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### Question: Is self-reported obstructive sleep apnea associated with nonresponse to antidepressant pharmacotherapy in late-life depression? ### Context: Obstructive sleep apnea (OSA) is frequently comorbid with late-life depression. The purpose of this project was to determine, using a sample of older adults with maj... |
### Question: Is inflammatory bowel disease associated with an increased risk of lymphoma? ### Context: Previous studies of the risk of lymphoma in inflammatory bowel disease patients have provided conflicting results. This study examines the risk of Hodgkin's and non-Hodgkin's lymphoma among patients with inflammatory... |
### Question: Is phenoxybenzamine more effective and less harmful than papaverine in the prevention of radial artery vasospasm? ### Context: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial ar... |
### Question: Definitive chemoradiation for non-small-cell lung cancer: could a consensus be reached? ### Context: There is currently no consensus as to which chemotherapy to combine with thoracic radiotherapy (TRT) in the setting of definitive chemoradiation for non-small-cell lung cancer (NSCLC). We aimed to retrospe... |
### Question: Is lower white matter microstructure in the superior longitudinal fasciculus associated with increased response time variability in adults with attention-deficit/ hyperactivity disorder? ### Context: Response time variability (RTV) is consistently increased in patients with attention-deficit/hyperactivity... |
### Question: Are cerebral microbleeds a risk factor for warfarin-related intracerebral hemorrhage? ### Context: Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated wi... |
### Question: The evolution of faculty development in Canada since the 1980s: coming of age or time for a change? ### Context: The roles and responsibilities of faculty members at Canadian medical schools are changing significantly as a consequence of influences such as the competency dictates outlined in the CanMEDS r... |
### Question: Do angiotensin converting enzyme inhibitors attenuate ischemic brain metabolism in hypertensive rats? ### Context: Angiotensin converting enzyme (ACE) inhibitors are expected to modulate neuronal activities. The present study was designed to examine the beneficial effects of ACE inhibitors on microcircula... |
### Question: Is posttransplant nephrocalcinosis associated with poor renal allograft function : a single-center experience? ### Context: Nephrocalcinosis, characterized by intratubular and/or parenchymal deposition of calcium phosphate and calcium oxalate crystals, is frequently seen in renal allograft biopsies; howev... |
### Question: Does epidural sufentanil provide better analgesia from 24 h after surgery compared with epidural fentanyl in children? ### Context: Studies comparing epidural fentanyl and sufentanil in adults reported a similar analgesic effect with variable side effects. We hypothesized that epidural fentanyl and sufent... |
### Question: Do Patients With Chronic Low Back Pain Benefit From Early Intervention Regarding Absence From Work? ### Context: A randomized, controlled, single-center pilot study.The aim of this study was to investigate the feasibility of running a trial to explore if early intervention in individuals with chronic low ... |
### Question: Does undetectable postoperative cortisol always predict long-term remission in Cushing 's disease : a single centre audit? ### Context: An undetectable postoperative serum cortisol has been regarded as a definition of cure in Cushing's disease. However, we noted disease recurrence amongst patients with Cu... |
### Question: Does selective COX-2 Inhibition exert No Negative Effects on Peripheral Blood Lymphocytes in Allergic Asthmatics? ### Context: Selective inhibition of cyclooxygenase-2 (COX-2) reduces the production of prostaglandin E2 (PGE2), which can have both pro- and anti-inflammatory effects on allergic inflammation... |
### Question: Does toll-like receptor 7 stimulation promote autoimmune diabetes in the NOD mouse? ### Context: The role of Toll-like receptor 7 (TLR7), a sensor of viral and self RNA, in promoting autoimmune diabetes remains unclear. Our goal was to determine the effect of TLR7 stimulation on the priming and activation... |
### Question: Colorectal cancer screening in women with endometrial cancer: are we following the guidelines? ### Context: Colorectal cancer (CRC) is the most common gastrointestinal malignancy. There is an association between CRC and endometrial cancer (EC). Up to 10% of this linkage may be due to hereditary non-polypo... |
### Question: Is increased estrogen-dependent expression of calcineurin in female SLE T cells regulated by multiple mechanisms? ### Context: Calcineurin is a key mediator of T cell activation. Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in calcineurin expression in the T cel... |
### Question: Are sleep Problems Associated With Chronic Pain Over and Above Mutual Associations With Depression and Catastrophizing? ### Context: Pain, mood problems, and sleeping difficulties are often comorbid and contribute to reduced physical function and quality of life for those with chronic pain. However, the w... |
### Question: Are children reliable reporters of common symptoms : results from a self-reported symptom diary for primary school children? ### Context: Collecting information on subjective symptoms in children by parental reports or physician's interview is indirect and not suited for prospective data collection over e... |
### Question: Is the severity of nauseogenic effect of cross-coupled rotation proportional to gyroscopic angular acceleration? ### Context: Subjects underwent cross-coupled rotation of the head (i.e., Coriolis stimuli) during which the upper body was tilted from side to side during horizontal rotation of the whole body... |
### Question: Sympathetic ophthalmitis following vitreoretinal surgery: Does antecedent trauma make a difference? ### Context: Sympathetic ophthalmitis (SO) has been reported following vitrectomy; however, there is a lack of data on the role of antecedent penetrating ocular trauma impacting the disease manifestation in... |
### Question: Do synovial concentrations of the angiogenic peptides bFGF and VEGF discriminate rheumatoid arthritis from other forms of inflammatory arthritis? ### Context: To investigate whether concentrations of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in aspirated synovial ... |
### Question: Does early statin therapy restore endothelial function in children with familial hypercholesterolemia? ### Context: This study was designed to determine whether simvastatin improves endothelial function in children with familial hypercholesterolemia (FH).Endothelial function measured by flow-mediated dila... |
### Question: Does adenosine A1 receptor antagonism hasten the decay in ventricular fibrillation waveform morphology during porcine cardiac arrest? ### Context: Endogenous adenosine (ADO) is known to be cardioprotective during acute myocardial ischemia. Coronary sinus ADO concentration has recently been shown to increa... |
### Question: Is upper tract imaging surveillance effective in diagnosing upper tract recurrence in patients followed for nonmuscle invasive bladder cancer? ### Context: We evaluated the usefulness of routine upper tract imaging in patients followed for nonmuscle invasive bladder cancer.A retrospective review of patien... |
### Question: Do lactobacillus ruminis strains cluster according to their mammalian gut source? ### Context: Lactobacillus ruminis is a motile Lactobacillus that is autochthonous to the human gut, and which may also be isolated from other mammals. Detailed characterization of L. ruminis has previously been restricted t... |
### Question: Are gastrointestinal cell proliferation and crypt fission separate but complementary means of increasing tissue mass following infusion of epidermal growth factor in rats? ### Context: Epidermal growth factor (EGF) is a potent mitogen for the gastrointestinal tract and also influences the number of new cr... |
### Question: Is cD10 useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis? ### Context: Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to invest... |
### Question: Do high-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo? ### Context: To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX(3)CL1) and chemokine receptor (CCR2 and CX(3)CR1) expression, a mechanism for the atheroprotective prop... |
### Question: Does misexpression of the constitutive Rpgr ( ex1-19 ) variant lead to severe photoreceptor degeneration? ### Context: Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene are a frequent cause of X-linked retinitis pigmentosa. The RPGR transcript undergoes complex alternative splicing to exp... |
### Question: Is clinically localised prostate cancer microsatellite stable? ### Context: To determine the frequency of microsatellite instability (MSI) change with mono-, di- and tetranucleotide markers in clinically localized prostate cancer, and to correlate those markers with clinical and pathological variables.Two... |
### Question: Intraoperative defibrillation threshold testing during implantable cardioverter-defibrillator insertion: do we really need it? ### Context: The assessment of defibrillation efficacy using a safety margin of 10 J has long been the standard of care for insertion of implantable cardioverter-defibrillator (IC... |
### Question: Do mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla? ### Context: Reactive oxygen species (ROS) in the central nervous system are thought to contribute to sympathoexcitation in cardiovascular diseases such as hypertensio... |
### Question: Community-acquired pneumonia (CAP) hospitalizations and deaths: is there a role for quality improvement through inter-hospital comparisons? ### Context: To assess between-hospital variations in standardized in-hospital mortality ratios of community-acquired pneumonia (CAP), and identify possible leads for... |
### Question: Does inflamed pouch mucosa possess altered tight junctions indicating recurrence of inflammatory bowel disease? ### Context: The etiology of pouchitis after coloproctomucosectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis is still unknown. Beside changes in luminal antigens, the... |
### Question: Does genome-wide identification of transcriptional targets of RORA reveal direct regulation of multiple genes associated with autism spectrum disorder? ### Context: We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for aut... |
### Question: Do selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice? ### Context: Urinary tract obstruction during development leads to tubular atrophy and causes interstitial fibrosis. Macrophage infiltration into the interstitium plays a central role in this process. Selectins, a fam... |
### Question: Is lower serum calcium level associated with hemorrhagic transformation after thrombolysis? ### Context: We aim to investigate whether lower admission serum calcium levels are associated with hemorrhagic transformation (HT) after intravenous thrombolysis (IVT).A total of 362 patients treated with IVT was ... |
### Question: Long-term results of endobronchial brachytherapy: A curative treatment? ### Context: To evaluate outcomes after high-dose-rate endobronchial brachytherapy (HDR-EBBT) for limited lung carcinoma.A total of 106 patients with endobronchial lung cancer and not eligible for surgery or external beam radiotherapy... |
### Question: The evolution of floral nectaries in Disa (Orchidaceae: Disinae): recapitulation or diversifying innovation? ### Context: The Orchidaceae have a history of recurring convergent evolution in floral function as nectar production has evolved repeatedly from an ancestral nectarless state. However, orchids exh... |
### Question: Does keratinocyte growth factor pretreatment prevent radiation-induced intestinal damage in a mouse model? ### Context: Radiation-induced gastrointestinal syndrome is usually severe in clinical practice. Keratinocyte growth factor (KGF) plays an important role in the intestinal mucosal growth and repair o... |
### Question: Do we need to maximize the knowledge and attitude level of physicians and nurses toward organ donation and transplant? ### Context: We sought to assess the knowledge level, attitudes, and personal views of physicians and nurses toward organ donation and transplant.This is a cross-sectional survey, carried... |
### Question: Repeat Cardiovascular Risk Assessment after Four Years: Is There Improvement in Risk Prediction? ### Context: Framingham risk equations are widely used to predict cardiovascular disease based on health information from a single time point. Little is known regarding use of information from repeat risk asse... |
### Question: Does identification and early treatment of dehydration in home parenteral nutrition and home intravenous fluid patients prevent hospital admissions? ### Context: Early identification and treatment of dehydration is prudent in patients requiring home parenteral nutrition (HPN) or home intravenous fluids (H... |
### Question: Is aPOEε2 associated with milder clinical and pathological Alzheimer disease? ### Context: The Alzheimer disease (AD) APOEε4 risk allele associates with an earlier age at onset and increased amyloid-β deposition, whereas the protective APOEε2 allele delays the onset and appears to prevent amyloid-β deposi... |
### Question: Mesh repair for postoperative wound dehiscence in the presence of infection: is absorbable mesh safer than non-absorbable mesh? ### Context: In patients with postoperative wound dehiscence in the presence of infection, extensive visceral oedema often necessitates mechanical containment of bowel. Prostheti... |
### Question: Does autologous platelet-poor plasma decrease the bronchial stump necrosis in rat? ### Context: Necrosis of the bronchial stump is a very important trigger for bronchopleural fistula. The administration of local autologous platelet-poor plasma (PPP) could protect the bronchial stump.Left pneumonectomy was... |
### Question: Does semaphorin 5A promote gastric cancer invasion/metastasis via urokinase-type plasminogen activator/phosphoinositide 3-kinase/protein kinase B? ### Context: Semaphorin 5A, a member of the semaphorin family, was originally identified as an axonal guidance factor functioning during neuronal development. ... |
### Question: Does three-month exercise and weight loss program improve heart rate recovery in obese persons along with cardiopulmonary function? ### Context: Heart rate recovery (HRR) after exercise is an independent risk factor for cardiovascular disease and mortality, and it is well known to be modifiable by weight ... |
### Question: Does the cholecystokinin antagonist proglumide enhance the analgesic effect of dihydrocodeine? ### Context: To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.A double-blind, placebo-controlled crossover study of 30 a... |
### Question: Is connective tissue growth factor expression in endocrine tumors associated with high stromal expression of alpha-smooth muscle actin? ### Context: Complications due to fibrosis development are common in patients with well-differentiated endocrine carcinomas in the small intestine (ileal carcinoids). Con... |
### Question: Is hyperchloremia associated with mortality in critically ill patients? ### Context: The aim of the study was to determine if acid-base variables are associated with hospital mortality.This prospective cohort study took place in a university-affiliated hospital intensive care unit (ICU). One hundred seven... |
### Question: Clusters according to patient need in a long-stay inpatient population with schizophrenia: does executive dysfunction underpin needs-directed care? ### Context: To identify the external validators of patient clusters according to need in a long-stay inpatient population with schizophrenia.We recruited wit... |
### Question: Does obesity lead to declines in motor skills across childhood? ### Context: Poor motor skills have been consistently linked with a higher body weight in childhood, but the causal direction of this association is not fully understood. This study investigated the temporal ordering between children's motor ... |
### Question: Does phenotype-stratified genetic linkage study demonstrate that IBD2 is an extensive ulcerative colitis locus? ### Context: The complete elucidation of genetic variants that contribute to inflammatory bowel disease (IBD) will likely include variants that increase risk to both Crohn's disease and ulcerati... |
### Question: Does autophagy facilitate antibody-enhanced dengue virus infection in human pre-basophil/mast cells? ### Context: Dengue virus (DENV) infection can cause severe hemorrhagic disease in humans. Although the pathogenic mechanisms underlying severe DENV disease remain unclear, one of the possible contributing... |
### Question: Right ventricular ejection fraction during orthotopic liver transplantation: does anesthetic technique make a difference? ### Context: The objective of this study is to evaluate the right ventricular ejection fraction (RVEF) during orthotopic liver transplantation (OLT) under 2 different anesthetic regime... |
### Question: Is surgical intervention and accommodative responses , II : forward ciliary body accommodative movement facilitated by zonular attachments to the lens capsule? ### Context: To determine the role of the lens and the lens capsule in the three-dimensional architecture of the ciliary muscle at rest and during... |
### Question: Is birch pollen immunotherapy in mice : inhibition of Th2 inflammation sufficient to decrease airway hyper-reactivity? ### Context: Suppression of Th2 cytokine production by allergen-specific Th2 cells is considered to be critical for the suppression of allergic symptoms by subcutaneous immunotherapy. The... |
### Question: The impact of intraoperative neuromonitoring (IONM) on surgical strategy in bilateral thyroid diseases: is it worth the effort? ### Context: Intraoperative nerve monitoring (IONM) of the recurrent laryngeal nerve and the vagal nerve can detect nonfunctioning nerves (recurrent laryngeal nerve palsy, RLNP) ... |
### Question: A prospective trial of systematic nodal dissection for lung cancer by video-assisted thoracic surgery: can it be perfect? ### Context: There have been no reports evaluating the completeness of systematic nodal dissection with video-assisted thoracic surgery (VATS). In order to elucidate the completeness o... |
### Question: Do needle age and season influence photosynthetic temperature response and total annual carbon uptake in mature Picea mariana trees? ### Context: The carbon (C) balance of boreal terrestrial ecosystems is sensitive to increasing temperature, but the direction and thresholds of responses are uncertain. Ann... |
### Question: Does curcumin induce apoptosis in human neuroblastoma cells via inhibition of NFkappaB? ### Context: Metastasised neuroblastoma is a largely incurable neoplasia in children over one year of age using current treatment protocols. After dissemination to the bone, the survival rate is <7%, indicating an urge... |
### Question: Are outcomes Worse in US Patients Undergoing Surgery on Weekends Compared With Weekdays? ### Context: Increasing surgical access to previously underserved populations in the United States may require a major expansion of the use of operating rooms on weekends to take advantage of unused capacity. Although... |
### Question: Does a missense mutation ( S3660L ) in MLL3 gene influence risk of gastric cancer? ### Context: Several studies indicated that the expression level of MLL3 gene in gastric cancer tissue was associated with prognosis, and previous studies also suggested that genetic polymorphisms of MLL3 were related to th... |
### Question: Are higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques associated with a rupture-prone phenotype? ### Context: Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advance... |
### Question: Does 16S rDNA sequencing of valve tissue improve microbiological diagnosis in surgically treated patients with infective endocarditis? ### Context: The aim was to evaluate 16S rDNA sequencing in heart valves in patients with infective endocarditis undergoing surgery.Fifty-seven patients with infective end... |
### Question: Does dietary selenium augment sarcoplasmic calcium release and mechanical performance in mice? ### Context: As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in re... |
