Datasets:

cglez
/

ohsumed

Unnamed: 0 int64 0 10.4k	id int64 0 10k	text stringlengths 166 4.02k	label stringclasses 23 values
0	7,866	Continuous, in vivo pulmonary venous admixture from fiberoptically measured hemoglobin saturations. In six anesthetized swine, pulmonary venous admixture (Qsp/Qt) was calculated by four methods: a) Qsp/Qt 1, fiberoptically measured arterial and mixed venous Hgb saturation (SaO2 and SvO2), PaO2 and PvO2 derived from sa...	C22
1	4,656	Pichinde virus infection in strain 13 guniea pigs reduces intestinal protein reflection coefficient with compensation. Pichinde virus inoculation into strain 13 guinea pigs is a model with features reputed to be similar to hemorrhagic fever in humans. Although the infection is lethal by day 13-19, guinea pigs of appr...	C22
2	3,932	Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate. The trace element vanadium exerts insulinlike effects in vitro and decreases hyperglycemia in insulin-deficient animals. This study examined whether vanadate can improve glucose homeostasis in genetically obese hyperglycemic insulin...	C22
3	5,446	Ischemic brain damage in a model of acute subdural hematoma. Ischemic brain damage is the most important neuropathological finding in humans who die after acute subdural hematoma; however, its causes are poorly understood. We have produced acute subdural hematoma in the rat by injecting 400 microliters of autologous ...	C22
4	536	Effect of cyclosporin on generalized Shwartzman reaction in diabetic rats. The effect of cyclosporin (CsA) on the endotoxin-induced generalized Shwartzman reaction (GSR) was studied in diabetic and nondiabetic rats. After 4.5 wk of diabetes, CsA (20 mg/kg) or intralipid as a control substance was given intraperitonea...	C22
5	7,218	L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat. Tryptophan-associated eosinophilia-myalgia syndrome (L-TRP-EMS) is a newly described syndrome which occurred in epidemic fashion in the United States in the summer and fall of 1989. Epidemiologic data ha...	C22
6	9,013	Receptor changes in the spinal cord of sheep associated with exposure to chronic pain. There is evidence that post-injury hypersensitivity is partly due to changes in the central nervous system. Sheep with foot rot were used to investigate the effect of chronic pain on some receptors thought to be involved in spinal ...	C22
7	2,881	SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits. To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late ...	C22
8	589	In vivo assessment of shock-wave pressures. Implication for biliary lithotripsy. During extracorporeal shock-wave lithotripsy, the pressure profile, which is generated by the lithotriptor, determines the risk of tissue damage. In the present study, the pressure distribution of a lithotriptor (Lithostar; Siemens A.G.,...	C22
9	3,148	Calcium, parathyroid hormone, and vitamin D in the "prehypertensive" Dahl salt-sensitive rat. The purpose of this study was to determine if alterations of calcium and calcium regulating hormones precede the onset of NaCl-induced hypertension in the Dahl salt-sensitive (S) rat. After a 5-day balance study, serum ioniz...	C22
10	3,898	Experimental models of temporal lobe epilepsy: new insights from the study of kindling and synaptic reorganization. Temporal lobe epilepsy is a common localization-related epileptic syndrome characterized by complex partial seizures, ictal and interictal epileptic discharges arising from limbic structures of the tempo...	C22
11	6,283	Chronic ethanol feeding and acute ethanol exposure in vitro: effect on intestinal transport of biotin. This study examined the effects of chronic ethanol feeding and acute ethanol exposure in vitro on biotin transport in rat intestine. Transport studies were performed with intestinal everted sacs. Ethanol was fed to...	C22
12	4,682	Treatment evaluation of experimental staphylococcal infections: comparison of beta-lactam, lipopeptide, and glycopeptide antimicrobial therapy. LY 146032, teicoplanin, vancomycin, oxacillin, cephalothin, cefamandole, ampicillin plus sulbactam, and cefoperazone plus sulbactam were studied against six isolates of staphy...	C22
13	5,970	Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin. Elevated free Ca2+ concentrations found in adult dystrophic muscle fibers result in enhanced protein degradation. Since the difference in concentrations may reflect differences in entry, Ca2+ leak channels in cultures of n...	C22
14	8,536	Effects of exercise on myocardial catecholamine content and ischemic injury in dogs with gradual coronary occlusion. The effects of exercise on catecholamine content and the extent of myocardial damage in dogs with Ameroid constrictor occlusion of the left circumflex coronary artery were determined. Tissue samples fr...	C22
15	2,592	Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. The authors describe the histopathologic evolution of Lyme disease in severe combined immunodeficiency (scid) and normal C.B-17 and C57BL/6 mice inoculated with Borrelia burgdorferi. Starting...	C22
16	7,695	Venous hemodynamics in a chronic venous valvular insufficiency model. To develop a large-animal model of chronic venous valve incompetence, 13 greyhound dogs underwent unilateral hindlimb venous valve lysis with a valve cutter apparatus pulled retrograde through the iliac, femoral, and lateral saphenous veins. Bilate...	C22
