Split (3)

train · 1k rows

id stringlengths 5 7	query stringlengths 4.64k 8.32k	answer stringlengths 392 2.53k
PLOS0	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The formation and progression of tumours to metastatic disease is driven by two major mechanisms, i.e. genetic alterations that activate oncogenes or inactivate tumour suppressor genes, and changes in the epigenome that cause variations in the expression of the genetic information. A deeper understanding of the interac...
PLOS1	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease remains a major public health problem in Latin America with over 13 million people infected. It is believed that the host immune response and genetic diversity of the parasite play an important role in the progression of Chagas disease, which presents a variety of clinical forms ranging from indeterminat...
PLOS2	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The work described here fills a current gap in the study of the 16 known DNA polymerases in vertebrate genomes. Until now, experiments with genetically disrupted mice have been reported for all but pol ν, encoded by the POLN gene. To intensively analyze the role of mammalian pol ν we generated multiple Poln-deficient m...
PLOS3	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Vaccines are considered a cost-effective way to control infectious diseases. To rationally design vaccines, antigens and, frequently, adjuvants must be selected to trigger appropriate immune responses against a specific pathogen. We selected dengue-2 envelope protein domain III as a dengue vaccine candidate and express...
PLOS4	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cells sense their surroundings and respond to soluble factors in the extracellular space. Extracellular factors frequently induce heterogeneous responses, thereby restricting the biological outcome to a fraction of the cell population. However, the question arises how such cell-to-cell variability can be controlled, be...
PLOS5	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The protozoan parasite Leishmania donovani is the cause of visceral leishmaniasis, a chronic disease that currently affects 12 million people worldwide. We are interested in understanding the immune mechanisms that can control infection. Preliminary studies suggested that CD8+ T cells can kill parasites and limit disea...
PLOS6	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Transmissible spongiform encephalopathies, which include the “mad cow” disease and the Creutzfeldt-Jakob disease, are related to the abnormal folding of a host protein termed the prion protein (PrP). Many aspects of the underlying molecular mechanism still remain elusive. Among the hypotheses that have been put forward...
PLOS7	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Trachoma causes visual impairment through the effect of in-turned eyelashes (trichiasis) on the surface of the eye. Epilation is a common traditional practice of intermittent plucking of lashes touching the eye, however, its long-term effectiveness in preventing visual impairment is unknown. We conducted a randomized c...
PLOS8	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue disease and its severe manifestations are a growing public health concern, with a third to half the world's population living in dengue-endemic areas. In recent years there have been significant advances in understanding dengue virus (DV) interactions with target cells such as macrophages, dendritic cells, hepat...
PLOS9	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In recent years, there has been growing interest in using computational models based on the human structural connectome to better understand the brain. These simulations typically investigate spontaneous neural dynamics, in the absence of tasks, sensory input or motor output. Here, we take a different approach, embodyi...
PLOS10	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Eukaryotic transcription occurs within the nucleus where DNA is packaged into high order chromosome structures. Some long-distance chromosomal interactions play an important role in gene regulation in higher eukaryotic species, such as mouse and human. In budding yeast, gene expression is traditionally thought to be re...
PLOS11	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In the germ line of sexually reproducing organisms, haploid gametes are generated from diploid precursor cells by a specialized cell division called meiosis. Reduction by half of chromosome numbers during the first meiotic division depends on genetic exchange, resulting in the formation of crossovers. Without crossover...
PLOS12	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Plants are continuously exposed to microorganisms. In order to resist infection, plants rely on their innate immune system to inhibit both pathogen entry and multiplication. We investigated the function of the Arabidopsis protein RIN4, which acts as a negative regulator of plant innate immunity. We biochemically identi...
PLOS13	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Larvicides are a key tool to prevent the growth of mosquito populations and decrease both the risks of outbreaks of mosquito-borne diseases and the nuisance deriving from bites. In order to assist municipalities from temperate areas in Europe in effectively planning vector control programs, we modelled the effect of la...
