-targeted siRNA combination therapy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,cd133_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox through siRNA liver intervention and liver-disease context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
+,galnac_rbc_ev_state,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_asgpr_hepatocyte_uptake_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_payload_type,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_mir155_knockdown_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_rab7_knockdown_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_parp1_par_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_alf_alt_ast_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_panoptosis_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_nafld_steatosis_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_hcc_tumor_suppression_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,rbc_ev_vital_organ_toxicity_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
+,meldplus_cirrhosis_state,string_or_numeric,Generated MELD-Plus/cirrhosis clinical risk context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_variable_count_proxy,string_or_numeric,Number of structured clinical variables represented in the MELD-Plus model context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_albumin_g_dl_proxy,string_or_numeric,Generated proxy for albumin value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_total_bilirubin_mg_dl_proxy,string_or_numeric,Generated proxy for total bilirubin value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_creatinine_mg_dl_proxy,string_or_numeric,Generated proxy for creatinine value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_inr_proxy,string_or_numeric,Generated proxy for INR value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_sodium_mmol_l_proxy,string_or_numeric,Generated proxy for sodium value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_wbc_th_cumm_proxy,string_or_numeric,Generated proxy for white blood cell count used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_total_cholesterol_mg_dl_proxy,string_or_numeric,Generated proxy for total cholesterol used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_predicted_90day_mortality_probability_proxy,string_or_numeric,Generated proxy for MELD-Plus-like 90-day post-discharge mortality probability.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_auroc_mgh_bwh_90day_proxy,string_or_numeric,Paper-reported AUROC context for MGH/BWH 90-day MELD-Plus model.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_auroc_external_validation_proxy,string_or_numeric,Paper-reported AUROC context for external validation cohort.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_clinical_severity_modifier,string_or_numeric,Generated clinical liver-severity modifier used to connect hepatotoxicity outputs to cirrhosis outcome-risk context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+,meldplus_direct_oligotox_relevance_modifier,string_or_numeric,"Small modifier indicating indirect clinical liver-risk relevance, not direct oligo intrinsic toxicity evidence.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
+0 or 1,,integer_flag,Flag indicating source is supporting preprint context rather than definitive peer-reviewed OligoTox evidence.,preprint_caution_flag,,,source_metadata,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
+0 to 1,,float,Generated proxy score summarizing ALT/AST safety-monitoring context for LNP-AGO1-ASO-like records.,ALT_AST_safety_monitoring_score_proxy,,,literature_grounded_generated,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
+0 to 1,,float,Generated proxy score for delivery and translational relevance of LNP-ASO context.,delivery_translatability_score_proxy,,,literature_grounded_generated,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
+controlled generated categories,,string,"Generated state label for GYS1 ASO Pompe substrate-reduction, combination therapy, tolerability, or specificity context.",gys1_pompe_state,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+2prime_constrained_ethyl_cEt,,string,Sugar modification context for the systemic GYS1 ASO module.,aso_sugar_modification,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
+3_10_3_cEt_gapmer,,string,Gapmer architecture used to represent the source ASO design.,gapmer_architecture,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
+0 to 1,,float,Generated proxy for Gys1 mRNA knockdown fraction in muscle-context records.,Gys1_mRNA_knockdown_fraction_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+0 to 1,,float,Generated proxy for specificity of GYS1 targeting versus liver GYS2 sparing.,GYS1_GYS2_isoform_specificity_score_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+0 to 1,,float,Generated proxy for muscle glycogen reduction fraction in the Pompe ASO substrate-reduction context.,quadriceps_glycogen_reduction_fraction_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+positive,,float,Generated proxy for ALT fold-change safety monitoring in systemic ASO treatment context.,ALT_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+positive,,float,Generated proxy for AST fold-change safety monitoring in systemic ASO treatment context.,AST_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+positive,,float,Generated proxy for kidney/safety chemistry monitoring context.,BUN_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+positive,,float,Generated proxy for muscle injury/safety chemistry monitoring context.,CK_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
+0 or 1,,integer_flag,Flag indicating source is supporting preprint context rather than definitive peer-reviewed OligoTox evidence.,preprint_caution_flag,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
+controlled generated categories,,string,"Generated state label for DDC cholestasis, recovery/resolution, CX3CL1-CX3CR1 macrophage recruitment, or NFYA/TGFB1 fibrosis context.",cholestasis_state,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+positive,,float,Generated ALT fold-change proxy for cholestatic hepatobiliary injury context.,ALT_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+positive,,float,Generated alkaline phosphatase fold-change proxy for cholestatic injury context.,ALP_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+positive,,float,Generated bilirubin fold-change proxy for cholestasis context.,bilirubin_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+positive,,float,Generated proxy for cholangiocyte CX3CL1 expression fold-change.,CX3CL1_expression_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+0 to 1,,float,Generated score for periportal CX3CR1-positive macrophage recruitment context.,CX3CR1_macrophage_recruitment_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+0 to 1,,float,Generated score for pathogen-induced cytokine storm signaling pathway activation in cholangiocytes.,PICSS_pathway_activation_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+0 to 1,,float,Generated score for NF-YA nuclear activation in cholangiocytes.,NFYA_nuclear_activation_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+0 to 1,,float,Generated score for cholangiocyte TGFβ1 expression/fibrogenic signaling context.,TGFB1_expression_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+0 or 1,,integer_flag,Flag for mechanistic siRNA NF-YA suppression reducing TGFβ1 expression in human cholangiocytes.,siRNA_NFYA_TGFB1_reduction_context_flag,,,source_metadata,yes,cholangiocyte_cholestasis_recovery_context.csv,,
+controlled generated categories,,string,"Generated state label for PCDHA11 AmNA-ASO target-specificity, off-target-screening, or sequence-dependent reversible liver-injury context.",pcdha11_amna_state,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 or 1,,integer_flag,Flag indicating generated AmNA-modified flanking nucleotide ASO context.,AmNA_modified_flanking_nucleotide_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 or 1,,integer_flag,Flag indicating generated fully phosphorothioated ASO backbone context.,all_phosphate_groups_phosphorothioated_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+"0.2, 0.6, 2.0 or generated nearby values",,float,"Generated mouse intraperitoneal dose proxy corresponding to the 0.2, 0.6, or 2.0 mg study structure.",mouse_intraperitoneal_dose_mg_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+positive,,float,Generated peak AST fold-change proxy for AmNA-ASO liver-enzyme response.,AST_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+positive,,float,Generated peak ALT fold-change proxy for AmNA-ASO liver-enzyme response.,ALT_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+positive,,float,Generated peak ALP fold-change proxy for AmNA-ASO liver-enzyme/cholestatic response.,ALP_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 to 1,,float,Generated score for recovery of liver-enzyme signals after treatment cessation.,recovery_after_treatment_cessation_score_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 to 1,,float,Generated score representing sequence-dependent liver-injury liability among PCDHA11 ASO candidates.,sequence_dependent_liver_injury_score_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+non-negative,,integer,Generated mismatch/off-target burden proxy based on the source paper's in silico and microarray screening structure.,offtarget_mismatch_burden_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 or 1,,integer_flag,Flag for target-specificity context comparing parental PCDHA11-expressing cells with PCDHA11-knockout cells.,PCDHA11_knockout_specificity_context_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
+0 to 1,,float,Generated score for PS-ASO nuclear PS-body/condensate formation under DNA-damage-response toxicity context.,PS_body_formation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
+0 to 1,,float,Generated score for ASO-associated DNA-PKcs binding/activation proxy.,DNA_PKcs_binding_activation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
+0 to 1,,float,Generated score for ASO-associated ATM binding/activation proxy.,ATM_binding_activation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
+0 to 1,,float,Generated score for ASO-associated PARP1 binding/PARylation proxy.,PARP1_binding_PARylation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
+0 to 1,,float,Composite generated proxy for PS-ASO DNA-damage-response toxicity mechanism.,overall_ASO_DDR_toxicity_mechanism_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
+0 to 1,,float,Generated score for oxidative-stress responsive nanocarrier shell disassembly in MASH context.,ROS_triggered_shell_disassembly_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
+0 to 1,,float,Generated score for GalNAc/ASGPR hepatocyte uptake context.,ASGPR_hepatocyte_uptake_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
+0 to 1,,float,Generated Rubicon knockdown score proxy for siRubicon records.,Rubicon_knockdown_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
+positive,,float,"Generated ALT proxy relative to MASH control context, where lower values indicate improved liver-function context.",ALT_relative_to_MASH_control_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
+0 to 1,,float,Composite generated proxy balancing delivery/lipophagy benefit against nanocarrier safety risk.,overall_delivery_benefit_minus_safety_risk_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
+0 to 1,,float,"Composite generated score balancing ASO knockdown, nuclease stability, and ALT/AST toxicity proxies.",activity_safety_window_score_proxy,,,,yes,scpBNA2_aso_chemistry_safety.csv,,literature_grounded_generated
+0 to 1,,float,Composite generated score for APAP liver-injury rescue context.,overall_APAP_AILI_rescue_score_proxy,,,,yes,siCyp2e1_lnp_apap_aili.csv,,literature_grounded_generated
+0 to 1,,float,Generated index balancing hepatocyte association against nonparenchymal-cell association.,hepatocyte_selectivity_index_proxy,,,,yes,lipid_nanp_liver_cell_targeting.csv,,literature_grounded_generated
+see table,,string_or_numeric,Generated score representing monitoring of non-target/off-target toxicity and dose-window evidence for self-assembling RNA nanoparticles.,offtarget_toxicity_monitoring_score_proxy,,,,yes,rna_nanoparticle_hcc_multitarget.csv,,literature_grounded_generated
+see table,,string_or_numeric,Generated score representing no-visible-toxicity/tolerability context for DCA-conjugated asymmetric siRNA.,visible_toxicity_absence_score_proxy,,,,yes,myc_asirna_dca_design_safety.csv,,literature_grounded_generated
+see table,,string_or_numeric,Generated score representing ligand/peptide-enabled intracellular delivery context for multifunctional HDOs.,intracellular_delivery_score_proxy,,,,yes,multifunctional_hdo_delivery.csv,,literature_grounded_generated
+see table,,string_or_numeric,Official Phase 2 judging criterion represented by dataset components.,judging_criterion,,,,yes,challenge_alignment_scorecard.csv,,literature_grounded_generated
+see table,,string_or_numeric,Public-domain information gap addressed by a source/module.,gap_addressed,,,,yes,information_gap_map.csv,,literature_grounded_generated
+see table,,string_or_numeric,Field/table role for predictive modeling or validation.,modeling_role,,,,yes,model_readiness_report.csv,,literature_grounded_generated
+see table,,string_or_numeric,"Decision to include, support, defer, or exclude a source.",triage_decision,,,,yes,source_triage_log.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,"Generated candidate class: screened, potent safe, toxicity-signal, or benchmark comparator.",candidate_class,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated RNAseq-style dose-dependent downregulated gene count proxy used as an off-target/toxicity indicator.,rnaseq_dose_dependent_downregulated_gene_count_proxy,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated safety-class label derived from ALT/AST/urea/histopathology/off-target proxies.,safety_class_generated,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated IRG1/ACOD1 expression proxy after CpG ODN/APAP/macrophage scenario simulation.,acod1_irg1_expression_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated itaconate pathway proxy linked to macrophage protection and oxidative-stress mitigation.,itaconate_metabolite_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated survival/improvement score for APAP injury scenarios.,survival_improvement_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated PET/PK organ Cmax proxy expressed as percent injected dose per gram.,cmax_percent_injected_dose_per_g_proxy,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated PET/PK AUC proxy for organ/tissue exposure across the dynamic acquisition window.,auc_0_5400_proxy,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Flag for organs relevant to renal/hepatobiliary exposure and oligo ADME context.,hepatobiliary_or_renal_burden_flag,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated score for ASO/PNA BRO toehold-mediated mismatch discrimination and RNA off-target reduction.,toehold_mismatch_discrimination_score_proxy,,,,no,brothers_aso_pna_toxicity_mitigation.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated efficacy-to-ALT safety-margin score for parent ASO versus BRO designs.,therapeutic_margin_score_proxy,,,,no,brothers_aso_pna_toxicity_mitigation.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated long-duration activity index for APOC3 GalNAc-siRNA scaffold scenarios.,duration_index_proxy,,,,no,apoc3_galnac_sirna_sar_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated rodent/NHP/cell tolerability proxy integrating off-target and ALT context.,tolerability_score_proxy,,,,no,apoc3_galnac_sirna_sar_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated lower-limit-of-quantification proxy for GalNAc-siRNA LC/MS bioanalysis.,lloq_ng_per_mL_proxy,,,,no,galnac_sirna_lcms_bioanalysis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated suitability score for deriving PK/TK parameters from siRNA bioanalysis workflow.,pk_parameter_suitability_score_proxy,,,,no,galnac_sirna_lcms_bioanalysis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated fibrosis-improvement score for oral modified miR-29a-like nucleic-acid therapy context.,fibrosis_improvement_score_proxy,,,,no,oral_mir29a_liver_fibrosis_na.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Delivery system context; this source emphasizes no-DDS oral modified nucleic-acid delivery.,delivery_system,,,,no,oral_mir29a_liver_fibrosis_na.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated liver-editing efficiency proxy for LNP-CRISPR-Cas9 HAO1/Hao1 PH1 context.,liver_editing_efficiency_fraction_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated off-target indel signal proxy for CRISPR delivery specificity context.,predicted_offtarget_indel_signal_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated liver toxicity signal proxy for long-term LNP-CRISPR safety context.,liver_toxicity_signal_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated cell-viability proxy for PS and PS/LNA modified ASO tolerability context.,cell_viability_fraction_proxy,,,,no,ps_lna_hiv_aso_internalization_toxicity.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated cytoplasmic internalization proxy for vehicle-free PS/LNA ASO uptake context.,cytoplasmic_internalization_score_proxy,,,,no,ps_lna_hiv_aso_internalization_toxicity.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated seed-mediated off-target binding proxy for ESC/ESC+ GalNAc-siRNA safety context.,seed_mediated_offtarget_binding_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated ALT elevation liability proxy for GalNAc-siRNA seed-offtarget hepatotoxicity context.,ALT_elevation_liability_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated therapeutic-window proxy integrating activity retention and ALT liability.,therapeutic_window_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated backbone-charge proxy for LNA-phosphothiotriester and comparator oligonucleotides.,estimated_backbone_charge_fraction_proxy,,,,no,lna_phosphothiotriester_splice_switching.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated splice-switching activity proxy for SSO chemistry context.,splice_switching_activity_proxy,,,,no,lna_phosphothiotriester_splice_switching.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated liver metabolic-hepatotoxicity proxy for FXR/JNK/G0s2 DILI context.,metabolic_hepatotoxicity_score_proxy,,,,no,fxr_jnk_g0s2_dili_context.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for RNase H1-dependent off-target reduction of very long pre-mRNA transcripts by high-affinity gapmer ASOs.,very_long_pre_mRNA_offtarget_reduction_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated transaminase-liability proxy for ASO chemistry/scenario context.,ALT_AST_liability_fold_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated inverse of broad off-target transcript reduction; higher means more selective.,transcriptome_selectivity_index_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated method-specificity proxy for hybridization LC-MS/MS free-ASO payload quantification.,method_specificity_score_proxy,,,,no,aoc_free_aso_payload_bioanalysis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated sample-preparation recovery proxy for free ASO payload measurement.,free_ASO_recovery_proxy,,,,no,aoc_free_aso_payload_bioanalysis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated HSC activation proxy for MASLD/fibrosis context.,HSC_activation_score_proxy,,,,no,pum1_exosome_masld_hsc_fibrosis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for PUM1-enriched exosome protection against HSC activation/lipotoxic injury.,PUM1_enriched_exosome_protection_proxy,,,,no,pum1_exosome_masld_hsc_fibrosis.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for early immune effector/apoptotic protein activation after bepirovirsen treatment.,immune_effector_activation_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for ALT association with liver/apoptosis-specific protein signals and responder biology.,ALT_increase_association_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for HBsAg decline/response context linked to bepirovirsen treatment.,HBsAg_decline_response_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for ASO stability/nuclease-resistance context associated with SNA modification.,nuclease_resistance_score_proxy,,,,no,sna_aso_kidney_systemic_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,"Generated proxy for liver damage/safety comparison among SNA, DNA, and MOE ASO contexts.",liver_damage_liability_score_proxy,,,,no,sna_aso_kidney_systemic_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for enhanced endosomal release of RNA payloads from polyamine-incorporated LNPs.,endosomal_escape_score_proxy,,,,no,polyamine_plnp_rna_delivery_safety.csv,,literature_grounded_generated
+,,generated_numeric_or_categorical,Generated proxy for liver-toxicity liability in LNP/p-LNP delivery scenarios.,liver_toxicity_liability_score_proxy,,,,no,polyamine_plnp_rna_delivery_safety.csv,,literature_grounded_generated
+0_to_1_proxy_or_categorical,,,Generated proxy for ASO off-target burden observed at RNA/transcriptome level.,rna_level_offtarget_burden_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for corresponding off-target signal observed at protein/proteomics level.,protein_level_offtarget_burden_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for RNA/protein mismatch indicating why proteomics can complement RNA-focused off-target assessment.,rna_protein_offtarget_discordance_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for ALT signal in GalNAc-siRNA preclinical safety scenarios.,ALT_signal_score_proxy,,literature_grounded_generated,,,sln360_galnac_sirna_preclinical_toxicology.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for known GalNAc-siRNA platform-related microscopic liver/kidney findings.,microscopic_platform_effect_score_proxy,,literature_grounded_generated,,,sln360_galnac_sirna_preclinical_toxicology.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for liver/Kupffer-cell targeting by biomimetic siRNA nanoparticles.,liver_or_Kupffer_targeting_score_proxy,,literature_grounded_generated,,,kupffer_biomimetic_sirna_srli.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for NLRP1/inflammasome/pyroptosis pathway activity in sepsis-related liver injury context.,pyroptosis_inflammasome_score_proxy,,literature_grounded_generated,,,kupffer_biomimetic_sirna_srli.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for ASO-induced EZH2 exon 14 skipping in liver/HCC contexts.,exon14_skipping_score_proxy,,literature_grounded_generated,,,ezh2_exon_skipping_hcc_aso.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for residual H3K27me3 epigenetic signal after EZH2 splice-switching ASO intervention.,H3K27me3_residual_score_proxy,,literature_grounded_generated,,,ezh2_exon_skipping_hcc_aso.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for extrahepatic DRG/sciatic nerve exposure after systemic HDO/ASO administration.,extrahepatic_distribution_score_proxy,,literature_grounded_generated,,,systemic_hdo_drg_sciatic_delivery.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for relative HDO delivery/potency improvement over parent single-stranded ASO.,potency_improvement_vs_parent_ASO_score_proxy,,literature_grounded_generated,,,systemic_hdo_drg_sciatic_delivery.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for ferroptosis induction or suppression in hepatic stellate cell/fibrosis contexts.,ferroptosis_score_proxy,,literature_grounded_generated,,,xist_hsc_ferroptosis_fibrosis.csv,float_or_string,
+0_to_1_proxy_or_categorical,,,Generated proxy for fibrosis-related hydroxyproline signal in mouse liver contexts.,hydroxyproline_HYP_fibrosis_score_proxy,,literature_grounded_generated,,,xist_hsc_ferroptosis_fibrosis.csv,float_or_string,
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing GalNAc-siRNA CIDEB target silencing in vitro/in vivo.,CIDEB_knockdown_score_proxy,,,,yes,galnac_sicidEB_mash_safety.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing steatosis/fibrosis benefit context in MASH models.,MASH_steatosis_or_fibrosis_benefit_score_proxy,,,,yes,galnac_sicidEB_mash_safety.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing late-onset CNS toxicity context for ASO chemistry scenarios.,late_onset_neurotoxicity_score_proxy,,,,yes,aso_late_onset_neurotox_chemical_modifications.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing preservation of target knockdown despite toxicity-mitigating chemistry.,target_knockdown_preservation_score_proxy,,,,yes,aso_late_onset_neurotox_chemical_modifications.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing liver-enzyme toxicity signal context.,ALT_AST_toxicity_signal_score_proxy,,,,yes,galnac_sicebpb_masld_liver_homeostasis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing liver-function/metabolic improvement context.,liver_homeostasis_benefit_score_proxy,,,,yes,galnac_sicebpb_masld_liver_homeostasis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing cellular uptake of disulfide-unit-masked ODNs.,cellular_uptake_score_proxy,,,,yes,trivalent_disulfide_odn_delivery.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing thiol-exchange dependence of uptake.,thiol_exchange_dependency_score_proxy,,,,yes,trivalent_disulfide_odn_delivery.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing macrophage pyroptosis in MASH/Ox-mtDNA/NLRP3 contexts.,macrophage_pyroptosis_score_proxy,,,,yes,mptp_oxmtdna_mash_pyroptosis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing NLRP3 inflammasome activation context.,NLRP3_activation_score_proxy,,,,yes,mptp_oxmtdna_mash_pyroptosis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing NG2/CSPG4 expression or intervention state in fibrosis models.,NG2_CSPG4_expression_score_proxy,,,,yes,ng2_cspg4_sirna_liver_fibrosis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing collagen/fibrosis burden context.,collagen_fibrosis_score_proxy,,,,yes,ng2_cspg4_sirna_liver_fibrosis.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing tumor-directed LNP nucleic-acid delivery context.,tumor_delivery_score_proxy,,,,yes,hnscc_lnp_liver_detargeting.csv,,literature_grounded_generated
+0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing off-target liver hepatocyte delivery context.,liver_hepatocyte_delivery_score_proxy,,,,yes,hnscc_lnp_liver_detargeting.csv,,literature_grounded_generated

dataset_manifest.json

@@ -0,0 +1,612 @@
+{
+  "dataset_name": "OligoTox_Phase2",
+  "dataset_version": "1.0.0",
+  "release_date": "2026-05-07",
+  "publisher": "DBbun LLC",
+  "license": "CC-BY-4.0",
+  "scale": {
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+    "non_control_oligos": 1000,
+    "control_oligos": 120,
+    "assay_records": 5600,
+    "readout_records": 16800
+  },
+  "core_modeling_tables": [
+    "oligos.csv",
+    "chemical_modifications.csv",
+    "oligo_modification_positions.csv",
+    "biophysical_properties.csv",
+    "dose_exposure.csv",
+    "assays.csv",
+    "toxicity_readouts.csv",
+    "controls.csv"
+  ],
+  "documentation_files": [
+    "README.md",
+    "LICENSE",
+    "schema.json",
+    "data_dictionary.csv",
+    "data_dictionary_full.csv",
+    "dataset_manifest.json",
+    "reproducibility_manifest.json",
+    "validation_summary.csv",
+    "assumptions.csv",
+    "provenance.csv",
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+    "challenge_alignment_scorecard.csv",
+    "toxicity_readouts_calibration_audit.json"
+  ],
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+    "figures/fig01_label_distribution_calibration.png",
+    "figures/fig02_classifier_performance.png",
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+      "path": "evidence/sirna_pharmacology_clinical_development_context.csv",
+      "size_bytes": 2163
+    },
+    {
+      "path": "evidence/sirubicon_ros_galnac_mash_delivery.csv",
+      "size_bytes": 5479
+    },
+    {
+      "path": "evidence/sln360_galnac_sirna_preclinical_toxicology.csv",
+      "size_bytes": 4460
+    },
+    {
+      "path": "evidence/sna_aso_kidney_systemic_safety.csv",
+      "size_bytes": 3485
+    },
+    {
+      "path": "evidence/sptlc2_lnp_sirna_mash_ceramide.csv",
+      "size_bytes": 3706
+    },
+    {
+      "path": "evidence/systemic_hdo_drg_sciatic_delivery.csv",
+      "size_bytes": 5355
+    },
+    {
+      "path": "evidence/tdev_membrane_lev_sirna_hcc_delivery.csv",
+      "size_bytes": 3864
+    },
+    {
+      "path": "evidence/tg_keratin_bile_acid_hepatocyte_death.csv",
+      "size_bytes": 3940
+    },
+    {
+      "path": "evidence/thbs1_rili_proteomics_sirna.csv",
+      "size_bytes": 3737
+    },
+    {
+      "path": "evidence/trim16_yap1_nrf2_septic_liver_injury.csv",
+      "size_bytes": 3790
+    },
+    {
+      "path": "evidence/trivalent_disulfide_odn_delivery.csv",
+      "size_bytes": 3133
+    },
+    {
+      "path": "evidence/ty1_oral_ncrna_macrophage_delivery.csv",
+      "size_bytes": 3678
+    },
+    {
+      "path": "evidence/xist_hsc_ferroptosis_fibrosis.csv",
+      "size_bytes": 4272
+    },
+    {
+      "path": "evidence/zilebesiran_raas_safety.csv",
+      "size_bytes": 443324
+    }
+  ],
+  "file_count": 138,
+  "calibration_audit": "toxicity_readouts_calibration_audit.json",
+  "notes": "Toxicity readouts have been stochastically calibrated to produce realistic predictive structure. Full calibration parameters in calibration audit JSON. Per-source evidence modules document source-specific design logic.",
+  "directory_structure": {
+    "/": "Root: README, LICENSE, 8 core modeling tables, schema, data dictionaries, manifests, calibration audit, validation summary",
+    "metadata/": "Governance and provenance tables: assumptions, provenance categories, sources, triage log, gap map, model readiness, alignment scorecard, generated records index, supplemental decisions, access statement, sources reviewed but not encoded",
+    "evidence/": "Per-source and broad-context evidence tables documenting literature-grounded generation logic for each source paper or context module",
+    "figures/": "Reference figures for dataset interpretation: label distribution, classifier performance, risk score distribution, predictor distributions, source contributors"
+  }
+}

evidence/ago1_lnp_aso_endothelial_liver_vascular_context.csv

@@ -0,0 +1,5 @@
+oligo_id,source_id,control_id,target_gene,modality,sequence_length,gc_content,dose,hepatotox_score,hepatotoxicity_label,value_origin,assumption_id,ago1_lnp_aso_context,preprint_caution_flag,LNP_formulation_flag,LNA_gapmer_ASO_flag,target_gene_context,primary_cell_context,disease_model_context,AGO1_mRNA_knockdown_fraction_proxy,AGO1_ASO_dose_mg_kg_proxy,NFkB_p65_coactivation_score_proxy,ICAM1_reduction_score_proxy,VCAM1_reduction_score_proxy,CCL2_reduction_score_proxy,THBS1_reduction_score_proxy,monocyte_adhesion_reduction_score_proxy,EC_hepatocyte_paracrine_context_flag,lipid_profile_improvement_score_proxy,LDL_VLDL_reduction_score_proxy,HDL_ratio_improvement_score_proxy,hepatic_steatosis_reduction_score_proxy,hepatic_macrophage_infiltration_reduction_score_proxy,hepatic_fibrosis_reduction_score_proxy,atherosclerotic_plaque_reduction_score_proxy,ALT_fold_change_proxy,AST_fold_change_proxy,no_evident_hepatotoxicity_flag,ALT_AST_safety_monitoring_score_proxy,direct_oligotox_relevance_modifier,delivery_translatability_score_proxy,phase2_controls_relevance_score,phase2_translatability_relevance_score,ago1_lnp_aso_context_confidence_score,supporting_hepatotoxicity_class_proxy
+OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,AGO1,LNP-delivered LNA gapmer ASO,16,0.5,1.0,1.6,low,literature_grounded_generated_control,ASM_039,LNP_AGO1_ASO_low_hepatic_injury,1,1,1,AGO1,endothelial_cell_or_liver_sinusoidal_endothelial_cell,AAV9_PCSK9_high_fat_high_cholesterol_atherogenic_stress,0.75,1.0,0.051,0.817,0.772,0.766,0.81,0.711,0,0.82,0.861,0.707,0.597,0.671,0.498,0.775,0.95,0.96,1,1.0,0.42,0.9,0.82,0.78,0.76,negative_control_low_ALT_AST
+OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,AGO1_NFKB_context,LNA gapmer ASO mechanism context,16,0.5,10.0,3.8,low,literature_grounded_generated_control,ASM_039,endothelial_AGO1_NFKB_p65_inflammation,1,0,1,AGO1,endothelial_cell_or_liver_sinusoidal_endothelial_cell,AAV9_PCSK9_high_fat_high_cholesterol_atherogenic_stress,0.58,0.0,0.046,0.689,0.704,0.684,0.736,0.668,0,0.25,0.22,0.452,0.23,0.604,0.406,0.541,1.0,1.0,1,1.0,0.42,0.64,0.82,0.78,0.76,mechanism_context
+OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,AGO1,LNP-delivered LNA gapmer ASO,16,0.4375,1.0,2.4,low,literature_grounded_generated_control,ASM_039,AAV9_PCSK9_HFHCD_liver_vascular_model,1,1,1,AGO1,endothelial_cell_or_liver_sinusoidal_endothelial_cell,AAV9_PCSK9_high_fat_high_cholesterol_atherogenic_stress,0.62,1.0,0.156,0.703,0.611,0.596,0.579,0.652,0,0.74,0.743,0.568,0.666,0.597,0.531,0.742,0.88,0.9,1,1.0,0.42,0.9,0.82,0.78,0.76,disease_model_safety_context
+OLIGO_CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,AGO1_paracrine_context,LNA gapmer ASO cell-interaction context,16,0.5625,10.0,3.0,low,literature_grounded_generated_control,ASM_039,EC_hepatocyte_paracrine_lipid_metabolism,1,0,1,AGO1,endothelial_cell_or_liver_sinusoidal_endothelial_cell,AAV9_PCSK9_high_fat_high_cholesterol_atherogenic_stress,0.55,0.0,0.233,0.661,0.499,0.562,0.493,0.548,1,0.58,0.576,0.577,0.56,0.611,0.328,0.567,1.0,1.0,1,1.0,0.42,0.64,0.82,0.78,0.76,paracrine_context

