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Methicillin-resistant *Staphylococcus aureus* (MRSA) emerged in the 1960s and has since become a major cause of illness and death in the healthcare setting ([@R1]*,*[@R2]). Risk factors for infection with healthcare-associated MRSA (HA-MRSA) include hospitalization, residence in a long-term care facility, older age, in... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
Dental caries, a persistent infectious disease, affects billions of people with large individual differences in numbers of caries lesions and activity ([@bb0220]; [@bb0190]; [@bb0110]). At least half of school children and the vast majority of adults worldwide experience accord... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Single-cell RNA-sequencing (scRNAseq) analysis plays an important role in investigating tumour evolution, and is more powerful to characterize the intra-tumor cellular heterogeneity \[[@CR1], [@CR2]\]. Compared with traditional RNA sequencing (i.e. bulk RNAseq) which measures the specific... | {
"pile_set_name": "PubMed Central"
} |
Competing interest statement
============================
Conflict of interest: the authors declare no potential conflict of interest.
Introduction {#sec1-1}
============
As dramatic progress has been made in the therapeutic strategies for multiple myeloma (MM), in particular the development of proteasome inhibitors... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-20-01218}
===============
Mitochondrial transcription factor A (mtTFA, mtTF1, TFAM) is critical in regulating mitochondrial DNA (mtDNA) transcription, packaging and copy number \[[@B1-ijms-20-01218],[@B2-ijms-20-01218],[@B3-ijms-20-01218]\]. It was pointed out that suppressing the expressio... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS) with axonal injury, characterized by varying clinical course, pathology, and inflammatory patterns ([@B1]). It develops in susceptible hosts after interaction with environmental ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-biomedicines-08-00069}
===============
Replacement therapy using plasma-derived Factor IX (FIX) products is a life-saving treatment for patients with hemophilia B. Both recombinant and plasma-derived FIX show high efficacy in clinical trials \[[@B1-biomedicines-08-00069]\]. Production of FIX nor... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Silage is one of the most common feedstuff for ruminants in Europe. In 2015, the area of land harvested in Poland for this purpose exceeded 500.000 ha, and is still increasing each year (Central Statistical Office of Poland [@CR7]). Silage is mostly composed of maize, grass, clover, s... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Ulcerative colitis (UC) a chronic intestinal tract inflammatory disorder that is a type of inflammatory bowel disease (IBD) \[[@b1-medscimonit-26-e919530],[@b2-medscimonit-26-e919530]\]. UC usually causes bloody diarrhea, abdominal pain, and extraintestinal manifestations \[[@b3-medscimonit-26-e9... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-24-04165}
===============
Natural products play the central role in drug discovery \[[@B1-molecules-24-04165]\] due to their inherent biological activity and because have a wide span of structural diversity. Spirocyclic compounds have also occupied a special place in medicinal chemistr... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
There is a paucity of information concerning side-by-side comparison of real-time 3D echocardiography (RT3DE) and cardiac computed tomography (CCT) ventricular systolic performance assessment. We sought to compare those techniques with different temporal and spatial resolution, regarding left... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Capillaroscopy is a non-invasive diagnostic technique designed to evaluate small vessels of the microcirculation \[[@CIT0001]\]. Nailfold capillaries were first observed in the 17^th^ century with primitive magnifying equipment, and in the early 19^th^ century the first associations ... | {
"pile_set_name": "PubMed Central"
} |
In a unique collaboration between The Seventh Hospital of Hangzhou, the International Society for Traumatic Stress Studies (ISTSS), and the Zhejiang Behavior Medicine Association, the international conference "Posttraumatic stress: state-of-the-art research and clinical implications for China" was organized in Hangzhou... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Recent studies have demonstrated that several major nosocomial pathogens are shed by patients and contaminate environmental surfaces at concentrations sufficient for transmission \[[@CR1]--[@CR3]\]. Such pathogens can survive for extended periods despite cleaning with chlorine-releasing d... | {
"pile_set_name": "PubMed Central"
} |
Problem
=======
