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Overview
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High-throughput studies revealed that the transcriptome does not always predict the proteome ([@B59]; [@B85]; [@B95]), highlighting the need for a better understanding of post-transcriptional regulation in order to explain this discrepancy. Post-transcriptional regulation is comprised of a complex an... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
The incidence of diaphragmatic hernia is 1:2000--1:4000 live births. Its presentation is rare in the adults. The presentation in infancy is due to signs and symptoms of respiratory distress. However, in adults, the presentation is mostly asymptomatic or might present with respirator... | {
"pile_set_name": "PubMed Central"
} |
SummaryMore than half of patients who are treated for multiple brain metastases with whole brain radiation therapy (WBRT) will develop intracranial progression. This multi-institutional pooled analysis included 205 patients from 9 centers who received 2 courses of whole brain radiation therapy, both for multiple metast... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Paraneoplastic neurologic syndromes (PNSs) can be the first symptom of a covert malignancy. Early treatment of PNS may improve the morbidity and mortality rates of cancer patients. Advances in antibody-detection techniques have enabled definitive diagnoses in patients with paraneoplasti... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
Briefings in Bioinformatics (2016) doi: 10.1093/bib/bbw145
In the article above, the following errors have been addressed: • In Table 1, the SHS formula was incorrectly given as ${SHS} = U_{R}\text{diag}\left( {\xi_{1} + \delta,\cdots,\xi_{n} + \delta} \right)U_{R}^{T}$. This has been corrected to ${SHS} = U_{R}\text{... | {
"pile_set_name": "PubMed Central"
} |
The COVID-19 viral pandemic is bearing down on the United States. Thousands have died in China and in Italy, and every country in the world is or will be affected. At home every sniffle or cough elicits a brief pang of fear. To fight the deadly virus, we are turning to methods that proved partly effective in the flu ep... | {
"pile_set_name": "PubMed Central"
} |
As we approach the second anniversary of the launch of *PLoS Pathogens*, it is evident that the journal has rapidly established itself as an important publication in the field of pathogen--host interactions (Image 1). We attribute this success to the commitment and motivation of our talented editorial board, to a recep... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Conversion of common murine models to an immune-compromised state has become highly desirable for translational research. The creation of immune-compromised mouse strains allows for the preclinical efficac... | {
"pile_set_name": "PubMed Central"
} |
More than 13 000 new cases of rectal cancer are diagnosed every year in the UK ([Office for National Statistics, 2003](#bib38){ref-type="other"}; [Northern Ireland Cancer Registry, 2007](#bib36){ref-type="other"}; [Welsh Cancer Intelligence and Surveillance Unit, 2007](#bib49){ref-type="other"}). At least 10% of these ... | {
"pile_set_name": "PubMed Central"
} |
Files are available from the Open Science Framework platform (<https://osf.io/c3ztu/>).
Introduction {#sec001}
============
To execute a hand reaching movement, the central nervous system needs to localize the target with respect to the hand. Its position can be derived from inputs provided by one or multiple sensory... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Despite the effectiveness of antiretroviral therapy (ART) to suppress viral loads and decrease HIV-related mortality, HIV remains a global epidemic. The World Health Organization (WHO) estimates that of the 36.7 million people currently living with HIV worldwide, only 48% are being trea... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The International Study of Asthma and Allergies in Childhood (ISAAC), created in 1990 to maximize the value of epidemiological studies of asthma and allergic diseases, established a standardized method that facilitated international collaboration, from the establishment of a protocol used wor... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-17-03529}
===============
Sleep paralysis (SP) is a common condition that affects approximately 7.6% of the general population during their lifetime \[[@B1-ijerph-17-03529]\]. The episodes happen either during sleep onset or offset and entail gross motor paralysis coupled with full consci... | {
"pile_set_name": "PubMed Central"
} |
GENOME ANNOUNCEMENT {#h0.0}
===================
Bacterial neonatal meningitis, one of the most devastating infections in the early period of human life, accounts for high mortality and morbidity among infants ([@B1]). *Escherichia coli* is the second most common pathogen associated with neonatal meningitis, and it acc... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction
============
Hepatocellular carcinoma (HCC) accounts for up to 90% of all malignant primary liver cancer worldwide and represents a major health threat.[@b1-ijn-13-1621] Currently, apart from surgery, patients with liver cancer are mainly treated by chemotherapy.[@b2-ijn-13-1621] However, chemotherapy is ... | {
"pile_set_name": "PubMed Central"
} |
Xie L, Peng Y, Huang K, Wu Y, Wang S. Predictive value of iron parameters in neurocritically ill patients. Brain Behav. 2018;8:e01163 10.1002/brb3.1163
1. INTRODUCTION {#brb31163-sec-0005}