PLOS14	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Echolocating bats can fly through complex environments in complete darkness. Swift and apparently effortless obstacle avoidance is the most fundamental function supported by biosonar. Despite this, we still do not know which acoustic cues, from among the many possible cues, bats actually exploit while avoiding obstacle...
PLOS15	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Metabolism is the network of biochemical reactions that transforms available resources (“inputs”) into energy currency and building blocks (“outputs”). Different organisms have different assortments of metabolic pathways and input/output requirements, reflecting their adaptation to specific environments, and to specifi...
PLOS16	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	We introduce a novel statistical method to infer migration rates and population sizes across space in recent time periods. Our approach builds upon the previously developed EEMS method, which infers effective migration rates under a dense lattice. Similarly, we infer demographic parameters under a lattice and use a (Vo...
PLOS17	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	“Insulin resistance” is a chronic state of reduced sensitivity to the effects of circulating insulin. It is one of the hallmarks of metabolic disease and a consequence of ageing, but insulin resistance is also observed in otherwise healthy individuals after severe trauma/hemorrhage/sepsis, suggesting that it plays a ph...
PLOS18	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Sensory neurons sample their environment through highly branched structures termed dendritic arbors or trees. The precise patterning of dendritic arbors is important for the proper functioning of the nervous system, and evidence indicates an involvement of sensory neurons in neuropsychiatric disease such as autism spec...
PLOS19	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The cofactor NAD+ plays a central role in energy conservation pathways, shuttling electrons from the oxidation of growth substrates to respiratory or fermentative pathways. To sustain catabolism and cellular ATP demand, an appropriate balance between the reduced and oxidized forms of NAD+ must be maintained. Our genome...
PLOS20	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Previous studies have shown that Rb+/− mice develop pituitary adenomas; however, RB1 mutations have not been found in human pituitary tumors. In the present study, we uncovered a novel genetic pathway that may lead to Rb downregulation through RNA splicing mediated by usp39, a gene involved in assembly of the spliceoso...
PLOS21	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Intrauterine infection with human cytomegalovirus (HCMV) is a leading cause of developmental brain damage. In the U.S., an estimated 2,000 infants a year develop brain damage as a result of intrauterine infection with HCMV. In this study, we examined the contribution of host immune responses induced by CMV infection to...
PLOS22	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Diarrheal diseases are responsible for more than 1.5 million deaths annually in developing countries. Enterotoxigenic E. coli (ETEC) are among the most common bacterial causes of diarrhea, accounting for an estimated 300,000–500,000 deaths each year, mostly in young children. There unfortunately is not yet a vaccine th...
PLOS23	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Crimean-Congo hemorrhagic fever, an often fatal tick-borne viral disease, has made an impact in the Sultanate of Oman—affecting nationals and expatriates alike—for the past 20 years. In this retrospective review of the epidemiology and outcomes of cases in Oman from 1995 to 2017, we identified 4 sporadic cases in 1995 ...
PLOS24	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Normal cell functioning is dependent on balance between protein interactions and gene regulations. Although the balance is often perturbed by environmental changes, mutations, and noise in biochemical reactions, cellular systems can maintain their function despite these perturbations. This property of cells, called rob...
PLOS25	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	STAT6 is a transcriptional factor that plays an important role in the extracellular cytokine and virus-mediated immune response. Extensive studies have revealed that the dysregulation of STAT6 is linked to the pathological features of virus-associated cancers. However, the molecular mechanism of STAT6 regulation by tum...
PLOS26	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Similar to many other tropical regions of the world, dengue is a major public health problem in Bangladesh where Aedes aegypti mosquitoes are the main vector. Through this serological survey, we present data on the magnitude (measured in proportions) of seroprevalence and seroconversion within 12 selected wards in the ...
PLOS27	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Clostridium difficile, a major cause of antibiotic-associated diarrhea, produces resistant spores that facilitate its persistence in the environment including hospitals. C. difficile transmission is mediated by contamination of gut by spores. Understanding how this complex developmental process is regulated is fundamen...
