diff --git "a/chemical_modifications.csv" "b/chemical_modifications.csv"
new file mode 100644--- /dev/null
+++ "b/chemical_modifications.csv"
@@ -0,0 +1,1121 @@
+modification_id,oligo_id,source_id,sugar_chemistry,backbone_class,phosphorothioate_fraction,phosphorothioate_tertile,GalNAc_conjugated,modification_pattern,modification_locations,purity,purity_source_label,characterization_method,characterization_source_label,record_origin,value_origin
+MOD_CTRL_OLIGO_NEG_VEHICLE_MOCK,CTRL_OLIGO_NEG_VEHICLE_MOCK,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,1.0,literature_grounded_generated,not_applicable,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_CTRL_OLIGO_NEG_LOW_RISK,CTRL_OLIGO_NEG_LOW_RISK,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,2prime_OMe,low_or_no_PS,0.05,low_PS,0,2prime_OMe|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.985,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,RAPIROSIRAN_SANYAL_2025,mixed,partial_PS,0.22,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.975,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_SPHEROID_TOLERATED,CTRL_OLIGO_NEG_SPHEROID_TOLERATED,LIVER_SPHEROID_SCHOLTEN_2026,mixed,partial_PS,0.18,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.972,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_HIGH_PS_HIGH_DOSE,CTRL_OLIGO_POS_HIGH_PS_HIGH_DOSE,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,2prime_MOE,high_PS,0.98,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_18,0.955,literature_grounded_generated,HPLC,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_CTRL_OLIGO_POS_HIGH_OFFTARGET,CTRL_OLIGO_POS_HIGH_OFFTARGET,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,2prime_F,partial_PS,0.25,low_PS,1,2prime_F|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_5,0.965,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,MEMO_OLIGOTOX_PHASE2_ALIGNMENT,mixed,partial_PS,0.42,medium_PS,1,mixed|medium_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_8,0.955,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_CTRL_OLIGO_POS_LNA_GAPMER_HIGH_RISK,CTRL_OLIGO_POS_LNA_GAPMER_HIGH_RISK,RO7239958_GERETTI_2025,LNA,high_PS,0.96,high_PS,1,LNA|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_17,0.952,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_TARGETED_LNP_ASGPR,CTRL_OLIGO_NEG_TARGETED_LNP_ASGPR,MOHAMED_NANOPARTICLE_HEPATITIS_2026,2prime_OMe,partial_PS,0.12,low_PS,0,2prime_OMe|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.982,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_DELIVERY_NP_STRESS,CTRL_OLIGO_POS_DELIVERY_NP_STRESS,MOHAMED_NANOPARTICLE_HEPATITIS_2026,2prime_F,partial_PS,0.3,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_6,0.948,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_BALANCED_HYBRID_RNA_LNP,CTRL_OLIGO_NEG_BALANCED_HYBRID_RNA_LNP,MENG_HYBRID_RNA_LNP_HCC_2025,2prime_OMe,partial_PS,0.18,low_PS,0,2prime_OMe|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_4,0.976,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_IMMUNE_ACTIVATING_RNA_LNP_STRESS,CTRL_OLIGO_POS_IMMUNE_ACTIVATING_RNA_LNP_STRESS,MENG_HYBRID_RNA_LNP_HCC_2025,2prime_F,partial_PS,0.34,medium_PS,0,2prime_F|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_7,0.958,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_APOB_ASO_LOW_LIPID_STRESS,CTRL_OLIGO_NEG_APOB_ASO_LOW_LIPID_STRESS,CHEN_OVARIAN_MTTP_APOB_MIPOMERSEN_2025,2prime_MOE,partial_PS,0.32,low_PS,0,2prime_MOE|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_6,0.978,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_APOB_ASO_LIPID_EXPORT_STRESS,CTRL_OLIGO_POS_APOB_ASO_LIPID_EXPORT_STRESS,CHEN_OVARIAN_MTTP_APOB_MIPOMERSEN_2025,2prime_MOE,high_PS,0.78,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.955,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_SULT1B1_SIRNA_LIPID_RESCUE,CTRL_OLIGO_NEG_SULT1B1_SIRNA_LIPID_RESCUE,LU_SULT1B1_SE_MASLD_2026,2prime_OMe,partial_PS,0.14,low_PS,0,2prime_OMe|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_3,0.976,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_MASLD_EPIGENETIC_LIPID_ACCUMULATION,CTRL_OLIGO_POS_MASLD_EPIGENETIC_LIPID_ACCUMULATION,LU_SULT1B1_SE_MASLD_2026,2prime_F,partial_PS,0.28,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_6,0.956,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,2prime_OMe,partial_PS,0.16,low_PS,1,2prime_OMe|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_3,0.978,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_ANGPTL3_ASO_HEPATIC_FAT_ALT_SIGNAL,CTRL_OLIGO_POS_ANGPTL3_ASO_HEPATIC_FAT_ALT_SIGNAL,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,LNA,high_PS,0.88,high_PS,1,LNA|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_17,0.955,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,CTRL_OLIGO_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS,PNPLA3_ROMEO_VALENTI_2025,mixed,partial_PS,0.24,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_5,0.974,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,CTRL_OLIGO_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE,PNPLA3_ROMEO_VALENTI_2025,mixed,partial_PS,0.18,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.981,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_PNPLA3_HETEROZYGOUS_UNCERTAIN_RESPONSE,CTRL_OLIGO_CONTEXT_PNPLA3_HETEROZYGOUS_UNCERTAIN_RESPONSE,PNPLA3_ROMEO_VALENTI_2025,mixed,partial_PS,0.52,medium_PS,1,mixed|medium_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_10,0.972,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_CHOLESTEROL_SIRNA_MUSCLE_TOLERATED,CTRL_OLIGO_NEG_CHOLESTEROL_SIRNA_MUSCLE_TOLERATED,ENGELBEEN_ALK4_MUSCLE_SIRNA_2023,mixed,partial_PS,0.12,low_PS,0,mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.978,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_EXTRAHEPATIC_SIRNA_LIVER_EXPOSURE,CTRL_OLIGO_CONTEXT_EXTRAHEPATIC_SIRNA_LIVER_EXPOSURE,ENGELBEEN_ALK4_MUSCLE_SIRNA_2023,mixed,partial_PS,0.12,low_PS,0,mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.978,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_PERSONALIZED_ASO_ACCEPTABLE_SAFETY,CTRL_OLIGO_NEG_PERSONALIZED_ASO_ACCEPTABLE_SAFETY,KIM_MILASEN_CUSTOM_ASO_2019,2prime_MOE,high_PS,1.0,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_21,0.985,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_CUSTOM_ASO_TOX_WORKFLOW,CTRL_OLIGO_CONTEXT_CUSTOM_ASO_TOX_WORKFLOW,KIM_MILASEN_CUSTOM_ASO_2019,2prime_MOE,high_PS,1.0,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_21,0.985,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_GALNAC_ASO_NAFLD_TARGETED,CTRL_OLIGO_NEG_GALNAC_ASO_NAFLD_TARGETED,KEATING_ASO_OBESITY_NAFLD_2022,2prime_MOE,partial_PS,0.42,medium_PS,1,2prime_MOE|medium_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_8,0.982,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_HIGH_AFFINITY_GAPMER_SEQUENCE_MOTIF,CTRL_OLIGO_POS_HIGH_AFFINITY_GAPMER_SEQUENCE_MOTIF,KEATING_ASO_OBESITY_NAFLD_2022,LNA,high_PS,0.98,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_18,0.95,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_ASO_TYPE_I_IFN_OFFTARGET,CTRL_OLIGO_CONTEXT_ASO_TYPE_I_IFN_OFFTARGET,KEATING_ASO_OBESITY_NAFLD_2022,2prime_MOE,high_PS,0.78,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_14,0.97,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_LNA_GAPMER_SEQUENCE_REDESIGN_LOW_TOX,CTRL_OLIGO_NEG_LNA_GAPMER_SEQUENCE_REDESIGN_LOW_TOX,HAGEDORN_LNA_HEPATOTOX_RF_2013,LNA,high_PS,0.9,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_11,0.91,inferred_from_paper,ion_exchange_HPLC_LC_MS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_LNA_GAPMER_SEQUENCE_PATTERN_HIGH_TOX,CTRL_OLIGO_POS_LNA_GAPMER_SEQUENCE_PATTERN_HIGH_TOX,HAGEDORN_LNA_HEPATOTOX_RF_2013,LNA,high_PS,0.98,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_14,0.88,inferred_from_paper,ion_exchange_HPLC_LC_MS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_DISTANCE_LIMITED_SEQUENCE_TOX_PREDICTION,CTRL_OLIGO_CONTEXT_DISTANCE_LIMITED_SEQUENCE_TOX_PREDICTION,HAGEDORN_LNA_HEPATOTOX_RF_2013,LNA,high_PS,0.88,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_13,0.9,inferred_from_paper,ion_exchange_HPLC_LC_MS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_VIR2218_ESCPLUS_LOW_ALT,CTRL_OLIGO_NEG_VIR2218_ESCPLUS_LOW_ALT,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,mixed_ESCplus_GNA_seed,partial_PS,0.22,low_PS,1,mixed_ESCplus_GNA_seed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.978,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_ALNHBV_SEED_OFFTARGET_ALT,CTRL_OLIGO_POS_ALNHBV_SEED_OFFTARGET_ALT,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,mixed_ESC_parent,partial_PS,0.28,low_PS,1,mixed_ESC_parent|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_6,0.972,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,CTRL_OLIGO_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION,GANE_VIR2218_ALNHBV_HBV_RNAI_2023,mixed_ESCplus_GNA_seed,partial_PS,0.22,low_PS,1,mixed_ESCplus_GNA_seed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.978,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_ZILEBESIRAN_GALNAC_AGT_PLATFORM,CTRL_OLIGO_NEG_ZILEBESIRAN_GALNAC_AGT_PLATFORM,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,mixed,partial_PS,0.18,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.975,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_ZILEBESIRAN_RAAS_MONITORING,CTRL_OLIGO_CONTEXT_ZILEBESIRAN_RAAS_MONITORING,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,mixed,partial_PS,0.18,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.975,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_ZILEBESIRAN_LONG_PD_DEPOT,CTRL_OLIGO_CONTEXT_ZILEBESIRAN_LONG_PD_DEPOT,DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025,mixed,partial_PS,0.16,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_3,0.975,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,CTRL_OLIGO_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,2OMe_2F_alternating,partial_PS,0.18,low_PS,1,2OMe_2F_alternating|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_3,0.92,inferred_from_paper,native_IP_RP_LCMS_melting_curve_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_TERMINAL_BULGE_OFFTARGET_REPRESSION_RISK,CTRL_OLIGO_POS_TERMINAL_BULGE_OFFTARGET_REPRESSION_RISK,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,2OMe_2F_alternating,partial_PS,0.12,low_PS,0,2OMe_2F_alternating|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.91,inferred_from_paper,reporter_repression_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_SEED_REGION_BULGE_ACTIVITY_LOSS,CTRL_OLIGO_CONTEXT_SEED_REGION_BULGE_ACTIVITY_LOSS,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,2OMe_2F_alternating,partial_PS,0.12,low_PS,0,2OMe_2F_alternating|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.91,inferred_from_paper,qRT_PCR_activity_screen_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_FBLL1_HIGH_HCC_MALIGNANT_STATE,CTRL_OLIGO_CONTEXT_FBLL1_HIGH_HCC_MALIGNANT_STATE,XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,bulk_RNAseq_scRNAseq_spatial_transcriptomics_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_FBLL1_SIRNA_KNOCKDOWN_HCC_GROWTH_SUPPRESSION,CTRL_OLIGO_NEG_FBLL1_SIRNA_KNOCKDOWN_HCC_GROWTH_SUPPRESSION,XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,unmodified_or_research_siRNA_proxy,low_or_no_PS,0.0,low_PS,0,unmodified_or_research_siRNA_proxy|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.9,inferred_from_paper,qRT_PCR_CCK8_colony_formation_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_FBLL1_CMYC_EGFR_MAPK_ACTIVATION,CTRL_OLIGO_CONTEXT_FBLL1_CMYC_EGFR_MAPK_ACTIVATION,XIE_FBLL1_HCC_SPATIAL_MULTIOMICS_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,RNAseq_qPCR_Western_blot_xenograft_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_GALNAC_LNP_SIMKK4_BIOCOMPATIBLE_LOW_HEMOLYSIS,CTRL_OLIGO_NEG_GALNAC_LNP_SIMKK4_BIOCOMPATIBLE_LOW_HEMOLYSIS,ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,synthetic_siRNA_payload_proxy,low_or_no_PS,0.0,low_PS,1,synthetic_siRNA_payload_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_0,0.92,inferred_from_paper,qRT_PCR_flow_CLSM_hemolysis_live_dead_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_GALNAC_LNP_SIMKK4_ACLF_REGENERATION,CTRL_OLIGO_CONTEXT_GALNAC_LNP_SIMKK4_ACLF_REGENERATION,ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,synthetic_siRNA_payload_proxy,low_or_no_PS,0.0,low_PS,1,synthetic_siRNA_payload_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_0,0.9,inferred_from_paper,MicroCT_H_E_Ki67_TUNEL_biochemistry_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_CCL4_PHX_ACLF_INJURY_CONTEXT,CTRL_OLIGO_POS_CCL4_PHX_ACLF_INJURY_CONTEXT,ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,liver_injury_model_context_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_POS_OGT_SEV_LSEC_CAPILLARIZATION_MASLD,CTRL_OLIGO_POS_OGT_SEV_LSEC_CAPILLARIZATION_MASLD,WANG_OGT_SEV_LSEC_MASLD_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,SEM_NTA_TEM_Western_ELISA_qPCR_IHC_SERUM_ALT_AST_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_NEG_OGT_KNOCKDOWN_SEV_REDUCED_CAPILLARIZATION,CTRL_OLIGO_NEG_OGT_KNOCKDOWN_SEV_REDUCED_CAPILLARIZATION,WANG_OGT_SEV_LSEC_MASLD_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,OGT_knockdown_SEM_Western_ELISA_ALT_AST_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_OLIGO_CONTEXT_BAGN_OGLCNAC_INHIBITOR_MASLD_RESCUE,CTRL_OLIGO_CONTEXT_BAGN_OGLCNAC_INHIBITOR_MASLD_RESCUE,WANG_OGT_SEV_LSEC_MASLD_2026,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,0.0,inferred_from_paper,Western_IF_SEM_ALT_AST_TG_inflammation_OilRed_Sirius_alphaSMA_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MALAT1_001,CTRL_MALAT1_001,DU_MALAT1_HBV_HCC_ASO_2025,ASO_proxy,partial_PS,0.65,medium_PS,0,ASO_proxy|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.91,inferred_from_paper,FISH_qRT_PCR_MeRIP_RIP_RNA_pulldown_ASO_intervention_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MALAT1_002,CTRL_MALAT1_002,DU_MALAT1_HBV_HCC_ASO_2025,ASO_proxy,partial_PS,0.65,medium_PS,0,ASO_proxy|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.91,inferred_from_paper,FISH_qRT_PCR_MeRIP_RIP_RNA_pulldown_ASO_intervention_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MALAT1_003,CTRL_MALAT1_003,DU_MALAT1_HBV_HCC_ASO_2025,ASO_proxy,partial_PS,0.65,medium_PS,0,ASO_proxy|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.91,inferred_from_paper,FISH_qRT_PCR_MeRIP_RIP_RNA_pulldown_ASO_intervention_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_CD133_001,CTRL_CD133_001,PAN_CD133_MASLD_HCC_SIRNA_2025,2prime_OMe_pyrimidine_modified_siRNA_proxy,partial_PS,0.18,low_PS,0,2prime_OMe_pyrimidine_modified_siRNA_proxy|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,lineage_tracing_scRNAseq_WB_IF_VNP_siRNA_combination_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_CD133_002,CTRL_CD133_002,PAN_CD133_MASLD_HCC_SIRNA_2025,2prime_OMe_pyrimidine_modified_siRNA_proxy,partial_PS,0.18,low_PS,0,2prime_OMe_pyrimidine_modified_siRNA_proxy|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,lineage_tracing_scRNAseq_WB_IF_VNP_siRNA_combination_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_CD133_003,CTRL_CD133_003,PAN_CD133_MASLD_HCC_SIRNA_2025,2prime_OMe_pyrimidine_modified_siRNA_proxy,partial_PS,0.18,low_PS,0,2prime_OMe_pyrimidine_modified_siRNA_proxy|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,lineage_tracing_scRNAseq_WB_IF_VNP_siRNA_combination_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_GALNAC_RBC_EV_001,CTRL_GALNAC_RBC_EV_001,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,cholesterol_GalNAc_tethered_ASO_siRNA_proxy,partial_PS,0.2,low_PS,1,cholesterol_GalNAc_tethered_ASO_siRNA_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,TEM_NTA_WB_flow_IVIS_ALT_AST_histology_WB_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_GALNAC_RBC_EV_002,CTRL_GALNAC_RBC_EV_002,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,cholesterol_GalNAc_tethered_ASO_siRNA_proxy,partial_PS,0.2,low_PS,1,cholesterol_GalNAc_tethered_ASO_siRNA_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,TEM_NTA_WB_flow_IVIS_ALT_AST_histology_WB_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_GALNAC_RBC_EV_003,CTRL_GALNAC_RBC_EV_003,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,cholesterol_GalNAc_tethered_ASO_siRNA_proxy,partial_PS,0.2,low_PS,1,cholesterol_GalNAc_tethered_ASO_siRNA_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,TEM_NTA_WB_flow_IVIS_ALT_AST_histology_WB_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_GALNAC_RBC_EV_004,CTRL_GALNAC_RBC_EV_004,HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,cholesterol_GalNAc_tethered_ASO_siRNA_proxy,partial_PS,0.2,low_PS,1,cholesterol_GalNAc_tethered_ASO_siRNA_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.93,inferred_from_paper,TEM_NTA_WB_flow_IVIS_ALT_AST_histology_WB_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MELDPLUS_001,CTRL_MELDPLUS_001,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,not_applicable_clinical