===============
Iron has many different roles in the body, acting in carrying oxygen, delivering electron, and catalyzing many bi... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Vesicoureteral reflux (VUR) is an important disorder in children because of high association with urinary tract infection (UTI) and permanent renal damage (scar)^\[[@CIT0001]\]^. Reflux--associated nephropathy is one of the most important causes of end stage renal disease and kidney ... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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INTRODUCTION {#sec1-1}
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According to international registry of heart--lung transplant, the annual cardiac transplant rate worldwide varies between 5000 and 10,000 and this number is expected to increase.\[[@ref1]\] These patients may require anaesthesia for elective or emergency surgery in hospitals where ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The neural mechanisms that regulate and coordinate breathing and respiratory-related behaviors such as coughing are not well understood. This lack of knowledge hampers elucidation of pathophysiological deficits in airway protection and impedes development of new therapeutic approaches for dys... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-vaccines-07-00065}
===============
Pertussis is a globally endemic and highly infectious disease that can cause respiratory, nutritional and neurological complications, and death \[[@B1-vaccines-07-00065]\]. Infants and young children have the highest risk of pertussis sequelae and death during ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Regenerative myogenesis has emerged as arguably one of the most powerful paradigms to investigate a variety of processes involving stem cells and tissuegenesis. Adult skeletal muscle satellite (stem) cells emerge from a proliferative population of myogenic cells that reversibly exit t... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Perinatal mortality in the Netherlands
--------------------------------------
Perinatal mortality and morbidity in the Netherlands is relatively high compared to other countries in Europe, shown by Peristat I (data of 1999) \[[@B1]\] and Peristat II (data of 2004) \[[@B2]-[@B4]\]. Initiated by t... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction
============
Chemical molecules, especially volatile ones, are the vessel of crucial information that may determine an animal's eventual survival and reproductive success. Perhaps for this reason, the sense of chemoreception is ubiquitously represented in the animal kingdom (Ache and Young, [@B2]). The ro... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Inflammatory disorders can affect virtually any organ and are a frequent cause of morbidity. Recently, immunotherapies emerged as highly efficient treatments in specific inflammatory diseases. Since their prescription is rapidly increasing, their cost represents a growing burden for h... | {
"pile_set_name": "PubMed Central"
} |
Melioidosis causes severe sepsis and death in the Top End of Northern Australia during the monsoonal wet season.[@bib1] The wet season (melioidosis season) is defined to capture the seasonal presentation in the tropical wet season (November to April),[@bib2] with average monthly rainfalls of 100 to 500 mm in the 6 mont... | {
"pile_set_name": "PubMed Central"
} |
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Introduction
============
To obtain system-level descriptions of biological and cellular events, transcriptome profiling, including recent RNA-sequencing approaches,^[@bib1]^ has generated large, unmanageable high-throughput data sets.^[@bib2]^ To make sense of these gene expression data sets, researchers have develop... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Psoriatic arthritis (PsA) is a multifactorial chronic inflammatory joint disease associated with psoriasis, usually with no detectable rheumatoid factor (RF), and belongs to the seronegative subgroup of spondyloarthritis \[[@B1]\]. Clinically, patients with PsA present with diff... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Tuberculosis (TB) is one of the ancient and deadliest disease of mankind, still posing a major health, social and economic burden at a global level and primarily in low and middle income countries.[@b1-mjhid-5-1-e2013070] The lack of an effective vaccine, the long and expensive drug regimens,... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Low-molecular-weight gelators have started to evoke considerable interest in recent years on account of their application in cosmetics,^[@ref1]^ food industry,^[@ref1]^ controlling/triggering drug release,^[@ref2],[@ref3]^ tissue engineering,^[@ref3],[@ref4]^ sensors,^[@ref5]^ templat... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Human cytomegalovirus (HCMV) is predominantly an opportunistic pathogen, causing clinically significant disease in people who have inadequate immune responses, including neonates, transplant recipients, and people with uncontrolled HIV infections \[[@B1-viruses-06-00476]\]. Viral replic... | {
"pile_set_name": "PubMed Central"
} |