PLOS28	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The human microbiome–the entire set of microbial organisms associated with the human host–interacts closely with host immune and metabolic functions and is crucial for human health. Significant advances in the characterization of the microbiome associated with healthy and diseased individuals have been obtained through...
PLOS29	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The clinical course of HIV-1 infection is characterized by considerable variability in the rate of progression to acquired immunodeficiency syndrome (AIDS) among patients with different genetic background. The human leukocyte antigen (HLA) B*5701 is the host factor most strongly associated with slow HIV-1 disease progr...
PLOS30	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human and animal trypanosomiases caused by Trypanosoma brucei parasites represent major burdens to human welfare and agricultural development in rural sub-Saharan Africa. Although the numbers of infected humans have decreased continuously during the last decades, emerging resistance and adverse side effects against com...
PLOS31	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The current model on G protein–coupled receptors (GPCRs) is that they have at least one endogenous ligand for the activation of the heterotrimeric G proteins that controls lots of physiological functions. Currently, 140 out of approximately 800 GPCRs are referred to as orphan because of a lack of knowledge about their ...
PLOS32	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Machine learning-based approaches hold great promise to pave the way for high-throughput animal sleep monitoring. With the novel developments of gene-engineering techniques and the proliferation of experimental sleep studies, the need for the automation and cross-lab standardization of sleep scoring becomes more immine...
PLOS33	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Toxoplasma gondii is an obligate intracellular parasite and is not able to replicate outside the host cell. The parasite lives in a specialized parasitophorous vacuole in contact with the host cytoplasm through the parasitophorous vacuole membrane. It is highly likely that a very active exchange of metabolites occurs b...
PLOS34	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Understanding the evolutionary and genomic changes involved in the emergence of new pathogens and shifts in virulence spectra is vital for deciphering the biological process of disease emergence and for designing new and effective disease control methods. In this study, we employed comparative genomics in order to exam...
PLOS35	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Infections of humans with the protozoan parasites L. donvani and L. infantum can lead to the development of the disease visceral leishmaniasis, but also to an asymptomatic status. However, the mechanisms that result in these clinical outcomes after infection are poorly understood. In this study, we applied a data-drive...
PLOS36	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Despite the appearance of cooperation in nature, selection should often favor exploitative individuals who perform less of any cooperative behaviors while maintaining the benefits accrued from the cooperative behavior of others. This conflict of interest among cooperating individuals can lead to the evolution of comple...
PLOS37	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Proteins destined for secretion from the cell, including soluble secreted and membrane proteins (SMPs), are translocated into the endoplasmic reticulum (ER) either directly upon translation on the ER surface or post-translationally, as in the case of type II membrane proteins. Interestingly, several studies have demons...
PLOS38	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Infectious diseases transmitted by Aedes aegypti, also known as the yellow fever mosquito, are of growing concern in tropical and subtropical regions. Dengue and Zika incidences are increasing, and no vaccines are currently available. Here we investigate the origin of California A. aegypti and find that this mosquito l...
PLOS39	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Biofuels research is focused on understanding the energy-related metabolic capabilities of a broad range of biological species. To this end we sequenced the genome of Rhodococcus opacus PD630, a bacterium that accumulates close to 80% of its cellular dry weight in oil, a rare trait in the prokaryotic and eukaryotic kin...
PLOS40	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	There are potentially many factors responsible for how archaeal and bacterial genomes are composed. Recent advances in DNA sequencing have made it possible to use computational and statistical methods to examine the interplay between evolution and genomic composition. We wished to see whether particular properties coul...
PLOS41	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Insertion of foreign DNA into mammalian genomes, and the deletion of DNA, may have unintended consequences extending beyond the site of the mutation. In the mouse, the insertion of foreign DNA, including foreign regulatory DNA, combined with the deletion of part of the targeted gene, had striking effects on the regulat...
PLOS42	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The development of the gonads in vertebrates is mainly regulated by dmrt1, a master sex-determining gene that has a timely and spatially controlled gonadal expression pattern. In addition to transcriptional regulation, a sequence motif located in the 3′ UTR (D3U-box) mediates transcript stability of dmrt1 mRNAs. Howeve...
