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Related literature {#sec1} ================== For applications of cyclams, see: Lindoy (1992[@bb15]); Izatt *et al.* (1991[@bb13], 1995[@bb12]); Enoki *et al.* (2003[@bb6]); Steward & McLaughlin (2004[@bb24]); Sibert (2002[@bb21]); Volkert & Hoffman (1999[@bb25]); Anderson & Welch (1999[@bb1]); Caravan *et al.* (1999[...
{ "pile_set_name": "PubMed Central" }
During most of the 20th century, biopharmacologic products, including vaccines, prophylactic serum, blood flasks, and animal-origin waste, were buried [\<]{.ul}1.5 m deep in the 12,000-m^2^ waste dump of a pharmaceutical research institute in Milan (Istituto Sieroterapico Milanese \[ISM\]). ISM was founded in 1886 but ...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Malarial infection of humans is a major cause of morbidity and mortality, continuing to cause around 250 million cases and close to a million deaths annually [@pcbi.1000946-Organisation1]. The vast majority of severe cases and deaths are due to *Plasmodium falciparum*, which is endemic ...
{ "pile_set_name": "PubMed Central" }
Introduction {#section1-2324709619872657} ============ Acute myeloid leukemia (AML) is a heterogeneous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. Trisomy 8 (+8) is one of the most common numerical chromosome abnormalities reported ...
{ "pile_set_name": "PubMed Central" }
![](indmedgaz71206-0047){#sp1 .31} ![](indmedgaz71206-0048){#sp2 .32}
{ "pile_set_name": "PubMed Central" }
1.. Introduction ================ Soft sensors are frequently used for on-line estimations based on analysis of measurement signals from hardware sensors with software implemented mathematical models ([Figure 1](#f1-sensors-14-17864){ref-type="fig"}) \[[@b1-sensors-14-17864],[@b2-sensors-14-17864]\]. Typically, the mo...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ During adverse conditions like oxidative stress, heat shock, DNA damage, osmotic imbalances and nutrient limitation, eukaryotic cells defend themselves by activating the expression of several genes involved in repair and prevention of the damage caused by such stimuli ([@BIO053322C31]; ...
{ "pile_set_name": "PubMed Central" }
The standard human reference (currently GRCh38), which is mostly based on Caucasian and African ancestry[@b1][@b2], is accurate, precise and extensive. Because of the relatively small long-term effective population size of anatomically modern humans (estimated to be as small as ∼10,000)[@b3][@b4], such a reference is a...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ The management of diabetes mellitus requires an accurate evaluation of blood glucose control to assess the efficiency of a particular therapy. Whole blood hemoglobin A1c (HbA1c) measurements have been widely used in diabetes patients for more than 25 years to monitor long‐term glycemic contro...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Ovarian cancer is the leading cause of death from gynaecologic cancer, and it is estimated that 22,280 new diagnoses and 14,240 deaths from this neoplasm will occur in United States in 2016 \[[@R1]\]. Standard treatment is platinum (Pt)-based chemotherapy and surgical debulking of the t...
{ "pile_set_name": "PubMed Central" }
Introduction {#section3-2055116915621582} ============ Cats with neoplasia often show unspecific clinical signs of chronic disease such as anorexia and weight loss. Paraneoplastic alopecia is predominantly present on the ventral abdomen and hindlimbs. Characteristic for paraneoplastic alopecia is smooth and shiny skin...
{ "pile_set_name": "PubMed Central" }
Human rights have been central to the global response to the HIV pandemic, providing a legal foundation for social, political and institutional efforts to protect vulnerable individuals and fulfil government obligations. As medical advances bring the world closer to a clinical cure, new rights-related issues are emergi...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Time to flowering and maturation influences the productivity, adaptability, and quality of seed crops. Flowering time is determined by the integration of signals from external stimuli (such as photoperiod and temperature) and internal conditions (such as plant age and the amount of gibb...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-ijerph-17-04613} =============== In May 2015, the Pan American Health Organization issued an alert reporting the first confirmed Zika virus infection in Brazil. Subsequently, on 1 February 2016, the World Health Organization (WHO) declared that a massive Zika virus outbreak in the Americas was a...