**W**ilhelm Hasselbach (1921--2015) was born in Falkenstein, a small village north of Frankfurt/Main, Germany. For most of his life he worked and lived in Heidelberg, where he was a director at the Max Planck Institute for Medical Research. He is probably best known for the discovery of the *calcium pump* of the sarcop... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Down syndrome (DS) is a complex disorder caused by trisomy of the entire or a critical portion of chromosome 21 (HSA21); it represents the most frequent genetic cause of mental retardation, with a frequency of about 1/1000 new-borns, and is associated with a huge number of congenital heart defect... | {
"pile_set_name": "PubMed Central"
} |
The electronic version of this article is the complete one and can be found at: <http://f1000.com/prime/reports/b/5/27>
Introduction {#s01}
============
Heart failure is a leading cause of death in the United States and is mentioned in one out of nine death certificates \[[@bib-001]\]. Survival after diagnosis has im... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-14-00773}
===============
Humans evolved into their current form over 6--7 million years, beginning with our ancestors' evolution from a subset of primates \[[@B1-ijerph-14-00773]\]. This period represents 99.99% of the span of human evolution, during which time we lived in a natural envi... | {
"pile_set_name": "PubMed Central"
} |
A significant fraction of the organic carbon produced in the surface sunlit ocean through photosynthesis is exported into the deep ocean as sinking particles ([@r1], [@r2]), supporting a globally relevant carbon flux fueling the generally starved bathypelagic microbial communities ([@r3], [@r4]). Although the carbon re... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Comprehensive care for people diagnosed with psychosis includes access to adjunctive evidence based psychosocial interventions \[[@CR1], [@CR2]\]. Cognitive remediation therapies for psychosis are recommended in the recently updated Australian and New Zealand College of Psychiatrists clin... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-marinedrugs-17-00119}
===============
Most naturally occurring fatty acids have an unbranched chain consisting of an even number of carbon atoms ranging from 4 to 28. Depending on the nature of the hydrocarbonated chain, the fatty acids can be saturated, monounsaturated, or polyunsaturated \[[@B... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Pest activities are one of the major problems associated with farming. The animal rearing and creation, as well the management of farming lands, disrupts the ecological stability that regulates potential pest species \[[@CR1]\]. Insects and other arthropods are particularly problematic pe... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s0001}
============
For advanced chronic kidney disease patients who will be initiated on HD therapy soon, the type of vascular HD access remains a big challenge. Guidelines from different countries strongly recommend native arteriovenous fistula (AVF) as the best method for dialysis amongst patients wh... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Aphids (Insecta: Hemiptera), a group of economically important insect pests that consume plant phloem sap, cause substantial losses of crop yield by direct feeding on host plants and by vectoring plant viruses (Dixon, [@B22]). More than 450 species within Aphididae attack agricultural a... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Dengue is a mosquito-borne viral infection caused by one of the four dengue virus serotypes (DENV-1 to 4), belonging to genus *Flavivirus*, family *Flaviviridae.* The viruses replicate alternately on the mosquito vector, mainly (*Ae. aegypti*) and human host and are responsible for infections thr... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction {#sec1}
==================
Precipitation or aggregation of proteins is often problematic when handling protein solution for research and commercial use. Developing methods to inhibit undesired aggregation of proteins is one of the critical issues in the biopharmaceutical field (Shire *et al.*, 2004[... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Across all healthcare settings, clinicians perceive particular patients as \'difficult\' \[[@B1]\]. High users of medical services, these patients are generally unsatisfied with the care they receive \[[@B2]-[@B6]\] and may evoke strong negative emotions in clinicians \[[@B1],[@B7]\]. Although cl... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Prostate cancer is the sixth most frequent cancer in the world (in the number of new cases), the third most common cancer in men, and the most frequent cancer in men in Europe, North America, and some parts of Africa \[[@CIT0001]\]. The most general sites of prostate cancer distant m... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction {#Sec1}
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An elastance--resistance model is an effective tool to quantify the systolic pumping mechanics of the heart in in situ, open-chest experiments \[[@CR5], [@CR14], [@CR21], [@CR22]\]. Parameters generated by this model to characterize the cardiac physical processes are maximal systolic ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Enhancement technology is regarded as one of the most active fields of digital image processing. It improves the quality and appearance for low contrast image, and it can be used in monitoring, imaging systems, human-computer interaction \[[@B1]--[@B3]\], and many other areas \[... | {
"pile_set_name": "PubMed Central"
} |
Talin links integrins to the actin cytoskeleton at focal adhesions. On page 43, Morgan et al. show that talin also links synaptic activity to actin rearrangements.
