diff --git "a/data_dictionary_full.csv" "b/data_dictionary_full.csv"
new file mode 100644--- /dev/null
+++ "b/data_dictionary_full.csv"
@@ -0,0 +1,2602 @@
+table,column,type,non_null_count,unique_value_count,sample_values,table_description
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,oligo_id,string,4,4,OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STAB | OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB | OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,source_id,categorical,4,1,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,control_id,string,4,4,CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE | CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLA | CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,target_gene,string,4,3,AGO1 | AGO1_NFKB_context | AGO1_paracrine_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,modality,string,4,3,LNP-delivered LNA gapmer ASO | LNA gapmer ASO mechanism context | LNA gapmer ASO cell-interaction context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,sequence_length,integer,4,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,gc_content,float,4,3,0.5 | 0.4375 | 0.5625,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,dose,integer,4,2,1.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatotox_score,float,4,4,1.6 | 3.8 | 2.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatotoxicity_label,categorical,4,1,low,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,value_origin,categorical,4,1,literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,assumption_id,categorical,4,1,ASM_039,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,ago1_lnp_aso_context,string,4,4,LNP_AGO1_ASO_low_hepatic_injury | endothelial_AGO1_NFKB_p65_inflammation | AAV9_PCSK9_HFHCD_liver_vascular_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,preprint_caution_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,LNP_formulation_flag,integer,4,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,LNA_gapmer_ASO_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,target_gene_context,categorical,4,1,AGO1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,primary_cell_context,categorical,4,1,endothelial_cell_or_liver_sinusoidal_end,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,disease_model_context,categorical,4,1,AAV9_PCSK9_high_fat_high_cholesterol_ath,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,AGO1_mRNA_knockdown_fraction_proxy,float,4,4,0.75 | 0.58 | 0.62,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,AGO1_ASO_dose_mg_kg_proxy,integer,4,2,1.0 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,NFkB_p65_coactivation_score_proxy,float,4,4,0.051 | 0.046 | 0.156,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,ICAM1_reduction_score_proxy,float,4,4,0.817 | 0.689 | 0.703,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,VCAM1_reduction_score_proxy,float,4,4,0.772 | 0.704 | 0.611,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,CCL2_reduction_score_proxy,float,4,4,0.766 | 0.684 | 0.596,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,THBS1_reduction_score_proxy,float,4,4,0.81 | 0.736 | 0.579,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,monocyte_adhesion_reduction_score_proxy,float,4,4,0.711 | 0.668 | 0.652,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,EC_hepatocyte_paracrine_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,lipid_profile_improvement_score_proxy,float,4,4,0.82 | 0.25 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,LDL_VLDL_reduction_score_proxy,float,4,4,0.861 | 0.22 | 0.743,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,HDL_ratio_improvement_score_proxy,float,4,4,0.707 | 0.452 | 0.568,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_steatosis_reduction_score_proxy,float,4,4,0.597 | 0.23 | 0.666,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_macrophage_infiltration_reduction_score_proxy,float,4,4,0.671 | 0.604 | 0.597,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_fibrosis_reduction_score_proxy,float,4,4,0.498 | 0.406 | 0.531,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,atherosclerotic_plaque_reduction_score_proxy,float,4,4,0.775 | 0.541 | 0.742,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,ALT_fold_change_proxy,float,4,3,0.95 | 1.0 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,AST_fold_change_proxy,float,4,3,0.96 | 1.0 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,no_evident_hepatotoxicity_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,ALT_AST_safety_monitoring_score_proxy,integer,4,1,1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,direct_oligotox_relevance_modifier,float,4,1,0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,delivery_translatability_score_proxy,float,4,2,0.9 | 0.64,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,phase2_controls_relevance_score,float,4,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,phase2_translatability_relevance_score,float,4,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,ago1_lnp_aso_context_confidence_score,float,4,1,0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ago1_lnp_aso_endothelial_liver_vascular_context.csv,supporting_hepatotoxicity_class_proxy,string,4,4,negative_control_low_ALT_AST | mechanism_context | disease_model_safety_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,agt_knockdown_fraction_proxy,float,80,79,0.81166 | 0.95 | 0.79169,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,alt_fold_uln_proxy,float,80,80,1.27272 | 1.55479 | 3.57951,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,antisense_5prime_vinylphosphonate,integer,80,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,ast_fold_uln_proxy,float,80,78,1.18919 | 1.41634 | 3.13879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,candidate_class,categorical,80,4,potent_safe_candidate | screened_candidate | toxic_offtarget_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,duration_of_effect_days_proxy,float,80,80,171.76849 | 163.52268 | 64.96638,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,galnac_conjugated,integer,80,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,hepg2_ic50_pM_proxy,float,80,80,2.16816 | 15.56973 | 13.13051,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,histopathology_kidney_damage_score_proxy,float,80,71,0.06869 | 0.24681 | 0.38247,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,histopathology_liver_damage_score_proxy,float,80,72,0.08334 | 0.34752 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,huh7_ic50_pM_proxy,float,80,80,2.27624 | 15.80328 | 3.23476,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,judging_alignment,categorical,80,1,Ability_to_Solve_Challenge|Feasibility_a,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,modality,categorical,80,1,chemically_modified_GalNAc_AGT_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,modeling_value,categorical,80,1,direct_predictor_and_safety_label_module,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,modification_pattern_family,categorical,80,4,AL_alternating_2F_2MOE | DV29PG5_like | DV_reduced_2F_rearranged,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,module_record_id,identifier,80,80,AGT_SIRNA_TOX_0001 | AGT_SIRNA_TOX_0002 | AGT_SIRNA_TOX_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,oligo_id,string,80,80,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,predicted_offtarget_gene_count_proxy,integer,80,55,31 | 63 | 106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,ps_linkage_count_proxy,integer,80,12,7 | 4 | 6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,rnaseq_dose_dependent_downregulated_gene_count_proxy,integer,80,57,16 | 86 | 254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,safety_class_generated,categorical,80,4,favorable | screening_required | toxicity_signal,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,source_id,categorical,80,1,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,target_gene,categorical,80,1,AGT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,two_prime_F_fraction_proxy,float,80,80,0.26653 | 0.30695 | 0.19715,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,two_prime_MOE_fraction_proxy,float,80,80,0.34198 | 0.41723 | 0.34811,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,urea_fold_baseline_proxy,float,80,80,1.16478 | 1.48813 | 1.30616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+agt_galnac_sirna_development_toxicology.csv,value_origin,categorical,80,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_context_id,string,1120,1120,ANGPTL3_CTRL_OLIGO_NEG_VEHICLE_MOCK | ANGPTL3_CTRL_OLIGO_NEG_LOW_RISK | ANGPTL3_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_platform_context,categorical,1120,4,not_ANGPTL3_targeted | GalNAc_siRNA_ARO_ANG3_like | GalNAc_ASO_vupanorsen_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_liver_safety_state,categorical,1120,5,baseline_non_ANGPTL3 | ANGPTL3_siRNA_moderate_inhibition_liver_ | ANGPTL3_ASO_high_inhibition_hepatic_fat_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_target_inhibition_pct_proxy,float,1120,32,0.0 | 78.0 | 94.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_hepatic_fat_change_pct_proxy,float,1120,42,0.0 | -28.0 | 72.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_alt_ast_gt3x_uln_probability_proxy,float,1120,29,0.0 | 0.01 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_transaminase_signal_fold_ULN_proxy,float,1120,42,1.0 | 1.05 | 3.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_liver_safety_stress_modifier,float,1120,42,0.0 | 0.10986 | 1.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,angptl3_liver_safety_protective_modifier,float,1120,26,0.0 | 0.9 | 0.33212,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,context_note,categorical,1120,2,platform-specific ANGPTL3 liver-safety p | platform-specific ANGPTL3 liver-safety c,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+angptl3_liver_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,PK_PD_utility,string,5,5,supports_PK_PD_biodistribution | supports_extrahepatic_tissue_distributio | supports_systemic_PK,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,active_payload,categorical,5,1,free_unconjugated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,analytical_platform,categorical,5,1,hybridization_LC-MS/MS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,capture_strategy,categorical,5,1,biotinylated_complementary_probe_hybridi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,challenge_alignment,categorical,5,1,"supports feasibility, rigor, transparenc",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,conjugate_or_payload_context,string,5,4,Fab-ASO | antibody-ASO_or_Fab-ASO | intact_AOC_plus_ASO_linker,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,free_ASO_recovery_proxy,float,5,5,0.82 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,matrix,string,5,4,liver | gastrocnemius | plasma_or_serum,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,method_specificity_score_proxy,float,5,5,0.91 | 0.88 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,module_id,categorical,5,1,AOC_free_ASO_payload_bioanalysis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,notes,categorical,5,1,Generated measurement-quality row; no pr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,parent_or_linker_interference_risk,string,5,5,low | low_to_moderate | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,sample_preparation_logic,string,5,4,removed_to_avoid_artifactual_conversion | method_dependent | removed_or_minimized,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,scenario_id,string,5,5,liver_free_ASO_payload | gastrocnemius_free_ASO_payload | plasma_serum_free_ASO_payload,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,source_id,categorical,5,1,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aoc_free_aso_payload_bioanalysis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,ago2_loading_score_proxy,float,160,160,0.54062 | 0.63207 | 0.64345,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,alt_fold_uln_proxy,float,160,159,1.12338 | 0.99955 | 0.95159,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,apoc3_mrna_reduction_fraction_proxy,float,160,160,0.46835 | 0.54975 | 0.6303,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,candidate_scaffold_class,categorical,160,5,standard_clinical_surrogate | reduced_2F_long_acting_lead | high_2F_potent_shorter,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,delivery_ligand,categorical,160,1,triantennary_GalNAc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,dosing_interval_burden_score_proxy,float,160,156,0.17618 | 0.29272 | 0.2916,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,duration_index_proxy,float,160,156,0.82382 | 0.70728 | 0.7084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,judging_alignment,categorical,160,1,Ability_to_Solve_Challenge|Potential_Imp,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,modeling_value,categorical,160,1,direct_GalNAc_siRNA_SAR_duration_safety_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,module_record_id,string,160,160,APOC3_SIRNA_0001 | APOC3_SIRNA_0002 | APOC3_SIRNA_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,ps_terminal_linkage_count_proxy,integer,160,9,4 | 3 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,route,categorical,160,1,subcutaneous_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,safety_class_generated,categorical,160,3,favorable_long_acting | intermediate | selectivity_or_tolerability_concern,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,selectivity_offtarget_count_proxy,integer,160,66,21 | 15 | 36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,source_id,categorical,160,1,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,species_or_system,categorical,160,4,human_hepatocyte_cell | huAPOC3_mouse | CD1_tolerability_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,target,categorical,160,1,APOC3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,tolerability_score_proxy,float,160,155,0.87779 | 0.85338 | 0.79009,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,triglyceride_reduction_fraction_proxy,float,160,159,0.54846 | 0.53884 | 0.6399,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,two_prime_F_fraction_proxy,float,160,160,0.39493 | 0.41112 | 0.40711,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,two_prime_OMe_MOE_fraction_proxy,float,160,158,0.50881 | 0.52948 | 0.52038,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+apoc3_galnac_sirna_sar_safety.csv,value_origin,categorical,160,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,assumption_id,categorical,7,1,ASM_125,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,chemistry_or_delivery_feature,string,7,7,phosphorothioate_backbone | 2prime_F_RNA | 2prime_OMe_RNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,clinical_maturity_score_proxy,float,7,7,0.88 | 0.8 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,dataset_context,string,7,7,broad_ASO_distribution_context | approved_siRNA_chemistry_context | common_approved_siRNA_modification,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,delivery_specificity_score_proxy,float,7,7,0.8 | 0.74 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,functional_interpretation,string,7,7,nuclease_resistance_and_protein_binding | stability_potency_modification | stability_and_immunostimulation_mitigati,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,generic_safety_complexity_score_proxy,float,7,6,0.7 | 0.58 | 0.54,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,module_id,categorical,7,1,approved_oligonucleotide_chemistry_deliv,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,notes,categorical,7,1,Reference row used to standardize chemis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,primary_modality_context,string,7,5,ASO_gapmer_SSO | siRNA_aptamer | splice_switching_oligo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,source_id,categorical,7,1,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+approved_oligo_chemistry_landscape.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,oligo_id,identifier,43,43,OLIGO_0000019 | OLIGO_0000043 | OLIGO_0000133,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,source_id,string,43,28,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024 | QU_CPG_ODN_APAP_TLR9_IRG1_2025 | JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,control_id,categorical,43,12,NON_CONTROL_GENERATED_RECORD | CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RIS | CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,target_gene,string,43,29,CYP2E1 | ANGPTL8 | PNPLA3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,modality,categorical,43,7,scpBNA2_gapmer_ASO | LNA_cEt_PS_gapmer_ASO | LNA gapmer ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,sequence_length,integer,43,11,23 | 21 | 22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,gc_content,float,43,32,0.5217391304347826 | 0.3333333333333333 | 0.4545454545454545,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,seed_region,string,11,11,CGCGUUG | CUAUCUU | ACGUAAA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,hepatotox_score,float,43,43,5.17518697853974 | 3.788891218794384 | 8.08105735589514,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,hepatotoxicity_label,categorical,43,3,moderate | low | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,value_origin,categorical,43,2,literature_grounded_generated | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,assumption_id,categorical,43,8,ASM_002 | ASM_041 | ASM_043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,aso_gapmer_screen_state,categorical,43,2,generated_background | encoded,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,lna_gapmer_screen_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,rnase_h1_gapmer_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,fully_phosphorothioated_gapmer_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,gapmer_length_nt_proxy,integer,43,3,14 | 16 | 15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,acute_mouse_screen_days_proxy,integer,43,1,3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,acute_mouse_screen_dose_mg_kg_proxy,integer,43,2,100.0 | 30.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,repeat_dose_mouse_days_proxy,integer,43,1,15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,repeat_dose_rank_concordance_score_proxy,float,43,39,0.735 | 0.722 | 0.753,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,plasma_ALT_fold_vs_control_proxy,float,43,43,7.452 | 4.395 | 6.944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,plasma_AST_fold_vs_control_proxy,float,43,43,4.238 | 2.292 | 4.182,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,ALT_AST_average_fold_proxy,float,43,43,5.845 | 3.344 | 5.563,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,liver_weight_fold_vs_control_proxy,float,43,40,1.335 | 1.154 | 1.293,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,predicted_offtarget_hit_count_proxy,integer,43,43,286 | 75 | 463,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,potent_offtarget_effect_count_proxy,integer,43,24,37 | 9 | 25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,transcriptome_selectivity_score_proxy,float,43,42,0.617 | 0.776 | 0.648,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,mouse_human_OTE_concordance_score_proxy,float,43,37,0.779 | 0.91 | 0.743,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,in_silico_OTE_prediction_required_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,transcriptome_wide_selectivity_screen_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,ALT_AST_liver_weight_streamlined_endpoint_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,positive_negative_control_applicable_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,hepatotoxicity_screen_rank_label,categorical,43,6,high_OTE_hepatotoxicity_like | intermediate_screen_signal | high_OTE_high_ALT_AST_positive_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,screening_hepatotoxicity_class_proxy,categorical,43,4,high | moderate | low,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,screening_recommendation,categorical,43,5,deselect_or_redesign | redesign_or_follow_with_RNAseq_selectivi | progress_with_standard_safety_followup,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,phase2_experimental_design_relevance_score,float,43,2,0.67 | 0.94,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,phase2_translatability_relevance_score,float,43,2,0.62 | 0.91,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,phase2_controls_relevance_score,float,43,2,0.7 | 0.95,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_gapmer_hepatotoxicity_screening.csv,aso_gapmer_screen_context_confidence_score,float,43,2,0.55 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,PS_protein_binding_stress_score_proxy,float,6,6,0.7 | 0.15 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,assumption_id,categorical,6,1,ASM_081,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,challenge_alignment,categorical,6,1,supports feasibility and rigor by encodi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,chemical_modification_context,string,6,6,none | clinical_like_reference | 2prime-OMe_gap_position_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,late_onset_neurotoxicity_score_proxy,float,6,6,0.82 | 0.12 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,liver_oligotox_relevance,categorical,6,1,cross_organ_ASO_toxicity_and_chemistry_m,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,model_system,string,6,5,mouse_i_c_v_or_rat_i_t | CNS_reference | in_vitro_and_in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,modeling_role,string,6,6,toxic_parent_reference | non_toxic_reference | toxicity_reduction_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,module_id,categorical,6,1,ASO_late_onset_neurotoxicity_chemical_mo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,notes,categorical,6,1,Generated cross-organ toxicity scenario ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,oligo_modality,categorical,6,1,gapmer_PS_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,p53_regulated_transcript_stress_score_proxy,float,6,6,0.78 | 0.18 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,paraspeckle_p54nrb_mislocalization_score_proxy,float,6,6,0.75 | 0.16 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,scenario_id,string,6,6,parent_gapmer_ASO_late_toxic | non_toxic_reference_ASO5 | 2prime_OMe_position_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,source_id,categorical,6,1,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIF,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,target_knockdown_preservation_score_proxy,float,6,6,0.35 | 0.6 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_late_onset_neurotox_chemical_modifications.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_context_id,string,1120,1120,ASONAFLD_CTRL_OLIGO_NEG_VEHICLE_MOCK | ASONAFLD_CTRL_OLIGO_NEG_LOW_RISK | ASONAFLD_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_nafld_state,categorical,1120,7,baseline_non_ASO_metabolic_context | GalNAc_ASO_hepatocyte_targeted_metabolic | high_affinity_gapmer_hepatotoxic_sequenc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_target_class,categorical,1120,6,not_applicable | lipid_partitioning_or_DNL | DNL_or_lipid_target_with_injury_risk,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_RNase_H1_gapmer_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_GalNAc_hepatocyte_targeting_multiplier_proxy,integer,1120,2,1.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_predicted_steatosis_change_proxy,float,1120,119,0.0 | -0.42 | -0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_insulin_sensitivity_improvement_proxy,float,1120,119,0.0 | 0.26 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_DNL_pathway_suppression_proxy,float,1120,119,0.0 | -0.36 | -0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_benefit_score,float,1120,117,0.0 | 0.78 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_hepatic_injury_challenge_score,float,1120,119,0.0 | 0.08 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_ALT_AST_monitoring_fold_proxy,float,1120,119,1.0 | 1.05 | 3.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_GGT_monitoring_fold_proxy,float,1120,119,1.0 | 1.02 | 2.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_sequence_motif_toxicity_context,categorical,1120,5,not_applicable | none_detected | TCC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_sequence_motif_risk_score,float,1120,107,0.0 | 0.05 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_type_I_interferon_response_proxy,float,1120,104,0.0 | 0.04 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_kidney_injury_monitoring_proxy,float,1120,100,0.0 | 0.05 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_tissue_distribution_context,categorical,1120,3,not_applicable | hepatocyte_targeted_GalNAc | broad_ASO_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_hepatic_injury_modifier,float,1120,118,0.0 | 1.1072 | 0.52,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_benefit_modifier,float,1120,117,0.0 | 0.78 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,aso_metabolic_safety_label,categorical,1120,4,ASO_context_intermediate | ASO_metabolic_benefit_low_injury | ASO_safety_challenge,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,context_note,categorical,1120,2,ASO metabolic/NAFLD benefit and safety-c | ASO metabolic/NAFLD context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_metabolic_nafld_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,HepG2_apoptosis_or_cell_stress_score_proxy,float,36,34,0.009 | 0.016 | 0.019,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,aso_profile_id,categorical,36,6,vehicle_PBS | 569713 | LNA32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,challenge_alignment,categorical,36,1,directly supports feasibility/rigor by m,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,chemistry_design,categorical,36,3,vehicle | LNA_3-10-3_PS_gapmer | LNA_3-8-3_PS_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,intended_on_target_transcript,categorical,36,5,none | none_control_ASO | mMYD88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,modeling_role,categorical,36,5,baseline_control | non_toxic_ASO_control | non_toxic_targeting_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,module_id,categorical,36,1,ASO_time_resolved_multiomics_safety,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,mouse_ALT_IU_per_L_proxy,integer,36,4,31 | 29 | 159,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,notes,categorical,36,1,Generated time-course row; proxy values ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,pathway_perturbation_score_proxy,float,36,36,0.012 | 0.021 | 0.026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,protein_level_offtarget_burden_score_proxy,float,36,36,0.009 | 0.016 | 0.019,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,proteomics_de_risking_relevance,categorical,36,2,moderate_or_low | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,provenance_label,categorical,36,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,rna_level_offtarget_burden_score_proxy,float,36,36,0.016 | 0.027 | 0.032,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,rna_protein_offtarget_discordance_score_proxy,float,36,34,0.006 | 0.011 | 0.013,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,safety_assessment_layer,categorical,36,1,RNAseq|global_proteomics|qPCR|western_bl,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,source_id,categorical,36,1,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,timepoint_hours,integer,36,6,8 | 24 | 32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,toxicity_class,categorical,36,4,non_toxic_reference | non_toxic | medium_liver_toxic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+aso_multiomics_time_resolved_safety.csv,value_origin,categorical,36,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+assays.csv,assay_id,string,5600,5600,ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T72 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T168,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,oligo_id,string,5600,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,source_id,string,5600,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,control_id,string,5600,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,model_system,categorical,5600,3,in_vitro_liver_model | clinical_proxy | animal_cell_model,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,cell_model,string,5600,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,human_in_vitro_or_clinical_proxy,integer,5600,2,1 | 0,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,species,categorical,5600,3,human | mouse | rat,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,organoid_or_MPS,integer,5600,2,0 | 1,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,assay_type,categorical,5600,1,hepatotoxicity_readout_panel,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,time_hours,integer,5600,5,24 | 72 | 168,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,replicate_count,integer,5600,1,3,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,record_origin,categorical,5600,1,dbbun_generated,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assays.csv,value_origin,categorical,5600,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
+assumptions.csv,assumption_id,identifier,76,76,ASM_001 | ASM_002 | ASM_003,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,assumption_category,string,58,58,synthetic_data_scope | predictor_framework | PS_content,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,assumption_text,string,62,62,"Generated records are not measured exper | Sequence-derived, chemistry-derived, bio | Higher phosphorothioate content increase",Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,impact,string,54,46,Prevents overclaiming and preserves tran | Defines the multivariable risk score and | Affects chemical modification table and ,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,confidence,categorical,52,8,high | medium_high | medium,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,record_origin,categorical,76,1,method_assumption,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,source_basis,string,5,5,RAPIROSIRAN_SANYAL_2025 | DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025 | HAUPTMANN_SIRNA_BULGES_GALNAC_2022,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,impact_on_generation,string,8,8,"Adds AGT/RAAS clinical-platform variable | Adds bulge length, position, region, gui | Adds FBLL1 expression, malignant-hepatoc",Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,assumption_label,string,1,1,OGT_sEV_LSEC_capillarization_MASLD_conte,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,description,string,14,14,"Lipotoxic hepatocyte-derived sEVs can be | HBx-induced MALAT1, m6A modification, IG | CD133-positive cancer stem cell enrichme",Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,applies_to,string,1,1,ogt_sev_lsec_masld_context.csv,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,risk_if_wrong,string,1,1,Could overstate relevance of extracellul,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,mitigation,string,1,1,"Label as supporting context only, keep v",Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,assumption_type,string,4,4,supporting_HBV_HCC_ASO_MALAT1_context | supporting_MASLD_HCC_CD133_siRNA_combina | supporting_GalNAc_RBC_EV_hepatocyte_deli,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,source_id,string,8,8,DU_MALAT1_HBV_HCC_ASO_2025 | PAN_CD133_MASLD_HCC_SIRNA_2025 | HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,assumption_name,string,8,8,ALD_ALDH2_Nrf2_oxidative_stress_context | calcium_phosphate_hybrid_nanoparticle_si | PMEVL_sEV_small_RNA_loading_hepatic_siRN,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,source_ids,string,4,4,MA_FORMONONETIN_ALDH2_ALD_2025 | VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024 | WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,expected_use,string,4,4,supporting_liver_context_not_direct_olig | supporting_delivery_platform_safety_cont | supporting_sEV_RNA_delivery_and_hepatic_,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,evidence_source_id,identifier,23,23,BI_IFNA_DISULFIDPTOSIS_HCC_2026 | JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_201 | BOSCO_INCLISIRAN_FH_REALWORLD_2025,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,rationale,string,5,5,The source paper reports that a 3-day ac | The source preprint reports LNP-delivere | The GYS1 Pompe preprint reports a system,Explicit list of biological and modeling assumptions used in dataset generation.
+assumptions.csv,generated_variables,string,4,4,"HSC activation, collagen translation/exp | Reversible silencing, induction, shRNA/s | RISC loading, 5-prime capping rescue, se",Explicit list of biological and modeling assumptions used in dataset generation.