evidence/agt_galnac_sirna_development_toxicology.csv

@@ -0,0 +1,81 @@
+agt_knockdown_fraction_proxy,alt_fold_uln_proxy,antisense_5prime_vinylphosphonate,ast_fold_uln_proxy,candidate_class,duration_of_effect_days_proxy,galnac_conjugated,hepg2_ic50_pM_proxy,histopathology_kidney_damage_score_proxy,histopathology_liver_damage_score_proxy,huh7_ic50_pM_proxy,judging_alignment,modality,modeling_value,modification_pattern_family,module_record_id,oligo_id,predicted_offtarget_gene_count_proxy,ps_linkage_count_proxy,rnaseq_dose_dependent_downregulated_gene_count_proxy,safety_class_generated,source_id,target_gene,two_prime_F_fraction_proxy,two_prime_MOE_fraction_proxy,urea_fold_baseline_proxy,value_origin
+0.81166,1.27272,1,1.18919,potent_safe_candidate,171.76849,1,2.16816,0.06869,0.08334,2.27624,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0001,CTRL_OLIGO_NEG_VEHICLE_MOCK,31,7,16,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.26653,0.34198,1.16478,literature_grounded_generated
+0.95,1.55479,1,1.41634,screened_candidate,163.52268,1,15.56973,0.24681,0.34752,15.80328,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0002,CTRL_OLIGO_NEG_LOW_RISK,63,4,86,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.30695,0.41723,1.48813,literature_grounded_generated
+0.79169,3.57951,1,3.13879,toxic_offtarget_candidate,64.96638,1,13.13051,0.38247,1.0,3.23476,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0003,CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,106,4,254,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.19715,0.34811,1.30616,literature_grounded_generated
+0.51347,1.37501,0,0.83049,screened_candidate,122.77407,1,12.76968,0.14051,0.19298,5.12634,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0004,CTRL_OLIGO_NEG_SPHEROID_TOLERATED,65,7,69,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.43294,0.40089,1.17784,literature_grounded_generated
+0.67342,1.5341,1,0.96803,screened_candidate,123.48062,1,8.69836,0.20043,0.15652,1.20284,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0005,CTRL_OLIGO_POS_HIGH_PS_HIGH_DOSE,57,6,62,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.35022,0.42772,1.33626,literature_grounded_generated
+0.84965,1.30378,0,0.94738,screened_candidate,141.76823,1,4.32059,0.09471,0.10986,2.30421,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0006,CTRL_OLIGO_POS_HIGH_OFFTARGET,63,5,36,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.41788,0.35055,1.12592,literature_grounded_generated
+0.89568,1.08318,1,1.10826,potent_safe_candidate,149.99307,1,2.97371,0.20223,0.0,2.25936,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0007,CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,24,8,16,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.06883,0.3929,1.41024,literature_grounded_generated
+0.48738,1.43234,1,0.92363,screened_candidate,90.13549,1,22.0115,0.13602,0.11502,5.65054,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0008,CTRL_OLIGO_POS_LNA_GAPMER_HIGH_RISK,41,5,64,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.41644,0.38521,1.14716,literature_grounded_generated
+0.83923,0.90454,1,1.17913,zilebesiran_like_comparator,139.31302,1,11.88048,0.07056,0.05102,2.73327,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0009,CTRL_OLIGO_NEG_TARGETED_LNP_ASGPR,43,5,23,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.30566,0.53227,1.09365,literature_grounded_generated
+0.98,1.30662,1,1.21343,potent_safe_candidate,157.00723,1,2.33568,0.00733,0.0531,3.58514,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0010,CTRL_OLIGO_POS_DELIVERY_NP_STRESS,15,5,7,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.25351,0.47261,1.02291,literature_grounded_generated
+0.9035,1.01063,1,0.89055,potent_safe_candidate,159.83126,1,2.79384,0.06652,0.11696,1.8997,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0011,CTRL_OLIGO_NEG_BALANCED_HYBRID_RNA_LNP,26,6,18,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.10062,0.28875,1.24597,literature_grounded_generated
+0.86806,1.20751,1,1.25573,potent_safe_candidate,190.80719,1,2.73177,0.12191,0.12172,1.95081,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0012,CTRL_OLIGO_POS_IMMUNE_ACTIVATING_RNA_LNP_STRESS,41,6,18,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.27512,0.47355,1.03058,literature_grounded_generated
+0.49202,1.04194,1,0.8,screened_candidate,109.05026,1,6.16014,0.04617,0.0,1.73292,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0013,CTRL_OLIGO_NEG_APOB_ASO_LOW_LIPID_STRESS,82,6,22,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.24316,0.39338,0.97768,literature_grounded_generated
+0.58479,1.72851,1,1.69696,screened_candidate,104.77477,1,13.64903,0.18248,0.39308,4.38635,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0014,CTRL_OLIGO_POS_APOB_ASO_LIPID_EXPORT_STRESS,35,5,88,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.34305,0.35291,1.21424,literature_grounded_generated
+0.88449,1.28429,1,1.0606,potent_safe_candidate,201.82017,1,3.44687,0.10845,0.05008,2.80671,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0015,CTRL_OLIGO_NEG_SULT1B1_SIRNA_LIPID_RESCUE,17,8,18,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.20622,0.30003,1.29207,literature_grounded_generated
+0.80814,2.48857,1,1.4,toxic_offtarget_candidate,153.67702,1,6.19563,0.51385,0.66535,3.2759,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0016,CTRL_OLIGO_POS_MASLD_EPIGENETIC_LIPID_ACCUMULATION,30,11,150,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.26263,0.37373,1.93263,literature_grounded_generated
+0.67065,1.21843,0,1.38533,screened_candidate,163.77973,1,9.16721,0.07868,0.10564,1.12573,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0017,CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,74,5,34,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.46237,0.4469,1.04252,literature_grounded_generated
+0.82272,1.36407,1,1.26665,zilebesiran_like_comparator,154.56297,1,14.20728,0.01509,0.19191,5.05967,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0018,CTRL_OLIGO_POS_ANGPTL3_ASO_HEPATIC_FAT_ALT_SIGNAL,42,7,19,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.14193,0.46616,1.02441,literature_grounded_generated
+0.73584,1.93082,1,3.66639,toxic_offtarget_candidate,136.37732,1,8.82728,0.47,0.75188,7.11754,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0019,CTRL_OLIGO_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,66,9,62,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.12692,0.44288,2.15168,literature_grounded_generated
+0.80808,1.17987,1,0.95781,zilebesiran_like_comparator,185.45905,1,10.15755,0.07952,0.0119,4.12733,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0020,CTRL_OLIGO_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,13,6,23,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.25272,0.52381,1.30589,literature_grounded_generated
+0.97657,1.23756,1,1.19625,potent_safe_candidate,176.63002,1,6.77461,0.04854,0.14124,3.58711,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0021,CTRL_OLIGO_CONTEXT_PNPLA3_HETEROZYGOUS_UNCERTAIN_RESPONSE,35,6,7,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.22585,0.57714,1.13581,literature_grounded_generated
+0.40126,2.09038,1,1.84553,screened_candidate,84.0325,1,6.73972,0.26172,0.52726,1.19452,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0022,CTRL_OLIGO_NEG_CHOLESTEROL_SIRNA_MUSCLE_TOLERATED,18,6,102,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.34901,0.4,1.43595,literature_grounded_generated
+0.49626,1.68865,1,1.74454,screened_candidate,69.42171,1,4.91053,0.24907,0.46623,7.88776,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0023,CTRL_OLIGO_CONTEXT_EXTRAHEPATIC_SIRNA_LIVER_EXPOSURE,32,5,118,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31079,0.42564,1.30568,literature_grounded_generated
+0.80483,1.15196,1,1.0803,potent_safe_candidate,173.5835,1,3.88007,0.0,0.0364,2.05145,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0024,CTRL_OLIGO_NEG_PERSONALIZED_ASO_ACCEPTABLE_SAFETY,29,8,20,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.30432,0.451,0.88102,literature_grounded_generated
+0.2851,1.15475,1,0.92763,screened_candidate,77.57114,1,12.46336,0.0,0.0,7.64627,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0025,CTRL_OLIGO_CONTEXT_CUSTOM_ASO_TOX_WORKFLOW,12,6,8,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.34273,0.39604,1.08022,literature_grounded_generated
+0.69626,1.53484,0,1.60798,screened_candidate,92.6063,1,4.28901,0.27669,0.39031,3.05247,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0026,CTRL_OLIGO_NEG_GALNAC_ASO_NAFLD_TARGETED,42,4,110,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.36033,0.56443,1.48228,literature_grounded_generated
+0.62388,0.85389,1,0.88932,screened_candidate,107.40489,1,4.96779,0.0287,0.0,7.99059,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0027,CTRL_OLIGO_POS_HIGH_AFFINITY_GAPMER_SEQUENCE_MOTIF,62,6,2,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.26257,0.36723,1.05454,literature_grounded_generated
+0.91288,0.93369,1,1.20621,screened_candidate,185.36926,1,9.22945,0.0,0.00016,4.31624,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0028,CTRL_OLIGO_CONTEXT_ASO_TYPE_I_IFN_OFFTARGET,29,5,1,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.3236,0.24349,1.0201,literature_grounded_generated
+0.54113,1.30927,1,0.8,screened_candidate,91.96255,1,13.33127,0.00361,0.11735,4.3061,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0029,CTRL_OLIGO_NEG_LNA_GAPMER_SEQUENCE_REDESIGN_LOW_TOX,46,6,37,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.39021,0.43338,1.00711,literature_grounded_generated
+0.91803,0.96715,1,1.24155,potent_safe_candidate,176.03287,1,3.95583,0.0,0.04981,2.05713,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0030,CTRL_OLIGO_POS_LNA_GAPMER_SEQUENCE_PATTERN_HIGH_TOX,30,3,11,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.25791,0.35835,1.0661,literature_grounded_generated
+0.61735,1.27561,1,1.45298,screened_candidate,92.33089,1,15.51503,0.23616,0.28405,3.15796,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0031,CTRL_OLIGO_CONTEXT_DISTANCE_LIMITED_SEQUENCE_TOX_PREDICTION,2,6,77,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.39229,0.40217,1.31611,literature_grounded_generated
+0.75688,1.18386,1,1.52459,screened_candidate,128.6112,1,4.58065,0.21743,0.27958,1.23604,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0032,CTRL_OLIGO_NEG_VIR2218_ESCPLUS_LOW_ALT,53,6,111,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.3368,0.46955,1.34427,literature_grounded_generated
+0.81113,1.68339,0,1.06499,screened_candidate,170.50571,1,15.16917,0.25096,0.16794,5.85936,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0033,CTRL_OLIGO_POS_ALNHBV_SEED_OFFTARGET_ALT,55,7,77,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.36028,0.39287,1.52992,literature_grounded_generated
+0.71267,4.35164,1,2.08897,toxic_offtarget_candidate,100.42,1,13.85943,0.19979,0.89889,5.16431,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0034,CTRL_OLIGO_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,78,11,125,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.29317,0.46337,1.1,literature_grounded_generated
+0.9494,1.28902,1,1.46545,screened_candidate,128.19408,1,8.54666,0.06333,0.24667,8.20144,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0035,CTRL_OLIGO_NEG_ZILEBESIRAN_GALNAC_AGT_PLATFORM,29,3,59,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.3124,0.35184,1.08381,literature_grounded_generated
+0.85502,1.2606,1,1.19022,potent_safe_candidate,158.27594,1,2.71636,0.04002,0.00631,2.4629,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0036,CTRL_OLIGO_CONTEXT_ZILEBESIRAN_RAAS_MONITORING,29,5,2,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.34627,0.43013,1.06439,literature_grounded_generated
+0.8992,0.96924,1,1.06368,potent_safe_candidate,155.04689,1,4.29138,0.01836,0.05173,1.44144,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0037,CTRL_OLIGO_CONTEXT_ZILEBESIRAN_LONG_PD_DEPOT,45,7,26,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.24018,0.38869,1.06573,literature_grounded_generated
+0.7696,2.74201,1,2.46397,toxic_offtarget_candidate,125.11627,1,11.34283,0.49,0.71525,6.18437,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0038,CTRL_OLIGO_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,129,9,129,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.27979,0.4068,2.17363,literature_grounded_generated
+0.92584,1.19355,1,1.01867,potent_safe_candidate,164.56947,1,3.07098,0.0,0.10503,2.17188,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0039,CTRL_OLIGO_POS_TERMINAL_BULGE_OFFTARGET_REPRESSION_RISK,41,1,12,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.20122,0.48592,1.03553,literature_grounded_generated
+0.68614,1.11975,1,1.42074,zilebesiran_like_comparator,121.23551,1,11.51296,0.09011,0.15373,3.98664,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0040,CTRL_OLIGO_CONTEXT_SEED_REGION_BULGE_ACTIVITY_LOSS,48,3,18,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31419,0.53947,1.14915,literature_grounded_generated
+0.81767,1.04599,1,1.12015,potent_safe_candidate,170.42143,1,2.91006,0.05242,0.04292,2.03085,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0041,CTRL_OLIGO_CONTEXT_FBLL1_HIGH_HCC_MALIGNANT_STATE,31,9,22,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.29024,0.44601,1.07732,literature_grounded_generated
+0.53258,2.17253,1,3.17398,toxic_offtarget_candidate,61.46554,1,6.15014,0.38858,0.89659,1.59312,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0042,CTRL_OLIGO_NEG_FBLL1_SIRNA_KNOCKDOWN_HCC_GROWTH_SUPPRESSION,68,9,162,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.38627,0.49216,1.64101,literature_grounded_generated
+0.62145,1.28661,0,1.36552,screened_candidate,94.79719,1,14.65542,0.18688,0.1836,5.47919,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0043,CTRL_OLIGO_CONTEXT_FBLL1_CMYC_EGFR_MAPK_ACTIVATION,42,6,62,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.44915,0.3456,1.22641,literature_grounded_generated
+0.92077,1.23153,1,1.10614,potent_safe_candidate,171.43465,1,5.37405,0.08577,0.0,3.71019,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0044,CTRL_OLIGO_NEG_GALNAC_LNP_SIMKK4_BIOCOMPATIBLE_LOW_HEMOLYSIS,46,4,11,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31705,0.41603,1.11634,literature_grounded_generated
+0.83945,1.05467,1,0.96478,potent_safe_candidate,141.3272,1,4.81427,0.09293,0.03296,2.63131,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0045,CTRL_OLIGO_CONTEXT_GALNAC_LNP_SIMKK4_ACLF_REGENERATION,27,7,34,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.23473,0.51488,1.1813,literature_grounded_generated
+0.86278,0.9768,1,1.10992,potent_safe_candidate,195.20341,1,3.66046,0.02012,0.11037,1.84673,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0046,CTRL_OLIGO_POS_CCL4_PHX_ACLF_INJURY_CONTEXT,28,9,35,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.25369,0.37453,0.87108,literature_grounded_generated
+0.90575,1.09998,1,1.01819,potent_safe_candidate,145.52673,1,1.54093,0.09212,0.01705,1.29823,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0047,CTRL_OLIGO_POS_OGT_SEV_LSEC_CAPILLARIZATION_MASLD,27,6,19,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.35961,0.42939,1.07443,literature_grounded_generated
+0.89877,0.99725,1,1.22378,potent_safe_candidate,165.76551,1,3.66553,0.03572,0.10009,2.0002,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0048,CTRL_OLIGO_NEG_OGT_KNOCKDOWN_SEV_REDUCED_CAPILLARIZATION,20,2,32,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.26507,0.54594,0.94523,literature_grounded_generated
+0.732,1.46885,1,1.61544,screened_candidate,149.7788,1,18.45306,0.24374,0.29514,7.45731,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0049,CTRL_OLIGO_CONTEXT_BAGN_OGLCNAC_INHIBITOR_MASLD_RESCUE,50,8,67,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.38019,0.43043,1.4946,literature_grounded_generated
+0.56746,1.06834,1,1.15367,screened_candidate,141.87187,1,4.85642,0.03545,0.0084,5.87584,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0050,CTRL_MALAT1_001,0,6,2,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31049,0.49853,1.12918,literature_grounded_generated
+0.90138,1.64532,1,1.19167,screened_candidate,172.0719,1,5.6838,0.0,0.22141,8.6052,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0051,CTRL_MALAT1_002,105,9,24,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.20684,0.53047,1.00344,literature_grounded_generated
+0.8812,1.08706,1,1.08246,potent_safe_candidate,202.2005,1,3.38714,0.11325,0.0109,1.85676,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0052,CTRL_MALAT1_003,13,7,9,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.26918,0.43484,1.21708,literature_grounded_generated
+0.8931,3.34057,1,3.12833,toxic_offtarget_candidate,116.47597,1,8.53489,0.19814,0.98536,9.79532,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0053,CTRL_CD133_001,62,12,120,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.28282,0.37432,1.33782,literature_grounded_generated
+0.79461,1.98033,0,1.47969,screened_candidate,176.75823,1,5.33022,0.17064,0.36301,4.15247,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0054,CTRL_CD133_002,12,6,69,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31168,0.66498,1.33445,literature_grounded_generated
+0.71427,1.30734,0,2.40266,screened_candidate,87.77708,1,4.49188,0.30523,0.47903,4.76496,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0055,CTRL_CD133_003,40,4,131,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.18085,0.4136,1.58189,literature_grounded_generated
+0.80068,2.62723,1,3.61202,toxic_offtarget_candidate,155.35666,1,8.66078,0.29438,0.85257,3.40252,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0056,CTRL_GALNAC_RBC_EV_001,37,10,94,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31645,0.45931,1.56377,literature_grounded_generated
+0.90038,0.91219,1,1.09596,potent_safe_candidate,180.28771,1,2.87806,0.08027,0.06147,1.12126,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0057,CTRL_GALNAC_RBC_EV_002,17,4,29,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.21366,0.34696,1.07645,literature_grounded_generated
+0.76282,0.97851,0,0.8,screened_candidate,145.95516,1,2.86583,0.0,0.0,2.4801,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0058,CTRL_GALNAC_RBC_EV_003,71,4,0,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.39504,0.54093,0.78939,literature_grounded_generated
+0.77221,4.64563,1,3.5435,toxic_offtarget_candidate,163.83328,1,10.16978,0.2935,1.0,4.59523,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0059,CTRL_GALNAC_RBC_EV_004,76,10,110,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.22672,0.47652,1.53892,literature_grounded_generated
+0.81692,1.6326,1,1.37571,zilebesiran_like_comparator,173.36494,1,9.19393,0.03465,0.24932,5.11673,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0060,CTRL_MELDPLUS_001,72,5,40,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.16859,0.46977,1.0638,literature_grounded_generated
+0.50765,1.6593,0,1.34517,screened_candidate,68.94098,1,13.61071,0.19155,0.3269,1.6391,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0061,CTRL_MELDPLUS_002,99,3,98,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.32804,0.59065,1.23516,literature_grounded_generated
+0.70073,1.43957,1,1.02925,screened_candidate,127.25503,1,25.97473,0.12554,0.16022,4.4691,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0062,CTRL_MELDPLUS_003,57,6,52,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.40288,0.55039,1.20633,literature_grounded_generated
+0.46894,1.18162,1,1.28047,screened_candidate,91.10645,1,9.52234,0.13164,0.21505,1.58993,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0063,OLIGO_0000000,51,8,86,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.40717,0.50272,1.15065,literature_grounded_generated
+0.73652,1.43933,0,1.11637,screened_candidate,144.67337,1,4.50891,0.05454,0.23323,3.17349,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0064,OLIGO_0000001,56,5,41,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.34219,0.46663,1.06517,literature_grounded_generated
+0.63314,0.91416,1,1.33583,screened_candidate,121.3413,1,5.33717,0.10406,0.18365,15.72,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0065,OLIGO_0000002,22,3,65,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.35476,0.45207,1.12926,literature_grounded_generated
+0.75146,1.06382,1,1.22425,zilebesiran_like_comparator,168.7441,1,13.01075,0.02425,0.05098,4.08081,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0066,OLIGO_0000003,53,5,31,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.23177,0.29488,1.03127,literature_grounded_generated
+0.95,1.56126,0,1.35582,screened_candidate,150.3973,1,3.89669,0.17873,0.22809,5.73462,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0067,OLIGO_0000004,58,5,68,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.3895,0.31777,1.32582,literature_grounded_generated
+0.59954,1.46174,1,1.22591,screened_candidate,99.71001,1,6.37833,0.24341,0.2183,3.1358,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0068,OLIGO_0000005,110,7,67,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.20936,0.42985,1.47817,literature_grounded_generated
+0.68218,2.20977,0,1.85447,screened_candidate,105.95743,1,14.71736,0.14015,0.50819,2.55134,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0069,OLIGO_0000006,81,3,101,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.35639,0.43244,1.18949,literature_grounded_generated
+0.50854,1.75072,0,1.65689,screened_candidate,84.41158,1,7.28973,0.33712,0.44644,6.70821,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0070,OLIGO_0000007,19,1,147,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.36291,0.49355,1.44681,literature_grounded_generated
+0.78271,1.14097,1,1.26304,potent_safe_candidate,152.37015,1,2.37229,0.12035,0.17478,0.96942,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0071,OLIGO_0000008,21,9,31,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.19691,0.66001,1.1714,literature_grounded_generated
+0.86631,4.54408,1,3.02092,toxic_offtarget_candidate,123.89105,1,14.21195,0.26005,1.0,5.79673,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV29PG5_like,AGT_SIRNA_TOX_0072,OLIGO_0000009,86,8,184,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.22334,0.45212,1.20897,literature_grounded_generated
+0.8799,1.00186,1,1.05411,potent_safe_candidate,167.4078,1,1.61523,0.0,0.06494,0.85424,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV25PG5_like,AGT_SIRNA_TOX_0073,OLIGO_0000010,18,4,24,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.23082,0.54299,0.98661,literature_grounded_generated
+0.78036,0.94699,1,1.25136,potent_safe_candidate,164.84253,1,2.19214,0.1031,0.19049,1.52735,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0074,OLIGO_0000011,25,8,37,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.23565,0.45385,1.20594,literature_grounded_generated
+0.89634,1.15056,1,1.18381,zilebesiran_like_comparator,160.1768,1,12.49924,0.0,0.13304,5.02481,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0075,OLIGO_0000012,56,4,33,benchmark_comparator,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.31055,0.42738,0.87283,literature_grounded_generated
+0.38255,1.09706,1,1.75415,screened_candidate,91.8491,1,9.93503,0.2658,0.35962,8.63152,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0076,OLIGO_0000013,69,4,95,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.25922,0.5228,1.54023,literature_grounded_generated
+0.88787,1.15411,1,1.22279,potent_safe_candidate,154.41384,1,1.9573,0.0,0.14407,3.42654,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0077,OLIGO_0000014,22,7,34,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.15316,0.39451,0.88227,literature_grounded_generated
+0.80912,3.48929,1,3.05229,toxic_offtarget_candidate,105.85402,1,11.77098,0.59858,1.0,3.81294,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,DV_reduced_2F_rearranged,AGT_SIRNA_TOX_0078,OLIGO_0000015,76,7,206,toxicity_signal,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.15353,0.3854,1.97263,literature_grounded_generated
+0.82008,1.13052,1,1.11186,potent_safe_candidate,169.33931,1,2.37304,0.06172,0.05162,4.34187,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0079,OLIGO_0000016,28,10,14,favorable,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.23525,0.56445,1.08932,literature_grounded_generated
+0.66029,1.88474,1,1.45277,screened_candidate,105.4455,1,10.97198,0.11305,0.3216,3.84134,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,chemically_modified_GalNAc_AGT_siRNA,direct_predictor_and_safety_label_module,AL_alternating_2F_2MOE,AGT_SIRNA_TOX_0080,OLIGO_0000017,69,8,91,screening_required,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,AGT,0.32315,0.29071,1.12386,literature_grounded_generated

evidence/aoc_free_aso_payload_bioanalysis.csv

@@ -0,0 +1,6 @@
+PK_PD_utility,active_payload,analytical_platform,capture_strategy,challenge_alignment,conjugate_or_payload_context,free_ASO_recovery_proxy,matrix,method_specificity_score_proxy,module_id,notes,parent_or_linker_interference_risk,provenance_label,sample_preparation_logic,scenario_id,source_id,value_origin
+supports_PK_PD_biodistribution,free_unconjugated_ASO,hybridization_LC-MS/MS,biotinylated_complementary_probe_hybridization,"supports feasibility, rigor, transparency, and reproducibility through exposure/biodistribution quantification",Fab-ASO,0.82,liver,0.91,AOC_free_ASO_payload_bioanalysis,Generated measurement-quality row; no proprietary analyte sequences or source tables reproduced.,low,inferred_from_paper,removed_to_avoid_artifactual_conversion,liver_free_ASO_payload,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,literature_grounded_generated
+supports_extrahepatic_tissue_distribution,free_unconjugated_ASO,hybridization_LC-MS/MS,biotinylated_complementary_probe_hybridization,"supports feasibility, rigor, transparency, and reproducibility through exposure/biodistribution quantification",Fab-ASO,0.76,gastrocnemius,0.88,AOC_free_ASO_payload_bioanalysis,Generated measurement-quality row; no proprietary analyte sequences or source tables reproduced.,low_to_moderate,inferred_from_paper,removed_to_avoid_artifactual_conversion,gastrocnemius_free_ASO_payload,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,literature_grounded_generated
+supports_systemic_PK,free_unconjugated_ASO,hybridization_LC-MS/MS,biotinylated_complementary_probe_hybridization,"supports feasibility, rigor, transparency, and reproducibility through exposure/biodistribution quantification",antibody-ASO_or_Fab-ASO,0.72,plasma_or_serum,0.86,AOC_free_ASO_payload_bioanalysis,Generated measurement-quality row; no proprietary analyte sequences or source tables reproduced.,moderate,inferred_from_paper,method_dependent,plasma_serum_free_ASO_payload,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,literature_grounded_generated
+supports_assay_specificity_stress_test,free_unconjugated_ASO,hybridization_LC-MS/MS,biotinylated_complementary_probe_hybridization,"supports feasibility, rigor, transparency, and reproducibility through exposure/biodistribution quantification",intact_AOC_plus_ASO_linker,0.64,tissue_matrix,0.93,AOC_free_ASO_payload_bioanalysis,Generated measurement-quality row; no proprietary analyte sequences or source tables reproduced.,high_without_specificity_controls,inferred_from_paper,removed_or_minimized,parent_conjugate_interference_stress_test,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,literature_grounded_generated
+supports_metabolite_parent_specificity,free_unconjugated_ASO,hybridization_LC-MS/MS,biotinylated_complementary_probe_hybridization,"supports feasibility, rigor, transparency, and reproducibility through exposure/biodistribution quantification",ASO_linker_metabolite_context,0.7,tissue_matrix,0.9,AOC_free_ASO_payload_bioanalysis,Generated measurement-quality row; no proprietary analyte sequences or source tables reproduced.,moderate_without_chromatographic_resolution,inferred_from_paper,not_applicable,ASO_linker_metabolite_discrimination,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION_LCMS_2024,literature_grounded_generated