FigureRings of actin (green) around synaptic vesicle clusters are lost when talin cannot bind PIPKIγ (right).
Synapses are specialized sites of cell adhes... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Stroke is one of the leading causes of morbidity and mortality worldwide. More than 80% of strokes are ischemic and are caused by obstruction of one or more cerebral arteries \[[@b1-ad-9-5-924], [@b2-ad-9-5-924]\]. Lack of blood supply deprives the brain cells of necessary glucose and o... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Uveitis is an infectious or non-infectious inflammatory disease of the uvea and other intraocular tissues including the retina, vitreous, and lens. With an incidence of more than 50/100,000-person years, uveitis is a common cause of legal blindness in the western world \[[@CR1]\]. In ... | {
"pile_set_name": "PubMed Central"
} |
Exotropia in healthy children younger than 1 year of age is rare, and several studies have been conducted on this disease entity \[[@B1][@B2][@B3][@B4][@B5][@B6][@B7]\]. Occlusion therapy alone is not sufficiently effective in reducing exodeviation, and surgery is the most promising treatment for early-onset exotropia ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Postoperative cognitive changes are a common complication, especially in elderly patients who undergo major surgeries, including arthroplasty, laparotomy, and thoracotomy with or without cardiopulmonary bypass (Saczynski et al., [@B47]; Evered et al., [@B9]). Perioperative neurocognitiv... | {
"pile_set_name": "PubMed Central"
} |
For a long time, the prediction of molecular crystal structures from first principles has been one of the most challenging computational problems. Because of the large number of degrees of freedom, methods with low computational effort have to be used. The price for this efficiency is, however, a loss of accuracy. In r... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Gastric cancer (GC) is responsible for over 1,000,000 new cases and around 783,000 deaths in the world annually, making it the 5th most frequently diagnosed cancer and the third leading cause of cancer-related death ([@ref-5]). Surgery with subsequent adjuvant chemoradiotherapy remains the on... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction
============
Public schools have an obligation to question and refute policies that do not benefit their students and their communities and a corresponding responsibility to protect students, for whom school attendance is mandated, from harm. However, implementation of change in school procedures and poli... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION: {#sec1-1}
=============
Surgical intervention to the temporal lobe caries the risk of injury to the optic radiation.\[[@ref4][@ref5][@ref6]\]. The risk of injury varies with each approach, as the extent tissue removal is different form one surgical technique to the other. During surgery it is almost impo... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The knowledge on how *BRCA1/2* mutation carriers should be counseled and treated has evolved continuously over the last two decades \[[@CR1], [@CR2]\]. Some important issues remain to be solved, though. One of these is if breast-conserving therapy (BCT) followed by postoperative radio... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Nano-sized materials have been increasingly used in the medical field to improve the target efficiency of drugs.[@b1-ijn-9-051]--[@b3-ijn-9-051] In order to successfully apply nanoparticles in drug delivery, their physical and chemical properties must first be understood, thereby assisting in... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
The treatment of end-stage chronic kidney disease includes hemodialysis, peritoneal dialysis and kidney transplantation (KTx), while today KTx is the treatment of choice due to better survival, quality of life and cost effectiveness in comparison to maintenance dialysis \[[@CR1], [@CR2]\]... | {
"pile_set_name": "PubMed Central"
} |
Correction to: Fraslin et al. Genet Sel Evol (2018) 50:60 10.1186/s12711-018-0431-9 {#Sec1}
===================================================================================
After publication of this work \[[@CR1]\], we noted that there was an error in Table 3 Line 4: ^b^Omy2~**Omy3**~ should be ^b^Omy21~**Omy3**~.