### Question: Are drug-free chitosan coated poly ( isobutylcyanoacrylate ) nanoparticles active against trichomonas vaginalis and non-toxic towards pig vaginal mucosa? ### Context: The present work reports a non-conventional therapeutic strategy based on the use of vaginally-applied formulations for the treatment of tr... |
### Question: Is minor neurological dysfunction in five year old very preterm children associated with lower processing speed? ### Context: Minor neurological dysfunction (MND) is present in one quarter to one third of children born very preterm (VP). The more severe form, complex (c)-MND has been associated with learn... |
### Question: Is catastrophic thinking about pain independently associated with pain severity , disability , and somatic complaints in school children and children with chronic pain? ### Context: To investigate the value of pain catastrophizing in explaining pain, disability, and somatic complaints, beyond negative aff... |
### Question: Does deletion of Prkcz increase intermittent ethanol consumption in mice? ### Context: Prkcz has been identified as a gene whose expression is positively correlated with ethanol (EtOH) consumption in mice and is also induced by EtOH. Two proteins are produced from Prkcz: protein kinase M zeta (PKMζ), whic... |
### Question: Is rheumatoid arthritis a risk factor for a high-riding vertebral artery? ### Context: A retrospective comparative study on the morphologic characteristics of the axis in patients with or without rheumatoid arthritis (RA).To compare the morphologic risk of vertebral artery (VA) injury during atlantoaxial ... |
### Question: Does pupil dilation influence subfoveal choroidal laser Doppler flowmetry? ### Context: The aim of this study was to assess (i) whether pupil dilation with tropicamide influences subfoveal choroidal blood flow, as assessed by continuous laser Doppler flowmetry (LDF) and (ii) if this is the case, whether t... |
### Question: Does profiling of Vascular Endothelial Growth Factor Receptor Heterogeneity identify Protein Expression-defined Subclasses of Human Non-small Cell Lung Carcinoma? ### Context: the vascular endothelial growth factor (VEGF) pathway plays a prominent role in the growth and progression of human cancer, includ... |
### Question: Do urinary & serum oxalate determination by oxalate oxidase immobilized on to affixed arylamine glass beads? ### Context: Although the measurement of oxalate in urine and serum by Amaranthus leaf oxalate oxidase immobilized on free arylamine glass beads is highly sensitive and specific, the handling of gl... |
### Question: Do newly induced beta-galactosidase molecules have a higher activity than the basally expressed enzyme? ### Context: The objective of this study was to compare the activities of individual molecules of induced and basally expressed Escherichia coli beta-galactosidase.Single-molecule assays of enzymes have... |
### Question: Is stathmin a highly sensitive and specific biomarker for vulvar high-grade squamous intraepithelial lesions? ### Context: Differentiating between human papilloma virus-dependent vulvar low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) remains difficult in selected cases. Stathmi... |
### Question: Does [ Pulchinenoside inhibit the fibroblast-like synoviocytes apoptosis in adjuvant arthritis rats ]? ### Context: To explore the eff ect of pulchinenoside (PULC) on fi broblast-like synoviocytes (FLS) apoptosis in adjuvant arthritis (AA) rats.A total of 60 SD rats were randomly divided into 8 groups: A ... |
### Question: Posterior tibial nerve stimulation: is the once-a-week protocol the best option? ### Context: Thirty-five patients (28 females, 7 males) with overactive bladder syndrome not responding to antimuscarinic therapy were enrolled in a prospective study. A total of 17 out of 35 patients were randomly assigned t... |
### Question: Does human recombinant apyrase therapy protect against canine pulmonary ischemia-reperfusion injury? ### Context: There is accumulating evidence that extracellular adenosine triphosphate (eATP) promotes many of the underlying mechanisms that exacerbate acute lung injury. However, much of these data are fr... |
### Question: Is off-pump technique a safer procedure for coronary revascularization? ### Context: We aim to describe our experience in coronary artery bypass grafting (CABG) with or without cardiopulmonary bypass by comparing intraoperative and postoperative outcomes.From January 1993 to June 2013, 3097 patients under... |
### Question: Is low subcutaneous thigh fat a risk factor for unfavourable glucose and lipid levels , independently of high abdominal fat . The Health ABC Study? ### Context: We investigated whether low subcutaneous thigh fat is an independent risk factor for unfavourable glucose and lipid levels, and whether these ass... |
### Question: Does long non-coding RNA CRNDE promote tumor growth in medulloblastoma? ### Context: Medulloblastoma is the most common malignant brain tumor in children. Despite remarkable advances over the past decades, a novel therapeutic strategy is urgently required to increase long-term survival. This study aimed