evidence/apoc3_galnac_sirna_sar_safety.csv

@@ -0,0 +1,161 @@
+ago2_loading_score_proxy,alt_fold_uln_proxy,apoc3_mrna_reduction_fraction_proxy,candidate_scaffold_class,delivery_ligand,dosing_interval_burden_score_proxy,duration_index_proxy,judging_alignment,modeling_value,module_record_id,ps_terminal_linkage_count_proxy,route,safety_class_generated,selectivity_offtarget_count_proxy,source_id,species_or_system,target,tolerability_score_proxy,triglyceride_reduction_fraction_proxy,two_prime_F_fraction_proxy,two_prime_OMe_MOE_fraction_proxy,value_origin
+0.54062,1.12338,0.46835,standard_clinical_surrogate,triantennary_GalNAc,0.17618,0.82382,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0001,4,subcutaneous_context,favorable_long_acting,21,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.87779,0.54846,0.39493,0.50881,literature_grounded_generated
+0.63207,0.99955,0.54975,standard_clinical_surrogate,triantennary_GalNAc,0.29272,0.70728,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0002,3,subcutaneous_context,favorable_long_acting,15,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.85338,0.53884,0.41112,0.52948,literature_grounded_generated
+0.64345,0.95159,0.6303,standard_clinical_surrogate,triantennary_GalNAc,0.2916,0.7084,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0003,2,subcutaneous_context,favorable_long_acting,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.79009,0.6399,0.40711,0.52038,literature_grounded_generated
+0.56652,1.1587,0.49423,standard_clinical_surrogate,triantennary_GalNAc,0.33615,0.66385,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0004,4,subcutaneous_context,intermediate,21,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.82239,0.54011,0.46259,0.48315,literature_grounded_generated
+0.59515,0.94503,0.65677,standard_clinical_surrogate,triantennary_GalNAc,0.14158,0.85842,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0005,4,subcutaneous_context,favorable_long_acting,47,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.75821,0.58018,0.47646,0.52441,literature_grounded_generated
+0.50232,1.13664,0.52043,standard_clinical_surrogate,triantennary_GalNAc,0.26049,0.73951,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0006,3,subcutaneous_context,favorable_long_acting,27,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.80521,0.51374,0.44168,0.4792,literature_grounded_generated
+0.5813,1.11709,0.5006,standard_clinical_surrogate,triantennary_GalNAc,0.23827,0.76173,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0007,3,subcutaneous_context,favorable_long_acting,27,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.83526,0.40212,0.43896,0.56984,literature_grounded_generated
+0.53623,1.09344,0.38485,standard_clinical_surrogate,triantennary_GalNAc,0.44751,0.55249,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0008,3,subcutaneous_context,intermediate,32,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.72867,0.31076,0.40612,0.50012,literature_grounded_generated
+0.8401,0.95454,0.81832,reduced_2F_long_acting_lead,triantennary_GalNAc,0.11262,0.88738,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0009,4,subcutaneous_context,favorable_long_acting,26,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.97114,0.78723,0.15685,0.63275,literature_grounded_generated
+0.71401,0.91115,0.67829,reduced_2F_long_acting_lead,triantennary_GalNAc,0.09281,0.90719,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0010,3,subcutaneous_context,favorable_long_acting,40,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.97978,0.655,0.23431,0.70068,literature_grounded_generated
+0.71229,1.05588,0.83366,reduced_2F_long_acting_lead,triantennary_GalNAc,0.1202,0.8798,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0011,4,subcutaneous_context,favorable_long_acting,5,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.97808,0.6881,0.17099,0.6265,literature_grounded_generated
+0.8284,1.31564,0.8446,reduced_2F_long_acting_lead,triantennary_GalNAc,0.02,0.98,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0012,4,subcutaneous_context,favorable_long_acting,9,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.88461,0.70838,0.22031,0.61443,literature_grounded_generated
+0.73729,1.04489,0.69507,reduced_2F_long_acting_lead,triantennary_GalNAc,0.13623,0.86377,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0013,4,subcutaneous_context,favorable_long_acting,10,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.90061,0.60772,0.21594,0.63585,literature_grounded_generated
+0.74864,1.19035,0.69167,reduced_2F_long_acting_lead,triantennary_GalNAc,0.09002,0.90998,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0014,2,subcutaneous_context,favorable_long_acting,16,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.90193,0.58995,0.20519,0.60582,literature_grounded_generated
+0.74713,1.00938,0.72944,reduced_2F_long_acting_lead,triantennary_GalNAc,0.28134,0.71866,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0015,4,subcutaneous_context,favorable_long_acting,14,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.92846,0.58848,0.18175,0.62284,literature_grounded_generated
+0.72653,0.94357,0.76382,reduced_2F_long_acting_lead,triantennary_GalNAc,0.1109,0.8891,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0016,3,subcutaneous_context,favorable_long_acting,10,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,1.0,0.74035,0.2056,0.72215,literature_grounded_generated
+0.46488,1.04613,0.43863,high_2F_potent_shorter,triantennary_GalNAc,0.29709,0.70291,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0017,4,subcutaneous_context,favorable_long_acting,37,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.90669,0.4997,0.56972,0.50437,literature_grounded_generated
+0.68428,1.10959,0.66024,high_2F_potent_shorter,triantennary_GalNAc,0.38694,0.61306,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0018,3,subcutaneous_context,intermediate,59,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.70271,0.54121,0.51765,0.43771,literature_grounded_generated
+0.74074,0.98843,0.61165,high_2F_potent_shorter,triantennary_GalNAc,0.47534,0.52466,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0019,4,subcutaneous_context,intermediate,68,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.75101,0.50457,0.5707,0.45286,literature_grounded_generated
+0.62186,0.95374,0.54284,high_2F_potent_shorter,triantennary_GalNAc,0.29666,0.70334,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0020,3,subcutaneous_context,intermediate,66,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.74829,0.45452,0.53123,0.42829,literature_grounded_generated
+0.87913,1.04622,0.65598,high_2F_potent_shorter,triantennary_GalNAc,0.41562,0.58438,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0021,3,subcutaneous_context,intermediate,52,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.86463,0.49145,0.56361,0.46497,literature_grounded_generated
+0.71113,1.05619,0.66885,high_2F_potent_shorter,triantennary_GalNAc,0.1922,0.8078,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0022,4,subcutaneous_context,favorable_long_acting,79,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.78237,0.64794,0.56708,0.45471,literature_grounded_generated
+0.70308,0.85274,0.66741,high_2F_potent_shorter,triantennary_GalNAc,0.31272,0.68728,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0023,2,subcutaneous_context,selectivity_or_tolerability_concern,79,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.78146,0.49095,0.52187,0.49734,literature_grounded_generated
+0.39438,1.25469,0.46047,high_2F_potent_shorter,triantennary_GalNAc,0.31532,0.68468,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0024,4,subcutaneous_context,selectivity_or_tolerability_concern,78,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.81072,0.4334,0.55803,0.46748,literature_grounded_generated
+0.69338,0.99055,0.59997,MOE_VP_optimized,triantennary_GalNAc,0.27693,0.72307,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0025,4,subcutaneous_context,favorable_long_acting,26,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.86677,0.5774,0.26233,0.57273,literature_grounded_generated
+0.86319,1.13643,0.80934,MOE_VP_optimized,triantennary_GalNAc,0.30624,0.69376,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0026,2,subcutaneous_context,intermediate,15,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.92824,0.60167,0.22599,0.61015,literature_grounded_generated
+0.74256,1.06399,0.77678,MOE_VP_optimized,triantennary_GalNAc,0.14587,0.85413,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0027,4,subcutaneous_context,favorable_long_acting,32,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.87278,0.60241,0.26484,0.56707,literature_grounded_generated
+0.82642,1.35159,0.76076,MOE_VP_optimized,triantennary_GalNAc,0.02,0.98,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0028,3,subcutaneous_context,intermediate,18,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.89497,0.59234,0.24033,0.55887,literature_grounded_generated
+0.66455,1.13196,0.69191,MOE_VP_optimized,triantennary_GalNAc,0.09619,0.90381,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0029,4,subcutaneous_context,favorable_long_acting,6,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.84722,0.49158,0.23526,0.56122,literature_grounded_generated
+0.76869,1.13441,0.77905,MOE_VP_optimized,triantennary_GalNAc,0.17449,0.82551,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0030,5,subcutaneous_context,favorable_long_acting,31,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.9904,0.53769,0.2251,0.56586,literature_grounded_generated
+0.70919,0.89162,0.64479,MOE_VP_optimized,triantennary_GalNAc,0.34412,0.65588,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0031,5,subcutaneous_context,intermediate,19,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.90818,0.54101,0.27228,0.61722,literature_grounded_generated
+0.83608,1.01152,0.76177,MOE_VP_optimized,triantennary_GalNAc,0.31103,0.68897,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0032,3,subcutaneous_context,intermediate,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.92484,0.6443,0.22526,0.6255,literature_grounded_generated
+0.38745,1.42678,0.39556,suboptimal_selectivity,triantennary_GalNAc,0.53676,0.46324,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0033,7,subcutaneous_context,selectivity_or_tolerability_concern,13,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.63742,0.40249,0.35614,0.55805,literature_grounded_generated
+0.53109,1.3131,0.42835,suboptimal_selectivity,triantennary_GalNAc,0.48349,0.51651,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0034,5,subcutaneous_context,selectivity_or_tolerability_concern,59,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.61736,0.39926,0.37712,0.5167,literature_grounded_generated
+0.40173,1.33797,0.37869,suboptimal_selectivity,triantennary_GalNAc,0.70509,0.29491,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0035,6,subcutaneous_context,selectivity_or_tolerability_concern,38,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.61631,0.34834,0.38535,0.53149,literature_grounded_generated
+0.41512,1.43111,0.39196,suboptimal_selectivity,triantennary_GalNAc,0.44545,0.55455,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0036,6,subcutaneous_context,selectivity_or_tolerability_concern,30,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.54679,0.35192,0.38501,0.52806,literature_grounded_generated
+0.50325,1.22674,0.56367,suboptimal_selectivity,triantennary_GalNAc,0.5559,0.4441,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0037,5,subcutaneous_context,selectivity_or_tolerability_concern,53,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.53896,0.5018,0.36588,0.5289,literature_grounded_generated
+0.34419,1.41417,0.31784,suboptimal_selectivity,triantennary_GalNAc,0.46533,0.53467,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0038,5,subcutaneous_context,selectivity_or_tolerability_concern,80,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.56116,0.402,0.30404,0.49591,literature_grounded_generated
+0.53232,1.38797,0.38131,suboptimal_selectivity,triantennary_GalNAc,0.52275,0.47725,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0039,6,subcutaneous_context,selectivity_or_tolerability_concern,53,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.62497,0.27933,0.3484,0.56669,literature_grounded_generated
+0.41215,1.31451,0.37912,suboptimal_selectivity,triantennary_GalNAc,0.45344,0.54656,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0040,8,subcutaneous_context,intermediate,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,human_hepatocyte_cell,APOC3,0.68744,0.42993,0.34001,0.54885,literature_grounded_generated
+0.49013,1.03751,0.48662,standard_clinical_surrogate,triantennary_GalNAc,0.0781,0.9219,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0041,5,subcutaneous_context,favorable_long_acting,44,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.79009,0.42645,0.45637,0.47099,literature_grounded_generated
+0.62135,0.89461,0.62145,standard_clinical_surrogate,triantennary_GalNAc,0.27559,0.72441,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0042,2,subcutaneous_context,favorable_long_acting,0,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.79596,0.60957,0.42529,0.48273,literature_grounded_generated
+0.53324,1.02285,0.4369,standard_clinical_surrogate,triantennary_GalNAc,0.21719,0.78281,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0043,3,subcutaneous_context,favorable_long_acting,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.78248,0.50461,0.39964,0.50644,literature_grounded_generated
+0.44,1.2052,0.51202,standard_clinical_surrogate,triantennary_GalNAc,0.13467,0.86533,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0044,3,subcutaneous_context,intermediate,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.73027,0.51663,0.4142,0.5457,literature_grounded_generated
+0.34585,1.06329,0.40411,standard_clinical_surrogate,triantennary_GalNAc,0.14185,0.85815,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0045,3,subcutaneous_context,favorable_long_acting,41,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.76559,0.30156,0.3886,0.54966,literature_grounded_generated
+0.63529,1.14346,0.59631,standard_clinical_surrogate,triantennary_GalNAc,0.32276,0.67724,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0046,3,subcutaneous_context,intermediate,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.79896,0.54508,0.45649,0.492,literature_grounded_generated
+0.71278,1.09588,0.62242,standard_clinical_surrogate,triantennary_GalNAc,0.24875,0.75125,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0047,4,subcutaneous_context,favorable_long_acting,51,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.83821,0.58051,0.44304,0.53196,literature_grounded_generated
+0.53537,1.22837,0.5258,standard_clinical_surrogate,triantennary_GalNAc,0.42306,0.57694,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0048,4,subcutaneous_context,intermediate,29,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.82484,0.56074,0.43199,0.52694,literature_grounded_generated
+0.79416,0.92841,0.69987,reduced_2F_long_acting_lead,triantennary_GalNAc,0.1348,0.8652,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0049,4,subcutaneous_context,favorable_long_acting,42,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.89719,0.54821,0.20031,0.66228,literature_grounded_generated
+0.80286,1.02483,0.74966,reduced_2F_long_acting_lead,triantennary_GalNAc,0.05893,0.94107,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0050,4,subcutaneous_context,favorable_long_acting,0,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.93374,0.56811,0.14968,0.639,literature_grounded_generated
+0.77975,1.10367,0.67676,reduced_2F_long_acting_lead,triantennary_GalNAc,0.18239,0.81761,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0051,2,subcutaneous_context,favorable_long_acting,8,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.89678,0.6363,0.13197,0.6531,literature_grounded_generated
+0.68641,1.16218,0.59422,reduced_2F_long_acting_lead,triantennary_GalNAc,0.08474,0.91526,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0052,4,subcutaneous_context,favorable_long_acting,34,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.90437,0.51136,0.16149,0.63486,literature_grounded_generated
+0.68639,1.04749,0.73539,reduced_2F_long_acting_lead,triantennary_GalNAc,0.08194,0.91806,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0053,5,subcutaneous_context,favorable_long_acting,25,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.92293,0.66546,0.17739,0.61567,literature_grounded_generated
+0.88251,1.0079,0.79204,reduced_2F_long_acting_lead,triantennary_GalNAc,0.17382,0.82618,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0054,3,subcutaneous_context,favorable_long_acting,32,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,1.0,0.57229,0.14902,0.63001,literature_grounded_generated
+0.78283,1.04685,0.70673,reduced_2F_long_acting_lead,triantennary_GalNAc,0.02473,0.97527,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0055,4,subcutaneous_context,favorable_long_acting,17,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.95325,0.62262,0.16881,0.64126,literature_grounded_generated
+0.81889,1.0199,0.76932,reduced_2F_long_acting_lead,triantennary_GalNAc,0.31413,0.68587,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0056,4,subcutaneous_context,intermediate,18,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.96263,0.59796,0.18016,0.66203,literature_grounded_generated
+0.81828,1.14963,0.70521,high_2F_potent_shorter,triantennary_GalNAc,0.45758,0.54242,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0057,2,subcutaneous_context,intermediate,63,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.82104,0.59594,0.55907,0.46272,literature_grounded_generated
+0.79488,1.11231,0.60855,high_2F_potent_shorter,triantennary_GalNAc,0.39382,0.60618,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0058,3,subcutaneous_context,intermediate,62,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.81564,0.56939,0.5523,0.45837,literature_grounded_generated
+0.75701,1.06849,0.66348,high_2F_potent_shorter,triantennary_GalNAc,0.25223,0.74777,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0059,3,subcutaneous_context,favorable_long_acting,55,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.83366,0.51799,0.55484,0.41751,literature_grounded_generated
+0.70543,1.13178,0.61426,high_2F_potent_shorter,triantennary_GalNAc,0.33077,0.66923,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0060,4,subcutaneous_context,intermediate,59,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.88396,0.53484,0.56279,0.42014,literature_grounded_generated
+0.79918,1.04076,0.65831,high_2F_potent_shorter,triantennary_GalNAc,0.29957,0.70043,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0061,2,subcutaneous_context,favorable_long_acting,55,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.77827,0.65745,0.54733,0.4411,literature_grounded_generated
+0.75775,1.13882,0.74236,high_2F_potent_shorter,triantennary_GalNAc,0.2502,0.7498,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0062,5,subcutaneous_context,favorable_long_acting,53,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.80128,0.61539,0.56468,0.46582,literature_grounded_generated
+0.75684,1.18922,0.72516,high_2F_potent_shorter,triantennary_GalNAc,0.34025,0.65975,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0063,5,subcutaneous_context,intermediate,29,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.77538,0.52848,0.60824,0.48356,literature_grounded_generated
+0.69375,1.05465,0.64399,high_2F_potent_shorter,triantennary_GalNAc,0.24607,0.75393,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0064,4,subcutaneous_context,favorable_long_acting,68,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.83491,0.62057,0.49141,0.44926,literature_grounded_generated
+0.70747,1.17643,0.68611,MOE_VP_optimized,triantennary_GalNAc,0.14736,0.85264,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0065,4,subcutaneous_context,favorable_long_acting,43,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.8312,0.6341,0.22683,0.52743,literature_grounded_generated
+0.81377,0.94021,0.81878,MOE_VP_optimized,triantennary_GalNAc,0.11844,0.88156,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0066,4,subcutaneous_context,favorable_long_acting,20,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.9491,0.71207,0.24603,0.60175,literature_grounded_generated
+0.71099,0.92524,0.64841,MOE_VP_optimized,triantennary_GalNAc,0.20792,0.79208,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0067,5,subcutaneous_context,favorable_long_acting,21,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.82207,0.55262,0.23298,0.58691,literature_grounded_generated
+0.84778,1.11669,0.74879,MOE_VP_optimized,triantennary_GalNAc,0.1499,0.8501,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0068,2,subcutaneous_context,favorable_long_acting,29,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.87227,0.682,0.27539,0.56776,literature_grounded_generated
+0.86667,1.17423,0.79486,MOE_VP_optimized,triantennary_GalNAc,0.19787,0.80213,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0069,4,subcutaneous_context,favorable_long_acting,31,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.85374,0.65984,0.24344,0.68362,literature_grounded_generated
+0.74942,1.05993,0.66485,MOE_VP_optimized,triantennary_GalNAc,0.21335,0.78665,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0070,3,subcutaneous_context,favorable_long_acting,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.87038,0.64285,0.25482,0.6069,literature_grounded_generated
+0.73399,1.2878,0.65681,MOE_VP_optimized,triantennary_GalNAc,0.09517,0.90483,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0071,5,subcutaneous_context,intermediate,22,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.74596,0.48049,0.24817,0.59281,literature_grounded_generated
+0.58561,1.08819,0.59153,MOE_VP_optimized,triantennary_GalNAc,0.28905,0.71095,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0072,4,subcutaneous_context,favorable_long_acting,42,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.82782,0.48652,0.23287,0.61932,literature_grounded_generated
+0.45218,1.3446,0.46177,suboptimal_selectivity,triantennary_GalNAc,0.59563,0.40437,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0073,7,subcutaneous_context,selectivity_or_tolerability_concern,38,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.60319,0.37614,0.33757,0.49217,literature_grounded_generated
+0.28654,1.18302,0.27631,suboptimal_selectivity,triantennary_GalNAc,0.54307,0.45693,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0074,7,subcutaneous_context,selectivity_or_tolerability_concern,49,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.54868,0.31635,0.33938,0.56201,literature_grounded_generated
+0.58236,1.2531,0.5707,suboptimal_selectivity,triantennary_GalNAc,0.62005,0.37995,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0075,7,subcutaneous_context,selectivity_or_tolerability_concern,34,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.57935,0.4816,0.35156,0.61425,literature_grounded_generated
+0.48826,1.25327,0.32667,suboptimal_selectivity,triantennary_GalNAc,0.55118,0.44882,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0076,7,subcutaneous_context,selectivity_or_tolerability_concern,50,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.54793,0.43258,0.37936,0.4887,literature_grounded_generated
+0.53213,1.2668,0.57099,suboptimal_selectivity,triantennary_GalNAc,0.41296,0.58704,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0077,6,subcutaneous_context,selectivity_or_tolerability_concern,37,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.59047,0.61127,0.39583,0.55175,literature_grounded_generated
+0.49152,1.2007,0.47405,suboptimal_selectivity,triantennary_GalNAc,0.51274,0.48726,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0078,6,subcutaneous_context,selectivity_or_tolerability_concern,23,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.59732,0.43037,0.3782,0.55356,literature_grounded_generated
+0.46998,1.16817,0.41466,suboptimal_selectivity,triantennary_GalNAc,0.60006,0.39994,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0079,6,subcutaneous_context,selectivity_or_tolerability_concern,14,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.56093,0.407,0.32917,0.5438,literature_grounded_generated
+0.48077,1.43827,0.48222,suboptimal_selectivity,triantennary_GalNAc,0.51451,0.48549,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0080,6,subcutaneous_context,selectivity_or_tolerability_concern,57,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,huAPOC3_mouse,APOC3,0.56684,0.54706,0.31514,0.5531,literature_grounded_generated
+0.47723,1.02069,0.55098,standard_clinical_surrogate,triantennary_GalNAc,0.1226,0.8774,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0081,5,subcutaneous_context,favorable_long_acting,11,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.81086,0.42295,0.43157,0.52784,literature_grounded_generated
+0.56704,1.06849,0.49994,standard_clinical_surrogate,triantennary_GalNAc,0.3885,0.6115,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0082,3,subcutaneous_context,intermediate,4,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.76699,0.50876,0.42234,0.5263,literature_grounded_generated
+0.45596,1.11129,0.52584,standard_clinical_surrogate,triantennary_GalNAc,0.38641,0.61359,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0083,4,subcutaneous_context,intermediate,38,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.84151,0.3922,0.42686,0.47615,literature_grounded_generated
+0.68773,0.9849,0.62307,standard_clinical_surrogate,triantennary_GalNAc,0.30957,0.69043,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0084,6,subcutaneous_context,intermediate,30,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.80822,0.53786,0.36486,0.52,literature_grounded_generated
+0.77312,1.15987,0.61011,standard_clinical_surrogate,triantennary_GalNAc,0.40668,0.59332,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0085,5,subcutaneous_context,intermediate,40,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.86002,0.47507,0.45431,0.5046,literature_grounded_generated
+0.72164,0.97752,0.57439,standard_clinical_surrogate,triantennary_GalNAc,0.40235,0.59765,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0086,4,subcutaneous_context,intermediate,41,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.89136,0.49958,0.42644,0.53404,literature_grounded_generated
+0.53773,1.02139,0.55727,standard_clinical_surrogate,triantennary_GalNAc,0.23795,0.76205,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0087,3,subcutaneous_context,favorable_long_acting,37,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.77331,0.50639,0.39363,0.51126,literature_grounded_generated
+0.58349,1.15086,0.5739,standard_clinical_surrogate,triantennary_GalNAc,0.28826,0.71174,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0088,5,subcutaneous_context,favorable_long_acting,35,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.75229,0.42596,0.42458,0.5542,literature_grounded_generated
+0.8461,1.04734,0.75867,reduced_2F_long_acting_lead,triantennary_GalNAc,0.07901,0.92099,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0089,4,subcutaneous_context,favorable_long_acting,5,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,1.0,0.6443,0.18597,0.58797,literature_grounded_generated
+0.81754,1.11307,0.73074,reduced_2F_long_acting_lead,triantennary_GalNAc,0.13572,0.86428,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0090,4,subcutaneous_context,favorable_long_acting,40,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.92985,0.58023,0.19326,0.60175,literature_grounded_generated
+0.7982,0.94579,0.70059,reduced_2F_long_acting_lead,triantennary_GalNAc,0.02,0.98,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0091,3,subcutaneous_context,favorable_long_acting,10,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.97487,0.64432,0.19007,0.65297,literature_grounded_generated
+0.74666,1.16684,0.74241,reduced_2F_long_acting_lead,triantennary_GalNAc,0.15631,0.84369,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0092,4,subcutaneous_context,favorable_long_acting,5,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.83923,0.66064,0.19911,0.57447,literature_grounded_generated
+0.81962,1.1584,0.72605,reduced_2F_long_acting_lead,triantennary_GalNAc,0.12434,0.87566,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0093,4,subcutaneous_context,favorable_long_acting,48,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,1.0,0.7377,0.15843,0.61439,literature_grounded_generated
+0.79051,1.03933,0.8213,reduced_2F_long_acting_lead,triantennary_GalNAc,0.02,0.98,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0094,2,subcutaneous_context,favorable_long_acting,27,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.95152,0.63373,0.17866,0.5756,literature_grounded_generated
+0.75538,1.19873,0.72257,reduced_2F_long_acting_lead,triantennary_GalNAc,0.06446,0.93554,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0095,2,subcutaneous_context,favorable_long_acting,9,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.86328,0.6037,0.13064,0.65214,literature_grounded_generated
+0.66041,1.0752,0.55838,reduced_2F_long_acting_lead,triantennary_GalNAc,0.08134,0.91866,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0096,5,subcutaneous_context,favorable_long_acting,27,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.97664,0.4522,0.1548,0.60374,literature_grounded_generated
+0.79757,1.07221,0.71165,high_2F_potent_shorter,triantennary_GalNAc,0.30406,0.69594,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0097,3,subcutaneous_context,intermediate,45,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.84215,0.68884,0.58502,0.45082,literature_grounded_generated
+0.58144,1.2762,0.55681,high_2F_potent_shorter,triantennary_GalNAc,0.23406,0.76594,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0098,3,subcutaneous_context,favorable_long_acting,67,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.78619,0.58799,0.50927,0.48155,literature_grounded_generated
+0.80013,1.41091,0.74757,high_2F_potent_shorter,triantennary_GalNAc,0.37647,0.62353,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0099,4,subcutaneous_context,intermediate,52,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.81019,0.62992,0.54947,0.45666,literature_grounded_generated
+0.63545,1.03676,0.55668,high_2F_potent_shorter,triantennary_GalNAc,0.21255,0.78745,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0100,5,subcutaneous_context,favorable_long_acting,55,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.8028,0.55645,0.55876,0.43405,literature_grounded_generated
+0.71135,1.12045,0.58574,high_2F_potent_shorter,triantennary_GalNAc,0.35306,0.64694,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0101,4,subcutaneous_context,intermediate,48,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.84101,0.42936,0.58997,0.48242,literature_grounded_generated
+0.65258,1.14667,0.58919,high_2F_potent_shorter,triantennary_GalNAc,0.28148,0.71852,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0102,3,subcutaneous_context,intermediate,56,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.74187,0.54062,0.53521,0.40158,literature_grounded_generated
+0.72222,1.19384,0.60589,high_2F_potent_shorter,triantennary_GalNAc,0.25892,0.74108,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0103,2,subcutaneous_context,selectivity_or_tolerability_concern,82,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.68484,0.45677,0.59495,0.39067,literature_grounded_generated
+0.67044,1.20677,0.63211,high_2F_potent_shorter,triantennary_GalNAc,0.29069,0.70931,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0104,1,subcutaneous_context,favorable_long_acting,59,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.87312,0.52898,0.56913,0.38221,literature_grounded_generated
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+0.69551,0.99356,0.73725,MOE_VP_optimized,triantennary_GalNAc,0.02,0.98,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0106,3,subcutaneous_context,favorable_long_acting,26,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.92102,0.553,0.24407,0.60605,literature_grounded_generated
+0.66099,1.10613,0.65255,MOE_VP_optimized,triantennary_GalNAc,0.11568,0.88432,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0107,4,subcutaneous_context,favorable_long_acting,7,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.93543,0.54295,0.26528,0.62183,literature_grounded_generated
+0.68864,1.01384,0.60964,MOE_VP_optimized,triantennary_GalNAc,0.08115,0.91885,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0108,2,subcutaneous_context,favorable_long_acting,17,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.86893,0.39717,0.19174,0.57454,literature_grounded_generated
+0.77965,1.13391,0.67929,MOE_VP_optimized,triantennary_GalNAc,0.20519,0.79481,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0109,4,subcutaneous_context,favorable_long_acting,19,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.85109,0.61971,0.19629,0.59534,literature_grounded_generated
+0.89506,1.14244,0.8421,MOE_VP_optimized,triantennary_GalNAc,0.17258,0.82742,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0110,3,subcutaneous_context,favorable_long_acting,43,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.87159,0.72275,0.26502,0.51734,literature_grounded_generated
+0.66385,1.22366,0.6899,MOE_VP_optimized,triantennary_GalNAc,0.17377,0.82623,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0111,5,subcutaneous_context,favorable_long_acting,41,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.96032,0.69058,0.21828,0.59305,literature_grounded_generated
+0.88872,0.97887,0.89343,MOE_VP_optimized,triantennary_GalNAc,0.09926,0.90074,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0112,4,subcutaneous_context,favorable_long_acting,0,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.95087,0.74454,0.17874,0.59643,literature_grounded_generated
+0.47075,1.39618,0.38835,suboptimal_selectivity,triantennary_GalNAc,0.71043,0.28957,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0113,5,subcutaneous_context,intermediate,16,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.65366,0.32466,0.3199,0.55406,literature_grounded_generated
+0.53313,1.09667,0.40745,suboptimal_selectivity,triantennary_GalNAc,0.63449,0.36551,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0114,8,subcutaneous_context,selectivity_or_tolerability_concern,53,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.60137,0.45843,0.3444,0.53096,literature_grounded_generated
+0.48287,1.40076,0.49445,suboptimal_selectivity,triantennary_GalNAc,0.54916,0.45084,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0115,5,subcutaneous_context,selectivity_or_tolerability_concern,58,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.45698,0.40179,0.33992,0.5603,literature_grounded_generated
+0.5341,1.47678,0.48682,suboptimal_selectivity,triantennary_GalNAc,0.49857,0.50143,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0116,5,subcutaneous_context,selectivity_or_tolerability_concern,54,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.62638,0.38322,0.30615,0.58607,literature_grounded_generated
+0.50349,1.45713,0.44101,suboptimal_selectivity,triantennary_GalNAc,0.55317,0.44683,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0117,7,subcutaneous_context,selectivity_or_tolerability_concern,37,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.57103,0.46113,0.33537,0.55843,literature_grounded_generated
+0.368,1.25016,0.41471,suboptimal_selectivity,triantennary_GalNAc,0.57494,0.42506,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0118,6,subcutaneous_context,selectivity_or_tolerability_concern,27,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.58447,0.28905,0.36219,0.49595,literature_grounded_generated
+0.50418,1.31982,0.50179,suboptimal_selectivity,triantennary_GalNAc,0.60776,0.39224,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0119,6,subcutaneous_context,intermediate,45,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.69881,0.48006,0.32712,0.52406,literature_grounded_generated
+0.39302,1.33978,0.49192,suboptimal_selectivity,triantennary_GalNAc,0.46632,0.53368,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0120,7,subcutaneous_context,selectivity_or_tolerability_concern,35,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,CD1_tolerability_mouse,APOC3,0.51234,0.42913,0.31038,0.53539,literature_grounded_generated
+0.51176,1.04267,0.44297,standard_clinical_surrogate,triantennary_GalNAc,0.40145,0.59855,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0121,2,subcutaneous_context,intermediate,31,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.75328,0.5154,0.39698,0.49827,literature_grounded_generated
+0.4883,1.03515,0.46487,standard_clinical_surrogate,triantennary_GalNAc,0.31412,0.68588,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0122,4,subcutaneous_context,intermediate,22,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.79943,0.39941,0.43597,0.49965,literature_grounded_generated
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+0.52707,0.92665,0.60438,standard_clinical_surrogate,triantennary_GalNAc,0.45718,0.54282,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0124,4,subcutaneous_context,intermediate,41,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.82477,0.50436,0.40976,0.51734,literature_grounded_generated
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+0.54831,1.08969,0.46587,standard_clinical_surrogate,triantennary_GalNAc,0.28313,0.71687,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0126,3,subcutaneous_context,favorable_long_acting,23,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.867,0.50201,0.39061,0.49118,literature_grounded_generated
+0.55824,1.10773,0.61423,standard_clinical_surrogate,triantennary_GalNAc,0.2359,0.7641,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0127,3,subcutaneous_context,favorable_long_acting,11,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.80445,0.49577,0.42484,0.51269,literature_grounded_generated
+0.39924,1.27704,0.4542,standard_clinical_surrogate,triantennary_GalNAc,0.41778,0.58222,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0128,4,subcutaneous_context,intermediate,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.7845,0.50478,0.40308,0.49462,literature_grounded_generated
+0.73841,1.15613,0.63422,reduced_2F_long_acting_lead,triantennary_GalNAc,0.25355,0.74645,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0129,2,subcutaneous_context,favorable_long_acting,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.99494,0.51087,0.16588,0.63098,literature_grounded_generated
+0.67388,1.04118,0.63713,reduced_2F_long_acting_lead,triantennary_GalNAc,0.1121,0.8879,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0130,5,subcutaneous_context,favorable_long_acting,15,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.93881,0.57727,0.189,0.66818,literature_grounded_generated
+0.753,1.08581,0.77097,reduced_2F_long_acting_lead,triantennary_GalNAc,0.13715,0.86285,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0131,3,subcutaneous_context,favorable_long_acting,0,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,1.0,0.64065,0.17119,0.63274,literature_grounded_generated
+0.97583,1.06621,0.85739,reduced_2F_long_acting_lead,triantennary_GalNAc,0.16595,0.83405,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0132,2,subcutaneous_context,favorable_long_acting,34,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.845,0.75591,0.12902,0.63055,literature_grounded_generated
+0.85753,1.25994,0.80924,reduced_2F_long_acting_lead,triantennary_GalNAc,0.14669,0.85331,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0133,4,subcutaneous_context,favorable_long_acting,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.85509,0.60426,0.18558,0.60111,literature_grounded_generated
+0.79566,1.05957,0.73452,reduced_2F_long_acting_lead,triantennary_GalNAc,0.1455,0.8545,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0134,4,subcutaneous_context,favorable_long_acting,45,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.91764,0.61728,0.17994,0.57359,literature_grounded_generated
+0.86669,1.12792,0.86419,reduced_2F_long_acting_lead,triantennary_GalNAc,0.0411,0.9589,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0135,4,subcutaneous_context,favorable_long_acting,22,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.95289,0.65556,0.20419,0.62554,literature_grounded_generated
+0.74359,1.00342,0.71964,reduced_2F_long_acting_lead,triantennary_GalNAc,0.02481,0.97519,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0136,3,subcutaneous_context,favorable_long_acting,51,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.88321,0.67107,0.15493,0.63396,literature_grounded_generated
+0.73236,1.05221,0.67147,high_2F_potent_shorter,triantennary_GalNAc,0.3326,0.6674,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0137,4,subcutaneous_context,intermediate,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.93217,0.65728,0.54427,0.45531,literature_grounded_generated
+0.74288,1.07848,0.75221,high_2F_potent_shorter,triantennary_GalNAc,0.33373,0.66627,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0138,2,subcutaneous_context,intermediate,60,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.80242,0.69444,0.5166,0.42749,literature_grounded_generated
+0.62556,0.92931,0.57595,high_2F_potent_shorter,triantennary_GalNAc,0.32372,0.67628,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0139,4,subcutaneous_context,intermediate,58,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.74796,0.55224,0.58808,0.4638,literature_grounded_generated
+0.61765,1.03791,0.57219,high_2F_potent_shorter,triantennary_GalNAc,0.18557,0.81443,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0140,4,subcutaneous_context,favorable_long_acting,55,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.87044,0.5754,0.54527,0.41299,literature_grounded_generated
+0.64367,0.99048,0.53913,high_2F_potent_shorter,triantennary_GalNAc,0.30071,0.69929,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0141,4,subcutaneous_context,intermediate,60,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.79509,0.4642,0.51353,0.45364,literature_grounded_generated
+0.63409,0.90006,0.63579,high_2F_potent_shorter,triantennary_GalNAc,0.42014,0.57986,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0142,4,subcutaneous_context,intermediate,58,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.78871,0.55849,0.57187,0.49436,literature_grounded_generated
+0.78263,0.98173,0.75059,high_2F_potent_shorter,triantennary_GalNAc,0.26623,0.73377,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0143,4,subcutaneous_context,favorable_long_acting,69,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.85699,0.67274,0.6095,0.45921,literature_grounded_generated
+0.73622,1.23375,0.74851,high_2F_potent_shorter,triantennary_GalNAc,0.29011,0.70989,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0144,3,subcutaneous_context,favorable_long_acting,67,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.79602,0.61634,0.56975,0.43784,literature_grounded_generated
+0.77445,1.28699,0.67636,MOE_VP_optimized,triantennary_GalNAc,0.17601,0.82399,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0145,5,subcutaneous_context,favorable_long_acting,12,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.92912,0.48919,0.28465,0.63276,literature_grounded_generated
+0.83154,1.1867,0.67869,MOE_VP_optimized,triantennary_GalNAc,0.26833,0.73167,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0146,1,subcutaneous_context,favorable_long_acting,15,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.81259,0.43534,0.24535,0.60356,literature_grounded_generated
+0.86257,1.06954,0.83095,MOE_VP_optimized,triantennary_GalNAc,0.23563,0.76437,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0147,2,subcutaneous_context,favorable_long_acting,20,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.89935,0.68525,0.22141,0.53485,literature_grounded_generated
+0.70344,1.10926,0.73594,MOE_VP_optimized,triantennary_GalNAc,0.06432,0.93568,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0148,4,subcutaneous_context,favorable_long_acting,4,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.87047,0.69393,0.26022,0.69356,literature_grounded_generated
+0.70337,0.99425,0.62865,MOE_VP_optimized,triantennary_GalNAc,0.25732,0.74268,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0149,2,subcutaneous_context,favorable_long_acting,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.88426,0.49907,0.1864,0.56785,literature_grounded_generated
+0.73974,1.12529,0.64967,MOE_VP_optimized,triantennary_GalNAc,0.07269,0.92731,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0150,2,subcutaneous_context,intermediate,20,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.72453,0.61051,0.23309,0.59192,literature_grounded_generated
+0.76171,1.02498,0.7438,MOE_VP_optimized,triantennary_GalNAc,0.18206,0.81794,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0151,3,subcutaneous_context,favorable_long_acting,18,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.94047,0.60248,0.22737,0.64307,literature_grounded_generated
+0.68507,1.05861,0.68969,MOE_VP_optimized,triantennary_GalNAc,0.16723,0.83277,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0152,5,subcutaneous_context,favorable_long_acting,31,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.86165,0.57166,0.19059,0.58624,literature_grounded_generated
+0.53626,1.36281,0.49328,suboptimal_selectivity,triantennary_GalNAc,0.65481,0.34519,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0153,9,subcutaneous_context,selectivity_or_tolerability_concern,53,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.5919,0.40074,0.34738,0.61124,literature_grounded_generated
+0.55845,1.33636,0.48584,suboptimal_selectivity,triantennary_GalNAc,0.52498,0.47502,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0154,8,subcutaneous_context,selectivity_or_tolerability_concern,70,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.6126,0.5851,0.30633,0.53795,literature_grounded_generated
+0.53196,1.36326,0.51253,suboptimal_selectivity,triantennary_GalNAc,0.5944,0.4056,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0155,8,subcutaneous_context,selectivity_or_tolerability_concern,36,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.54434,0.44125,0.33675,0.5485,literature_grounded_generated
+0.46814,1.22412,0.39737,suboptimal_selectivity,triantennary_GalNAc,0.50261,0.49739,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0156,7,subcutaneous_context,selectivity_or_tolerability_concern,52,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.61639,0.3105,0.35589,0.57723,literature_grounded_generated
+0.39632,1.35942,0.35278,suboptimal_selectivity,triantennary_GalNAc,0.41917,0.58083,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0157,7,subcutaneous_context,selectivity_or_tolerability_concern,46,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.49076,0.44419,0.32861,0.5504,literature_grounded_generated
+0.36726,1.35245,0.34745,suboptimal_selectivity,triantennary_GalNAc,0.68902,0.31098,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0158,7,subcutaneous_context,intermediate,37,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.67625,0.31171,0.37213,0.49289,literature_grounded_generated
+0.4239,1.43415,0.35683,suboptimal_selectivity,triantennary_GalNAc,0.48894,0.51106,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0159,6,subcutaneous_context,selectivity_or_tolerability_concern,60,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.49113,0.31647,0.41203,0.50751,literature_grounded_generated
+0.35964,1.30897,0.48607,suboptimal_selectivity,triantennary_GalNAc,0.41612,0.58388,Ability_to_Solve_Challenge|Potential_Impact|Feasibility_and_Rigor,direct_GalNAc_siRNA_SAR_duration_safety_predictor_module,APOC3_SIRNA_0160,5,subcutaneous_context,selectivity_or_tolerability_concern,33,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,nonhuman_primate,APOC3,0.5691,0.45703,0.33393,0.50624,literature_grounded_generated

evidence/approved_oligo_chemistry_landscape.csv

@@ -0,0 +1,8 @@
+assumption_id,chemistry_or_delivery_feature,clinical_maturity_score_proxy,dataset_context,delivery_specificity_score_proxy,functional_interpretation,generic_safety_complexity_score_proxy,module_id,notes,primary_modality_context,provenance_label,source_id,value_origin
+ASM_125,phosphorothioate_backbone,0.88,broad_ASO_distribution_context,0.8,nuclease_resistance_and_protein_binding,0.7,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",ASO_gapmer_SSO,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,2prime_F_RNA,0.8,approved_siRNA_chemistry_context,0.74,stability_potency_modification,0.58,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",siRNA_aptamer,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,2prime_OMe_RNA,0.82,common_approved_siRNA_modification,0.78,stability_and_immunostimulation_mitigation,0.54,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",siRNA_aptamer,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,2prime_MOE_RNA,0.86,RNase_H_gapmer_or_splice_switching_context,0.76,affinity_stability_second_generation_ASO,0.58,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",ASO_gapmer_SSO,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,PMO,0.72,DMD_splice_switching_context,0.5,neutral_backbone_splice_modulation,0.42,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",splice_switching_oligo,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,LNP,0.84,non_GalNAc_formulated_RNA_delivery_context,0.72,particle_formulation_delivery,0.62,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",siRNA_mRNA,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated
+ASM_125,trivalent_GalNAc,0.92,liver_targeted_subcutaneous_delivery_context,0.94,ASGPR_hepatocyte_targeting,0.48,approved_oligonucleotide_chemistry_delivery_landscape,"Reference row used to standardize chemistry and delivery categories, not to reproduce approved-drug tables.",siRNA_ASO,inferred_from_paper,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,literature_grounded_generated

