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1. Introduction {#sec1}
===============
Alternative splicing is a fundamental cellular process by which a multiexon gene generates different transcripts from the same primary sequence, thereby increasing functional diversity of the expressed genome. The central dogma of "one gene, one mRNA, and one protein" is outmode... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
Microbial Biotechnology (2020) 13(4), 974--983
**Funding Information**
We greatly acknowledge the financial support from NSFC (21878155), PAPD, Qing Lan Project of Jiangsu Universities, the Six Talent Peaks Project in Jiangsu Province and the Jiangsu Synergetic Innovation Center for Advanced Bio‐Manufacture.
Introdu... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The gut endocrine system is a rich source of peptides with therapeutic potential^[@CR1]--[@CR3]^. The demonstrated involvement of altered gut hormone profiles in both the success of bariatric surgery and the treatment of metabolic disorders implies that greater understanding and infor... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Coronary artery disease (CAD) is one of the greatest threats to human health and life, and it usually occurs when cholesterol builds up inside the walls of arteries, eventually forming a plaque, thus narrowing the arteries and limiting the flow of oxygen-rich blood to the heart. At pres... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Sacoglossa sea slugs are a relatively small group of heterobranch gastropods with currently about 300 species described \[[@B1]\], comprising the shelled Oxynoacea and the shell-less Plakobranchacea. The latter is further divided into the ceras-bearing Limapontioidea (although not monophyletic in... | {
"pile_set_name": "PubMed Central"
} |
1.. Human Orthopoxvirus Infections
==================================
Human orthopoxviruses cause a spectrum of diseases, ranging from severe disseminated lesional disease characteristic of the most common type of variola virus infection (variola major) to localized lesional infection caused by vaccinia virus. Of the ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Despite recent improvements, pulmonary arterial hypertension (PAH) remains a devastating disease, with most patients still harbouring markedly reduced exercise tolerance and limited survival.[@R1] [@R2] Recent randomised controlled trials (RCT) using morbidity/mortality endpoints demons... | {
"pile_set_name": "PubMed Central"
} |
In the article titled "Guidelines from the Canadian Association of Pathologists for establishing a telepathology service for anatomic pathology using whole-slide imaging", published as elocation 15, Volume 5 of Journal of Pathology Informatics \[[@ref1]\], the list of authors and affiliations is incorrectly written as
... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Emotional support is considered to be a powerful protective agent not only against depression but also against obesity (Vogelzangs et al., [@B34]; Sharpley et al., [@B31]). However, research on the relationship between emotional support and body composition is scarce and only unstandard... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The clinical success of orthopedic and dental implants depends on the interaction between the implanted surface and bone tissues and, consequently, their osseointegration \[[@B1]\]. Titanium implants are used widely in orthopedic surgery and dentistry for their favorable biocompatibility and corr... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec005}
============
Focal hyperintensities on T2 weighted spin echo or fluid-attenuated inversion recovery (FLAIR) imaging in the region of diffusion restriction on diffusion weighted imaging (DWI) have been identified as a t... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Host--guest chemistry has attracted great attention in the field of separation and/or extraction of alkaline, rare earth, and divalent heavy metal ions with calixarenes and their ester derivatives. Calixarenes have unusual capabilities to identify and distinguish between differe... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
HIV/AIDS has been a global pandemic for the last 30 years, and its spread has yet to be contained. However, due to the availability of antiretroviral therapy, today HIV is becoming a chronic disease, which means that more physicians from every medical field will encounter HIV-infected individuals... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .380}
| {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Inflammatory breast cancer (IBC) is a rare and aggressive type of locally advanced breast cancer (LABC) characterized by diffuse erythema and edema (or peau d'orange) of the breast \[[@CR1], [@CR2]\]. The IBC diagnosis is primarily clinical but also requires pathological confirmation of c... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-animals-09-00701}
===============
Taste is well-known biological descriptor for sweet, bitter, sour, salty receptors and ion channels, which plays a critical role in the life and nutritional status of chickens and other organisms. Bitter taste perception provides animals with critical protection... | {
"pile_set_name": "PubMed Central"
} |
Key Points {#FPar1}
==========