+bepirovirsen_immunomodulation_alt.csv,ALT_increase_association_score_proxy,float,6,6,0.05 | 0.18 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,HBsAg_decline_response_score_proxy,float,6,6,0.05 | 0.21 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,apoptosis_liver_specific_protein_score_proxy,float,6,6,0.08 | 0.34 | 0.39,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,challenge_alignment,categorical,6,1,"directly strengthens Ability-to-Solve, P",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,clinical_biomarker_layers,categorical,6,1,serum_proteomics|whole_blood_transcripto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,direct_antiviral_HBV_RNA_targeting,categorical,6,1,yes_all_HBV_RNAs,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,disease_context,categorical,6,1,chronic_HBV_on_stable_nucleoside_analog_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,immune_cell_transcript_activation_score_proxy,float,6,6,0.1 | 0.46 | 0.64,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,immune_effector_activation_score_proxy,float,6,6,0.12 | 0.72 | 0.66,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,module_id,categorical,6,1,bepirovirsen_ASO_immunomodulation_ALT_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,notes,categorical,6,1,Generated clinical-biomarker scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,oligo_modality,categorical,6,1,unconjugated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,scenario_id,string,6,6,baseline_NA_background | week3_effector_apoptotic_serum_proteins | week5_immune_cell_activation_transcripts,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,source_id,categorical,6,1,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,therapeutic_ALT_interpretation,categorical,6,2,low_or_baseline_ALT_context | possible_infected_hepatocyte_killing_sig,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,time_context,string,6,6,pre_dose | week_3 | week_5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+bepirovirsen_immunomodulation_alt.csv,week_on_bepirovirsen_proxy,integer,6,4,0 | 3 | 5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,assumption_id,categorical,7,1,ASM_103,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,challenge_alignment,categorical,7,1,"supporting module for oligo modality, de",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,delivery_or_targeting_score_proxy,float,7,6,0.58 | 0.74 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,mechanism_or_specificity_score_proxy,float,7,7,0.62 | 0.78 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,modality_or_platform,string,7,4,EMNV | hybrid_EMNV_liposome | EMNV_surface_engineering,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,model_system,string,7,6,cell_derived_nanovesicles | extruded_Hyb_nanoparticles | HepG2_and_mouse_cell_lines,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,modeling_role,string,7,7,biological_nanoparticle_baseline | RNA_loading_and_fusion_context | intracellular_RNA_delivery_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,module_id,categorical,7,1,biologics_Hyb_EMNV_liposome_RNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,notes,categorical,7,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,primary_effect_score_proxy,float,7,6,0.64 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,scenario_id,string,7,7,EMNV_baseline_biological_nanovesicle | Hyb_extrusion_fusion_RNA_loading | FAM_RNA_intracellular_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,source_id,categorical,7,1,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_D,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,toxicity_or_safety_signal_proxy,float,7,4,0.14 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biologics_hyb_targeted_rna_delivery.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+biophysical_properties.csv,biophysical_id,string,1120,1120,BIO_CTRL_OLIGO_NEG_VEHICLE_MOCK | BIO_CTRL_OLIGO_NEG_LOW_RISK | BIO_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,nucleotide_composition_A,integer,1120,18,0 | 8 | 6,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,nucleotide_composition_C,integer,1120,16,0 | 3 | 4,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,nucleotide_composition_G,integer,1120,17,0 | 4 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,nucleotide_composition_U,integer,1120,16,0 | 10 | 7,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,GC_content,float,1120,177,0.0 | 0.19 | 0.48,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,seed_region_GC,float,1120,14,0.0 | 0.14 | 0.43,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,longest_continuous_complementarity,integer,1120,19,0 | 2 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,mismatch_count_proxy,integer,1120,17,0 | 8 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,predicted_offtarget_hybridization_burden,float,1120,986,0.0 | 0.6 | 2.0,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,predicted_Tm_celsius,float,1120,1015,0.0 | 48.0 | 61.5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,predicted_delta_G_kcal_mol,float,1120,1026,0.0 | -9.5 | -17.5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,binding_affinity_proxy,float,1120,1015,0.0 | 0.55 | 1.35,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+biophysical_properties.csv,record_origin,categorical,1120,1,dbbun_generated,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
+brothers_aso_pna_toxicity_mitigation.csv,alt_fold_uln_proxy,float,120,120,2.86136 | 2.8546 | 2.86853,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,aso_type,categorical,120,2,GalNAc_LNA_gapmer_ASO | ASO_PNA_BRO_duplex,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,body_weight_fraction_baseline_proxy,float,120,120,0.93419 | 0.95447 | 0.95169,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,design_class,categorical,120,6,parent_mPCS1_ssASO | BRO_PNA12_high_Tm | BRO_PNA11_high_Tm,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,dose_nmol_per_kg,integer,120,5,25 | 50 | 100,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,duplex_tm_celsius_proxy,float,120,120,-0.5003 | 3.12249 | -0.42215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,ed50_nmol_per_kg_context_proxy,float,120,6,35.3 | 78.0 | 61.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,judging_alignment,categorical,120,1,Ability_to_Solve_Challenge|Feasibility_a,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,modeling_value,categorical,120,1,direct_ASO_offtarget_hepatotoxicity_miti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,module_record_id,identifier,120,120,BRO_ASO_PNA_0001 | BRO_ASO_PNA_0002 | BRO_ASO_PNA_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,pcsk9_knockdown_fraction_proxy,float,120,120,0.60552 | 0.54928 | 0.55674,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,pna_brother_strand_length_nt,integer,120,6,0 | 12 | 11,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,protein_binding_score_proxy,float,120,120,0.60402 | 0.66532 | 0.60084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,rna_offtarget_hybridization_score_proxy,float,120,120,0.77649 | 0.76773 | 0.72702,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,safety_class_generated,categorical,120,3,toxic_active_parent | low_activity_or_context | mitigated_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,source_id,categorical,120,1,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,therapeutic_margin_score_proxy,float,120,120,0.20799 | 0.1891 | 0.19076,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,toehold_domain_present,integer,120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,toehold_mismatch_discrimination_score_proxy,float,120,120,0.22351 | 0.23227 | 0.27298,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+brothers_aso_pna_toxicity_mitigation.csv,value_origin,categorical,120,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_state,categorical,1120,6,not_modeled | CD133_positive_CSC_MASLD_HCC_MKI_resista | VNP_siCD133_plus_MKI_MASLD_HCC_tumor_sup,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_context_type,categorical,1120,2,not_applicable | MASLD_HCC_CD133_CSC_siRNA_combination_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_csc_enrichment_score_proxy,float,1120,11,0.0 | 0.6903 | 0.15281,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_lineage_expansion_score_proxy,float,1120,11,0.0 | 0.70237 | 0.26398,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_self_renewal_score_proxy,float,1120,11,0.0 | 0.52925 | 0.31909,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_tumor_initiating_capacity_proxy,float,1120,11,0.0 | 0.57136 | 0.3212,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_mki_resistance_score_proxy,float,1120,11,0.0 | 0.64538 | 0.295,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_myh9_interaction_score_proxy,float,1120,11,0.0 | 0.61556 | 0.40532,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_wnt_bcat_activation_score_proxy,float,1120,11,0.0 | 0.65246 | 0.26837,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_active_bcat_repression_after_sicd133_proxy,float,1120,11,0.0 | 0.14181 | 0.92585,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_vnp_sicd133_delivery_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_2prime_ome_pyrimidine_modification_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_sorafenib_combo_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_lenvatinib_combo_context_flag,integer,1120,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_tumor_weight_reduction_score_proxy,float,1120,10,0.0 | 0.01178 | 0.97091,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_ki67_reduction_score_proxy,float,1120,11,0.0 | 0.0748 | 0.7024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_tunel_apoptosis_increase_score_proxy,float,1120,9,0.0 | 0.18804 | 0.9184,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_therapeutic_rescue_score_proxy,float,1120,11,0.0 | 0.08229 | 0.88652,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_hepatocarcinogenesis_context_modifier,float,1120,10,0.0 | 0.52621 | 0.6982,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_direct_oligotox_relevance_modifier,float,1120,11,0.0 | 0.12161 | 0.15195,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_context_confidence_score,float,1120,11,0.0 | 0.78501 | 0.90674,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,context_note,categorical,1120,3,Supporting CD133/MASLD-HCC siRNA context | Supporting MASLD-HCC CD133 cancer-stem-c | No CD133/MASLD-HCC siRNA context modeled,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd133_masld_hcc_sirna_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,assumption_id,categorical,6,1,ASM_105,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,delivery_or_targeting_score_proxy,float,6,5,0.88 | 0.92 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,mechanism_or_specificity_score_proxy,float,6,6,0.76 | 0.78 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,modality_or_platform,categorical,6,2,GalNAc-siRNA | host_target_silencing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,model_system,string,6,6,Hep3B_and_primary_mouse_hepatocytes | C57BL6_mouse_liver | rodent_malaria_mouse_challenge,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,modeling_role,string,6,6,hepatocyte_target_sequence_screening | durable_hepatocyte_receptor_silencing | host_factor_infection_prevention_endpoin,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,module_id,categorical,6,1,CD81_GalNAc_siRNA_liver_stage_malaria_pr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,primary_effect_score_proxy,float,6,5,0.82 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,scenario_id,string,6,6,cross_species_siRNA_screen | in_vivo_liver_CD81_knockdown_durability | pyoelii_liver_stage_protection,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,source_id,categorical,6,1,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,toxicity_or_safety_signal_proxy,float,6,4,0.16 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cd81_galnac_sirna_malaria_protection.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+challenge_alignment_scorecard.csv,dataset_evidence,string,10,10,"oligos, chemistry, dose/exposure, assays | information_gap_map.csv maps each source | validation_summary.csv, control profiles",Mapping of dataset components to challenge judging factors.
+challenge_alignment_scorecard.csv,demonstration_file,string,10,10,model_readiness_report.csv; validation_s | information_gap_map.csv | validation_summary.csv; data_dictionary.,Mapping of dataset components to challenge judging factors.
+challenge_alignment_scorecard.csv,judging_criterion,categorical,10,4,Ability to Solve the Challenge | Potential Impact | Feasibility and Rigor,Mapping of dataset components to challenge judging factors.
+challenge_alignment_scorecard.csv,notes,string,10,10,Dataset is structured for in silico olig | Emphasizes gaps not well covered by sing | Reviewer-facing checks are generated wit,Mapping of dataset components to challenge judging factors.
+challenge_alignment_scorecard.csv,status,categorical,10,1,demonstrated,Mapping of dataset components to challenge judging factors.
+chemical_modifications.csv,modification_id,string,1120,1120,MOD_CTRL_OLIGO_NEG_VEHICLE_MOCK | MOD_CTRL_OLIGO_NEG_LOW_RISK | MOD_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,sugar_chemistry,string,1120,41,not_applicable | 2prime_OMe | mixed,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,backbone_class,categorical,1120,3,low_or_no_PS | partial_PS | high_PS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,phosphorothioate_fraction,float,1120,906,0.0 | 0.05 | 0.22,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,phosphorothioate_tertile,categorical,1120,3,low_PS | high_PS | medium_PS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,GalNAc_conjugated,integer,1120,2,0 | 1,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,modification_pattern,string,1120,94,not_applicable | 2prime_OMe|low_PS|GalNAc=0 | mixed|low_PS|GalNAc=1,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,modification_locations,string,1120,29,not_applicable | generated_terminal_and_internal_pattern_ | generated_terminal_and_internal_pattern_,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,purity,float,1120,901,1.0 | 0.985 | 0.975,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,purity_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,characterization_method,string,1120,60,not_applicable | HPLC+LC-MS | LC-MS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,characterization_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,record_origin,categorical,1120,1,dbbun_generated,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+chemical_modifications.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
+cholangiocyte_cholestasis_recovery_context.csv,oligo_id,identifier,21,21,OLIGO_0000018 | OLIGO_0000027 | OLIGO_0000216,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,control_id,categorical,21,5,NON_CONTROL_GENERATED_RECORD | CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_AL | CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,source_id,categorical,21,1,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,target_gene,string,21,17,CYP2E1 | APOC3 | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,modality,string,21,14,GalNAc-siRNA | gapmer | splice-switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,cell_model,unknown,0,0,,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,cholestasis_context_flag,integer,21,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,cholestasis_state,categorical,21,5,generated_cholestatic_cholangiocyte_cont | DDC_peak_cholestatic_liver_injury | R15_recovery_resolution_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,DDC_reversible_cholestasis_model_flag,integer,21,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,ALT_fold_proxy,float,21,21,8.4074 | 15.7998 | 13.9634,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,ALP_fold_proxy,float,21,21,2.4815 | 3.96 | 3.5927,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,bilirubin_fold_proxy,float,21,21,4.3333 | 7.6599 | 6.8335,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,cholesterol_fold_proxy,float,21,21,1.9259 | 2.85 | 2.6204,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,ductular_reaction_CK19_SOX9_score_proxy,float,21,21,0.5988 | 0.7427 | 0.7069,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,CX3CL1_expression_fold_proxy,float,21,20,3.5926 | 6.1799 | 5.5372,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,CX3CR1_macrophage_recruitment_score_proxy,float,21,21,0.4593 | 0.718 | 0.6537,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,PICSS_pathway_activation_score_proxy,float,21,21,0.5093 | 0.768 | 0.7037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,PICSS_upregulated_gene_count_proxy,integer,21,17,50 | 75 | 68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,NFYA_nuclear_activation_score_proxy,float,21,21,0.4407 | 0.681 | 0.6213,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,TGFB1_expression_score_proxy,float,21,21,0.4924 | 0.6245 | 0.5917,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,fibrosis_collagen_activation_score_proxy,float,21,21,0.4708 | 0.5435 | 0.5254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,recovery_resolution_score_proxy,float,21,21,0.6296 | 0.26 | 0.3518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,siRNA_NFYA_TGFB1_reduction_context_flag,integer,21,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,siRNA_NFYA_TGFB1_reduction_fraction_proxy,float,21,2,0.0 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,direct_oligotox_hepatotoxicity_relevance,categorical,21,1,supporting_not_direct,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,phase2_alignment,categorical,21,1,endpoint_diversity_cholestasis_fibrosis_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,value_origin,categorical,21,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cholangiocyte_cholestasis_recovery_context.csv,assumption_id,categorical,21,1,ASM_041,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+controls.csv,control_id,string,161,161,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,control_type,string,161,154,negative_control_vehicle_mock | negative_control_low_risk_oligo | clinical_low_hepatotoxicity_reference,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,control_role,string,109,109,baseline_no_active_oligo | low_sequence_chemistry_exposure_risk | GalNAc_siRNA_clinical_safety_reference,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,expected_behavior,string,84,68,"no oligo-driven hepatotoxicity signal | high viability, low ALT/AST proxy, low s | low-to-moderate synthetic hepatotoxicity","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,control_rationale,string,93,60,"Represents mock/vehicle exposure with do | Low PS content, low off-target burden, m | Inspired by a Phase I GalNAc-siRNA trial","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,source_basis,string,109,51,OligoTox alignment memo control logic | OligoTox predictor framework | RAPIROSIRAN_SANYAL_2025,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,provenance_label,categorical,98,2,literature_grounded_generated | inferred_from_paper,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,record_origin,categorical,161,1,dbbun_generated,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,license_for_generated_output,categorical,161,1,CC BY 4.0,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,expected_direction,string,56,55,low_hepatotoxicity_context | systemic_monitoring_not_primary_hepatoto | durable_PD_context,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,rationale,string,33,33,"Represents zilebesiran-like hepatocyte-t | Keeps hyperkalemia, hypotension, and eGF | Represents prolonged siRNA effect from h","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,source_id,categorical,35,9,MA_FORMONONETIN_ALDH2_ALD_2025 | VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024 | WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,description,string,52,52,Alcohol-related liver injury context wit | Formononetin-like rescue context with AL | AAV8 siRNA knockdown context in which lo,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,expected_response,string,17,17,high_hepatotoxicity | low_hepatotoxicity | screening_context,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+controls.csv,expected_outcome,string,4,4,high_cholestatic_liver_injury_signal | resolved_or_low_cholestatic_liver_injury | cholangiocyte_macrophage_interaction_con,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
+cpg_odn_apap_macrophage_immunomodulation.csv,acod1_irg1_expression_score_proxy,float,60,56,0.0 | 0.78419 | 0.85563,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,alt_fold_baseline_proxy,float,60,60,4.83313 | 2.72066 | 2.71467,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,apap_dose_mg_per_kg_context,integer,60,1,300,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,cpg_odn_dose_mg_per_kg_context,float,60,2,0.0 | 1.65,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,hepatocyte_viability_proxy,float,60,60,0.33992 | 0.82849 | 0.89456,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,inflammatory_cytokine_burden_proxy,float,60,60,0.80217 | 0.35343 | 0.35178,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,interpretation,categorical,60,3,APAP_liver_injury_reference | protective_macrophage_immunomodulation | loss_of_mechanism_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,itaconate_metabolite_score_proxy,float,60,60,0.04951 | 0.82117 | 0.91427,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,judging_alignment,categorical,60,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,macrophage_apoptosis_score_proxy,float,60,60,0.67357 | 0.12694 | 0.13935,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,modeling_value,categorical,60,1,immune_cell_liver_injury_context_and_mec,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,module_record_id,identifier,60,60,CPG_APAP_0001 | CPG_APAP_0002 | CPG_APAP_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,nfkb_activation_score_proxy,float,60,37,0.0 | 0.73879 | 0.66751,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,nrf2_antioxidant_response_score_proxy,float,60,60,0.28645 | 0.84815 | 0.82064,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,oligodeoxynucleotide_class,categorical,60,1,CpG_ODN_1826_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,ros_score_proxy,float,60,60,0.76397 | 0.24291 | 0.26175,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,scenario,categorical,60,5,APAP_only | CpG_ODN_pretreatment | CpG_ODN_treated_macrophage_reinfusion,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,source_id,categorical,60,1,QU_CPG_ODN_APAP_TLR9_IRG1_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,survival_improvement_score_proxy,float,60,60,0.32511 | 0.76079 | 0.72887,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,target_cell_context,categorical,60,4,AML12_hepatocyte_coculture | RAW2647_macrophage | Kupffer_cell,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,tlr9_activation_score_proxy,float,60,37,0.0 | 0.60034 | 0.84461,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cpg_odn_apap_macrophage_immunomodulation.csv,value_origin,categorical,60,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,assumption_id,categorical,6,1,ASM_122,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,delivery_or_targeting_score_proxy,float,6,6,0.12 | 0.16 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,mechanism_or_specificity_score_proxy,float,6,5,0.84 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,modality_or_platform,string,6,6,liver_injury_context | regulated_cell_death_mechanism | dose_response_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,model_system,string,6,6,ATP7B_knockout_mouse_Wilson_disease_mode | ATP7B_KO_liver_and_HepG2_cuproptosis_mod | copper_exposed_HepG2_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,modeling_role,string,6,6,copper_overload_ALT_AST_LDH_hepatocellul | FDX1_DLAT_DLST_LIAS_mitochondrial_cell_d | copper_dose_viability_and_cytotoxicity_r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,module_id,categorical,6,1,ATP7B_copper_cuproptosis_liver_injury_si,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.72 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,scenario_id,string,6,6,ATP7B_KO_copper_overload_liver_injury | cuproptosis_marker_activation | copper_exposure_LDH_viability_shift,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,source_id,categorical,6,1,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,toxicity_or_safety_signal_proxy,float,6,6,0.64 | 0.56 | 0.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+cuproptosis_wilson_liver_injury.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+data_dictionary.csv,allowed_values_or_range,categorical,82,11,0 or 1 | 0 to 1 | controlled generated categories,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,column_name,string,256,253,source_id | title | source_role,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,data_type,categorical,367,7,string_or_numeric | integer_flag | float,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,description,string,380,369,Unique source identifier. | Source paper or memo title. | How the source contributes to generation,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,field_name,string,124,122,preprint_caution_flag | ALT_AST_safety_monitoring_score_proxy | delivery_translatability_score_proxy,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,origin_rule,categorical,256,1,reported/extracted/inferred/generated/no,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,provenance,categorical,13,1,literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,provenance_expectation,categorical,35,2,source_metadata | literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,required,categorical,367,2,yes | no,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,table_name,string,380,79,sources.csv | controls.csv | oligos.csv,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,type,categorical,13,1,float_or_string,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+data_dictionary.csv,value_origin,categorical,76,1,literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
+dilimap_toxpredictor_dili_toxicogenomics.csv,assumption_id,categorical,6,1,ASM_111,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,delivery_or_targeting_score_proxy,float,6,4,0.32 | 0.36 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,mechanism_or_specificity_score_proxy,float,6,4,0.94 | 0.92 | 0.96,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,modality_or_platform,string,6,6,toxicogenomics | ML_toxicity_model | random_forest_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,model_system,string,6,6,sandwich_cultured_primary_human_hepatocy | multi_concentration_transcriptomics_PK_c | DILI_positive_negative_validation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,modeling_role,string,6,6,large_scale_human_hepatocyte_reference_r | dose_and_exposure_resolved_modeling_cont | validation_sensitivity_specificity_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,module_id,categorical,6,1,DILImap_ToxPredictor_DILI_toxicogenomics,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,primary_effect_score_proxy,float,6,6,0.72 | 0.74 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,scenario_id,string,6,6,PHH_RNAseq_300_compound_library | dose_resolved_DILI_safety_margin | blind_validation_high_specificity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,source_id,categorical,6,1,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,toxicity_or_safety_signal_proxy,float,6,5,0.2 | 0.22 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dilimap_toxpredictor_dili_toxicogenomics.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dose_exposure.csv,dose_exposure_id,string,1120,1120,DOSE_CTRL_OLIGO_NEG_VEHICLE_MOCK | DOSE_CTRL_OLIGO_NEG_LOW_RISK | DOSE_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,dose_nM,float,1120,899,0.0 | 10.0 | 180.0,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,dose_tier,categorical,1120,6,vehicle_or_mock | very_low | medium,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,exposure_duration_days,integer,1120,24,1.0 | 3.0 | 84.0,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,treatment_frequency,string,1120,54,single | monthly | weekly,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,relative_exposure_normalization,float,1120,888,0.0 | 0.06667 | 1.2,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,relative_exposure_basis,categorical,1120,1,multiples_of_150_nM_reference,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,dose_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dose_exposure.csv,record_origin,categorical,1120,1,dbbun_generated,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
+dual_rgd_sirna_nanocarrier_delivery.csv,assumption_id,categorical,6,1,ASM_101,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,challenge_alignment,categorical,6,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,delivery_or_targeting_score_proxy,float,6,6,0.7 | 0.62 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,immune_or_cell_state_score_proxy,float,6,4,0.45 | 0.4 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,modality_or_platform,string,6,5,noncationic_protein_carrier | dual_RGD_targeting | histidine_buffering,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,model_system,string,6,6,in_vitro_binding | serum_RNase_assay | integrin_positive_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,modeling_role,string,6,6,load_to_go_siRNA_binding | siRNA_protection_context | tumor_targeting_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,module_id,categorical,6,1,dual_RGD_non_cationic_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,primary_effect_score_proxy,float,6,6,0.88 | 0.82 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,scenario_id,string,6,6,dual_RGD_dsRBD_18His_binding | RNase_serum_stability | integrin_avb3_targeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,source_id,categorical,6,1,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,toxicity_or_safety_signal_proxy,float,6,6,0.16 | 0.14 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+dual_rgd_sirna_nanocarrier_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,epigenetic_context_id,string,1120,1120,EPI_CTRL_OLIGO_NEG_VEHICLE_MOCK | EPI_CTRL_OLIGO_NEG_LOW_RISK | EPI_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,epigenetic_liver_state,categorical,1120,6,baseline | SULT1B1_siRNA_rescue | MASLD_H3K27ac_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,h3k27ac_super_enhancer_activity_proxy,float,1120,1043,0.29499 | 0.38197 | 0.2496,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,cebp_beta_activity_proxy,float,1120,1047,0.49209 | 0.41983 | 0.49633,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,sult1b1_expression_proxy,float,1120,1042,0.15097 | 0.38913 | 0.26762,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,oleate_lipid_loading_model,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,jq1_like_SE_inhibition,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,sult1b1_siRNA_knockdown,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,cebp_beta_siRNA_knockdown,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,hepatocyte_lipid_accumulation_proxy,float,1120,1033,0.18698 | 0.34023 | 0.16991,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,epigenetic_liver_stress_modifier,float,1120,1002,0.11709 | 0.17455 | 0.10737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,epigenetic_rescue_score,float,1120,4,0.0 | 0.4 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,epigenetic_lipid_context_label,categorical,1120,3,low | high | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,super_enhancer_activity_label,categorical,1120,3,low | moderate | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,context_note,categorical,1120,1,supporting MASLD epigenetic/lipid-accumu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+epigenetic_liver_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,aptamer_length_nt_context,integer,55,1,40,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,auc_0_5400_proxy,float,55,55,12.30571 | 12.67163 | 15.87586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,biliary_excretion_fraction_context,float,5,1,0.083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,cmax_percent_injected_dose_per_g_proxy,float,55,55,7.32945 | 7.74009 | 7.89772,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,dominant_excretion_or_distribution_route,categorical,55,9,systemic_distribution | renal_excretion | hepatic_biliary_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,estimated_effective_dose_mGy_per_MBq_context,float,55,1,0.00189,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,hepatobiliary_or_renal_burden_flag,integer,55,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,judging_alignment,categorical,55,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,modeling_value,categorical,55,1,oligonucleotide_ADME_PK_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,module_record_id,string,55,55,ERBB2_APT_PK_0001 | ERBB2_APT_PK_0002 | ERBB2_APT_PK_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,oligonucleotide_type,categorical,55,1,ERBB2_specific_DNA_aptamer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,organ_or_tissue,categorical,55,11,heart | kidney | liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,radiolabeling_strategy,categorical,55,1,fluorine18_complementary_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,renal_excretion_fraction_context,float,10,1,0.778,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,route,categorical,55,1,intravenous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,source_id,categorical,55,1,PARK_ERBB2_APTAMER_PET_PK_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,target,categorical,55,1,ERBB2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,target_visualization_score_proxy,float,55,51,0.43803 | 0.46311 | 0.48553,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,terminal_half_life_seconds_proxy,float,55,55,1605.21774 | 1787.76691 | 1645.95571,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,tmax_seconds_proxy,float,55,55,222.74629 | 332.91156 | 278.52277,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+erbb2_aptamer_pet_pk.csv,value_origin,categorical,55,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,ALT_elevation_liability_proxy,float,25,25,0.14811 | 0.20586 | 0.45626,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,ESCplus_flag,integer,25,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,GNA_seed_flag,integer,25,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,assumption_id,categorical,25,1,ASM_062,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,challenge_gap_addressed,categorical,25,1,public_data_gap_for_GalNAc_siRNA_seed_of,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,chemistry_vs_global_tm_note,categorical,25,1,single_seed_GNA_or_2_5_RNA_modeled_as_sp,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,design_class,categorical,25,5,parent_ESC_GalNAc_siRNA | ESCplus_single_GNA_position6 | ESCplus_single_2_5_RNA_seed,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,dose_mg_per_kg_proxy,integer,25,5,1 | 3 | 10,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,judging_alignment,categorical,25,1,Ability_to_Solve|Potential_Impact|Feasib,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,modality,categorical,25,1,GalNAc_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,modeling_value,categorical,25,1,"directly supports seed-region chemistry,",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,module_record_id,string,25,25,supplemental_ESCPLUS_parent_ESC_GalNAc_s | supplemental_ESCPLUS_parent_ESC_GalNAc_s | supplemental_ESCPLUS_parent_ESC_GalNAc_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,on_target_activity_retention_proxy,float,25,23,1.0 | 0.97451 | 0.9318,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,predicted_offtarget_transcript_dysregulation_proxy,float,25,25,0.02201 | 0.20319 | 0.35283,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,seed_mediated_offtarget_binding_proxy,float,25,25,0.14563 | 0.23173 | 0.41861,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,seed_pairing_destabilization_score_proxy,float,25,25,0.85153 | 0.84323 | 0.82614,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,seed_region_modification,categorical,25,4,none | GNA_position6 | 2_5_RNA_seed,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,source_id,categorical,25,1,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIR,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,source_role,categorical,25,1,direct_GalNAc_siRNA_offtarget_hepatotoxi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,target_context,categorical,25,1,HBV_or_liver_expressed_target_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,therapeutic_window_proxy,float,25,25,3.04772 | 2.52553 | 1.46449,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+escplus_seed_pairing_safety_mechanism.csv,value_origin,categorical,25,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_delivery_id,string,1120,1120,EXTRA_CTRL_OLIGO_NEG_VEHICLE_MOCK | EXTRA_CTRL_OLIGO_NEG_LOW_RISK | EXTRA_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_delivery_state,categorical,1120,5,baseline_liver_focused | dystrophic_muscle_delivery | extrahepatic_delivery_with_liver_exposur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_conjugate_type,categorical,1120,2,none | cholesterol_conjugate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_administration_route,categorical,1120,5,not_extrahepatic_context | intraperitoneal | intravenous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,systemic_dose_mg_per_kg_proxy,integer,1120,3,0.0 | 10.0 | 20.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_dosing_schedule,categorical,1120,5,not_applicable | weekly_x4 | single,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,treatment_duration_weeks_proxy,integer,1120,3,0.0 | 4.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,target_tissue_class,categorical,1120,4,not_extrahepatic_context | mdx_dystrophic_skeletal_muscle | mixed_muscle_and_liver_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,dystrophic_muscle_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,skeletal_muscle_knockdown_pct_proxy,float,1120,22,0.0 | 36.0 | 24.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,tibialis_anterior_knockdown_pct_proxy,float,1120,22,0.0 | 39.7 | 18.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,diaphragm_knockdown_pct_proxy,float,1120,22,0.0 | 32.7 | 15.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,heart_knockdown_pct_proxy,float,1120,21,0.0 | 12.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,liver_knockdown_pct_proxy,float,1120,17,0.0 | 41.3 | 44.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,liver_marker_signal_fold_proxy,float,1120,22,1.0 | 1.02 | 1.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,kidney_urea_signal_fold_proxy,float,1120,21,1.0 | 1.05 | 1.28493,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,extrahepatic_delivery_confidence_score,float,1120,22,0.0 | 0.65875 | 0.52045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,liver_exposure_context_label,categorical,1120,2,minimal_or_not_modeled | measurable_liver_knockdown_without_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,context_note,categorical,1120,2,extrahepatic delivery/distribution conte | extrahepatic delivery context; not a dir,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+extrahepatic_delivery.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,EMT_reversal_score_proxy,float,6,6,0.06 | 0.08 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,H3K27me3_residual_score_proxy,float,6,6,0.9 | 0.82 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,apoptosis_or_cell_cycle_effect_score_proxy,float,6,6,0.08 | 0.12 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,challenge_alignment,categorical,6,1,supports ability-to-solve by adding spli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,exon14_skipping_score_proxy,float,6,6,0.03 | 0.06 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,full_length_EZH2_residual_score_proxy,float,6,6,0.92 | 0.86 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,liver_relevance,categorical,6,1,HCC_liver_therapeutic_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,mechanism,categorical,6,1,steric_blocking_exonic_splicing_enhancer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,model_system,string,6,4,MHCC97H_HCC | HCCLM3_HCC | mouse_peripheral_tissue_liver_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,modeling_role,string,6,6,baseline_HCC_control | sequence_specificity_control | lead_splice_switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,module_id,categorical,6,1,EZH2_exon_skipping_HCC_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,oligo_modality,categorical,6,1,splice_switching_MOE_PS_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,scenario_id,string,6,6,buffer_control_HCC_cells | mismatch_MOE_PS_ASO | lead_ASO35_58_25nM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,source_id,categorical,6,1,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,target_or_splicing_element,string,6,3,none | mismatch_control | EZH2_exon14_ESE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,tumor_growth_inhibition_score_proxy,float,6,6,0.1 | 0.14 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ezh2_exon_skipping_hcc_aso.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_hcc_state,categorical,1120,5,not_modeled | generic_FBLL1_HCC_context | FBLL1_high_malignant_hepatocyte_spatial_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_expression_context,categorical,1120,3,not_applicable | high_FBLL1 | FBLL1_knockdown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_malignant_hepatocyte_enrichment_score,float,1120,150,0.0 | 0.76989 | 0.89287,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_spatial_tumor_niche_score,float,1120,149,0.0 | 0.85403 | 0.90992,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_high_expression_survival_risk_proxy,float,1120,151,0.0 | 0.66233 | 0.91136,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_ribosome_biogenesis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_siRNA_knockdown_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_knockdown_proliferation_suppression_proxy,float,1120,126,0.0 | 0.1273 | 0.18117,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_knockdown_colony_suppression_proxy,float,1120,121,0.0 | 0.3092 | 0.05518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_overexpression_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_overexpression_tumorigenesis_proxy,float,1120,150,0.0 | 0.2359 | 0.00794,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_hepatocyte_dedifferentiation_score_proxy,float,1120,154,0.0 | 0.78178 | 0.56324,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_ALB_downregulation_proxy,float,1120,159,0.0 | 1.07112 | 1.39801,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_MYC_upregulation_proxy,float,1120,145,0.0 | 0.73209 | 0.20102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_EGFR_ligand_upregulation_score_proxy,float,1120,141,0.0 | 0.9713 | 0.96127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_EGFR_MAPK_activation_score_proxy,float,1120,156,0.0 | 0.67626 | 0.26712,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_HCC_malignant_context_modifier,float,1120,159,0.0 | 0.81614 | 0.77149,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_direct_oligotox_relevance_modifier,float,1120,5,0.0 | 0.1 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,fbll1_context_confidence_score,float,1120,159,0.0 | 0.68903 | 0.79043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,context_note,categorical,1120,3,No FBLL1/HCC context modeled for this ro | Supporting FBLL1/HCC spatial multi-omics | Supporting FBLL1/HCC context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fbll1_hcc_spatial_oncogenic_context.csv,value_origin,categorical,1120,4,not_reported | literature_grounded_generated | inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,GalNAc_or_hepatocyte_targeting_context,string,4,2,yes | yes_contextual_GalNAc_hepatocyte_targeti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,active_ingredient_or_landscape_item,string,4,4,fitusiran | donidalorsen | plozasiran,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,administration_route,categorical,4,1,subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,assumption_id,categorical,4,1,ASM_129,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,clinical_maturity_score_proxy,float,4,3,0.92 | 0.9 | 0.95,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,direct_oligotox_row_level_endpoint,categorical,4,1,no_landscape_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,indication_context,string,4,4,hemophilia_A_or_B_bleeding_prevention | hereditary_angioedema_attack_prevention | familial_chylomicronemia_syndrome_trigly,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,modality_context,string,4,3,siRNA | ASO_or_ligand_conjugated_oligo_context | GalNAc_platform,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,module_id,categorical,4,1,FDA_TIDES_2025_oligonucleotide_landscape,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,notes,categorical,4,1,Landscape row for current approved oligo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,provenance_label,categorical,4,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,source_id,categorical,4,1,ALSHAER_FDA_TIDES_HARVEST_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,therapeutic_target,string,4,4,antithrombin_III_mRNA | prekallikrein_mRNA | APOC3_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,trade_name_or_summary_label,string,4,4,Qfitlia | Dawnzera | Redemplo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fda_tides_2025_oligo_landscape.csv,value_origin,categorical,4,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+figure_label_dictionary.csv,display_label,string,12,12,Gapmer ASO | GalNAc-LNA ASO | EV liver context,Definitions of figure labels and panel descriptions.