... | {
"pile_set_name": "PubMed Central"
} |
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INTRODUCTION {#s1}
============
Current treatment options for breast cancer are moving toward potent targeted therapies in general well tolerated and that can be tailored to an individual patient's tumor. There are now targeted therapeutic options available for nearly all breast cancer subtypes, exploiting the differi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-23-00346}
===============
Suramin is a water-soluble polysulfonated naphtylurea. It was first synthesized in 1916 as a colorless derivate of trypan dyes for the treatment of African trypanosomiasis (reviewed by \[[@B1-molecules-23-00346]\]). Later on it was found that suramin had an ef... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Cardiovascular diseases (CVD) are a major public health concern in the world, accounting for half of all non-communicable disease deaths worldwide \[[@B1]\]. Similar to findings from western countries \[[@B2],[@B3]\], risk factors for CVD in many developing countries have been well recognized \[[... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Biliary tract cancer (BTC) is a rare malignancy comprising a heterogeneous group of diseases including intrahepatic/extrahepatic cholangiocarcinoma and gallbladder cancer. Up to 10,000 new BTC patients are diagnosed annually in the United States and Europe \[[@b1-crt-2017-526]\]. In Korea, BT... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
*Bartonella* bacteria are new emerging pathogens causing diseases in humans and animals \[[@pone.0140856.ref001], [@pone.0140856.ref002]\]. The members of genus *Bartonella* are rod-shaped gram negative fa... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Cancer is among the most common causes of morbidity and mortality worldwide, with an estimated 14 million new cases and 8 million deaths in 2012, projected to rise by at least 70% by 2030.[@R1] Timely and accurate cancer statistics are crucial to identify priorities for cancer control strateg... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Convulsive interventions have been used to treat mental disorders since the 16th century up to the moment in the form of electroconvulsive therapy (ECT) \[[@B1]\]. The most common therapeutic indication of ECT is major depression disorder (MDD) and its effectiveness in reducing ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Facioscapulohumeral muscular dystrophy 1 (FSHD1) has an autosomal dominant pattern of inheritance \[[@CR1]\] and manifests as a consequence of both genetic \[[@CR2]--[@CR4]\] and epigenetic disease mechanisms \[[@CR5]\]. FSHD is most commonly present in the second decade of life as asymme... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Essential fatty acids (EFAs): linoleic acid (LA, n-6, 18:2) and α-linolenic acid (ALA, n-3, 18:3) form precursors to their long chain metabolites γ-linolenic acid (GLA, n-6, 18:3), dihomo-GLA (DGLA, n-6, 20:3) and arachidonic acid (AA, n-6, 20:4); and eicosapentaenoic acid (EPA, n-3, 20:5) an... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The epidemiology of methicillin-resistant *Staphylococcus aureus* (MRSA) infections has changed dramatically during the last 15 years. While traditionally MRSA was a typical example of a nosocomial pathogen, it is now frequent found as causative agent of community-associated infections ... | {
"pile_set_name": "PubMed Central"
} |
Background and Significance
===========================
Drug therapy in pediatric patients is a complex process. Children are not simply small adults, but are subject to continuous growth and variation in drug-metabolizing enzyme activity, which requires continuous adaption of dosages. Extrapolation of adult data to g... | {
"pile_set_name": "PubMed Central"
} |
I.. Introduction {#sec1}
================
Eyes and their movements are important in expressing a person\'s desires, needs and emotional states [@ref1]. The significance of eye movements with regards to the perception of and attention to the visual world is certainly acknowledged since it is the means by which the info... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-nutrients-12-01640}
===============
Fatigue is a normal sensation that serves to prompt bodily rest following physical or mental exhaustion from daily activities. However, often fatigue is not resolved adequately by rest but is aggravated owing to quality of life (QOL) deterioration. It has been... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction {#s1}
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In many organisms, early embryonic development is directed exclusively by maternal products that are deposited into the female gamete during oogenesis. Following the clearance of a subset of these products ([@bib95]), transcription is initiated and the zygotic genome acquires developmen... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction
============