Despite their equal importance in aiding decision makers to allocate limited resources, fewer budget impact analyses are published in the literature compared with cost-effectiveness analyses.Furthermore, published budget impact analyses do not meet current best-practice recommendations s... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Among the data privacy protection technologies, existing research is based on the solution from the following perspectives: anonymity-based methods, encryption-based methods, noise-based method, and differential privacy-based method. There have been many reliable encryption-based meth... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) estimated that in 2009, 33.3 million individuals worldwide were infected with HIV \[[@B1]\]. Many live in sub-Saharan Africa, where there were an estimated 1.3 million AIDS related deaths in 2009 \[[@B... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Schizophrenia and bipolar disorders share various common characteristics so that they can be viewed in a dimensional continuum view, as opposed to a categorical dichotomous vision.\[[@ref1]\] Besides clinical features, it has been shown that they exhibit similar genetic and neurocog... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Anxiety disorders are among the most common psychiatric problems experienced by children \[[@CR1]\]. Related functional impairments can include school refusal, failure to make and keep friends, and family conflict \[[@CR2], [@CR3]\]. If left untreated, child anxiety disorders can be p... | {
"pile_set_name": "PubMed Central"
} |
Interview and discussion guidelines are available in the Supporting Information files. Additional data cannot be made publicly available due to ethical restrictions regarding participant consent to data release. Interested parties may contact Mr. Jitu Mia (<jitusust@gmail.com>), Assistant Administrative Officer, Depart... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Schizophrenia is a severe mental disorder with a worldwide prevalence of around 1%, placing significant burden on global health \[[@CR1]\]. The introduction of antipsychotic medications has improved the positive psychotic symptoms of schizophrenia patients \[[@CR2]\]. However, schizophren... | {
"pile_set_name": "PubMed Central"
} |
{.402}
| {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Amplification and overexpression of HER2 (also named ErbB2) receptor tyrosine kinase, detected in 20--30% of breast cancer, are associated with a poor clinical patient outcome, including lymph node metastasis, shorter survival, and shorter time to recurrence \[[@B1], [@B2]\]. Ac... | {
"pile_set_name": "PubMed Central"
} |
Indications for anticoagulant therapy
=====================================
Thrombosis, the formation of a blood clot within a blood vessel or cavity of the heart, is a leading cause of death and disability. Up to 15% of patients hospitalized for an acute medical illness develop venous thromboembolic disease and some ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Goat's milk, due to its unique characteristics is of particular interest to consumers and producers and can be the basis for the creation of new dairy products using enzymatic processes and membrane separation (Cais-Sokolińska et al., [@CR5]; Pikul et al., [@CR13]). For example, milk ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
RNAi and morpholino antisense studies on regulatory genes have offered crucial insights into the genetic mechanisms underlying bauplan changes in metazoan animals [@pone.0000694-Amali1]--[@pone.0000694-Momose1]. It is highly unfortunate that only a very limited number of gene silencing ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Transgenic crops with enhanced resistance to insect pests or tolerance of broad-spectrum herbicides have been commercially available for over a decade and are widely used worldwide. Insect resistance and herbicide tolerance are examples of "input traits", which improve the agronomic p... | {
"pile_set_name": "PubMed Central"
} |
Anoxia or ischemia causes an accumulation of long-chain fatty acid esters mainly because of the inhibition of B oxidation. These compounds have deleterious effects on cellular and intracellular membranes. They also inhibit mitochondrial adenine nucleotide translocase inducing inhibition of ATP within the mitochondrial ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Brucellosis, previously known as Malta fever, is one of the most common zoonotic diseases. Owing to its subtle nature, difficult diagnosis, tendency to relapse, and potentially debilitating complications, brucellosis is a major health problem in the world. Annually, more than half a million p... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Eukaryotic DNA is packaged into chromatin incorporating repeating nucleosomes by wrapping DNA around core histones (H2A, H2B, H3 and H4). In mammalian cells, the N-terminal tail of histone is subject to many chemical modifications such as methylation, acetylation, ubiquitylation, phosphorylat... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Evidence has accumulated on the association between air pollution and adverse birth outcomes, such as preterm birth or low birth weight (LBW) \[[@B1]-[@B4]\]. Indeed, recent systematic reviews and original studies have indicated positive associations between various air pollution indicators (e.g.... | {
"pile_set_name": "PubMed Central"
} |
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{#sp2 .49}
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{#sp4 .51}
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"pile_set_name": "PubMed Central"
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INTRODUCTION {#s1}
============
Bacteria living within communities do so through cooperation and antagonism. Forms of antagonism whereby one bacterium targets another are important for maintaining the stable coexistence of bacteria within microbiomes and are deployed by pathogens and commensals alike to kill competito... | {
"pile_set_name": "PubMed Central"
} |
###### Strengths and limitations of this study
- This study, the first of its kind, examines the decomposition of socioeconomic inequality in functional deficiency and chronic illness separately for older men and women.