evidence/aso_gapmer_hepatotoxicity_screening.csv

@@ -0,0 +1,44 @@
+oligo_id,source_id,control_id,target_gene,modality,sequence_length,gc_content,seed_region,hepatotox_score,hepatotoxicity_label,value_origin,assumption_id,aso_gapmer_screen_state,lna_gapmer_screen_context_flag,rnase_h1_gapmer_context_flag,fully_phosphorothioated_gapmer_context_flag,gapmer_length_nt_proxy,acute_mouse_screen_days_proxy,acute_mouse_screen_dose_mg_kg_proxy,repeat_dose_mouse_days_proxy,repeat_dose_rank_concordance_score_proxy,plasma_ALT_fold_vs_control_proxy,plasma_AST_fold_vs_control_proxy,ALT_AST_average_fold_proxy,liver_weight_fold_vs_control_proxy,predicted_offtarget_hit_count_proxy,potent_offtarget_effect_count_proxy,transcriptome_selectivity_score_proxy,mouse_human_OTE_concordance_score_proxy,in_silico_OTE_prediction_required_flag,transcriptome_wide_selectivity_screen_flag,ALT_AST_liver_weight_streamlined_endpoint_flag,positive_negative_control_applicable_flag,hepatotoxicity_screen_rank_label,screening_hepatotoxicity_class_proxy,screening_recommendation,phase2_experimental_design_relevance_score,phase2_translatability_relevance_score,phase2_controls_relevance_score,aso_gapmer_screen_context_confidence_score
+OLIGO_0000019,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,NON_CONTROL_GENERATED_RECORD,CYP2E1,scpBNA2_gapmer_ASO,23,0.5217391304347826,,5.17518697853974,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.735,7.452,4.238,5.845,1.335,286,37,0.617,0.779,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000043,QU_CPG_ODN_APAP_TLR9_IRG1_2025,NON_CONTROL_GENERATED_RECORD,ANGPTL8,scpBNA2_gapmer_ASO,21,0.3333333333333333,,3.7888912187943844,low,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.722,4.395,2.292,3.344,1.154,75,9,0.776,0.91,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.67,0.62,0.7,0.55
+OLIGO_0000133,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,NON_CONTROL_GENERATED_RECORD,PNPLA3,scpBNA2_gapmer_ASO,22,0.45454545454545453,,8.08105735589514,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.753,6.944,4.182,5.563,1.293,463,25,0.648,0.743,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000142,BOSCO_INCLISIRAN_FH_REALWORLD_2025,NON_CONTROL_GENERATED_RECORD,COL1A1,scpBNA2_gapmer_ASO,26,0.5,,6.905249179194064,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.693,6.451,3.87,5.16,1.277,78,8,0.779,0.848,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000154,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,NON_CONTROL_GENERATED_RECORD,PAPD7,scpBNA2_gapmer_ASO,19,0.47368421052631576,,8.958762931609579,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.764,7.399,4.18,5.789,1.336,191,42,0.479,0.725,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000192,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,NON_CONTROL_GENERATED_RECORD,HSD17B13,scpBNA2_gapmer_ASO,23,0.6956521739130435,,7.916632558135945,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.701,6.424,3.727,5.075,1.267,32,2,0.831,0.705,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000212,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,NON_CONTROL_GENERATED_RECORD,APOB,scpBNA2_gapmer_ASO,26,0.34615384615384615,,4.092051726925081,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.706,6.241,3.944,5.092,1.235,154,14,0.761,0.683,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000238,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,NON_CONTROL_GENERATED_RECORD,ANGPTL8,scpBNA2_gapmer_ASO,19,0.631578947368421,,3.234526020647636,low,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.684,5.204,3.075,4.139,1.224,41,7,0.797,0.713,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000267,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,NON_CONTROL_GENERATED_RECORD,FGFR1,scpBNA2_gapmer_ASO,21,0.5714285714285714,,8.766765893454462,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.656,6.24,3.94,5.09,1.334,50,3,0.799,0.94,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000293,KIM_NANP_LIPID_LIVER_TARGETING_2026,NON_CONTROL_GENERATED_RECORD,generic_RNaseH_ASO_target,scpBNA2_gapmer_ASO,27,0.37037037037037035,,3.1098747367575355,low,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.706,3.203,2.537,2.87,1.105,30,5,0.852,0.862,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.67,0.62,0.7,0.55
+OLIGO_0000317,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,NON_CONTROL_GENERATED_RECORD,PCSK9_mouse,scpBNA2_gapmer_ASO,26,0.4230769230769231,,8.093426269558837,high,literature_grounded_generated,ASM_041,generated_background,1,1,1,16,3,100.0,15,0.723,6.624,3.822,5.223,1.274,106,8,0.758,0.87,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000334,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,27,0.4074074074074074,,4.733618290108318,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.714,9.089,4.993,7.041,1.355,490,80,0.295,0.684,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000347,KEATING_ASO_OBESITY_NAFLD_2022,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,27,0.48148148148148145,,10.0,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.665,6.831,4.041,5.436,1.297,82,11,0.765,0.719,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000348,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,NON_CONTROL_GENERATED_RECORD,AHSA1,scpBNA2_gapmer_ASO,24,0.5833333333333334,,4.437785192011007,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.676,4.964,3.12,4.042,1.201,35,7,0.787,0.691,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.67,0.62,0.7,0.55
+OLIGO_0000376,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_2018,NON_CONTROL_GENERATED_RECORD,CEBPB,scpBNA2_gapmer_ASO,24,0.4166666666666667,,5.0519490634619215,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.719,5.423,3.372,4.397,1.166,42,8,0.844,0.913,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000473,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,26,0.38461538461538464,,6.667264642618774,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.696,6.324,3.262,4.793,1.191,86,8,0.834,0.831,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000486,XI_HCC_CHROMATIN_DGAT1_SIRNA_2025,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,26,0.5384615384615384,,6.25488560323628,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.733,6.78,3.975,5.378,1.298,184,20,0.696,0.739,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000508,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,NON_CONTROL_GENERATED_RECORD,generic_RNaseH_ASO_target,scpBNA2_gapmer_ASO,21,0.42857142857142855,,7.249194412713245,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.702,8.339,4.948,6.644,1.354,464,74,0.32,0.642,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000514,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,26,0.5,,8.690758710700003,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.673,8.206,4.761,6.483,1.321,224,35,0.57,0.752,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000520,SUBRAMANIAN_RNAI_RHEOSTAT_AAV_TRANSGENE_2023,NON_CONTROL_GENERATED_RECORD,HSD17B13,scpBNA2_gapmer_ASO,21,0.42857142857142855,,7.793908792647904,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.658,7.2,4.081,5.64,1.369,218,25,0.743,0.875,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000575,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,NON_CONTROL_GENERATED_RECORD,MOGAT1,scpBNA2_gapmer_ASO,19,0.5263157894736842,,3.89355063407543,low,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.73,7.27,3.67,5.47,1.258,120,19,0.659,0.718,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000590,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,NON_CONTROL_GENERATED_RECORD,PCDHA11,scpBNA2_gapmer_ASO,22,0.5909090909090909,,6.8849433964516065,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.685,6.936,3.865,5.401,1.272,153,18,0.647,0.848,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000616,JIANG_LNP_CRISPR_HAO1_PH1_2025,NON_CONTROL_GENERATED_RECORD,HSD17B13,scpBNA2_gapmer_ASO,25,0.4,,7.860847489645764,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.684,6.231,3.986,5.108,1.293,65,9,0.75,0.877,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000620,JIANG_LNP_CRISPR_HAO1_PH1_2025,NON_CONTROL_GENERATED_RECORD,PNPLA3,scpBNA2_gapmer_ASO,23,0.43478260869565216,,6.264893318231828,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.75,6.155,3.824,4.989,1.308,76,7,0.797,0.638,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000629,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,NON_CONTROL_GENERATED_RECORD,generic_RNaseH_ASO_target,scpBNA2_gapmer_ASO,19,0.5789473684210527,,9.071726529667577,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.662,6.623,4.077,5.35,1.304,136,15,0.702,0.679,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000691,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,NON_CONTROL_GENERATED_RECORD,G0S2,scpBNA2_gapmer_ASO,21,0.5238095238095238,,3.408713284750292,low,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.713,4.201,2.805,3.503,1.17,33,5,0.893,0.691,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.67,0.62,0.7,0.55
+OLIGO_0000756,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,NON_CONTROL_GENERATED_RECORD,PCDHA11,scpBNA2_gapmer_ASO,24,0.4166666666666667,,7.557395884081357,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,15,3,100.0,15,0.689,7.152,4.047,5.6,1.303,102,14,0.637,0.628,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000769,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,NON_CONTROL_GENERATED_RECORD,generic_offtarget,scpBNA2_gapmer_ASO,21,0.5238095238095238,,7.62602746330793,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.745,6.973,3.532,5.252,1.409,115,8,0.791,0.812,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000935,HJELMGREN_PS_ASO_DDR_2026,NON_CONTROL_GENERATED_RECORD,NANP_delivery_benchmark,scpBNA2_gapmer_ASO,25,0.48,,8.609913951363525,high,literature_grounded_generated,ASM_043,generated_background,1,1,1,16,3,100.0,15,0.755,6.243,4.044,5.144,1.235,36,3,0.754,0.953,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000940,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,NON_CONTROL_GENERATED_RECORD,NR3C1,scpBNA2_gapmer_ASO,24,0.5416666666666666,,9.710685662536065,high,literature_grounded_generated,ASM_002,generated_background,1,1,1,16,3,100.0,15,0.717,6.097,3.792,4.944,1.259,51,6,0.775,0.866,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000973,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,NON_CONTROL_GENERATED_RECORD,PAPD5,scpBNA2_gapmer_ASO,24,0.4166666666666667,,6.247259933981451,moderate,literature_grounded_generated,ASM_002,generated_background,1,1,1,14,3,100.0,15,0.706,7.54,4.219,5.88,1.329,189,32,0.606,0.775,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_0000976,RAPIROSIRAN_SANYAL_2025,NON_CONTROL_GENERATED_RECORD,RUBICON,scpBNA2_gapmer_ASO,23,0.43478260869565216,,8.304047869783435,high,literature_grounded_generated,ASM_018,generated_background,1,1,1,14,3,100.0,15,0.664,7.43,3.947,5.688,1.307,297,29,0.622,0.6,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.67,0.62,0.7,0.55
+OLIGO_CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK,sequence_motif_liver_risk,LNA_cEt_PS_gapmer_ASO,18,0.7777777777777778,CGCGUUG,8.4,high,literature_grounded_generated_control,ASM_032,generated_background,1,1,1,14,3,100.0,15,0.916,7.062,4.289,5.675,1.34,336,32,0.543,0.656,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.94,0.91,0.95,0.9
+OLIGO_CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,BACH1_PAR2_like_offtarget_context,LNA gapmer ASO,14,0.35714285714285715,CUAUCUU,8.6,high,literature_grounded_generated_control,ASM_038,encoded,1,1,1,14,3,100.0,15,0.963,18.0,8.5,13.25,1.34,560,118,0.18,0.624,1,1,1,1,high_OTE_high_ALT_AST_positive_control,high,deselect_or_redesign,0.94,0.91,0.95,0.9
+OLIGO_CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX,BACH1_like_selective_context,LNA gapmer ASO,16,0.375,ACGUAAA,1.4,low,literature_grounded_generated_control,ASM_038,encoded,1,1,1,16,3,30.0,15,0.959,1.05,0.98,1.015,1.02,18,2,0.91,0.82,1,1,1,1,selective_low_ALT_AST_negative_control,low,progress_with_standard_safety_followup,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN,screening_endpoint_context,LNA gapmer ASO,16,0.375,AUCACAU,4.5,moderate,literature_grounded_generated_control,ASM_038,encoded,1,1,1,16,3,100.0,15,0.886,1.8,1.4,1.6,1.2,160,35,0.63,0.874,1,1,1,1,acute_screen_context,context,rank_by_ALT_AST_liver_weight_then_confirm,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY,offtarget_selectivity_context,LNA gapmer ASO,14,0.7142857142857143,UCUAGCG,5.1,moderate,literature_grounded_generated_control,ASM_038,encoded,1,1,1,14,3,100.0,15,0.903,3.2,1.9,2.55,1.21,220,55,0.54,0.684,1,1,1,1,transcriptome_selectivity_context,context,integrate_in_silico_and_RNAseq_selectivity,0.94,0.91,0.95,0.9
+OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,AGO1,LNP-delivered LNA gapmer ASO,16,0.5,UGCUCUU,1.6,low,literature_grounded_generated_control,ASM_039,generated_background,1,1,1,14,3,100.0,15,0.961,4.647,2.791,3.719,1.167,91,8,0.739,0.662,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,AGO1_NFKB_context,LNA gapmer ASO mechanism context,16,0.5,GCUUCAU,3.8,low,literature_grounded_generated_control,ASM_039,generated_background,1,1,1,14,3,100.0,15,0.915,6.148,3.664,4.906,1.238,104,9,0.828,0.691,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,AGO1,LNP-delivered LNA gapmer ASO,16,0.4375,CUAUGGC,2.4,low,literature_grounded_generated_control,ASM_039,generated_background,1,1,1,16,3,100.0,15,0.919,2.621,2.093,2.357,1.082,17,1,0.952,0.897,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,AGO1_paracrine_context,LNA gapmer ASO cell-interaction context,16,0.5625,CCGGGUU,3.0,low,literature_grounded_generated_control,ASM_039,generated_background,1,1,1,14,3,100.0,15,0.959,6.665,3.783,5.224,1.28,267,18,0.722,0.719,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.94,0.91,0.95,0.9
+OLIGO_CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION,GYS1,PS-cEt RNase-H1 gapmer ASO,16,0.375,UGCUUGA,1.1,low,literature_grounded_generated_control,ASM_040,generated_background,1,1,1,16,3,100.0,15,0.952,2.205,1.679,1.942,1.093,21,2,0.955,0.859,1,1,1,1,intermediate_screen_signal,moderate,redesign_or_follow_with_RNAseq_selectivity,0.94,0.91,0.95,0.9
+OLIGO_CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE,GYS1,PS-cEt RNase-H1 gapmer ASO,16,0.375,AAUACGA,2.3,low,literature_grounded_generated_control,ASM_040,generated_background,1,1,1,14,3,100.0,15,0.934,6.545,3.869,5.207,1.268,101,19,0.683,0.683,1,1,1,1,high_OTE_hepatotoxicity_like,high,deselect_or_redesign,0.94,0.91,0.95,0.9

evidence/aso_late_onset_neurotox_chemical_modifications.csv

@@ -0,0 +1,7 @@
+PS_protein_binding_stress_score_proxy,assumption_id,challenge_alignment,chemical_modification_context,late_onset_neurotoxicity_score_proxy,liver_oligotox_relevance,model_system,modeling_role,module_id,notes,oligo_modality,p53_regulated_transcript_stress_score_proxy,paraspeckle_p54nrb_mislocalization_score_proxy,provenance_label,scenario_id,source_id,target_knockdown_preservation_score_proxy,value_origin
+0.7,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,none,0.82,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,mouse_i_c_v_or_rat_i_t,toxic_parent_reference,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.78,0.75,inferred_from_paper,parent_gapmer_ASO_late_toxic,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.35,literature_grounded_generated
+0.15,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,clinical_like_reference,0.12,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,CNS_reference,non_toxic_reference,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.18,0.16,inferred_from_paper,non_toxic_reference_ASO5,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.6,literature_grounded_generated
+0.3,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,2prime-OMe_gap_position_2,0.38,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,in_vitro_and_in_vivo,toxicity_reduction_candidate,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.35,0.32,inferred_from_paper,2prime_OMe_position_2,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.55,literature_grounded_generated
+0.6,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,2prime-OMe_unfavorable_gap_position,0.7,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,in_vitro,structure_toxicity_warning,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.68,0.62,inferred_from_paper,2prime_OMe_unfavorable_positions,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.4,literature_grounded_generated
+0.24,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,5prime-cyclopropylene_site_specific,0.24,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,in_vitro_and_in_vivo,optimized_chemical_mitigation,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.26,0.22,inferred_from_paper,5prime_CP_protective_position,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.7,literature_grounded_generated
+0.72,ASM_081,supports feasibility and rigor by encoding ASO structure-toxicity rules and toxicity-mitigating chemistry that can inform general oligo safety feature design,protein_binding_stress_mechanism,0.76,cross_organ_ASO_toxicity_and_chemistry_mitigation_feature_engineering,neuronal_cells,mechanistic_toxicity_axis,ASO_late_onset_neurotoxicity_chemical_modification,"Generated cross-organ toxicity scenario row; not a liver module, but useful for oligo chemistry safety modeling.",gapmer_PS_ASO,0.72,0.78,inferred_from_paper,paraspeckle_mislocalization_mechanism,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIFICATIONS_2025,0.3,literature_grounded_generated

evidence/aso_multiomics_time_resolved_safety.csv

@@ -0,0 +1,37 @@
+HepG2_apoptosis_or_cell_stress_score_proxy,aso_profile_id,challenge_alignment,chemistry_design,intended_on_target_transcript,modeling_role,module_id,mouse_ALT_IU_per_L_proxy,notes,pathway_perturbation_score_proxy,protein_level_offtarget_burden_score_proxy,proteomics_de_risking_relevance,provenance_label,rna_level_offtarget_burden_score_proxy,rna_protein_offtarget_discordance_score_proxy,safety_assessment_layer,source_id,timepoint_hours,toxicity_class,value_origin
+0.009,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.012,0.009,moderate_or_low,inferred_from_paper,0.016,0.006,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,non_toxic_reference,literature_grounded_generated
+0.016,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.021,0.016,moderate_or_low,inferred_from_paper,0.027,0.011,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,non_toxic_reference,literature_grounded_generated
+0.019,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.026,0.019,moderate_or_low,inferred_from_paper,0.032,0.013,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,non_toxic_reference,literature_grounded_generated
+0.026,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.035,0.026,moderate_or_low,inferred_from_paper,0.043,0.017,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,non_toxic_reference,literature_grounded_generated
+0.029,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.039,0.029,moderate_or_low,inferred_from_paper,0.049,0.02,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,non_toxic_reference,literature_grounded_generated
+0.03,vehicle_PBS,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,vehicle,none,baseline_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.04,0.03,moderate_or_low,inferred_from_paper,0.05,0.02,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,non_toxic_reference,literature_grounded_generated
+0.025,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.034,0.031,moderate_or_low,inferred_from_paper,0.056,0.019,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,non_toxic,literature_grounded_generated
+0.043,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.059,0.053,moderate_or_low,inferred_from_paper,0.096,0.032,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,non_toxic,literature_grounded_generated
+0.052,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.071,0.064,moderate_or_low,inferred_from_paper,0.116,0.039,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,non_toxic,literature_grounded_generated
+0.069,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.095,0.087,moderate_or_low,inferred_from_paper,0.156,0.052,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,non_toxic,literature_grounded_generated
+0.078,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.108,0.098,moderate_or_low,inferred_from_paper,0.176,0.059,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,non_toxic,literature_grounded_generated
+0.08,569713,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,none_control_ASO,non_toxic_ASO_control,ASO_time_resolved_multiomics_safety,31,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.11,0.1,moderate_or_low,inferred_from_paper,0.18,0.06,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,non_toxic,literature_grounded_generated
+0.028,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.037,0.04,moderate_or_low,inferred_from_paper,0.068,0.022,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,non_toxic,literature_grounded_generated
+0.048,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.064,0.069,moderate_or_low,inferred_from_paper,0.117,0.037,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,non_toxic,literature_grounded_generated
+0.058,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.077,0.084,moderate_or_low,inferred_from_paper,0.142,0.045,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,non_toxic,literature_grounded_generated
+0.078,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.104,0.113,moderate_or_low,inferred_from_paper,0.191,0.061,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,non_toxic,literature_grounded_generated
+0.088,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.117,0.127,moderate_or_low,inferred_from_paper,0.215,0.068,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,non_toxic,literature_grounded_generated
+0.09,LNA32,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mMYD88,non_toxic_targeting_ASO,ASO_time_resolved_multiomics_safety,29,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.12,0.13,moderate_or_low,inferred_from_paper,0.22,0.07,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,non_toxic,literature_grounded_generated
+0.078,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.121,0.106,high,inferred_from_paper,0.168,0.068,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,medium_liver_toxic,literature_grounded_generated
+0.133,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.208,0.181,high,inferred_from_paper,0.288,0.117,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,medium_liver_toxic,literature_grounded_generated
+0.161,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.251,0.219,high,inferred_from_paper,0.348,0.142,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,medium_liver_toxic,literature_grounded_generated
+0.217,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.338,0.295,high,inferred_from_paper,0.468,0.191,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,medium_liver_toxic,literature_grounded_generated
+0.244,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.381,0.332,high,inferred_from_paper,0.528,0.215,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,medium_liver_toxic,literature_grounded_generated
+0.25,SPC5001,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,hPCSK9,moderate_toxicity_profile,ASO_time_resolved_multiomics_safety,159,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.39,0.34,high,inferred_from_paper,0.54,0.22,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,medium_liver_toxic,literature_grounded_generated
+0.134,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.268,0.243,high,inferred_from_paper,0.283,0.128,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,liver_toxic,literature_grounded_generated
+0.229,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.459,0.416,high,inferred_from_paper,0.485,0.219,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,liver_toxic,literature_grounded_generated
+0.277,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.554,0.503,high,inferred_from_paper,0.586,0.264,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,liver_toxic,literature_grounded_generated
+0.373,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.745,0.676,high,inferred_from_paper,0.789,0.355,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,liver_toxic,literature_grounded_generated
+0.42,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.841,0.763,high,inferred_from_paper,0.89,0.401,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,liver_toxic,literature_grounded_generated
+0.43,569720,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-10-3_PS_gapmer,mFXI,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.86,0.78,high,inferred_from_paper,0.91,0.41,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,liver_toxic,literature_grounded_generated
+0.146,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.277,0.255,high,inferred_from_paper,0.292,0.134,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,8,liver_toxic,literature_grounded_generated
+0.251,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.475,0.437,high,inferred_from_paper,0.501,0.229,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,24,liver_toxic,literature_grounded_generated
+0.303,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.574,0.528,high,inferred_from_paper,0.606,0.277,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,32,liver_toxic,literature_grounded_generated
+0.407,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.771,0.711,high,inferred_from_paper,0.815,0.373,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,48,liver_toxic,literature_grounded_generated
+0.46,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.87,0.802,high,inferred_from_paper,0.919,0.42,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,56,liver_toxic,literature_grounded_generated
+0.47,LNA43,directly supports feasibility/rigor by modeling ASO toxicity assessment across RNA and protein layers,LNA_3-8-3_PS_gapmer,mMYD88,severe_toxicity_profile,ASO_time_resolved_multiomics_safety,10000,Generated time-course row; proxy values encode reported qualitative/relative safety concepts without reproducing source tables.,0.89,0.82,high,inferred_from_paper,0.94,0.43,RNAseq|global_proteomics|qPCR|western_blot|HepG2|mouse_ALT,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED_SAFETY_2026,72,liver_toxic,literature_grounded_generated

evidence/bepirovirsen_immunomodulation_alt.csv

@@ -0,0 +1,7 @@
+ALT_increase_association_score_proxy,HBsAg_decline_response_score_proxy,apoptosis_liver_specific_protein_score_proxy,challenge_alignment,clinical_biomarker_layers,direct_antiviral_HBV_RNA_targeting,disease_context,immune_cell_transcript_activation_score_proxy,immune_effector_activation_score_proxy,module_id,notes,oligo_modality,provenance_label,scenario_id,source_id,therapeutic_ALT_interpretation,time_context,value_origin,week_on_bepirovirsen_proxy
+0.05,0.05,0.08,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.1,0.12,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,baseline_NA_background,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,low_or_baseline_ALT_context,pre_dose,literature_grounded_generated,0
+0.18,0.21,0.34,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.46,0.72,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,week3_effector_apoptotic_serum_proteins,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,low_or_baseline_ALT_context,week_3,literature_grounded_generated,3
+0.25,0.3,0.39,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.64,0.66,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,week5_immune_cell_activation_transcripts,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,low_or_baseline_ALT_context,week_5,literature_grounded_generated,5
+0.68,0.76,0.79,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.83,0.86,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,week8_liver_apoptosis_proteins_responder,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,possible_infected_hepatocyte_killing_signal,week_8_responder,literature_grounded_generated,8
+0.32,0.26,0.31,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.38,0.48,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,week8_liver_apoptosis_proteins_nonresponder,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,low_or_baseline_ALT_context,week_8_nonresponder,literature_grounded_generated,8
+0.72,0.81,0.73,"directly strengthens Ability-to-Solve, Potential-Impact, and Feasibility/Rigor by representing clinical ASO ALT-response biology",serum_proteomics|whole_blood_transcriptomics|PBMC_immunophenotyping_context,yes_all_HBV_RNAs,chronic_HBV_on_stable_nucleoside_analog_background,0.78,0.82,bepirovirsen_ASO_immunomodulation_ALT_context,Generated clinical-biomarker scenario row; no patient-level data or source tables reproduced.,unconjugated_ASO,inferred_from_paper,HBsAg_decline_with_transient_ALT_and_HBV_DNA,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODULATION_2026,possible_infected_hepatocyte_killing_signal,on_treatment_responder_pattern,literature_grounded_generated,8

evidence/biologics_hyb_targeted_rna_delivery.csv

@@ -0,0 +1,8 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.58,0.62,EMNV,cell_derived_nanovesicles,biological_nanoparticle_baseline,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.64,inferred_from_paper,EMNV_baseline_biological_nanovesicle,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.14,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.74,0.78,hybrid_EMNV_liposome,extruded_Hyb_nanoparticles,RNA_loading_and_fusion_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.86,inferred_from_paper,Hyb_extrusion_fusion_RNA_loading,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.18,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.76,0.72,hybrid_EMNV_liposome,HepG2_and_mouse_cell_lines,intracellular_RNA_delivery_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.88,inferred_from_paper,FAM_RNA_intracellular_delivery,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.2,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.8,0.74,EMNV_surface_engineering,genetic_targeting_platform,targeting_display_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.72,inferred_from_paper,DCD63_surface_display,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.18,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.86,0.8,EMNV_surface_engineering,genetic_targeting_platform,high_efficiency_targeting_display_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.78,inferred_from_paper,PTGFRN_surface_display,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.18,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.86,0.82,liver_targeted_Hyb_siRNA,in_vitro_in_vivo_liver_targeting,liver_targeted_siRNA_delivery_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.84,inferred_from_paper,liver_targeted_Hyb_siRNA,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.22,literature_grounded_generated
+ASM_103,"supporting module for oligo modality, delivery, specificity, biodistribution, tolerability, and model-readiness; not direct hepatotoxicity evidence unless explicitly labeled",0.7,0.76,hybrid_EMNV_liposome,lysosome_colocalization_stability,endosomal_lysosomal_trafficking_context,biologics_Hyb_EMNV_liposome_RNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.72,inferred_from_paper,lysosome_escape_stability_context,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_DELIVERY_2025,0.18,literature_grounded_generated