+figure_label_dictionary.csv,figure,categorical,12,1,fig07,Definitions of figure labels and panel descriptions.
+figure_label_dictionary.csv,full_modality_name,string,12,12,gapmer | GalNAc-LNA-ASO | extracellular_vesicle_liver_context,Definitions of figure labels and panel descriptions.
+figure_label_dictionary.csv,median_risk_score,float,12,10,10.0 | 9.78578 | 9.76845,Definitions of figure labels and panel descriptions.
+figure_label_dictionary.csv,n_readouts,integer,12,10,1695 | 1155 | 150,Definitions of figure labels and panel descriptions.
+formononetin_aldh2_nrf2_ald_context.csv,oligo_id,string,3,3,OLIGO_CTRL_POS_ALD_ACETALDEHYDE_ROS_MITO | OLIGO_CTRL_NEG_FORMONONETIN_ALDH2_NRF2_H | OLIGO_CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,source_id,categorical,3,1,MA_FORMONONETIN_ALDH2_ALD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,control_id,string,3,3,CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDR | CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOP | CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,target_gene,string,3,3,ALDH2 | NFE2L2 | ALDH2_NFE2L2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,oligo_modality,categorical,3,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,aldh2_nrf2_ald_state,string,3,2,formononetin_ALDH2_Nrf2_hepatoprotection | ALDH2_or_Nrf2_siRNA_loss_of_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,alcohol_related_liver_disease_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,formononetin_like_treatment_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,AAV8_siRNA_ALDH2_or_Nrf2_knockdown_context_flag,integer,3,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ALDH2_activity_fold_proxy,float,3,2,1.28 | 0.34,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,acetaldehyde_burden_fold_proxy,float,3,2,0.58 | 2.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,hepatic_ROS_fold_proxy,float,3,2,0.52 | 2.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,lipid_peroxidation_TBARS_fold_proxy,float,3,2,0.478 | 2.208,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,four_HNE_signal_fold_proxy,float,3,2,0.458 | 2.112,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,mitochondrial_quantity_TOM20_fold_proxy,float,3,2,1.18 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,NAD_NADH_ratio_fold_proxy,float,3,2,1.133 | 0.403,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ATP_level_fold_proxy,float,3,2,1.097 | 0.391,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,complex_I_activity_fold_proxy,float,3,2,1.062 | 0.378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,Nrf2_activity_fold_proxy,float,3,2,1.35 | 0.31,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,HO1_expression_fold_proxy,float,3,2,1.418 | 0.326,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,GSH_GSSG_ratio_fold_proxy,float,3,2,1.22 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,GPX4_level_fold_proxy,float,3,2,1.159 | 0.361,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ERK1_2_AP1_activation_context_score,float,3,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ALT_AST_liver_injury_fold_proxy,float,3,2,0.72 | 1.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ALD_oxidative_stress_modifier,float,3,2,-0.804 | 2.471,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,ALD_context_confidence_score,float,3,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,assumption_id,categorical,3,1,ASM_029,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+formononetin_aldh2_nrf2_ald_context.csv,record_origin,categorical,3,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,ALT_signal_proxy,float,18,18,0.0 | 0.06004 | 0.13932,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,AST_signal_proxy,float,18,18,0.0 | 0.0834 | 0.03869,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,FXR_protective_axis_score_proxy,float,18,18,0.81342 | 0.83357 | 0.79115,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,G0s2_expression_proxy,float,18,18,0.76041 | 0.80551 | 0.77367,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,JNK_activation_proxy,float,18,18,0.0 | 0.01652 | 0.05831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,assumption_id,categorical,18,1,ASM_064,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,bile_acid_disorder_proxy,float,18,18,0.03955 | 0.09328 | 0.13015,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,carnitine_disorder_proxy,float,18,18,0.06449 | 0.15989 | 0.11304,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,challenge_gap_addressed,categorical,18,1,mechanistic_liver_toxicity_pathway_covar,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,injury_model,categorical,18,1,triptolide_induced_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,intervention_arm,categorical,18,6,vehicle_control | triptolide_DILI | triptolide_plus_JNK_inhibitor_SP600125,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,judging_alignment,categorical,18,1,Ability_to_Solve|Potential_Impact,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,long_chain_fatty_acid_disorder_proxy,float,18,18,0.11929 | 0.1 | 0.07044,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,metabolic_hepatotoxicity_score_proxy,float,18,18,0.03 | 0.0802 | 0.0923,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,modality,categorical,18,1,DILI_pathway_siRNA_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,modeling_value,categorical,18,1,supports liver-injury pathway features f,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,module_record_id,string,18,18,supplemental_DILI_vehicle_control_6h | supplemental_DILI_vehicle_control_24h | supplemental_DILI_vehicle_control_48h,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,siRNA_knockdown_context_flag,integer,18,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,source_id,categorical,18,1,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICIT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,source_role,categorical,18,1,supporting_liver_injury_metabolic_pathwa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,timepoint_hour,integer,18,3,6 | 24 | 48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+fxr_jnk_g0s2_dili_context.csv,value_origin,categorical,18,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,oligo_id,string,196,196,CTRL_OLIGO_POS_HIGH_OFFTARGET | CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS | CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,control_id,categorical,196,19,CTRL_POS_HIGH_OFFTARGET | CTRL_POS_TRANSCRIPTOMIC_STRESS | CTRL_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,source_id,string,196,44,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023 | PNPLA3_ROMEO_VALENTI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,target_gene,string,196,58,generic_offtarget | generic_stress_pathway | ANGPTL3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,modality,categorical,196,15,siRNA | GalNAc-siRNA | gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,dose,float,196,185,420.0 | 650.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,hepatotox_score,float,196,182,9.45832434447446 | 9.42258069012478 | 3.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_liver_delivery_context_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_liver_delivery_state,categorical,196,7,generated_GalNAc_siRNA_delivery_context | generated_GalNAc_delivery_review_context | generated_GalNAc_ASO_delivery_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_delivery_modality_class,categorical,196,5,GalNAc_siRNA | GalNAc_cross_platform | GalNAc_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,asgpr_hepatocyte_targeting_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,asgpr_receptor_copies_per_hepatocyte_proxy,integer,196,1,500000,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_cluster_valency_proxy,categorical,196,2,triantennary_or_trivalent | tetravalent_or_alternative_cluster,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_cluster_position_proxy,categorical,196,1,3prime_sense_strand_siRNA_or_5prime_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,naked_ASO_nonparenchymal_liver_uptake_pct_proxy,float,196,1,0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_ASO_hepatocyte_uptake_pct_proxy,float,196,175,0.8699 | 0.8486 | 0.9045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_ASO_or_siRNA_potency_improvement_fold_proxy,float,196,196,71.9496 | 19.3095 | 9.5914,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_siRNA_ESC_or_ESCplus_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_ESCplus_seed_offtarget_mitigation_score_proxy,float,196,188,0.9113 | 0.4739 | 0.538,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,reversir_reversal_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_endosomal_escape_efficiency_pct_proxy,float,196,191,0.4531 | 0.8499 | 0.3083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_monomer_loss_hours_proxy,float,196,195,1.0809 | 0.9203 | 0.7765,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_cluster_arm_cleavage_hours_proxy,float,196,196,4.2887 | 3.9335 | 4.0763,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,asgpr_saturation_high_dose_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_kidney_distribution_shift_score_proxy,float,196,192,0.3328 | 0.4119 | 0.3322,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_liver_to_kidney_distribution_ratio_proxy,float,196,195,2.608 | 1.9805 | 1.8949,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,registered_givosiran_context_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,clinical_pipeline_conjugate_count_proxy,integer,196,1,29,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,clinical_ALT_injection_reaction_monitoring_score_proxy,float,196,193,0.4598 | 0.5116 | 0.3931,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_delivery_therapeutic_window_score_proxy,float,196,185,0.8778 | 0.7685 | 0.6845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,galnac_delivery_review_source_id,categorical,196,1,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_20,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,value_origin,categorical,196,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_liver_delivery_review_context.csv,assumption_id,categorical,196,1,ASM_036,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,galnac_lnp_mkk4_state,categorical,1120,8,not_modeled | biocompatible_GalNAc_LNP_siMKK4_delivery | GalNAc_LNP_siMKK4_ACLF_regeneration_resc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_therapeutic_goal,categorical,1120,3,not_applicable | promote_liver_regeneration | injury_model_background,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dual_targeting_context,categorical,1120,2,not_applicable | LNP_liver_tropism_plus_GalNAc_ASGPR_hepa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_target_selectivity_mkk7_avoidance_score,float,1120,53,0.0 | 0.82337 | 0.77541,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dotap_mol_pct_proxy,integer,1120,2,0.0 | 50.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dspc_mol_pct_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_cholesterol_mol_pct_proxy,integer,1120,2,0.0 | 40.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_galnac_peg_dspe_mol_pct_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_np_ratio_proxy,integer,1120,2,0.0 | 6.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_particle_size_nm_proxy,float,1120,53,0.0 | 183.89947 | 171.3536,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_zeta_potential_mV_proxy,float,1120,53,0.0 | 25.43536 | 23.91005,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_pdi_proxy,float,1120,53,0.0 | 0.16935 | 0.17381,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_encapsulation_efficiency_pct_proxy,float,1120,38,0.0 | 92.87302 | 96.12801,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_gene_loading_pct_proxy,float,1120,37,0.0 | 2.72346 | 2.64053,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_rnase_protection_score_proxy,float,1120,42,0.0 | 0.88187 | 0.9479,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_siRNA_release_96h_pct_proxy,float,1120,31,0.0 | 40.59554 | 43.90138,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_hemolysis_pct_proxy,float,1120,34,0.0 | 1.47446 | 2.54001,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_tropism_score,float,1120,53,0.0 | 0.84115 | 0.91175,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_hepatocyte_targeting_score,float,1120,53,0.0 | 0.91341 | 0.93345,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_kupffer_endothelial_offtarget_reduction_score,float,1120,50,0.0 | 0.79066 | 0.81439,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_mkk4_knockdown_score,float,1120,47,0.0 | 0.85347 | 0.55407,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_p38_reduction_score_proxy,float,1120,50,0.0 | 0.80704 | 0.44502,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_mkk7_activation_score_proxy,float,1120,53,0.0 | 0.79779 | 0.68029,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_jnk1_activation_score_proxy,float,1120,53,0.0 | 0.86172 | 0.51985,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_elk1_activation_score_proxy,float,1120,53,0.0 | 0.81428 | 0.65998,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_atf2_activation_score_proxy,float,1120,53,0.0 | 0.7893 | 0.6173,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_aml12_cell_viability_recovery_pct_proxy,float,1120,53,0.0 | 73.89268 | 63.88135,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_ki67_proliferation_score_proxy,float,1120,51,0.0 | 0.80589 | 0.69453,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_regeneration_score_proxy,float,1120,51,0.0 | 0.80589 | 0.69453,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_apoptosis_reduction_score_proxy,float,1120,53,0.0 | 0.64719 | 0.42503,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_function_recovery_score_proxy,float,1120,53,0.0 | 0.59367 | 0.57237,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_aclf_model_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_direct_hepatotoxicity_modifier,float,1120,47,0.0 | 0.16181 | 0.15177,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_context_confidence_score,float,1120,53,0.0 | 0.89122 | 0.93403,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,context_note,categorical,1120,3,No GalNAc-LNP-siMKK4 context modeled for | Supporting GalNAc-LNP-siMKK4 hepatocyte  | Supporting GalNAc-LNP-siMKK4 delivery/re,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_lnp_mkk4_liver_regeneration.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,galnac_rbc_ev_state,categorical,1120,5,not_modeled | GalNAc_RBC_EV_ASGPR_hepatocyte_targeted_ | RBC_EV_GalNAc_miR155_ASO_ALF_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,galnac_rbc_ev_context_type,categorical,1120,6,not_modeled | delivery_biosafety | ALF_miR155_ASO_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_particle_size_nm_proxy,float,1120,17,0.0 | 120.2949 | 117.77362,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_galnac_surface_anchor_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_asgpr_hepatocyte_uptake_score_proxy,float,1120,15,0.0 | 0.87888 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_kupffer_relative_uptake_score_proxy,float,1120,17,0.0 | 0.19799 | 0.10241,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_freeze_thaw_stability_score_proxy,float,1120,17,0.0 | 0.90936 | 0.97,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_payload_type,categorical,1120,6,not_modeled | GalNAc_RBC_EV_only | GalNAc_miR155_ASO_on_RBC_EV,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_pj34_loading_ug_per_100ug_ev_proxy,float,1120,13,0.0 | 5.50223 | 4.3153,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_mir155_knockdown_score_proxy,float,1120,14,0.0 | 0.08241 | 0.73229,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_rab7_knockdown_score_proxy,float,1120,14,0.0 | 0.18016 | 0.04953,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_parp1_par_reduction_score_proxy,float,1120,13,0.0 | 0.097 | 0.67905,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_alf_alt_ast_reduction_score_proxy,float,1120,8,0.0 | 0.72592 | 0.85525,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_panoptosis_reduction_score_proxy,float,1120,8,0.0 | 0.84345 | 0.76362,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_nafld_steatosis_reduction_score_proxy,float,1120,7,0.0 | 0.61844 | 0.70215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_hcc_drug_retention_score_proxy,float,1120,8,0.0 | 0.74295 | 0.8428,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_hcc_tumor_suppression_score_proxy,float,1120,8,0.0 | 0.71941 | 0.66561,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_vital_organ_toxicity_score_proxy,float,1120,17,0.0 | 0.08768 | 0.04857,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_alt_ast_no_toxicity_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_histopathology_no_toxicity_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,rbc_ev_context_confidence_score,float,1120,17,0.0 | 0.94196 | 0.91389,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,context_note,categorical,1120,3,Supporting GalNAc-RBC-EV liver delivery  | Supporting GalNAc-modified RBC-EV hepato | No GalNAc-RBC-EV context modeled.,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_rbc_ev_liver_delivery.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,ALT_AST_toxicity_signal_score_proxy,float,5,3,0.08 | 0.12 | 0.1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,CEBPB_knockdown_score_proxy,float,5,2,0.8 | 0.45,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,albumin_bilirubin_function_context,categorical,5,2,not_primary_endpoint | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,assumption_id,categorical,5,1,ASM_082,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,challenge_alignment,categorical,5,1,directly supports ability-to-solve and p,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,dose_or_regimen_context,string,5,3,dose_response | subcutaneous_10mgkg | continued_HFD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,inflammation_score_proxy,float,5,5,0.2 | 0.3 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,liver_homeostasis_benefit_score_proxy,float,5,5,0.55 | 0.6 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,model_system,string,5,5,primary_mouse_hepatocytes | HFD_mouse_liver | HFD_mouse_MASLD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,modeling_role,string,5,5,in_vitro_target_engagement | in_vivo_hepatocyte_target_engagement | steatosis_reversal_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,module_id,categorical,5,1,GalNAc_siCEBPB_MASLD_liver_homeostasis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,notes,categorical,5,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,oligo_modality,categorical,5,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,safety_interpretation,categorical,5,1,unchanged_ALT_AST_no_hepatotoxicity_sign,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,scenario_id,string,5,5,PMH_dose_response_0_001_to_5uM | HFD_mouse_SC_10mgkg_target_knockdown | HFD_mouse_steatosis_reduction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,source_id,categorical,5,1,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTAS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,steatosis_score_proxy,float,5,5,0.2 | 0.35 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,study_context,categorical,5,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,target_gene,categorical,5,1,CEBPB,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicebpb_masld_liver_homeostasis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,CIDEB_knockdown_score_proxy,float,6,6,0.92 | 0.94 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,MASH_steatosis_or_fibrosis_benefit_score_proxy,float,6,4,0.55 | 0.74 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,assumption_id,categorical,6,1,ASM_080,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,challenge_alignment,categorical,6,1,directly supports ability-to-solve and i,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,chemical_design_features,categorical,6,1,2prime-OMe|2prime-F|5prime-VP|isoGNA_spe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,dose_or_regimen_context,string,6,5,screening | GalNAc_modified | ASGPR_free_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,model_system,string,6,5,Hep3B | primary_mouse_hepatocytes | AAV8_hCIDEB_mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,modeling_role,string,6,6,initial_sequence_screen | lead_candidate_screen | cross_species_hepatocyte_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,module_id,categorical,6,1,GalNAc_siCIDEB_MASH_safety_efficacy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,observed_toxicity_score_proxy,float,6,5,0.2 | 0.16 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,offtarget_assessment_included,categorical,6,1,yes_transcriptome_or_reporter_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,oligo_modality,categorical,6,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,residual_inflammation_or_liver_stress_score_proxy,float,6,5,0.3 | 0.24 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,safety_interpretation,categorical,6,2,disease_model_residual_stress_context | minimal_offtarget_and_no_observed_toxici,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,scenario_id,string,6,6,screening_Hep3B_unconjugated_siRNA | modified_GalNAc_siCIDEB_Hep3B | primary_mouse_hepatocyte_free_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,source_id,categorical,6,1,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,target_gene,categorical,6,1,CIDEB,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,target_specificity_score_proxy,float,6,5,0.65 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sicidEB_mash_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,analyte,categorical,150,5,Givosiran | Givosiran_AS_Nminus1_3prime_metabolite | Lumasiran,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,bioanalysis_quality_class_generated,categorical,150,3,robust_generalizable | sequence_specific_or_costly | needs_optimization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,cost_complexity_score_proxy,float,150,3,0.25 | 0.65 | 0.85,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,judging_alignment,categorical,150,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,lcms_platform,categorical,150,1,QTRAP_MRM_or_Orbitrap_HRMS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,lloq_ng_per_mL_proxy,float,150,150,3.19469 | 4.12879 | 3.99932,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,matrix_interference_score_proxy,float,150,150,0.12336 | 0.13228 | 0.05311,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,modeling_value,categorical,150,1,measurement_quality_PK_TK_reproducibilit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,module_record_id,identifier,150,150,GALNAC_LCMS_0001 | GALNAC_LCMS_0002 | GALNAC_LCMS_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,parent_metabolite_discrimination_flag,integer,150,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,pk_parameter_suitability_score_proxy,float,150,103,0.98747 | 0.9771 | 0.98976,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,precision_cv_proxy,float,150,150,0.09024 | 0.09879 | 0.13341,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,recovery_fraction_proxy,float,150,150,0.74192 | 0.71689 | 0.71235,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,sample_matrix,categorical,150,2,rat_plasma | human_plasma_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,sample_preparation_method,categorical,150,3,DPPT_optimized_ACN | SPE_context | hybridization_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,source_id,categorical,150,1,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_lcms_bioanalysis.csv,value_origin,categorical,150,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,oligo_id,string,319,319,CTRL_OLIGO_NEG_SPHEROID_TOLERATED | CTRL_OLIGO_POS_HIGH_OFFTARGET | CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,control_id,string,319,25,CTRL_NEG_HUMAN_LIVER_SPHEROID_TOLERATED | CTRL_POS_HIGH_OFFTARGET | CTRL_POS_TRANSCRIPTOMIC_STRESS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,source_id,string,319,58,LIVER_SPHEROID_SCHOLTEN_2026 | MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RO7239958_GERETTI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,target_gene,string,319,67,AHSA1 | generic_offtarget | generic_stress_pathway,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,modality,string,319,31,GalNAc-siRNA | siRNA | gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,cell_model,string,319,31,human_liver_spheroid | HepaRG | clinical_liver_readout_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,galnac_sirna_nonclinical_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,galnac_sirna_safety_state,categorical,319,5,distribution_accumulation_liver_kidney_R | rat_sensitive_exaggerated_dose_screen | seed_region_offtarget_rat_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,ESC_chemistry_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,ASGPR_hepatocyte_receptor_capacity_proxy,float,319,269,0.9059 | 0.9746 | 0.9503,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,extrahepatic_distribution_fraction_proxy,float,319,242,0.0164 | 0.0 | 0.0129,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,terminal_PS_linkage_count_proxy,integer,319,1,4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,two_prime_OMe_full_modification_context,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,two_prime_F_modification_context,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,supratherapeutic_dose_multiple_proxy,integer,319,6,180.0 | 30.0 | 60.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,rat_hepatotoxicity_sensitivity_score_proxy,float,319,304,0.5943 | 0.5322 | 0.6673,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,monkey_adversity_score_proxy,float,319,308,0.3056 | 0.1073 | 0.3867,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,seed_region_offtarget_hepatotoxicity_risk_proxy,float,319,290,0.0463 | 0.1305 | 0.2295,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,seed_region_destabilization_mitigation_applicable,integer,319,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,centrilobular_degeneration_necrosis_score_proxy,float,319,290,0.1815 | 0.2091 | 0.2952,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,ALT_fold_ULN_exaggerated_dose_proxy,float,319,316,1.4791 | 1.4128 | 1.2725,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,kidney_elimination_accumulation_score_proxy,float,319,298,0.6186 | 0.151 | 0.3023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,renal_function_change_score_proxy,float,319,94,0.1115 | 0.0 | 0.0008,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,RES_lymph_node_macrophage_accumulation_score_proxy,float,319,287,0.4056 | 0.0 | 0.1784,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,partial_complete_reversibility_score_proxy,float,319,304,0.6203 | 0.6824 | 0.6564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,genotoxicity_negative_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,safety_pharmacology_negative_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,galnac_sirna_platform_safety_modifier,float,319,308,0.2112 | 0.1945 | 0.2843,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,galnac_sirna_platform_safety_label,categorical,319,3,selected_low_tox_platform_profile | seed_offtarget_hepatotox_screen_fail | distribution_monitoring_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,value_origin,categorical,319,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,assumption_id,categorical,319,1,ASM_034,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_nonclinical_safety.csv,record_origin,categorical,319,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,assumption_id,categorical,6,1,ASM_110,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,delivery_or_targeting_score_proxy,float,6,6,0.96 | 0.9 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,modality_or_platform,string,6,5,GalNAc-siRNA | modified_GalNAc-siRNA | GalNAc-siRNA_design,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,model_system,string,6,6,rat_supratherapeutic_toxicology | rat_mouse_hepatotoxicity_rescue | liver_concentration_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,modeling_role,string,6,6,direct_ALT_AST_bilirubin_and_histopathol | RISC_loading_required_but_not_sufficient | chemistry_and_exposure_not_primary_drive,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,module_id,categorical,6,1,GalNAc_siRNA_seed_offtarget_rat_hepatoto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,primary_effect_score_proxy,float,6,6,0.92 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,scenario_id,string,6,6,hepatotoxic_GalNAc_siRNA_repeat_dose_scr | antisense_5prime_capping_blocks_RISC_loa | liver_exposure_matched_RISC_inactive_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,source_id,categorical,6,1,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,toxicity_or_safety_signal_proxy,float,6,5,0.44 | 0.18 | 0.14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_offtarget_rat_hepatotoxicity.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,assumption_id,categorical,6,1,ASM_123,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,delivery_or_targeting_score_proxy,float,6,5,0.92 | 0.88 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,modality_or_platform,string,6,6,GalNAc_siRNA_PK_mechanism | PK_PD_mechanism | modeling_rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,model_system,string,6,6,whole_body_PBPK_hepatocyte_ASGPR_model | GalNAc_siRNA_RISC_mRNA_target_protein_mo | cross_species_PK_PD_translation_framewor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,modeling_role,string,6,6,liver_specific_uptake_and_ASGPR_transpor | RISC_mRNA_knockdown_target_protein_PD_co | preclinical_to_clinical_translation_cont,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,module_id,categorical,6,1,GalNAc_siRNA_whole_body_PBPK_PD_species_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,primary_effect_score_proxy,float,6,5,0.84 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,scenario_id,string,6,6,ASGPR_hepatocyte_targeted_uptake | endosomal_escape_RISC_loading_PD | mouse_monkey_human_species_translation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,source_id,categorical,6,1,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,toxicity_or_safety_signal_proxy,float,6,4,0.24 | 0.22 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pbpk_pd_species_translation.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,assumption_id,categorical,6,1,ASM_107,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,delivery_or_targeting_score_proxy,float,6,6,0.32 | 0.3 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,mechanism_or_specificity_score_proxy,float,6,5,0.88 | 0.76 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,modality_or_platform,string,6,5,siRNA_design | siRNA | GalNAc-siRNA_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,model_system,string,6,6,PCSK9_mRNA_candidate_library | HEK293T_reporter_model | PCSK9_positive_control_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,modeling_role,string,6,6,sequence_design_and_offtarget_prediction | initial_activity_screening_context | approved_like_comparator_anchor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,module_id,categorical,6,1,GalNAc_siRNA_PCSK9_design_and_synthesis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,scenario_id,string,6,6,in_silico_siRNA_candidate_selection | unmodified_siRNA_screening | Inclisiran_analog_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,source_id,categorical,6,1,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,toxicity_or_safety_signal_proxy,float,6,3,0.16 | 0.18 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_pcsk9_liquid_phase_design.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,assumption_id,categorical,7,1,ASM_124,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,hepatotoxicity_signal_score_proxy,float,7,7,0.4 | 0.92 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,mechanistic_role,string,7,7,on_target_catalytic_cleavage | seed_off_target_miRNA_like_repression | control_ARGONAUTE_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,modeled_readout_family,categorical,7,1,ALT_AST_liver_function_tests_transcripto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,module_id,categorical,7,1,GalNAc_siRNA_RISC_offtarget_hepatotoxici,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,notes,string,7,7,AGO2 knockdown reduces intended GalNAc-s | AGO2 is modeled as a major mediator of u | AGO1/AGO4 knockdown is modeled as less p,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,off_target_activity_dependency_score_proxy,float,7,7,0.9 | 0.88 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,on_target_activity_dependency_score_proxy,float,7,7,0.95 | 0.86 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,protective_knockdown_or_mitigation_score_proxy,float,7,7,0.3 | 0.72 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,risc_component_or_feature,string,7,6,AGO2 | AGO1_AGO4 | TNRC6A_TNRC6B,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,scenario_id,string,7,7,AGO2_on_target_requirement | AGO2_off_target_hepatotoxicity_requireme | AGO1_AGO4_not_primary_protective,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,source_id,categorical,7,1,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+galnac_sirna_risc_offtarget_mechanism.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,ALT_AST_liability_fold_proxy,float,6,6,3.8 | 3.1 | 1.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,RNase_H1_dependency,string,6,3,yes | attenuated_by_RNaseH1_knockdown | yes_but_sequence_selective,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,affinity_modification,string,6,3,LNA | cEt | 2-MOE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,challenge_alignment,categorical,6,1,"directly supports ability-to-solve, rigo",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,gapmer_length_nt_proxy,integer,6,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,high_affinity_modification_flag,integer,6,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,intended_target_context,categorical,6,1,F7_F11_SOD1_PTEN_BIRC5_style_mouse_or_hu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,long_transcript_susceptibility_proxy,float,6,6,0.78 | 0.7 | 0.19,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,module_id,categorical,6,1,gapmer_RNaseH1_long_pre_mRNA_hepatotoxic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,notes,categorical,6,1,Generated mechanism row; does not reprod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,oligo_class,categorical,6,1,RNase_H_gapmer_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,pre_mRNA_length_enrichment_bin,string,6,3,very_long | mixed | short_to_mid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,scenario_id,string,6,6,LNA_high_affinity_toxic | cEt_high_affinity_toxic | MOE_gapmer_lower_liability,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,scenario_role,string,6,4,positive_control | negative_comparator | mechanistic_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,source_id,categorical,6,1,BUREL_GAPMER_RNASEH1_LONG_PREMRNA_HEPATO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,transcriptome_selectivity_index_proxy,float,6,6,0.18 | 0.24 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,transcriptomic_signature_timing,categorical,6,2,source_grounded_mechanism_proxy | concurrent_with_on_target_reduction_and_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,very_long_pre_mRNA_offtarget_reduction_proxy,float,6,6,0.82 | 0.76 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gapmer_rnaseh1_long_premrna_hepatotox.csv,wing_design_proxy,categorical,6,2,3-10-3 high affinity wings | MOE gapmer comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+generated_records.csv,generated_record_id,string,17920,17920,GEN_CTRL_OLIGO_NEG_VEHICLE_MOCK | GEN_CTRL_OLIGO_NEG_LOW_RISK | GEN_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,record_type,categorical,17920,2,oligo_level_record | toxicity_readout_record,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,primary_id,string,17920,17920,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,source_id,string,17920,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,control_id,string,17920,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,record_origin,categorical,17920,1,dbbun_generated,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,value_origin,categorical,17920,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,measured_experimental_value,categorical,17920,1,no,Aggregate counts and provenance summary of generated records by table.