- The findings revealed pro-poor inequality in Instrumental Activity of Daily Living (IADL) de... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Olanzapine is an atypical antipsychotic agent that is used to effectively treat symptomatic and asymptomatic schizophrenia. However, several adverse effects including tiredness, weight increase, and constipation have been reported in clinical practice. Compared to other antipsychotic agents, ... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
Improvements in the early detection and the treatment of breast cancer have greatly reduced the mortality of the disease. However, the ability of tumor cells to infiltrate their surrounding microenvironment and wreak havoc on an otherwise unc... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Head and neck cancer (HNC) is the seventh most common malignancy worldwide, and remains a serious public health problem ([@b1-ol-0-0-8185],[@b2-ol-0-0-8185]). Previous studies have demonstrated that heredity, Epstein-Barr virus infection and environmental factors serve notable roles in HNC de... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s0005}
============
The cornea, the transparent layer forming the front of the eye, covers the iris and the pupil and allows light to enter the eye.[@b0005] This transparent tissue plays a critical role in vision as it is the main refractive surface that transmits light into the retina. Multiple causes ... | {
"pile_set_name": "PubMed Central"
} |
1.. INTRODUCTION
================
Crop plants in the fields are usually subjected to one or more biotic and/or abiotic stresses which reduce agricultural output significantly, leading to a huge yield-gap. Soil salinity is one such stress which reduces agricultural output drastically. The FAO/UNESCO soil map of the wor... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
The cyclin-dependent kinase (CDK) inhibitor p21*^CDKN1A^* plays multiple roles not only as a cell-cycle regulator, but also as a regulator of transcription and apoptosis ([@B1],[@B2]). In addition, p21 interacts with proliferating cell nuclear antigen (PCNA), and inhibits DNA synthesis by dis... | {
"pile_set_name": "PubMed Central"
} |
Contract grant sponsors: Dijon University Hospital; Regional Council of Burgundy; Interdisciplinary Center for Clinical Research (IZKF) Erlangen (projects E16 and E26); German Research Foundation DFG (Zw184/1‐2); Norwegian Cancer Society; The Bergen Research Foundation BFS; Research Council of Norway (grant 230865); We... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
A major discovery in the field of aging research is that large differences in maximum lifespan can be attributed to the effects of a few major signaling pathways. The first 'aging gene\' was discovered in the nematode worm, *C. elegans*, in a genetic screen for long-lived mutants \[[@R1... | {
"pile_set_name": "PubMed Central"
} |
**Linked articles** This article is highlighted by a Perspective by Yoshino. To read this Perspective, visit <https://doi.org/10.1113/JP275576>.
Edited by: Kim Barrett & Bettina Mittendorfer
This is an Editor\'s Choice article from the 15 February 2018 issue.
Introduction {#tjp12723-sec-0030}
============
Adipose t... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
The HIV-1 (human immunodeficiency virus type 1) capsid protein, the p24 antigen (p24), has great significance for diagnostics, because it can be detected several days earlier than host-generated HIV antibodies (which are the target of almost all current tests used in the field), and can... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Every year, more than one million individuals worldwide develop colorectal cancer for which the disease-specific mortality rate is nearly 33% in the developed world ([@b1-or-31-04-1531]). Recent clinical trials of adjuvant chemotherapy following surgical resection have shown significant survi... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Benign prostatic hyperplasia (BPH) is a one of the most common chronic diseases of men worldwide.[@ref1] The high prevalence of BPH is also associated with high medical expenditures. One study reported that total medical expenditures with BPH were US\$776 million in the United State... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0001}
===============
At the end of 2019, a novel coronavirus pneumonia, COVID-19, began to rapidly propagate due to widespread person-to-person transmission [@bib0001]. By April 5th, 2020, there were over 1 million confirmed COVID-19 cases, and tens of thousands of people lost their lives. The ep... | {
"pile_set_name": "PubMed Central"
} |
During past influenza epidemics, hospital staff have been confronted with a surge of inpatients ([@R1]--[@R5]), and modeling studies predict collapse of the healthcare system if resources are not allocated carefully ([@R6],[@R7]). To ensure the availability of healthcare during a pandemic, maintaining qualified staff c... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
All drinking-water treatment plants produce water treatment residuals during the process of water purification for human consumption. These residuals mainly consist of organic and inorganic compounds in so... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
A few years ago, accidental lead (Pb^2+^) poisoning in drinking water in the city of Flint, Michigan, caused many people, especially children younger than 5 years, to suffer from skin rashes, as well as cognitive and behavioral disorders^[@CR1]^. This incident serves to demonstrate th... | {