{ "pile_set_name": "PubMed Central" }
Background ========== In 1953, James Watson and Francis Crick published the structure of DNA \[[@B1]\], for which they were awarded a Nobel Prize in 1962. They determined that DNA consists of two antiparallel, complementary strands twisted around each other to form a right-handed double helix held in place by interact...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== In the last decades, the rate of pregnancies at an advanced maternal age (AMA) has increased steadily \[[@CR1]--[@CR3]\]. In most studies addressing this issue, AMA is defined as maternal age above 35 years, considering very advanced maternal age (VAMA) 40 years or more and extremely adva...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ *Penicillium* sect. *Chrysogena* was introduced by [@R14] for species having ter- or quarterverticillate branched conidiophores, relatively short phialides (\< 10 μm) and smooth to finely roughened conidia. Four series and eight species (*P. aethiopicum, P. chrysogenum, P. confertum, P....
{ "pile_set_name": "PubMed Central" }
Introduction ============ Cancer is now recognized as a systematic disease rather than a solo abnormality. Different types of benign cells surround the milieu of a tumor and actively facilitate malignant progression in a three-dimensional structure.[@cit1] It is an increasingly recognized fact that tumor micro-environ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Prostate cancer is one of the most common cancers in men \[[@B1]\]. Androgen deprivation therapy (ADT) is a mainstay treatment of metastatic or advanced prostate cancer and has been shown to improve overall survival \[[@B2][@B3]\]. However, luteinizing hormone-releasing hormone analogue (LHRH...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-materials-13-03197} =============== Cancer shows the highest mortality rate worldwide, which is due in part to mutations that enable cancer cells to survive and spread to other organs \[[@B1-materials-13-03197]\]. Approximately 40% of patients with lung cancer worldwide die within one year of di...
{ "pile_set_name": "PubMed Central" }
Introduction and Initial Observations {#s1} ===================================== Over many centuries and even millennia, numerous accounts have attested that imbibing arsenicals was a powerful means of poisoning as well as a purported remedy for treating many diseases ([@B1]--[@B4]). Arsenic first appeared in Western...
{ "pile_set_name": "PubMed Central" }
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ene.14383
{ "pile_set_name": "PubMed Central" }
The data on which the IPD and pertussis capture-recapture studies are based consist of case records. Due to privacy issues the data owners have to be contacted before anonymized data can be obtained. Contact details were provided to PLOS ONE. IPD hospital study - <Annick.Mignon@pfizer.com> IPD national reference center...
{ "pile_set_name": "PubMed Central" }
###### Kunduz hospital bombing Health workers in one of the remaining parts of the Médecins Sans Frontières (MSF) Trauma Centre in Kunduz, Afghanistan after it was bombed on 3 October. At least 22 people died including 12 MSF staff and 10 patients. <http://www.msf.ch/> ![](BLT.15.011115-Fa){#Fa} Call to action on cl...
{ "pile_set_name": "PubMed Central" }
Related literature {#sec1} ================== For background on metal azo complexes, see: Carella *et al.* (2007[@bb2]); Kulikovska *et al.* (2007[@bb8]); Patnaik *et al.* (2007[@bb11]); Leng *et al.* (2001[@bb9]). For bond lengths, see: Abildgaard *et al.* (2006[@bb1]). For hydrogen bonds, see: Jeffrey & Saenger (199...
{ "pile_set_name": "PubMed Central" }
Background ========== Although nasopharyngeal carcinoma (NPC) is rare in most of the world, it is endemic in certain regions, especially Southeast Asia. The incidence of NPC in Southern China is approximately 30 to 80 per 100,000 people per year \[[@B1]\]. Newly diagnosed NPC without distant metastasis is typically tr...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Multivesicular body (MVB) formation, cytokinesis, and viral budding are membrane deformation events that share a common topology by pushing membrane away from the cytosol. The ESCRT machinery is evolutionarily conserved across eukaryotes and consists of five complexes: ESCRT-0 (mediates clust...