17	5,637	Case-control study of Cryptosporidium parvum infection in Peruvian children hospitalized for diarrhea: possible association with malnutrition and nosocomial infection. A retrospective, hospital-based case-control study was used to investigate whether there were any clinical characteristics that could distinguish Crypt...	C22
18	2,598	Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung. Lung injury induced by intratracheal instillation of cadmium chloride (CdCl2) into the rat lung may serve as a model of human interstitial lung disease. In this study, CdCl2 solutions were instilled through a lobar bronchus i...	C22
19	8,473	Evaluation of metastatic cardiac calcification in a model of chronic primary hyperparathyroidism. Recent reports have fueled an interest in the prevalence and significance of metastatic calcium deposition in patients with chronic hyperparathyroidism. Experimental data are limited by the lack of suitable in vivo anima...	C22
20	7,824	Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent. The aseptically loosened prosthesis provided a means for investigating the in vivo and in vitro activity of the cells associated with the loosening process in seven dogs. The cells were isolated and maintai...	C22
21	7,976	Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy. We compared the effects of the angiotensin-converting enzyme inhibitor enalapril and a conventional antihypertensive regimen (hydralazine and metoprolol) on kidney function, albuminuria,...	C22
22	6,476	Development of multiple necrotizing enteritis induced by a tumor necrosis factor-like cytokine from lipopolysaccharide-stimulated peritoneal macrophages in rats. We report the development of an animal model of multiple necrotizing enteritis (MNE) in rats. When rats were injected directly with a culture supernatant of...	C22
23	7,385	Scatter photocoagulation restores tissue hypoxia in experimental vasoproliferative microangiopathy in miniature pigs. Experimental retinal branch vein occlusion using argon laser photocoagulation in miniature pigs induced the development of ischemic retinal territories associated with preretinal neovascularization. P...	C22
24	372	Kinin/prostaglandin system: its therapeutic value in surgical stress. Multiple system organ failure as a consequence of injury or sepsis remains the major reason for death in critically ill patients. One of the treatment concepts that has recently attracted clinical attention is the administration of kinins and prost...	C22
25	8,202	Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep. The potential of GST as a vaccine candidate against liver fluke infection in ruminants was studied by vaccinating sheep (n = 9) with GST purified from adult worms of Fasciola hepatica and challenging with 500 F. hepatica metacercar...	C22
26	7,528	Regional ischemia in cerebral venous hypertension due to embolic occlusion of the superior sagittal sinus in the rat. To determine the pathophysiological changes in brain tissue that characterize damage following cerebral venous hypertension, a model of cerebral venous hypertension in the rat was devised. This experi...	C22
27	2,639	Isolation of Tete serogroup bunyaviruses from Ceratopogonidae collected in Colorado. Two viruses were isolated from ceratopogonid midges collected in northern Colorado. Electron microscopy indicated that both isolates were bunyavirus-like. Indirect fluorescent antibody and serum dilution-plaque reduction neutralizat...	C22
28	2,128	Effect of diltiazem and thromboxane A2 synthetase inhibitor (OKY-046) on vessels following experimental subarachnoid hemorrhage. In order to examine the functional changes in the vascular smooth muscle, the effects of a thromboxane A2 synthetase inhibitor (OKY-046) and a calcium channel blocker (diltiazem) on vessels ...	C22
29	8,283	Laparoscopic tubal sterilization. The potential for thermal bowel injury. One of the most severe complications of laparoscopic tubal sterilization is bowel burns, although they often go undetected at the time of laparoscopy. Controversy remains over whether these injuries are caused directly by operator error or indi...	C22
30	6,660	Hemodynamic determinants of subdiaphragmatic venous return during closed-chest CPR in a canine cardiac arrest model. OBJECTIVE: To assess the hemodynamic determinates of peripheral subdiaphragmatic venous-to-right-heart return during closed-chest CPR. MODEL: Seven anesthetized dogs subjected to electrically induced v...	C22
31	9,983	The effect of chronic renal insufficiency on cyclosporine nephrotoxicity. Despite cyclosporine's efficacy in preventing rejection, its use has been hampered by nephrotoxicity. Questions remain concerning its application in patients with decreased renal function. The purpose of this study was to 1) establish a reliab...	C22
32	5,464	Spinal cord thromboplastin-induced coagulopathy in a rabbit model. Coagulopathy results from many diverse events, including several neurogenic causes. Using a rabbit model, we produced coagulopathy by injecting autologous spinal cord and extracted thromboplastin intravenously. Serial coagulation panels were performe...	C22
