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013/patient_pathological_data.json

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+{
+  "patient_id": "013",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT4a",
+  "pN_stage": "pN1a",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 1.0,
+  "number_of_resected_lymph_nodes": 58,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "yes",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.1",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 12.0
+}

014/InvasionFront_CD3_block3_x5_y8_patient014_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 17334.0,
+    "Centroid Y µm": 26444.3,
+    "Num Detections": 17216,
+    "Num Negative": 16262,
+    "Num Positive": 954,
+    "Positive %": 5.541,
+    "Num Positive per mm^2": 474.94
+  }
+}

014/InvasionFront_CD3_block3_x6_y8_patient014_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19852.9,
+    "Centroid Y µm": 26780.2,
+    "Num Detections": 17402,
+    "Num Negative": 16744,
+    "Num Positive": 658,
+    "Positive %": 3.781,
+    "Num Positive per mm^2": 312.72
+  }
+}

014/InvasionFront_CD8_block3_x5_y7_patient014_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 17535.8,
+    "Centroid Y µm": 17256.1,
+    "Num Detections": 15336,
+    "Num Negative": 13874,
+    "Num Positive": 1462,
+    "Positive %": 9.533,
+    "Num Positive per mm^2": 718.07
+  }
+}

014/InvasionFront_CD8_block3_x6_y7_patient014_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 20139.3,
+    "Centroid Y µm": 17290.8,
+    "Num Detections": 21733,
+    "Num Negative": 15467,
+    "Num Positive": 6266,
+    "Positive %": 28.83,
+    "Num Positive per mm^2": 2539.4
+  }
+}

014/TumorCenter_CD3_block3_x5_y7_patient014_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15890.8,
+    "Centroid Y µm": 24001.7,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

014/TumorCenter_CD3_block3_x6_y7_patient014_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18465.2,
+    "Centroid Y µm": 24087.2,
+    "Num Detections": 19285,
+    "Num Negative": 12722,
+    "Num Positive": 6563,
+    "Positive %": 34.03,
+    "Num Positive per mm^2": 2699.9
+  }
+}

014/TumorCenter_CD8_block3_x5_y7_patient014_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16741.1,
+    "Centroid Y µm": 19064.9,
+    "Num Detections": 18159,
+    "Num Negative": 14975,
+    "Num Positive": 3184,
+    "Positive %": 17.53,
+    "Num Positive per mm^2": 1480.4
+  }
+}

014/TumorCenter_CD8_block3_x6_y7_patient014_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19339.8,
+    "Centroid Y µm": 19239.8,
+    "Num Detections": 23082,
+    "Num Negative": 20466,
+    "Num Positive": 2616,
+    "Positive %": 11.33,
+    "Num Positive per mm^2": 1048.2
+  }
+}

014/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 55,
+  "sex": "female",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 33,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

014/patient_pathological_data.json

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+{
+  "patient_id": "014",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN2c",
+  "grading": "G3",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 8.0,
+  "number_of_resected_lymph_nodes": 44,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Basaloid",
+  "infiltration_depth_in_mm": 5.0
+}

015/InvasionFront_CD3_block11_x3_y1_patient015_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10594.4,
+    "Centroid Y µm": 2423.7,
+    "Num Detections": 20803,
+    "Num Negative": 20367,
+    "Num Positive": 436,
+    "Positive %": 2.096,
+    "Num Positive per mm^2": 180.34
+  }
+}

015/InvasionFront_CD3_block11_x4_y1_patient015_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12743.3,
+    "Centroid Y µm": 2623.6,
+    "Num Detections": 9368,
+    "Num Negative": 8965,
+    "Num Positive": 403,
+    "Positive %": 4.302,
+    "Num Positive per mm^2": 381.56
+  }
+}

015/InvasionFront_CD8_block11_x3_y1_patient015_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13921.3,
+    "Centroid Y µm": 12601.6,
+    "Num Detections": 20920,
+    "Num Negative": 20793,
+    "Num Positive": 127,
+    "Positive %": 0.6071,
+    "Num Positive per mm^2": 53.24
+  }
+}

015/InvasionFront_CD8_block11_x4_y1_patient015_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16594.6,
+    "Centroid Y µm": 12759.5,
+    "Num Detections": 8070,
+    "Num Negative": 7965,
+    "Num Positive": 105,
+    "Positive %": 1.301,
+    "Num Positive per mm^2": 123.45
+  }
+}