{ "pile_set_name": "PubMed Central" }
![](envhper00480-0298.tif "scanned-page"){.315} ![](envhper00480-0299.tif "scanned-page"){.316} ![](envhper00480-0300.tif "scanned-page"){.317} ![](envhper00480-0301.tif "scanned-page"){.318} ![](envhper00480-0302.tif "scanned-page"){.319}
{ "pile_set_name": "PubMed Central" }
Depression, psychosis and bipolar disorders are three of the four most burdensome conditions in young people aged under 25 years.^[@r1]^ Furthermore, these three major mental disorders all demonstrate a peak age at onset of between 15 and 25 years.^[@r2]^ Evidence clearly indicates that individuals at clinical high ris...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-ijerph-17-01730} =============== The global demand for water resources keeps increasing and water pollution problems will continue to worsen \[[@B1-ijerph-17-01730]\]. In order to cope with the increasingly severe water crisis, the Chinese government has actively advocated the construction of a ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ End-stage knee osteoarthritis (OA) is one of the most common debilitating diseases and is a leading cause of pain, stiffness, edema, disability, and functional limitation in older adults[@r1],[@r2],[@r3]^)^. Several studies have reported that when patients with end-stage knee OA are ask...
{ "pile_set_name": "PubMed Central" }
*Disclosures of potential conflicts of interest may be found at the end of this article*. Introduction {#onco13189-sec-0006} ============ The evolving landscape for prevention of chemotherapy‐induced nausea and vomiting (CINV) now includes an armamentarium of antiemetic agents, with the standard of care for highly (H...
{ "pile_set_name": "PubMed Central" }
As a codirector of the Resiliency Center at the University of Utah, I spend a lot of time talking about the epidemic of burnout in health care. Recently, I had lunch with a group of first-year medical students just starting their medical career, and our conversation turned to burnout and the state of medicine. One of t...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Alcohol use among young people is a significant public health problem given its adverse consequences to health and well-being in youth and later in life.^[@r01]^ Although the prevalence of adolescent alcohol use in many countries including Japan has been declining,^[@r01],[@r02]^ it still rem...
{ "pile_set_name": "PubMed Central" }
Introduction ============ *Wolbachia*, alphaproteobacterial endosymbionts, are widespread and common in arthropods and filarial nematodes, either as reproductive parasites or mutualists ([@evz223-B35]; [@evz223-B14]; [@evz223-B36]). About half of arthropods are infected with *Wolbachia* ([@evz223-B15]; [@evz223-B38]) ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Calcium is a universal intracellular signaling agent involved in a myriad of processes from fertilization to cell death ([Berridge et al. 1998](#Berridgeetal1998){ref-type="bib"}). Changes in cytosolic free calcium (\[Ca^2+^\]~i~) are well documented for cells stimulated by many hormone and g...
{ "pile_set_name": "PubMed Central" }
Introduction {#s0} ============ Pemphigus vulgaris is a potentially life-threatening disease that causes blisters and erosions of the skin and mucous membranes. These epithelial lesions are the result of autoantibodies. The immune reaction against these autoantibodies primarily affects the mucous membranes of patients...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ The bone marrow microenvironment, which determines the fates of bone-resorbing osteoclasts and bone forming-osteoblasts, is an important region for bone metabolism ([@B1]). Osteoclasts, which are derived from monocyte/macrophage lineages, are regulated primarily by receptor activator of...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ The efficiency of the separation process in reversed-phase HPLC is highly dependent on the binary hydro-organic mobile phase composition and surface properties of the packing material. The high progress in increasing the efficiency of separations of various analytes has been achieved ...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1-1} ============ Diabetic neuropathy is a common microvascular complication of diabetes mellitus. Symptoms of diabetic neuropathy range from mild dysesthesias to severe unremitting pain that can profoundly affect the quality of life.\[[@ref1][@ref2]\] Neuropathic pain in diabetes is defined as pain ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Soil is an essential natural resource for human being, and management practices can significantly influence the land productivity and change soil properties. For example, intensive management of *Phyllostachys praecox* bamboo forests has shown to result in accumulation of nitrog...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ It is widely accepted that a complete infertility workup should include an evaluation of the uterine cavity. Uterine abnormalities, congenital or acquired, are implicated as one of the causes of infertility. In fact, infertility related to uterine cavity abnormalities has been estimated to be...