evidence/brothers_aso_pna_toxicity_mitigation.csv

@@ -0,0 +1,121 @@
+alt_fold_uln_proxy,aso_type,body_weight_fraction_baseline_proxy,design_class,dose_nmol_per_kg,duplex_tm_celsius_proxy,ed50_nmol_per_kg_context_proxy,judging_alignment,modeling_value,module_record_id,pcsk9_knockdown_fraction_proxy,pna_brother_strand_length_nt,protein_binding_score_proxy,rna_offtarget_hybridization_score_proxy,safety_class_generated,source_id,therapeutic_margin_score_proxy,toehold_domain_present,toehold_mismatch_discrimination_score_proxy,value_origin
+2.86136,GalNAc_LNA_gapmer_ASO,0.93419,parent_mPCS1_ssASO,25,-0.5003,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0001,0.60552,0,0.60402,0.77649,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.20799,0,0.22351,literature_grounded_generated
+2.8546,GalNAc_LNA_gapmer_ASO,0.95447,parent_mPCS1_ssASO,25,3.12249,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0002,0.54928,0,0.66532,0.76773,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.1891,0,0.23227,literature_grounded_generated
+2.86853,GalNAc_LNA_gapmer_ASO,0.95169,parent_mPCS1_ssASO,25,-0.42215,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0003,0.55674,0,0.60084,0.72702,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.19076,0,0.27298,literature_grounded_generated
+2.64478,GalNAc_LNA_gapmer_ASO,0.95034,parent_mPCS1_ssASO,25,-1.6172,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0004,0.56188,0,0.67415,0.78411,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.20851,0,0.21589,literature_grounded_generated
+0.61251,ASO_PNA_BRO_duplex,1.00254,BRO_PNA12_high_Tm,25,79.71641,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0005,0.22434,12,0.19106,0.30042,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.33862,1,0.69958,literature_grounded_generated
+0.66333,ASO_PNA_BRO_duplex,1.0035,BRO_PNA12_high_Tm,25,78.85719,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0006,0.21409,12,0.18541,0.29935,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.30013,1,0.70065,literature_grounded_generated
+0.58712,ASO_PNA_BRO_duplex,0.98818,BRO_PNA12_high_Tm,25,79.40745,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0007,0.19861,12,0.21116,0.27753,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.31173,1,0.72247,literature_grounded_generated
+0.63674,ASO_PNA_BRO_duplex,0.99319,BRO_PNA12_high_Tm,25,78.81042,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0008,0.20226,12,0.22764,0.24673,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.29452,1,0.75327,literature_grounded_generated
+0.73144,ASO_PNA_BRO_duplex,1.00829,BRO_PNA11_high_Tm,25,73.08398,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0009,0.31196,11,0.21607,0.32411,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.39922,1,0.67589,literature_grounded_generated
+0.69591,ASO_PNA_BRO_duplex,0.99941,BRO_PNA11_high_Tm,25,73.12316,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0010,0.26691,11,0.23953,0.32049,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.35784,1,0.67951,literature_grounded_generated
+0.78601,ASO_PNA_BRO_duplex,0.99782,BRO_PNA11_high_Tm,25,72.85178,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0011,0.24089,11,0.26525,0.31613,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.28815,1,0.68387,literature_grounded_generated
+0.66838,ASO_PNA_BRO_duplex,0.98406,BRO_PNA11_high_Tm,25,75.33384,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0012,0.29239,11,0.23896,0.32935,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.40701,1,0.67065,literature_grounded_generated
+0.61956,ASO_PNA_BRO_duplex,0.9784,BRO_PNA10_balanced,25,62.08113,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0013,0.47192,10,0.29164,0.30854,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.70482,1,0.69146,literature_grounded_generated
+0.67623,ASO_PNA_BRO_duplex,0.99083,BRO_PNA10_balanced,25,61.68327,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0014,0.42673,10,0.26292,0.40362,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.58759,1,0.59638,literature_grounded_generated
+0.6943,ASO_PNA_BRO_duplex,1.00264,BRO_PNA10_balanced,25,61.67368,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0015,0.36122,10,0.30882,0.29963,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.48531,1,0.70037,literature_grounded_generated
+0.79587,ASO_PNA_BRO_duplex,0.98165,BRO_PNA10_balanced,25,63.41687,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0016,0.49272,10,0.27167,0.43215,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.5825,1,0.56785,literature_grounded_generated
+0.62859,ASO_PNA_BRO_duplex,0.99372,BRO_PNA_C8_optimized,25,59.03886,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0017,0.59392,8,0.35578,0.35458,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.87523,1,0.64542,literature_grounded_generated
+0.67016,ASO_PNA_BRO_duplex,1.00556,BRO_PNA_C8_optimized,25,59.11365,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0018,0.51938,8,0.43981,0.41843,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.7212,1,0.58157,literature_grounded_generated
+0.60028,ASO_PNA_BRO_duplex,0.97834,BRO_PNA_C8_optimized,25,59.0532,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0019,0.51064,8,0.31992,0.4224,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.78527,1,0.5776,literature_grounded_generated
+0.77324,ASO_PNA_BRO_duplex,1.01192,BRO_PNA_C8_optimized,25,59.13572,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0020,0.54177,8,0.327,0.40933,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.6581,1,0.59067,literature_grounded_generated
+1.28014,ASO_PNA_BRO_duplex,1.0027,cRNA_duplex_context,25,63.00665,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0021,0.39884,14,0.50667,0.47213,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.29985,0,0.52787,literature_grounded_generated
+1.1178,ASO_PNA_BRO_duplex,0.98194,cRNA_duplex_context,25,61.74386,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0022,0.40394,14,0.34067,0.47019,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.3459,0,0.52981,literature_grounded_generated
+1.23112,ASO_PNA_BRO_duplex,0.99356,cRNA_duplex_context,25,62.60679,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0023,0.36759,14,0.41714,0.41321,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.28693,0,0.58679,literature_grounded_generated
+1.23523,ASO_PNA_BRO_duplex,0.99905,cRNA_duplex_context,25,61.45976,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0024,0.36103,14,0.51834,0.48856,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.28091,0,0.51144,literature_grounded_generated
+3.07832,GalNAc_LNA_gapmer_ASO,0.95615,parent_mPCS1_ssASO,50,-1.04496,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0025,0.64474,0,0.62254,0.79228,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.2061,0,0.20772,literature_grounded_generated
+3.13667,GalNAc_LNA_gapmer_ASO,0.95393,parent_mPCS1_ssASO,50,0.81609,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0026,0.66492,0,0.57497,0.81568,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.20866,0,0.18432,literature_grounded_generated
+2.88337,GalNAc_LNA_gapmer_ASO,0.9404,parent_mPCS1_ssASO,50,0.88917,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0027,0.68269,0,0.68531,0.76858,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.23273,0,0.23142,literature_grounded_generated
+2.87139,GalNAc_LNA_gapmer_ASO,0.9479,parent_mPCS1_ssASO,50,-1.39569,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0028,0.62155,0,0.61536,0.86404,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.21276,0,0.13596,literature_grounded_generated
+0.67887,ASO_PNA_BRO_duplex,1.00266,BRO_PNA12_high_Tm,50,78.24086,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0029,0.19005,12,0.25794,0.20869,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.26075,1,0.79131,literature_grounded_generated
+0.67704,ASO_PNA_BRO_duplex,0.99345,BRO_PNA12_high_Tm,50,80.80612,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0030,0.17882,12,0.18349,0.20044,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.24596,1,0.79956,literature_grounded_generated
+0.73416,ASO_PNA_BRO_duplex,1.00371,BRO_PNA12_high_Tm,50,79.01023,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0031,0.20534,12,0.18231,0.26802,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.26186,1,0.73198,literature_grounded_generated
+0.75841,ASO_PNA_BRO_duplex,1.00765,BRO_PNA12_high_Tm,50,78.13764,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0032,0.25887,12,0.1735,0.32629,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.32022,1,0.67371,literature_grounded_generated
+0.70836,ASO_PNA_BRO_duplex,1.00419,BRO_PNA11_high_Tm,50,74.55371,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0033,0.33829,11,0.25421,0.32779,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.44609,1,0.67221,literature_grounded_generated
+0.6083,ASO_PNA_BRO_duplex,0.98458,BRO_PNA11_high_Tm,50,73.49252,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0034,0.33146,11,0.27589,0.35443,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.5035,1,0.64557,literature_grounded_generated
+0.76514,ASO_PNA_BRO_duplex,0.99288,BRO_PNA11_high_Tm,50,73.44297,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0035,0.27241,11,0.25239,0.40425,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.33418,1,0.59575,literature_grounded_generated
+0.67183,ASO_PNA_BRO_duplex,0.98959,BRO_PNA11_high_Tm,50,74.72512,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0036,0.28775,11,0.28346,0.37925,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.39865,1,0.62075,literature_grounded_generated
+0.72643,ASO_PNA_BRO_duplex,0.98518,BRO_PNA10_balanced,50,62.72867,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0037,0.52299,10,0.28702,0.38978,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.67359,1,0.61022,literature_grounded_generated
+0.61967,ASO_PNA_BRO_duplex,0.99745,BRO_PNA10_balanced,50,62.8609,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0038,0.40398,10,0.32742,0.32055,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.60324,1,0.67945,literature_grounded_generated
+0.60912,ASO_PNA_BRO_duplex,0.99948,BRO_PNA10_balanced,50,60.83577,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0039,0.44399,10,0.28693,0.32268,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.6736,1,0.67732,literature_grounded_generated
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+0.71853,ASO_PNA_BRO_duplex,0.99752,BRO_PNA11_high_Tm,200,75.68662,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0084,0.34324,11,0.31062,0.33246,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.44662,1,0.66754,literature_grounded_generated
+0.71271,ASO_PNA_BRO_duplex,1.00048,BRO_PNA10_balanced,200,62.91751,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0085,0.47692,10,0.30793,0.41915,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.62529,1,0.58085,literature_grounded_generated
+0.77582,ASO_PNA_BRO_duplex,1.00348,BRO_PNA10_balanced,200,63.60292,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0086,0.5069,10,0.30654,0.44181,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.61382,1,0.55819,literature_grounded_generated
+0.69546,ASO_PNA_BRO_duplex,0.98791,BRO_PNA10_balanced,200,62.23077,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0087,0.49201,10,0.28314,0.28856,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.66,1,0.71144,literature_grounded_generated
+0.71109,ASO_PNA_BRO_duplex,0.99666,BRO_PNA10_balanced,200,62.69109,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0088,0.50871,10,0.2582,0.29888,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.6684,1,0.70112,literature_grounded_generated
+0.7406,ASO_PNA_BRO_duplex,0.97687,BRO_PNA_C8_optimized,200,59.79071,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0089,0.66082,8,0.40228,0.30146,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.83584,1,0.69854,literature_grounded_generated
+0.6741,ASO_PNA_BRO_duplex,0.9826,BRO_PNA_C8_optimized,200,59.71893,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0090,0.66741,8,0.3201,0.43952,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.92172,1,0.56048,literature_grounded_generated
+0.68101,ASO_PNA_BRO_duplex,0.98583,BRO_PNA_C8_optimized,200,59.84367,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0091,0.59554,8,0.35275,0.35999,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.81468,1,0.64001,literature_grounded_generated
+0.74812,ASO_PNA_BRO_duplex,1.00179,BRO_PNA_C8_optimized,200,60.64029,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0092,0.71467,8,0.28809,0.34469,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.89544,1,0.65531,literature_grounded_generated
+1.39484,ASO_PNA_BRO_duplex,0.99015,cRNA_duplex_context,200,61.50159,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0093,0.43841,14,0.38029,0.44064,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.30343,0,0.55936,literature_grounded_generated
+1.59914,ASO_PNA_BRO_duplex,0.99469,cRNA_duplex_context,200,59.23406,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0094,0.40796,14,0.46727,0.43692,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.24738,0,0.56308,literature_grounded_generated
+1.64892,ASO_PNA_BRO_duplex,0.9809,cRNA_duplex_context,200,62.15237,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0095,0.47095,14,0.42181,0.44295,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.27721,0,0.55705,literature_grounded_generated
+1.87977,ASO_PNA_BRO_duplex,0.97279,cRNA_duplex_context,200,60.87337,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0096,0.49102,14,0.4869,0.48808,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.25445,0,0.51192,literature_grounded_generated
+3.894,GalNAc_LNA_gapmer_ASO,0.91796,parent_mPCS1_ssASO,400,0.18439,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0097,0.70086,0,0.63405,0.81768,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.1777,0,0.18232,literature_grounded_generated
+3.9726,GalNAc_LNA_gapmer_ASO,0.90471,parent_mPCS1_ssASO,400,0.15525,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0098,0.81014,0,0.62056,0.84258,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.2014,0,0.15742,literature_grounded_generated
+4.05401,GalNAc_LNA_gapmer_ASO,0.92143,parent_mPCS1_ssASO,400,-0.44627,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0099,0.72831,0,0.63064,0.76066,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.17746,0,0.23934,literature_grounded_generated
+4.18683,GalNAc_LNA_gapmer_ASO,0.92824,parent_mPCS1_ssASO,400,0.52758,35.3,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0100,0.7113,0,0.5829,0.82313,toxic_active_parent,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.16789,0,0.17687,literature_grounded_generated
+0.84314,ASO_PNA_BRO_duplex,0.99859,BRO_PNA12_high_Tm,400,77.71019,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0101,0.22023,12,0.14971,0.18794,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.24658,1,0.81206,literature_grounded_generated
+0.6759,ASO_PNA_BRO_duplex,0.99945,BRO_PNA12_high_Tm,400,79.70498,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0102,0.15112,12,0.23668,0.22052,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.20819,1,0.77948,literature_grounded_generated
+0.7944,ASO_PNA_BRO_duplex,0.99603,BRO_PNA12_high_Tm,400,78.35253,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0103,0.16342,12,0.11586,0.21964,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.19353,1,0.78036,literature_grounded_generated
+0.72097,ASO_PNA_BRO_duplex,0.99128,BRO_PNA12_high_Tm,400,78.58956,78.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0104,0.21794,12,0.1983,0.29934,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.28268,1,0.70066,literature_grounded_generated
+0.76026,ASO_PNA_BRO_duplex,1.0024,BRO_PNA11_high_Tm,400,73.30023,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0105,0.37596,11,0.22778,0.3947,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.464,1,0.6053,literature_grounded_generated
+0.74714,ASO_PNA_BRO_duplex,0.98011,BRO_PNA11_high_Tm,400,72.84855,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0106,0.3897,11,0.21214,0.3819,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.48888,1,0.6181,literature_grounded_generated
+0.81479,ASO_PNA_BRO_duplex,1.00809,BRO_PNA11_high_Tm,400,76.03692,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0107,0.32946,11,0.27096,0.36925,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.38097,1,0.63075,literature_grounded_generated
+0.76431,ASO_PNA_BRO_duplex,1.0002,BRO_PNA11_high_Tm,400,74.74528,61.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0108,0.33421,11,0.19854,0.28773,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.41042,1,0.71227,literature_grounded_generated
+0.73869,ASO_PNA_BRO_duplex,0.97087,BRO_PNA10_balanced,400,63.95962,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0109,0.52635,10,0.26341,0.35227,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.66736,1,0.64773,literature_grounded_generated
+0.80814,ASO_PNA_BRO_duplex,0.99809,BRO_PNA10_balanced,400,62.54599,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0110,0.53816,10,0.27931,0.31704,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.62713,1,0.68296,literature_grounded_generated
+0.75488,ASO_PNA_BRO_duplex,0.99078,BRO_PNA10_balanced,400,62.89959,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0111,0.63777,10,0.29408,0.35484,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.79238,1,0.64516,literature_grounded_generated
+0.72983,ASO_PNA_BRO_duplex,0.98623,BRO_PNA10_balanced,400,62.43401,33.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0112,0.50815,10,0.28643,0.34464,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.65162,1,0.65536,literature_grounded_generated
+0.87429,ASO_PNA_BRO_duplex,0.99371,BRO_PNA_C8_optimized,400,57.77538,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0113,0.77984,8,0.26387,0.33106,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.84372,1,0.66894,literature_grounded_generated
+0.82863,ASO_PNA_BRO_duplex,0.9869,BRO_PNA_C8_optimized,400,58.86033,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0114,0.77919,8,0.375,0.3747,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.88682,1,0.6253,literature_grounded_generated
+0.7511,ASO_PNA_BRO_duplex,0.97952,BRO_PNA_C8_optimized,400,60.67718,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0115,0.77103,8,0.28949,0.31203,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.96246,1,0.68797,literature_grounded_generated
+0.76539,ASO_PNA_BRO_duplex,1.01396,BRO_PNA_C8_optimized,400,58.43324,21.7,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0116,0.67097,8,0.38678,0.36865,mitigated_hepatotoxicity,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.82287,1,0.63135,literature_grounded_generated
+1.63794,ASO_PNA_BRO_duplex,0.99487,cRNA_duplex_context,400,60.77736,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0117,0.40932,14,0.50581,0.4849,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.2425,0,0.5151,literature_grounded_generated
+1.7354,ASO_PNA_BRO_duplex,0.98547,cRNA_duplex_context,400,62.63864,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0118,0.49686,14,0.47258,0.53077,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.27829,0,0.46923,literature_grounded_generated
+1.73177,ASO_PNA_BRO_duplex,0.9741,cRNA_duplex_context,400,62.88525,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0119,0.40828,14,0.42268,0.4861,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.22914,0,0.5139,literature_grounded_generated
+1.63934,ASO_PNA_BRO_duplex,0.99613,cRNA_duplex_context,400,62.67445,55.0,Ability_to_Solve_Challenge|Feasibility_and_Rigor|Potential_Impact,direct_ASO_offtarget_hepatotoxicity_mitigation_features_and_labels,BRO_ASO_PNA_0120,0.41258,14,0.40779,0.44108,low_activity_or_context,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,0.24422,0,0.55892,literature_grounded_generated

evidence/cd81_galnac_sirna_malaria_protection.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.88,0.76,GalNAc-siRNA,Hep3B_and_primary_mouse_hepatocytes,hepatocyte_target_sequence_screening,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.82,inferred_from_paper,cross_species_siRNA_screen,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.16,literature_grounded_generated
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.92,0.78,GalNAc-siRNA,C57BL6_mouse_liver,durable_hepatocyte_receptor_silencing,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.86,inferred_from_paper,in_vivo_liver_CD81_knockdown_durability,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.18,literature_grounded_generated
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.9,0.8,GalNAc-siRNA,rodent_malaria_mouse_challenge,host_factor_infection_prevention_endpoint,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.88,inferred_from_paper,pyoelii_liver_stage_protection,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.18,literature_grounded_generated
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.88,0.82,GalNAc-siRNA,human_liver_chimeric_mouse,human_hepatocyte_translation_context,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.86,inferred_from_paper,pfalciparum_humanized_liver_context,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.2,literature_grounded_generated
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.86,0.84,host_target_silencing,hepatocyte_entry_receptor_model,host_factor_safety_and_efficacy_balance,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.72,inferred_from_paper,CD81_host_factor_risk_boundary,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.22,literature_grounded_generated
+ASM_105,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.84,0.72,GalNAc-siRNA,pharmacodynamic_duration_context,long_duration_siRNA_modeling_context,CD81_GalNAc_siRNA_liver_stage_malaria_protection,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.7,inferred_from_paper,long_duration_pd_context,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTION_2025,0.18,literature_grounded_generated

evidence/cholangiocyte_cholestasis_recovery_context.csv

@@ -0,0 +1,22 @@
+oligo_id,control_id,source_id,target_gene,modality,cell_model,cholestasis_context_flag,cholestasis_state,DDC_reversible_cholestasis_model_flag,ALT_fold_proxy,ALP_fold_proxy,bilirubin_fold_proxy,cholesterol_fold_proxy,ductular_reaction_CK19_SOX9_score_proxy,CX3CL1_expression_fold_proxy,CX3CR1_macrophage_recruitment_score_proxy,PICSS_pathway_activation_score_proxy,PICSS_upregulated_gene_count_proxy,NFYA_nuclear_activation_score_proxy,TGFB1_expression_score_proxy,fibrosis_collagen_activation_score_proxy,recovery_resolution_score_proxy,siRNA_NFYA_TGFB1_reduction_context_flag,siRNA_NFYA_TGFB1_reduction_fraction_proxy,direct_oligotox_hepatotoxicity_relevance,phase2_alignment,value_origin,assumption_id
+OLIGO_0000018,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,CYP2E1,GalNAc-siRNA,,1,generated_cholestatic_cholangiocyte_context,1,8.4074,2.4815,4.3333,1.9259,0.5988,3.5926,0.4593,0.5093,50,0.4407,0.4924,0.4708,0.6296,0,0.0,supporting_not_direct,endpoint_diversity_cholestasis_fibrosis_macrophage_context_translatability_documentation,literature_grounded_generated,ASM_041
+OLIGO_0000027,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,APOC3,gapmer,,1,generated_cholestatic_cholangiocyte_context,1,15.7998,3.96,7.6599,2.85,0.7427,6.1799,0.718,0.768,75,0.681,0.6245,0.5435,0.26,0,0.0,supporting_not_direct,endpoint_diversity_cholestasis_fibrosis_macrophage_context_translatability_documentation,literature_grounded_generated,ASM_041
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evidence/cpg_odn_apap_macrophage_immunomodulation.csv

@@ -0,0 +1,61 @@
+acod1_irg1_expression_score_proxy,alt_fold_baseline_proxy,apap_dose_mg_per_kg_context,cpg_odn_dose_mg_per_kg_context,hepatocyte_viability_proxy,inflammatory_cytokine_burden_proxy,interpretation,itaconate_metabolite_score_proxy,judging_alignment,macrophage_apoptosis_score_proxy,modeling_value,module_record_id,nfkb_activation_score_proxy,nrf2_antioxidant_response_score_proxy,oligodeoxynucleotide_class,ros_score_proxy,scenario,source_id,survival_improvement_score_proxy,target_cell_context,tlr9_activation_score_proxy,value_origin
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+0.10382,5.99651,300,0.0,0.36465,0.70065,APAP_liver_injury_reference,0.2721,Potential_Impact|Feasibility_and_Rigor,0.58769,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0021,0.0,0.38923,CpG_ODN_1826_like,0.68743,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.31595,AML12_hepatocyte_coculture,0.0,literature_grounded_generated
+0.79224,2.99956,300,1.65,0.77796,0.438,protective_macrophage_immunomodulation,0.75132,Potential_Impact|Feasibility_and_Rigor,0.04449,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0022,0.67815,0.81809,CpG_ODN_1826_like,0.38476,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.76923,AML12_hepatocyte_coculture,0.75047,literature_grounded_generated
+0.89602,3.04724,300,1.65,0.73742,0.32815,protective_macrophage_immunomodulation,0.84812,Potential_Impact|Feasibility_and_Rigor,0.25295,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0023,0.65641,0.6983,CpG_ODN_1826_like,0.21504,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.82025,Kupffer_cell,0.78612,literature_grounded_generated
+0.21336,5.88089,300,1.65,0.54734,0.52776,loss_of_mechanism_control,0.24154,Potential_Impact|Feasibility_and_Rigor,0.39324,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0024,0.72763,0.54267,CpG_ODN_1826_like,0.79431,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.37356,liver_macrophage_reinfusion,0.80295,literature_grounded_generated
+0.7772,3.02212,300,0.0,0.77585,0.30656,protective_macrophage_immunomodulation,0.80875,Potential_Impact|Feasibility_and_Rigor,0.11596,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0025,0.0,0.67641,CpG_ODN_1826_like,0.29259,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.62657,AML12_hepatocyte_coculture,0.0,literature_grounded_generated
+0.0,5.14017,300,0.0,0.26437,0.72669,APAP_liver_injury_reference,0.07704,Potential_Impact|Feasibility_and_Rigor,0.68981,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0026,0.0,0.32195,CpG_ODN_1826_like,0.95368,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.21356,AML12_hepatocyte_coculture,0.0,literature_grounded_generated
+0.75365,2.7009,300,1.65,0.70271,0.29477,protective_macrophage_immunomodulation,0.71253,Potential_Impact|Feasibility_and_Rigor,0.29259,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0027,0.83842,0.67656,CpG_ODN_1826_like,0.27457,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.81132,Kupffer_cell,0.79466,literature_grounded_generated
+0.93359,2.54503,300,1.65,0.86522,0.25757,protective_macrophage_immunomodulation,0.93876,Potential_Impact|Feasibility_and_Rigor,0.12191,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0028,0.6667,0.78759,CpG_ODN_1826_like,0.199,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.73005,RAW2647_macrophage,0.68719,literature_grounded_generated
+0.13896,5.7686,300,1.65,0.54024,0.5062,loss_of_mechanism_control,0.17805,Potential_Impact|Feasibility_and_Rigor,0.56881,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0029,0.79749,0.21403,CpG_ODN_1826_like,0.49071,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.34368,RAW2647_macrophage,0.6613,literature_grounded_generated
+0.7857,3.16721,300,0.0,0.76843,0.21817,protective_macrophage_immunomodulation,0.8086,Potential_Impact|Feasibility_and_Rigor,0.16195,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0030,0.0,0.68611,CpG_ODN_1826_like,0.25849,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.55465,liver_macrophage_reinfusion,0.0,literature_grounded_generated
+0.00549,4.96917,300,0.0,0.37078,0.85687,APAP_liver_injury_reference,0.12195,Potential_Impact|Feasibility_and_Rigor,0.70746,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0031,0.0,0.35897,CpG_ODN_1826_like,0.72137,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.27418,Kupffer_cell,0.0,literature_grounded_generated
+0.70698,2.16713,300,1.65,0.89249,0.29803,protective_macrophage_immunomodulation,0.65343,Potential_Impact|Feasibility_and_Rigor,0.32753,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0032,0.78447,0.59425,CpG_ODN_1826_like,0.34025,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.80523,liver_macrophage_reinfusion,0.86271,literature_grounded_generated
+0.81552,2.88572,300,1.65,0.93736,0.43584,protective_macrophage_immunomodulation,0.81747,Potential_Impact|Feasibility_and_Rigor,0.11285,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0033,0.64634,0.74267,CpG_ODN_1826_like,0.13217,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.70251,Kupffer_cell,0.74534,literature_grounded_generated
+0.19026,5.52597,300,1.65,0.60483,0.70195,loss_of_mechanism_control,0.23419,Potential_Impact|Feasibility_and_Rigor,0.64284,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0034,0.85248,0.46043,CpG_ODN_1826_like,0.6206,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.32187,Kupffer_cell,0.75364,literature_grounded_generated
+0.64438,2.66762,300,0.0,0.7335,0.21362,protective_macrophage_immunomodulation,0.70568,Potential_Impact|Feasibility_and_Rigor,0.21614,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0035,0.0,0.76251,CpG_ODN_1826_like,0.30715,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.75046,Kupffer_cell,0.0,literature_grounded_generated
+0.10273,4.69852,300,0.0,0.38095,0.68242,APAP_liver_injury_reference,0.13382,Potential_Impact|Feasibility_and_Rigor,0.78226,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0036,0.0,0.17538,CpG_ODN_1826_like,0.74173,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.30123,liver_macrophage_reinfusion,0.0,literature_grounded_generated
+0.73005,3.33234,300,1.65,0.86593,0.40754,protective_macrophage_immunomodulation,0.77499,Potential_Impact|Feasibility_and_Rigor,0.22009,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0037,0.62752,0.65758,CpG_ODN_1826_like,0.30548,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.78712,Kupffer_cell,0.77042,literature_grounded_generated
+0.8862,2.67854,300,1.65,0.83054,0.15474,protective_macrophage_immunomodulation,0.8125,Potential_Impact|Feasibility_and_Rigor,0.23318,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0038,0.81018,0.61534,CpG_ODN_1826_like,0.21659,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.81655,RAW2647_macrophage,0.68291,literature_grounded_generated
+0.15382,5.59618,300,1.65,0.56354,0.5553,loss_of_mechanism_control,0.18904,Potential_Impact|Feasibility_and_Rigor,0.63653,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0039,0.68346,0.36266,CpG_ODN_1826_like,0.76435,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.2736,liver_macrophage_reinfusion,0.76344,literature_grounded_generated
+0.78406,3.95172,300,0.0,0.73178,0.33597,protective_macrophage_immunomodulation,0.88362,Potential_Impact|Feasibility_and_Rigor,0.0521,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0040,0.0,0.79831,CpG_ODN_1826_like,0.25624,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.71226,liver_macrophage_reinfusion,0.0,literature_grounded_generated
+0.02377,4.78524,300,0.0,0.30055,0.80383,APAP_liver_injury_reference,0.02837,Potential_Impact|Feasibility_and_Rigor,0.60574,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0041,0.0,0.24425,CpG_ODN_1826_like,0.80987,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.25676,Kupffer_cell,0.0,literature_grounded_generated
+0.69715,3.05172,300,1.65,0.90746,0.36442,protective_macrophage_immunomodulation,0.64784,Potential_Impact|Feasibility_and_Rigor,0.25578,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0042,0.80961,0.70849,CpG_ODN_1826_like,0.29454,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.67043,Kupffer_cell,0.78078,literature_grounded_generated
+1.0,3.1614,300,1.65,0.80265,0.20536,protective_macrophage_immunomodulation,0.92985,Potential_Impact|Feasibility_and_Rigor,0.07254,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0043,0.64375,0.90188,CpG_ODN_1826_like,0.28732,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.70458,RAW2647_macrophage,0.64468,literature_grounded_generated
+0.32245,5.11339,300,1.65,0.54413,0.46773,loss_of_mechanism_control,0.45556,Potential_Impact|Feasibility_and_Rigor,0.46274,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0044,0.7168,0.48052,CpG_ODN_1826_like,0.53249,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.24415,RAW2647_macrophage,0.84871,literature_grounded_generated
+0.82694,3.29199,300,0.0,0.76138,0.34793,protective_macrophage_immunomodulation,0.79317,Potential_Impact|Feasibility_and_Rigor,0.21891,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0045,0.0,0.75413,CpG_ODN_1826_like,0.28597,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.65926,liver_macrophage_reinfusion,0.0,literature_grounded_generated
+0.07184,5.08779,300,0.0,0.24448,0.74206,APAP_liver_injury_reference,0.13919,Potential_Impact|Feasibility_and_Rigor,0.56928,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0046,0.0,0.32222,CpG_ODN_1826_like,0.76893,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.26558,Kupffer_cell,0.0,literature_grounded_generated
+0.86722,2.83911,300,1.65,0.86339,0.27113,protective_macrophage_immunomodulation,0.80667,Potential_Impact|Feasibility_and_Rigor,0.11366,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0047,0.63527,0.92099,CpG_ODN_1826_like,0.28818,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.61043,liver_macrophage_reinfusion,0.70376,literature_grounded_generated
+0.7934,2.0607,300,1.65,0.97363,0.32084,protective_macrophage_immunomodulation,0.79043,Potential_Impact|Feasibility_and_Rigor,0.1564,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0048,0.79425,0.85984,CpG_ODN_1826_like,0.37567,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.78526,Kupffer_cell,0.74607,literature_grounded_generated
+0.24374,5.54051,300,1.65,0.61093,0.74519,loss_of_mechanism_control,0.27896,Potential_Impact|Feasibility_and_Rigor,0.58905,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0049,0.57772,0.53265,CpG_ODN_1826_like,0.63691,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.29686,RAW2647_macrophage,0.77607,literature_grounded_generated
+0.90068,3.16248,300,0.0,0.77491,0.32937,protective_macrophage_immunomodulation,0.8041,Potential_Impact|Feasibility_and_Rigor,0.18877,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0050,0.0,0.75149,CpG_ODN_1826_like,0.18264,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.71247,Kupffer_cell,0.0,literature_grounded_generated
+0.0,5.32875,300,0.0,0.19878,0.89278,APAP_liver_injury_reference,0.11067,Potential_Impact|Feasibility_and_Rigor,0.54027,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0051,0.0,0.27274,CpG_ODN_1826_like,0.77836,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.43003,Kupffer_cell,0.0,literature_grounded_generated
+0.82058,2.49034,300,1.65,0.80825,0.30417,protective_macrophage_immunomodulation,0.76837,Potential_Impact|Feasibility_and_Rigor,0.22279,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0052,0.76875,0.72476,CpG_ODN_1826_like,0.28512,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.75755,RAW2647_macrophage,0.81054,literature_grounded_generated
+0.84365,2.63341,300,1.65,0.77716,0.35589,protective_macrophage_immunomodulation,0.75593,Potential_Impact|Feasibility_and_Rigor,0.25301,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0053,0.79127,0.6591,CpG_ODN_1826_like,0.3212,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.5807,AML12_hepatocyte_coculture,0.70622,literature_grounded_generated
+0.22166,5.30627,300,1.65,0.4608,0.76216,loss_of_mechanism_control,0.27574,Potential_Impact|Feasibility_and_Rigor,0.48233,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0054,0.75899,0.49866,CpG_ODN_1826_like,0.62203,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.38749,RAW2647_macrophage,0.81784,literature_grounded_generated
+0.79513,2.76207,300,0.0,0.67894,0.31447,protective_macrophage_immunomodulation,0.73409,Potential_Impact|Feasibility_and_Rigor,0.12501,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0055,0.0,0.74281,CpG_ODN_1826_like,0.33928,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.63622,RAW2647_macrophage,0.0,literature_grounded_generated
+0.0,4.74584,300,0.0,0.23559,0.87889,APAP_liver_injury_reference,0.02899,Potential_Impact|Feasibility_and_Rigor,0.77473,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0056,0.0,0.14523,CpG_ODN_1826_like,0.97315,APAP_only,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.2376,Kupffer_cell,0.0,literature_grounded_generated
+0.76292,2.43337,300,1.65,0.79193,0.38467,protective_macrophage_immunomodulation,0.72566,Potential_Impact|Feasibility_and_Rigor,0.30653,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0057,0.66472,0.63042,CpG_ODN_1826_like,0.3355,CpG_ODN_pretreatment,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.75675,AML12_hepatocyte_coculture,0.66938,literature_grounded_generated
+0.89297,2.84632,300,1.65,0.90942,0.2586,protective_macrophage_immunomodulation,0.85694,Potential_Impact|Feasibility_and_Rigor,0.08724,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0058,0.79252,0.73736,CpG_ODN_1826_like,0.2374,CpG_ODN_treated_macrophage_reinfusion,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.70204,AML12_hepatocyte_coculture,0.91523,literature_grounded_generated
+0.12948,5.58242,300,1.65,0.4441,0.59758,loss_of_mechanism_control,0.19051,Potential_Impact|Feasibility_and_Rigor,0.52421,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0059,0.57205,0.47428,CpG_ODN_1826_like,0.79859,CpG_ODN_plus_Acod1_siRNA_interference,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.27168,Kupffer_cell,0.63848,literature_grounded_generated
+0.73699,3.48753,300,0.0,0.80838,0.41121,protective_macrophage_immunomodulation,0.75995,Potential_Impact|Feasibility_and_Rigor,0.24594,immune_cell_liver_injury_context_and_mechanistic_covariates,CPG_APAP_0060,0.0,0.86984,CpG_ODN_1826_like,0.28399,itaconate_or_4OI_context,QU_CPG_ODN_APAP_TLR9_IRG1_2025,0.73688,liver_macrophage_reinfusion,0.0,literature_grounded_generated

evidence/cuproptosis_wilson_liver_injury.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.12,0.84,liver_injury_context,ATP7B_knockout_mouse_Wilson_disease_model,copper_overload_ALT_AST_LDH_hepatocellular_injury_context,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.76,inferred_from_paper,ATP7B_KO_copper_overload_liver_injury,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.64,literature_grounded_generated
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.16,0.88,regulated_cell_death_mechanism,ATP7B_KO_liver_and_HepG2_cuproptosis_model,FDX1_DLAT_DLST_LIAS_mitochondrial_cell_death_context,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.72,inferred_from_paper,cuproptosis_marker_activation,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.56,literature_grounded_generated
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.18,0.82,dose_response_stress,copper_exposed_HepG2_model,copper_dose_viability_and_cytotoxicity_readout_context,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.74,inferred_from_paper,copper_exposure_LDH_viability_shift,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.6,literature_grounded_generated
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.2,0.86,mechanistic_modulation,cuproptosis_activation_inhibition_cell_model,positive_negative_modulator_context_for_cell_death_axis,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.7,inferred_from_paper,elesclomol_TTM_cuproptosis_modulation,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.5,literature_grounded_generated
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.36,0.9,siRNA_knockdown,ATP7B_KO_HepG2_siRNA_validation_model,siRNA_target_validation_and_toxicity_rescue_context,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.78,inferred_from_paper,GPC1_GLS_LOX_APP_siRNA_rescue,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.34,literature_grounded_generated
+ASM_122,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.14,0.84,biomarker_context,patient_serum_and_mouse_validation_context,serum_biomarker_and_therapeutic_target_context,ATP7B_copper_cuproptosis_liver_injury_siRNA_rescue_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.68,inferred_from_paper,WD_biomarker_candidate_targets,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,0.48,literature_grounded_generated

evidence/dilimap_toxpredictor_dili_toxicogenomics.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.32,0.94,toxicogenomics,sandwich_cultured_primary_human_hepatocytes,large_scale_human_hepatocyte_reference_resource,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.72,inferred_from_paper,PHH_RNAseq_300_compound_library,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.2,literature_grounded_generated
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.36,0.92,ML_toxicity_model,multi_concentration_transcriptomics_PK_context,dose_and_exposure_resolved_modeling_context,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.74,inferred_from_paper,dose_resolved_DILI_safety_margin,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.22,literature_grounded_generated
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.36,0.96,random_forest_model,DILI_positive_negative_validation,validation_sensitivity_specificity_context,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.78,inferred_from_paper,blind_validation_high_specificity,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.18,literature_grounded_generated
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.38,0.94,RNAseq_pathway_signatures,mechanistic_DILI_response,systems_level_hepatotoxicity_mechanisms,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.82,inferred_from_paper,mitochondrial_oxidative_immune_metabolic_signatures,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.3,literature_grounded_generated
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.34,0.9,transcriptomic_modeling,early_transcriptional_response,risk_detection_before_cell_death_context,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.76,inferred_from_paper,noncytotoxic_risk_detection,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.26,literature_grounded_generated
+ASM_111,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.32,0.92,model_comparison,DILIrank_LiverTox_reference_context,reviewer_facing_model_rigor_context,DILImap_ToxPredictor_DILI_toxicogenomics,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.7,inferred_from_paper,benchmarking_against_preclinical_models,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,0.2,literature_grounded_generated

evidence/dual_rgd_sirna_nanocarrier_delivery.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,immune_or_cell_state_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.7,0.45,noncationic_protein_carrier,in_vitro_binding,load_to_go_siRNA_binding,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.88,inferred_from_paper,dual_RGD_dsRBD_18His_binding,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.16,literature_grounded_generated
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.62,0.4,noncationic_protein_carrier,serum_RNase_assay,siRNA_protection_context,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.82,inferred_from_paper,RNase_serum_stability,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.14,literature_grounded_generated
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.82,0.55,dual_RGD_targeting,integrin_positive_cells,tumor_targeting_context,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.76,inferred_from_paper,integrin_avb3_targeting,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.18,literature_grounded_generated
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.72,0.5,histidine_buffering,cellular_delivery,endosomal_escape_context,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.7,inferred_from_paper,18His_endosomal_escape,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.2,literature_grounded_generated
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.76,0.55,dual_RGD_siRNA_complex,tumor_xenograft,extrahepatic_in_vivo_delivery_context,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.72,inferred_from_paper,tumor_xenograft_gene_knockdown,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.22,literature_grounded_generated
+ASM_101,"supporting module for delivery, immune-cell pharmacology, or biodistribution context; not treated as direct hepatotoxicity evidence unless explicitly labeled",0.6,0.45,protein_nanocarrier,safety_context,low_toxicity_comparator_context,dual_RGD_non_cationic_siRNA_delivery,Generated qualitative scenario row; proxy values encode relative literature-grounded patterns without reproducing source tables or figures.,0.64,inferred_from_paper,low_toxicity_biodegradable_carrier,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELIVERY_2021,0.12,literature_grounded_generated