Quality and concise handover between clinicians is essential for patient safety \[[@R1]\]. At this time of increased risk during the patient\'s pathway the handover sheet is an important adjunct helping to reduce this risk \[[@R2]\]. The handover sheet within elective orthopaedic ward care takes on a v... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Carbon nanotubes (CNTs) have attracted particular interest because of their remarkable mechanical and electrical properties \[[@B1]\]. The combination of these properties with very low densities suggests that CNTs are ideal candidates for high-performance polymer composites \[[@B2]\]. In orde... | {
"pile_set_name": "PubMed Central"
} |
Sir,
Leiomyoma is the most common tumor of uterus and female pelvis. Leiomyosarcoma almost always arise de novo and almost it doesn't results from sarcomatous transformation of a leiomyoma. One of the most controversial concepts on the subject of uterine smooth muscle tumors is smooth muscle tumor of uncertain maligna... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Ultrasonic nebulizers or atomizers are very important due to their many applications such as drug delivery, mass spectrometry, humidity control, spray pyrolysis, coating, etc. In almost all cases, the distribution of droplet sizes is an important parameter. For example, in many drug d... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Alpha (α)-asarone \[1,2,4-trimethoxy-5-\[(E)-pro-1-enyl\] benzene; Pubchem CID: 636822; **Figure [1](#F1){ref-type="fig"}**), is one of the main pharmacologically active compounds present in *Acorus calamus* Linn (Acoraceae), *Acorus tatarinowii* Schott (Acoraceae), and *Acorus gramineus* Sol... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
Dopamine (DA) is a biogenic amine neurotransmitter found in both vertebrates and invertebrates that affects a wide variety of physiological and behavioral functions, including reproduction\[[@pone.0193999.ref001],[@pone.0193999.ref002]\], hor... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Antibodies are the primary tools of the immune system, which participate in the protection of the organism against pathogenic microorganisms. The significance of antibodies is growing as researchers become aware of their potential not only as tools to be used in diagnostics, but in therapy as... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Starting with winter semester 2003/2004, the University of Cologne introduced the new degree course at the medical faculty called 4C (Competence-based Curriculum Concept Cologne) \[[@R1]\], \[[@R2]\], \[[@R3]\]. Apart from fulfilling the goals of the Medical Licensure Act (Approbationsordnung... | {
"pile_set_name": "PubMed Central"
} |
**Core tip:** This article reviews the current role of diffusion weighted imaging for various oncological and non-oncological applications in the liver.
INTRODUCTION
============
Diffusion-weighted imaging (DWI) is a functional imaging technique, allowing qualitative and quantitative assessment of the diffusion prope... | {
"pile_set_name": "PubMed Central"
} |
I. INTRODUCTION & BACKGROUND {#acm20054-sec-0001}
============================
Magnetic resonance imaging (MRI) is increasingly used in radiation oncology departments for radiation treatment planning because of the excellent contrast for soft tissues and tumors.^(^ [^1^](#acm20054-bib-0001){ref-type="ref"} ^--^ [^3^](... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The epidemiological effects of public disease-risk mitigation measures such as quarantines, school closures, vaccinations, trade interdictions, or travel restrictions have attracted considerable attention (see (Chowell et al. [@CR14]; Ferguson et al. [@CR21]; Chowell et al. [@CR15]; S... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .447}
{#sp2 .448}
{#sp3 .449}
{#sp4 .450}
{#sp5 .451}
{#sp6 .452}
{#sp7 .453}
![](brforeignmcrev72771-01... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The morphogenesis and functional development of the mammalian central nervous system is regulated by the interaction of genes expressed at specific times and locations during development. The roles of these genes can be better understood by studying their spatial and temporal expression patte... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
The *pugilist* (*pug*) gene of *Drosophila melanogaster* encodes an enzyme with three activities in tetrahydrofolate metabolism. Null mutations of *pug* cause a subtle, transitory and recessive reduction in pteridine pigmentation in the eyes ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
*Diuraphis noxia* (Kurdjumov, Hemiptera: Aphididae---or Russian wheat aphid, RWA) biotypes are morphologically similar, yet display vast differences in their capacity to damage wheat cultivars upon feeding (i.e., their virulence) (Botha, [@B11]). In South Africa, the virulence of the fo... | {
"pile_set_name": "PubMed Central"
} |
The sequence data for L. infantum 263 AMB1000.1 is available at the EMBL European Nucleotide Archive (<http://www.ebi.ac.uk/ena>) under study accession ERP001815.