{ "pile_set_name": "PubMed Central" }
![](envhper00432-0092.tif "scanned-page"){.91} ![](envhper00432-0093.tif "scanned-page"){.92} ![](envhper00432-0094.tif "scanned-page"){.93} ![](envhper00432-0095.tif "scanned-page"){.94} ![](envhper00432-0096.tif "scanned-page"){.95} ![](envhper00432-0097.tif "scanned-page"){.96} ![](envhper00432-0098.tif "scann...
{ "pile_set_name": "PubMed Central" }
Background ========== The traditional diagnostic approach for focal neuropathies involves a detailed history and physical examination, augmented by electrodiagnostic studies (nerve conduction studies and electromyography). \[[@B1]\] While this approach is effective for localizing the site of pathology and determining ...
{ "pile_set_name": "PubMed Central" }
Introduction ============ ELISA (Echelle Liégeoise d\'Index de Sévérité à l\'Admission) is a valid new Emergency Department (ED) triage algorithm including five levels of categorisation (from U1, high emergency degree, to U5, low degree), based on vital signs and selected anamnestic data. Previous work has demonstrate...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Autoinflammatory disorders (AIDs) represent an expanding group of complex diseases characterized by periodic or chronic systemic inflammations. Mutations in more than 15 geneshave been associated with autoinflammatory recessive or dominant syndromes. Next Generation Sequencing (NGS) has emerg...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Since the mid-1990s, the number of completely sequenced bacterial genomes has grown to more than 1350 and many more are in progress (<http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi>). These efforts have provided a vast amount of information regarding gene content, and thus the physi...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-ijerph-17-01132} =============== Participation in sufficient physical activity during the early years is an important ingredient in healthy childhood development \[[@B1-ijerph-17-01132],[@B2-ijerph-17-01132],[@B3-ijerph-17-01132]\]. Early years providers, individuals who work in the early childh...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Independent component analysis (ICA) [@pone.0073309-McKeown1]--[@pone.0073309-Cardoso1] is a widely used signal processing approach that has been applied to areas including speech separation, communications, and functional magnetic resonance (fMRI) data analysis. Given a set of linearly...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#s1} =============== Neuroergonomics is an emerging field of interdisciplinary research that promotes the understanding of the brain in complex real-life activities. This approach merges knowledge and methods from cognitive psychology, system engineering, and neuroscience (Parasuraman and Wilson, [@B6...
{ "pile_set_name": "PubMed Central" }
Introduction {#section1-1559325819883479} ============ Despite technological advances in radiotherapy, radiation-induced toxicity in previously healthy tissues remains a serious concern. The current radiotherapy techniques expose both healthy tissues and tumors to a wide range of dose sizes and fractionations, with a ...
{ "pile_set_name": "PubMed Central" }
Background {#sec1-1} ========== Populations are ageing and older adults make an increasing contribution to society, yet uncorrected hearing loss is common over the age of 50 years, increasing in prevalence and severity with age. The consequences of uncorrected hearing loss can be profound for hearing-impaired individu...
{ "pile_set_name": "PubMed Central" }
![](indmedgaz72188-0009){#sp1 .251} ![](indmedgaz72188-0010){#sp2 .252} ![](indmedgaz72188-0011){#sp3 .253} ![](indmedgaz72188-0012){#sp4 .254} ![](indmedgaz72188-0013){#sp5 .255} ![](indmedgaz72188-0014){#sp6 .256} ![](indmedgaz72188-0015){#sp7 .257} ![](indmedgaz72188-0012-a){#f1 .254}
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Lymphedema is a chronic disease provoked by damage or abnormalities affecting the lymphatic system that cause increased limb volume. It affects around 15% of the global population.[@B001] ^,^ [@B002] Lower limb (LL) lymphedema is the most prevalent presentation, accounting for 80% of cases.[@...
{ "pile_set_name": "PubMed Central" }
1. Development of Research Facilities for the Study of Viral Hemorrhagic Fevers =============================================================================== The International Centre for Medical Researches of Franceville (CIRMF) was founded in 1974 by His Excellency El Hadj Omar Bongo Ondimba, President of the Gabon...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Combined tracheostomy and thyroidectomy is usually done in case of removal of a large goiter that causes damage to the anterior tracheal wall \[[@bib1]\]. Multiple studies have established criteria which patients need a tracheostomy due to tracheomalacia \[[@bib2],[@bib3]\]. Nev...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with high morbidity and mortality, and is common in elderly people. This disease affects up to 8-10% of men over the age of 65 years and its prevalence is predicted to increase in parallel with the global ageing populati...