_risk_score_context,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,1.0,inferred_from_paper,EMR_structured_variables_logistic_regression_AUROC_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MELDPLUS_002,CTRL_MELDPLUS_002,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,not_applicable_clinical_risk_score_context,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,1.0,inferred_from_paper,EMR_structured_variables_logistic_regression_AUROC_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_CTRL_MELDPLUS_003,CTRL_MELDPLUS_003,KARTOUN_MELD_PLUS_CIRRHOSIS_2017,not_applicable_clinical_risk_score_context,low_or_no_PS,0.0,low_PS,0,not_applicable,not_applicable,1.0,inferred_from_paper,EMR_structured_variables_logistic_regression_AUROC_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000000,OLIGO_0000000,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOTOX_2018,2prime_F,high_PS,0.7389,high_PS,0,2prime_F|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_18,0.96611,literature_grounded_generated,not_reported_generated,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000001,OLIGO_0000001,RAPIROSIRAN_SANYAL_2025,AmNA,low_or_no_PS,0.04775,low_PS,1,AmNA|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_1,0.98067,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000002,OLIGO_0000002,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,LNA,low_or_no_PS,0.04378,low_PS,1,LNA|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_1,0.9427,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000003,OLIGO_0000003,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,mixed,partial_PS,0.4101,medium_PS,0,mixed|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_8,0.95745,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000004,OLIGO_0000004,RAPIROSIRAN_SANYAL_2025,2prime_F,partial_PS,0.05867,low_PS,1,2prime_F|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_1,0.94384,inferred_from_paper,HPLC,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000005,OLIGO_0000005,HAUPTMANN_SIRNA_BULGES_GALNAC_2022,2OMe_2F_alternating,partial_PS,0.15482,low_PS,0,2OMe_2F_alternating|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_3,0.92561,inferred_from_paper,qRT_PCR_ELISA_reporter_melting_LCMS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000006,OLIGO_0000006,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2025,2prime_F,partial_PS,0.0827,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.99215,literature_grounded_generated,not_reported_generated,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000007,OLIGO_0000007,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,cEt,partial_PS,0.28455,low_PS,0,cEt|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_6,0.999,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000008,OLIGO_0000008,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_2018,2prime_F,partial_PS,0.09607,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.93447,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000009,OLIGO_0000009,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_2018,mixed,partial_PS,0.08957,low_PS,0,mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.97042,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000010,OLIGO_0000010,BI_IFNA_DISULFIDPTOSIS_HCC_2026,LNA,partial_PS,0.06829,low_PS,0,LNA|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.98965,literature_grounded_generated,IFN_alpha_disulfidptosis_context_nonreducing_WB_NADPH_Factin_siRNA_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000011,OLIGO_0000011,HJELMGREN_PS_ASO_DDR_2026,RNA_PS,high_PS,0.7,high_PS,1,RNA_PS|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_17,0.97848,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000012,OLIGO_0000012,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,mixed,partial_PS,0.53889,medium_PS,1,mixed|medium_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_10,0.96865,literature_grounded_generated,mass_spectrometry,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000014,OLIGO_0000014,HAGEDORN_LNA_HEPATOTOX_RF_2013,LNA,high_PS,0.90363,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_14,0.9159,inferred_from_paper,ion_exchange_HPLC_LC_MS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000015,OLIGO_0000015,LU_SULT1B1_SE_MASLD_2026,2prime_OMe,partial_PS,0.30531,low_PS,0,2prime_OMe|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_9,0.97575,inferred_from_paper,HPLC+LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000016,OLIGO_0000016,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,mixed,partial_PS,0.23019,low_PS,0,mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_6,0.99304,literature_grounded_generated,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000019,OLIGO_0000019,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,2prime_MOE,partial_PS,0.15271,low_PS,0,2prime_MOE|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_3,0.96902,literature_grounded_generated,mass_spectrometry,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000020,OLIGO_0000020,OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023,2prime_MOE,high_PS,0.86272,high_PS,1,2prime_MOE|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_20,0.91928,inferred_from_paper,LC-MS,inferred_from_paper,dbbun_generated,inferred_from_paper