PLOS43	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Mosquitoes transmit various causative agents of diseases and the blockage of vector life cycle is an effective way to hamper disease transmission. The egg is the least known life stage and understanding it can contribute with novel strategies for mosquito control. Mosquitoes lay eggs in water collections, some of which...
PLOS44	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	To test the hypothesis that infection with helmiths may increase host susceptibility to infection with HIV-1, we quantified the amount of a clade C simian-human immunodeficiency virus needed to infect rhesus macaques that had acute Schistosoma mansoni infections. Compared to control animals exposed to virus alone, monk...
PLOS45	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The segmentation clock has been widely considered vital for somite formation, because clock-deficient embryos display severe segmental defects. However, irregular somites are still formed, suggesting that the clock is not required for somite formation itself but rather endows it with developmental reproducibility. Thus...
PLOS46	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Protein function requires a three-dimensional structure with specific dynamic features for catalytic and binding events, and, in many cases, the structure results from the assembly of more than one polypeptide chain (also called monomer or subunit) to form an oligomer or multimer. Proteins such as hemoglobin or chapero...
PLOS47	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	At least 15 million doses of anti-rabies post-exposure prophylaxis are administered annually worldwide, and an estimated 55,000 people die of rabies every year. Over 99% of these deaths occur in developing countries, predominantly in Asia and in Africa where rabies is endemic in domestic dogs. Despite the global health...
PLOS48	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	This year the 2014 FIFA World Cup will be hosted by Brazil, a country that has reported a higher number of dengue cases annually than any other country worldwide over the last decade. About 600,000 foreign tourists are expected and may be at risk for this disease. Games will be played in 12 different cities across the ...
PLOS49	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Obesity and its related metabolic diseases are growing problems worldwide. Brown adipose tissue (BAT) with its capability of burning off fat to generate heat is now at the center of research interest as target of therapeutic intervention for obesity treatment. In order to get a better understanding of the molecular mec...
PLOS50	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Paracoccidioidomycosis (PCM) is a neglected systemic fungal infection prevalent mostly in South America. Serological tests have long been established as rapid, simple and inexpensive tools for the diagnosis and follow-up of PCM. However, different protocols and reagents are used. We compared here the performance of six...
PLOS51	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Hookworm-related cutaneous larva migrans (CLM) is a parasitic skin disease common in developing countries with hot climates. In resource-poor settings, CLM is associated with considerable morbidity. The disease is caused by animal hookworm larvae that penetrate the skin and migrate aimlessly in the epidermis as they ca...
PLOS52	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	American Visceral leishmaniasis (VL) is an anthropozoonosis resulting from infection by Leishmania infantum mainly transmitted by the bite of females of the sand fly Lutzomyia longipalpis which feed mainly on domestic dogs. It is a serious tropical disease that in some countries has spread in association with several f...
PLOS53	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The intestine harbors a dense community of commensal bacteria that play a vital role in host health and homeostasis, but it is also the port of entry for many pathogens. An important function of the intestinal epithelial cells is coordinating the immune response to microbial signals, ranging from tolerance towards bene...
PLOS54	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	RNA is an outstanding target for oncological intervention. Engineering the most common RNA binding motif in human proteins (called RRM) so as to bind to a specific RNA has an enormous pharmacological potential. Yet, it is highly non trivial to design RRM-bearing protein variants with RNA selectivity and affinity suffic...
PLOS55	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schistosomiasis (bilharziasis) is a global parasitic infection with more than 240 million people infected. It is caused by Schistosoma flatworms that live in the bloodstream. Current treatment relies on one drug, and no effective vaccine has yet been developed. Proteolytic enzymes (proteases) help the parasite survive ...
PLOS56	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	γδ T cells are unconventional T lymphocytes that play a unique role in host protection against pathogens. Human Cytomegalovirus (HCMV) is a widespread virus that can cause severe organ disease such as hepatitis and pneumonitis in immune-compromised patients. Our decade-long study conveys compelling evidence for the imp...