evidence/erbb2_aptamer_pet_pk.csv

@@ -0,0 +1,56 @@
+aptamer_length_nt_context,auc_0_5400_proxy,biliary_excretion_fraction_context,cmax_percent_injected_dose_per_g_proxy,dominant_excretion_or_distribution_route,estimated_effective_dose_mGy_per_MBq_context,hepatobiliary_or_renal_burden_flag,judging_alignment,modeling_value,module_record_id,oligonucleotide_type,organ_or_tissue,radiolabeling_strategy,renal_excretion_fraction_context,route,source_id,target,target_visualization_score_proxy,terminal_half_life_seconds_proxy,tmax_seconds_proxy,value_origin
+40,12.30571,,7.32945,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0001,ERBB2_specific_DNA_aptamer,heart,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.43803,1605.21774,222.74629,literature_grounded_generated
+40,12.67163,,7.74009,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0002,ERBB2_specific_DNA_aptamer,heart,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.46311,1787.76691,332.91156,literature_grounded_generated
+40,15.87586,,7.89772,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0003,ERBB2_specific_DNA_aptamer,heart,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.48553,1645.95571,278.52277,literature_grounded_generated
+40,15.04532,,7.97236,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0004,ERBB2_specific_DNA_aptamer,heart,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.50359,1498.23566,215.92794,literature_grounded_generated
+40,16.22244,,7.11035,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0005,ERBB2_specific_DNA_aptamer,heart,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.46286,1566.34644,238.10991,literature_grounded_generated
+40,14.17497,,5.65096,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0006,ERBB2_specific_DNA_aptamer,kidney,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.34668,2164.98496,386.73354,literature_grounded_generated
+40,10.91084,,6.42572,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0007,ERBB2_specific_DNA_aptamer,kidney,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.43426,1811.35939,325.24057,literature_grounded_generated
+40,12.61153,,6.03534,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0008,ERBB2_specific_DNA_aptamer,kidney,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.37654,1832.04424,315.22917,literature_grounded_generated
+40,20.38094,,6.37709,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0009,ERBB2_specific_DNA_aptamer,kidney,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.40346,2792.76363,269.81426,literature_grounded_generated
+40,14.08184,,5.77117,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0010,ERBB2_specific_DNA_aptamer,kidney,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.36905,2307.29204,373.00018,literature_grounded_generated
+40,11.01287,,3.81213,hepatic_biliary_context,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0011,ERBB2_specific_DNA_aptamer,liver,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.28023,2587.49572,331.62692,literature_grounded_generated
+40,12.00506,,4.07376,hepatic_biliary_context,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0012,ERBB2_specific_DNA_aptamer,liver,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.35532,2370.57489,490.81066,literature_grounded_generated
+40,9.51181,,3.89666,hepatic_biliary_context,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0013,ERBB2_specific_DNA_aptamer,liver,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.35973,1773.15271,430.22682,literature_grounded_generated
+40,14.91676,,3.68722,hepatic_biliary_context,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0014,ERBB2_specific_DNA_aptamer,liver,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.26212,2896.90175,380.71765,literature_grounded_generated
+40,16.97648,,3.99521,hepatic_biliary_context,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0015,ERBB2_specific_DNA_aptamer,liver,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.30372,2988.71425,422.72761,literature_grounded_generated
+40,6.6917,,3.84483,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0016,ERBB2_specific_DNA_aptamer,lung,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.29913,1349.94571,280.98298,literature_grounded_generated
+40,6.0687,,3.70532,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0017,ERBB2_specific_DNA_aptamer,lung,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.27897,1197.66433,219.75984,literature_grounded_generated
+40,6.46682,,3.61148,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0018,ERBB2_specific_DNA_aptamer,lung,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.27229,1562.15771,291.99361,literature_grounded_generated
+40,5.59331,,3.85091,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0019,ERBB2_specific_DNA_aptamer,lung,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.26646,1443.54787,283.32608,literature_grounded_generated
+40,7.54621,,4.07526,systemic_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0020,ERBB2_specific_DNA_aptamer,lung,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.33681,1618.33826,109.37875,literature_grounded_generated
+40,7.73113,0.083,3.11415,biliary_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0021,ERBB2_specific_DNA_aptamer,gall_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.27686,2876.08733,1382.1521,literature_grounded_generated
+40,11.79008,0.083,3.47011,biliary_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0022,ERBB2_specific_DNA_aptamer,gall_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.30415,2696.44633,1552.87978,literature_grounded_generated
+40,12.66101,0.083,3.12085,biliary_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0023,ERBB2_specific_DNA_aptamer,gall_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.26936,3471.47218,1245.4116,literature_grounded_generated
+40,11.03254,0.083,3.02589,biliary_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0024,ERBB2_specific_DNA_aptamer,gall_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.20517,3366.90918,1489.38497,literature_grounded_generated
+40,12.2573,0.083,3.16881,biliary_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0025,ERBB2_specific_DNA_aptamer,gall_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.19531,3440.95231,1314.09005,literature_grounded_generated
+40,5.53164,,2.75348,reticuloendothelial_exposure,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0026,ERBB2_specific_DNA_aptamer,spleen,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.26214,1797.17646,682.89402,literature_grounded_generated
+40,9.3799,,2.73633,reticuloendothelial_exposure,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0027,ERBB2_specific_DNA_aptamer,spleen,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.24365,2734.82207,693.03846,literature_grounded_generated
+40,9.02429,,3.18055,reticuloendothelial_exposure,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0028,ERBB2_specific_DNA_aptamer,spleen,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.24794,2086.34976,706.79564,literature_grounded_generated
+40,8.52926,,2.50659,reticuloendothelial_exposure,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0029,ERBB2_specific_DNA_aptamer,spleen,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.27594,2863.06512,489.8621,literature_grounded_generated
+40,7.9456,,2.865,reticuloendothelial_exposure,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0030,ERBB2_specific_DNA_aptamer,spleen,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.27659,2274.80927,672.07601,literature_grounded_generated
+40,4.37106,,2.65197,background_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0031,ERBB2_specific_DNA_aptamer,stomach,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.24185,1633.70362,1013.09877,literature_grounded_generated
+40,7.4263,,2.34365,background_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0032,ERBB2_specific_DNA_aptamer,stomach,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.21834,2107.3564,722.11274,literature_grounded_generated
+40,7.28086,,2.43578,background_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0033,ERBB2_specific_DNA_aptamer,stomach,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.19753,2260.47559,839.41907,literature_grounded_generated
+40,7.21626,,2.50579,background_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0034,ERBB2_specific_DNA_aptamer,stomach,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.24721,2187.67133,872.17924,literature_grounded_generated
+40,4.88744,,2.28013,background_distribution,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0035,ERBB2_specific_DNA_aptamer,stomach,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.25106,1749.7207,792.71276,literature_grounded_generated
+40,1.08722,,0.58952,low_initial_uptake,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0036,ERBB2_specific_DNA_aptamer,brain,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.14443,1268.04142,919.18551,literature_grounded_generated
+40,0.58371,,0.4648,low_initial_uptake,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0037,ERBB2_specific_DNA_aptamer,brain,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.10283,952.76779,729.25692,literature_grounded_generated
+40,0.58211,,0.44853,low_initial_uptake,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0038,ERBB2_specific_DNA_aptamer,brain,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.08932,1117.38423,844.21862,literature_grounded_generated
+40,0.51334,,0.34538,low_initial_uptake,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0039,ERBB2_specific_DNA_aptamer,brain,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.04575,1133.57962,802.694,literature_grounded_generated
+40,0.3334,,0.27613,low_initial_uptake,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0040,ERBB2_specific_DNA_aptamer,brain,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.15454,1215.02557,853.52078,literature_grounded_generated
+40,0.33305,,0.16105,low_background,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0041,ERBB2_specific_DNA_aptamer,muscle,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.10218,1314.42193,701.13072,literature_grounded_generated
+40,0.23878,,0.134,low_background,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0042,ERBB2_specific_DNA_aptamer,muscle,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.12894,1451.08548,659.51213,literature_grounded_generated
+40,0.47609,,0.30941,low_background,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0043,ERBB2_specific_DNA_aptamer,muscle,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.0907,1377.4248,765.0722,literature_grounded_generated
+40,0.90804,,0.42201,low_background,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0044,ERBB2_specific_DNA_aptamer,muscle,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.15537,1571.3109,763.48253,literature_grounded_generated
+40,0.48801,,0.25823,low_background,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0045,ERBB2_specific_DNA_aptamer,muscle,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.14397,1418.45961,742.96655,literature_grounded_generated
+40,41.30303,,9.5462,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0046,ERBB2_specific_DNA_aptamer,urinary_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.5826,3237.83778,2071.81739,literature_grounded_generated
+40,51.92833,,9.1407,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0047,ERBB2_specific_DNA_aptamer,urinary_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.48265,3827.55954,2246.83749,literature_grounded_generated
+40,40.05877,,9.47701,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0048,ERBB2_specific_DNA_aptamer,urinary_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.56948,3089.87368,2395.14661,literature_grounded_generated
+40,44.9472,,9.33773,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0049,ERBB2_specific_DNA_aptamer,urinary_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.55071,3323.42019,2570.95511,literature_grounded_generated
+40,27.99501,,9.74658,renal_excretion,0.00189,1,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0050,ERBB2_specific_DNA_aptamer,urinary_bladder,fluorine18_complementary_oligonucleotide_hybridization_platform,0.778,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.57725,2438.75908,2691.78975,literature_grounded_generated
+40,19.93801,,4.62549,target_visualization,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0051,ERBB2_specific_DNA_aptamer,ERBB2_positive_tumor,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.85,3983.89599,1306.19571,literature_grounded_generated
+40,16.78843,,4.75752,target_visualization,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0052,ERBB2_specific_DNA_aptamer,ERBB2_positive_tumor,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.85,2615.45489,1499.8529,literature_grounded_generated
+40,13.00562,,4.41491,target_visualization,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0053,ERBB2_specific_DNA_aptamer,ERBB2_positive_tumor,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.85,2333.75057,1577.29096,literature_grounded_generated
+40,17.45885,,4.90186,target_visualization,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0054,ERBB2_specific_DNA_aptamer,ERBB2_positive_tumor,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.85,2821.43941,1225.82727,literature_grounded_generated
+40,19.79434,,4.37573,target_visualization,0.00189,0,Feasibility_and_Rigor|Transparency_and_Reproducibility|Potential_Impact,oligonucleotide_ADME_PK_context,ERBB2_APT_PK_0055,ERBB2_specific_DNA_aptamer,ERBB2_positive_tumor,fluorine18_complementary_oligonucleotide_hybridization_platform,,intravenous,PARK_ERBB2_APTAMER_PET_PK_2023,ERBB2,0.85,3563.9262,1258.19327,literature_grounded_generated

evidence/escplus_seed_pairing_safety_mechanism.csv

@@ -0,0 +1,26 @@
+ALT_elevation_liability_proxy,ESCplus_flag,GNA_seed_flag,assumption_id,challenge_gap_addressed,chemistry_vs_global_tm_note,design_class,dose_mg_per_kg_proxy,judging_alignment,modality,modeling_value,module_record_id,on_target_activity_retention_proxy,predicted_offtarget_transcript_dysregulation_proxy,seed_mediated_offtarget_binding_proxy,seed_pairing_destabilization_score_proxy,seed_region_modification,source_id,source_role,target_context,therapeutic_window_proxy,value_origin
+0.14811,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,parent_ESC_GalNAc_siRNA,1,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_parent_ESC_GalNAc_siRNA_1mgkg,1.0,0.02201,0.14563,0.85153,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.04772,literature_grounded_generated
+0.20586,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,parent_ESC_GalNAc_siRNA,3,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_parent_ESC_GalNAc_siRNA_3mgkg,0.97451,0.20319,0.23173,0.84323,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.52553,literature_grounded_generated
+0.45626,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,parent_ESC_GalNAc_siRNA,10,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_parent_ESC_GalNAc_siRNA_10mgkg,0.9318,0.35283,0.41861,0.82614,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.46449,literature_grounded_generated
+0.59682,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,parent_ESC_GalNAc_siRNA,30,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_parent_ESC_GalNAc_siRNA_30mgkg,1.0,0.52774,0.56347,0.84051,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.2873,literature_grounded_generated
+0.80278,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,parent_ESC_GalNAc_siRNA,100,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_parent_ESC_GalNAc_siRNA_100mgkg,1.0,0.72332,0.78153,0.83625,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.01752,literature_grounded_generated
+0.05609,1,1,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_GNA_position6,1,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_GNA_position6_1mgkg,0.93817,0.02172,0.0,0.93722,GNA_position6,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.97381,literature_grounded_generated
+0.14524,1,1,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_GNA_position6,3,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_GNA_position6_3mgkg,0.92427,0.06596,0.04397,0.9065,GNA_position6,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.8418,literature_grounded_generated
+0.20024,1,1,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_GNA_position6,10,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_GNA_position6_10mgkg,0.93068,0.10551,0.13257,0.92646,GNA_position6,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.44762,literature_grounded_generated
+0.20969,1,1,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_GNA_position6,30,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_GNA_position6_30mgkg,0.87865,0.14853,0.23407,0.91285,GNA_position6,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.25474,literature_grounded_generated
+0.26377,1,1,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_GNA_position6,100,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_GNA_position6_100mgkg,0.94773,0.25131,0.30889,0.93793,GNA_position6,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.13562,literature_grounded_generated
+0.09555,1,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_2_5_RNA_seed,1,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_2_5_RNA_seed_1mgkg,0.87775,0.04012,0.01476,0.91864,2_5_RNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.18542,literature_grounded_generated
+0.0458,1,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_2_5_RNA_seed,3,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_2_5_RNA_seed_3mgkg,0.88883,0.06231,0.10997,0.90376,2_5_RNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.93631,literature_grounded_generated
+0.20245,1,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_2_5_RNA_seed,10,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_2_5_RNA_seed_10mgkg,0.88959,0.19907,0.14788,0.89528,2_5_RNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.32602,literature_grounded_generated
+0.31642,1,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_2_5_RNA_seed,30,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_2_5_RNA_seed_30mgkg,0.93266,0.19449,0.24451,0.90057,2_5_RNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.87878,literature_grounded_generated
+0.30898,1,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,ESCplus_single_2_5_RNA_seed,100,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_ESCplus_single_2_5_RNA_seed_100mgkg,0.9289,0.28625,0.30397,0.89319,2_5_RNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.89967,literature_grounded_generated
+0.14389,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,multi_DNA_seed_destabilized,1,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_multi_DNA_seed_destabilized_1mgkg,0.77491,0.07918,0.10957,0.84042,multi_DNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.39249,literature_grounded_generated
+0.2527,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,multi_DNA_seed_destabilized,3,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_multi_DNA_seed_destabilized_3mgkg,0.73932,0.15432,0.15776,0.89374,multi_DNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.70861,literature_grounded_generated
+0.34442,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,multi_DNA_seed_destabilized,10,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_multi_DNA_seed_destabilized_10mgkg,0.75835,0.32785,0.36114,0.86577,multi_DNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.44607,literature_grounded_generated
+0.527,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,multi_DNA_seed_destabilized,30,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_multi_DNA_seed_destabilized_30mgkg,0.71626,0.40092,0.45688,0.84738,multi_DNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.01309,literature_grounded_generated
+0.65077,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,multi_DNA_seed_destabilized,100,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_multi_DNA_seed_destabilized_100mgkg,0.66985,0.5729,0.58096,0.85513,multi_DNA_seed,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,0.8063,literature_grounded_generated
+0.04933,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,non_hepatotoxic_ESC_comparator,1,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_non_hepatotoxic_ESC_comparator_1mgkg,0.88212,0.00082,0.02344,0.9013,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.8465,literature_grounded_generated
+0.09026,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,non_hepatotoxic_ESC_comparator,3,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_non_hepatotoxic_ESC_comparator_3mgkg,0.86738,0.05073,0.08448,0.90102,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.20935,literature_grounded_generated
+0.05323,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,non_hepatotoxic_ESC_comparator,10,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_non_hepatotoxic_ESC_comparator_10mgkg,0.89365,0.09754,0.14777,0.89402,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,3.83158,literature_grounded_generated
+0.253,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,non_hepatotoxic_ESC_comparator,30,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_non_hepatotoxic_ESC_comparator_30mgkg,0.89162,0.18214,0.2289,0.90053,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,2.05915,literature_grounded_generated
+0.26926,0,0,ASM_062,public_data_gap_for_GalNAc_siRNA_seed_offtarget_hepatotoxicity_and_ESCplus_safety_mitigation,single_seed_GNA_or_2_5_RNA_modeled_as_specific_offtarget_mitigation_not_merely_global_Tm_change,non_hepatotoxic_ESC_comparator,100,Ability_to_Solve|Potential_Impact|Feasibility_and_Rigor|Transparency_and_Reproducibility,GalNAc_siRNA,"directly supports seed-region chemistry, off-target, ALT, and therapeutic-window features for siRNA hepatotoxicity models",supplemental_ESCPLUS_non_hepatotoxic_ESC_comparator_100mgkg,0.89569,0.23862,0.26116,0.90538,none,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022,direct_GalNAc_siRNA_offtarget_hepatotoxicity_mitigation,HBV_or_liver_expressed_target_context,1.9937,literature_grounded_generated

evidence/ezh2_exon_skipping_hcc_aso.csv

@@ -0,0 +1,7 @@
+EMT_reversal_score_proxy,H3K27me3_residual_score_proxy,apoptosis_or_cell_cycle_effect_score_proxy,challenge_alignment,exon14_skipping_score_proxy,full_length_EZH2_residual_score_proxy,liver_relevance,mechanism,model_system,modeling_role,module_id,notes,oligo_modality,provenance_label,scenario_id,source_id,study_context,target_or_splicing_element,tumor_growth_inhibition_score_proxy,value_origin
+0.06,0.9,0.08,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.03,0.92,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,MHCC97H_HCC,baseline_HCC_control,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,buffer_control_HCC_cells,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vitro,none,0.1,literature_grounded_generated
+0.08,0.82,0.12,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.06,0.86,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,MHCC97H_HCC,sequence_specificity_control,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,mismatch_MOE_PS_ASO,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vitro,mismatch_control,0.14,literature_grounded_generated
+0.35,0.18,0.78,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.88,0.2,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,MHCC97H_HCC,lead_splice_switching_ASO,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,lead_ASO35_58_25nM,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vitro,EZH2_exon14_ESE,0.74,literature_grounded_generated
+0.4,0.12,0.84,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.94,0.14,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,HCCLM3_HCC,dose_response_splice_switching_ASO,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,lead_ASO35_58_50nM,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vitro,EZH2_exon14_ESE,0.8,literature_grounded_generated
+0.25,0.25,0.6,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.76,0.3,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,mouse_peripheral_tissue_liver_context,systemic_distribution_PD_context,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,systemic_ASO_peripheral_tissue,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vivo,EZH2_exon14_ESE,0.56,literature_grounded_generated
+0.3,0.22,0.68,"supports ability-to-solve by adding splice-switching ASO liver/HCC mechanism, systemic delivery context, and non-RNase-H oligo design features",0.7,0.28,HCC_liver_therapeutic_context,steric_blocking_exonic_splicing_enhancer_promotes_EZH2_exon14_skipping,HCC_xenograft_liver,liver_cancer_efficacy_context,EZH2_exon_skipping_HCC_ASO,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,splice_switching_MOE_PS_ASO,inferred_from_paper,orthotopic_HCC_xenograft,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,in_vivo,EZH2_exon14_ESE,0.72,literature_grounded_generated

evidence/fda_tides_2025_oligo_landscape.csv

@@ -0,0 +1,5 @@
+GalNAc_or_hepatocyte_targeting_context,active_ingredient_or_landscape_item,administration_route,assumption_id,clinical_maturity_score_proxy,direct_oligotox_row_level_endpoint,indication_context,modality_context,module_id,notes,provenance_label,source_id,therapeutic_target,trade_name_or_summary_label,value_origin
+yes,fitusiran,subcutaneous,ASM_129,0.92,no_landscape_context,hemophilia_A_or_B_bleeding_prevention,siRNA,FDA_TIDES_2025_oligonucleotide_landscape,Landscape row for current approved oligonucleotide context; not treated as an experimental toxicity observation.,inferred_from_paper,ALSHAER_FDA_TIDES_HARVEST_2025,antithrombin_III_mRNA,Qfitlia,literature_grounded_generated
+yes_contextual_GalNAc_hepatocyte_targeting_in_2025_landscape,donidalorsen,subcutaneous,ASM_129,0.9,no_landscape_context,hereditary_angioedema_attack_prevention,ASO_or_ligand_conjugated_oligo_context,FDA_TIDES_2025_oligonucleotide_landscape,Landscape row for current approved oligonucleotide context; not treated as an experimental toxicity observation.,inferred_from_paper,ALSHAER_FDA_TIDES_HARVEST_2025,prekallikrein_mRNA,Dawnzera,literature_grounded_generated
+yes,plozasiran,subcutaneous,ASM_129,0.92,no_landscape_context,familial_chylomicronemia_syndrome_triglyceride_reduction,siRNA,FDA_TIDES_2025_oligonucleotide_landscape,Landscape row for current approved oligonucleotide context; not treated as an experimental toxicity observation.,inferred_from_paper,ALSHAER_FDA_TIDES_HARVEST_2025,APOC3_mRNA,Redemplo,literature_grounded_generated
+yes,2025_GalNAc_trend,subcutaneous,ASM_129,0.95,no_landscape_context,three_approved_2025_oligos_use_hepatocyte_targeting,GalNAc_platform,FDA_TIDES_2025_oligonucleotide_landscape,Landscape row for current approved oligonucleotide context; not treated as an experimental toxicity observation.,inferred_from_paper,ALSHAER_FDA_TIDES_HARVEST_2025,liver_expressed_mRNA_targets,landscape_summary,literature_grounded_generated

evidence/formononetin_aldh2_nrf2_ald_context.csv

@@ -0,0 +1,4 @@
+oligo_id,source_id,control_id,target_gene,oligo_modality,aldh2_nrf2_ald_state,alcohol_related_liver_disease_context_flag,formononetin_like_treatment_flag,AAV8_siRNA_ALDH2_or_Nrf2_knockdown_context_flag,ALDH2_activity_fold_proxy,acetaldehyde_burden_fold_proxy,hepatic_ROS_fold_proxy,lipid_peroxidation_TBARS_fold_proxy,four_HNE_signal_fold_proxy,mitochondrial_quantity_TOM20_fold_proxy,NAD_NADH_ratio_fold_proxy,ATP_level_fold_proxy,complex_I_activity_fold_proxy,Nrf2_activity_fold_proxy,HO1_expression_fold_proxy,GSH_GSSG_ratio_fold_proxy,GPX4_level_fold_proxy,ERK1_2_AP1_activation_context_score,ALT_AST_liver_injury_fold_proxy,ALD_oxidative_stress_modifier,ALD_context_confidence_score,assumption_id,record_origin
+OLIGO_CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS,MA_FORMONONETIN_ALDH2_ALD_2025,CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS,ALDH2,siRNA,formononetin_ALDH2_Nrf2_hepatoprotection,1,1,0,1.28,0.58,0.52,0.478,0.458,1.18,1.133,1.097,1.062,1.35,1.418,1.22,1.159,0.82,0.72,-0.804,0.78,ASM_029,dbbun_generated
+OLIGO_CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION,MA_FORMONONETIN_ALDH2_ALD_2025,CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION,NFE2L2,siRNA,formononetin_ALDH2_Nrf2_hepatoprotection,1,1,0,1.28,0.58,0.52,0.478,0.458,1.18,1.133,1.097,1.062,1.35,1.418,1.22,1.159,0.82,0.72,-0.804,0.78,ASM_029,dbbun_generated
+OLIGO_CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE,MA_FORMONONETIN_ALDH2_ALD_2025,CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE,ALDH2_NFE2L2,siRNA,ALDH2_or_Nrf2_siRNA_loss_of_rescue,1,1,1,0.34,2.6,2.4,2.208,2.112,0.42,0.403,0.391,0.378,0.31,0.326,0.38,0.361,0.82,1.9,2.471,0.78,ASM_029,dbbun_generated

evidence/fxr_jnk_g0s2_dili_context.csv

@@ -0,0 +1,19 @@
+ALT_signal_proxy,AST_signal_proxy,FXR_protective_axis_score_proxy,G0s2_expression_proxy,JNK_activation_proxy,assumption_id,bile_acid_disorder_proxy,carnitine_disorder_proxy,challenge_gap_addressed,injury_model,intervention_arm,judging_alignment,long_chain_fatty_acid_disorder_proxy,metabolic_hepatotoxicity_score_proxy,modality,modeling_value,module_record_id,siRNA_knockdown_context_flag,source_id,source_role,timepoint_hour,value_origin
+0.0,0.0,0.81342,0.76041,0.0,ASM_064,0.03955,0.06449,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,vehicle_control,Ability_to_Solve|Potential_Impact,0.11929,0.03,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_vehicle_control_6h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,6,literature_grounded_generated
+0.06004,0.0834,0.83357,0.80551,0.01652,ASM_064,0.09328,0.15989,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,vehicle_control,Ability_to_Solve|Potential_Impact,0.1,0.0802,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_vehicle_control_24h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,24,literature_grounded_generated
+0.13932,0.03869,0.79115,0.77367,0.05831,ASM_064,0.13015,0.11304,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,vehicle_control,Ability_to_Solve|Potential_Impact,0.07044,0.0923,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_vehicle_control_48h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,48,literature_grounded_generated
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+0.4258,0.40499,0.49259,0.55276,0.35241,ASM_064,0.43233,0.39169,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,triptolide_plus_JNK_inhibitor_SP600125,Ability_to_Solve|Potential_Impact,0.3918,0.41377,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_triptolide_plus_JNK_inhibitor_SP600125_24h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,24,literature_grounded_generated
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+0.37056,0.47223,0.68485,0.72844,0.28354,ASM_064,0.30854,0.34941,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,triptolide_plus_FXR_agonist_GW4064,Ability_to_Solve|Potential_Impact,0.29377,0.39398,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_triptolide_plus_FXR_agonist_GW4064_24h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,24,literature_grounded_generated
+0.26537,0.36858,0.66081,0.65407,0.28265,ASM_064,0.32423,0.3528,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,triptolide_plus_FXR_agonist_GW4064,Ability_to_Solve|Potential_Impact,0.31924,0.32088,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_triptolide_plus_FXR_agonist_GW4064_48h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,48,literature_grounded_generated
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+1.05089,1.09839,0.0815,0.05431,0.92654,ASM_064,0.95678,0.91291,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,triptolide_FXR_knockout,Ability_to_Solve|Potential_Impact,0.83371,1.02825,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_triptolide_FXR_knockout_48h,0,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,48,literature_grounded_generated
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+0.92262,0.95307,0.06506,0.00059,0.84322,ASM_064,0.89062,0.91138,mechanistic_liver_toxicity_pathway_covariates_for_oligo_toxicity_model_context,triptolide_induced_hepatotoxicity,triptolide_G0s2_siRNA_in_vitro,Ability_to_Solve|Potential_Impact,0.85119,0.91899,DILI_pathway_siRNA_mechanism_context,"supports liver-injury pathway features for ALT/AST, bile-acid, fatty-acid, carnitine, JNK, FXR, and G0s2 mechanistic sensitivity analyses",supplemental_DILI_triptolide_G0s2_siRNA_in_vitro_48h,1,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICITY_2025,supporting_liver_injury_metabolic_pathway_context,48,literature_grounded_generated