015/TumorCenter_CD3_block11_x3_y1_patient015_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14931.2,
+    "Centroid Y µm": 2394.5,
+    "Num Detections": 16325,
+    "Num Negative": 16007,
+    "Num Positive": 318,
+    "Positive %": 1.948,
+    "Num Positive per mm^2": 169.54
+  }
+}

015/TumorCenter_CD3_block11_x4_y1_patient015_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 17456.4,
+    "Centroid Y µm": 2570.9,
+    "Num Detections": 19541,
+    "Num Negative": 19213,
+    "Num Positive": 328,
+    "Positive %": 1.679,
+    "Num Positive per mm^2": 146.15
+  }
+}

015/TumorCenter_CD8_block11_x3_y1_patient015_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12268.5,
+    "Centroid Y µm": 2423.7,
+    "Num Detections": 17617,
+    "Num Negative": 17146,
+    "Num Positive": 471,
+    "Positive %": 2.674,
+    "Num Positive per mm^2": 234.01
+  }
+}

015/TumorCenter_CD8_block11_x4_y1_patient015_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14717.2,
+    "Centroid Y µm": 2473.7,
+    "Num Detections": 22780,
+    "Num Negative": 22143,
+    "Num Positive": 637,
+    "Positive %": 2.796,
+    "Num Positive per mm^2": 258.17
+  }
+}

015/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2012,
+  "age_at_initial_diagnosis": 54,
+  "sex": "male",
+  "smoking_status": "former",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 20,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "brachytherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

015/patient_pathological_data.json

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+{
+  "patient_id": "015",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "pN0",
+  "grading": "hpv_association_p16",
+  "hpv_association_p16": "positive",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 47,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 1.0
+}

016/InvasionFront_CD3_block11_x5_y7_patient016_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15366.9,
+    "Centroid Y µm": 16591.2,
+    "Num Detections": 16652,
+    "Num Negative": 15250,
+    "Num Positive": 1402,
+    "Positive %": 8.419,
+    "Num Positive per mm^2": 678.81
+  }
+}

016/InvasionFront_CD3_block11_x6_y7_patient016_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18165.4,
+    "Centroid Y µm": 16816.1,
+    "Num Detections": 19686,
+    "Num Negative": 18877,
+    "Num Positive": 809,
+    "Positive %": 4.11,
+    "Num Positive per mm^2": 352.4
+  }
+}

016/InvasionFront_CD8_block11_x5_y7_patient016_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18271.5,
+    "Centroid Y µm": 27816.1,
+    "Num Detections": 14514,
+    "Num Negative": 13527,
+    "Num Positive": 987,
+    "Positive %": 6.8,
+    "Num Positive per mm^2": 502.47
+  }
+}

016/InvasionFront_CD8_block11_x6_y7_patient016_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 21014.0,
+    "Centroid Y µm": 28218.2,
+    "Num Detections": 17445,
+    "Num Negative": 16791,
+    "Num Positive": 654,
+    "Positive %": 3.749,
+    "Num Positive per mm^2": 292.19
+  }
+}

016/TumorCenter_CD3_block11_x5_y7_patient016_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19026.4,
+    "Centroid Y µm": 17467.3,
+    "Num Detections": 18940,
+    "Num Negative": 16726,
+    "Num Positive": 2214,
+    "Positive %": 11.69,
+    "Num Positive per mm^2": 999.74
+  }
+}

016/TumorCenter_CD3_block11_x6_y7_patient016_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 21525.5,
+    "Centroid Y µm": 17669.7,
+    "Num Detections": 14942,
+    "Num Negative": 13730,
+    "Num Positive": 1212,
+    "Positive %": 8.111,
+    "Num Positive per mm^2": 629.92
+  }
+}

016/TumorCenter_CD8_block11_x5_y7_patient016_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16466.3,
+    "Centroid Y µm": 17290.8,
+    "Num Detections": 16992,
+    "Num Negative": 15461,
+    "Num Positive": 1531,
+    "Positive %": 9.01,
+    "Num Positive per mm^2": 700.01
+  }
+}

016/TumorCenter_CD8_block11_x6_y7_patient016_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19064.9,
+    "Centroid Y µm": 17365.8,
+    "Num Detections": 12586,
+    "Num Negative": 11939,
+    "Num Positive": 647,
+    "Positive %": 5.141,
+    "Num Positive per mm^2": 371.32
+  }
+}