+generated_records.csv,license_for_generated_output,categorical,17920,1,CC BY 4.0,Aggregate counts and provenance summary of generated records by table.
+gys1_aso_pompe_skeletal_muscle.csv,assumption_id,categorical,6,1,ASM_115,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,delivery_or_targeting_score_proxy,float,6,6,0.62 | 0.6 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,mechanism_or_specificity_score_proxy,float,6,6,0.88 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,modality_or_platform,string,6,6,PS-cEt_gapmer_ASO | ASO_substrate_reduction | ASO_plus_enzyme_replacement,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,model_system,string,6,6,Gaa_knockout_mouse_skeletal_muscle | Pompe_myopathy_mouse_model | combination_therapy_mouse_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,modeling_role,string,6,6,extrahepatic_ASO_target_knockdown_contex | tissue_function_response_context | combination_intervention_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,module_id,categorical,6,1,GYS1_ASO_Pompe_skeletal_muscle_effects,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,primary_effect_score_proxy,float,6,6,0.82 | 0.84 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,scenario_id,string,6,6,systemic_Gys1_gapmer_ASO_knockdown | skeletal_muscle_glycogen_reduction | ERT_ASO_combination,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,source_id,categorical,6,1,WEISS_GYS1_ASO_POMPE_SKELETAL_MUSCLE_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,toxicity_or_safety_signal_proxy,float,6,3,0.24 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_aso_pompe_skeletal_muscle.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,oligo_id,string,4,4,OLIGO_CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVA | OLIGO_CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_RE | OLIGO_CTRL_CONTEXT_GYS1_ASO_ERT_COMBINAT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,source_id,categorical,4,1,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,control_id,string,4,4,CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION | CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTIO | CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,gys1_pompe_state,string,4,4,Gys1_ASO_systemic_tolerability_low_ALT_A | Pompe_Gys1_substrate_reduction_ASO | Pompe_Gys1_ASO_plus_ERT_combination,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,therapy_context,string,4,3,GYS1_ASO_alone | GYS1_ASO_plus_rhGAA_ERT | specificity_screening_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,treatment_timing_context,string,4,4,preclinical_systemic_ASO_tolerability | early_or_reversal_treatment_context | combination_after_ASO_lead_in,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,aso_gapmer_length_nt,integer,4,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,aso_backbone,categorical,4,1,phosphorothioate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,aso_sugar_modification,categorical,4,1,2prime_constrained_ethyl_cEt,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,gapmer_architecture,categorical,4,1,3_10_3_cEt_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,RNase_H1_mechanism_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,subcutaneous_weekly_dosing_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,dose_mg_kg_week_proxy,integer,4,1,25.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,treatment_duration_weeks_proxy,integer,4,1,16.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,ERT_combination_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,rhGAA_ERT_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,Gys1_mRNA_knockdown_fraction_proxy,float,4,4,0.86 | 0.82 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,GYS1_protein_reduction_fraction_proxy,float,4,4,0.94 | 0.9 | 0.98,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,GYS1_GYS2_isoform_specificity_score_proxy,float,4,4,0.8 | 0.784 | 0.81,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,GYS2_liver_spared_score_proxy,float,4,3,0.8808 | 0.8779 | 0.8845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,quadriceps_glycogen_reduction_fraction_proxy,float,4,4,0.55 | 0.48 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,heart_glycogen_reduction_fraction_proxy,float,4,4,0.531 | 0.5016 | 0.8286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,autophagy_marker_rescue_score_proxy,float,4,4,0.5575 | 0.512 | 0.8395,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,LAMP1_LC3_p62_rescue_context_score_proxy,float,4,4,0.5575 | 0.512 | 0.8395,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,motor_function_preservation_score_proxy,float,4,4,0.5505 | 0.511 | 0.804,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,ALT_fold_proxy,float,4,3,1.0 | 1.03 | 1.02,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,AST_fold_proxy,float,4,3,1.0 | 1.03 | 1.02,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,BUN_fold_proxy,float,4,2,1.0 | 1.01,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,CK_fold_proxy,float,4,4,1.02 | 0.92 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,organ_weight_change_abs_proxy,float,4,4,0.04 | 0.06 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,systemic_tolerability_score_proxy,float,4,4,0.95 | 0.9336 | 0.944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,ALT_AST_safety_monitoring_score_proxy,float,4,3,1.0 | 0.985 | 0.99,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,preprint_caution_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,direct_oligotox_hepatotoxicity_relevance,categorical,4,1,supporting_not_direct,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,phase2_alignment,categorical,4,1,experimental_design_negative_controls_tr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,confidence_score,float,4,4,0.58 | 0.56 | 0.57,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+gys1_pompe_aso_srt_context.csv,assumption_id,categorical,4,1,ASM_040,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_state,categorical,1120,4,baseline_non_HBV_RNAi_context | VIR2218_ESCplus_seed_modified_low_ALT_or | ALN_HBV_parent_seed_offtarget_ALT_elevat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_therapeutic_context,categorical,1120,4,not_applicable | VIR-2218_ESCplus_healthy_volunteer | ALN-HBV_parent_ESC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_target_region,categorical,1120,2,not_applicable | HBV_X_DR2_region_all_major_transcripts,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_ESCplus_seed_modification,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_gna_seed_substitution,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_seed_mediated_offtarget_reduction_score,float,1120,19,0.0 | 0.92625 | 0.02781,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_predicted_offtarget_gene_dysregulation_score,float,1120,15,0.0 | 0.02441 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_humanized_mouse_hALT_signal_proxy,float,1120,19,0.0 | 45.6359 | 97.93101,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_healthy_volunteer_ALT_elevation_pct_proxy,float,1120,8,0.0 | 28.0 | 24.47401,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_highest_ALT_xULN_proxy,float,1120,19,1.0 | 1.27008 | 7.20565,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_ALT_no_bilirubin_functional_impairment_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_clinical_dose_mg_proxy,integer,1120,7,0.0 | 100.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_dose_mg_per_kg_proxy,float,1120,14,0.0 | 1.56127 | 3.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_number_of_doses_proxy,integer,1120,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_dosing_interval_weeks_proxy,integer,1120,2,0.0 | 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_reduction_week20_log10_proxy,float,1120,7,0.0 | -1.88006 | -0.47728,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_reduction_week48_log10_proxy,float,1120,7,0.0 | -1.04078 | -0.07665,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_below_100_IU_ml_probability_proxy,float,1120,3,0.0 | 0.7 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_functional_cure_observed_flag,integer,1120,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_safety_modifier,float,1120,17,0.0 | -0.47282 | 1.75,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_antiviral_activity_score,float,1120,7,0.0 | 1.05 | 0.28926,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,hbv_rnai_confidence_score,float,1120,19,0.0 | 0.84624 | 0.69747,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,context_note,categorical,1120,3,not_applicable | VIR-2218/ALN-HBV generated proxy fields  | HBV RNAi ESC+ seed-region context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,value_origin,categorical,1120,3,not_reported | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hbv_rnai_escplus_safety.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,oligo_id,string,3,3,OLIGO_CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_S | OLIGO_CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN | OLIGO_CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,source_id,categorical,3,1,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,control_id,string,3,3,CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL | CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTRE | CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,target_gene,categorical,3,1,HOXB7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,oligo_modality,categorical,3,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hnp_hoxb7_state,string,3,3,HNP_siHOXB7_low_hepatic_signal | HOXB7_siRNA_tamoxifen_cotreatment | calcium_phosphate_HNP_siRNA_delivery_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,breast_cancer_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,calcium_phosphate_hybrid_nanoparticle_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,PEG_pGlu_shell_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,HOXB7_siRNA_payload_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,tamoxifen_cotreatment_flag,integer,3,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,mean_hydrodynamic_diameter_nm_proxy,float,3,2,74.4 | 70.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,PDI_proxy,float,3,2,0.1 | 0.07,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,zeta_potential_mV_proxy,float,3,1,-1.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,siRNA_encapsulation_efficiency_pct_proxy,float,3,1,52.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,acidic_pH_destabilization_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,endosomal_escape_context_score,float,3,1,0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hemolysis_pct_proxy,float,3,2,0.4 | 0.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,MCF7_viability_48h_pct_proxy,float,3,1,85.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,migration_free_area_48h_pct_proxy,integer,3,1,52.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,advanced_tumor_survival_pct_proxy,integer,3,3,80.0 | 100.0 | 85.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,advanced_tumor_control_score_proxy,float,3,3,0.66 | 0.78 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,HOXB7_mRNA_expression_pct_of_control_proxy,integer,3,3,50.0 | 68.0 | 72.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,ALT_U_L_proxy,float,3,3,60.4 | 55.7 | 58.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,AST_U_L_proxy,float,3,3,218.0 | 175.5 | 190.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,WBC_systemic_tolerability_context_score,float,3,2,0.72 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hepatotoxicity_safety_context_label,categorical,3,1,low_direct_hepatic_signal_supporting_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hnp_hoxb7_context_confidence_score,float,3,1,0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,assumption_id,categorical,3,1,ASM_030,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnp_hoxb7_tamoxifen_nanoparticle_context.csv,record_origin,categorical,3,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,administration_context,string,5,4,systemic | systemic_in_vivo_screen | systemic_PDX_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,assumption_id,categorical,5,1,ASM_086,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,challenge_alignment,categorical,5,1,supports delivery and biodistribution ri,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,delivery_related_toxicity_signal_proxy,float,5,4,0.22 | 0.2 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,formulation_or_screen,string,5,3,standard_LNP_reference | DNA_barcoded_LNP_library | LNPHNSCC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,in_vivo_screening_relevance_score_proxy,float,5,4,0.7 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,liver_detargeting_context,categorical,5,2,no_or_reference | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,liver_hepatocyte_delivery_score_proxy,float,5,5,0.85 | 0.55 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,modeling_role,string,5,5,liver_offtarget_reference | high_throughput_discovery_context | tumor_delivery_liver_detargeting_candida,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,module_id,categorical,5,1,hnscc_lnp_liver_detargeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,notes,categorical,5,1,Generated delivery-biodistribution scena,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,payload_context,categorical,5,1,mRNA_or_barcoded_nucleic_acid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,scenario_id,string,5,5,standard_liver_tropic_LNP | barcoded_94_LNP_in_vivo_screen | LNPHNSCC_tumor_tropic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,source_id,categorical,5,1,HUAYAMARES_HNSCC_LNP_TUMOR_TROPISM_LIVER,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,tumor_delivery_score_proxy,float,5,5,0.35 | 0.55 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hnscc_lnp_liver_detargeting.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,assumption_id,categorical,7,1,ASM_127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,endpoint_family,string,7,7,ALT_AST | ALD_NAFLD_cirrhosis | NASH_histology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,evidence_confidence_score_proxy,float,7,6,0.82 | 0.84 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,model_system,string,7,6,human_genetics | human_EHR_exome_cohorts | human_liver_samples,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,module_id,categorical,7,1,HSD17B13_genetics_ASO_translation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,notes,string,7,7,loss_of_function_variant_associated_with | protective_association_across_chronic_li | variant_associated_with_reduced_NASH_ris,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,protective_or_target_rationale_score_proxy,float,7,6,0.86 | 0.84 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,scenario_id,string,7,7,HSD17B13_rs72613567_TA_ALT_AST_lower | reduced_chronic_liver_disease_risk | NASH_not_steatosis_histology_distinction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,source_id,categorical,7,2,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_201 | MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,toxicity_or_limitation_score_proxy,float,7,5,0.12 | 0.1 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,translation_relevance_score_proxy,float,7,6,0.76 | 0.8 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_genetics_aso_translation.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_clinical_state,categorical,1120,7,baseline_non_HSD17B13_clinical_context | MASH_400mg_highest_dose_max_mRNA_knockdo | healthy_adult_single_ascending_dose_PK_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_genotype_context,categorical,1120,4,not_applicable | no_homozygous_protective_variant | risk_allele_carrier_or_unknown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_risk_allele_status,categorical,1120,4,not_applicable | HSD17B13_risk_allele_present_or_unknown | heterozygous_protective_possible,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,pnpla3_rs738409_context,categorical,1120,4,not_applicable | PNPLA3_risk_status_balanced | PNPLA3_I148M_risk_allele_possible,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_like_dose_mg_proxy,integer,1120,6,0.0 | 400.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_number_of_doses_proxy,integer,1120,3,0 | 2 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_dosing_interval_weeks_proxy,integer,1120,2,0.0 | 12.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_route,categorical,1120,2,not_applicable | subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ASGPR_GalNAc_delivery_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_HSD17B13_mRNA_change_month6_pct_proxy,float,1120,77,0.0 | -81.88884 | -70.27332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_HSD17B13_mRNA_change_month12_pct_proxy,float,1120,36,0.0 | -28.54278 | -2.6684,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ALT_change_day169_pct_proxy,float,1120,90,0.0 | -23.55218 | -4.41809,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_AST_change_day169_pct_proxy,float,1120,90,0.0 | -10.11747 | -4.6387,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_no_DILI_observed_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_injection_site_reaction_pct_proxy,integer,1120,3,0.0 | 6.0 | 11.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ADA_incidence_pct_proxy,float,1120,3,0.0 | 2.8 | 2.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_NAS_change_direction_proxy,categorical,1120,6,not_applicable | numerically_improved_NAS_lobular_inflamm | not_applicable_healthy_adult,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_lobular_inflammation_ballooning_improvement_proxy,float,1120,67,0.0 | 0.33152 | -0.1682,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_fibrosis_stage_improvement_proxy,float,1120,69,0.0 | 0.48817 | 0.02754,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_Tmax_hours_proxy,float,1120,76,0.0 | 4.2037 | 5.41745,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_plasma_half_life_hours_proxy,float,1120,76,0.0 | 4.49061 | 6.59521,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_parent_urine_excretion_pct_proxy,float,1120,76,0.0 | 24.50557 | 32.36374,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_active_metabolite_urine_excretion_pct_proxy,float,1120,76,0.0 | 1.53607 | 0.61222,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ASGPR_saturation_context,categorical,1120,4,not_applicable | transient_ASGPR_saturation_possible_high | ASGPR_mediated_hepatocyte_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_PD_durability_score_proxy,float,1120,74,0.0 | 0.81889 | 0.40617,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_safety_modifier,float,1120,6,0.0 | -0.54 | -0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_benefit_modifier,float,1120,41,0.0 | 0.81889 | 0.04,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_confidence_score,float,1120,87,0.0 | 0.90878 | 0.78454,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,context_note,categorical,1120,3,HSD17B13/rapirosiran clinical context no | rapirosiran/HSD17B13 clinical PK-PD safe | HSD17B13/rapirosiran clinical context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hsd17b13_rapirosiran_clinical_pd.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,assumption_id,categorical,6,1,ASM_113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,delivery_or_targeting_score_proxy,float,6,5,0.84 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,mechanism_or_specificity_score_proxy,float,6,5,0.78 | 0.74 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,modality_or_platform,string,6,6,nebulized_siRNA_HNP | delivery_physics_context | biomimetic_LNP_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,model_system,string,6,6,pulmonary_fibrosis_mouse_lung | fibrotic_airway_mucus_barrier | alveolar_macrophage_targeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,modeling_role,string,6,6,extrahepatic_siRNA_delivery_breadth | barrier_penetration_modeling_context | macrophage_affinity_and_delivery_specifi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,module_id,categorical,6,1,nebulized_HNP_TGFb1_siRNA_pulmonary_fibr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,primary_effect_score_proxy,float,6,6,0.8 | 0.66 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,scenario_id,string,6,6,aerosol_HNP_TGFb1_siRNA_delivery | hydrogen_mucus_barrier_disruption | apoptotic_T_cell_membrane_biomimetic_tar,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,source_id,categorical,6,1,LIU_HYDROGEN_HNP_TGFB1_SIRNA_PULMONARY_F,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,toxicity_or_safety_signal_proxy,float,6,3,0.2 | 0.18 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,oligo_id,identifier,44,44,OLIGO_0000010 | OLIGO_0000024 | OLIGO_0000041,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,control_id,categorical,44,5,NON_CONTROL_GENERATED_RECORD | CTRL_POS_IFNA_DISULFIDPTOSIS_HCC | CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,source_id,categorical,44,20,BI_IFNA_DISULFIDPTOSIS_HCC_2026 | KIM_NANP_LIPID_LIVER_TARGETING_2026 | BOSCO_INCLISIRAN_FH_REALWORLD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,target_gene,string,44,30,CYP2E1 | APOB | PSMD9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,modality,categorical,44,20,DCA_conjugated_asymmetric_siRNA | GalNAc-siRNA | GalNAc-LNA-ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,cell_model,categorical,44,12,liver_on_chip | HepG2 | rat_primary_hepatocytes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,ifna_disulfidptosis_context_flag,integer,44,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,ifna_disulfidptosis_state,categorical,44,5,IFN_alpha_disulfidptosis_like_HCC_stress | background | IFN_alpha_candidate_ISG_upregulation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,hcc_cell_line_context,categorical,44,5,generated_liver_context | HepG2 | IFN_alpha_treated_HepG2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,ifna_concentration_IU_ml_proxy,integer,44,4,1000.0 | 500.0 | 250.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,ifna_duration_h_proxy,integer,44,3,48.0 | 72.0 | 24.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,glucose_availability_state,categorical,44,2,glucose_starvation_or_glucose_uptake_lim | standard_glucose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,high_molecular_weight_protein_aggregation_score_proxy,float,44,44,0.7346 | 0.7778 | 0.8879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,disulfide_bond_accumulation_score_proxy,float,44,44,0.7346 | 0.7778 | 0.8879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,NADPH_depletion_score_proxy,float,44,44,0.7666 | 0.8248 | 0.6893,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,F_actin_collapse_score_proxy,float,44,42,0.5946 | 0.791 | 0.7048,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,D_penicillamine_rescue_score_proxy,float,44,43,0.0637 | 0.2322 | 0.2098,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,apoptosis_necroptosis_contribution_score_proxy,float,44,44,0.4434 | 0.3306 | 0.3244,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,z_vad_nec1_disulfide_rescue_flag,integer,44,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,SLC7A11_expression_response,categorical,44,3,IFN_alpha_upregulated_context | not_modeled | IFN_alpha_upregulated_but_knockdown_did_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,SLC7A11_knockdown_aggravation_score_proxy,float,44,44,0.3298 | 0.236 | 0.2918,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,B2M_upregulation_score_proxy,float,44,43,0.4092 | 0.4653 | 0.3845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,USP18_upregulation_score_proxy,float,44,43,0.3303 | 0.3254 | 0.2616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,PSME1_upregulation_score_proxy,float,44,43,0.3151 | 0.5025 | 0.5037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,PSME1_protein_upregulation_flag,integer,44,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,disulfidptosis_relevance_modifier,float,44,44,0.7022 | 0.7959 | 0.7734,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,direct_oligotox_relevance_modifier,float,44,2,0.3 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,context_confidence_score,float,44,2,0.82 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,value_origin,categorical,44,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,assumption_id,categorical,44,1,ASM_033,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ifna_disulfidptosis_hcc_context.csv,record_origin,categorical,44,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,oligo_id,identifier,33,33,OLIGO_0000041 | OLIGO_0000048 | OLIGO_0000053,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,control_id,categorical,33,3,NON_CONTROL_GENERATED_RECORD | CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPO | CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALW,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,source_id,categorical,33,11,BOSCO_INCLISIRAN_FH_REALWORLD_2025 | ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022 | HJELMGREN_PS_ASO_DDR_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,target_gene,categorical,33,15,PSMD9 | PCSK9 | RUBICON,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,modality,categorical,33,14,GalNAc-LNA-ASO | high_affinity_gapmer_RNaseH1_toxicity_me | splice-switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,cell_model,categorical,33,9,HepG2 | human_liver_spheroid | MelJuSo_DDR_toxicity_screen,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,inclisiran_realworld_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,inclisiran_clinical_state,categorical,33,4,secondary_prevention_response_context | six_month_inclisiran_FH_lipid_PWV_respon | stable_liver_muscle_enzyme_monitoring,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,familial_hypercholesterolemia_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,heterozygous_FH_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,PCSK9_hepatic_mRNA_silencing_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,LDLR_expression_restoration_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,inclisiran_dose_mg_proxy,integer,33,1,284.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,followup_months_proxy,integer,33,1,6.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,LDL_C_change_pct_proxy,float,33,33,-31.3591 | -31.3394 | -49.9518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,ApoB_change_pct_proxy,float,33,33,-29.8864 | -28.2127 | -30.7554,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,non_HDL_C_change_pct_proxy,float,33,33,-43.7115 | -40.6484 | -38.2947,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,Lp_a_change_pct_proxy,float,33,33,-15.7633 | -17.489 | -16.2495,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,PWV_change_pct_proxy,float,33,33,-17.1142 | -20.5508 | -18.2562,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,LDL_C_target_attainment_probability_proxy,float,33,3,0.231 | 0.41 | 0.59,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,ALT_AST_stability_delta_proxy,float,33,33,0.0814 | 0.0059 | 0.0758,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,CPK_stability_delta_proxy,float,33,33,0.0733 | -0.0202 | 0.021,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,glucose_profile_stable_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,inflammatory_profile_stable_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,delta_LDL_delta_PWV_association_score_proxy,float,33,25,0.7156 | 0.8587 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,direct_hepatotoxicity_signal_modifier,float,33,33,0.1466 | 0.0107 | 0.1365,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,clinical_tolerability_context_score,float,33,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,value_origin,categorical,33,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,assumption_id,categorical,33,1,ASM_035,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+inclisiran_fh_realworld_context.csv,record_origin,categorical,33,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+information_gap_map.csv,gap_addressed,categorical,144,3,"supporting delivery, mechanism, disease, | direct oligo toxicity or liver-safety re | tracked but not used as a full generatio",Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,hepatotoxicity_relevance,string,144,143,governing | supporting_liver_genetics_MASLD_precisio | directly_relevant_clinical_low_DILI_GalN,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,judging_criterion,categorical,144,1,Potential Impact,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,modality_focus,string,144,144,ASO|gapmer|siRNA|GalNAc-siRNA | siRNA|ASO | GalNAc-siRNA|HSD17B13|rapirosiran|MASH|A,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,source_title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,source_year,integer,144,12,2026 | 2025 | 2023,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,triage_tier,categorical,144,3,supporting | direct | deferred,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,use_in_core_dataset,string,144,52,yes | supporting | yes_core_clinical_PK_PD_safety_module,Identification of fields where future experimental data would have highest value.