PLOS57	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Coordinated protease activity is essential to parasite survival. Throughout its life cycle, the Plasmodium parasite expresses a potent cysteine protease inhibitor that has the potential to inhibit parasite as well as host cell cysteine proteases. We have generated a stage-specific knockout of this inhibitor and were ab...
PLOS58	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Elucidating how regulation of chromatin structure modulates gene expression patterns is fundamental for understanding mammalian development. Replacement of core histones with histone variants has recently emerged as a key mechanism for regulating chromatin states. The histone H2A variant H2A.Z is of particular interest...
PLOS59	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The study of stem cell and tissue dynamics in vivo is often carried out by lineage tracing methods that depend on the presence of specific markers and on the availability of stem cells. In the current study, we applied a novel method for the reconstruction of cell lineage trees from microsatellite mutations accumulated...
PLOS60	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Antiretroviral therapy (ART) improves the quality of life for HIV infected individuals. However, ART is currently a lifelong commitment because HIV persists during treatment despite being suppressed below detection. If therapy is stopped, the HIV reappears. A concerted effort is ongoing to develop new eradication thera...
PLOS61	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue is a viral infection of humans that is transmitted by mosquitoes. Dengue is a very important public health problem in many developing countries. Recently, new tests to help diagnose patients with dengue have been developed. Evaluating these tests to see how well they perform in different countries and in differe...
PLOS62	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Rabies is a devastating yet preventable disease that causes around 59,000 human deaths annually of which a large proportion occurs in Sub Saharan Africa (SSA). In order to eliminate rabies, annual vaccination of at least 70% of the dog population is recommended. In SSA most rabies vaccination programmes use static poin...
PLOS63	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Tsetse flies transmit the causative agents of African sleeping sickness and nagana in sub-Saharan Africa. The parasites are acquired when tsetse flies feed on an infected host, undergo multiplication in the fly gut and migrate to the salivary glands (SG). The cycle resumes once this infected fly transmits the parasites...
PLOS64	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Visceral leishmaniasis, caused by Leishmania infantum and L. donovani, is characterized by high rate mortality worldwide. Current treatments for this disease suffer from toxicity, variable efficacy, requirements for parenteral administration and length of treatment regimens. New chemical entities and development of new...
PLOS65	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Trypanosomes are single-celled organisms transmitted by the biting tsetse fly, which cause sleeping sickness in humans in sub-Saharan Africa, but also infect livestock and other mammals. Most trypanosomes cannot infect humans as they die in human serum, but two mutants of Trypanosoma brucei have evolved the ability to ...
PLOS66	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Our brain's ability to perform cognitive processes, such as object identification, problem solving, and decision making, comes from the specific connections between neurons. The neurons carry information as spikes that are transmitted to other neurons via connections with different strengths and propagation delays. Exp...
PLOS67	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Zoonotic visceral leishmaniasis (ZVL) is a potentially deadly disease in humans caused by Leishmania infantum. This leishmania species can be delivered by pool blood feeding zoo-anthropophilic phlebotomine flies to several mammals, the dog population being recognized as the main reservoir. Transmission from infected do...
PLOS68	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Malaria remains a major public health problem in many parts of the tropical world. All the clinical symptoms of malaria are attributed to the blood stage of the parasite life cycle during which Plasmodium merozoites invade and multiply within host erythrocytes. Invasion by Plasmodium merozoites is a complex process tha...
PLOS69	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Tumor vessels being very different from their normal counterparts are leaky and lack organization that sustains blood circulation. As a result, insufficient blood supply and high fluid pressure begin to appear inside the tumor which leads to a reduced delivery of drugs within the tumor, especially in tumor center. A tr...
PLOS70	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dendritic cells (DCs) are one of the initial cellular targets of HIV-1 and can play a crucial role in determining the course of virus infection in vivo. While sentinel functions of DCs are essential for establishment of an antiviral state, HIV-1 can subvert DC function for its dissemination. One of the mechanisms by wh...