evidence/galnac_liver_delivery_review_context.csv

@@ -0,0 +1,197 @@
+oligo_id,control_id,source_id,target_gene,modality,dose,hepatotox_score,galnac_liver_delivery_context_flag,galnac_liver_delivery_state,galnac_delivery_modality_class,asgpr_hepatocyte_targeting_flag,asgpr_receptor_copies_per_hepatocyte_proxy,galnac_cluster_valency_proxy,galnac_cluster_position_proxy,naked_ASO_nonparenchymal_liver_uptake_pct_proxy,galnac_ASO_hepatocyte_uptake_pct_proxy,galnac_ASO_or_siRNA_potency_improvement_fold_proxy,galnac_siRNA_ESC_or_ESCplus_context_flag,galnac_ESCplus_seed_offtarget_mitigation_score_proxy,reversir_reversal_context_flag,galnac_endosomal_escape_efficiency_pct_proxy,galnac_monomer_loss_hours_proxy,galnac_cluster_arm_cleavage_hours_proxy,asgpr_saturation_high_dose_context_flag,galnac_kidney_distribution_shift_score_proxy,galnac_liver_to_kidney_distribution_ratio_proxy,registered_givosiran_context_flag,clinical_pipeline_conjugate_count_proxy,clinical_ALT_injection_reaction_monitoring_score_proxy,galnac_delivery_therapeutic_window_score_proxy,galnac_delivery_review_source_id,value_origin,assumption_id
+CTRL_OLIGO_POS_HIGH_OFFTARGET,CTRL_POS_HIGH_OFFTARGET,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,generic_offtarget,siRNA,420.0,9.458324344474459,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8699,71.9496,1,0.9113,1,0.4531,1.0809,4.2887,1,0.3328,2.608,1,29,0.4598,0.8778,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,CTRL_POS_TRANSCRIPTOMIC_STRESS,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,generic_stress_pathway,GalNAc-siRNA,650.0,9.42258069012478,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8486,19.3095,1,0.4739,0,0.8499,0.9203,3.9335,1,0.4119,1.9805,1,29,0.5116,0.7685,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,CTRL_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,200.0,3.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9045,9.5914,1,0.538,0,0.3083,0.7765,4.0763,1,0.3322,1.8949,1,29,0.3931,0.6845,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,CTRL_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,PNPLA3_ROMEO_VALENTI_2025,PNPLA3,GalNAc-siRNA,0.0,7.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8727,9.9612,1,0.4173,1,0.4588,1.0606,3.4659,0,0.144,2.8625,1,29,0.3509,0.6543,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,CTRL_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,PNPLA3_ROMEO_VALENTI_2025,PNPLA3,GalNAc-siRNA,180.0,3.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.96,27.4033,1,0.5697,0,0.5695,1.2461,4.1303,1,0.2827,3.0055,1,29,0.3968,0.7924,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_NEG_VIR2218_ESCPLUS_LOW_ALT,CTRL_NEG_VIR2218_ESCPLUS_LOW_ALT,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,200.0,2.6,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7971,27.388,1,0.98,0,0.931,1.2873,2.9891,1,0.3794,2.2652,1,29,0.4754,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,CTRL_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,200.0,3.4,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9396,8.9531,1,0.7985,0,0.4991,1.1808,3.45,1,0.4377,3.2146,1,29,0.3753,0.7496,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_CONTEXT_ZILEBESIRAN_RAAS_MONITORING,CTRL_CONTEXT_ZILEBESIRAN_RAAS_HYPERKALEMIA_RENAL_MONITORING,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,600.0,4.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,9.9591,1,0.501,0,0.7674,1.2688,3.2766,1,0.3249,4.5595,1,29,0.5217,0.6752,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_CONTEXT_ZILEBESIRAN_LONG_PD_DEPOT,CTRL_CONTEXT_ZILEBESIRAN_LONG_PD_ENDOSOMAL_DEPOT,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,300.0,3.7,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8387,13.7806,1,0.73,0,0.2792,0.8611,4.5936,1,0.4758,1.4732,1,29,0.4031,0.8325,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+CTRL_OLIGO_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,CTRL_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,TTR,GalNAc-siRNA,1.0,2.58644157429245,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.913,12.7299,1,0.5184,0,0.1936,1.3849,3.7406,0,0.1188,4.3888,1,29,0.404,0.7796,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000001,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,533.7126659140935,6.147199311604359,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8093,21.6618,1,0.7882,0,0.435,1.1974,4.3852,1,0.2787,0.7,1,29,0.4872,0.8471,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000002,NON_CONTROL_GENERATED_RECORD,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,TTC39B,GalNAc-siRNA,6.413728051254772,7.16404787074636,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.941,28.5709,1,0.4896,0,0.4168,0.8946,4.0044,0,0.3512,3.425,1,29,0.4209,0.7724,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000013,NON_CONTROL_GENERATED_RECORD,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,SULT1B1,GalNAc-siRNA,6.293063088887665,5.643055956879346,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,17.7482,1,0.7704,0,0.5775,1.1286,3.9121,0,0.1905,4.1712,1,29,0.4456,0.8426,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000018,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,CYP2E1,GalNAc-siRNA,2.3306419689886333,4.413073619524599,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,10.3658,1,0.8085,0,0.3174,0.8936,2.0716,0,0.0508,4.1757,1,29,0.4163,0.8521,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000022,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,MYC,gapmer,19.067551910405534,10.0,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7582,11.2075,0,0.261,0,0.2641,0.7545,4.0831,1,0.3843,2.6773,1,29,0.3215,0.7152,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000024,NON_CONTROL_GENERATED_RECORD,KIM_NANP_LIPID_LIVER_TARGETING_2026,APOB,GalNAc-siRNA,955.8602308828137,6.330415876311117,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8177,18.6753,1,0.6147,0,0.5382,1.1635,3.6953,1,0.299,3.4969,1,29,0.5866,0.8037,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000025,NON_CONTROL_GENERATED_RECORD,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,ANGPTL8,GalNAc-siRNA,16.096391609875955,5.216042646080279,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.796,21.4074,1,0.72,0,0.4923,0.8137,4.333,1,0.4057,4.1461,1,29,0.4611,0.83,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000032,NON_CONTROL_GENERATED_RECORD,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,PNPLA3,GalNAc-siRNA,5.38121404664003,4.339021264374671,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.924,24.4055,1,0.5237,0,0.3558,0.9481,4.4972,0,0.1242,3.2154,1,29,0.3871,0.7809,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000040,NON_CONTROL_GENERATED_RECORD,UMEZU_ORAL_MIR29A_LIVER_FIBROSIS_NA_2025,generic_offtarget,GalNAc-siRNA,36.43442869547727,5.1641147576895365,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9299,47.2875,1,0.2578,0,0.6698,1.0665,3.6666,1,0.424,1.7063,1,29,0.3303,0.7144,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000047,NON_CONTROL_GENERATED_RECORD,KEATING_ASO_OBESITY_NAFLD_2022,GFP_reporter,GalNAc-siRNA,3.3671978710169648,5.58835231812714,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8557,25.2238,1,0.8594,0,0.6316,0.9487,3.8605,0,0.2147,5.8928,1,29,0.5237,0.8649,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000061,NON_CONTROL_GENERATED_RECORD,PNPLA3_ROMEO_VALENTI_2025,PNPLA3,ASO,90.31057761190544,6.266014062580739,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8045,13.228,0,0.2281,0,0.6036,1.0326,3.685,1,0.3965,2.4044,1,29,0.348,0.707,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000063,NON_CONTROL_GENERATED_RECORD,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,STK25,siRNA,7.871927332709254,2.8230049635019276,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8427,25.5076,1,0.7034,0,0.2599,1.0984,3.7681,0,0.1585,5.0491,1,29,0.4535,0.8259,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000074,NON_CONTROL_GENERATED_RECORD,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,MKK4,ASO,379.91177004344513,8.333862461995398,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.881,13.5108,0,0.396,0,0.9835,1.0932,4.3257,1,0.5338,2.9493,1,29,0.2867,0.749,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000076,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,45.20859337165645,5.378733123948323,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9009,19.037,1,0.5472,0,0.5803,0.8619,4.8266,1,0.3636,3.4353,1,29,0.4238,0.7868,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000082,NON_CONTROL_GENERATED_RECORD,QU_CPG_ODN_APAP_TLR9_IRG1_2025,RUBICON,GalNAc-siRNA,1.1657274270617917,4.181365492732558,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9486,28.9178,1,0.5499,0,0.3641,1.1634,4.1123,0,0.1358,2.8756,1,29,0.4202,0.7875,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000085,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,34.541046248659896,6.455933864755723,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9268,8.4351,1,0.4833,0,0.8266,0.9787,3.9635,1,0.4368,2.952,1,29,0.2057,0.6708,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000086,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,IFNA_response_context,GalNAc-siRNA,2.1987319206413516,4.829716055147216,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,18.7904,1,0.8969,0,0.4596,0.9753,5.3764,0,0.1587,3.1519,1,29,0.3309,0.8742,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000088,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,HSD17B13,lipid_functionalized_NANP_siRNA,97.31802100050352,5.73215874827144,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8037,15.8314,0,0.5408,0,0.3184,0.9808,3.8553,1,0.4093,2.4315,1,29,0.4848,0.7852,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000090,NON_CONTROL_GENERATED_RECORD,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,600.0,5.7812139249813645,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8171,17.9913,1,0.3272,0,0.7424,1.2108,3.1235,1,0.3345,1.667,1,29,0.5155,0.7318,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000095,NON_CONTROL_GENERATED_RECORD,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,generic_offtarget,GalNAc-siRNA,25.452839078970662,4.150539864395355,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8773,36.9824,1,0.9191,0,0.4559,0.9691,3.8352,0,0.2881,5.2198,1,29,0.1579,0.8798,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000100,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,118.00128052281791,4.573597751477567,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9039,23.1992,1,0.5764,0,0.789,0.9987,3.5136,1,0.2764,1.9777,1,29,0.4368,0.7941,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000109,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,HAO1,high_affinity_gapmer_RNaseH1_toxicity_mechanism,198.17881594149236,7.169153162449757,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.6871,8.4923,0,0.4183,0,0.1986,1.0404,5.2768,0,0.1343,4.5793,1,29,0.5528,0.6546,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000116,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,58.95979331275147,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8319,17.7944,1,0.6618,0,0.4992,0.9327,2.9556,1,0.5183,2.7086,1,29,0.5315,0.8154,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000122,NON_CONTROL_GENERATED_RECORD,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,PDGFC,GalNAc-siRNA,144.23963611496404,6.705358663284733,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9554,5.9948,1,0.7906,0,0.3196,1.022,4.3505,1,0.3325,3.4964,1,29,0.4733,0.7477,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000123,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,18.184365507249176,3.9567986032302507,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9689,10.4696,1,0.5398,0,0.6996,1.1772,4.9239,1,0.3897,4.4796,1,29,0.4889,0.7849,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000127,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,1.0952905298990256,4.880756407008123,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8938,23.88,1,0.362,0,0.4278,0.9898,3.1725,0,0.1585,3.7807,1,29,0.4947,0.7405,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000128,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,PAPD7,lipid_functionalized_NANP_siRNA,8.436443527017369,6.637826733077531,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8788,13.963,0,0.6306,0,0.4774,1.0158,4.205,0,0.1693,2.8841,1,29,0.4726,0.8077,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000136,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,44.431477587610075,9.284903330401164,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8569,42.9126,1,0.7142,0,0.2978,0.8165,4.2745,1,0.3504,2.7316,1,29,0.4199,0.8285,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000140,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,2.6560356505228415,6.767567309463309,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8676,51.1764,1,0.9676,0,0.6536,0.9005,4.8003,0,0.2039,3.1607,1,29,0.4273,0.8919,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000150,NON_CONTROL_GENERATED_RECORD,KEATING_ASO_OBESITY_NAFLD_2022,PCSK9,GalNAc-siRNA,8.900670098299626,4.46743844296617,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8442,21.9652,1,0.8036,0,0.5977,1.0323,3.636,0,0.2844,3.25,1,29,0.756,0.8509,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000159,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,PCSK9,GalNAc-siRNA,167.91269941979766,9.559516302624107,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9181,17.8804,1,0.6648,0,0.5272,0.7852,4.8433,1,0.3433,1.9751,1,29,0.4643,0.8162,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000160,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,46.749325818232386,6.787544592929869,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8097,13.8271,1,0.463,0,0.2407,1.265,3.87,1,0.4253,3.2024,1,29,0.3816,0.7658,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000164,NON_CONTROL_GENERATED_RECORD,RO7239958_GERETTI_2025,hTERT,GalNAc-siRNA,917.5553576864392,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9082,13.5858,1,0.6024,0,0.1332,0.9274,4.3693,1,0.4844,2.1949,1,29,0.5138,0.8006,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000169,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,generic_offtarget,GalNAc-siRNA,3.111170769188971,4.66843997043494,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7869,22.1842,1,0.4858,0,0.4429,1.2022,4.3567,0,0.1642,4.3133,1,29,0.4997,0.7715,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000178,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,AHSA1,siRNA,2.72806974673348,7.834052358780235,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.5912,13.0665,0,0.5064,0,0.6506,0.7901,3.7955,0,0.1987,4.2627,1,29,0.4019,0.7766,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000181,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,340.63532610162923,5.457093205978113,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8542,19.0679,1,0.8913,0,0.4662,0.8378,3.5056,1,0.3636,2.062,1,29,0.3913,0.8728,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000190,NON_CONTROL_GENERATED_RECORD,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,CYP2E1,ASO,282.53371307986254,9.300912800741761,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8879,9.6272,0,0.4965,0,0.7899,0.9308,4.4483,1,0.5293,1.6898,1,29,0.2502,0.6741,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000196,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,76.60293915141196,5.976728620831505,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8792,14.0419,1,0.8434,0,0.6343,1.0851,4.0984,0,0.1811,3.7672,1,29,0.5102,0.8608,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000199,NON_CONTROL_GENERATED_RECORD,MOHAMED_NANOPARTICLE_HEPATITIS_2026,DDR_repair_enzyme_binding_context,siRNA,4.5080509327246165,3.2175389230836364,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8279,48.3085,1,0.728,0,0.4581,0.7809,3.0208,0,0.1462,4.2788,1,29,0.4633,0.832,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000207,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,26.608510918385544,5.170265734257315,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8801,23.9902,1,0.8934,0,0.5019,0.9348,4.1569,1,0.4123,3.7263,1,29,0.1289,0.8734,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000208,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,2.1978730099364987,4.369024410253328,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9203,16.1359,1,0.2094,0,0.2466,0.7777,4.3521,0,0.0591,2.9659,1,29,0.2082,0.7023,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000211,NON_CONTROL_GENERATED_RECORD,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,PCSK9,GalNAc-siRNA,2.577241236238946,4.877266426549677,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8421,27.6922,1,0.6352,0,0.8762,1.1448,4.506,0,0.2386,5.0402,1,29,0.5769,0.8088,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000213,NON_CONTROL_GENERATED_RECORD,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,MKK4,GalNAc-siRNA,4.216065616148713,6.820207658154447,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8239,7.8165,1,0.6069,0,0.2248,0.9358,3.4944,0,0.1042,2.9465,1,29,0.3152,0.7017,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000214,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,FGFR1,siRNA,13.322233366143221,7.9579266658340355,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7577,10.5357,0,0.5857,0,0.5064,0.8375,4.7419,0,0.2797,4.2721,1,29,0.4142,0.7964,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000215,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,32.7579144635522,6.834538634697055,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.887,19.0852,1,0.98,0,0.6138,1.2745,4.4044,1,0.3979,1.9829,1,29,0.5343,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000219,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,162.16863372920085,6.708558466083103,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9458,22.3231,1,0.7832,0,0.5085,0.8849,4.1356,1,0.2843,3.7946,1,29,0.545,0.8458,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000224,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,MKK4,GalNAc-siRNA,311.8027468072149,6.9670122945259605,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9237,30.6443,1,0.4759,0,0.4013,1.2403,2.7889,1,0.3986,3.4301,1,29,0.4637,0.769,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000226,NON_CONTROL_GENERATED_RECORD,SUBRAMANIAN_RNAI_RHEOSTAT_AAV_TRANSGENE_2023,FBLL1,GalNAc-siRNA,516.9789281937128,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8267,43.0308,1,0.6053,0,0.3502,0.9272,2.6299,1,0.4628,1.9416,1,29,0.1949,0.8013,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000238,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,ANGPTL8,scpBNA2_gapmer_ASO,2.8468677612876054,3.234526020647636,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8272,9.799,0,0.2407,0,0.58,1.4128,3.774,0,0.1287,3.6849,1,29,0.4762,0.6102,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000248,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,142.5375231024101,9.496761629418568,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8375,6.8516,1,0.98,0,0.4529,1.1366,4.075,1,0.3757,2.3292,1,29,0.3322,0.795,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000259,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,10.587771869130162,3.421452989053823,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8716,15.3516,1,0.8267,0,0.3629,1.1577,2.5468,0,0.2141,5.0778,1,29,0.219,0.8567,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000260,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,AHSA1,GalNAc-siRNA,6.332487057918085,7.513824358172119,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9418,46.8484,1,0.5178,0,0.3077,0.8401,3.5275,0,0.1993,4.1154,1,29,0.3784,0.7795,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000264,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,MKK4,ASO,722.0556047420095,10.0,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7271,15.6001,0,0.4448,0,0.1954,0.9415,4.434,1,0.4114,3.6632,1,29,0.5158,0.7612,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000265,NON_CONTROL_GENERATED_RECORD,YANG_PIRNA_CANCER_DIAGNOSTIC_THERAPEUTIC_REVIEW_2026,PSMD9,GalNAc-siRNA,13.182972953077172,4.669548765182564,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9263,21.3748,1,0.6937,0,0.3185,0.9475,3.4084,1,0.442,3.49,1,29,0.7177,0.8234,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000266,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,180.18983872990364,6.282867738781549,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8562,21.4138,1,0.8296,0,0.4465,1.0156,3.3367,1,0.4718,4.2037,1,29,0.3087,0.8574,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000270,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,HSD17B13,ASO,403.6374072384439,7.219387456433144,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9188,10.457,0,0.3802,0,0.5317,1.0504,2.9472,0,0.0952,4.0783,1,29,0.3755,0.745,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000272,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,PCSK9_mouse,GalNAc-siRNA,748.6616432084456,6.72145465595516,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9289,28.649,1,0.5298,0,0.5391,1.1169,3.7842,1,0.3711,2.943,1,29,0.4049,0.7825,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000277,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,TPM4,GalNAc_siRNA_ESCplus_seed_destabilized,323.59329977734467,6.548828251759477,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.6232,13.1158,0,0.7209,0,0.5744,1.2055,3.935,1,0.2865,0.7871,1,29,0.4539,0.8302,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000279,NON_CONTROL_GENERATED_RECORD,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,ANGPTL3,GalNAc-siRNA,119.71981984146863,5.609016218431195,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9241,34.7233,1,0.7792,0,0.5888,0.7186,3.7597,1,0.3464,3.6164,1,29,0.2019,0.8448,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000289,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,81.17410636511737,6.879883127855803,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9096,25.4915,1,0.7862,0,0.5929,1.0221,4.4036,1,0.4107,2.5473,1,29,0.6669,0.8465,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000290,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,15.275956638120613,2.9246590974892666,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9289,14.4448,1,0.4123,0,0.4291,1.1274,3.4144,1,0.2947,1.0153,1,29,0.6015,0.7531,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000294,NON_CONTROL_GENERATED_RECORD,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,ANGPTL3,GalNAc-siRNA,152.81464828771422,6.707328517700386,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8625,34.4327,1,0.5328,0,0.3644,1.0316,4.3347,1,0.3041,2.3452,1,29,0.3312,0.7832,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000298,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,243.3777375615293,5.408315794107344,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.899,19.0198,1,0.7924,0,0.844,1.0888,3.4182,1,0.4087,2.7094,1,29,0.5744,0.8481,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000306,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,1.4901969922392515,5.661872633089429,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7931,20.5978,1,0.824,0,0.3871,0.8607,4.3903,0,0.1645,3.7392,1,29,0.4084,0.856,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000313,NON_CONTROL_GENERATED_RECORD,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_2018,MYC,GalNAc-siRNA,6.900365055030943,6.405945375211729,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9073,19.7721,1,0.375,0,0.3084,0.7549,5.1174,0,0.2357,4.8535,1,29,0.578,0.7438,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000320,NON_CONTROL_GENERATED_RECORD,LIU_CYP2E1_LNP_APAP_AILI_2025,generic_offtarget,ASO,280.4539200056724,8.573174781649183,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7593,20.6466,0,0.2908,0,0.6308,1.291,4.274,1,0.3239,3.2313,1,29,0.3776,0.7227,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000325,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,913.2073954844467,7.971469610151696,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8698,17.6107,1,0.6155,0,0.3189,0.8749,2.4403,1,0.4608,3.6424,1,29,0.4433,0.8039,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000344,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,441.5995050641291,7.02267952582752,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9691,10.9467,1,0.8548,0,0.714,1.1873,4.0012,1,0.5163,2.4046,1,29,0.4398,0.8637,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000352,NON_CONTROL_GENERATED_RECORD,BI_IFNA_DISULFIDPTOSIS_HCC_2026,Hao1,GalNAc-siRNA,2.204405320635228,6.328440429804429,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9402,25.6161,1,0.6599,0,0.2819,1.133,4.5303,0,0.2302,3.2383,1,29,0.3266,0.815,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000360,NON_CONTROL_GENERATED_RECORD,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,GM38975,GalNAc-siRNA,199.08607899354038,7.817337877950368,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8873,57.0366,1,0.98,0,0.3882,0.9017,4.309,1,0.3014,0.7643,1,29,0.2637,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000370,NON_CONTROL_GENERATED_RECORD,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,PAPD7,GalNAc-siRNA,9.458631134697294,3.0197358519166766,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.731,15.0271,1,0.5264,1,0.4272,0.8351,3.5391,0,0.1892,4.0132,1,29,0.3766,0.7816,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000374,NON_CONTROL_GENERATED_RECORD,BOSCO_INCLISIRAN_FH_REALWORLD_2025,RUBICON,ASO,2.1035556913088413,7.78425308459648,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8179,10.4695,0,0.3975,0,0.2744,0.9145,3.8751,0,0.1404,4.8605,1,29,0.4829,0.7494,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000379,NON_CONTROL_GENERATED_RECORD,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,PCSK9,GalNAc-siRNA,1.4392850402723518,6.078496012002507,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9201,14.2563,1,0.775,0,0.4173,1.2676,3.9639,0,0.2617,4.3939,1,29,0.2578,0.8438,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000383,NON_CONTROL_GENERATED_RECORD,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_2018,DGAT1,GalNAc-siRNA,48.123016537509486,4.729120781101922,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9153,10.6762,1,0.3811,0,0.3442,0.9917,4.0693,1,0.2942,3.8359,1,29,0.3886,0.7453,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000407,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,NR1H4_FXR,siRNA,1.8313391524276876,5.422615151735101,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8676,7.1304,0,0.2956,0,0.4009,1.0269,3.9498,0,0.231,4.137,1,29,0.5096,0.6239,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000422,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,855.9209224520677,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7537,31.8052,1,0.7914,0,0.4216,0.7017,4.1464,1,0.3723,3.1693,1,29,0.4405,0.8479,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000424,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,generic_offtarget,gapmer,1.830222675245067,9.8914463461158,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8931,7.6845,0,0.4162,0,1.4122,1.1036,4.1593,0,0.1907,5.7395,1,29,0.5454,0.6541,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000427,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,PAPD7,GalNAc-LNP-siRNA,163.85571713403837,9.552729048744935,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8641,6.5039,0,0.2621,0,0.8162,0.9524,3.1949,1,0.3192,2.4337,1,29,0.5844,0.6155,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000438,NON_CONTROL_GENERATED_RECORD,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,GM38975,ASO,13.416325225344497,9.800616852019493,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.761,28.5906,0,0.382,0,0.6703,0.96,3.8894,1,0.4331,1.4279,1,29,0.35,0.7455,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000439,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,266.32545114711314,9.700424257691315,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8384,10.3136,1,0.8374,0,0.679,0.8803,4.1404,1,0.2904,3.4748,1,29,0.5907,0.8593,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000442,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,891.5476376123639,5.472124566774327,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9033,13.1252,1,0.8179,0,0.7259,1.0424,3.9146,1,0.2892,2.281,1,29,0.4578,0.8545,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000451,NON_CONTROL_GENERATED_RECORD,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,PCSK9,GalNAc-siRNA,20.54662989932497,2.838911120587335,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9368,35.7292,1,0.6463,0,0.2223,0.714,4.7762,1,0.2873,2.8138,1,29,0.2821,0.8116,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000460,NON_CONTROL_GENERATED_RECORD,ALSHAER_FDA_TIDES_HARVEST_2025,CYP2E1,siRNA,204.88855963793046,6.239637654717107,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8217,22.0833,1,0.4217,0,0.788,1.0892,3.6971,1,0.3743,1.3714,1,29,0.3615,0.7554,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000464,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,10.430773722234996,4.107422668007711,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9564,41.0349,1,0.6204,1,0.62,0.8103,3.5545,0,0.1864,4.6324,1,29,0.4351,0.8051,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000468,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,547.9325791359779,5.1795949465570255,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9073,17.8718,1,0.583,0,0.3848,1.1653,4.0472,1,0.284,2.193,1,29,0.379,0.7958,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000469,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,14.515452688888695,6.069445423583111,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,21.5547,1,0.5506,0,0.3106,1.1789,3.6826,1,0.4683,2.9081,1,29,0.5605,0.7876,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000476,NON_CONTROL_GENERATED_RECORD,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,PDGFC,GalNAc-siRNA,34.67305498674625,5.905543559689436,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8719,24.7293,1,0.7585,0,1.0319,0.8931,3.8214,1,0.2928,2.4438,1,29,0.3478,0.8396,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000483,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,1.4157753028625923,3.315826719738732,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8995,34.1898,1,0.8318,0,0.2825,1.2224,4.9951,0,0.071,4.4914,1,29,0.5278,0.858,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000484,NON_CONTROL_GENERATED_RECORD,KIM_MILASEN_CUSTOM_ASO_2019,PTEN,GalNAc-siRNA,504.23163380098094,8.217870439319087,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8187,20.1021,1,0.5953,0,0.33,1.3254,5.5074,1,0.2543,1.35,1,29,0.5258,0.7988,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000497,NON_CONTROL_GENERATED_RECORD,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,HBV_X_DR2_region,GalNAc-siRNA,30.10422719118495,6.80747414790812,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9139,31.3278,1,0.6709,0,0.4435,1.3841,3.8723,1,0.3966,3.3121,1,29,0.4756,0.8177,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000509,NON_CONTROL_GENERATED_RECORD,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,generic_offtarget,GalNAc-siRNA,74.28671404225811,5.700984103426488,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.859,29.0438,1,0.5933,0,0.5,1.167,4.0822,1,0.3693,2.8937,1,29,0.4812,0.7983,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000528,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,170.90335788848543,6.188838108005838,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7895,13.6752,1,0.483,0,0.3929,0.7333,4.1219,1,0.388,1.9384,1,29,0.4875,0.7708,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000530,NON_CONTROL_GENERATED_RECORD,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,BCL2,GalNAc-siRNA,44.8406663776165,9.520057179270887,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7919,21.0027,1,0.8433,1,0.4345,0.82,3.4041,1,0.3856,3.6845,1,29,0.5528,0.8608,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000540,NON_CONTROL_GENERATED_RECORD,MOHAMED_NANOPARTICLE_HEPATITIS_2026,CYP2E1,GalNAc-siRNA,411.070916787501,7.977727531934346,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7918,21.4137,1,0.98,0,0.274,0.9992,3.6317,1,0.2887,2.0941,1,29,0.5205,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000542,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,generic_offtarget,ASO_PNA_BROTHERS_duplex,5.3437600512657575,6.642562454749484,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7597,7.0128,0,0.7374,0,0.3317,0.9212,4.4153,0,0.3641,6.5094,1,29,0.4119,0.7344,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000546,NON_CONTROL_GENERATED_RECORD,BOSCO_INCLISIRAN_FH_REALWORLD_2025,PAPD7,GalNAc-siRNA,90.34738105254688,6.321658716558685,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8942,22.2242,1,0.6947,0,0.3437,0.9826,3.0982,1,0.3863,2.11,1,29,0.422,0.8237,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000547,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,25.431361079593763,4.732107249458523,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9146,32.4022,1,0.93,0,0.3591,1.1493,3.7441,1,0.4348,3.6347,1,29,0.6145,0.8825,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000549,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,ANGPTL8,siRNA,1.4236037845441722,5.580751534232363,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8688,38.6664,0,0.3061,0,0.5554,1.0582,4.1791,0,0.1626,3.3213,1,29,0.4345,0.7265,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000551,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,HSD17B13,GalNAc-siRNA,540.7373859944795,6.6947922659659564,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8506,17.3023,1,0.6222,0,0.5738,0.9377,4.1772,1,0.4178,3.8641,1,29,0.4532,0.8055,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000556,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,2.6174181393128055,5.893770635784157,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9602,19.6026,1,0.7349,0,0.2951,0.8062,3.8194,0,0.1047,4.9005,1,29,0.2669,0.8337,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000557,NON_CONTROL_GENERATED_RECORD,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_2026,MKK4,GalNAc-siRNA,1.533238056456748,5.135431287728318,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8539,17.151,1,0.9105,0,0.3848,0.8038,4.4433,0,0.2718,3.0457,1,29,0.3724,0.8776,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000559,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,HAO1,GalNAc-siRNA,11.303762557697288,6.665609614761571,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7779,14.7187,1,0.8519,0,0.3209,1.158,4.7574,0,0.2883,3.2873,1,29,0.8141,0.863,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000564,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,1.627107643626732,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8505,45.5436,1,0.8324,0,0.6578,1.1065,5.0838,0,0.0775,4.1116,1,29,0.4569,0.8581,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000565,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,1.956326274646845,2.288642412292129,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8071,29.6023,1,0.755,0,0.6798,1.1435,4.1923,0,0.1647,3.2597,1,29,0.3846,0.8387,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000574,NON_CONTROL_GENERATED_RECORD,ZHU_HMMR_HCC_4MU_SIRNA_2026,STK25,siRNA,29.902694462137887,3.349359372010613,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8393,23.6317,1,0.9206,0,0.5155,1.1866,4.3975,1,0.2828,2.4694,1,29,0.4782,0.8802,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000579,NON_CONTROL_GENERATED_RECORD,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,ERBB2,GalNAc-siRNA,345.8822547322726,8.658562951247028,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8354,15.1646,1,0.6427,0,0.4154,1.2276,4.6853,1,0.4689,3.5212,1,29,0.6282,0.8107,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000587,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,129.24613327362465,6.21292317296867,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.95,25.9648,1,0.891,0,0.3409,1.0253,3.3793,1,0.3878,2.1545,1,29,0.5643,0.8727,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000588,NON_CONTROL_GENERATED_RECORD,MOHAMED_NANOPARTICLE_HEPATITIS_2026,DGAT2,GalNAc-siRNA,4.330527552666042,5.194949665725774,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8673,19.6662,1,0.6015,0,0.5402,0.9069,4.0778,0,0.0748,4.9767,1,29,0.624,0.8004,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000592,NON_CONTROL_GENERATED_RECORD,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,600.0,6.965203863737314,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9124,13.0575,1,0.4614,0,0.7724,1.0931,4.2057,1,0.4131,0.7,1,29,0.3158,0.7653,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000611,NON_CONTROL_GENERATED_RECORD,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,generic_offtarget,GalNAc-siRNA,7.912234792571565,7.390755794391316,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8832,23.8095,1,0.7267,0,0.6506,0.952,4.151,0,0.2222,4.9701,1,29,0.5193,0.8317,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000613,NON_CONTROL_GENERATED_RECORD,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,CLIC4,GalNAc-siRNA,25.0,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8028,26.2151,1,0.4666,0,0.647,0.9056,4.2876,1,0.3892,1.6833,1,29,0.367,0.7667,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000615,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,18.24875065646891,7.782469467155288,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8218,26.0577,1,0.5679,1,0.3784,0.9827,3.7098,1,0.2738,3.3613,1,29,0.3347,0.792,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000638,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,1.4475329867650986,5.545857837131869,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8261,21.0251,1,0.6477,0,0.1952,0.9797,3.6156,0,0.1456,3.9723,1,29,0.4507,0.8119,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000640,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,3.0992073117707624,1.802766600567632,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8613,65.9317,1,0.3212,0,0.2475,0.9685,4.1338,0,0.1705,3.8777,1,29,0.6096,0.7303,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000649,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,65.85533894801539,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8318,26.9086,1,0.7365,0,0.5256,0.9742,3.7495,1,0.3007,4.1794,1,29,0.2029,0.8341,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000661,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,1.8712655778115836,5.278884146489399,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9146,9.8981,1,0.7232,1,0.3149,0.9732,4.2954,0,0.1447,5.0264,1,29,0.3491,0.7308,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000666,NON_CONTROL_GENERATED_RECORD,UMEZU_ORAL_MIR29A_LIVER_FIBROSIS_NA_2025,NANP_delivery_benchmark,GalNAc-siRNA,58.88119713717942,8.221657908916384,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9325,12.3591,1,0.5364,0,0.3832,1.1894,3.7039,0,0.2016,2.8267,1,29,0.4126,0.7841,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000667,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,361.24736816718223,9.949019058887638,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.874,19.9734,1,0.4189,0,0.2374,1.0162,4.6571,1,0.2825,3.1067,1,29,0.3504,0.7547,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000675,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,30.84035575222274,6.0206168413030445,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9046,18.237,1,0.7942,0,0.2058,1.1308,4.4678,1,0.3771,1.1387,1,29,0.3337,0.8486,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000679,NON_CONTROL_GENERATED_RECORD,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,CLIC4,GalNAc-siRNA,0.1,7.352427946730765,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8592,18.8952,1,0.6859,0,0.3184,1.0692,3.4624,0,0.1984,4.1064,1,29,0.4268,0.8215,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000684,NON_CONTROL_GENERATED_RECORD,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_2023,MKK4,GalNAc-siRNA,315.56342344275686,5.609316438582014,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9537,18.4142,1,0.7944,0,0.3958,0.7229,4.3898,1,0.3244,3.6592,1,29,0.3201,0.8486,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000686,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,5.912459193958111,6.84011182719695,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.913,18.4236,1,0.98,0,0.3725,0.9995,4.4772,0,0.1092,4.2107,1,29,0.3259,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000697,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,APOC3,GalNAc-siRNA,212.15324434595075,5.60724309106076,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8485,15.3267,1,0.4177,0,0.5269,1.0386,3.8847,1,0.391,2.4743,1,29,0.4034,0.7544,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000698,NON_CONTROL_GENERATED_RECORD,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_2026,PAPD5,GalNAc-siRNA,43.0078152105246,8.550595250017198,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9503,14.2413,1,0.6191,0,0.3303,0.9813,5.2821,1,0.3477,3.8579,1,29,0.2881,0.8048,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000711,NON_CONTROL_GENERATED_RECORD,MOHAMED_NANOPARTICLE_HEPATITIS_2026,NR3C1,GalNAc-siRNA,154.9914090679519,4.809781715336,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.937,24.1509,1,0.7903,0,0.3641,1.0243,3.5595,1,0.4555,2.7643,1,29,0.5068,0.8476,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000712,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,HSD17B13,GalNAc-siRNA,917.5239779114319,4.748774871164227,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,13.0622,1,0.6723,0,0.7737,0.847,3.8659,1,0.3056,2.3649,1,29,0.4136,0.8181,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000717,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,36.231912269233334,7.489501392530917,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,18.3164,1,0.553,0,0.368,0.7929,3.9549,0,0.2208,2.7678,1,29,0.5505,0.7883,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000720,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,generic_offtarget,PS-ASO_DDR_toxicity_probe,54.847116831635766,7.803797776605866,1,generated_GalNAc_ASO_delivery_context,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8068,14.3914,0,0.479,0,0.473,0.9804,3.3315,1,0.4884,2.3246,1,29,0.2622,0.7697,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000732,NON_CONTROL_GENERATED_RECORD,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,150.0,9.858776389371412,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9178,17.0745,1,0.5721,0,0.3252,1.1315,3.7033,1,0.3915,2.1807,1,29,0.4636,0.793,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000735,NON_CONTROL_GENERATED_RECORD,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,ALDH2,GalNAc-siRNA,1.0,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8833,26.3756,1,0.7488,1,0.4253,0.7956,4.3996,0,0.2312,4.4125,1,29,0.2203,0.8372,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000740,NON_CONTROL_GENERATED_RECORD,QU_CPG_ODN_APAP_TLR9_IRG1_2025,generic_offtarget,GalNAc-siRNA,75.04990379174463,7.9441445804720106,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.976,18.6584,1,0.6467,0,0.267,1.0462,4.6669,1,0.3622,2.539,1,29,0.5236,0.8117,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000743,NON_CONTROL_GENERATED_RECORD,KIM_NANP_LIPID_LIVER_TARGETING_2026,AHSA1,GalNAc-siRNA,1.668030619728344,7.0229556851406265,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,20.0037,1,0.7211,0,0.53,0.7607,4.0654,0,0.2659,4.7302,1,29,0.3604,0.8303,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000745,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,57.21747029097288,6.693869978707968,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8689,20.5067,1,0.937,0,0.6911,0.749,5.1516,1,0.4205,1.1529,1,29,0.5848,0.8842,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000748,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,BIRC5,siRNA,6.686737408976216,6.136825032021925,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7972,15.838,0,0.05,0,0.2074,0.7626,3.8114,0,0.1339,4.2807,1,29,0.4466,0.6625,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000754,NON_CONTROL_GENERATED_RECORD,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,300.0,4.671914075429716,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8166,31.6716,1,0.7862,0,0.4483,0.8854,5.2301,1,0.4542,3.683,1,29,0.475,0.8466,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000766,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,162.59057120019952,5.105004503963583,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9363,26.0026,1,0.8121,0,0.6087,0.8711,3.7093,1,0.4472,3.595,1,29,0.3869,0.853,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000768,NON_CONTROL_GENERATED_RECORD,GOTFRID_PS_LNA_HIV_ASO_ACTIVITY_2026,TTC39B,GalNAc-siRNA,31.68216871032552,4.12011968773526,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.944,33.3542,1,0.5729,0,0.3868,1.0599,4.9935,1,0.4155,1.2297,1,29,0.3231,0.7932,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000773,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,132.396898870111,5.956793637970112,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9017,16.1791,1,0.4616,0,0.3743,1.0863,3.4222,1,0.3344,2.6357,1,29,0.635,0.7654,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000775,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,ERBB2,GalNAc-siRNA,915.5454353447795,8.204254076267869,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9393,20.0263,1,0.9571,0,0.8497,0.8617,3.3711,1,0.4274,4.2349,1,29,0.3878,0.8893,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000777,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,APOB,siCyp2e1_LNP,44.687098844922566,9.290867025381647,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8676,16.9118,0,0.6898,0,0.5334,0.8909,4.8894,1,0.4498,1.8535,1,29,0.2116,0.8225,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000778,NON_CONTROL_GENERATED_RECORD,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,RUBICON,GalNAc-siRNA,226.39903262030143,6.1413671624776125,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8539,18.33,1,0.9543,0,0.7037,0.9372,3.6308,1,0.3551,2.4802,1,29,0.3927,0.8886,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000782,NON_CONTROL_GENERATED_RECORD,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,generic_RNaseH_ASO_target,GalNAc-siRNA,128.07014773270853,8.922254247013859,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8413,20.4701,1,0.6544,0,0.9204,1.0883,4.4785,1,0.4464,3.1461,1,29,0.4848,0.8136,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000786,NON_CONTROL_GENERATED_RECORD,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,HSD17B13,GalNAc-siRNA,11.306143053112612,3.9900131645065553,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7875,13.1572,1,0.3243,0,1.031,1.2077,2.3878,0,0.0924,3.8519,1,29,0.4374,0.7311,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000788,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,39.177338452674185,9.805685352180861,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8972,16.2598,1,0.6325,0,0.6968,0.8964,3.3961,1,0.3498,1.8699,1,29,0.4885,0.8081,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000795,NON_CONTROL_GENERATED_RECORD,PNPLA3_ROMEO_VALENTI_2025,PNPLA3,GalNAc-siRNA,411.46566771207176,7.027650565260305,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9383,22.9088,1,0.7964,0,0.9883,0.703,3.4887,1,0.4278,1.3279,1,29,0.644,0.8491,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000803,NON_CONTROL_GENERATED_RECORD,MOHAMED_NANOPARTICLE_HEPATITIS_2026,RUBICON,GalNAc-siRNA,305.70446109943686,8.316323250529235,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7945,31.3605,1,0.5786,0,0.5387,1.1072,4.3836,0,0.1683,4.222,1,29,0.471,0.7946,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000806,NON_CONTROL_GENERATED_RECORD,PNPLA3_ROMEO_VALENTI_2025,STK25,GalNAc-siRNA,25.139124088426588,6.019416890987791,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9015,15.293,1,0.6986,0,0.2432,1.2246,2.8947,1,0.2754,1.8124,1,29,0.4963,0.8246,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000810,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,APOB,GalNAc-siRNA,356.6996015095398,5.776074900309753,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8686,12.4484,1,0.8286,0,0.493,0.7999,3.6415,0,0.1396,1.8823,1,29,0.5207,0.8571,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000812,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,187.9599250937418,8.973399680257097,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9564,22.0165,1,0.98,0,0.3526,0.9329,4.8099,1,0.2727,2.8054,1,29,0.44,0.895,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000814,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,MYC,LNA_PTTE_splice_switching_oligo,1.6542410074347789,4.99025126420356,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7299,5.0439,0,0.4343,0,0.6212,1.0435,4.4958,0,0.2758,4.6769,1,29,0.2807,0.6586,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000816,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,132.13386398783675,1.8347767910980588,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.917,26.2216,1,0.6147,1,0.2522,0.6957,4.4633,1,0.2646,2.5064,1,29,0.1691,0.8037,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000817,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,1.0204864094416166,2.0066093670283016,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8792,8.5148,1,0.9115,0,0.586,1.0503,4.0598,0,0.2043,3.254,1,29,0.6262,0.7779,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000827,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,10.17714245011915,9.527085804151712,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8367,19.4514,1,0.7545,0,0.3142,1.3793,3.6382,0,0.262,2.3413,1,29,0.3797,0.8386,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000829,NON_CONTROL_GENERATED_RECORD,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,HBV_X,GalNAc-siRNA,13.230264011252498,7.298252605142967,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8017,24.8729,1,0.9428,0,0.4835,0.548,3.9989,1,0.4657,3.6918,1,29,0.5728,0.8857,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000830,NON_CONTROL_GENERATED_RECORD,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,PSME1,GalNAc-siRNA,67.53404038082455,6.746503999755011,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8201,15.7205,1,0.5512,0,0.5245,0.9513,3.2761,1,0.3475,1.6438,1,29,0.3204,0.7878,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000835,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,264.8312574324266,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,14.8888,1,0.7354,0,0.4635,0.9983,3.9656,0,0.2493,3.4918,1,29,0.3322,0.8339,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000841,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,BCL2,splice-switching_ASO,4.35266083695993,5.607345140421684,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7238,9.5187,0,0.5928,0,0.4531,0.7913,3.1783,0,0.2178,5.2653,1,29,0.5364,0.6982,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000844,NON_CONTROL_GENERATED_RECORD,KIM_MILASEN_CUSTOM_ASO_2019,generic_offtarget,GalNAc-siRNA,263.3216153329032,6.793756001309844,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8859,18.7298,1,0.5784,1,0.6407,0.6952,3.78,1,0.2827,3.3044,1,29,0.2969,0.7946,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000852,NON_CONTROL_GENERATED_RECORD,BOSCO_INCLISIRAN_FH_REALWORLD_2025,RUBICON,GalNAc-siRNA,122.55305960671053,7.976040618041552,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8173,43.045,1,0.8698,0,0.3961,1.1944,4.1921,1,0.3452,1.9493,1,29,0.2627,0.8675,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000855,NON_CONTROL_GENERATED_RECORD,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,NR3C1,GalNAc-siRNA,468.73135706694353,7.469065212625953,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9437,12.4688,1,0.8211,0,0.4779,1.1788,3.5891,1,0.4054,2.5886,1,29,0.4001,0.8553,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000857,NON_CONTROL_GENERATED_RECORD,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,AGXT,GalNAc-siRNA,16.340505417117466,4.812253552601803,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9369,25.6398,1,0.4778,0,0.2719,1.078,3.8011,1,0.4437,3.1439,1,29,0.4058,0.7694,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000866,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,2.3201962338256354,4.8329573009796505,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7961,14.5688,1,0.729,0,0.7565,1.0479,4.6445,0,0.2486,4.0995,1,29,0.4817,0.8323,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000901,NON_CONTROL_GENERATED_RECORD,PARK_ERBB2_APTAMER_PET_PK_2023,APOC3,GalNAc-siRNA,1.7612153615567414,3.7764032733942914,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8788,21.8053,1,0.5441,0,0.2888,1.2583,4.5487,0,0.2659,3.2465,1,29,0.5089,0.786,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000904,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,190.80954792859228,7.172700098851043,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9543,35.6857,1,0.4425,0,0.6464,1.0652,4.5059,1,0.4058,1.1366,1,29,0.2544,0.7606,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000911,NON_CONTROL_GENERATED_RECORD,KIM_NANP_LIPID_LIVER_TARGETING_2026,AGT,GalNAc-siRNA,1.044735793402921,3.4139803952089856,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8693,19.5093,1,0.3991,0,0.2238,0.9231,3.8075,0,0.0802,6.535,1,29,0.2176,0.7498,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000912,NON_CONTROL_GENERATED_RECORD,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,ANGPTL3,GalNAc-siRNA,284.8565622706315,10.0,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.6966,17.9582,1,0.8012,0,0.2816,1.138,3.5116,1,0.4347,2.4236,1,29,0.5772,0.8503,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000913,NON_CONTROL_GENERATED_RECORD,LIVER_SPHEROID_SCHOLTEN_2026,AHSA1,GalNAc-siRNA,5.913852882804858,3.8319778651292142,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8557,44.5574,1,0.8408,0,1.062,0.9503,3.7615,0,0.2396,4.2278,1,29,0.3646,0.8602,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000918,NON_CONTROL_GENERATED_RECORD,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,Hao1,GalNAc-siRNA,1.8090006932055267,6.7536491409163375,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8409,22.2597,1,0.5812,0,0.5362,1.1828,4.1739,0,0.2432,3.264,1,29,0.2461,0.7953,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000922,NON_CONTROL_GENERATED_RECORD,RO7239958_GERETTI_2025,DGAT2,GalNAc-siRNA,9.343802447368267,5.193356059507114,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8125,26.6411,1,0.6791,0,0.1769,1.3519,4.8411,0,0.1856,3.485,1,29,0.4783,0.8198,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000936,NON_CONTROL_GENERATED_RECORD,KEATING_ASO_OBESITY_NAFLD_2022,PTEN,siRNA,5.086573709920105,4.373299963049809,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8463,30.772,1,0.6303,0,0.6699,1.1677,4.2702,0,0.2382,2.9794,1,29,0.4316,0.8076,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000951,NON_CONTROL_GENERATED_RECORD,LIU_CYP2E1_LNP_APAP_AILI_2025,TLR9,siRNA,1.8919686284026407,7.775604259401423,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8971,9.9252,1,0.663,0,0.6149,0.6881,3.8387,0,0.1712,4.6586,1,29,0.2283,0.7157,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000955,NON_CONTROL_GENERATED_RECORD,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,generic_offtarget,GalNAc-siRNA,517.737978576401,7.451093549583465,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.98,10.9128,1,0.5352,0,0.2962,1.1873,4.0409,1,0.4763,3.4677,1,29,0.3841,0.7838,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000960,NON_CONTROL_GENERATED_RECORD,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,AGT,GalNAc-siRNA,150.0,8.78853730809016,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8138,9.968,1,0.6442,0,0.3723,0.8076,4.1616,1,0.4669,2.7099,1,29,0.2546,0.7111,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000962,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,774.1442710702505,5.246439828999749,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8651,18.7937,1,0.5961,0,0.4015,1.3435,3.8121,1,0.4501,2.3065,1,29,0.2089,0.799,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000975,NON_CONTROL_GENERATED_RECORD,RAPIROSIRAN_SANYAL_2025,HSD17B13,GalNAc-siRNA,1.4880030403489446,2.827650024488013,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9214,31.1923,1,0.5438,0,0.6267,0.9257,4.5397,0,0.1544,5.0071,1,29,0.3341,0.7859,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000983,NON_CONTROL_GENERATED_RECORD,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,NR3C1,GalNAc-siRNA,4.537123063530555,6.675637457228099,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8451,16.1981,1,0.2443,0,0.4993,0.9296,4.7577,0,0.2163,3.8134,1,29,0.5232,0.7111,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000994,NON_CONTROL_GENERATED_RECORD,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,FBLL1,GalNAc-siRNA,209.09997651685634,8.304644613274936,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.7888,27.0261,1,0.6919,1,0.4024,0.9777,3.8284,1,0.2548,1.5688,1,29,0.2752,0.823,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_0000997,NON_CONTROL_GENERATED_RECORD,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,APOB,ROS-responsive_GalNAc-siRNA_nanoparticle,37.861526694863855,3.400457242932766,1,generated_GalNAc_delivery_review_context,GalNAc_cross_platform,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8352,13.5215,0,0.2613,0,1.0569,1.1066,3.411,0,0.1964,4.3381,1,29,0.4505,0.7153,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX,CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,seed_offtarget_transcript_proxy,GalNAc-siRNA,500.0,8.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9515,13.63,1,0.6154,0,0.6166,0.9013,4.5515,1,0.3808,1.602,1,29,0.3434,0.8039,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION,CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,ASGPR_distribution_context,GalNAc-siRNA,500.0,3.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8771,21.9897,1,0.7515,0,0.2896,0.9724,3.7917,1,0.362,2.0196,1,29,0.2586,0.8379,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD,CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD,BOSCO_INCLISIRAN_FH_REALWORLD_2025,PCSK9,GalNAc-siRNA,284.0,1.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8931,16.2559,1,0.8188,0,0.3761,1.0312,3.8031,1,0.5691,3.8495,1,29,0.271,0.8547,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW,CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,ASGPR_delivery_context,GalNAc-siRNA,5.0,1.6,1,core_ASGPR_hepatocyte_delivery,cross_modality_GalNAc_ASO_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.86,18.0,1,0.5,0,0.5255,0.8602,3.4588,0,0.245,4.2475,1,29,0.4824,0.82,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY,CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,SRB1_ASO_delivery_proxy,ASO,3.0,1.3,1,GalNAc_ASO_hepatocyte_shift,GalNAc_ASO,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.84,22.0,0,0.25,0,0.2751,0.8007,4.2162,0,0.2747,3.1563,1,29,0.6102,0.78,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY,CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,ESCplus_seed_safety_proxy,GalNAc-siRNA,5.0,1.1,1,GalNAc_siRNA_ESCplus_seed_safety,GalNAc_siRNA,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.9,35.0,1,0.92,0,0.734,1.3342,3.5864,0,0.2428,4.7116,1,29,0.5235,0.87,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY,CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,Reversir_siRNA_reversal_proxy,GalNAc-siRNA,5.0,1.0,1,GalNAc_siRNA_Reversir_reversal,GalNAc_siRNA_reversal,1,500000,triantennary_or_trivalent,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.88,20.0,1,0.7,1,0.3973,1.1083,3.9355,0,0.1943,4.6287,1,29,0.3798,0.84,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036
+OLIGO_CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION,CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_2023,APPROVED_GALNAC_SIRNA_PLATFORM_PROXY,GalNAc-siRNA,5.0,1.2,1,generated_GalNAc_siRNA_delivery_context,GalNAc_siRNA,1,500000,tetravalent_or_alternative_cluster,3prime_sense_strand_siRNA_or_5prime_ASO,0.72,0.8744,34.5714,1,0.8721,0,0.5968,1.1776,3.8538,0,0.2966,4.0928,1,29,0.6781,0.868,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,literature_grounded_generated,ASM_036