+information_gap_map.csv,value_origin,categorical,144,1,source_metadata_curated_generated,Identification of fields where future experimental data would have highest value.
+kupffer_biomimetic_sirna_srli.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.88 | 0.91 | 0.49,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,challenge_alignment,categorical,6,1,supports potential impact and delivery r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,delivery_carrier,string,6,4,none | ZIF-8@siRNA | K-EVs@ZIF-8@siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,inflammatory_cytokine_score_proxy,float,6,6,0.82 | 0.86 | 0.46,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,liver_injury_model,string,6,3,LPS | CLP | mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,liver_or_Kupffer_targeting_score_proxy,float,6,6,0.08 | 0.07 | 0.48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,mechanistic_axis,categorical,6,1,BRCC3_NLRP1_inflammasome_pyroptosis_cont,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,modeling_role,string,6,6,injury_positive_context | sepsis_injury_positive_context | siRNA_nanocarrier_effect,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,module_id,categorical,6,1,Kupffer_biomimetic_BRCC3_siRNA_SRLI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,nanoparticle_features,categorical,6,2,ZIF-8_or_no_carrier | K-EV_membrane|ZIF-8|pH_sensitive|siRNA_l,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,notes,categorical,6,1,Generated liver-injury/delivery scenario,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,oligo_modality,categorical,6,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,pyroptosis_inflammasome_score_proxy,float,6,6,0.79 | 0.83 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,scenario_id,string,6,6,LPS_SRLI_untreated | CLP_SRLI_untreated | ZIF8_BRCC3_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,siRNA_target,categorical,6,1,BRCC3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,source_id,categorical,6,1,MA_KUPFFER_BIOMIMETIC_ZIF8_BRCC3_SIRNA_S,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,target_cell_or_compartment,string,6,4,Kupffer_cell_liver | liver_partial_targeting | Kupffer_cell_targeted,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,therapeutic_efficacy_score_proxy,float,6,5,0.1 | 0.5 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+kupffer_biomimetic_sirna_srli.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,assumption_id,categorical,6,1,ASM_108,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,delivery_or_targeting_score_proxy,float,6,6,0.4 | 0.38 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,mechanism_or_specificity_score_proxy,float,6,5,0.92 | 0.88 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,modality_or_platform,string,6,6,human_single_nucleus_omics | transcriptional_regulation | Dicer substrate siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,model_system,string,6,6,MASH_MetALD_activated_HSCs | TGFb_stimulated_human_HSC | human_HSC_MASH_MetALD_donors,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,modeling_role,string,6,6,human_disease_relevant_fibrosis_expressi | activation_associated_TF_regulation_cont | RNAi_antifibrotic_target_perturbation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,module_id,categorical,6,1,LARP6_HSC_fibrosis_dsiRNA_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,primary_effect_score_proxy,float,6,6,0.7 | 0.68 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,scenario_id,string,6,6,human_MASH_MetALD_HSC_LARP6_upregulation | JUNB_driven_LARP6_activation | LARP6_dsiRNA_knockdown_HSC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,source_id,categorical,6,1,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,toxicity_or_safety_signal_proxy,float,6,4,0.22 | 0.2 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+larp6_hsc_fibrosis_dsirna.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,lipid_homeostasis_id,string,1120,1120,LIPID_CTRL_OLIGO_NEG_VEHICLE_MOCK | LIPID_CTRL_OLIGO_NEG_LOW_RISK | LIPID_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,lipid_export_state,categorical,1120,4,baseline | APOB_ASO_inhibition | combined_lipid_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,mipomersen_like_APOB_ASO,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,apob_inhibition_proxy,float,1120,1008,0.05527 | 0.04932 | 0.06285,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,mttp_activity_suppression_proxy,float,1120,1031,0.0899 | 0.11823 | 0.06286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,vldl_apob_secretion_proxy,float,1120,1043,0.91702 | 0.91149 | 0.97793,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,vldl_particle_size_nm_proxy,float,1120,6,0.0 | 75.0 | 160.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,oleate_challenge,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,heat_stress_challenge,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,lipid_export_stress_score,float,1120,1038,0.1837 | 0.04995 | 0.15272,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,lipotoxicity_context_label,categorical,1120,3,low | high | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,context_note,categorical,1120,1,supporting lipid-homeostasis / ApoB-ASO ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_homeostasis.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,oligo_id,identifier,15,15,OLIGO_0000024 | OLIGO_0000045 | OLIGO_0000152,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,control_id,categorical,15,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,source_id,categorical,15,1,KIM_NANP_LIPID_LIVER_TARGETING_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,target_gene,string,15,13,APOB | MKK4 | MYC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,modality,string,15,12,GalNAc-siRNA | ASO_PNA_BROTHERS_duplex | ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,NANP_DNA_origami_platform_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,cholesterol_lipidation_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,ligand_valency_proxy,float,15,15,5.56338 | 6.26571 | 6.24451,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,LDLR_SR_B1_engagement_score_proxy,float,15,15,0.72324 | 0.81454 | 0.81179,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,HepG2_hepatocyte_association_score_proxy,float,15,15,0.70469 | 0.79366 | 0.79097,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,Kupffer_macrophage_J774A1_association_score_proxy,float,15,15,0.53779 | 0.60569 | 0.60364,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,hepatocyte_selectivity_index_proxy,float,15,15,0.48216 | 0.54303 | 0.54119,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,siRNA_delivery_benchmark_score_proxy,float,15,15,0.50998 | 0.57436 | 0.57241,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,direct_oligotox_relevance,categorical,15,1,supporting_delivery_cell_type_targeting_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,value_origin,categorical,15,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,assumption_id,categorical,15,1,ASM_047,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lipid_nanp_liver_cell_targeting.csv,hash_proxy,float,15,15,0.04189 | 0.81118 | 0.78546,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,assumption_id,categorical,35,1,ASM_063,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,backbone_class,categorical,35,7,standard_PS_LNA | butyl_LNA_PTTE | hexyl_LNA_PTTE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,cell_toxicity_liability_proxy,float,35,35,0.52083 | 0.50398 | 0.49304,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,challenge_gap_addressed,categorical,35,1,expanded_backbone_chemistry_design_space,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,concentration_uM_proxy,float,35,5,0.5 | 1.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,conjugate_class,categorical,35,4,none_or_alkyl | amino_acid | carbohydrate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,contains_LNA,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,contains_phosphothiotriester,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,duplex_stability_score_proxy,float,35,35,0.6195 | 0.65816 | 0.59954,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,estimated_backbone_charge_fraction_proxy,float,35,6,1.0 | 0.45 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,gymnotic_uptake_activity_proxy,float,35,35,0.06239 | 0.10524 | 0.29586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,judging_alignment,categorical,35,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,modality,categorical,35,1,splice_switching_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,modeling_value,categorical,35,1,"supports backbone charge, PS reduction/r",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,module_record_id,string,35,35,supplemental_PTTE_standard_PS_LNA_0p5uM | supplemental_PTTE_standard_PS_LNA_1uM | supplemental_PTTE_standard_PS_LNA_5uM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,predicted_PS_related_protein_binding_liability_proxy,float,35,35,0.67925 | 0.6267 | 0.66385,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,source_id,categorical,35,1,DHARA_LNA_PHOSPHOTHIOTRIESTER_SSO_CLICK_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,source_role,categorical,35,1,supporting_backbone_chemistry_bioactivit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,splice_switching_activity_proxy,float,35,35,0.11214 | 0.13619 | 0.38301,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lna_phosphothiotriester_splice_switching.csv,value_origin,categorical,35,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,arm,categorical,20,5,PBS_control | LNP_CRISPR_negative_sgRNA | LNP_CRISPR_mHao1_low_dose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,assumption_id,categorical,20,1,ASM_060,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,challenge_gap_addressed,categorical,20,1,long_duration_liver_targeted_nucleic_aci,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,disease_context,categorical,20,1,primary_hyperoxaluria_type_1_PH1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,dose_mg_per_kg_proxy,float,20,3,0.0 | 0.3 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,followup_day,integer,20,4,14 | 90 | 180,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,glycolate_oxidase_expression_reduction_proxy,float,20,16,0.0 | 0.05934 | 0.00466,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,immune_response_signal_proxy,float,20,20,0.02296 | 0.03147 | 0.04495,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,judging_alignment,categorical,20,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,kidney_crystal_burden_proxy,float,20,20,0.81597 | 0.88407 | 0.839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,liver_editing_efficiency_fraction_proxy,float,20,15,0.0 | 0.01921 | 0.00378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,liver_toxicity_signal_proxy,float,20,20,0.02274 | 0.03804 | 0.05959,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,modality,categorical,20,1,LNP_CRISPR_Cas9_sgRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,modeling_value,categorical,20,1,supports liver-targeted nucleic-acid del,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,module_record_id,string,20,20,supplemental_PH1_PBS_control_14d | supplemental_PH1_PBS_control_90d | supplemental_PH1_PBS_control_180d,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,predicted_offtarget_indel_signal_proxy,float,20,20,0.01274 | 0.02921 | 0.00654,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,route,categorical,20,1,intravenous_LNP,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,safety_specificity_score_proxy,float,20,20,0.9781 | 0.97016 | 0.95848,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,single_administration_durability_score_proxy,float,20,5,0.0 | 0.949 | 0.94377,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,source_id,categorical,20,1,JIANG_LNP_CRISPR_HAO1_PH1_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,source_role,categorical,20,1,supporting_liver_targeted_nucleic_acid_d,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,target_gene,categorical,20,1,HAO1/Hao1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,urinary_oxalate_burden_proxy,float,20,20,1.17734 | 1.19801 | 1.18831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+lnp_crispr_hao1_ph1_safety.csv,value_origin,categorical,20,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_state,categorical,1120,5,not_modeled | HBx_MALAT1_IGF2BP3_oncogenic_HCC_state | ASO_MALAT1_HBV_HCC_tumor_suppression,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_context_type,categorical,1120,2,not_applicable | HBV_HBx_HCC_ASO_lncRNA_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbx_expression_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_related_hcc_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_expression_score_proxy,float,1120,12,0.0 | 0.84966 | 0.2903,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_poor_prognosis_score_proxy,float,1120,12,0.0 | 0.67882 | 0.36763,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_m6a_score_proxy,float,1120,12,0.0 | 0.67957 | 0.34899,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_mettl3_mettl14_wtap_recruitment_score_proxy,float,1120,12,0.0 | 0.80646 | 0.3334,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_m6a_site_6021A_score_proxy,float,1120,12,0.0 | 0.67229 | 0.32344,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_m6a_site_7265A_score_proxy,float,1120,12,0.0 | 0.66001 | 0.40102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_expression_score_proxy,float,1120,12,0.0 | 0.71822 | 0.46274,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_binding_score_proxy,float,1120,12,0.0 | 0.69879 | 0.48949,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_kh3_domain_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_cytoplasmic_export_score_proxy,float,1120,12,0.0 | 0.57292 | 0.53929,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_rna_stability_half_life_hours_proxy,float,1120,12,0.0 | 17.48589 | 14.68476,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_aso_treatment_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_aso_tumor_suppression_score_proxy,float,1120,11,0.0 | 0.15652 | 0.92421,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_xenograft_suppression_score_proxy,float,1120,12,0.0 | 0.20369 | 0.98247,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_orthotopic_liver_tumor_suppression_score_proxy,float,1120,12,0.0 | 0.25531 | 0.93951,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_pgRNA_reduction_proxy,float,1120,10,0.0 | 0.1154 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_DNA_reduction_proxy,float,1120,11,0.0 | 0.40731 | 0.05191,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_emtscore_vimentin_proxy,float,1120,12,0.0 | 0.67226 | 0.41068,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_e_cadherin_recovery_score_proxy,float,1120,12,0.0 | 0.55824 | 0.90905,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hepatocarcinogenesis_context_modifier,float,1120,11,0.0 | 0.65181 | 0.59177,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_direct_oligotox_relevance_modifier,float,1120,12,0.0 | 0.11954 | 0.15288,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_context_confidence_score,float,1120,12,0.0 | 0.86844 | 0.90746,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,context_note,categorical,1120,3,Supporting MALAT1/HBV/HCC ASO context | Supporting HBV/HBx-related HCC ASO-MALAT | No MALAT1/HBV/HCC ASO context modeled fo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+malat1_hbv_hcc_aso_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_cirrhosis_state,categorical,1120,4,not_modeled | high_risk_cirrhosis_post_discharge_morta | low_risk_cirrhosis_post_discharge_mortal,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_context_type,categorical,1120,3,not_modeled | clinical_cirrhosis_mortality_risk_contex | not_applicable,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_cirrhosis_related_admission_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_uses_emr_structured_variables_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_variable_count_proxy,integer,1120,2,0.0 | 9.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_meld_na_component_count_proxy,integer,1120,2,0.0 | 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_albumin_g_dl_proxy,float,1120,11,0.0 | 2.54349 | 3.39428,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_total_bilirubin_mg_dl_proxy,float,1120,11,0.0 | 5.19518 | 0.87482,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_creatinine_mg_dl_proxy,float,1120,11,0.0 | 1.75739 | 0.76745,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_inr_proxy,float,1120,11,0.0 | 1.84089 | 0.96113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_sodium_mmol_l_proxy,float,1120,11,0.0 | 136.42915 | 138.82276,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_wbc_th_cumm_proxy,float,1120,11,0.0 | 10.54493 | 3.07463,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_total_cholesterol_mg_dl_proxy,float,1120,11,0.0 | 94.15689 | 144.8127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_age_years_proxy,float,1120,11,0.0 | 74.73189 | 45.84616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_length_of_stay_days_proxy,float,1120,11,0.0 | 13.30606 | 1.92592,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_predicted_90day_mortality_probability_proxy,float,1120,11,0.0 | 0.31151 | 0.10331,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_risk_quintile_proxy,categorical,1120,5,not_modeled | Q1_highest_risk | Q4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_observed_predicted_alignment_score_proxy,float,1120,11,0.0 | 0.94965 | 0.97391,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_auroc_mgh_bwh_90day_proxy,float,1120,2,0.0 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_auroc_meldna_90day_proxy,float,1120,2,0.0 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_auroc_mgh_bwh_approx_1yr_proxy,float,1120,2,0.0 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_auroc_external_validation_proxy,float,1120,2,0.0 | 0.69,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_improvement_over_meldna_90day_pct_proxy,float,1120,2,0.0 | 11.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_improvement_over_meldna_external_pct_proxy,float,1120,2,0.0 | 16.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_clinical_severity_modifier,float,1120,11,0.0 | 0.48347 | 0.28593,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_direct_oligotox_relevance_modifier,float,1120,11,0.0 | 0.08716 | 0.09268,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,meldplus_context_confidence_score,float,1120,11,0.0 | 0.72202 | 0.83528,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,context_note,categorical,1120,3,Supporting MELD-Plus clinical liver-risk | Supporting clinical cirrhosis severity/o | No MELD-Plus/cirrhosis clinical-risk con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+meldplus_cirrhosis_risk_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+model_readiness_report.csv,include_in_baseline_model,string,31,20,yes | yes_label | validation_only,Modeling-readiness summary across required predictor and outcome fields.
+model_readiness_report.csv,modeling_role,string,31,24,primary_entity_table | predictor_table | assay_context_table,Modeling-readiness summary across required predictor and outcome fields.
+model_readiness_report.csv,recommended_use,string,31,26,"oligo-level features, IDs, modality, tar | PS burden, sugar chemistry, backbone, li | GC, Tm, off-target and sequence-derived ",Modeling-readiness summary across required predictor and outcome fields.
+model_readiness_report.csv,table_name,string,31,31,oligos.csv | chemical_modifications.csv | biophysical_properties.csv,Modeling-readiness summary across required predictor and outcome fields.
+mptp_oxmtdna_mash_pyroptosis.csv,ALT_AST_liver_injury_score_proxy,float,5,4,0.78 | 0.34 | 0.73,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,NLRP3_activation_score_proxy,float,5,5,0.84 | 0.38 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,assumption_id,categorical,5,1,ASM_084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,cell_context,string,5,3,macrophage | THP1_derived_macrophage | liver_macrophage,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,challenge_alignment,categorical,5,1,supports mechanistic liver-injury modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,condition_or_intervention,string,5,5,MCD_diet | MCD_plus_CsA | free_fatty_acid_in_vitro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,cytosolic_ox_mtdna_context,categorical,5,2,high | reduced,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,fibrosis_or_progression_context_score_proxy,float,5,5,0.74 | 0.3 | 0.66,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,macrophage_pyroptosis_score_proxy,float,5,5,0.82 | 0.35 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,modeling_role,string,5,5,disease_context_positive | mechanism_rescue_control | in_vitro_stress_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,module_id,categorical,5,1,mptp_oxmtdna_mash_pyroptosis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,notes,categorical,5,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,overall_MASH_injury_score_proxy,float,5,5,0.8 | 0.32 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,scenario_id,string,5,5,MCD_MASH_baseline | MCD_CsA_mPTP_inhibition | FFA_THP1_macrophage_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,siRNA_or_gene_silencing_context,categorical,5,2,no | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,source_id,categorical,5,1,ZHANG_MPTP_OXMTDNA_MASH_ITPR3_NLRP3_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+mptp_oxmtdna_mash_pyroptosis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,oligo_id,identifier,4,4,OLIGO_0000174 | OLIGO_0000346 | OLIGO_0000579,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,control_id,categorical,4,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,source_id,categorical,4,1,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,target_gene,string,4,4,ALK4 | APOB | ERBB2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,modality,string,4,3,siRNA | GalNAc-LNA-ASO | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,heteroduplex_ASO_RNA_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,folate_ligand_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,peptide_ligand_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,dual_functionalization_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,intracellular_delivery_score_proxy,float,4,4,0.75649 | 0.79247 | 0.67222,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,GFP_fluorescence_reduction_pct_proxy,integer,4,1,5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,BCL2_knockdown_score_proxy,float,4,4,0.69677 | 0.72991 | 0.61915,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,offtarget_toxicity_design_attention_score_proxy,float,4,4,0.54746 | 0.5735 | 0.48647,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,non_liver_delivery_gap_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,challenge_gap_addressed,categorical,4,1,delivery_design_context_for_non_liver_ol,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,direct_oligotox_relevance,categorical,4,1,supporting_delivery_design_context_not_l,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,value_origin,categorical,4,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,assumption_id,categorical,4,1,ASM_050,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,hash_proxy,float,4,4,0.47856 | 0.70699 | 0.01657,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+multifunctional_hdo_delivery.csv,hash_proxy_2,float,4,4,0.72506 | 0.22451 | 0.85407,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,oligo_id,identifier,10,10,OLIGO_0000342 | OLIGO_0000389 | OLIGO_0000396,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,control_id,categorical,10,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,source_id,categorical,10,1,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,target_gene,string,10,9,DDR_repair_enzyme_binding_context | ANGPTL8 | PAPD7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,modality,string,10,9,gapmer | GalNAc-LNA-ASO | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,asymmetric_siRNA_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,docosanoic_acid_conjugation_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,vinylphosphonate_modification_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,reduced_passenger_seed_offtarget_score_proxy,float,10,10,0.75647 | 0.80167 | 0.81737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,nuclease_resistance_score_proxy,float,10,10,0.77638 | 0.82276 | 0.83888,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,durable_knockdown_days_proxy,integer,10,1,5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,MYC_knockdown_score_proxy,float,10,10,0.73656 | 0.78057 | 0.79586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,RRM2_RAD51_PARP1_downstream_suppression_proxy,float,10,10,0.6868 | 0.72783 | 0.74209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,visible_toxicity_absence_score_proxy,float,10,10,0.8361 | 0.88605 | 0.90341,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,extrahepatic_delivery_context_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,challenge_gap_addressed,categorical,10,1,siRNA_design_offtarget_reduction_and_dur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,direct_oligotox_relevance,categorical,10,1,supporting_modification_delivery_safety_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,value_origin,categorical,10,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,assumption_id,categorical,10,1,ASM_049,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,hash_proxy,float,10,10,0.47843 | 0.76839 | 0.87602,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+myc_asirna_dca_design_safety.csv,hash_proxy_2,float,10,10,0.25753 | 0.776 | 0.60876,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_id,string,1120,1120,DELIV_CTRL_OLIGO_NEG_VEHICLE_MOCK | DELIV_CTRL_OLIGO_NEG_LOW_RISK | DELIV_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_carrier_type,categorical,1120,20,cholesterol_conjugate | no_nanocarrier | PLGA_nanoparticle,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_carrier_class,categorical,1120,7,none | polymeric | direct_ligand_conjugate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,nanoparticle_size_nm,float,1120,407,0.0 | 122.66673 | 85.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,zeta_potential_mV,float,1120,412,0.0 | -0.33049 | -8.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,pegylated,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,targeting_ligand,categorical,1120,7,none | GalNAc | galactose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,targeting_receptor,categorical,1120,5,none | ASGPR | mannose_receptor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,encapsulation_efficiency,float,1120,394,0.0 | 0.79382 | 0.90757,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,release_half_life_hours,float,1120,411,0.0 | 81.86958 | 14.03248,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,hepatic_targeting_score,float,1120,871,0.41749 | 0.28 | 0.96697,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,kupffer_clearance_risk,float,1120,883,0.03097 | 0.08 | 0.16635,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_immunogenicity_score,float,1120,878,0.08285 | 0.08 | 0.17857,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_oxidative_stress_score,float,1120,803,0.06177 | 0.03 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,delivery_toxicity_modifier,float,1120,895,-0.02771 | 0.0515 | -0.16845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nanoparticle_delivery.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,assumption_id,categorical,7,1,ASM_128,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,key_model_selection_consideration,string,7,7,gene_isoform_expression_check | genome_context_and_variant_specificity | unassisted_cellular_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,model_type,string,7,7,immortalized_or_relevant_cell_line | patient_cells | in_vitro_delivery_condition,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,model_validity_score_proxy,float,7,7,0.74 | 0.82 | 0.68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,module_id,categorical,7,1,preclinical_model_selection_for_NATs,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,notes,string,7,7,useful_for_screening_but_target_isoform_ | better_variant_specificity_and_individua | may_better_reflect_in_vivo_activity_than,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,scenario_id,string,7,7,endogenous_target_cell_line_screen | patient_derived_cell_model | free_uptake_gymnosis_assay,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,source_id,categorical,7,1,OLIVER_HILL_MODEL_SELECTION_NAT_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,toxicity_interpretation_complexity_score_proxy,float,7,6,0.58 | 0.5 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,translation_relevance_score_proxy,float,7,6,0.6 | 0.72 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nat_model_selection_evidence.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.7 | 0.78 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,NG2_CSPG4_expression_score_proxy,float,6,5,0.78 | 0.85 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,assumption_id,categorical,6,1,ASM_085,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,challenge_alignment,categorical,6,1,supports direct liver fibrosis and injur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,collagen_fibrosis_score_proxy,float,6,6,0.74 | 0.82 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,intervention_or_observation,categorical,6,2,observational | Cspg4_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,model_system,string,6,5,human_fibrotic_liver | MCDHF_mouse_liver | CCl4_mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,modeling_role,string,6,6,human_context | disease_model_positive | orthogonal_fibrosis_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,module_id,categorical,6,1,ng2_cspg4_sirna_liver_fibrosis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,myofibroblast_activation_score_proxy,float,6,6,0.8 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,scenario_id,string,6,6,human_fibrotic_liver_CSPG4_high | MCDHF_fibrosis_NG2_high | CCl4_fibrosis_NG2_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,siRNA_context,categorical,6,2,no | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,source_id,categorical,6,1,YANG_NG2_CSPG4_SIRNA_LIVER_FIBROSIS_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,steatosis_inflammation_score_proxy,float,6,6,0.66 | 0.76 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ng2_cspg4_sirna_liver_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,assumption_id,categorical,5,1,ASM_099,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,challenge_alignment,categorical,5,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,delivery_or_targeting_score_proxy,float,5,5,0.45 | 0.7 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,immune_or_cell_state_score_proxy,float,5,5,0.82 | 0.2 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,modality_or_platform,string,5,4,systemic_ASO | tissue_selective_siRNA | genetic_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,model_system,string,5,5,APOE_Leiden_CETP_mouse | liver_adipose | lesional_macrophage_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,modeling_role,string,5,5,systemic_ASO_disease_modification | limited_effect_compartment_contrast | macrophage_compartment_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,module_id,categorical,5,1,NNMT_ASO_macrophage_immunometabolism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,notes,categorical,5,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,primary_effect_score_proxy,float,5,5,0.9 | 0.72 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,scenario_id,string,5,5,global_NNMT_ASO_hyperlipidemic_mice | liver_adipose_selective_NNMT_siRNA | Nnmt_KO_bone_marrow_transplant,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,source_id,categorical,5,1,SINHA_NNMT_ASO_MACROPHAGE_ATHEROSCLEROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,toxicity_or_safety_signal_proxy,float,5,4,0.22 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+nnmt_aso_macrophage_atherosclerosis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_lsec_state,categorical,1120,6,not_modeled | lipotoxic_hepatocyte_sEV_OGT_high | OGT_knockdown_sEV_reduced_capillarizatio,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_context_type,categorical,1120,2,not_applicable | supporting_MASLD_liver_microenvironment_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_lth_sev_dose_ug_ml_proxy,integer,1120,3,0.0 | 400.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_diameter_nm_proxy,float,1120,19,0.0 | 108.34859 | 92.75209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_liver_enrichment_score_proxy,float,1120,19,0.0 | 0.69218 | 0.88031,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_lsec_endocytosis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_ogt_cargo_score_proxy,float,1120,19,0.0 | 0.76398 | 0.13827,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_oga_change_score_proxy,float,1120,19,0.0 | 0.11032 | 0.01978,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_total_OGlcNAcylation_score_proxy,float,1120,17,0.0 | 0.82633 | 0.18459,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_HNF1A_ser471_OGlcNAcylation_score_proxy,float,1120,17,0.0 | 0.895 | 0.30292,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_HNF1A_nuclear_translocation_score_proxy,float,1120,19,0.0 | 0.73057 | 0.4005,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_Ang2_transcription_activation_score_proxy,float,1120,18,0.0 | 0.80701 | 0.19478,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_Ang2_serum_proxy_ng_ml_scaled,float,1120,19,0.0 | 498.00832 | 271.45422,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_LSEC_capillarization_score_proxy,float,1120,17,0.0 | 0.66364 | 0.13266,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_LSEC_defenestration_score_proxy,float,1120,19,0.0 | 0.61904 | 0.13405,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_CD31_vascularization_score_proxy,float,1120,19,0.0 | 0.69137 | 0.28806,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_alpha_SMA_activation_score_proxy,float,1120,17,0.0 | 0.70076 | 0.28217,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_collagen_deposition_score_proxy,float,1120,17,0.0 | 0.75936 | 0.26649,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_ALT_AST_correlation_context_score_proxy,float,1120,18,0.0 | 0.72069 | 0.39102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_TG_correlation_context_score_proxy,float,1120,19,0.0 | 0.6132 | 0.3317,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_inflammation_IL1B_IL6_TNFA_score_proxy,float,1120,17,0.0 | 0.80429 | 0.25831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_serum_OGT_AUC_proxy,float,1120,2,0.0 | 0.6832,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_serum_sEV_OGT_AUC_proxy,float,1120,2,0.0 | 0.7278,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_OGT_knockdown_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_dose_mg_proxy,float,1120,3,0.0 | 1.0 | 0.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_rescue_score_proxy,float,1120,3,0.0 | 0.35868 | 0.23267,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_masld_progression_modifier,float,1120,19,0.0 | 0.75195 | 0.26113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_direct_oligotox_relevance_modifier,float,1120,19,0.0 | 0.09023 | 0.03134,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,ogt_sev_context_confidence_score,float,1120,19,0.0 | 0.966 | 0.83841,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,context_note,categorical,1120,3,No OGT/sEV/LSEC/MASLD context modeled fo | Supporting MASLD/LSEC extracellular-vesi | Supporting OGT/sEV/LSEC/MASLD context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ogt_sev_lsec_masld_context.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oligo_modification_positions.csv,oligo_id,string,24147,1089,CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE | CTRL_OLIGO_NEG_SPHEROID_TOLERATED,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,strand,categorical,24147,2,antisense | single,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,position,integer,24147,30,1 | 2 | 3,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,base,categorical,24147,5,A | U | C,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,sugar_modification,string,24147,40,2-prime-O-methyl | 2-prime-fluoro | 2-prime-MOE,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,backbone_3prime_linkage,categorical,24147,2,phosphorothioate | phosphodiester,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,region,categorical,24147,9,5_prime_terminal | seed_region | central,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,terminal_conjugate,categorical,24147,2,none | GalNAc_3prime,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,modification_provenance,categorical,24147,1,literature_grounded_generated,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligo_modification_positions.csv,source_id,string,24147,81,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