33	571	Prevention of necrotizing enterocolitis in the rat with prenatal cortisone. Cortisone acetate is known to accelerate maturation of the immature intestine. The effect of prenatal administration of cortisone acetate on the morbidity and mortality of necrotizing enterocolitis was examined in a rat pup model. Pregnant r...	C22
34	7,267	The HIV cytopathic effect: potential target for therapy? HIV kills activated infected CD4+ T cells after a burst of replication and the release of large numbers of virions. From a review of the literature on HIV regulatory genes and from preliminary mathematical models of HIV dynamics at four levels (host population ...	C22
35	7,148	Restenosis after balloon angioplasty. A practical proliferative model in porcine coronary arteries. A model of proliferative human restenosis was developed in domestic pigs by using deep injury to the coronary arterial media. Metal wire coils were delivered percutaneously to the coronary arteries of 11 pigs with an o...	C22
36	2,635	A comparison of host responses of the Mongolian jird to infections of Brugia malayi and B. pahangi. Host responses of jirds receiving a single subcutaneous inoculation of subperiodic Brugia malayi were compared with those of jirds similarly infected with B. pahangi. Parasite burdens, lymphatic lesion severity, granu...	C22
37	9,710	Modulation of fluid absorption and the secretory response of rat jejunum to cholera toxin by dietary fat. To study the effects of dietary fat on jejunal water and ion absorption and on cholera toxin-induced secretion, 3 week old Sprague Dawley rats were fed isocaloric diets. Forty per cent of the total calories were ...	C22
38	570	A comparison in vitro of human and rabbit distal colonic muscle responses to inflammatory mediators. The present study compared in vitro the motor responses of human and rabbit distal colonic longitudinal and circular muscle to acetylcholine, histamine, leukotrienes B4 and D4, and prostaglandins E2 and F2 alpha. The ...	C22
39	5,634	An epidemic outbreak of cryptosporidiosis: a prospective community study from Guinea Bissau. In the first year of a prospective community study of childhood diarrhea conducted in a semiurban area in the capital of Guinea Bissau, Cryptosporidium sp. was found in 73 (6.0%) of 1216 episodes of diarrhea. The parasite wa...	C22
40	3,074	Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis. Levels of tissue inhibitor of metalloproteases (TIMP) and plasminogen activator (PA)/plasmin were measured and the distribution of PA was studied by immunohistochemical techniques in c...	C22
41	6,090	Moderate hypothermia after cardiac arrest of 17 minutes in dogs. Effect on cerebral and cardiac outcome. Moderate hypothermia (30 degrees C) induced before circulatory arrest is known to improve neurologic outcome. We explored, for the first time in a reproducible dog outcome model, moderate hypothermia induced durin...	C22
42	5,472	Effect of dosage and timing of administration of naloxone on outcome in the rat ventral compression model of spinal cord injury. The effect of the dosage and timing of administration of naloxone after spinal cord injury in rats via the ventral compression technique is presented. The rat ventral compression technique ...	C22
43	933	Heart rate variability before and after myocardial infarction in conscious dogs at high and low risk of sudden death. Heart rate variability has been demonstrated both experimentally and clinically to be of prognostic importance in determining mortality after myocardial infarction. However, no paired studies have bee...	C22
44	3,220	Critical volume for pulmonary acid aspiration: reappraisal in a primate model. We have studied, in the monkey, the critical volume for the production of severe pneumonitis following pulmonary aspiration of gastric contents. Aspiration of 0.4 ml kg-1 and 0.6 ml kg-1 at pH1 produced mild to moderate clinical and radiol...	C22
45	6,661	Manual translaryngeal jet ventilation and the risk of aspiration in a canine model. STUDY OBJECTIVES: Manual translaryngeal jet ventilation (TLJV) is a safe and effective method of maintaining normal ventilation in apneic subjects. Little data exist on the amount of airway protection afforded with this technique of a...	C22
46	7,384	Experimental retinal branch vein occlusion in miniature pigs induces local tissue hypoxia and vasoproliferative microangiopathy. In miniature pigs, retinal veins were experimentally occluded using argon laser coagulation. Microvascular modifications leading to retinal hemorrhages and retinal edema were observed some ...	C22
47	2,032	Protection from chemotherapy-induced alopecia in a rat model. Alopecia (hair loss) is among the most distressing side effects of cancer chemotherapy. Little progress has been made, however, in its prevention or treatment, partly because of the lack of suitable experimental model. In recent work on the treatment of m...	C22
48	3,106	Bretylium tosylate versus lidocaine in experimental cardiac arrest Bretylium tosylate has been shown effective in the treatment of ventricular fibrillation and in the prevention of its recurrence. However, lidocaine is generally preferred because bretylium could have adverse hemodynamic effects related to its antiad...	C22