Introduction {#sec001}
============
Protozoan parasites belonging to the *Leishmania* genus cause several vector-borne diseases collectively referred as le... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .466}
| {
"pile_set_name": "PubMed Central"
} |
Transplant patients may have preexisting diabetes mellitus or develop transient postoperative hyperglycemia or permanent new-onset diabetes after transplantation (NODAT). NODAT increases mortality rate due to allograft rejection and also leads to increased cardiovascular disease.\[[@ref1]\] NODAT excludes transient pos... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Importance of C-allocation in biotechnology and ecology
Recently, microalgae have attracted increased attention in the field of biomass production and biosynthesis of feed stock components or high valuable products like polyunsaturated fatty acids, antioxidants, pigments like carotenoi... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Head and neck cancer (HNC) is the sixth most common cancer worldwide \[[@CR1]\]. Currently, there are more than 62,000 people living with head and neck cancer in the UK \[[@CR2]\]. In Scotland, where incidence rates are significantly higher than the rest of the UK, a 37 % rise is predicte... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The World Health Organization (WHO) announced on Wednesday, March 11, 2020, the new coronavirus "COVID-19" disease as "a global epidemic" (WHO [@CR37]). In response to that, governments around the world have been taking a range of actions and measures, including the closing of schools... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Breast cancer (BRCA) is among the most common cancers diagnosed in women in Europe where it also is the third cause of cancer death after lung and colorectal cancer \[[@CR1]\]. Approximately 75% of breast tumours is characterized by the expression of estrogen receptor alpha (ERα), encoded... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The rising utilization and success of *in vitro* fertilization (IVF) can be attributed to the optimization of several clinical and laboratory protocols \[[@B1]\]. One such example is the optimization of controlled ovarian stimulation (COS) by incorporating gonadotropin-releasing hormone antag... | {
"pile_set_name": "PubMed Central"
} |
I am writing regarding the systematic review about clinical validity, understandability, and actionability of online cardiovascular disease (CVD) risk calculators recently published by Dr Bonner and colleagues \[[@ref1]\].
Although Dr Bonner and colleagues used a comprehensive two-step research strategy to identify We... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The incidence and mortality rates of colorectal cancer (CRC) vary around the world ([@b1-or-43-04-1187],[@b2-or-43-04-1187]). Early stage CRC commonly shows limited clinical signs, and patients are often diagnosed at the metastatic stage, rendering therapy difficult ([@b3-or-43-04-1187]). The... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The *Salmonella*e are major human pathogens and represent a significant global public health issue causing morbidity and mortality resulting in a high social and economic burden worldwide ([@ref-19]). The genus consists of two species; *Salmonella enterica* and *S. bongori*. There are six sub... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Metalloporphyrin π-cation radicals are of immense interest due to their occurrence as intermediates in the catalytic cycle of many heme containing enzymes, *e.g.*, peroxidases,[@cit1] catalases,[@cit2] cytochrome P450 [@cit1a],[@cit3] *etc.*, and their photosynthetic reaction center.[@cit4] I... | {
"pile_set_name": "PubMed Central"
} |
J. Liu, D. Reta, J. A. Cleghorn, Y. X. Yeoh, F. Ortu, C. A. P. Goodwin, N. F. Chilton, D. P. Mills, *Chem. Eur. J.* **2019**, *25*, 7749.
