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003/InvasionFront_CD3_block7_x2_y2_patient003_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6896.3,
+    "Centroid Y µm": 4722.5,
+    "Num Detections": 22507,
+    "Num Negative": 20222,
+    "Num Positive": 2285,
+    "Positive %": 10.15,
+    "Num Positive per mm^2": 905.4
+  }
+}

003/InvasionFront_CD8_block7_x1_y2_patient003_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6646.5,
+    "Centroid Y µm": 4947.4,
+    "Num Detections": 29474,
+    "Num Negative": 28044,
+    "Num Positive": 1430,
+    "Positive %": 4.852,
+    "Num Positive per mm^2": 586.75
+  }
+}

003/InvasionFront_CD8_block7_x2_y2_patient003_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 9170.1,
+    "Centroid Y µm": 5047.3,
+    "Num Detections": 17436,
+    "Num Negative": 16731,
+    "Num Positive": 705,
+    "Positive %": 4.043,
+    "Num Positive per mm^2": 336.23
+  }
+}

003/TumorCenter_CD3_block7_x1_y2_patient003_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4097.8,
+    "Centroid Y µm": 4997.4,
+    "Num Detections": 21529,
+    "Num Negative": 13127,
+    "Num Positive": 8402,
+    "Positive %": 39.03,
+    "Num Positive per mm^2": 3522.4
+  }
+}

003/TumorCenter_CD3_block7_x2_y2_patient003_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6546.5,
+    "Centroid Y µm": 5147.3,
+    "Num Detections": 27371,
+    "Num Negative": 16037,
+    "Num Positive": 11334,
+    "Positive %": 41.41,
+    "Num Positive per mm^2": 4039.6
+  }
+}

003/TumorCenter_CD8_block7_x1_y2_patient003_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3848.0,
+    "Centroid Y µm": 5197.2,
+    "Num Detections": 25603,
+    "Num Negative": 21746,
+    "Num Positive": 3857,
+    "Positive %": 15.06,
+    "Num Positive per mm^2": 1694.6
+  }
+}

003/TumorCenter_CD8_block7_x2_y2_patient003_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6271.7,
+    "Centroid Y µm": 5372.2,
+    "Num Detections": 36130,
+    "Num Negative": 32201,
+    "Num Positive": 3929,
+    "Positive %": 10.87,
+    "Num Positive per mm^2": 1418.2
+  }
+}

003/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2019,
+  "age_at_initial_diagnosis": 60,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 20,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

003/patient_pathological_data.json

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+{
+  "patient_id": "003",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "pN1",
+  "grading": "hpv_association_p16",
+  "hpv_association_p16": "positive",
+  "number_of_positive_lymph_nodes": 1.0,
+  "number_of_resected_lymph_nodes": 15,
+  "perinodal_invasion": "no",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Basaloid",
+  "infiltration_depth_in_mm": 7.0
+}

004/InvasionFront_CD3_block14_x5_y9_patient004_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16716.1,
+    "Centroid Y µm": 26585.9,
+    "Num Detections": 22291,
+    "Num Negative": 20419,
+    "Num Positive": 1872,
+    "Positive %": 8.398,
+    "Num Positive per mm^2": 771.88
+  }
+}

004/InvasionFront_CD3_block14_x6_y9_patient004_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19239.8,
+    "Centroid Y µm": 26735.8,
+    "Num Detections": 19950,
+    "Num Negative": 18059,
+    "Num Positive": 1891,
+    "Positive %": 9.479,
+    "Num Positive per mm^2": 819.91
+  }
+}

004/InvasionFront_CD8_block14_x5_y9_patient004_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16816.1,
+    "Centroid Y µm": 22113.3,
+    "Num Detections": 22421,
+    "Num Negative": 21337,
+    "Num Positive": 1084,
+    "Positive %": 4.835,
+    "Num Positive per mm^2": 459.42
+  }
+}

004/InvasionFront_CD8_block14_x6_y9_patient004_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19289.8,
+    "Centroid Y µm": 22188.3,
+    "Num Detections": 18537,
+    "Num Negative": 17390,
+    "Num Positive": 1147,
+    "Positive %": 6.188,
+    "Num Positive per mm^2": 504.71
+  }
+}

004/TumorCenter_CD3_block14_x5_y9_patient004_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16216.4,
+    "Centroid Y µm": 23137.7,
+    "Num Detections": 17677,
+    "Num Negative": 17178,
+    "Num Positive": 499,
+    "Positive %": 2.823,
+    "Num Positive per mm^2": 240.46
+  }
+}

004/TumorCenter_CD3_block14_x6_y9_patient004_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18715.1,
+    "Centroid Y µm": 23262.7,
+    "Num Detections": 19235,
+    "Num Negative": 18464,
+    "Num Positive": 771,
+    "Positive %": 4.008,
+    "Num Positive per mm^2": 348.73
+  }
+}

004/TumorCenter_CD8_block14_x5_y9_patient004_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15691.7,
+    "Centroid Y µm": 22987.8,
+    "Num Detections": 8108,
+    "Num Negative": 7995,
+    "Num Positive": 113,
+    "Positive %": 1.394,
+    "Num Positive per mm^2": 110.72
+  }
+}