PLOS71	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The formation of bone around a cartilage template is the predominant ossification process in humans, and it has many complex steps that must be coordinated properly in space and time. Cartilage-producing cells (chondrocytes) first secrete a cartilage matrix around themselves that is rich in sugar-coated proteins called...
PLOS72	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever, caused by a tick-borne phlebovirus. Studies have found that a variety of domestic and wildlife animals can be infected by SFTS virus (SFTSV), but the natural reservoir host for the virus remains unclear. Although the SFTSV-RNA was iden...
PLOS73	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Almost all of our current understanding of the molecular mechanisms that govern host-pathogen interactions in the ocean is derived from experiments carried out at the population level, neglecting any heterogeneity. Here we used a single cell approach to unmask the phenotypic heterogeneity produced within infected popul...
PLOS74	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Proteins that cooperate to perform a specific cellular function often interact with each other and are clustered together in a protein-protein interaction network (PIN). Thus, a protein’s function can be inferred from the prevailing functions of its network neighbors. However, the network neighborhood is highly dynamic...
PLOS75	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Many features of pathogen diversification remain poorly explored although host immunity is recognized as a major driver of pathogen evolution. Influenza A viruses (IAVs) can infect many avian and mammalian hosts, but while few IAV subtypes circulate in human populations, subtype diversity is extensive in wild bird popu...
PLOS76	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Bacteria evolve rapidly due to their short generation time and their ability to exchange genetic material, which can occur via different processes, collectively named Horizontal Gene Transfer (HGT). Most bacteria contain, besides a single chromosome, autonomously replicating units called plasmids. Many plasmids carry g...
PLOS77	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue virus is primarily transmitted by Aedes aegypti mosquitoes. Control of the vector mosquito is the major practice to prevent dengue. However, it is not well known how the virus can infect some mosquito strains but fail to do so with other refractory strains. To address that question, we conducted whole genome mic...
PLOS78	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Loa loa (the parasite causing loiasis), also known as African eye worm, is endemic in forest areas of west and central Africa. In several of the endemic areas, it co-exists with onchocerciasis and lymphatic filariasis (LF). Because of the benefit individuals suffering from onchocerciasis could have by taking ivermectin...
PLOS79	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	An important feature of genome organization is that transcription and replication are selectively co-oriented. This feature helps to avoid conflicts between head-on replication and transcription. The precise consequences of the conflict and how it affects genome organization remain to be understood. We previously found...
PLOS80	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schistosomiasis is a major neglected tropical disease (NTD), which afflicts > 200 million people in developing countries. The genome sequence of the schistosome parasite has been decoded; it includes > 10,000 genes. New approaches to control this NTD are sought and genomic information may provide targets for new treatm...
PLOS81	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Leptospirosis, caused by pathogenic Leptospira spp., constitutes an increasing global public health threat. Humans are accidental hosts, and acquire the disease primarily from contact with water sources that have been contaminated with urine from infected animals. Rats are asymptomatic carriers of infection and are cri...
PLOS82	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Many natural pathogens elicit large antigen-specific long-lived effector memory CD8 T cell responses that contribute to pathogen protection and control. This strategy is also employed by novel CD8 T cell vaccine vectors. In the real world, the host is likely to encounter a number of such pathogens at different times bu...
PLOS83	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Sexual dimorphisms such as the exaggerated antlers of deer, the enormous clawed chelae of crabs, and the horns and mandibles of beetles, are widespread across animal taxa and have fascinated biologists for centuries. Much recent work has uncovered the importance of the role of the sex-determination pathway in the expre...
PLOS84	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Mitochondrial dysfunction and reduced insulin secretion are key features of β-cell dysfunction in Type 2 diabetes (T2D). Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21 that also displays β-cell mitochondrial dysfunction and reduced insulin secretion in humans. Given these similarities in β-...