Introduction {#chem201901167-sec-0001}
============
Since the discovery of ferrocene \[Fe(Cp)~2~\] (Cp=cyclopentadienyl, C~5~H~5~) in the middle of the 20th century,[1](#chem201901... | {
"pile_set_name": "PubMed Central"
} |
{
"pile_set_name": "PubMed Central"
} | |
Introduction {#s1}
============
Friedreich\'s ataxia (FRDA) is an autosomal recessive progressive hereditary neurodegenerative disorder caused by a GAA repeat expansion in the first intron of the *FXN* gene on chromosome 9 ([@B1]). The prevalence in the Caucasian populations is 2--5:100.000 ([@B2]). FRDA is characteri... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
In human and nonhuman primates, the face plays an important role in social communication ([@R10]; [@R49]; [@R64]). In some species, such as macaques (*Macaca mulatta*, *M. fuscata*), and mandrills (*Mandrillus sphinx*), facial morphology may signal fertility ([@R21]; [@R53]; [@R56]). Th... | {
"pile_set_name": "PubMed Central"
} |
Dear Editor-in-Chief
====================
Most of anti-cancer drugs have mutagenic, clastogenic, and carcinogenic properties. Studies on oncology nurses and personnel handling cytostatic drugs showed that the frequencies of chromosomal aberrations, sister chromatid exchanges, and micronuclei were significantly increas... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
*Acanthaspis cincticrus* (Stål) (Hemiptera: Reduviidae) is a predatory assassin bug, which feeds on ants and can be found in the vicinity of ant nests, waiting for the preys^[@CR1]^. This species is native to Oriental Region with one generation per year. Nymphs of this species have fi... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
ERK mitogen-activated protein (MAP) kinases are commonly activated by 7TMRs, which leads to a wide array of cellular processes including cell proliferation and cell differentiation. In the last decade, a tremendous amount of works have been dedicated to elucidate the cell signaling mechanisms whe... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
The bacteria *Streptococcus pneumoniae* (pneumococcus) and *Haemophilus influenzae* type b (Hib) are leading causes of childhood pneumonia and meningitis and are major contributors to worldwide mortality in children younger than 5 years of age. In 2011, an estimated 411,000 deaths occurre... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Our group has previously demonstrated that antibodies to a 140 kDa protein detected by protein immunoprecipitation (known as anti-p140 or P140) in JDM were strongly associated with the development of calcinosis, a major cause of morbidity \[[@keu259-B1]\]. The presence of autoantibodies to a ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Secondary amyloidosis can complicate chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA) and ankylosing spondylitis. However, the clinical findings of primary amyloidosis may mimic those of primary rheumatologic disorders. We present the case of a 53-year-... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec005}
============
Preparedness is a state of readiness to respond to crises \[[@pone.0156536.ref001]\], with one aim being to reduce negative outcomes. When preventive work is effective, it is invisible. Preparedness for disaster often includes a written emerg... | {
"pile_set_name": "PubMed Central"
} |
Findings {#Sec1}
========
Infections are uncommon causes of scleral inflammation \[[@CR1]\]. Diagnosis is often difficult and gets delayed as the clinical picture appears similar to the more common cause: the immune-mediated disease. Fungal infections of the sclera have been reported following surgeries for retinal de... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction {#s0001}
================
Carbonic anhydrases (CAs, EC 4.2.1.1) are important metalloenzymes involved in the hydration of carbon dioxide, a quite simple reaction whose balance is important in many cellular and physiological processes, spanning from pH homoeostasis and respiration to biosynthetic pathw... | {
"pile_set_name": "PubMed Central"
} |
Study rationale {#sec1}
===============
Infectious diseases, nutritional deficiencies and maternal and neonatal conditions are the dominant contributors to the overall burden of disease worldwide \[[@ref1]\]. However, the burden of non-communicable diseases (NCDs) such as diabetes, cardiovascular disease and cancer, h... | {
"pile_set_name": "PubMed Central"
} |
Dear Editor:
Hailey-Hailey disease (HHD), also known as benign familial pemphigus, is a chronic recurrent bullous and vesicular dermatitis, presented histologically withsuprabasilar acantholysis[@B1]. Flexural sites, especially lateral side of neck, groin and axillae are affected. Patients are suffered by chronic eros... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-polymers-11-01937}
===============