004/TumorCenter_CD8_block14_x6_y9_patient004_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18215.4,
+    "Centroid Y µm": 23137.7,
+    "Num Detections": 13906,
+    "Num Negative": 13688,
+    "Num Positive": 218,
+    "Positive %": 1.568,
+    "Num Positive per mm^2": 128.99
+  }
+}

004/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2010,
+  "age_at_initial_diagnosis": 55,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 14,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "brachytherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

004/patient_pathological_data.json

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+{
+  "patient_id": "004",
+  "primary_tumor_site": "Oral_Cavity",
+  "pT_stage": "pT2",
+  "pN_stage": "pN0",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 13,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.3",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 8.0
+}

005/InvasionFront_CD3_block11_x1_y1_patient005_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3123.3,
+    "Centroid Y µm": 2623.6,
+    "Num Detections": 17093,
+    "Num Negative": 16081,
+    "Num Positive": 1012,
+    "Positive %": 5.921,
+    "Num Positive per mm^2": 473.0
+  }
+}

005/InvasionFront_CD3_block11_x2_y1_patient005_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5747.0,
+    "Centroid Y µm": 2573.6,
+    "Num Detections": 19623,
+    "Num Negative": 18450,
+    "Num Positive": 1173,
+    "Positive %": 5.978,
+    "Num Positive per mm^2": 531.39
+  }
+}

005/InvasionFront_CD8_block11_x1_y1_patient005_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6173.9,
+    "Centroid Y µm": 13046.8,
+    "Num Detections": 16207,
+    "Num Negative": 16048,
+    "Num Positive": 159,
+    "Positive %": 0.9811,
+    "Num Positive per mm^2": 79.46
+  }
+}

005/InvasionFront_CD8_block11_x2_y1_patient005_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 8950.6,
+    "Centroid Y µm": 12866.3,
+    "Num Detections": 19769,
+    "Num Negative": 19307,
+    "Num Positive": 462,
+    "Positive %": 2.337,
+    "Num Positive per mm^2": 208.64
+  }
+}

005/TumorCenter_CD3_block11_x1_y1_patient005_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7257.1,
+    "Centroid Y µm": 2597.5,
+    "Num Detections": 17408,
+    "Num Negative": 17015,
+    "Num Positive": 393,
+    "Positive %": 2.258,
+    "Num Positive per mm^2": 199.71
+  }
+}

005/TumorCenter_CD3_block11_x2_y1_patient005_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 9718.3,
+    "Centroid Y µm": 2339.8,
+    "Num Detections": 16708,
+    "Num Negative": 16548,
+    "Num Positive": 160,
+    "Positive %": 0.9576,
+    "Num Positive per mm^2": 78.33
+  }
+}

005/TumorCenter_CD8_block11_x1_y1_patient005_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5247.2,
+    "Centroid Y µm": 2148.9,
+    "Num Detections": 19662,
+    "Num Negative": 19537,
+    "Num Positive": 125,
+    "Positive %": 0.6357,
+    "Num Positive per mm^2": 56.47
+  }
+}

005/TumorCenter_CD8_block11_x2_y1_patient005_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7496.0,
+    "Centroid Y µm": 2373.7,
+    "Num Detections": 19228,
+    "Num Negative": 19110,
+    "Num Positive": 118,
+    "Positive %": 0.6137,
+    "Num Positive per mm^2": 54.68
+  }
+}

005/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2012,
+  "age_at_initial_diagnosis": 70,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "deceased",
+  "survival_status_with_cause": "deceased not tumor specific",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 39,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "no",
+  "adjuvant_radiotherapy_modality": null,
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

005/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "005",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "NX",
+  "grading": "hpv_association_p16",
+  "hpv_association_p16": "positive",
+  "number_of_positive_lymph_nodes": NaN,
+  "number_of_resected_lymph_nodes": 0,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 3.0
+}

006/InvasionFront_CD3_block6_x1_y10_patient006_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3897.9,
+    "Centroid Y µm": 25611.4,
+    "Num Detections": 20330,
+    "Num Negative": 17126,
+    "Num Positive": 3204,
+    "Positive %": 15.76,
+    "Num Positive per mm^2": 1263.1
+  }
+}

006/InvasionFront_CD3_block6_x2_y10_patient006_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6546.5,
+    "Centroid Y µm": 25711.4,
+    "Num Detections": 22963,
+    "Num Negative": 16932,
+    "Num Positive": 6031,
+    "Positive %": 26.26,
+    "Num Positive per mm^2": 2221.2
+  }
+}

006/InvasionFront_CD8_block6_x1_y8_patient006_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4347.7,
+    "Centroid Y µm": 19614.6,
+    "Num Detections": 24693,
+    "Num Negative": 24514,
+    "Num Positive": 179,
+    "Positive %": 0.7249,
+    "Num Positive per mm^2": 71.94
+  }
+}

006/InvasionFront_CD8_block6_x2_y8_patient006_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7096.2,
+    "Centroid Y µm": 19789.5,
+    "Num Detections": 23045,
+    "Num Negative": 22825,
+    "Num Positive": 220,
+    "Positive %": 0.9547,
+    "Num Positive per mm^2": 89.12
+  }
+}