{ "pile_set_name": "PubMed Central" }
{#ejh13479-ltr-0001} To the Editor, {#ejh13479-sec-0001} Following the emergence of COVID‐19 as a global pandemic, cancer clinicians have been faced with the challenge of continuing to manage patients, with limited data to inform practice.[^1^](#ejh13479-bib-0001){ref-type="ref"} Recently, a largeprospective cohor...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-molecules-25-02705} =============== Launching new active pharmaceutical ingredients (APIs) in the market is expensive, time consuming, and requires the use of complex production processes. Alternatively, pharmaceutical companies started developing strategies to improve the efficacy of well-known...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Over the last three decades, there has been a general shift from public services to a marketisation of public goods and services \[[@CR1]-[@CR8]\]. A market is the organisation through which the consumption and production of goods and services takes place through voluntary exchanges \[[@C...
{ "pile_set_name": "PubMed Central" }
Background and Significance =========================== Inflammatory Bowel Disease (IBD) is a multifactorial disorder for which a complete etiology is not yet known, but which occurs in response to the convergence of genetic predisposition towards disease development, intestinal microbiota, external environmental fact...
{ "pile_set_name": "PubMed Central" }
Introduction {#s0005} ============ Esophageal cancer, including esophageal squamous cell carcinoma and esophageal adenocarcinoma, is the sixth leading cause of cancer-related death and the eighth most frequently diagnosed cancer in the world ([@bb0095]). In 2014, 18,170 new cases, which led to approximately 15,450 dea...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Emission of herbivore-induced volatiles (HIPVs) in response to herbivore feeding damage has been studied intensively during the past two decades. Recently, a relatively small but growing number of investigations have revealed that oviposition can induce production of plant volatiles t...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Stroke is one of the three leading causes of death in South Korea and its incidence is gradually increasing. Specifically, with a mortality of 48.2 persons per 100,000 population in 2014, stroke was the 3rd most common cause of death[@r1]^)^. In stroke patients, impaired visual percepti...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Gastrointestinal (GI) submucosal tumors (SMTs) are not rare, and with increasing use of esophagogastroduodenoscopy and improvement of diagnostic modalities, they are estimated to increase. Gastrointestinal stromal tumor (GISTs) are the most common among SMTs of the stomach, which usually cons...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Mobile DNA sequences known as transposable elements are naturally occurring mutagenic agents that have been harnessed as experimental tools for genetic analysis in a variety of model organisms ([@B1],[@B2]). Of the two major classes of transposable elements that exist---those that transpose d...
{ "pile_set_name": "PubMed Central" }
Javadiyan S, Lucas SEM, Wangmo D, et al. Identification of novel mutations causing pediatric cataract in Bhutan, Cambodia, and Sri Lanka. Mol Genet Genomic Med. 2018;6:555--564. 10.1002/mgg3.406 1. INTRODUCTION {#mgg3406-sec-0005} =============== Pediatric cataract (including congenital cataract) is an opacity of the...
{ "pile_set_name": "PubMed Central" }
Some notable names in renal medicine from the sixteenth to the nineteenth century. **ABERCROMBIE John** (1780--1844) Fellow of the Royal College of Surgeons of Edinburgh. Abercrombie moved from successful general practice into the Royal Public Dispensary as a consultant and was appointed physician to the King in Scot...
{ "pile_set_name": "PubMed Central" }
Original article: Aging (Albany NY) 2017; 8(11): 3131-3146. PMCID: PMC 5191890 PMID: 27922819 doi: 10.18632/aging.101120 Please check the link to the original paper: <http://www.aging-us.com/article/101120/text> **Present:** Due to an omission of three authors, the list of authors is incomplete. **Corrected:** Addi...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ *Dissoconium*, an anamorphic genus based on the type species *Dissoconium aciculare* ([@R34]), is known to have different ecological niches. Two species, *D. aciculare* and *D. dekkeri*, were reported as mycoparasitic fungi on *Erysiphaceae* ([@R34], [@R33]). However, recent studies sho...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Pain is a critical component of patient management that often not only consists of physical disability but also necessitates care to address the psychological, emotional, and economic strain it places on patients and their caretakers. It places a significant economic strain on society in the ...