"pile_set_name": "PubMed Central"
} |
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| {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#S1}
============
Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) are a group of clonal stem cell-derived hematologic malignancies characterized by overproduction of myeloid lineage cells. A somatic mutation (V617F) in the JAK2 tyrosine kinase was found in a majority of patients... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Rheumatologic diseases are associated with high morbidity leading to reduced quality of life, potentially life-long disability, and premature death. Although rare in individuals, as a whole group rare rheumatologic disorders afflict a large group of people \[[@CR1], [@CR2]\]. Furthermore,... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Dry eye disease (DED) is a common disorder that affects millions of patients^[@CR1]^. Aqueous deficient DED (ADDE) is associated with lacrimal gland dysfunction and loss of the aqueous layer of tears^[@CR2]^. Several causes for ADDE include, but are not limited to Sjögren's syndrome (... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Bakery products, bread, in particular, are widely consumed in Western societies and becoming more common for Asians with a modern and busy lifestyle. Bread can be consumed directly or used as a part of other food such as pizza and pudding. It is easy to prepare and hence, a popu... | {
"pile_set_name": "PubMed Central"
} |
The Staphylinidae or rove beetles represent one of the largest evolutionary radiations on earth with more than 56,000 species ([@B7], [@B17]) and are a dominant element of the insect fauna in many terrestrial ecosystems (examples discussed in [@B18]). Even though such an enormous diversity may seem unmanageable, we are... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Among critical care providers (physicians, nurse practitioners, physician assistants, and nurses), experience in dealing with patients and situations has been shown to improve patient outcomes \[[@pone.019... | {
"pile_set_name": "PubMed Central"
} |
The authors confirm that all data underlying the findings are fully available without restriction. All data are included within the manuscript.
Introduction {#s1}
============
Breast cancer is one of the most common malignancies in women worldwide and the second leading cause of cancer-related mortality in women. Acc... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
A common theme for the development of neurodegenerative diseases is the propensity of a number of proteins, such as α-synuclein, Huntingtin (HTT), and Tau, to misfold and form insoluble aggregates \[[@pone.0180892.ref001], [@pone.0180892.ref0... | {
"pile_set_name": "PubMed Central"
} |
Colorectal cancer is the second commonest cause of cancer death in Western Europe and North America. Many patients have evidence of locally advanced or metastatic disease at the time of initial presentation. Even in those undergoing apparently curative resection, only half survive for 5 years ([McArdle and Hole, 2002a]... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
The Plant Kingdom harbors an enormous reservoir of diverse chemicals. Accessing these molecules promises to reinvigorate drug discovery pipelines and provide novel routes to synthesize complex compounds that are beyond the reach of synthetic chemistry [@bib2]). Although breakth... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
The prevalence of chromosomal translocation carriers is about 1/500 in the general population. Although these translocations are usually balanced and associated to a normal phenotype, they can lead to recurrent abortions and malformations in the offspring through the fertilizati... | {
"pile_set_name": "PubMed Central"
} |
1. Definition of a plant-based diet {#s1}
===================================
A plant-based diet consists of all minimally processed fruits, vegetables, whole grains, legumes, nuts and seeds, herbs, and spices and excludes all animal products, including red meat, poultry, fish, eggs, and dairy products.
2. Overview {... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases, which are involved in molecular signaling related to cell growth and survival in many tumor types (Motoyama et al. [@CR15]). The human epidermal growth factor receptor 2, known as HER2 (sometimes as N... | {
"pile_set_name": "PubMed Central"
} |
The development of haploid spermatids into mature spermatozoa requires a lengthy duration and entails a series of complex physiological changes. During spermiogenesis, the spermatid-specific H2B variants are specifically synthesized and expressed in round spermatids to replace the canonical histones. H2B variants have ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Gliomas are the commonest primary brain tumour and they remain a leading cause of solid cancer-related deaths in the under 40s \[[@CR1]\]. Gliomas encompass a heterogeneous broad group of tumours with different cellular origins and variable biological behaviour. Classification of glio... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Dental caries is a chronic medical pathology of multifactorial origin that demineralizes the tissue of the tooth until the formation of a cavity if it is not treated in a timely manner ([@B1]-[@B3]).