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide.[@B1], [@B2] CRC is caused by mutations that target oncogenes, tumor suppressor genes and genes related to DNA repair mechanisms. Interestingly, noncoding RNAs account fo... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Fruit ripening involves the well-orchestrated coordination of several regulatory steps in both climacteric and non-climacteric fruit, together with strong metabolic and physiological changes ([@CIT0025]). Fig fruit (*Ficus carica*) are categorized as climacteric; they show a rise in res... | {
"pile_set_name": "PubMed Central"
} |
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Background {#Sec1}
==========
Over the past 20--30 years, suicide rates have declined overall in European countries with previously high rates of suicide, such as Denmark, Estonia, Germany, Hungary, and Sweden \[[@CR1]\]. Ever since the adoption of a national suicide prevention strategy in 2008, \[[@CR2]\] the suicide... | {
"pile_set_name": "PubMed Central"
} |
By 2030, 72.1 million people in the USA will be 65 years or older and will represent 20% of the US population, expanding the need for speech-language pathology services while increasing costs ([@b1-ijt-09-25]). Not only are demographics changing, but people are also experiencing extended work days reducing the capacity... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Autoinflammatory syndromes are an incompletely understood spectrum of diseases that involve spontaneous inflammation caused by genetic variants of the innate immune system. Unlike autoimmune diseases, no high-titer autoantibodies are associated with the disease process. We report a ca... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In paediatric palliative care (PPC), most seriously ill children are predominantly cared for at home \[[@CR18], [@CR31], [@CR43]\]. Therefore, parents of a child with a life-limiting disease (LLD) are confronted with increased caregiving demands, and also have to cope with the inevita... | {
"pile_set_name": "PubMed Central"
} |
Many cancer cells are addicted to driver oncogenes or to cancer-selective survival factors, and their proliferation and survival is highly dependent on oncogenic signaling pathways.[@b1],[@b2] Therefore, molecularly targeted drugs that selectively inhibit these pathways are critically important for the pharmacological ... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
The cellular and molecular mechanisms that underlie protein misfolding are a matter of major concern for studies conducted in several scientific centers all over the world. Under denaturing conditions, a g... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Aerosol delivery of therapeutic gene is made directly to the respiratory tract without first delivery to other organs and tissues. Due to these advantages, many studies have been applied to gene therapy for lung disease, such as lung cancer ([@B1]), asthma ([@B2]) and chronic obstructive pulm... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
It was reported that fetal mortality rate at 20 weeks of gestation or more was 6.22 deaths per 1,000 in United States, in which the fetal mortality rate for twins was 2.7 times higher compared to singletons [@pone.0065050-MacDorman1]. The higher risk of twin pregnancies may due to sever... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
Acetaminophen-induced toxicity, like many other drugs, may have a great deal of variations at the molecular, cellular, tissue, organ and organism levels \[[@pone.0145965.ref001]--[@pone.0145965.ref002]\]. Metabolic alterations and increased o... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Illegal, unreported, and unregulated (IUU) fishing undermine efforts to sustainably manage fish stocks and threaten fish populations worldwide \[[@pone.0143960.ref001]\]. Managers must know as much as poss... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The pendulum of scientific opinion often swings back and forth in the light of new data and hypotheses. 150 years ago Darwin\'s observations pushed opinion towards believing the universal tree of life (TOL) existed for the first time \[[@B1]\]. This view was pushed to an extreme 30 years ago as W... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Neurosensory symptoms, such as tinnitus and dizziness, are frequently observed in elderly people and even more so in patients with dementia. Five-year and 10-year incidence rates of 18.0% and 12.7% were reported for tinnitus from the Blue Mountains Hearing Study and the Beaver Dam Epidemiolog... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
It was estimated that over 2.2 billion participants worldwide are at risk of iodine deficiency. Iodine deficiency remains a major public health problem \[[@CR1], [@CR2]\]. Understanding the role of risk factors is key to developing a clear and effective strategy for improving global healt... | {
"pile_set_name": "PubMed Central"
} |
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