{ "pile_set_name": "PubMed Central" }
All raw reads files are available from the NCBI (SRA) database (accession number SRP131560). Introduction {#sec001} ============ Rice is a crucial agronomic crop worldwide, especially in Asians. By the year 2030, a 40% increase in rice production will be necessary to accommodate the rapidly increasing world populatio...
{ "pile_set_name": "PubMed Central" }
Songbirds are vocal learners and have been used as animal models for speech acquisition and production[@b1][@b2]. Auditory feedback (AF) is required for normal speech development and maintenance in humans[@b3][@b4][@b5]. In songbirds, AF is necessary for song development[@b6][@b7][@b8] and adult song maintenance as dem...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Nonalcoholic fatty liver disease (NAFLD), one of the most common liver diseases worldwide^[@CR1]^, is strongly associated with insulin resistance and features of metabolic syndrome such as obesity, hyperlipidemia, and type 2 diabetes^[@CR1],[@CR2]^. NAFLD ranges from simple steatosis ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec0005} =============== Licorice is a well-known Chinese herb, which has been used in food and medicinal remedies for thousands of years.[@bib0005] Licorice has been the most important ingredient of Chinese traditional medicine since ancient times, and is prescribed in 60% of all cases.[@bib0010] It...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Current knowledge widely indicates a direct relationship between anthropogenic pressures and the deteriorating environmental state and/or global extinction of amphibian populations (Blaustein and Johanson [@CR4]; Collins and Storfer [@CR10]; Stuart et al. [@CR60]). Negative impacts in...
{ "pile_set_name": "PubMed Central" }
![](edinbmedsurgj71834-0116){#sp1 .244} ![](edinbmedsurgj71834-0117){#sp2 .245} ![](edinbmedsurgj71834-0118){#sp3 .246} ![](edinbmedsurgj71834-0119){#sp4 .247} ![](edinbmedsurgj71834-0120){#sp5 .248} ![](edinbmedsurgj71834-0121){#sp6 .249}
{ "pile_set_name": "PubMed Central" }
2. Background ============= Fibromyalgia (FM) is characterized by generalized tenderness and chronic widespread pain that affects 2-4% of the population in industrialized nations and primarily affects females \[[@B1]\]. Although its etiology and pathogenesis are largely unknown, emerging evidence indicates that pain a...
{ "pile_set_name": "PubMed Central" }
All the images are available from the Set5 \[30\], Set14 \[31\] database. Introduction {#sec001} ============ Image super-resolution (SR) arms to reconstruct a high resolution (HR) image from a single or several low resolution (LR) image of the scene together \[[@pone.0201463.ref001]--[@pone.0201463.ref005]\]. The re...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-plants-09-00409} =============== Flax (*Linum usitatissimum* L.) is one of the oldest annual crops and presents numerous benefits to human health \[[@B1-plants-09-00409],[@B2-plants-09-00409],[@B3-plants-09-00409],[@B4-plants-09-00409],[@B5-plants-09-00409]\]. Its average production of 1.6 milli...
{ "pile_set_name": "PubMed Central" }
Background ========== Much of the detailed phenotypic information that is necessary for translational research is only available in clinical note documents and the breadth of clinical information that can be extracted from these documents is profound. Over the last decade researchers have employed a variety of methods...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Organophosphorus (OP) compounds such as pesticides are typically symmetric around the phosphorus center, while chemical warfare nerve agents (CWNAs) possess a chiral center about the phosphorus. Lethal exposure to a CWNA results in irreversible inhibition of the acetylcholinesterase (AChE) en...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Despite global efforts against malaria, it is still one of the health challenges worldwide, based on WHO report, about 212 million cases of disease occurred globally (range 148--304 million), with 429 000 deaths (range 235000--639000) ([@B1]). Among five *Plasmodium* species, which cause mala...