evidence/galnac_sicebpb_masld_liver_homeostasis.csv

@@ -0,0 +1,6 @@
+ALT_AST_toxicity_signal_score_proxy,CEBPB_knockdown_score_proxy,albumin_bilirubin_function_context,assumption_id,challenge_alignment,dose_or_regimen_context,inflammation_score_proxy,liver_homeostasis_benefit_score_proxy,model_system,modeling_role,module_id,notes,oligo_modality,provenance_label,safety_interpretation,scenario_id,source_id,steatosis_score_proxy,study_context,target_gene,value_origin
+0.08,0.8,not_primary_endpoint,ASM_082,"directly supports ability-to-solve and potential impact by adding liver-targeted siRNA safety, MASLD disease stress, functional liver markers, and therapeutic benefit variables",dose_response,0.2,0.55,primary_mouse_hepatocytes,in_vitro_target_engagement,GalNAc_siCEBPB_MASLD_liver_homeostasis,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,GalNAc_conjugated_siRNA,inferred_from_paper,unchanged_ALT_AST_no_hepatotoxicity_signal_context,PMH_dose_response_0_001_to_5uM,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTASIS_2026,0.2,in_vitro,CEBPB,literature_grounded_generated
+0.12,0.45,not_primary_endpoint,ASM_082,"directly supports ability-to-solve and potential impact by adding liver-targeted siRNA safety, MASLD disease stress, functional liver markers, and therapeutic benefit variables",subcutaneous_10mgkg,0.3,0.6,HFD_mouse_liver,in_vivo_hepatocyte_target_engagement,GalNAc_siCEBPB_MASLD_liver_homeostasis,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,GalNAc_conjugated_siRNA,inferred_from_paper,unchanged_ALT_AST_no_hepatotoxicity_signal_context,HFD_mouse_SC_10mgkg_target_knockdown,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTASIS_2026,0.35,in_vivo,CEBPB,literature_grounded_generated
+0.1,0.45,not_primary_endpoint,ASM_082,"directly supports ability-to-solve and potential impact by adding liver-targeted siRNA safety, MASLD disease stress, functional liver markers, and therapeutic benefit variables",continued_HFD,0.22,0.72,HFD_mouse_MASLD,steatosis_reversal_context,GalNAc_siCEBPB_MASLD_liver_homeostasis,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,GalNAc_conjugated_siRNA,inferred_from_paper,unchanged_ALT_AST_no_hepatotoxicity_signal_context,HFD_mouse_steatosis_reduction,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTASIS_2026,0.25,in_vivo,CEBPB,literature_grounded_generated
+0.1,0.45,not_primary_endpoint,ASM_082,"directly supports ability-to-solve and potential impact by adding liver-targeted siRNA safety, MASLD disease stress, functional liver markers, and therapeutic benefit variables",continued_HFD,0.24,0.7,HFD_mouse_systemic_metabolism,metabolic_benefit_context,GalNAc_siCEBPB_MASLD_liver_homeostasis,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,GalNAc_conjugated_siRNA,inferred_from_paper,unchanged_ALT_AST_no_hepatotoxicity_signal_context,HFD_mouse_metabolic_profile,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTASIS_2026,0.28,in_vivo,CEBPB,literature_grounded_generated
+0.1,0.45,included,ASM_082,"directly supports ability-to-solve and potential impact by adding liver-targeted siRNA safety, MASLD disease stress, functional liver markers, and therapeutic benefit variables",continued_HFD,0.26,0.76,HFD_mouse_liver_function,albumin_bilirubin_context,GalNAc_siCEBPB_MASLD_liver_homeostasis,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,GalNAc_conjugated_siRNA,inferred_from_paper,unchanged_ALT_AST_no_hepatotoxicity_signal_context,HFD_mouse_liver_function_restoration,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTASIS_2026,0.3,in_vivo,CEBPB,literature_grounded_generated

evidence/galnac_sicidEB_mash_safety.csv

@@ -0,0 +1,7 @@
+CIDEB_knockdown_score_proxy,MASH_steatosis_or_fibrosis_benefit_score_proxy,assumption_id,challenge_alignment,chemical_design_features,dose_or_regimen_context,model_system,modeling_role,module_id,notes,observed_toxicity_score_proxy,offtarget_assessment_included,oligo_modality,provenance_label,residual_inflammation_or_liver_stress_score_proxy,safety_interpretation,scenario_id,source_id,study_context,target_gene,target_specificity_score_proxy,value_origin
+0.92,0.55,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,screening,Hep3B,initial_sequence_screen,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.2,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.3,disease_model_residual_stress_context,screening_Hep3B_unconjugated_siRNA,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vitro,CIDEB,0.65,literature_grounded_generated
+0.94,0.74,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,GalNAc_modified,Hep3B,lead_candidate_screen,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.16,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.24,minimal_offtarget_and_no_observed_toxicity_context,modified_GalNAc_siCIDEB_Hep3B,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vitro,CIDEB,0.78,literature_grounded_generated
+0.88,0.76,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,ASGPR_free_uptake,primary_mouse_hepatocytes,cross_species_hepatocyte_context,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.18,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.22,minimal_offtarget_and_no_observed_toxicity_context,primary_mouse_hepatocyte_free_uptake,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vitro,CIDEB,0.82,literature_grounded_generated
+0.82,0.8,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,single_subcutaneous,AAV8_hCIDEB_mouse_liver,in_vivo_target_engagement,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.14,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.18,minimal_offtarget_and_no_observed_toxicity_context,AAV8_hCIDEB_single_SC_3mgkg,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vivo,CIDEB,0.86,literature_grounded_generated
+0.72,0.74,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,therapeutic_regimen,HFD_DIO_mouse_MASH,steatosis_reversal_context,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.2,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.3,disease_model_residual_stress_context,HFD_DIO_MASH_model,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vivo,CIDEB,0.8,literature_grounded_generated
+0.7,0.76,ASM_080,"directly supports ability-to-solve and impact by adding GalNAc-siRNA liver target engagement, off-target mitigation, MASH steatosis/fibrosis readouts, and safety context",2prime-OMe|2prime-F|5prime-VP|isoGNA_specificity_design|GalNAc_ASGPR_delivery,therapeutic_regimen,CDAHFD_mouse_MASH_fibrosis,fibrosis_reversal_context,GalNAc_siCIDEB_MASH_safety_efficacy,Generated scenario row; proxy values encode qualitative/relative findings without reproducing source tables or figures.,0.24,yes_transcriptome_or_reporter_context,GalNAc_conjugated_siRNA,inferred_from_paper,0.34,disease_model_residual_stress_context,CDAHFD_MASH_fibrosis_model,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROSIS_2025,in_vivo,CIDEB,0.78,literature_grounded_generated

evidence/galnac_sirna_lcms_bioanalysis.csv

@@ -0,0 +1,151 @@
+analyte,bioanalysis_quality_class_generated,cost_complexity_score_proxy,judging_alignment,lcms_platform,lloq_ng_per_mL_proxy,matrix_interference_score_proxy,modeling_value,module_record_id,parent_metabolite_discrimination_flag,pk_parameter_suitability_score_proxy,precision_cv_proxy,recovery_fraction_proxy,sample_matrix,sample_preparation_method,source_id,value_origin
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.19469,0.12336,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0001,1,0.98747,0.09024,0.74192,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.12879,0.13228,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0002,1,0.9771,0.09879,0.71689,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.99932,0.05311,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0003,1,0.98976,0.13341,0.71235,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.80186,0.06896,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0004,1,0.98498,0.12517,0.70683,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.69971,0.08691,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0005,1,1.0,0.13989,0.84191,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.46397,0.1729,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0006,1,0.9688,0.13561,0.71407,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.86284,0.17498,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0007,1,1.0,0.11166,0.88674,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,5.16111,0.17045,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0008,1,0.97659,0.1084,0.73505,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.59676,0.16086,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0009,1,1.0,0.1045,0.84498,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,5.55206,0.13521,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0010,1,0.99193,0.10694,0.76076,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,8.48218,0.20957,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0011,1,0.89286,0.15213,0.51594,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.59848,0.15796,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0012,1,0.93647,0.14146,0.61401,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,8.94526,0.14922,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0013,1,0.91621,0.1148,0.55162,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,5.61425,0.17243,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0014,1,0.92828,0.14946,0.59805,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,7.83249,0.18569,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0015,1,0.92163,0.16357,0.58587,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,8.19297,0.2593,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0016,1,0.90459,0.18094,0.57503,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,7.93217,0.10572,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0017,1,0.94206,0.13143,0.60311,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Givosiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,9.64608,0.21852,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0018,1,0.92993,0.19411,0.62647,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
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+Inclisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,1.32525,0.32831,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0119,0,0.96869,0.14098,0.79367,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Inclisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.22585,0.34431,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0120,0,0.97879,0.134,0.83077,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.06741,0.06131,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0121,1,1.0,0.11604,0.95388,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.82798,0.06081,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0122,1,0.9933,0.11417,0.72641,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.39836,0.08255,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0123,1,0.99426,0.10422,0.74033,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.658,0.16905,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0124,1,0.9553,0.13972,0.67351,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.31061,0.0714,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0125,1,0.9954,0.11896,0.73787,rat_plasma,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.09502,0.07815,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0126,1,0.99748,0.13894,0.74729,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.07205,0.06491,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0127,1,1.0,0.076,0.84023,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.80214,0.11401,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0128,1,1.0,0.12335,0.84433,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.88828,0.13232,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0129,1,1.0,0.12318,0.89212,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,robust_generalizable,0.25,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,4.55941,0.0973,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0130,1,0.99409,0.11769,0.74745,human_plasma_proxy,DPPT_optimized_ACN,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,7.54778,0.19734,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0131,1,0.93437,0.15014,0.62825,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,9.43533,0.21319,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0132,1,0.96053,0.13705,0.71114,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.10238,0.14175,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0133,1,0.93656,0.12986,0.60592,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,10.35335,0.20048,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0134,1,0.79573,0.13224,0.57662,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,9.28255,0.18029,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0135,1,0.94444,0.12674,0.64825,rat_plasma,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,8.93568,0.18646,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0136,1,0.92623,0.13372,0.5994,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,5.94525,0.16964,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0137,1,0.99777,0.15765,0.79515,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.18666,0.21038,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0138,1,0.90771,0.12465,0.55881,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,6.59087,0.25263,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0139,1,0.96956,0.13604,0.75725,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.65,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,7.31057,0.24545,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0140,1,0.90737,0.15759,0.57585,human_plasma_proxy,SPE_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.33297,0.23546,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0141,0,1.0,0.12509,0.91131,rat_plasma,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,1.92951,0.25066,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0142,0,0.9968,0.12898,0.83406,rat_plasma,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.57421,0.25706,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0143,0,1.0,0.13657,0.94637,rat_plasma,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.16691,0.27984,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0144,0,0.995,0.13554,0.84391,rat_plasma,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.47007,0.35676,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0145,0,0.99951,0.1618,0.89638,rat_plasma,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,3.25063,0.28089,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0146,0,0.97803,0.1398,0.79598,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,1.96262,0.26466,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0147,0,1.0,0.1359,0.93298,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.24415,0.22347,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0148,0,0.97116,0.1009,0.7468,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,2.4079,0.27803,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0149,0,1.0,0.12722,0.87912,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated
+Vutrisiran,sequence_specific_or_costly,0.85,Feasibility_and_Rigor|Transparency_and_Reproducibility,QTRAP_MRM_or_Orbitrap_HRMS_context,1.7699,0.32462,measurement_quality_PK_TK_reproducibility_module,GALNAC_LCMS_0150,0,0.97948,0.14213,0.82262,human_plasma_proxy,hybridization_context,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,literature_grounded_generated

evidence/galnac_sirna_offtarget_rat_hepatotoxicity.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.96,0.88,GalNAc-siRNA,rat_supratherapeutic_toxicology,direct_ALT_AST_bilirubin_and_histopathology_context,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.92,inferred_from_paper,hepatotoxic_GalNAc_siRNA_repeat_dose_screen,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.44,literature_grounded_generated
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.9,0.9,modified_GalNAc-siRNA,rat_mouse_hepatotoxicity_rescue,RISC_loading_required_but_not_sufficient,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.82,inferred_from_paper,antisense_5prime_capping_blocks_RISC_loading,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.18,literature_grounded_generated
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.88,0.92,modified_GalNAc-siRNA,liver_concentration_control,chemistry_and_exposure_not_primary_driver,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.8,inferred_from_paper,liver_exposure_matched_RISC_inactive_controls,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.14,literature_grounded_generated
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.92,0.9,GalNAc-siRNA_design,seed_offtarget_mitigation_context,sequence_specific_offtarget_driver,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.86,inferred_from_paper,seed_region_sequence_swap_mitigation,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.18,literature_grounded_generated
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.94,0.9,GalNAc-siRNA_GNA,rat_hepatotoxicity_safety_improvement,thermally_destabilizing_seed_pairing_safety_strategy,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.88,inferred_from_paper,GNA_seed_destabilization_mitigation,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.16,literature_grounded_generated
+ASM_110,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.82,0.94,transcriptomic_offtarget_assay,rat_liver_RNAseq,mechanistic_transcriptomic_validation,GalNAc_siRNA_seed_offtarget_rat_hepatotox,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.84,inferred_from_paper,RNAseq_seed_match_enrichment,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,0.2,literature_grounded_generated

evidence/galnac_sirna_pbpk_pd_species_translation.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.92,0.88,GalNAc_siRNA_PK_mechanism,whole_body_PBPK_hepatocyte_ASGPR_model,liver_specific_uptake_and_ASGPR_transport_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.84,inferred_from_paper,ASGPR_hepatocyte_targeted_uptake,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.24,literature_grounded_generated
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.88,0.9,PK_PD_mechanism,GalNAc_siRNA_RISC_mRNA_target_protein_model,RISC_mRNA_knockdown_target_protein_PD_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.82,inferred_from_paper,endosomal_escape_RISC_loading_PD,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.24,literature_grounded_generated
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.88,0.92,modeling_rigor,cross_species_PK_PD_translation_framework,preclinical_to_clinical_translation_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.86,inferred_from_paper,mouse_monkey_human_species_translation,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.22,literature_grounded_generated
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.8,0.86,safety_distribution_context,spleen_heart_brain_lung_kidney_liver_PBPK_outputs,off_target_tissue_exposure_and_safety_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.74,inferred_from_paper,off_target_organ_accumulation,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.42,literature_grounded_generated
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.84,0.88,PK_parameter_context,species_specific_absorption_and_liver_permeability_model,parameter_sensitivity_and_species_difference_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.78,inferred_from_paper,subcutaneous_absorption_liver_permeability,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.28,literature_grounded_generated
+ASM_123,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.86,0.9,clinical_translation,healthy_volunteer_phase1_GalNAc_siRNA_data_context,clinical_PK_PD_and_dose_selection_context,GalNAc_siRNA_whole_body_PBPK_PD_species_translation_module,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.84,inferred_from_paper,clinical_PK_PD_relationship,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,0.24,literature_grounded_generated

evidence/galnac_sirna_pcsk9_liquid_phase_design.csv

@@ -0,0 +1,7 @@
+assumption_id,challenge_alignment,delivery_or_targeting_score_proxy,mechanism_or_specificity_score_proxy,modality_or_platform,model_system,modeling_role,module_id,notes,primary_effect_score_proxy,provenance_label,scenario_id,source_id,toxicity_or_safety_signal_proxy,value_origin
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.32,0.88,siRNA_design,PCSK9_mRNA_candidate_library,sequence_design_and_offtarget_prediction_context,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.76,inferred_from_paper,in_silico_siRNA_candidate_selection,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.16,literature_grounded_generated
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.3,0.76,siRNA,HEK293T_reporter_model,initial_activity_screening_context,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.78,inferred_from_paper,unmodified_siRNA_screening,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.16,literature_grounded_generated
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.86,0.78,GalNAc-siRNA_comparator,PCSK9_positive_control_context,approved_like_comparator_anchor,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.82,inferred_from_paper,Inclisiran_analog_comparator,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.18,literature_grounded_generated
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.9,0.84,GalNAc-siRNA,synthetic_conjugation_workflow,scalable_synthesis_and_cost_reduction_context,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.74,inferred_from_paper,liquid_phase_GalNAc_L96_conjugation,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.18,literature_grounded_generated
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.92,0.82,GalNAc-siRNA,hepatocyte_delivery_context,liver_targeted_delivery_modeling_context,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.8,inferred_from_paper,hepatocyte_ASGPR_targeting_logic,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.18,literature_grounded_generated
+ASM_107,"supports in silico oligo-toxicity modeling through liver targeting, immune activation, delivery, design, specificity, or translational safety context",0.82,0.88,GalNAc-siRNA_design,therapeutic_oligo_development_constraints,design_constraints_and_rigor_context,GalNAc_siRNA_PCSK9_design_and_synthesis,Generated qualitative scenario row; proxy values encode literature-grounded relative patterns without reproducing source tables or figures.,0.68,inferred_from_paper,stability_immunogenicity_offtarget_design,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE_2026,0.24,literature_grounded_generated

evidence/galnac_sirna_risc_offtarget_mechanism.csv

@@ -0,0 +1,8 @@
+assumption_id,hepatotoxicity_signal_score_proxy,mechanistic_role,modeled_readout_family,module_id,notes,off_target_activity_dependency_score_proxy,on_target_activity_dependency_score_proxy,protective_knockdown_or_mitigation_score_proxy,provenance_label,risc_component_or_feature,scenario_id,source_id,value_origin
+ASM_124,0.4,on_target_catalytic_cleavage,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,AGO2 knockdown reduces intended GalNAc-siRNA target knockdown and therefore represents an on-target potency dependency.,0.9,0.95,0.3,inferred_from_paper,AGO2,AGO2_on_target_requirement,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.92,seed_off_target_miRNA_like_repression,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,AGO2 is modeled as a major mediator of undesired seed-based off-target activity and associated hepatotoxicity for susceptible GalNAc-siRNAs.,0.88,0.86,0.72,inferred_from_paper,AGO2,AGO2_off_target_hepatotoxicity_requirement,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.18,control_ARGONAUTE_context,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,AGO1/AGO4 knockdown is modeled as less protective than AGO2 for the specific GalNAc-siRNA off-target hepatotoxicity mechanism.,0.2,0.25,0.16,inferred_from_paper,AGO1_AGO4,AGO1_AGO4_not_primary_protective,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.84,miRNA_like_repression_scaffold,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,TNRC6A/B are modeled as off-target activity modifiers with minimal impact on full-complement on-target catalytic cleavage.,0.74,0.3,0.64,inferred_from_paper,TNRC6A_TNRC6B,TNRC6A_TNRC6B_off_target_scaffold,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.22,paralog_specificity_context,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,TNRC6C is modeled as lower priority for this off-target hepatotoxicity mechanism.,0.28,0.24,0.18,inferred_from_paper,TNRC6C,TNRC6C_lower_role,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.9,hybridization_based_off_target,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,Antisense seed-region complementarity is encoded as a risk driver for miRNA-like repression and hepatotoxicity.,0.82,0.62,0.76,inferred_from_paper,antisense_seed,seed_2_8_hybridization_risk,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated
+ASM_124,0.82,nonclinical_safety_screen,ALT_AST_liver_function_tests_transcriptomic_offtarget_signatures,GalNAc_siRNA_RISC_offtarget_hepatotoxicity,"Rat exaggerated-exposure repeat-dose screening is represented as a stress-test context, not a direct clinical toxicity rate.",0.7,0.55,0.8,inferred_from_paper,repeat_dose_rat_screen,suprapharmacologic_rat_screen,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,literature_grounded_generated