49	90	Reproduction of transfusion-related acute lung injury in an ex vivo lung model Leukoagglutinins are implicated in transfusion-related acute lung injury (TRALI). In the present study, severe lung vascular leakage was reproduced by application of a leukoagglutinating antibody of anti-5b specificity in an ex vivo lung ...	C22
50	3,940	Inhibition of hepatic glucose production by SDZ 51641. The new oral hypoglycemic agent SDZ 51641 was evaluated in nondiabetic rats and a rat model of human non-insulin-dependent diabetes mellitus. Diabetes was induced with a single injection of 37.5 mg/kg streptozocin, and the rats exhibited hyperglycemia in the fed ...	C22
51	7,502	A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. The virus has not been classified because neither an infectious particle nor a specific nucleic acid had been identified. To identify th...	C22
52	5,985	A mouse model of the aniridia-Wilms tumor deletion syndrome. Deletion of chromosome 11p13 in humans produces the WAGR syndrome, consisting of aniridia (an absence or malformation of the iris), Wilms tumor (nephroblastoma), genitourinary malformations, and mental retardation. An interspecies backcross between Mus musc...	C22
53	795	Synergism between hepatic injuries and a nonhepatotropic reovirus in mice. Enhanced hepatic infection and death. Reovirus type 1, after intravenous inoculation in the adult mouse, is secreted via bile into the intestine in an infectious form. Although reovirus type 1 is rapidly removed from systemic circulation by th...	C22
54	2,631	Endemic Cryptosporidium and Giardia lamblia infections in a Thai orphanage. We conducted a point prevalence survey for enteric protozoa in 205 institutionalized orphans 1-61 months of age in Bangkok, Thailand. Cryptosporidium was identified in 17 children (8%), Giardia lamblia in 42 (20%), and 3 children (1%) had bot...	C22
55	368	Peripheral venous monitoring with acute blood volume alteration: cuff-occluded rate of rise of peripheral venous pressure. We investigated the use of a new peripheral hemodynamic monitoring technique, the cuff-occluded rate of rise of peripheral venous pressure (CORRP), in the assessment of volume status in fluid over...	C22
56	4,611	Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders. The ability to specifically target gene expression to the epidermis of transgenic mice offers the exciting possibility of creating animal models of certain skin disorders that are inherited in man. It may ...	C22
57	6,119	Focal ischemic damage is reduced by CPP-ene studies in two animal models. We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia. In the cat middle cerebral artery occlusion model (6 hours' survival), pretreatment with D-CPP-e...	C22
58	344	Studies on the contact sensitizing activity of dithranol (anthralin) and 10-butyryl dithranol (butantrone). The contact sensitizing activity of dithranol and butantrone (10-butyryl dithranol) was studied in 3 animal models: the guinea pig maximization test (GPMT), the closed patch test (CPT), and the mouse ear swellin...	C22
59	5,432	A rat femoral artery model for vasospasm. A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were ...	C22
60	8,080	Experimental cardiac tamponade: correlation of pressure, flow velocity, and echocardiographic changes. Seven episodes of experimental cardiac tamponade were induced in five anesthetized closed-chest dogs. Simultaneous pericardial and intracavitary pressures were synchronized with superior vena caval and transvalvular...	C22
61	4,687	Exacerbation of acute platelet thrombus formation in stenosed dog coronary arteries with smoke from a non-tobacco-burning cigarette. The tobacco industry proposes to release a "new" cigarette with a burning charcoal tip, which heats the tobacco as air is drawn through it and into the lungs of the smoker. It is claime...	C22
62	8,727	Immunobiological studies on the alopecic (DEBR) rat. The Dundee experimental bald rat (DEBR) has been proposed as an animal model of human alopecia areata, which is suspected of being an autoimmune disease. This study was carried out to establish whether the immunological changes observed in the lesional DEBR rat cor...	C22
63	7,863	Platelet-activating factor: evidence against a role in hypoxic pulmonary vasoconstriction. The mechanism of hypoxic pulmonary vasoconstriction (HPV) remains unknown. The platelet-activating factor (PAF) antagonist WEB 2086 attenuated HPV in the isolated lung model of the rat. We evaluated the effect of WEB 2086 on H...	C22
64	6,122	Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat. Recent in vitro and in vivo experiments have suggested that excitatory amino acid antagonists, particularly those active at the N-methyl-D-aspartate receptor subtype, are effective in ameliorating is...	C22
65	2,747	Effects of a 2.15-micron laser on human atherosclerotic xenografts in vivo. The thulium-holmium-chromium:yttrium-aluminum-garnet (THC:YAG) laser has a tissue effect similar to that of the CO2 laser, with the advantage of transmissibility through flexible fibers. The authors used a human-rabbit xenograft model to eval...	C22