PLOS85	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Rabies is one of the oldest known zoonoses, caused by lyssaviruses. In recent years, more than 21,000 nucleotide sequences for rabies viruses (RABV) have been deposited in public databases. In this study, a novel mathematical approach called affinity propagation (AP) clustering, a highly powerful tool, to verifiably di...
PLOS86	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In recent years it has become clear that complex developmental processes are not regulated by single transcription factors but rather by combinations of transcription factors that interact in intricate regulatory networks. Here, we analyze the regulatory network that drives terminal differentiation of oligodendrocytes,...
PLOS87	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dendritic tree structures of nerve cells are built to optimally collect inputs from other cells in the circuit. By looking at how regularly the branch and termination points of dendrites are distributed, we find characteristic differences between cell types that correlate little with other traditional branching statist...
PLOS88	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Zinc deficiency affects one-third of the world’s population and is associated with an increased susceptibility to bacterial infection. Despite this, the molecular basis for how zinc deficiency compromises host control of infection remains to be understood. We show that dietary zinc deficiency impacts host tissue zinc a...
PLOS89	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Gene transcription is regulated by the coordinated interaction of genetic, epigenetic and trans-acting factors. The chromatin environment at gene promoters, including positioned nucleosomes that may display functional histone modifications, is a key regulator of gene expression, contributing to transcriptional activati...
PLOS90	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue manifestations may vary from asymptomatic to potentially fatal complications. With an increasing number of Dengue Hemorrhagic fever (DHF) and fatal cases, the availability of new approaches useful for cases confirmation plays an important role for the d...
PLOS91	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	HIV testing remains low among key populations, including MSM, especially in low- and middle-income countries. Although crowdsourcing has been recommended as a tool for developing public health interventions, few studies have formally evaluated crowdsourcing as a way to promote health in a real-world setting. Previous s...
PLOS92	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In order to evade detection and destruction by cytotoxic lymphocytes and successfully persist within their hosts, cytomegalovirus (CMVs) have evolved a number of genes dedicated to block immune recognition. Certain CMVs and other large DNA viruses encode homologs of the cell-surface molecule CD48, a ligand of the 2B4 r...
PLOS93	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The myelin membrane is a highly specialized plasma membrane that enwraps axons, acts as an insulator, and is thus important for fast conduction of action potentials. It is thereby critical for proper functioning of the nervous system. Myelin in the central nervous system is synthesized by oligodendrocytes. Because myel...
PLOS94	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Proteins are large molecules that living cells make by stringing together building blocks called amino acids or peptides, following their blue-prints in the DNA. Freshly made proteins are typically long, structure-less chains of peptides, but shortly afterwards most of them fold into characteristic structures. Proteins...
PLOS95	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Hantaan virus (HTNV), the prototype of the Hantavirus genus, is a rodent-borne pathogen that causes human hemorrhagic fever with renal syndrome (HFRS) with a mortality rate of approximately 15% in Asia. Since effective prevention is not available currently and the non-specific symptoms at the early stage of the disease...
PLOS96	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	This work was conducted in coastal Guinea, the last focus in Western Africa where the transmission of Human African Trypanosomiasis (HAT) is still very active. The Guinean government and his partners are conducting HAT control activities to reduce the burden of this neglected tropical disease and, as set-up by WHO, to ...
PLOS97	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schizophrenia is a complex mental disease, which includes symptoms of delusions, hallucinations, disorganized speech, aberrant behavior, lack of emotional expression, diminished motivation, and social withdrawal. The cause of schizophrenia is unknown, but there is extensive evidence that genetics play a significant rol...
PLOS98	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The normally commensal yeast, Candida albicans is the leading cause of both oral and vaginal thrush, as well as life-threatening disseminated infections in the nosocomial setting. Treatment of such infections is hampered by the limited number of suitable antimycotics. Therefore, understanding how this fungus causes dis...
PLOS99	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Generation of antibody-producing cells through terminal B cell differentiation represents a good model to study the formation of multiple effector cells from a progenitor cell type. This process is controlled by the action of several molecules that maintain cell type specific programs in response to cytokines, antigen ...

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