The use of naturally renewable biopolymers (e.g., starch, cellulose, chitosan/chitin, caseinate, and pectins) as edible and biodegradable films and coatings constitute an actual and sustainable choice to prevent the post-harvest losses of very perishable fruits... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The omohyoid muscle typically has an inferior belly originating from the superior border of the scapula, near the suprascapular notch, and occasionally, from the superior transverse scapular ligament \[[@B1]\]. This muscle then passes deep to the sternocleidomastoid where its superior belly p... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Acrodysostosis (ACRDYS) is a rare skeletal dysplasia with skeletal abnormalities and multi-hormonal resistance similar to PHP1A, but caused by mutations downstream of the genes involved in PHP1A. Whereas PHP1A results from mutations of the gene encoding the Gα-stimulatory subunit (*GNAS*)... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
In the gastrointestinal tract, interstitial cells of Cajal (ICC) function as pacemakers, neurotransmitter transducers, and mechanosensors that respond to physical and chemical signals, and thereby modulate smooth muscle contractility [@pone.0048897-Won1], [@pone.0048897-Choi1], [@pone.0... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
A carpometacarpal joint (CMCJ) of the thumb is important for the function of the thumb and in the performance regarding strong pinch and grasp. The dislocation of the CMCJ in the thumb accounts for less than 1% of all hand injuries.[@B1] Mechanical instability for the CMCJ of the thumb is an important factor, which may... | {
"pile_set_name": "PubMed Central"
} |
Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder in which cortisol and adrenal androgen secretions are deficient due to adrenal unresponsiveness to ACTH stimulation. The most significant phenotypic features are severe neonatal hypoglycemia, frequent childhood infection, and excessive gene... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Previous studies suggested that surgery using polypropylene mesh could offer a better anatomical cure of pelvic organ prolapse (POP) \[[@CR1]\]. A large UK-based surgical randomised controlled trial (RCT) (PROSPECT, PROlapse Surgery: Pragmatic Evaluation and randomised Controlled Tria... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Adipose tissue-derived mesenchymal stem cells (ASCs) with autologous fat improve the regenerative ability and retention of fat grafts and are increasingly being used for breast reconstruction of breast cancer patients following mastectomy \[[@B1]\]. However, increasing evidence ... | {
"pile_set_name": "PubMed Central"
} |
Data are owned by each centre that contributed to the ARPEC project. The ARPEC steering committee was in charge of approval of proposed analyses for abstracts and publications, delegating this to work package leads, if appropriate. The work package lead for ARPEC point prevalence surveys was Prof. Herman Goossens who t... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Conjunctivitis is a collective term for a diverse group of diseases that are characterized by inflammation of the conjunctiva.[@CIT0001] The most common cause of infectious conjunctivitis is viral infection (\~80% of cases), followed by bacterial.[@CIT0001],[@CIT0002] The noninfectio... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Nowadays, the internet is an essential part of everyday life, as it enables the fluidity necessary for the circulation of information and global communication.[@B1] ^,^ [@B2] Although there are benefits to this, a new pathology called internet addiction has occurred.[@B1] ^,^ [@B3] ^,^ [@B4] ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-14-00012}
===============
Worldwide, *Legionella* is an opportunistic pathogen of public health concern \[[@B1-ijerph-14-00012],[@B2-ijerph-14-00012]\]. It is the causative agent of Legionellosis which includes Legionnaires' disease, an atypical pneumonia, and Pontiac fever, an acute febr... | {
"pile_set_name": "PubMed Central"
} |
Correction to: Protein Cell 10.1007/s13238-019-00668-8 {#Sec1}
======================================================
In the original publication the bands in Fig. 1J and Fig. 2B were not visible. The correct versions of Fig. [1](#Fig1){ref-type="fig"}J and Fig. [2](#Fig2){ref-type="fig"}B are provided in this correct... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Atypical antipsychotics (AAPs) are an effective treatment for many types of mental illnesses. According to treatment guidelines, antipsychotics are recommended for schizophrenia treatment \[[@CR1]--[@CR3]\], for the treatment of bipolar disorders \[[@CR4], [@CR5]\], and in some cases, as ... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