+oligos.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,sequence_5to3,string,1105,1066,AUAUCUAUAUCUAUAUCUAUA | GCUAUGAACUUGACUCUAUGA | UUCGAUAGGCCACGAGAUUAU,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,sequence_length,integer,1120,19,0 | 21 | 19,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,sequence_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,control_type,string,1120,114,negative_control_vehicle_mock | negative_control_low_risk_oligo | clinical_low_hepatotoxicity_reference,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,record_origin,categorical,1120,1,dbbun_generated,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,confidence_level,float,1120,936,0.88 | 0.9 | 0.82,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oligos.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
+oral_mir29a_liver_fibrosis_na.csv,alt_fold_baseline_proxy,float,120,120,3.81933 | 3.97865 | 3.45671,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,col1a1_suppression_fraction_proxy,float,120,104,0.0 | 0.01623 | 0.01699,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,collagen_deposition_score_proxy,float,120,120,0.96914 | 0.82144 | 0.94073,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,delivery_system,categorical,120,1,none_no_DDS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,disease_context,categorical,120,2,CCl4_chronic_liver_fibrosis | in_vitro_target_suppression_screen,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,fibrosis_improvement_score_proxy,float,120,111,0.0 | 0.12487 | 0.15643,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,gi_tract_detection_score_proxy,float,120,116,0.02045 | 0.03524 | 0.01791,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,judging_alignment,categorical,120,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,liver_detection_score_proxy,float,120,109,0.04451 | 0.00787 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,modeling_value,categorical,120,1,supporting_liver_delivery_fibrosis_modif,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,modified_na_tolerability_score_proxy,float,120,120,0.77212 | 0.75704 | 0.73143,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,module_record_id,string,120,120,MIR29A_FIB_0001 | MIR29A_FIB_0002 | MIR29A_FIB_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,nuclease_resistant_design,categorical,120,1,RNA_DNA_hybrid_LNA_PS_2primeF_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,pdgfc_suppression_fraction_proxy,float,120,109,0.08084 | 0.0 | 0.04634,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,route,categorical,120,2,oral | cell_transfection_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,source_id,categorical,120,1,UMEZU_ORAL_MIR29A_LIVER_FIBROSIS_NA_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,treatment_arm,categorical,120,5,CCl4_only | oral_seed_miR29a_like_modified_NA | oral_COL1A1_targeting_RNA_DNA_hybrid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,value_origin,categorical,120,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+oral_mir29a_liver_fibrosis_na.csv,week_context,integer,120,4,1 | 2 | 5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,oligo_id,identifier,35,35,OLIGO_0000075 | OLIGO_0000093 | OLIGO_0000183,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,control_id,categorical,35,6,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBL | CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,source_id,categorical,35,1,KANDA_PCDHA11_AMNA_ASO_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,target_gene,categorical,35,1,PCDHA11,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,modality,categorical,35,1,AmNA-modified_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,cell_model,unknown,0,0,,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,pcdha11_amna_state,categorical,35,6,lower_liver_signal_2255_like_reversible_ | lower_offtarget_3319_like_reversible_con | high_sequence_dependent_reversible_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,pcdha11_candidate_proxy,categorical,35,6,hPCDHA11_2255_like | hPCDHA11_3319_like | hPCDHA11_3969_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,AmNA_modified_flanking_nucleotide_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,all_phosphate_groups_phosphorothioated_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,intraperitoneal_weekly_mouse_toxicology_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,in_vitro_transfection_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,in_vitro_transfection_nM_proxy,integer,35,3,400.0 | 25.0 | 100.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,mouse_intraperitoneal_dose_mg_proxy,float,35,3,0.2 | 0.6 | 2.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,mouse_dose_tier,categorical,35,3,0.2_mg_low | 0.6_mg_mid | 2.0_mg_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,weekly_administration_weeks_proxy,integer,35,1,4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,post_cessation_recovery_weeks_proxy,integer,35,1,3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,PCDHA11_knockdown_efficacy_score_proxy,float,35,34,0.8708 | 0.4714 | 0.8584,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,tumor_growth_inhibition_score_proxy,float,35,35,0.6792 | 0.4123 | 0.6593,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,apoptosis_caspase_activation_score_proxy,float,35,34,0.5989 | 0.3792 | 0.5921,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,migration_invasion_spheroid_stemness_inhibition_score_proxy,float,35,34,0.6851 | 0.4534 | 0.6779,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,AST_peak_fold_proxy,float,35,35,4.3409 | 4.7041 | 4.9328,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,ALT_peak_fold_proxy,float,35,35,3.9666 | 4.2898 | 4.4916,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,ALP_peak_fold_proxy,float,35,22,2.0834 | 2.3169 | 2.4294,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,total_bilirubin_fold_proxy,integer,35,1,1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,bilirubin_elevation_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,renal_dysfunction_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,creatinine_fold_proxy,float,35,35,1.0266 | 1.0104 | 1.0219,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,urea_nitrogen_fold_proxy,float,35,35,1.0266 | 1.0104 | 1.0219,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,amylase_fold_proxy,float,35,34,1.023 | 1.0108 | 1.016,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,body_weight_ratio_end_to_baseline_proxy,float,35,28,1.0028 | 0.9999 | 1.0017,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,gross_skin_injection_site_signal_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,organ_histology_major_change_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,recovery_after_treatment_cessation_score_proxy,float,35,17,0.88 | 0.84 | 0.62,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,reversibility_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,sequence_dependent_liver_injury_score_proxy,float,35,18,0.32 | 0.38 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,dose_dependent_liver_injury_score_proxy,float,35,3,0.1 | 0.3 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,offtarget_mismatch_burden_proxy,integer,35,6,10 | 16 | 47,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,microarray_offtarget_perturbation_score_proxy,float,35,32,0.4563 | 0.5631 | 0.57,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,GGGenome_like_mismatch_screening_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,microarray_validation_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,PCDHA11_knockout_specificity_context_flag,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,normal_Pcdha11_deficient_mouse_context_flag,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,overall_pcdha11_amna_hepatotoxicity_score_proxy,float,35,35,3.0326 | 3.3525 | 3.4787,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,direct_oligotox_hepatotoxicity_relevance,categorical,35,1,direct_preclinical_oligo_hepatotoxicity_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,phase2_alignment,categorical,35,1,direct_liver_readouts_controls_dose_sequ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,value_origin,categorical,35,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcdha11_amna_aso_hepatotoxicity.csv,assumption_id,categorical,35,1,ASM_042,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,assumption_id,categorical,6,1,ASM_114,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,delivery_or_targeting_score_proxy,float,6,6,0.7 | 0.66 | 0.44,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,modality_or_platform,string,6,6,PCSK9-siRNA_plus_STING_agonist | siRNA_immunomodulation | cellular_trafficking_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,model_system,string,6,6,BMDC_and_monocyte_reporter_models | STING_KO_validation_context | COPII_STING_anterograde_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,modeling_role,string,6,6,siRNA_modulation_of_innate_immune_pathwa | mechanistic_specificity_validation | subcellular_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,module_id,categorical,6,1,PCSK9_siRNA_STING_hepatic_immune_toxicit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,primary_effect_score_proxy,float,6,6,0.84 | 0.82 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,scenario_id,string,6,6,PCSK9_siRNA_STING_signal_amplification | STING_dependent_IFN_response | SURF4_STING_PCSK9_trafficking,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,source_id,categorical,6,1,SUN_PCSK9_SIRNA_STING_CANCER_IMMUNOTHERA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,toxicity_or_safety_signal_proxy,float,6,5,0.3 | 0.32 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pcsk9_sirna_sting_cancer_immunotherapy.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,assumption_id,categorical,6,1,ASM_117,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,delivery_or_targeting_score_proxy,float,6,4,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,mechanism_or_specificity_score_proxy,float,6,6,0.84 | 0.86 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,modality_or_platform,string,6,3,aptamer-siRNA_chimera | siRNA_gene_silencing | aptamer-siRNA_immunotherapy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,model_system,string,6,6,PDL1_CD47_dual_targeting_design | Hepa1_6_HCC_tumor_infiltrating_Tregs | tumor_associated_Treg_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,modeling_role,string,6,6,selective_RNA_payload_design_context | cell_selective_delivery_context | RNAi_target_knockdown_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,module_id,categorical,6,1,PDL1_aptamer_CD47_siRNA_Treg_HCC_module,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.82 | 0.84,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,scenario_id,string,6,6,PDL1_aptamer_CD47_siRNA_design | intratumoral_Treg_selective_binding | CD47_knockdown_Treg_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,source_id,categorical,6,1,ZENG_PDL1_APTAMER_CD47_SIRNA_TREG_HCC_20,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,toxicity_or_safety_signal_proxy,float,6,5,0.24 | 0.2 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pdl1_aptamer_cd47_sirna_treg_hcc.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,personalized_aso_id,string,1120,1120,PASO_CTRL_OLIGO_NEG_VEHICLE_MOCK | PASO_CTRL_OLIGO_NEG_LOW_RISK | PASO_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,personalized_aso_state,categorical,1120,6,baseline_not_personalized | n_of_1_clinical_monitoring | rat_intrathecal_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,customized_to_patient_variant,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,splice_modulating_strategy,categorical,1120,3,not_personalized_context | cryptic_splice_acceptor_blocking | splice_enhancer_masking,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,cryptic_splice_site_targeted,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,aso_length_nt_proxy,integer,1120,7,0 | 22 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,aso_backbone_chemistry,categorical,1120,2,not_applicable | phosphorothioate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,aso_sugar_chemistry,categorical,1120,4,not_applicable | 2prime_MOE | 2prime_OMe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,sequence_specific_offtarget_screen_pass,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,fibroblast_splice_rescue_fold_proxy,float,1120,25,0.0 | 3.0 | 2.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,normal_splicing_fraction_proxy,float,1120,25,0.0 | 0.34 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,functional_cell_rescue_score_proxy,float,1120,25,0.0 | 0.7 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,intrathecal_route_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,cns_targeting_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,rat_toxicology_dose_multiple_proxy,float,1120,4,0.0 | 2.5 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,transient_neurotoxicity_signal_proxy,float,1120,7,0.0 | 0.35 | 0.60793,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,human_dose_mg_proxy,integer,1120,6,0.0 | 42.0 | 35.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,dose_escalation_schedule_proxy,categorical,1120,4,not_applicable | escalating_loading_then_quarterly_mainte | preclinical_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,csf_trough_ng_per_ml_proxy,float,1120,11,0.0 | 22.0 | 21.64432,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,systemic_exposure_context_label,categorical,1120,3,not_applicable | limited_systemic_exposure | not_clinical_dosing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,personalized_workflow_confidence_score,float,1120,26,0.0 | 0.72 | 0.712,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,context_note,categorical,1120,2,patient-customized ASO design/safety wor | patient-customized ASO workflow context;,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+personalized_aso_workflow.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,oligo_id,identifier,17,17,OLIGO_0000023 | OLIGO_0000307 | OLIGO_0000458,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,source_id,categorical,17,1,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,control_id,categorical,17,4,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_ | CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,target_gene,categorical,17,7,DGAT2 | PCSK9 | PNPLA3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,oligo_modality,categorical,17,1,engineered_sEV_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,pmevl_state,categorical,17,3,PMEVL_sEV_siPcsk9_hepatic_delivery_safe | PMEVL_N_myristoylation_small_RNA_loading | not_primary_PMEVL_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,pmevl_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,engineered_sEV_delivery_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,N_myristoylation_peptide_loading_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,myr_peptide_class_proxy,categorical,17,1,CHMP6_or_optimized_Myr_peptide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,RNA_cargo_class,categorical,17,3,siPcsk9 | multi_RNA_loading_context | not_applicable,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,PMEVL_target_gene_context,categorical,17,5,PCSK9 | APOC3 | DGAT2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,pri_miR30a_siRNA_scaffold_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,multi_siRNA_coloading_context_flag,integer,17,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,protein_RNA_coloading_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,sEV_size_nm_proxy,integer,17,1,134.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,sEV_particles_per_cell_proxy,integer,17,1,260.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,siRNA_loading_fold_enrichment_proxy,integer,17,4,410.0 | 60.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,miRNA_loading_fold_enrichment_proxy,integer,17,4,15.0 | 60.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,mRNA_loading_fold_enrichment_proxy,integer,17,1,278.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,ANXA2_RNA_sorting_context_score,float,17,1,0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,ALIX_TSG101_ESCRT_sorting_context_score,float,17,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,AGO2_RISC_bridge_context_score,float,17,1,0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,ERK1_2_activation_score_proxy,float,17,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,AMPK_autophagy_inhibition_score_proxy,float,17,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,hepatic_biodistribution_score_proxy,float,17,3,0.86 | 0.35 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,hepatic_Pcsk9_knockdown_fraction_proxy,float,17,3,0.55 | 0.12 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,LDLR_expression_fold_proxy,float,17,3,1.75 | 1.05 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,serum_LDL_C_change_fraction_proxy,float,17,3,-0.28 | -0.04 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,serum_total_cholesterol_change_fraction_proxy,float,17,3,-0.224 | -0.032 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,serum_triglyceride_change_fraction_proxy,integer,17,1,0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,ALT_fold_normalized_proxy,float,17,2,1.02 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,AST_fold_normalized_proxy,float,17,2,1.01 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,major_organ_histology_abnormality_flag,integer,17,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,systemic_toxicity_context_label,categorical,17,3,low_systemic_toxicity_with_hepatic_RNAi_ | RNA_loading_context_no_direct_injury_sig | not_assessed_for_this_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,PMEVL_context_confidence_score,float,17,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,assumption_id,categorical,17,1,ASM_031,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pmevl_sev_rna_loading_pcsk9_context.csv,record_origin,categorical,17,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,assumption_id,categorical,6,1,ASM_126,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,genotype_specificity_score_proxy,float,6,5,0.8 | 0.84 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,model_system,string,6,6,human_precision_genetics | human_primary_hepatocyte_3D_spheroid | human_transgenic_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,module_id,categorical,6,1,PNPLA3_AZD2693_precision_MASH_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,notes,string,6,6,MASH_fibrosis_cirrhosis_HCC_liver_mortal | preclinical_mRNA_protein_knockdown_conte | in_vivo_preclinical_target_engagement_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,pk_pd_interpretability_score_proxy,float,6,5,0.2 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,precision_medicine_context,categorical,6,1,PNPLA3_148M_homozygous_MASH,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,safety_signal_score_proxy,float,6,6,0.58 | 0.34 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,scenario_id,string,6,6,PNPLA3_148M_homozygous_risk_context | AZD2693_3D_hepatocyte_spheroid_target_en | AZD2693_human_PNPLA3_transgenic_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,source_id,categorical,6,1,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,target_engagement_or_response_score_proxy,float,6,6,0.92 | 0.86 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,target_or_endpoint,string,6,6,PNPLA3_p.I148M | PNPLA3_mRNA_protein | PNPLA3_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_azd2693_precision_mash.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_context_id,string,1120,1120,PNPLA3_CTRL_OLIGO_NEG_VEHICLE_MOCK | PNPLA3_CTRL_OLIGO_NEG_LOW_RISK | PNPLA3_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_context_state,categorical,1120,5,baseline_non_PNPLA3 | PNPLA3_I148M_homozygous_lipid_stress | PNPLA3_homozygous_silencing_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_genotype,categorical,1120,4,not_modeled | GG_I148M_homozygous | CG_heterozygous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_i148m_allele_count,integer,1120,3,0 | 2 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_homozygous_I148M,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_environmental_context,categorical,1120,6,not_PNPLA3_context | obesity_high_sugar_diet | overweight_insulin_resistance,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_expression_proxy,float,1120,43,0.0 | 0.72063 | 0.66325,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_lipid_droplet_accumulation_proxy,float,1120,37,0.0 | 1.0 | 0.64742,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_triglyceride_hydrolase_loss_proxy,float,1120,43,0.0 | 0.88758 | 0.97549,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_pnpla2_inhibition_proxy,float,1120,39,0.0 | 0.95 | 0.75077,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_liver_fat_liability_modifier,float,1120,36,0.0 | 1.5025 | 0.99307,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_precision_therapy_modality,categorical,1120,3,none | PNPLA3_siRNA_precision_silencing | PNPLA3_ASO_precision_silencing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_target_knockdown_pct_proxy,float,1120,14,0.0 | 78.0 | 62.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_hepatic_fat_reduction_pct_proxy,float,1120,14,0.0 | 27.15312 | 11.78057,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_inflammation_reduction_proxy,float,1120,14,0.0 | 0.2765 | 0.07657,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_fibrosis_risk_modifier,float,1120,35,0.0 | 0.7212 | 0.31049,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_precision_rescue_modifier,float,1120,14,0.0 | 0.8309 | 0.33663,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,pnpla3_therapy_response_label,categorical,1120,5,baseline_non_PNPLA3_context | high_risk_no_precision_therapy | homozygous_precision_therapy_responder,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,context_note,categorical,1120,2,PNPLA3 precision-genetics and therapy-re | PNPLA3 precision-genetics context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pnpla3_precision_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,RNA_delivery_efficacy_score_proxy,float,6,6,0.32 | 0.9 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,biocompatibility_score_proxy,float,6,4,0.88 | 0.91 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,challenge_alignment,categorical,6,1,"supports delivery realism, toxicity-safe",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,delivery_platform,string,6,5,MC3_standard_LNP | MC3_NS102_pLNP | ALC0315_NS102_pLNP,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,endosomal_escape_score_proxy,float,6,6,0.36 | 0.89 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,factor_VII_siRNA_activity_context,categorical,6,2,not_primary | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,liver_toxicity_liability_score_proxy,float,6,5,0.18 | 0.16 | 0.15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,mRNA_expression_context,categorical,6,2,included | not_primary,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,module_id,categorical,6,1,polyamine_pLNP_RNA_delivery_safety_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,notes,categorical,6,1,Generated delivery-platform row; no sour,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,pH_buffering_score_proxy,float,6,6,0.3 | 0.82 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,payload_type,string,6,4,mRNA | siRNA_FVII | mRNA_or_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,polyamine_component,categorical,6,2,none_or_standard | NS102_low_MW_tertiary_amine,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,primary_delivery_context,string,6,3,liver | systemic_or_intramuscular | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,scenario_id,string,6,6,standard_MC3_LNP_mRNA | NS102_4p5mol_pLNP_mRNA_liver | NS102_pLNP_siFVII_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,scenario_role,string,6,5,standard_lnp_reference | enhanced_liver_mRNA_expression | enhanced_siRNA_activity_lower_ED50,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,source_id,categorical,6,1,KANNAN_POLYAMINE_PLNP_RNA_DELIVERY_SAFET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+polyamine_plnp_rna_delivery_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,oligo_id,identifier,26,26,OLIGO_0000013 | OLIGO_0000048 | OLIGO_0000063,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,source_id,categorical,26,1,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,control_id,categorical,26,6,NON_CONTROL_GENERATED_RECORD | CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FR | CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RIS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,target_gene,string,26,21,SULT1B1 | PCSK9 | STK25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,oligo_modality,string,26,19,GalNAc-siRNA | high_affinity_gapmer_RNaseH1_toxicity_me | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,sequence_length,integer,26,10,22 | 26 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,PS_fraction,float,26,24,0.2136853997268372 | 0.115637955917671 | 0.1532100225465447,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,sugar_chemistry,categorical,26,11,cEt | LNA | unmodified,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,GalNAc_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,off_target_burden_proxy,float,26,22,2.641432527839023 | 2.477738541255538 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,dose_proxy,float,26,24,6.293063088887665 | 3.6025086189026005 | 7.871927332709254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,preclinical_safety_context_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,preclinical_safety_state,categorical,26,6,source_grounded_preclinical_safety_conte | integrated_preclinical_safety_framework | sequence_dependent_gapmer_liver_risk,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,OND_class_context,categorical,26,3,siRNA | ASO_gapmer | therapeutic_oligonucleotide_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,mechanism_class,categorical,26,3,RISC_RNAi | RNase_H_gapmer | mixed_or_general_OND,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,sequence_hybridization_dependency_class,categorical,26,7,sequence_dependent_hybridization_indepen | sequence_and_hybridization_dependent | delivery_or_Cmax_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,risk_domain_label,categorical,26,6,liver_kidney_inflammatory_monitoring | integrated_OND_safety_assessment | liver_sequence_motif_toxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,transcriptome_wide_in_silico_screen_required_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,in_vitro_offtarget_confirmation_required_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,on_target_exaggerated_pharmacology_review_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,cross_species_activity_limitation_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,surrogate_oligo_consideration_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,long_tissue_half_life_effect_duration_context_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,productive_uptake_distribution_label,categorical,26,3,hepatocyte_enriched | liver_kidney_spleen_exposure | delivery_platform_dependent,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,delivery_approach_context,categorical,26,3,GalNAc_ASGR_ASGPR_hepatocyte_targeting | unconjugated_or_not_reported | LNP_formulation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,GalNAc_productive_uptake_multiplier_proxy,float,26,18,25.0 | 2.25 | 2.07,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,LNP_premedication_inflammation_context_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,plasma_Cmax_complement_or_coagulation_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,complement_activation_risk_score_proxy,float,26,26,0.108 | 0.341 | 0.097,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,coagulation_time_risk_score_proxy,float,26,25,0.089 | 0.279 | 0.08,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,sequence_motif_hepatotoxicity_risk_score_proxy,float,26,26,0.562 | 0.551 | 0.206,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,kidney_high_exposure_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,kidney_toxicity_risk_score_proxy,float,26,25,0.148 | 0.361 | 0.137,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,proinflammatory_risk_score_proxy,float,26,24,0.122 | 0.111 | 0.106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,platelet_thrombocytopenia_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,recommended_preclinical_species_context,categorical,26,1,rodent_plus_nonhuman_primate_or_surrogat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,general_toxicology_duration_context,categorical,26,1,early_1_to_3_month_then_chronic_rodent_n,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,preclinical_safety_confidence_score,float,26,1,0.91,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,assumption_id,categorical,26,1,ASM_032,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+preclinical_oligo_safety_assessment.csv,record_origin,categorical,26,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+provenance.csv,provenance_id,string,144,144,PROV_MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PROV_PNPLA3_ROMEO_VALENTI_2025 | PROV_RAPIROSIRAN_SANYAL_2025,Provenance category definitions used across the dataset.
+provenance.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,Provenance category definitions used across the dataset.
+provenance.csv,source_title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,Provenance category definitions used across the dataset.
+provenance.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,Provenance category definitions used across the dataset.
+provenance.csv,doi_or_url,string,144,142,internal_db_bun_alignment_memo | 10.1111/liv.70240 | 10.1016/j.jhep.2025.05.031,Provenance category definitions used across the dataset.
+provenance.csv,source_license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,Provenance category definitions used across the dataset.
+provenance.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,Provenance category definitions used across the dataset.
+provenance.csv,records_generated_from_source,integer,144,29,14 | 16 | 56,Provenance category definitions used across the dataset.
+provenance.csv,source_pdf_redistributed,categorical,144,1,no,Provenance category definitions used across the dataset.
+provenance.csv,source_figures_or_tables_redistributed,categorical,144,1,no,Provenance category definitions used across the dataset.
+provenance.csv,generation_method,categorical,144,1,single_file_configurable_synthetic_harmo,Provenance category definitions used across the dataset.
+provenance.csv,record_origin_default,categorical,144,1,dbbun_generated,Provenance category definitions used across the dataset.
+provenance.csv,output_license,categorical,144,1,CC BY 4.0,Provenance category definitions used across the dataset.