t... |
### Question: Are sociodemographic , psychological , and lifestyle characteristics associated with a liking for salty and sweet tastes in French adults? ### Context: Various studies have shown that sensory liking influences dietary behavior and that individual characteristics are related to food intake and weight statu... |
### Question: Does tLR-3 receptor activation protect the very immature brain from ischemic injury? ### Context: We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. This robust LPS neuroprotection was not observed in P3 or P5 pups (correspondin... |
### Question: Does intervention study show outpatient cardiac rehabilitation to be economically at least as attractive as inpatient rehabilitation? ### Context: Since the late 1990 s, cost pressure has led to a growing interest in outpatient rehabilitation in Germany where predominantly inpatient rehabilitation has bee... |
### Question: The distribution of carotid endarterectomy procedures among surgeons and hospitals in New York state: is regionalization of specialized vascular care occurring? ### Context: In a published analysis of all carotid endarterectomies (CEAs) performed in New York state from 1990 to 1995, perioperative mortalit... |
### Question: Does chromosomal mosaicism mitigate stigmata and cardiovascular risk factors in Turner syndrome? ### Context: To study genotype-phenotype correlations in Turner syndrome (TS) regarding body composition, cardiovascular risk factors, stigmata and age at diagnosis vs. degree of mosaicism estimated as the per... |
### Question: Does being easily moved to tears as a response to psychological stress reflect response to treatment and the general prognosis in patients with rheumatoid arthritis? ### Context: Psychological stress affects the condition of patients with rheumatoid arthritis (RA). We evaluated the neuroendocrine and immu... |
### Question: Does hDAC5 promote cell proliferation in human hepatocellular carcinoma by up-regulating Six1 expression? ### Context: Histone deacetylases (HDACs) plays important roles in the regulation of genes expression and contribute to the growth of cancer cells. The present study aimed to investigate the function ... |
### Question: Are plasma matrix metalloproteinase-8 concentrations associated with the presence and severity of coronary artery disease? ### Context: Interstitial collagen, especially type I, is a major component of atherosclerotic plaques and the matrix metalloproteinases (MMP) 1, 8 and 13 can initiate collagen breakd... |
### Question: Does greater symptom duration predict response to immunomodulatory therapy in dilated cardiomyopathy? ### Context: Persistent inflammation contributes to cardiac dysfunction in chronic dilated cardiomyopathy (DCM). Trials of immunomodulatory therapy for DCM have been limited by small sample size and yield... |
### Question: Does pancreatitis-associated protein predict disease relapse in inflammatory bowel disease patients? ### Context: The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was ... |
### Question: Are NBME examination scores useful in selecting radiology residency candidates? ### Context: The quality of the graduates of radiology residency programs is powerfully affected by the quality of the candidates admitted to them, making the evaluation and ranking of residency applicants one of the most impo... |
### Question: Is alprazolam relatively more toxic than other benzodiazepines in overdose? ### Context: To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines.A database of consecutive poisoning admissions to a regional toxicology service was searched to identify con... |
### Question: Is peptidylarginine deiminase type 2 over expressed in the glaucomatous optic nerve? ### Context: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (P... |
### Question: Does a Multidisciplinary Evaluation help Identify the Antisynthetase Syndrome in Patients Presenting as Idiopathic Interstitial Pneumonia? ### Context: Interstitial lung disease (ILD) is 1 possible manifestation of the idiopathic inflammatory myopathies (IIM). Occasionally, patients presenting with ILD ar... |
### Question: Is smoking a strong risk factor for non-vertebral fractures in women with diabetes : the Tromsø Study? ### Context: In this longitudinal study of 4,160 postmenopausal women (3,947 without and 213 with self-reported diabetes), smoking was strongly related to fracture risk in those with diabetes.Smoking is ... |
### Question: Is soluble intercellular adhesion molecule-1 related to endothelial vasodilatory function in healthy individuals? ### Context: To investigate the associations between markers of systemic and vascular inflammation, and indicators of vascular morphology and function.In 59 apparently healthy individuals, we ... |
### Question: Does orally administered paracetamol act locally in the rat formalin test : evidence for a supraspinal , serotonin-dependent antinociceptive mechanism? ### Context: The mechanism of action of paracetamol (acetaminophen) remains elusive because it is still under discussion as to whether it acts locally and... |
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