According to the global burden of disease study, COPD will be the fifth leading cause of disability and the third leading cause of death in the world in the first half of the twenty-first century. For developing countries, COPD is expected to be the fourth leading cause of disabilit... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Although the US has achieved substantial gains in improving the health of women and children, and infant mortality has reached record low levels, the US presently ranks 27th among established market economies in infant mortality \[[@CR1]\]. Four recurring causes account for more than ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Over the past few decades, studies have found that regulated intramembrane proteolysis (RIP) plays an important role in various kinds of cellular processes, including cell signaling, gene transcription and apoptosis [@pone.0037452-Brown1], [@pone.0037452-Wolfe1]. Regulated intramembrane... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
In recent decades, breast cancer cases have increased worldwide [@pone.0053902-Pedraza1] and today are the main cause of cancer mortality and morbidity in women [@pone.0053902-Hortobagyi1]. Breast cancer is caused by environmental and genetic factors [@pone.0053902-Song1]. Two main gene... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The three-year mandate of the European Union Committee of Experts on Rare Diseases \[[@B1]\] drew to a close in July 2013 with an impressive record. These results were achieved thanks to the unique nature of the forum it provided for the discussion of key topics for the rare disease community... | {
"pile_set_name": "PubMed Central"
} |
Specifications tableSubject area*Ecology, Conservation Biology*More specific subject area*Urban ecology*Type of data*Tables, graphs*How data was acquired*Floristic inventories and vegetation relevés*Data format*Raw and aggregated*Experimental factors*A stratified sampling design with two types of gardens, and two cross... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
The dexamethasone implant (OZURDEX; Allergan Inc., Irvine, CA, USA) is a biodegradable, sustained-release device injected transconjunctivally into the vitreous cavity, containing 0.35 or 0.7 mg of dexamethasone. The implant has been approved by the Food and Drug Administration for u... | {
"pile_set_name": "PubMed Central"
} |
Human movement, cognition, and learning are inextricably bound. Starting in early life, children act upon and understand the environment using mainly sensorimotor actions ([@B160]). Broad changes in perception, cognition, and behaviour appear with the development of a child's sensorimotor repertoire ([@B131]). Differen... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Physical exercises are prescribed in some institutions for patients that wear braces for adolescent idiopathic scoliosis \[[@B1]-[@B3]\], but there is no scientific evidence for this practice \[[@B4],[@B5]\].
The possible useful effects of an exercise regimen for a patient with adolescent idiopa... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Human parvovirus B19 is considered an important trigger of aplastic crisis in patients with chronic congenital hemolytic disorders.
Case report
===========
We describe the case of a young adult known with hereditary microspherocytosis who presented with fever, marked agitation and confusion and... | {
"pile_set_name": "PubMed Central"
} |
Abbreviations used in this paper: α1-AT, α1-antitrypsin; COPII, coat protein II; ERGIC, ER Golgi intermediate compartment; MCFD2, multiple coagulation factor deficiency protein 2; MEF, mouse embryonic fibroblast; PCA, protein fragment complementation assay.
Introduction
============
The lumen of the ER provides a uni... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
*Orostachys japonicus* (*O. japonicus*) is traditionally used as an inflammatory agent, antifebrile, homeostatic agent, and antidote and anticancer agent \[[@B1]\]. The methanol extract of*Orostachys japonicus*is thought to contain several different classes of phytochemicals, in... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-2331216515569792}
============
Cochlear implants (CIs) are neural prostheses for individuals who have severe or profound hearing loss. These devices consist of an array of electrodes that are inserted into the inner ear to stimulate the auditory nerve. The auditory nerve has a tonotopic organizatio... | {
"pile_set_name": "PubMed Central"
} |
Sevoflurane is a volatile anesthetic with a low blood--gas partition coefficient and produces a rapid induction and recovery of anesthesia \[[@r16]\]. During last decade, clinical use of sevoflurane has been spreading in veterinary practice. Sevoflurane is minimally metabolized and easily cleared in animals, however, i... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Clear cell sarcoma of soft tissue (CCSST) is a malignant mesenchymal tumor that mostly affects young adults and tends to affect the lower extremities, close to the tendon and aponeuroses \[[@CR1]\]. Histologically, CCSSTs have epithelioid tumor nests accompanied by some spindling areas, a... | {