66	349	Low allergenicity of clonidine impedes studies of sensitization mechanisms in guinea pig models. During clinical trials, a clonidine transdermal device has been found to induce clonidine-specific allergic contact dermatitis in up to 25% of patients during a treatment period of 1 year. Using 3 different guinea pig str...	C22
67	4,626	Properties of strains of Escherichia coli O26:H11 in relation to their enteropathogenic or enterohemorrhagic classification. Thirty-seven strains of Escherichia coli O26:H11 from infants and calves with diarrhea were examined for properties associated with enteropathogenic (EPEC) or enterohemorrhagic E. coli (EHEC). ...	C22
68	9,078	Evidence against a requisite role for defective virus in the establishment of persistent hepadnavirus infections. The factors involved in the establishment of persistent hepadnavirus infection are poorly understood. Recent findings demonstrate that the sequence of the genome of hepatitis B virus (HBV) is variable in ...	C22
69	569	A small animal model of human Helicobacter pylori active chronic gastritis. Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacte...	C22
70	2,188	Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment wi...	C22
71	6,399	A simplified technique for the production of heart failure in the dog by rapid ventricular pacing. Prolonged rapid ventricular pacing (VP) in dogs produces low output heart failure (HF) characterized by cardiomegaly, ascites, and elevated plasma renin and norepinephrine levels. Commercially available pacemaker genera...	C22
72	7,701	The natural history of intimal flaps in a canine model. The natural history of arterial intimal flaps has not been well defined. This study characterizes the natural history of unrepaired intimal flaps. Thirty-nine 1-, 2-, and 3-mm hemispheric, distally based intimal flaps were made in 4- to 5-mm diameter canine fem...	C22
73	2,593	Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness. The objectives of this study were to determine the kinetics of Sendai virus-induced increases in bronchiolar mast cells and to determine whether virus-induced increases in bronchiolar mast cells we...	C22
74	9,349	Overestimation of myocardial infarct size by histologic measurement in a model of occlusion followed by reperfusion. We studied 32 transverse left ventricular slices of myocardium from 16 pigs after 45 to 100 minutes of coronary artery occlusion followed by 180 minutes of reperfusion. Infarct area for each slice was ...	C22
75	7,526	Magnetic resonance imaging of experimental rat brain tumors: histopathological evaluation. Using RG-C6 glioma-transplanted rats, we studied precontrast and postcontrast magnetic resonance imaging, extravasation of Evans blue, and histology. In all rats, tumor was enhanced with gadolinium-diethylenetriaminepentaacetic...	C22
76	6,077	Adoptive immunotherapy of human pancreatic cancer with lymphokine-activated killer cells and interleukin-2 in a nude mouse model. A pancreatic cancer cell line was grown in orthotopic and heterotopic positions in young Swiss/NIH nude mice, which were tested with adoptive immunotherapy. Mice were injected with 1 x 10(...	C22
77	8,116	Cytomegalovirus infection promotes bacterial translocation in thermally injured mice. Thermally injured mice that were given intraperitoneal injections of murine cytomegalovirus (MCMV) appeared to be clinically septic and to have increased mortality rates. To evaluate the possible role of MCMV infection in promoting ...	C22
78	365	Role of prostaglandin E1 in reducing pulmonary vascular resistance in an experimental model of acute lung injury. To determine the role and efficacy of prostaglandin E1 (PGE1) on the cardiopulmonary derangements induced by glass bead embolism, two studies were performed. In the first study, a dose response of PGE1 wa...	C22
79	8,833	Metabolic regulation of renal gluconeogenesis in response to sepsis in the rat. 1. The regulation of renal gluconeogenesis was studied in rats made septic by a caecal ligation and puncture technique. 2. Blood glucose concentrations were not markedly different in septic rats, but lactate, pyruvate and alanine concen...	C22
80	3,325	Effect of bladder outflow obstruction on the innervation of the rabbit urinary bladder. The effects of bladder outflow obstruction on the innervation of the bladder were studied using a rabbit animal model. Partial occlusion of the bladder neck was obtained by the placement of a silk ligature at that level; control a...	C22
81	2,869	In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs. Sporozoites of Cryptosporidium parvum which were excysted in vitro from oocysts isolated from calves or patients with acquired immune deficiency syndrome underwent development in monolayers of the mouse fibroblast cell line L92...	C22
82	4,986	Effect of endotoxin and a burn injury on lung and liver lipid peroxidation and catalase activity. Both endotoxin and a burn alone produce oxidant-induced tissue lipid peroxidation. The endotoxin response is due in large part to hydrogen peroxide. The combination of endotoxin after a burn results in an increased live...	C22