The disease affects the general health and quality of life of people of all ages ([@B4]-[@B6... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-22-02131}
===============
With the progressive implementation of human whole-genome and microarray technologies, it is possible to simultaneously observe the expressions of numerous genes in different tissue samples. By analyzing gene expression data, genes with varying expressions in ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Protein expression is known to be regulated by the production and degradation of mRNAs and proteins, but details about their specific relationships are controversial [@bib1]. Although technological advances have enabled genome-wide and time-series surveys of mRNA and protein abu... | {
"pile_set_name": "PubMed Central"
} |
Case Presentation {#S1}
=================
A 60-year-old man with type II diabetes was referred to our department due to blisters and erosions over the whole body. He had been treated with linagliptin, a dipeptidyl peptidase-IV inhibitor (DPP4i), for 1 year. Two months before the referral, he had suffered a deep, 7-cm-... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
A contrast barium enema, or lower gastrointestinal series, is a solution of barium sulfate administered rectally as a diagnostic or therapeutic tool for colorectal diseases. Although the barium enema is a safe study for both benign and malignant conditions of the colon and the rectum, rare se... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#intro}
============
C-reactive protein (CRP), an acute-phase protein, is produced in hepatocytes. CRP is a phylogenetically highly conserved plasma protein that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a characteristic that has... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Atmospheric and oceanic processes are directly affected by increasing global temperatures and the Arctic has been the most severely impacted region to date [@pone.0027492-Screen1]. A long-term trend of deceasing minimum extent of summer sea ice was marked by a sharp decline and record l... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Lipids play diverse and important roles in nutrition and health and many lipids are absolutely essential for life. For instance, humans have dietary requirements for certain essential fatty acids (e.g., linoleic acid and α-linolenic acid), because they cannot be synthesized from simple precursors... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
==================
For the use of dansyl fluorescent analogs as insecticides and synergists, see: Himel *et al.* (1971[@bb3]). Dansyl probes have also been covalently incorporated into a variety of polymeric networks, see: Shea *et al.* (1989[@bb11]). Dansyl chromophoric compounds have been ... | {
"pile_set_name": "PubMed Central"
} |
Essay {#sec1}
=====
Cancer of esophagus is a serious health problem in sub-Saharan Africa and it is associated with high lethality \[[@cit0001]\]. Carcinogenesis of esophageal cancer (EC) is still largely unknown in sub-Saharan Africa. Several individual factors have been considered but the main cause is most likely m... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Atherosclerosis is a progressive and multifactorial disease conditioned by genetic and environmental factors and characterized by the accumulation of lipids in the intima and middle arterial layers. The clinical consequences of atherosclerosis constitute the underlying pathological process in... | {
"pile_set_name": "PubMed Central"
} |
Prostate cancer (PCa) is the most common male cancer \[[@CR1], [@CR2]\]. PCa initially depends on androgen receptor (AR) signaling for growth and survival. Androgen deprivation therapy causes a temporary reduction in PCa tumor burden, but the tumor eventually develops into castration-resistant prostate cancer (CRPC) wi... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Human helminthiases are of considerable public health importance in sub-Saharan Africa (SSA), Asia, and Latin America \[[@b1-kjp-53-5-561]-[@b7-kjp-53-5-561]\]. Helminths are a broad range of organisms that include intestinal parasitic worms. They are the most common infections worldwide when... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
The incidence of dialysis-dependent end stage renal failure is increasing. Preservation of adequate vascular access is of vital importance for patients undergoing chronic dialysis in end stage renal disease. Unfortunately, access-related morbidity adds significantly to total annual expenditur... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec001}
============
If an individual helps someone on the basis that they have helped others, indirect reciprocity can be said to be in action \[[@pone.0129442.ref001]\]. Indirect reciprocity is an important concept because it is integral to the notion that we may benefit from being seen to be cooperat... | {
"pile_set_name": "PubMed Central"
} |
GENOME ANNOUNCEMENT {#s0}
===================
*Tersicoccus phoenicis* DSM 30849^T^ is an aerobic Gram-positive bacterium belonging to the phylum *Actinobacteria*. It was first isolated from a National Aeronautics and Space Administration (NASA) spacecraft cleanroom which was thought to be biologically contaminant free... | {
"pile_set_name": "PubMed Central"