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+MOD_OLIGO_0000022,OLIGO_0000022,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,mixed,high_PS,0.73744,high_PS,0,mixed|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_18,0.92775,literature_grounded_generated,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000024,OLIGO_0000024,KIM_NANP_LIPID_LIVER_TARGETING_2026,unmodified,partial_PS,0.11394,low_PS,1,unmodified|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_3,0.93866,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000026,OLIGO_0000026,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,2prime_F,partial_PS,0.17276,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_3,0.96736,literature_grounded_generated,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000027,OLIGO_0000027,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,LNA,high_PS,0.83682,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_18,0.91756,literature_grounded_generated,HPLC,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000459,OLIGO_0000459,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,not_applicable_sEV_payload_context,low_or_no_PS,0.0,low_PS,0,not_applicable_sEV_payload_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.94763,literature_grounded_generated,RT_qPCR_NTA_TEM_Western_RNase_protection_IVIS_ALT_AST_H_E_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000460,OLIGO_0000460,ALSHAER_FDA_TIDES_HARVEST_2025,2prime_MOE,low_or_no_PS,0.03093,low_PS,1,2prime_MOE|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_1,0.999,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000461,OLIGO_0000461,HJELMGREN_PS_ASO_DDR_2026,LNA_mixed,high_PS,0.7,high_PS,1,LNA_mixed|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_10,0.93554,literature_grounded_generated,HPLC,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000510,OLIGO_0000510,BUREL_GAPMER_RNASEH1_LONG_PREMRNA_HEPATOTOX_2016,AmNA,partial_PS,0.37133,medium_PS,0,AmNA|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_8,0.93366,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000515,OLIGO_0000515,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,mixed,high_PS,0.73442,high_PS,1,mixed|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_15,0.9624,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000517,OLIGO_0000517,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,mixed,partial_PS,0.20379,low_PS,0,mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_4,0.98317,literature_grounded_generated,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000518,OLIGO_0000518,LIU_CYP2E1_LNP_APAP_AILI_2025,2prime_OMe,high_PS,0.69211,high_PS,0,2prime_OMe|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.98647,literature_grounded_generated,HPLC+LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000521,OLIGO_0000521,HJELMGREN_PS_ASO_DDR_2026,2prime_MOE,high_PS,0.7,high_PS,0,2prime_MOE|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.98441,literature_grounded_generated,HPLC,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000531,OLIGO_0000531,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,cEt,low_or_no_PS,0.03243,low_PS,0,cEt|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.94942,literature_grounded_generated,LC-MS,literature_grounded_generated,dbbun_generated,literature_grounded_generated
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+MOD_OLIGO_0000995,OLIGO_0000995,LIU_CYP2E1_LNP_APAP_AILI_2025,LNA,high_PS,0.78536,high_PS,1,LNA|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_13,0.96647,literature_grounded_generated,not_reported_generated,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000996,OLIGO_0000996,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,mixed,partial_PS,0.31168,low_PS,1,mixed|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_7,0.9741,literature_grounded_generated,mass_spectrometry,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000997,OLIGO_0000997,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,2prime_F,low_or_no_PS,0.02893,low_PS,0,2prime_F|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.90652,literature_grounded_generated,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated,dbbun_generated,literature_grounded_generated
+MOD_OLIGO_0000998,OLIGO_0000998,HAGEDORN_LNA_HEPATOTOX_RF_2013,LNA,high_PS,0.91754,high_PS,0,LNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_11,0.89585,inferred_from_paper,ion_exchange_HPLC_LC_MS_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_0000999,OLIGO_0000999,ZHAI_GALNAC_LNP_SIMKK4_LIVER_REGEN_2026,synthetic_siRNA_payload_proxy,low_or_no_PS,0.0,low_PS,1,synthetic_siRNA_payload_proxy|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_0,0.91923,inferred_from_paper,MTT_colony_Ki67_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS,OLIGO_CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS,MA_FORMONONETIN_ALDH2_ALD_2025,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION,OLIGO_CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION,MA_FORMONONETIN_ALDH2_ALD_2025,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE,OLIGO_CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE,MA_FORMONONETIN_ALDH2_ALD_2025,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL,OLIGO_CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTREATMENT,OLIGO_CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTREATMENT,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOSOMAL_ESCAPE,OLIGO_CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOSOMAL_ESCAPE,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,2prime_OMe_2prime_F_mixed,low_or_no_PS,0.05,low_PS,0,2prime_OMe_2prime_F_mixed|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_1,0.95,literature_grounded_generated_control,literature_context_control,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_TOX,OLIGO_CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_TOX,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,not_applicable_sEV_payload_context,low_or_