83	3,960	Inducement by fat feeding of basal hyperglycemia in rats with abnormal beta-cell function. Model for study of etiology and pathogenesis of NIDDM. Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogenous disorder characterized by defects in insulin action and secretion. This study was aimed at developing a ra...	C22
84	7,333	One hundred percent oxygen reverses muscle hypoxia in a rat hindlimb model of acute arterial occlusion. Significant morbidity results from extremity ischemia after acute arterial occlusion. Reestablishment of arterial flow is considered to be the ideal treatment, yet substantial tissue loss can occur before this is a...	C22
85	3,368	Risk of occupational exposure to Herpesvirus simiae (B virus) in Quebec. Herpesvirus simiae (B virus) causes a mild infection in macaques. Transmission to humans may result in life-threatening encephalomyelitis. To evaluate the risk of occupational exposure to B virus we surveyed the directors of 11 biomedical labor...	C22
86	4,615	Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses. Nearly 100 mouse mutations have been described as causing some type of abnormality of the skin or hair. As only a few of these mutations have been studied in detail, they remain an untapped resource for furthering know...	C22
87	4,302	Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic. A filovirus, serologically related to Ebola virus, was detected by "post-embedment" immunoelectron microscopical examination of MA-104 cells. These had been infected by inoculation with serum samples obtained during the 1989...	C22
88	3,070	Systemic amiloride inhibits experimentally induced neovascularization. Amiloride is an inhibitor of urokinase-type plasminogen activator, and might therefore have an inhibitory effect on neovascularization. Neovascularization was induced in rabbit corneas via local implantation of prostaglandin E1 pellets prepared in...	C22
89	325	Animal models of chronic inflammatory arthritis. The use of animals has been indispensable to the investigation of the etiology, pathophysiology, and treatment of juvenile arthritis. Because of ethical concerns about studying children, the difficulty of obtaining tissue, and the heterogeneous manifestations and prote...	C22
90	7,117	Pathophysiological insights into the cardiomyopathy of Chagas' disease. The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, the ultimate ex...	C22
91	2,126	Experimental isobaric subarachnoid hemorrhage: regional mitochondrial function during the acute and late phase. Patients treated for aneurysmal subarachnoid hemorrhage show, in the long-term follow up, an elevated rate of cognitive disturbances that are mainly related to the impact of the initial bleeding: the neuroto...	C22
92	8,845	Causes, diagnosis, and treatment of pharyngitis. Pharyngitis is a common disease of the respiratory tract that can be caused by several different viruses and bacterial organisms. Clinically speaking, the most important causative agent is group A streptococcus (Streptococcus pyogenes). Although rare, postpharyngitis ...	C02
93	2,060	Assessing the risk of occupational acquisition of the human immunodeficiency virus: implications for hospital policy. In determining infection control policy, it is essential to quantitatively assess the risk of transmission of human immunodeficiency virus (HIV) to health care workers and their families. The risk sho...	C02
94	5,602	Diagnosis of oral hairy leukoplakia by ultrastructural examination of exfoliative cytologic specimens. Lingual exfoliative cytologic specimens (scrapings) were obtained from 18 patients positive for human immunodeficiency virus with clinical oral hairy leukoplakia. Buccal mucosal scrapings were obtained from 12 of th...	C02
95	8,503	Granulomatous Pneumocystis carinii pneumonia in a patient with the acquired immunodeficiency syndrome. A patient with an unusual granulomatous response to infection with Pneumocystis carinii is described. The diagnosis was made by open lung biopsy after two negative bronchoalveolar lavages.	C02
96	4,650	Distribution and specific identification of papillomavirus major capsid protein epitopes by immunocytochemistry and epitope scanning of synthetic peptides. Monoclonal (MAbs) and polyclonal antibodies were produced against the major capsid protein of detergent-disrupted, purified bovine papillomavirus type 1 (BPV-1). ...	C02
97	4,656	Pichinde virus infection in strain 13 guniea pigs reduces intestinal protein reflection coefficient with compensation. Pichinde virus inoculation into strain 13 guinea pigs is a model with features reputed to be similar to hemorrhagic fever in humans. Although the infection is lethal by day 13-19, guinea pigs of appr...	C02
98	8,313	The emergence of hepatitis B as a sexually transmitted disease. In the United States, approximately 300,000 cases of hepatitis B virus infection occur annually, and heterosexual activity is one of the most commonly reported risk factors for acquiring disease. Until the number of infections transmitted through heteros...	C02
99	7,381	Acute syphilitic posterior placoid chorioretinitis. Six patients with evidence of secondary syphilis presented with visual loss in both eyes caused by large, placoid, yellowish lesions with faded centers at the level of the pigment epithelium in the macula and juxtapapillary areas. All eyes had vitreitis. All of the...	C02