} |
CASE PRESENTATION
=================
A 3-month-old girl was diagnosed with primary congenital glaucoma (PCG) at birth. She was born via normal vaginal delivery and was the first child of healthy non-related parents. Ocular findings at birth are listed in [Table 1](#t1-JOVR-09-276){ref-type="table"}. She underwent trabe... | {
"pile_set_name": "PubMed Central"
} |
According to the United Nations High Commissioner for Refugees (UNHCR), the number of refugees worldwide has reached 25.4 million people, over half of whom are children (UNHCR, [2018](#CIT0048)). Refugee children face a wide range of stressful experiences, from exposure to war in their home countries through stressors ... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#SEC1}
============
In all living organisms, chromosome replication is highly regulated to ensure only one initiation event per chromosome per cell cycle ([@B1]). Bacteria have developed various strategies to prevent inappropriate re-initiation, principally by regulating the activity and/or the availabil... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
There is a large body of research demonstrating the existence of a significant association between severe socioeconomic deprivation (SED) and adverse childhood experiences (ACE) and the development of enhanced inflammatory status and/or hypothalamic--pituitary--adrenal (HPA) axis dysf... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Background
----------
According to the Centers for Disease Control and Prevention, motor vehicle crashes (MVC) are the leading cause of death in adolescents aged 12 to 19 years in the United States \[[@ref1]\]. MVC risk is disproportionately high among novice drivers, particularly those aged... | {
"pile_set_name": "PubMed Central"
} |
MIMIC-II is a public database and any interested researcher can gain direct access to MIMIC-II, without our help, upon completing human subjects training and signing a data use agreement (visit <http://physionet.org/mimic2> for instructions). The clinical part of MIMIC-II is a relational database and interested researc... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Universal health coverage (UHC) has become a rallying cry and pillar of the Sustainable Development Goals. Operationally, it can mean both focused reforms and sweeping health system changes. In its simplest formulation, UHC is understood as access to affordable, quality health services for al... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Liver enzymes such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have been used as markers of hepatic dysfunction and non-alcoholic fatty liver disease (NAFLD)^[@CR1]^. These enzymes have attracted attention as emerging risk fact... | {
"pile_set_name": "PubMed Central"
} |
All data were available from NCBI SRA ([www.ncbi.nlm.nih.gov/sra](http://www.ncbi.nlm.nih.gov/sra)) and NCBI Antibiograms ([www.ncbi.nlm.nih.gov/biosample/docs/antibiogram/](http://www.ncbi.nlm.nih.gov/biosample/docs/antibiogram/)). The accession numbers for the bacterial isolated used in this manuscript are available ... | {
"pile_set_name": "PubMed Central"
} |
I[NTRODUCTION]{.smallcaps} {#sec1-1}
==========================
The apnea surrounding the peri-intubation period can be dangerous leading to hypoxemia, which in turn can lead to cardiac arrhythmias, hemodynamic derangements, hypoxic brain injury, and even death. Preoxygenation is practiced commonly to increase the saf... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Understanding consciousness requires not only empirical studies of its neural correlates, but also a principled theoretical approach that can provide explanatory, inferential, and predictive power. For example, why is consciousness generated by the corticothalamic system -- or at least ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Neurofibromatosis type I (NF1) is a neurocutaneous disorder that involves autosomal dominant transmission. This disease is caused by a mutated NF1 gene on chromosome 17 and is characterized by inactive neurofibromin. The diagnostic criteria for NF1, with emphasis on the involvem... | {
"pile_set_name": "PubMed Central"
} |
Facts
=====
Emerging evidence suggests important roles for lipids and lipid metabolism in several non-apoptotic cell death pathways.Non-apoptotic cell death can be triggered by specific fatty acids.Specific lipids in the plasma membrane are essential for the execution of non-apoptotic cell death.Depletion of specific ... | {
"pile_set_name": "PubMed Central"
} |
The authors of the recent article by Cera *et al*. (published online 7^th^ June 2013) regret that the following information was omitted from the manuscript in error:
The authors gratefully acknowledge the funding for this project provided by the State of São Paulo Research Foundation (FAPESP 2008/52670-1) and the Nati... | {
"pile_set_name": "PubMed Central"
} |
Editorial Note on the Review Process
====================================
[F1000 Faculty Reviews](http://f1000research.com/browse/f1000-faculty-reviews) are commissioned from members of the prestigious [F1000 Faculty](http://f1000.com/prime/thefaculty) and are edited as a service to readers. In order to make these rev... | {
"pile_set_name": "PubMed Central"
} |
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