no_PS,0.0,low_PS,0,not_applicable_sEV_payload_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.95,literature_grounded_generated_control,RT_qPCR_NTA_TEM_Western_RNase_protection_IVIS_ALT_AST_H_E_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_LOADING,OLIGO_CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_LOADING,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,not_applicable_sEV_payload_context,low_or_no_PS,0.0,low_PS,0,not_applicable_sEV_payload_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.95,literature_grounded_generated_control,RT_qPCR_NTA_TEM_Western_RNase_protection_IVIS_ALT_AST_H_E_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_PMEVL_ERK_AMPK_ANXA2_ESCRT_MECHANISM,OLIGO_CTRL_CONTEXT_PMEVL_ERK_AMPK_ANXA2_ESCRT_MECHANISM,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,not_applicable_sEV_payload_context,low_or_no_PS,0.0,low_PS,0,not_applicable_sEV_payload_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.95,literature_grounded_generated_control,RT_qPCR_NTA_TEM_Western_RNase_protection_IVIS_ALT_AST_H_E_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FRAMEWORK,OLIGO_CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FRAMEWORK,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,MOE_or_mixed_OND_context,partial_PS,0.65,medium_PS,0,MOE_or_mixed_OND_context|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.96,literature_grounded_generated_control,preclinical_safety_screening_cascade_ALT_AST_kidney_complement_platelet_offtarget_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK,OLIGO_CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,LNA_cEt_high_affinity,high_PS,1.0,high_PS,0,LNA_cEt_high_affinity|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.96,literature_grounded_generated_control,preclinical_safety_screening_cascade_ALT_AST_kidney_complement_platelet_offtarget_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_HYBRIDIZATION_OFFTARGET_SCREENING,OLIGO_CTRL_CONTEXT_HYBRIDIZATION_OFFTARGET_SCREENING,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,MOE_or_mixed_OND_context,partial_PS,0.65,medium_PS,0,MOE_or_mixed_OND_context|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.96,literature_grounded_generated_control,preclinical_safety_screening_cascade_ALT_AST_kidney_complement_platelet_offtarget_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_PRODUCTIVE_UPTAKE_HEPATOCYTE,OLIGO_CTRL_CONTEXT_GALNAC_PRODUCTIVE_UPTAKE_HEPATOCYTE,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,2OMe_2F_stabilized,partial_PS,0.25,low_PS,1,2OMe_2F_stabilized|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_5,0.96,literature_grounded_generated_control,preclinical_safety_screening_cascade_ALT_AST_kidney_complement_platelet_offtarget_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_CMAX_COMPLEMENT_COAGULATION_MONITORING,OLIGO_CTRL_CONTEXT_CMAX_COMPLEMENT_COAGULATION_MONITORING,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,MOE_or_mixed_OND_context,partial_PS,0.65,medium_PS,0,MOE_or_mixed_OND_context|medium_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_12,0.96,literature_grounded_generated_control,preclinical_safety_screening_cascade_ALT_AST_kidney_complement_platelet_offtarget_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_POS_IFNA_DISULFIDPTOSIS_HCC,OLIGO_CTRL_POS_IFNA_DISULFIDPTOSIS_HCC,BI_IFNA_DISULFIDPTOSIS_HCC_2026,unmodified_or_contextual,low_or_no_PS,0.0,low_PS,0,unmodified_or_contextual|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.97,literature_grounded_generated_control,IFN_alpha_disulfidptosis_context_nonreducing_WB_NADPH_Factin_siRNA_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE,OLIGO_CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE,BI_IFNA_DISULFIDPTOSIS_HCC_2026,unmodified_or_contextual,low_or_no_PS,0.0,low_PS,0,unmodified_or_contextual|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.97,literature_grounded_generated_control,IFN_alpha_disulfidptosis_context_nonreducing_WB_NADPH_Factin_siRNA_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_SLC7A11_KD_IFNA_AGGRAVATION,OLIGO_CTRL_CONTEXT_SLC7A11_KD_IFNA_AGGRAVATION,BI_IFNA_DISULFIDPTOSIS_HCC_2026,unmodified_or_contextual,low_or_no_PS,0.0,low_PS,0,unmodified_or_contextual|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.97,literature_grounded_generated_control,IFN_alpha_disulfidptosis_context_nonreducing_WB_NADPH_Factin_siRNA_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_IFNA_ISG_B2M_USP18_PSME1,OLIGO_CTRL_CONTEXT_IFNA_ISG_B2M_USP18_PSME1,BI_IFNA_DISULFIDPTOSIS_HCC_2026,unmodified_or_contextual,low_or_no_PS,0.0,low_PS,0,unmodified_or_contextual|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.97,literature_grounded_generated_control,IFN_alpha_disulfidptosis_context_nonreducing_WB_NADPH_Factin_siRNA_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_GALNAC_ESC_SIRNA_PLATFORM_LOW_TOX,OLIGO_CTRL_NEG_GALNAC_ESC_SIRNA_PLATFORM_LOW_TOX,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,mixed_2prime_OMe_2prime_F_ESC,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX,OLIGO_CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,mixed_2prime_OMe_2prime_F_ESC,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION,OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION,JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_2018,mixed_2prime_OMe_2prime_F_ESC,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,rat_monkey_repeat_dose_toxicology_platform_safety_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPONSE,OLIGO_CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPONSE,BOSCO_INCLISIRAN_FH_REALWORLD_2025,mixed_2prime_OMe_2prime_F_ESC,