+ps_aso_dna_damage_response.csv,oligo_id,identifier,27,27,OLIGO_0000011 | OLIGO_0000064 | OLIGO_0000079,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,control_id,categorical,27,4,NON_CONTROL_GENERATED_RECORD | CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE | CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,source_id,categorical,27,1,HJELMGREN_PS_ASO_DDR_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,target_gene,string,27,20,PCDHA11 | PCSK9 | PAPD5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,modality,categorical,27,12,PS-ASO_DDR_toxicity_probe | AmNA-modified_ASO | GalNAc-LNP-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,cell_model_context,categorical,27,1,U2OS_HeLa_RPE1_MelJuSo_generated_DDR_scr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,PS_backbone_fraction_proxy,float,27,27,0.8965 | 0.8925 | 0.7339,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,PO_backbone_contrast_flag,integer,27,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,single_stranded_ASO_context_flag,integer,27,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,LNA_gapmer_or_PS_ASO_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,transfection_concentration_nM_proxy,integer,27,2,50.0 | 100.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,PS_body_formation_score_proxy,float,27,27,0.7153 | 0.7071 | 0.432,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,nuclear_filament_context_score_proxy,float,27,27,0.5134 | 0.5089 | 0.3576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,nucleolar_accumulation_score_proxy,float,27,27,0.4219 | 0.4182 | 0.2944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,DNA_PKcs_binding_activation_score_proxy,float,27,27,0.7218 | 0.7144 | 0.457,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,ATM_binding_activation_score_proxy,float,27,27,0.6944 | 0.6868 | 0.4214,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,ATR_activation_score_proxy,float,27,27,0.4572 | 0.4522 | 0.2774,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,PARP1_binding_PARylation_score_proxy,float,27,27,0.7005 | 0.6933 | 0.4478,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,phase_separation_condensate_score_proxy,float,27,27,0.6722 | 0.6657 | 0.4456,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,DNA_break_independent_DDR_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,DNA_damage_marker_absent_from_PSBodies_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,cell_cycle_checkpoint_activation_score_proxy,float,27,27,0.5853 | 0.5801 | 0.3999,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,homologous_recombination_suppression_score_proxy,float,27,27,0.56 | 0.5536 | 0.3323,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,toxic_DNA_lesion_accumulation_score_proxy,float,27,27,0.4803 | 0.4761 | 0.3318,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,radiosensitivity_context_score_proxy,float,27,27,0.3585 | 0.3561 | 0.2724,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,sequence_independence_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,concentration_dependence_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,overall_ASO_DDR_toxicity_mechanism_score_proxy,float,27,27,0.6753 | 0.6681 | 0.4235,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,direct_oligotox_relevance,categorical,27,1,direct_mechanistic_ASO_toxicity_not_live,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,value_origin,categorical,27,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_aso_dna_damage_response.csv,assumption_id,categorical,27,1,ASM_043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,antiviral_potency_score_proxy,float,15,5,0.91743 | 0.4717 | 0.36364,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,assumption_id,categorical,15,1,ASM_061,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,cell_model,categorical,15,1,MT4_HIV1_A6_infection_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,cell_viability_fraction_proxy,float,15,15,0.91634 | 0.92651 | 0.90449,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,challenge_gap_addressed,categorical,15,1,PS_LNA_modification_internalization_and_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,construct,categorical,15,5,PS_only_integrase_target | PS_LNA_5prime_integrase_target | PS_LNA_3prime_conserved_target,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,cytoplasmic_internalization_score_proxy,float,15,15,0.37933 | 0.58669 | 0.89668,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,ic50_uM_proxy,float,15,5,0.09 | 1.12 | 1.75,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,judging_alignment,categorical,15,1,Ability_to_Solve|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,lna_terminal_modification_count,integer,15,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,membrane_sorption_score_proxy,float,15,15,0.40598 | 0.67045 | 0.89485,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,modality,categorical,15,2,PS_ASO_vehicle_free | PS_LNA_ASO_vehicle_free,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,modeling_value,categorical,15,1,"supports ASO chemical-modification, upta",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,modification_tolerability_score_proxy,float,15,15,0.75524 | 0.82457 | 0.90215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,module_record_id,string,15,15,supplemental_HIV_ASO_PS_only_integrase_t | supplemental_HIV_ASO_PS_only_integrase_t | supplemental_HIV_ASO_PS_only_integrase_t,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,phosphorothioate_flag,integer,15,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,source_id,categorical,15,1,GOTFRID_PS_LNA_HIV_ASO_ACTIVITY_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,source_role,categorical,15,1,supporting_ASO_chemistry_internalization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,target_region,categorical,15,2,integrase | conserved_HIV_region,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,timepoint_h,integer,15,3,2 | 24 | 48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,uptake_efficiency_score_proxy,float,15,15,0.39265 | 0.62857 | 0.89576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,value_origin,categorical,15,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ps_lna_hiv_aso_internalization_toxicity.csv,vehicle_free_delivery_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,HSC_activation_score_proxy,float,6,6,0.68 | 0.84 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,PUM1_enriched_exosome_protection_proxy,float,6,6,0.18 | 0.12 | 0.14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,PUM1_state,string,6,5,low | knockdown | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,TPM4_translation_suppression_axis,categorical,6,2,contextual | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,challenge_alignment,categorical,6,1,supports potential-impact and biological,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,fibrosis_relevance,categorical,6,1,supporting_MASLD_fibrosis_liver_injury_c,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,hepatocyte_lipid_deposition_score_proxy,float,6,6,0.78 | 0.86 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,hepatocyte_lipotoxic_death_score_proxy,float,6,6,0.7 | 0.82 | 0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,liver_model_context,string,6,6,human_MASLD_liver | mouse_WD_CCl4 | mouse_CDAHFD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,module_id,categorical,6,1,PUM1_exosome_MASLD_HSC_fibrosis_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,notes,categorical,6,1,Supporting liver-biology context; not tr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,oligo_or_RNA_tool_context,string,6,5,observational | AAV8_shPum1 | PUM1_upregulation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,scenario_id,string,6,6,MASLD_patient_low_PUM1 | WD_CCl4_AAV8_shPum1_aggravation | CDAHFD_AAV8_shPum1_aggravation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,scenario_role,string,6,5,disease_context | injury_aggravation | hepatocyte_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,source_id,categorical,6,1,WAN_PUM1_EXOSOMES_MASLD_HSC_FIBROSIS_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+pum1_exosome_masld_hsc_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,assumption_id,categorical,6,1,ASM_106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,delivery_or_targeting_score_proxy,float,6,6,0.22 | 0.42 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.88 | 0.84,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,modality_or_platform,string,6,6,CRISPR_screen_context | siRNA_knockdown | siRNA_knockdown_or_indisulam,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,model_system,string,6,6,liver_derived_cell_lines | hepatocyte_polyIC_TLR3_model | viral_infection_liver_cell_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,modeling_role,string,6,6,innate_immunity_target_discovery_context | dsRNA_TLR3_response_modulation_context | viral_dsRNA_interferon_response_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,module_id,categorical,6,1,RBM39_hepatocyte_interferon_response_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,primary_effect_score_proxy,float,6,6,0.68 | 0.72 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,scenario_id,string,6,6,genome_wide_TLR3_screen | RBM39_siRNA_knockdown_polyIC_response | viral_infection_ISG_response,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,source_id,categorical,6,1,LI_RBM39_HEPATOCYTE_IFN_INNATE_IMMUNITY_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,toxicity_or_safety_signal_proxy,float,6,5,0.24 | 0.3 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rbm39_hepatocyte_innate_immunity.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+reviewed_not_encoded_sources.csv,source_id,string,1,1,BAO_ARSENIC_IRE1A_ALPHAKG_2025,Sources reviewed but not encoded as direct contributors to the schema.
+reviewed_not_encoded_sources.csv,decision,string,1,1,not_encoded_in,Sources reviewed but not encoded as direct contributors to the schema.
+reviewed_not_encoded_sources.csv,reason,string,1,1,Environmental arsenic developmental hepa,Sources reviewed but not encoded as direct contributors to the schema.
+rna_nanoparticle_hcc_multitarget.csv,oligo_id,identifier,14,14,OLIGO_0000185 | OLIGO_0000198 | OLIGO_0000434,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,control_id,categorical,14,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,source_id,categorical,14,1,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,target_gene,string,14,13,DGAT2 | BCL2 | CYP2E1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,modality,string,14,7,gapmer | GalNAc-siRNA | ASO_PNA_BROTHERS_duplex,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,Hep3B_liver_cancer_context_flag,integer,14,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,carrier_free_platform_flag,integer,14,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,hTERT_mRNA_knockdown_score_proxy,float,14,14,0.75574 | 0.84952 | 0.76193,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,BIRC5_mRNA_knockdown_score_proxy,float,14,14,0.77512 | 0.8713 | 0.78146,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,FGFR1_mRNA_knockdown_score_proxy,float,14,14,0.69761 | 0.78417 | 0.70332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,proliferation_inhibition_score_proxy,float,14,14,0.73636 | 0.82774 | 0.74239,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,migration_inhibition_score_proxy,float,14,14,0.71698 | 0.80595 | 0.72286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,apoptosis_induction_score_proxy,float,14,14,0.60072 | 0.67526 | 0.60564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,xenograft_tumor_growth_inhibition_proxy,float,14,14,0.67823 | 0.76239 | 0.68378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,non_cancer_cell_dose_window_score_proxy,float,14,14,0.56196 | 0.63169 | 0.56656,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,offtarget_toxicity_monitoring_score_proxy,float,14,14,0.69761 | 0.78417 | 0.70332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,challenge_gap_addressed,categorical,14,1,carrier_free_RNAi_platform_liver_cell_ac,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,direct_oligotox_relevance,categorical,14,1,supporting_liver_RNAi_platform_safety_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,value_origin,categorical,14,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,assumption_id,categorical,14,1,ASM_048,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,hash_proxy,float,14,14,0.35888 | 0.94902 | 0.39411,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_nanoparticle_hcc_multitarget.csv,hash_proxy_2,float,14,14,0.16691 | 0.44223 | 0.91066,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,rna_payload_id,string,1120,1120,RNA_CTRL_OLIGO_NEG_VEHICLE_MOCK | RNA_CTRL_OLIGO_NEG_LOW_RISK | RNA_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,rna_payload_type,categorical,1120,6,single_siRNA | single_ASO | dual_siRNA_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,siRNA_payload_fraction,float,1120,47,1.0 | 0.0 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,mRNA_payload_fraction,float,1120,47,0.0 | 0.7 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,pcsk9_knockdown_pct_proxy,float,1120,467,14.25184 | 27.91866 | 4.05302,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,MHC_I_upregulation_fold_proxy,float,1120,1056,0.97161 | 1.60632 | 0.78655,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,antigen_presentation_fold_proxy,float,1120,1050,1.03137 | 1.46579 | 1.40284,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,rna_encapsulation_efficiency,float,1120,962,0.63973 | 0.80919 | 0.64498,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,immune_activation_score,float,1120,986,0.19703 | 0.04427 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,inflammatory_context_score,float,1120,1047,0.19337 | 0.08899 | 0.10056,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,payload_context_note,categorical,1120,1,payload/immunotherapy context; not a mea,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_payload_systems.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,assumption_id,categorical,6,1,ASM_130,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,delivery_interpretation_score_proxy,float,6,6,0.82 | 0.7 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,mechanistic_interpretation,string,6,6,sequence_specific_target_binding | protein_binding_distribution_RNaseH_or_s | sense_passenger_drug_delivery_device_Ago,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,modality_context,string,6,5,ASO_siRNA | ASO | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,module_id,categorical,6,1,RNA_targeted_therapeutics_platform_logic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,notes,string,6,6,Programmability supports rapid design bu | Single-stranded PS ASOs distribute diffe | The antisense guide is pharmacologically,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,platform_feature,string,6,6,Watson_Crick_programmability | ASO_single_stranded_structure | siRNA_double_stranded_prodrug,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,platform_rationale_score_proxy,float,6,6,0.92 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,safety_modeling_complexity_score_proxy,float,6,6,0.54 | 0.62 | 0.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,source_id,categorical,6,1,CROOKE_RNA_TARGETED_THERAPEUTICS_2018,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rna_targeted_therapeutics_platform.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,assumption_id,categorical,6,1,ASM_109,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,delivery_or_targeting_score_proxy,float,6,6,0.3 | 0.86 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,modality_or_platform,string,6,6,AAV_shRNA | GalNAc-siRNA | single_stranded_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,model_system,string,6,6,hepatocyte_directed_AAV8_reporter | liver_AAV_transgene_control | RISC_decoy_reversal_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,modeling_role,string,6,6,vectorized_RNAi_cis_control_design | clinically_validated_liver_RNAi_control | reversible_RNAi_pharmacology_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,module_id,categorical,6,1,RNAi_REVERSIR_AAV_transgene_rheostat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,primary_effect_score_proxy,float,6,5,0.66 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,scenario_id,string,6,6,self_silencing_AAV_shRNA_design | GalNAc_siRNA_transgene_silencing | REVERSIR_rescue_of_RNAi_activity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,source_id,categorical,6,1,SUBRAMANIAN_RNAI_RHEOSTAT_AAV_TRANSGENE_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,toxicity_or_safety_signal_proxy,float,6,3,0.18 | 0.16 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rnai_rheostat_aav_transgene_control.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,assumption_id,categorical,6,1,ASM_112,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,delivery_or_targeting_score_proxy,float,6,5,0.86 | 0.92 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,mechanism_or_specificity_score_proxy,float,6,5,0.84 | 0.9 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,modality_or_platform,string,6,3,GalNAc-LNA-ASO | RNaseH_LNA_ASO | clinical_ASO_safety,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,model_system,string,6,6,phase1_healthy_volunteers | population_PK_liver_exposure_model | liver_exposure_PD_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,modeling_role,string,6,6,clinical_single_dose_safety_and_transami | hepatic_uptake_saturation_and_extrahepat | target_knockdown_PKPD_modeling_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,module_id,categorical,6,1,RO7239958_GalNAc_LNA_ASO_clinical_PKPD_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,primary_effect_score_proxy,float,6,6,0.72 | 0.68 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,scenario_id,string,6,6,healthy_volunteer_single_ascending_dose | ASGPR_saturation_plasma_PK_signal | PAPD5_PAPD7_mRNA_knockdown_prediction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,source_id,categorical,6,1,GERETTI_RO7239958_GALNAC_LNA_ASO_HBV_PHA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,toxicity_or_safety_signal_proxy,float,6,6,0.36 | 0.42 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ro7239958_galnac_lna_aso_hbv_phase1.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,assumption_id,categorical,6,1,ASM_102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,challenge_alignment,categorical,6,1,"supporting module for oligo modality, de",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,delivery_or_targeting_score_proxy,float,6,6,0.2 | 0.42 | 0.44,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,mechanism_or_specificity_score_proxy,float,6,6,0.68 | 0.7 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,modality_or_platform,string,6,3,RPSAP52_non_coding_RNA_target | shRNA_context | LNA_GapmeR_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,model_system,string,6,6,EOC_patient_expression_context | ovarian_cancer_cell_lines | subcutaneous_ova15_or_skov3_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,modeling_role,string,6,6,noncoding_target_prioritization_context | target_validation_context | in_vivo_target_validation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,module_id,categorical,6,1,RPSAP52_LNA_GapmeR_extrahepatic_oncology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,primary_effect_score_proxy,float,6,5,0.72 | 0.76 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,scenario_id,string,6,6,tcga_expression_survival_context | lentiviral_RPSAP52_depletion_cell_growth | lentiviral_RPSAP52_depletion_in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,source_id,categorical,6,1,RAMESH_KUMAR_RPSAP52_LNA_GAPMER_OVARIAN_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,toxicity_or_safety_signal_proxy,float,6,3,0.16 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+rpsap52_lna_gapmer_ovarian_pdox.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,oligo_id,identifier,28,28,OLIGO_0000007 | OLIGO_0000083 | OLIGO_0000095,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,control_id,categorical,28,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,source_id,categorical,28,1,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,target_gene,string,28,20,generic_RNaseH_ASO_target | APOB | generic_offtarget,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,modality,string,28,15,siRNA | ERBB2_DNA_aptamer | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,scpBNA2_or_mixed_scpBNA_scpBNA2_flag,integer,28,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,PS_fraction_proxy,float,28,28,0.61637 | 0.6409 | 0.65639,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,nuclease_stability_score_proxy,float,28,28,0.85496 | 0.88899 | 0.91047,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,target_RNA_knockdown_score_proxy,float,28,28,0.8152 | 0.84764 | 0.86813,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,ALT_fold_ULN_proxy,float,28,28,0.84502 | 0.87865 | 0.89989,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,AST_fold_ULN_proxy,float,28,28,0.89473 | 0.93033 | 0.95282,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,activity_safety_window_score_proxy,float,28,28,0.77543 | 0.80629 | 0.82578,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,direct_oligotox_relevance,categorical,28,1,direct_ASO_chemistry_hepatotoxicity_redu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,value_origin,categorical,28,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,assumption_id,categorical,28,1,ASM_045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+scpBNA2_aso_chemistry_safety.csv,hash_proxy,float,28,28,0.46069 | 0.73461 | 0.91768,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,sequence_toxicity_id,string,1120,1120,SEQTOX_CTRL_OLIGO_NEG_VEHICLE_MOCK | SEQTOX_CTRL_OLIGO_NEG_LOW_RISK | SEQTOX_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,sequence_modification_toxicity_state,categorical,1120,5,baseline_sequence_toxicity_not_modeled | LNA_PS_gapmer_high_hepatotoxic_potential | sequence_redesign_lower_toxicity_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,lna_gapmer_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,phosphorothioate_full_backbone_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,dinucleotide_feature_encoding,categorical,1120,2,not_modeled | 64_dinucleotide_count_vector_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,toxic_gap_motif_count_proxy,integer,1120,11,0 | 1 | 9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,protective_or_lower_risk_motif_count_proxy,integer,1120,17,0 | 14 | 6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,model_family,categorical,1120,2,not_modeled | random_forest_style_dinucleotide_classif,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,training_set_oligo_count_proxy,integer,1120,2,0 | 206,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,screened_oligo_count_proxy,integer,1120,2,0 | 236,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,independent_validation_count_proxy,integer,1120,2,0 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,oob_accuracy_proxy,float,1120,2,0.0 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,validation_accuracy_proxy,float,1120,2,0.0 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,ALT_ULN_lowtox_threshold_fold_proxy,integer,1120,2,0.0 | 2.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,ALT_ULN_hightox_threshold_fold_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,predicted_sequence_hepatotoxicity_probability_proxy,float,1120,178,0.0 | 0.97633 | 0.98839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,predicted_ALT_fold_from_sequence_model_proxy,float,1120,178,1.0 | 9.45655 | 10.18815,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,predicted_sequence_toxicity_class,categorical,1120,3,not_modeled | high_toxicity_potential | low_toxicity_potential,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,nearest_training_edit_distance_proxy,integer,1120,9,0 | 4 | 8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,prediction_confidence_by_distance_label,categorical,1120,4,not_modeled | medium_distance_moderate_confidence | far_distance_lower_confidence,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,prediction_accuracy_by_distance_proxy,float,1120,4,0.0 | 0.8 | 0.69,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,redesign_to_lower_toxicity_applicable,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,sequence_redesign_risk_reduction_proxy,float,1120,168,0.0 | 0.50842 | 0.72601,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,sequence_modification_toxicity_modifier,float,1120,178,0.0 | 0.93745 | 0.82256,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,context_note,categorical,1120,2,sequence/modification hepatotoxicity pre | sequence/modification toxicity context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sequence_modification_toxicity.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,oligo_id,identifier,17,17,OLIGO_0000038 | OLIGO_0000157 | OLIGO_0000231,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,control_id,categorical,17,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,source_id,categorical,17,1,LIU_CYP2E1_LNP_APAP_AILI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,target_gene,string,17,12,DGAT2 | generic_offtarget | PAPD7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,modality,string,17,11,siCyp2e1_LNP | PS-ASO_DDR_toxicity_probe | long_acting_GalNAc_APOC3_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,APAP_acute_liver_injury_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,Cyp2e1_mRNA_knockdown_score_proxy,float,17,17,0.95757 | 0.92687 | 0.91553,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,serum_ALT_fold_ULN_proxy,float,17,17,1.19697 | 1.15858 | 1.14441,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,serum_AST_fold_ULN_proxy,float,17,17,1.24901 | 1.20896 | 1.19417,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,ROS_score_proxy,float,17,17,0.26021 | 0.25187 | 0.24879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,overall_APAP_AILI_rescue_score_proxy,float,17,17,0.85349 | 0.82612 | 0.81602,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,direct_oligotox_relevance,categorical,17,1,direct_liver_injury_RNAi_intervention_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,value_origin,categorical,17,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,assumption_id,categorical,17,1,ASM_046,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+siCyp2e1_lnp_apap_aili.csv,hash_proxy,float,17,17,0.78611 | 0.55073 | 0.46737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,sirna_bulge_state,categorical,1120,7,not_modeled | guide_passenger_1nt_bulge_tolerated | galnac_ttr_position14_bulge_in_vivo_acti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,guide_strand_bulge_mode,categorical,1120,4,not_applicable | guide_passenger_duplex | guide_target_duplex_degenerate_target,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,bulge_length_nt_proxy,integer,1120,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,bulge_position_guide_nt_proxy,integer,1120,18,0 | 13 | 14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,bulge_region_label,categorical,1120,7,not_applicable | tolerated_nonseed_region | central_3prime_side_position14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,guide_strand_sequence_unchanged_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,passenger_strand_shortening_design_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,modified_sirna_OMe_F_PS_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,galnac_conjugated_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,receptor_mediated_hepatocyte_uptake_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,melting_temperature_reduction_K_proxy,float,1120,238,0.0 | 14.0 | 10.53559,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,in_vitro_target_repression_score_proxy,float,1120,358,0.0 | 0.8093 | 0.93721,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,in_vivo_target_repression_score_proxy,float,1120,346,0.0 | 0.32645 | 0.8434,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,offtarget_degenerate_target_repression_score_proxy,float,1120,350,0.0 | 0.04427 | 0.14515,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,offtarget_prediction_include_deletions_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,seed_region_bulge_tolerability_score_proxy,float,1120,312,0.0 | 0.49133 | 0.71539,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,central_region_bulge_tolerability_score_proxy,float,1120,177,0.0 | 0.7 | 0.38312,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,terminal_region_bulge_tolerability_score_proxy,float,1120,281,0.0 | 0.61669 | 0.38418,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,bulge_related_offtarget_risk_modifier,float,1120,350,0.0 | 0.214 | 0.17,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,bulge_related_activity_modifier,float,1120,5,0.0 | 0.03 | -0.06,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,sirna_bulge_context_confidence_score,float,1120,364,0.0 | 0.74241 | 0.70953,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,context_note,categorical,1120,3,No siRNA bulge/off-target context assign | Supporting siRNA design/off-target-predi | Supporting siRNA bulge context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_bulge_offtarget_tolerance.csv,value_origin,categorical,1120,4,not_reported | literature_grounded_generated | inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,oligo_id,string,4,4,OLIGO_CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHA | OLIGO_CTRL_CONTEXT_SIRNA_PKPD_BARRIERS | OLIGO_CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,control_id,string,4,4,CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM | CTRL_CONTEXT_SIRNA_PKPD_BARRIERS | CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCRE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,source_id,categorical,4,1,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,target_gene,string,4,4,RISC_AGO2_siRNA_mechanism_proxy | NAKED_SIRNA_PKPD_BARRIER_PROXY | SIRNA_IMMUNE_OFFTARGET_SCREENING_PROXY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,modality,string,4,3,GalNAc-siRNA | naked-siRNA | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,sequence_length,integer,4,1,21,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,dose,integer,4,2,5.0 | 25.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,hepatotox_score,float,4,4,0.8 | 2.4 | 4.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,hepatotoxicity_label,string,4,2,low | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,value_origin,categorical,4,1,literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,assumption_id,categorical,4,1,ASM_037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,sirna_review_state,categorical,4,1,encoded,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,siRNA_duplex_structure_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,guide_strand_RISC_loading_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,AGO2_mRNA_cleavage_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,seed_region_nt2_8_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,central_region_nt9_12_cleavage_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,supplementary_region_nt13_17_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,naked_siRNA_rapid_renal_clearance_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,nuclease_degradation_barrier_score_proxy,float,4,3,0.18 | 0.78 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,endosomal_escape_limitation_score_proxy,float,4,2,0.7 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,chemical_stabilization_score_proxy,float,4,3,0.8944 | 0.724 | 0.7144,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,GalNAc_ASGPR_delivery_context_flag,integer,4,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,LNP_delivery_context_flag,integer,4,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,immune_activation_TLR_cytokine_risk_proxy,float,4,3,0.0516 | 0.306 | 0.1396,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,seed_region_offtarget_silencing_risk_proxy,float,4,4,0.204 | 0.616 | 0.76286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,RISC_miRNA_pathway_competition_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,delivery_success_score_proxy,float,4,3,0.74 | 0.0 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,clinical_translation_context_score_proxy,float,4,3,0.4 | 0.2 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,approved_or_late_stage_siRNA_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirna_pharmacology_clinical_development_context.csv,sirna_pharmacology_context_confidence_score,float,4,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,oligo_id,identifier,11,11,OLIGO_0000050 | OLIGO_0000097 | OLIGO_0000188,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,control_id,categorical,11,4,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNC | CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,source_id,categorical,11,1,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,target_gene,categorical,11,1,RUBICON,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,modality,categorical,11,1,ROS-responsive_GalNAc-siRNA_nanoparticle,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,delivery_platform,categorical,11,1,PPH-PEI_GalNAc_siRNA_generated_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,ROS_responsive_shell_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,PEI25k_GalNAc_core_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,GalNAc_ASGPR_hepatocyte_targeting_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,PEGylated_negative_surface_circulation_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,MASH_oxidative_microenvironment_context_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,ROS_triggered_shell_disassembly_score_proxy,float,11,11,0.867 | 0.6704 | 0.8883,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,ASGPR_hepatocyte_uptake_score_proxy,float,11,11,0.9341 | 0.878 | 0.7606,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,hepatocyte_selectivity_score_proxy,float,11,11,0.9483 | 0.8792 | 0.9234,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,nonparenchymal_cell_sparing_score_proxy,float,11,11,0.744 | 0.7299 | 0.7342,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,Rubicon_knockdown_score_proxy,float,11,11,0.8466 | 0.7671 | 0.839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,lipophagy_activation_score_proxy,float,11,11,0.7249 | 0.6756 | 0.7202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,hepatic_steatosis_reduction_score_proxy,float,11,11,0.6149 | 0.5854 | 0.6121,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,ALT_relative_to_MASH_control_proxy,float,11,11,0.8548 | 0.8644 | 0.8564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,AST_relative_to_MASH_control_proxy,float,11,11,0.8932 | 0.9019 | 0.8948,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,albumin_relative_to_MASH_control_proxy,float,11,10,1.1158 | 1.1108 | 1.1152,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,liver_accumulation_score_proxy,float,11,11,0.8495 | 0.7747 | 0.8576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,lung_accumulation_monitoring_score_proxy,float,11,11,0.3131 | 0.2119 | 0.324,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,heart_kidney_change_low_context_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,offtarget_organ_retention_score_proxy,float,11,11,0.3159 | 0.2316 | 0.325,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,PEI_cationic_vector_cytotoxicity_monitoring_score_proxy,float,11,11,0.1432 | 0.1263 | 0.145,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,nanocarrier_immune_clearance_monitoring_score_proxy,float,11,11,0.2021 | 0.1802 | 0.2045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,overall_delivery_benefit_minus_safety_risk_score_proxy,float,11,11,0.4921 | 0.4754 | 0.4825,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,direct_oligotox_relevance,categorical,11,1,supporting_liver_targeted_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,value_origin,categorical,11,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sirubicon_ros_galnac_mash_delivery.csv,assumption_id,categorical,11,1,ASM_044,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,ALP_signal_score_proxy,float,7,7,0.05 | 0.12 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,ALT_signal_score_proxy,float,7,7,0.08 | 0.16 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,challenge_alignment,categorical,7,1,directly supports ability-to-solve and r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,immune_or_complement_activation_score_proxy,float,7,6,0.02 | 0.08 | 0.1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,microscopic_platform_effect_score_proxy,float,7,6,0.03 | 0.12 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,modeling_role,string,7,7,specific_target_knockdown_no_relevant_of | liver_targeted_distribution | known_platform_distribution_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,module_id,categorical,7,1,SLN360_GalNAc_siRNA_preclinical_toxicolo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,notes,categorical,7,1,Generated preclinical-safety scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,offtarget_screening_included,categorical,7,1,yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,oligo_modality,categorical,7,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,primary_tissue_or_matrix,string,7,6,primary_human_hepatocyte | liver | kidney,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,reversibility_or_nonadverse_label,categorical,7,1,reversible_or_nonadverse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,scenario_id,string,7,7,primary_human_hepatocyte_specificity | rat_liver_distribution_peak | rat_kidney_distribution_peak,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,source_id,categorical,7,1,RIDER_SLN360_LPA_GALNAC_SIRNA_PRECLINICA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,species_relevance,categorical,7,1,human|rat|cynomolgus_monkey,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,study_context,string,7,6,in_vitro | rat_PK_TK | rat_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,target_knockdown_or_PD_score_proxy,float,7,7,0.9 | 0.78 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,target_or_safety_endpoint,string,7,7,LPA_mRNA | LPA_surrogate_context | non_target_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sln360_galnac_sirna_preclinical_toxicology.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,aso_chemistry_context,string,6,6,PS_DNA_gapmer | SNA2_PS_gapmer | SNA4_PS_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,challenge_alignment,categorical,6,1,"supports chemistry/delivery coverage, sy",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,liver_damage_liability_score_proxy,float,6,6,0.18 | 0.14 | 0.13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,module_id,categorical,6,1,SNA_ASO_systemic_delivery_safety_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,notes,categorical,6,1,Supporting ASO chemistry and systemic sa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,nuclease_resistance_score_proxy,float,6,6,0.4 | 0.72 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,organ_uptake_score_proxy,float,6,6,0.34 | 0.7 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,pharmacodynamic_glucosuria_score_proxy,float,6,6,0.3 | 0.63 | 0.73,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,primary_organ_context,string,6,4,kidney_proximal_tubule | kidney_and_liver | renal_proximal_tubule,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,rnaseH1_gapmer_mechanism_context,categorical,6,1,yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,safety_interpretation,categorical,6,2,no_severe_liver_damage_proxy | higher_liver_damage_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,scenario_id,string,6,6,SGLT2_DNA_ASO_reference | SGLT2_SNA2_ASO | SGLT2_SNA4_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,scenario_role,string,6,6,reference_ASO | improved_stability_and_activity | high_renal_uptake_and_prolonged_activity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,source_id,categorical,6,1,TSUBOI_SNA_ASO_SGLT2_KIDNEY_SYSTEMIC_SAF,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,target_gene,categorical,6,1,SGLT2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,target_knockdown_score_proxy,float,6,6,0.38 | 0.68 | 0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sna_aso_kidney_systemic_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+source_corpus_access_statement.csv,assumption_id,identifier,1,1,ASM_131,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,future_work_note,string,1,1,Paywalled or inaccessible papers are not,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,original_filenames_in_outputs,string,1,1,no,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,pdf_uploads_total_in_conversation_after_supplement,integer,1,1,151,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,source_identifier_policy,string,1,1,paper_title_short_title_source_id_only,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,statement,string,1,1,The source corpus for this version was a,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,statement_id,string,1,1,CORPUS_ACCESS_BOUNDARY,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,statement_type,string,1,1,source_corpus_boundary,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,supplemental_pdf_count,integer,1,1,8,Statement of source corpus access boundary (open-access only).
+source_corpus_access_statement.csv,supplemental_pdf_size_mb_title_based,float,1,1,23.28627,Statement of source corpus access boundary (open-access only).
+source_triage_log.csv,decision,categorical,5,2,defer | add_supporting,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,judging_use,categorical,144,1,supports rigor/transparency by documenti,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,module_added,string,5,3,no | rpsap52_lna_gapmer_ovarian_pdox.csv | biologics_hyb_targeted_rna_delivery.csv,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,phase2_fit,string,5,5,low_to_moderate_context_only | low_context_only | moderate_supporting_ASO_modality_safety,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,reason,string,149,149,"Defines target tables, predictors, contr | Adds PNPLA3 I148M genotype context, homo | Strengthened from uploaded paper: phase ","Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,source_id,string,149,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+source_triage_log.csv,triage_decision,categorical,144,4,include_context_metadata | include_supporting_module_or_context | include_full_or_direct_module,"Documentation of source-level inclusion, deferral, and exclusion decisions."
+sources.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,year,integer,144,12,2026 | 2025 | 2023,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,doi_or_url,string,144,142,internal_db_bun_alignment_memo | 10.1111/liv.70240 | 10.1016/j.jhep.2025.05.031,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,modality_focus,string,144,144,ASO|gapmer|siRNA|GalNAc-siRNA | siRNA|ASO | GalNAc-siRNA|HSD17B13|rapirosiran|MASH|A,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,hepatotoxicity_relevance,string,144,143,governing | supporting_liver_genetics_MASLD_precisio | directly_relevant_clinical_low_DILI_GalN,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,use_in_core_dataset,string,144,52,yes | supporting | yes_core_clinical_PK_PD_safety_module,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,notes,string,144,144,"Defines target tables, predictors, contr | Adds PNPLA3 I148M genotype context, homo | Strengthened from uploaded paper: phase ","Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,record_origin,categorical,144,1,source_metadata,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,original_pdf_redistributed,categorical,144,1,no,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,license_for_generated_output,categorical,144,1,CC BY 4.0,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,primary_modality,string,4,4,small_molecule_hepatoprotective_context_ | calcium_phosphate_hybrid_nanoparticle_si | engineered_small_extracellular_vesicle_s,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,disease_context,string,4,4,alcohol_related_liver_disease | luminal_A_breast_cancer | RNA_therapeutics_and_hepatic_Pcsk9_chole,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,direct_oligotox_relevance,string,4,4,supporting_aldehyde_detoxification_oxida | supporting_delivery_platform_safety_and_ | supporting_sEV_RNA_loading_hepatocyte_de,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,key_relevance,string,4,4,"ALDH2 activity, acetaldehyde detoxificat | Calcium phosphate/PEG-pGlu hybrid nanopa | PMEVL uses N-myristoylation peptides to ","Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,weight_in_generation,float,4,4,0.42 | 0.34 | 0.36,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,short_name,string,5,5,Kamola ASO hepatotox screen 2017 | Endothelial AGO1 LNP-ASO 2025 | GYS1 ASO Pompe preprint 2024,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,citation,string,5,5,Kamola PJ et al. Strategies for in vivo  | Liu X et al. Endothelial AGO1 Drives Vas | Weiss L et al. Skeletal muscle effects o,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,primary_topic,string,5,5,"ASO gapmer hepatotoxicity, acute mouse s | endothelial AGO1 inhibition with LNP-del | systemic cEt gapmer ASO targeting Gys1 a","Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,oligo_modality,string,5,5,LNA_gapmer_ASO | LNA_gapmer_ASO_in_LNP | PS_cEt_RNase_H1_gapmer_ASO,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,liver_context,string,5,5,mouse liver hepatotoxicity screening; pl | AAV9-PCSK9 plus high-fat/high-cholestero | not liver-targeted; includes systemic to,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,evidence_level,string,5,5,preclinical_mechanistic_safety_screening | preprint_preclinical_mechanistic_and_the | preprint_preclinical_mouse_supporting_co,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,phase2_relevance,string,5,5,"core_experimental_design_controls_and_tr | supporting_controls_translatability_deli | supports experimental design, negative c","Literature source metadata: paper titles, source IDs, relevance category, license."
+sources.csv,included_in_generation,categorical,5,1,True,"Literature source metadata: paper titles, source IDs, relevance category, license."
+sptlc2_lnp_sirna_mash_ceramide.csv,assumption_id,categorical,6,1,ASM_116,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,delivery_or_targeting_score_proxy,float,6,5,0.28 | 0.84 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,modality_or_platform,categorical,6,2,target_discovery_context | LNP-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,model_system,string,6,6,human_MASLD_MASH_liver_lipidomics_snRNAs | hepatocyte_targeted_delivery_model | MASH_mouse_liver_lipidomics,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,modeling_role,string,6,6,human_liver_target_prioritization_contex | hepatocyte_delivery_and_knockdown_contex | mechanistic_lipid_toxicity_readout,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,module_id,categorical,6,1,SPTLC2_LNP_siRNA_MASH_ceramide_liver_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,primary_effect_score_proxy,float,6,6,0.78 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,scenario_id,string,6,6,human_MASLD_ceramide_SPTLC2_signal | LNP_SPTLC2_siRNA_hepatocyte_delivery | hepatic_ceramide_reduction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,source_id,categorical,6,1,YU_SPTLC2_LNP_SIRNA_MASH_CERAMIDE_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,toxicity_or_safety_signal_proxy,float,6,4,0.3 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+sptlc2_lnp_sirna_mash_ceramide.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+supplemental_source_decisions.csv,access_basis,categorical,8,1,open_access_or_freely_downloadable_pdf_a,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,doi_or_url,string,8,8,10.1089/nat.2024.0090 | 10.1093/nar/gkad067 | 10.1016/j.jhep.2024.12.046,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,filename_stored_or_displayed,categorical,8,1,no,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,incorporation_decision,string,8,5,row_level_module_added | row_level_reference_module_added | platform_module_added,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,module_or_table,string,8,7,galnac_sirna_risc_offtarget_mechanism.cs | approved_oligo_chemistry_landscape.csv | pnpla3_azd2693_precision_mash.csv,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,paper_title,string,8,8,"Mechanistic Insights into Hybridization- | Chemistry, Structure and Function of App | AZD2693, a PNPLA3 antisense oligonucleot",Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,rationale,string,8,8,High-priority mechanistic source for AGO | Standardizes approved-oligo chemistry an | Original clinical/preclinical PNPLA3 ASO,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,short_title,string,8,8,agarwal-galnac-sirna-offtarget-2025 | egli-manoharan-approved-oligo-chemistry- | armisen-azd2693-pnpla3-aso-mash-2025,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,source_category,string,8,5,core | core_reference | supporting,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,source_id,string,8,8,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025 | EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_ | ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,source_pdf_size_mb,float,8,8,1.64399 | 10.07143 | 1.27878,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,value_origin,categorical,8,1,source_inventory_metadata,Supplemental literature triage decisions and reasoning.
+supplemental_source_decisions.csv,year,integer,8,5,2025 | 2023 | 2018,Supplemental literature triage decisions and reasoning.
+systemic_hdo_drg_sciatic_delivery.csv,RNase_H1_release_logic,categorical,7,2,direct_ASO_RNase_H1_target_degradation | cRNA_cleavage_releases_ASO_then_RNase_H1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,challenge_alignment,categorical,7,1,supports impact and rigor by adding olig,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,delivery_ligand_or_duplex_design,categorical,7,2,single_stranded_parent_gapmer_ASO | alpha_tocopherol_conjugated_cRNA_duplexe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,dose_regimen,categorical,7,3,single | weekly_x4 | systemic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,extrahepatic_distribution_score_proxy,float,7,7,0.2 | 0.42 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,modeling_role,string,7,7,parent_ASO_reference | enhanced_HDO_delivery | parent_repeated_reference,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,module_id,categorical,7,1,systemic_Toc_HDO_DRG_sciatic_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,nominal_ASO_equivalent_dose_mg_per_kg,float,7,2,50.0 | 12.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,notes,categorical,7,1,Generated delivery scenario row; proxy v,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,oligo_modality,categorical,7,2,ASO | Toc_HDO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,potency_improvement_vs_parent_ASO_score_proxy,float,7,6,0.2 | 0.38 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,safety_modeling_relevance,categorical,7,1,adds_extrahepatic_biodistribution_and_pe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,scenario_id,string,7,7,Malat1_parent_ASO_single_50mgkg_lumbar_D | Malat1_Toc_HDO_single_50mgkg_lumbar_DRG | Malat1_parent_ASO_repeated_12_5mgkg_cerv,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,source_id,categorical,7,1,KABURAGI_TOC_HDO_DRG_SCIATIC_SYSTEMIC_DE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,target_knockdown_score_proxy,float,7,7,0.55 | 0.86 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,target_tissue,string,7,5,lumbar_DRG | cervical_DRG | lumbar_and_cervical_DRG,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,target_transcript,string,7,4,Malat1 | Dmpk | Scarb1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+systemic_hdo_drg_sciatic_delivery.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,assumption_id,categorical,6,1,ASM_121,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,delivery_or_targeting_score_proxy,float,6,4,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,mechanism_or_specificity_score_proxy,float,6,5,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,modality_or_platform,string,6,6,hybrid_lipid_nanovesicle_siRNA_delivery | siRNA_delivery | delivery_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,model_system,string,6,6,HCC_TDEV_membrane_DPPC_LEV_platform | Sk_hep1_HCC_parent_cell_homing_model | HCC_cell_internalization_pathway,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,modeling_role,string,6,6,advanced_delivery_vehicle_design_context | tumor_selective_delivery_context | cell_entry_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,module_id,categorical,6,1,TDEV_membrane_hybrid_lipid_nanovesicle_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,primary_effect_score_proxy,float,6,5,0.7 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,scenario_id,string,6,6,TDEV_membrane_hybrid_LEV_design | parent_HCC_tumor_homing | HSPG_mediated_internalization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,source_id,categorical,6,1,ZHOU_TDEV_MEMBRANE_LEV_SIRNA_HCC_DELIVER,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,toxicity_or_safety_signal_proxy,float,6,4,0.24 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tdev_membrane_lev_sirna_hcc_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,assumption_id,categorical,6,1,ASM_119,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,delivery_or_targeting_score_proxy,float,6,5,0.16 | 0.32 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,mechanism_or_specificity_score_proxy,float,6,5,0.78 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,modality_or_platform,string,6,5,liver_injury_context | siRNA_knockdown | protein_crosslinking_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,model_system,string,6,6,HepG2_and_primary_hepatocyte_GCDCA_model | GCDCA_treated_HepG2_cells | keratin_hepatocyte_death_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,modeling_role,string,6,6,cholestatic_bile_acid_apoptosis_readout_ | mechanistic_knockdown_reversal_context | cytoskeletal_apoptosis_pathway_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,module_id,categorical,6,1,TG1_TG2_K18_K8_bile_acid_hepatocyte_apop,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,primary_effect_score_proxy,float,6,6,0.7 | 0.74 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,scenario_id,string,6,6,GCDCA_dose_dependent_hepatocyte_apoptosi | TG1_TG2_siRNA_apoptosis_attenuation | K18_K8_siRNA_protective_effect,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,source_id,categorical,6,1,TATSUKAWA_TG_KERATIN_BILE_ACID_HEPATOCYT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,toxicity_or_safety_signal_proxy,float,6,6,0.58 | 0.34 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+tg_keratin_bile_acid_hepatocyte_death.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,assumption_id,categorical,6,1,ASM_118,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,delivery_or_targeting_score_proxy,float,6,4,0.2 | 0.18 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,mechanism_or_specificity_score_proxy,float,6,3,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,modality_or_platform,string,6,6,proteomics_biomarker_context | biomarker_context | siRNA_knockdown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,model_system,string,6,6,rat_radiation_induced_liver_injury | radiation_dose_RILI_plasma_liver_correla | BRL_BRL3A_THLE2_hepatocyte_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,modeling_role,string,6,6,liver_injury_biomarker_discovery_context | injury_monitoring_readout_context | mechanistic_target_validation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,module_id,categorical,6,1,THBS1_RILI_proteomics_siRNA_fibrosis_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,primary_effect_score_proxy,float,6,5,0.72 | 0.76 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,scenario_id,string,6,6,RILI_TMT_proteomics_biomarker_screen | THBS1_plasma_tissue_dose_response | THBS1_siRNA_knockdown_hepatocytes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,source_id,categorical,6,1,WANG_THBS1_RILI_PROTEOMICS_SIRNA_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,toxicity_or_safety_signal_proxy,float,6,6,0.42 | 0.48 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+thbs1_rili_proteomics_sirna.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+toxicity_readouts.csv,readout_id,string,16800,16800,READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R1 | READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R2 | READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R3,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,assay_id,string,16800,5600,ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T72 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T168,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,oligo_id,string,16800,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,source_id,string,16800,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,control_id,string,16800,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,time_hours,integer,16800,5,24 | 72 | 168,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,replicate_id,integer,16800,3,1 | 2 | 3,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,viability_pct,float,16800,16800,85.99561595094147 | 91.06775186321384 | 85.49070622192647,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,ALT_AST_proxy_fold_change,float,16800,16800,1.9788627647805892 | 1.5715849901010643 | 1.626738080633759,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,apoptosis_score,float,16800,16800,0.298932836512114 | 0.2977209242066459 | 0.3577897617808117,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,stress_response_score,float,16800,16800,0.3283811496058296 | 0.3425986449232235 | 0.5688441746526677,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,transcriptomic_perturbation_score,float,16800,16795,0.2396605765951162 | 0.2399277160889206 | 0.3171385261514008,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,immune_activation_score,float,16800,15136,0.2154366846768191 | 0.1827922881801677 | 0.1664045783582166,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,inflammatory_context_score,float,16800,16021,0.236647832095342 | 0.1996169007156055 | 0.2366170013904089,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,overall_hepatotoxicity_risk_score,float,16800,16800,2.6518167631613823 | 2.2405881055627197 | 2.8658984364223388,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,hepatotoxicity_label,categorical,16800,3,low | moderate | high,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,measured_experimental_value,categorical,16800,1,no,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,record_origin,categorical,16800,1,dbbun_generated,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,value_origin,categorical,16800,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,provenance_label,categorical,16800,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,assumption_id,identifier,16800,30,ASM_007 | ASM_018 | ASM_019,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+toxicity_readouts.csv,confidence_level,float,16800,936,0.88 | 0.9 | 0.82,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
+trim16_yap1_nrf2_septic_liver_injury.csv,assumption_id,categorical,6,1,ASM_120,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,delivery_or_targeting_score_proxy,float,6,6,0.18 | 0.34 | 0.52,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,mechanism_or_specificity_score_proxy,float,6,4,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,modality_or_platform,string,6,6,liver_injury_context | siRNA_knockdown | AAV9_overexpression,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,model_system,string,6,6,LPS_injured_hepatocyte_model | LPS_hepatocyte_injury_model | CLP_septic_liver_injury_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,modeling_role,string,6,6,acute_inflammatory_hepatocyte_stress_con | knockdown_worsening_safety_axis_context | rescue_and_liver_function_boundary_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,module_id,categorical,6,1,TRIM16_YAP1_NRF2_septic_liver_injury_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,primary_effect_score_proxy,float,6,5,0.68 | 0.7 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,scenario_id,string,6,6,LPS_reduces_TRIM16_hepatocyte_stress | TRIM16_siRNA_exacerbates_ALT_AST | TRIM16_overexpression_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,source_id,categorical,6,1,ZHANG_TRIM16_YAP1_NRF2_SEPTIC_LIVER_INJU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,toxicity_or_safety_signal_proxy,float,6,6,0.54 | 0.58 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trim16_yap1_nrf2_septic_liver_injury.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,assumption_id,categorical,5,1,ASM_083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,cellular_uptake_score_proxy,float,5,5,0.1 | 0.65 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,challenge_alignment,categorical,5,1,supports impact by adding an alternative,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,cytotoxicity_score_proxy,float,5,4,0.1 | 0.22 | 0.12,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,delivery_efficiency_score_proxy,float,5,5,0.1 | 0.55 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,delivery_strategy,string,5,5,none | commercial_lipofection | trivalent_disulfide_masked,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,endocytosis_independent_context,categorical,5,2,no_or_not_primary | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,liver_distribution_context,categorical,5,2,yes | not_primary_endpoint,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,model_system,categorical,5,2,HeLa_S3 | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,modeling_role,string,5,5,negative_delivery_reference | commercial_delivery_comparator | enhanced_delivery_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,module_id,categorical,5,1,trivalent_disulfide_ODN_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,notes,categorical,5,1,Generated delivery-chemistry scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,observed_toxicity_score_proxy,float,5,5,0.05 | 0.2 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,payload_or_probe,categorical,5,2,ODN_FAM | SS-ODN_FAM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,scenario_id,string,5,5,ODN_FAM_no_delivery | Lipo2000_ODN_FAM | SS_ODN_FAM_trivalent_disulfide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,source_id,categorical,5,1,WANG_TRIVALENT_DISULFIDE_MASKED_ODN_DELI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,thiol_exchange_dependency_score_proxy,float,5,5,0.05 | 0.25 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+trivalent_disulfide_odn_delivery.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,assumption_id,categorical,6,1,ASM_100,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,challenge_alignment,categorical,6,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,delivery_or_targeting_score_proxy,float,6,6,0.9 | 0.75 | 0.65,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,immune_or_cell_state_score_proxy,float,6,6,0.55 | 0.5 | 0.68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,modality_or_platform,string,6,3,TY1_C2_casein_chitosan_micelles | TY1_C2_oral | C2_formulated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,model_system,string,6,6,in_vitro_formulation | healthy_mouse | rat_myocardial_infarction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,modeling_role,string,6,6,encapsulation_and_enzyme_protection | tolerability_liver_enzyme_histology_cont | disease_modifying_activity_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,module_id,categorical,6,1,TY1_oral_ncRNA_macrophage_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,primary_effect_score_proxy,float,6,6,0.95 | 0.8 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,scenario_id,string,6,6,TY1C2_encapsulation_protection | healthy_mouse_chronic_oral_tolerability | rat_MI_single_oral_dose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,source_id,categorical,6,1,YAMAGUCHI_TY1_ORAL_NCRNA_MACROPHAGE_C2_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,toxicity_or_safety_signal_proxy,float,6,5,0.12 | 0.1 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+ty1_oral_ncrna_macrophage_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+validation_summary.csv,metric,string,385,27,row_count | hepatotoxicity_label_count | control_present_in_oligos,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
+validation_summary.csv,status,categorical,385,3,ok | warning_missing | review_needed,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
+validation_summary.csv,table_name,string,385,126,sources.csv | controls.csv | oligos.csv,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
+validation_summary.csv,value,string,385,288,144 | 161 | 1120,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
+xist_hsc_ferroptosis_fibrosis.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.18 | 0.82 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,GPX4_activity_score_proxy,float,6,6,0.18 | 0.85 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,HSC_activation_score_proxy,float,6,6,0.15 | 0.8 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,RNA_axis,categorical,6,1,lncRNA_XIST_sponges_miR-663a_to_upregula,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,challenge_alignment,categorical,6,1,supports potential impact and biological,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,ferroptosis_score_proxy,float,6,6,0.25 | 0.2 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,fibrosis_score_proxy,float,6,6,0.1 | 0.82 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,hydroxyproline_HYP_fibrosis_score_proxy,float,6,6,0.1 | 0.75 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,intervention_or_perturbation,string,6,6,none | ethanol | si-XIST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,model_system,categorical,6,2,LX-2_HSC | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,modeling_role,string,6,6,baseline_control | activated_HSC_positive_context | XIST_knockdown_ferroptosis_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,module_id,categorical,6,1,XIST_miR663a_GPX4_HSC_ferroptosis_fibros,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,notes,categorical,6,1,Generated fibrosis/ferroptosis scenario ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,oligo_or_RNA_tool,categorical,6,2,none | siRNA_or_shRNA_or_miRNA_antagonist,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,readout_family,categorical,6,1,alpha_SMA|CoL1A1|GPX4|Fe2+|MDA|GSH|ALT|A,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,scenario_id,string,6,6,control_LX2 | ethanol_activated_LX2 | ethanol_si_XIST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,source_id,categorical,6,1,DAI_XIST_MIR663A_GPX4_HSC_FERROPTOSIS_FI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+xist_hsc_ferroptosis_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_state,categorical,1120,5,not_zilebesiran_or_AGT_context | zilebesiran_like_low_direct_hepatotoxici | RAAS_systemic_safety_monitoring_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_clinical_context,categorical,1120,2,not_applicable | hypertension_AGT_siRNA_RAAS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_target_gene,categorical,1120,2,not_applicable | AGT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_target_mRNA,categorical,1120,2,not_applicable | angiotensinogen_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_route,categorical,1120,2,not_applicable | subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_GalNAc_ASGPR_hepatocyte_delivery_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_clathrin_endocytosis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_endosomal_depot_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_RISC_recycling_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_single_dose_mg_proxy,float,1120,7,0.0 | 300.0 | 600.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_dosing_interval_months_proxy,integer,1120,3,0.0 | 6.0 | 3.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_duration_of_PD_months_proxy,float,1120,24,0.0 | 6.2837 | 5.94321,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_serum_AGT_reduction_pct_proxy,float,1120,20,0.0 | 99.5 | 94.12331,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_systolic_BP_reduction_mmHg_proxy,float,1120,24,0.0 | 5.2747 | 10.45933,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_diastolic_BP_reduction_mmHg_proxy,float,1120,24,0.0 | 3.66768 | 3.50522,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_angII_reduction_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_aldosterone_reduction_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_hyperkalemia_pct_proxy,float,1120,24,0.0 | 3.13713 | 1.8146,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_hypotension_pct_proxy,float,1120,23,0.0 | 1.13129 | 3.02209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_eGFR_decline_event_pct_proxy,float,1120,20,0.0 | 0.52718 | 2.75901,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_injection_site_reaction_pct_proxy,float,1120,24,0.0 | 0.57365 | 8.10577,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_immunogenicity_pct_proxy,float,1120,24,0.0 | 2.26563 | 3.12769,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_renal_function_monitoring_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_potassium_monitoring_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_hypovolemia_rescue_context,categorical,1120,2,not_applicable | angiotensin_II_or_norepinephrine_or_flud,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_adherence_benefit_context_score,float,1120,10,0.0 | 0.98 | 0.95822,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_prolonged_PD_score,float,1120,10,0.0 | 0.98 | 0.94946,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_systemic_RAAS_safety_monitoring_score,float,1120,24,0.0 | 0.20613 | 0.21777,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_direct_hepatotoxicity_modifier,float,1120,24,0.0 | -0.14422 | -0.11156,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,zilebesiran_context_confidence_score,float,1120,24,0.0 | 0.83034 | 0.89445,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,context_note,categorical,1120,3,No zilebesiran/AGT RAAS context modeled  | Supporting GalNAc-siRNA AGT/RAAS platfor | Supporting AGT GalNAc-siRNA RAAS context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
+zilebesiran_raas_safety.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.