End of preview. Expand in Data Studio

Dataset Card for Ohsumed

Ohsumed collection (available at ftp://medir.ohsu.edu/pub/ohsumed): it includes medical abstracts from the MeSH categories of the year 1991. In [Joachims, 1997] were used the first 20,000 documents divided in 10,000 for training and 10,000 for testing. The specific task was to categorize the 23 cardiovascular diseases categories. After selecting such category subset, the unique abstract number becomes 13,929 (6,286 for training and 7,643 for testing). As current computers can easily manage larger number of documents we make available all 34,389 cardiovascular diseases abstracts out of 50,216 medical abstracts contained in the year 1991.

Download Here:

Cardiovascular diseases abstracts (in the first 20,000 abstracts of the year 1991)

Citation Information

Hersh WR, Buckley C, Leone TJ, Hickam DH, OHSUMED: An interactive retrieval evaluation and new large test collection for research, Proceedings of the 17th Annual ACM SIGIR Conference, 1994, 192-201.
Hersh WR, Hickam DH, Use of a multi-application computer workstation in a clinical setting, Bulletin of the Medical Library Association, 1994, 82: 382-389.
Alessandro Moschitti, A study on optimal parameter tuning for Rocchio text classifier. In proceedings of the 25th European Conference on Information Retrieval Research (ECIR 2003), Pisa, Italy, April, 2003.

Downloads last month: 10

Models trained or fine-tuned on cglez/ohsumed

cglez/bert-base-uncased-ft-ohsumed

Text Classification • 0.1B • Updated Nov 24, 2025 • 2