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,real_world_six_month_lipid_PWV_ALT_AST_CPK_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD,OLIGO_CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD,BOSCO_INCLISIRAN_FH_REALWORLD_2025,mixed_2prime_OMe_2prime_F_ESC,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,real_world_six_month_lipid_PWV_ALT_AST_CPK_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW,OLIGO_CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context,high_PS,0.85,high_PS,1,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_17,0.98,literature_grounded_generated_control,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY,OLIGO_CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context,high_PS,0.85,high_PS,1,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_14,0.98,literature_grounded_generated_control,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY,OLIGO_CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context,partial_PS,0.2,low_PS,1,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_4,0.98,literature_grounded_generated_control,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY,OLIGO_CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_2020,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context,high_PS,0.85,high_PS,1,mixed_2prime_OMe_2prime_F_ESC_or_MOE_gapmer_context|high_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_17,0.98,literature_grounded_generated_control,GalNAc_ASGPR_liver_delivery_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM,OLIGO_CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_2023,2prime_OMe_2prime_F_or_unmodified_context,partial_PS,0.12,low_PS,1,2prime_OMe_2prime_F_or_unmodified_context|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_2,0.98,literature_grounded_generated_control,RISC_GalNAc_PKPD_safety_clinical_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_SIRNA_PKPD_BARRIERS,OLIGO_CTRL_CONTEXT_SIRNA_PKPD_BARRIERS,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_2023,2prime_OMe_2prime_F_or_unmodified_context,low_or_no_PS,0.0,low_PS,0,2prime_OMe_2prime_F_or_unmodified_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.98,literature_grounded_generated_control,RISC_GalNAc_PKPD_safety_clinical_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCREENING,OLIGO_CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCREENING,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_2023,2prime_OMe_2prime_F_or_unmodified_context,partial_PS,0.12,low_PS,0,2prime_OMe_2prime_F_or_unmodified_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_2,0.98,literature_grounded_generated_control,RISC_GalNAc_PKPD_safety_clinical_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION,OLIGO_CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_2023,2prime_OMe_2prime_F_or_unmodified_context,partial_PS,0.12,low_PS,1,2prime_OMe_2prime_F_or_unmodified_context|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_2,0.98,literature_grounded_generated_control,RISC_GalNAc_PKPD_safety_clinical_review_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,OLIGO_CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_13,0.98,literature_grounded_generated_control,ALT_AST_liver_weight_RNAseq_OTE_selectivity_screen_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX,OLIGO_CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_liver_weight_RNAseq_OTE_selectivity_screen_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN,OLIGO_CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_liver_weight_RNAseq_OTE_selectivity_screen_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY,OLIGO_CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY,KAMOLA_ASO_HEPATOTOX_SCREEN_2017,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_13,0.98,literature_grounded_generated_control,ALT_AST_liver_weight_RNAseq_OTE_selectivity_screen_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_lipid_profile_liver_histology_inflammatory_gene_expression_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_lipid_profile_liver_histology_inflammatory_gene_expression_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_lipid_profile_liver_histology_inflammatory_gene_expression_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,OLIGO_CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,LNA_gapmer_wings_context,high_PS,1.0,high_PS,0,LNA_gapmer_wings_context|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,ALT_AST_lipid_profile_liver_histology_inflammatory_gene_expression_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION,OLIGO_CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,2prime_constrained_ethyl_cEt,high_PS,1.0,high_PS,0,2prime_constrained_ethyl_cEt|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,systemic_ASO_tolerability_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE,OLIGO_CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,2prime_constrained_ethyl_cEt,high_PS,1.0,high_PS,0,2prime_constrained_ethyl_cEt|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,systemic_ASO_tolerability_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION,OLIGO_CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,2prime_constrained_ethyl_cEt,high_PS,1.0,high_PS,0,2prime_constrained_ethyl_cEt|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,systemic_ASO_tolerability_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_GYS1_GYS2_ISOFORM_SPECIFICITY,OLIGO_CTRL_CONTEXT_GYS1_GYS2_ISOFORM_SPECIFICITY,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,2prime_constrained_ethyl_cEt,high_PS,1.0,high_PS,0,2prime_constrained_ethyl_cEt|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_15,0.98,literature_grounded_generated_control,systemic_ASO_tolerability_monitoring_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_ALT_ALP_BILI,OLIGO_CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_ALT_ALP_BILI,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.98,literature_grounded_generated_control,cholestasis_cholangiocyte_context_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLUTION,OLIGO_CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLUTION,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.98,literature_grounded_generated_control,cholestasis_cholangiocyte_context_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_CX3CL1_CX3CR1_MACROPHAGE_RECRUITMENT,OLIGO_CTRL_CONTEXT_CX3CL1_CX3CR1_MACROPHAGE_RECRUITMENT,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,not_applicable,low_or_no_PS,0.0,low_PS,0,not_applicable|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.98,literature_grounded_generated_control,cholestasis_cholangiocyte_context_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_CONTEXT_NFYA_TGFB1_CHOLANGIOCYTE_FIBROSIS,OLIGO_CTRL_CONTEXT_NFYA_TGFB1_CHOLANGIOCYTE_FIBROSIS,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,unmodified_siRNA_context,low_or_no_PS,0.0,low_PS,0,unmodified_siRNA_context|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.98,literature_grounded_generated_control,cholestasis_cholangiocyte_context_generated_proxy,literature_grounded_generated_control,dbbun_generated,literature_grounded_generated_control
+MOD_OLIGO_CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBLE_LIVER_SIGNAL,OLIGO_CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBLE_LIVER_SIGNAL,KANDA_PCDHA11_AMNA_ASO_2024,AmNA,high_PS,1.0,high_PS,0,AmNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.98113,inferred_from_paper,AmNA_ASO_synthesis_HPLC_LCMS_qPCR_microarray_toxicology_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET_LIVER_SIGNAL,OLIGO_CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET_LIVER_SIGNAL,KANDA_PCDHA11_AMNA_ASO_2024,AmNA,high_PS,1.0,high_PS,0,AmNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.9739,inferred_from_paper,AmNA_ASO_synthesis_HPLC_LCMS_qPCR_microarray_toxicology_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_POS_PCDHA11_AMNA_3969_SEQUENCE_DEPENDENT_LIVER_INJURY,OLIGO_CTRL_POS_PCDHA11_AMNA_3969_SEQUENCE_DEPENDENT_LIVER_INJURY,KANDA_PCDHA11_AMNA_ASO_2024,AmNA,high_PS,1.0,high_PS,0,AmNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.98463,inferred_from_paper,AmNA_ASO_synthesis_HPLC_LCMS_qPCR_microarray_toxicology_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_CONTEXT_PCDHA11_AMNA_OFFTARGET_MICROARRAY_SCREEN,OLIGO_CTRL_CONTEXT_PCDHA11_AMNA_OFFTARGET_MICROARRAY_SCREEN,KANDA_PCDHA11_AMNA_ASO_2024,AmNA,high_PS,1.0,high_PS,0,AmNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.98033,inferred_from_paper,AmNA_ASO_synthesis_HPLC_LCMS_qPCR_microarray_toxicology_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_CONTEXT_PCDHA11_KO_TARGET_SPECIFICITY_APOPTOSIS,OLIGO_CTRL_CONTEXT_PCDHA11_KO_TARGET_SPECIFICITY_APOPTOSIS,KANDA_PCDHA11_AMNA_ASO_2024,AmNA,high_PS,1.0,high_PS,0,AmNA|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.96625,inferred_from_paper,AmNA_ASO_synthesis_HPLC_LCMS_qPCR_microarray_toxicology_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE,OLIGO_CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE,HJELMGREN_PS_ASO_DDR_2026,DNA_PS,high_PS,0.95,high_PS,0,DNA_PS|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_17,0.97,inferred_from_paper,fluorescent_ASO_imaging_Western_blot_pull_down_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY,OLIGO_CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY,HJELMGREN_PS_ASO_DDR_2026,DNA_or_RNA_PO_backbone_contrast,low_or_no_PS,0.0,low_PS,0,DNA_or_RNA_PO_backbone_contrast|low_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_0,0.97,inferred_from_paper,fluorescent_ASO_imaging_Western_blot_pull_down_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_CONTEXT_ASO_REPAIR_PROTEIN_BINDING,OLIGO_CTRL_CONTEXT_ASO_REPAIR_PROTEIN_BINDING,HJELMGREN_PS_ASO_DDR_2026,mixed_LNA_DNA_gapmer,high_PS,0.9,high_PS,0,mixed_LNA_DNA_gapmer|high_PS|GalNAc=0,generated_terminal_and_internal_pattern_PS_count_16,0.97,inferred_from_paper,fluorescent_ASO_imaging_Western_blot_pull_down_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNCTION_IMPROVED,OLIGO_CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNCTION_IMPROVED,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,mixed_2prime_F_2prime_OMe_siRNA,partial_PS,0.28,low_PS,1,mixed_2prime_F_2prime_OMe_siRNA|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_6,0.97,inferred_from_paper,nanoparticle_DLS_zeta_biodistribution_Rubicon_knockdown_ALT_AST_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGETING,OLIGO_CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGETING,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,mixed_2prime_F_2prime_OMe_siRNA,partial_PS,0.28,low_PS,1,mixed_2prime_F_2prime_OMe_siRNA|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_6,0.97,inferred_from_paper,nanoparticle_DLS_zeta_biodistribution_Rubicon_knockdown_ALT_AST_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper
+MOD_OLIGO_CTRL_CONTEXT_PEI_NANOCARRIER_SAFETY_MONITORING,OLIGO_CTRL_CONTEXT_PEI_NANOCARRIER_SAFETY_MONITORING,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,mixed_2prime_F_2prime_OMe_siRNA,partial_PS,0.28,low_PS,1,mixed_2prime_F_2prime_OMe_siRNA|low_PS|GalNAc=1,generated_terminal_and_internal_pattern_PS_count_6,0.97,inferred_from_paper,nanoparticle_DLS_zeta_biodistribution_Rubicon_knockdown_ALT_AST_generated_proxy,inferred_from_paper,dbbun_generated,inferred_from_paper