{ "pile_set_name": "PubMed Central" }
Percutaneous nephrolithotomy (PCNL) is a minimally invasive treatment for renal stones. It is associated with varied complications such as hemorrhage, pyelonephritis, perinephric abscess or urinoma, hemothorax, pneumothorax, colonic injury, and rarely death.\[[@ref1]\] The post-PCNL phantom hernia is a rare complicatio...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ The global elderly population is steadily increasing, including in China. In total, 131 million Chinese were aged over 65 years by the end of 2013, representing about 9.6% of the total population (<http://data.stats.gov.cn>). The Chinese Academy of Social Sciences has predicted that China wil...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-sensors-20-03030} =============== Applications of superparamagnetic, micron-sized particles, often called magnetic beads (MBs), have proliferated in the last two decades, most notably in fields related to biomedical science and technology. These materials pose multiple advantages, including but ...
{ "pile_set_name": "PubMed Central" }
Background ========== With the rapid development of technologies, more and more single-nucleotide polymorphisms (SNPs) have become available and, in particular, most of the rare variants can be identified using the next-generation sequencing technique. However, detecting associated rare variants that contribute to phe...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ Cancer is primarily a genetic disease, and aberrations in the DNA sequence and expression of multiple genes in cancer cells have been detected. Although many studies have identified the candidate genes tha...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1} ============ Sulfoquinovose is found in the ubiquitous plant sulfolipid α-[d]{.smallcaps}-sulfoquinovosyl diacylglyceride (SQDG), which is one of the most abundant organic sulfur compounds in nature.^[@ref1]^ SQDG is produced by most photosynthetic organisms and forms an integral part of the thyla...
{ "pile_set_name": "PubMed Central" }
Napoleon Cybulski was born on September 14, 1854, in Krzywonose, which was then in Polish territory under Russian tsaristic rule. He came from a noble family. After grammar school in Minsk, he started medical studies in Petersburg at the Military Medical Academy. In 1880 he received a diploma in medicine *cum exima lau...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Abdominal aortic aneurysm (AAA) is a severe, devastating large artery disease that leads to a high mortality and morbidity, particularly when complicated by aortic rupture \[[@CR1]\]. Surgery remains the first-line treatment for AAA, however, postoperative AKI is a major complication asso...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-sensors-18-04033} =============== Human locomotion is a complex mechanism composed of a succession of strides, steps, and phases \[[@B1-sensors-18-04033],[@B2-sensors-18-04033]\]. Some pathologies (such as Parkinson's disease, arthritis, stroke, obesity, diabetes, etc.) may alter the locomotion,...
{ "pile_set_name": "PubMed Central" }
**Core tip:** Our retrospective study highlights the intensive care unit (ICU) management, complications and outcomes of patients undergoing complicated hyperthermic intraperitoneal chemotherapy procedure for peritoneal carcinomatosis. Intensivists need to monitor for physiologic derangements post procedure and assess ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-jcdd-05-00035} =============== Renal disease results in accelerated atherosclerosis and increased morbidity and mortality, mainly for cardiovascular causes due either to uremia-related risk factors, such as anemia, hyperparathyroidism, inflammation, oxidative stress and malnutrition \[[@B1-jcdd-...
{ "pile_set_name": "PubMed Central" }
Taylor, A. E., Davey Smith, G., and Munafò, M. R. (2018) Associations of coffee genetic risk scores with consumption of coffee, tea and other beverages in the UK Biobank. Addiction, 113: 148--157. doi: [10.1111/add.13975](10.1111/add.13975).28793181 Introduction {#add13975-sec-0008} ============ Genome‐wide associati...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ The Nigerian health care system, like in some other developing countries, is bedeviled with poor health indices and service delivery to majority of the population.[@ref1] The Nigerian public health system is characterized by grossly ill-equipped facilities [@ref2] as well as inadequ...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Betanodavirus infection causes viral nervous necrosis (VNN) in fish, which is an infectious neuropathological condition characterized by necrosis of the central nervous system, including the brain and retina \[[@CR1]\]. Clinical signs include abnormal swimming behavior and darkening o...
{ "pile_set_name": "PubMed Central" }
Background ========== DNA microarray technologies are powerful tools that can be used to quantify differences in the amount of specific DNA or RNA sequences between samples. Recently, application of this technology has extended to the measurement of changes in the abundance of microRNAs (miRNA). MiRNAs are a class of ...
{ "pile_set_name": "PubMed Central" }