"pile_set_name": "PubMed Central"
} |
{
"pile_set_name": "PubMed Central"
} | |
T. W. Ford, P. A. Kirkwood. Sympathetic discharges in intercostal and abdominal nerves. Physiol Rep, 6 (11), 2018, e13740, <https://doi.org/10.14814/phy2.13740>
**Funding Information**
This experimental work was supported by the Jeanne Anderson Fund (Institute of Neurology), the Wellcome Trust (038027/Z/93/Z/1.5), th... | {
"pile_set_name": "PubMed Central"
} |
A hallmark of tumor cells is their ability to grow anchorage independent. Proliferation and survival of tumor cells, determining progression of solid tumors, are independent of signals elicited by interactions with the surrounding extracellular matrix (ECM^1^; [@B17]). In contrast, normal diploid cells require anchorag... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#section1-1176934319838818}
============
Lily is a perennial bulbous flower in the monocotyledon subclass, *Liliaceae* family and *Lilium* genus, with an extremely high ornamental value. China is a large producer of lily cut flowers. As the planting of lily continues and the planting area of lily expands... | {
"pile_set_name": "PubMed Central"
} |
**A Primer of Ecology with R**
M. Henry H. Stevens
New York:Springer, 2009. 388 pp. ISBN: 978-0-387-89881-0, \$64.95
**Acute Exposure Guideline Levels for Selected Airborne Chemicals: Vol. 8**
Committee on Acute Exposure Guideline Levels; Committee on Toxicology; National Research Council
Washington, DC:National A... | {
"pile_set_name": "PubMed Central"
} |
All protein array data files are available from the Array Express database (accession number E-MTAB-7622).
Introduction {#sec001}
============
The absence of Reelin--a glycoprotein crucial for physiological retinogenesis--has been recently associated with changes in both Nerve Growth Factor (NGF) protein and mRNA in ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
The number of total hip arthroplasties (THA) carried out in Germany has increased in recent years up to 160,000 annually \[[@CR1]\]. The main reasons for this are the aging of the population and technical improvements in orthopedic surgery. The current rate of prosthetic joint infection (... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Treatment of horses for infection of a limb with *Pythium insidiosum* is challenging, and its effectiveness appears to depend on such factors as size and site of the lesion, duration of infection, immunocompetence, and the type of treatment. Systemically administered antifungal drugs, suc... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Physical inactivity has been recognized as a major modifiable risk factor for non-communicable diseases (NCDs) since the 1950s \[[@CR1]\]. Recent reports have equated the impact of physical activity (PA) to that of smoking with respect to the worldwide burden of NCDs \[[@CR2]\]. Physi... | {
"pile_set_name": "PubMed Central"
} |
Learning pointsAs the number of transcatheter aortic valve implantation (TAVI) has increased in the last decade, a unique set of post-intervention events and complications have been identified.This is the first clinical case report to describe the occurrence of acute necrotizing oesophagitis (ANE) as a possible complic... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Infections owing to soil-transmitted helminths and foodborne trematodes are serious public health problems in Laos.[@CIT0001]--[@CIT0003] Previous studies have reported a high prevalence of intestinal parasitic infections among school-aged children and young people in Laos. For examp... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Adverse food reactions (AFRs) are defined as abnormal responses to an ingested food or food additive \[[@CR1], [@CR2]\]. When an AFR is suspected, its diagnosis should always be based on a complete and accurate dietary history, clinical signs and, in particular, on the results of a dietar... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In recent years, inequalities with power-exponential functions have been intensively studied \[[@CR1]--[@CR7]\]. They have many important applications. For example, they can be found in mathematical analysis and in other theories like mathematical physics, mathematical biology, ordina... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Natural Killer (NK) cell neoplasms are a rare and heterogeneous group of disorders characterized by excessive proliferation of cytotoxic CD3^−^ CD16/56^+^ NK cells. This group comprises two subtypes: aggressive NK leukemia (ANKL) and chronic lymphoproliferative disorder (CLPD) \[[@R1], ... | {
"pile_set_name": "PubMed Central"
} |
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