id stringlengths 10 13 | question_id stringlengths 10 13 | document_id stringlengths 10 13 | question stringlengths 23 23 | type stringclasses 1
value | choices list | context stringlengths 8.99k 109k | answer list |
|---|---|---|---|---|---|---|---|
MH_train_1600 | MH_train_1600 | MH_train_1600 | interacts_with DB04844? | multiple_choice | [
"DB00208",
"DB00286",
"DB01126",
"DB01248",
"DB01276",
"DB01283",
"DB03516",
"DB04971",
"DB06809"
] | Agonists and antagonists for P2 receptors . Recent work has identified nucleotide agonists selective for P47900 , P41231 and Q15077 receptors and nucleotide antagonists selective for P47900 , Q9H244 and P51575 receptors . Selective non-nucleotide antagonists have been reported for P47900 , P41231 , Q15077 , Q9H244 , Q9... | [
"DB00208"
] |
MH_train_1601 | MH_train_1601 | MH_train_1601 | interacts_with DB00834? | multiple_choice | [
"DB00594",
"DB00918",
"DB01628",
"DB05255",
"DB05507",
"DB06101",
"DB08805",
"DB08888",
"DB09036"
] | A new clinical evidence-based gene-environment interaction model of depression . In our current understanding of mood disorders , the role of genes is diverse including the mediation of the effects of provoking and protective factors . Different or partially overlapping gene sets play a major role in the development of... | [
"DB09036"
] |
MH_train_1602 | MH_train_1602 | MH_train_1602 | interacts_with DB00215? | multiple_choice | [
"DB00173",
"DB00898",
"DB01064",
"DB01269",
"DB02116",
"DB03501",
"DB04894",
"DB05759",
"DB07232"
] | Local control of alpha1-proteinase inhibitor levels : regulation of alpha1-proteinase inhibitor in the human cornea by growth factors and cytokines . Alpha 1-proteinase inhibitor is a major serine proteinase inhibitor in the human cornea involved in the protection of the avascular corneal tissue against proteolytic dam... | [
"DB00898"
] |
MH_train_1603 | MH_train_1603 | MH_train_1603 | interacts_with DB06684? | multiple_choice | [
"DB00051",
"DB00945",
"DB01373",
"DB03424",
"DB05229",
"DB05239",
"DB06080",
"DB08954",
"DB09045"
] | P09917 pathway promotes cell proliferation in human glioma cell lines . OBJECTIVE : P09917 ( P09917 ) is a key enzyme in the synthesis of leukotrienes ( LTs ) , that might promote carcinogenesis . We investigated P09917 expression and examined whether the P09917 pathway is associated with the proliferation of human bra... | [
"DB00945"
] |
MH_train_1604 | MH_train_1604 | MH_train_1604 | interacts_with DB00072? | multiple_choice | [
"DB00143",
"DB00197",
"DB00244",
"DB01084",
"DB01780",
"DB04829",
"DB05223",
"DB06273",
"DB09043"
] | 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and P25963 degradation in rat chondrocytes through a PPARgamma-independent pathway . P37231 ( PPARgamma ) ligands have been shown to inhibit the effects of proinflammatory cytokines such as interleukin-1beta ( IL-1beta ) . This cy... | [
"DB06273"
] |
MH_train_1605 | MH_train_1605 | MH_train_1605 | interacts_with DB06643? | multiple_choice | [
"DB00146",
"DB00153",
"DB00887",
"DB03615",
"DB04599",
"DB04957",
"DB06692",
"DB08895",
"DB08901"
] | Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon . Considerable evidence exists to support the use of vitamin D to prevent and/or treat colorectal cancer . However , the routine use of bioactive vitamin D , 1,25-dihydroxyvitamin D3 , is limited by the si... | [
"DB08895"
] |
MH_train_1606 | MH_train_1606 | MH_train_1606 | interacts_with DB00864? | multiple_choice | [
"DB00050",
"DB00067",
"DB00167",
"DB01113",
"DB02424",
"DB03073",
"DB05243",
"DB09036",
"DB11582"
] | Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin . DB00067 ( VP ) binds to the vasopressin type 2 receptor ( P30518 ) to trigger physiological effects including body fluid homeostasis and blood pressure regulation . Signaling is terminated by receptor downregulation involving clathri... | [
"DB09036"
] |
MH_train_1607 | MH_train_1607 | MH_train_1607 | interacts_with DB00834? | multiple_choice | [
"DB00171",
"DB00855",
"DB01131",
"DB01599",
"DB02383",
"DB04852",
"DB04864",
"DB05374",
"DB06273"
] | DB06273 in pediatric rheumatology : the clinical experience . During the last two decades , clinical use of novel biological therapy has led to increased mechanistic understanding of complex rheumatological diseases . Conversely , basic and translational studies have led to development of new and varied therapeutic age... | [
"DB06273"
] |
MH_train_1608 | MH_train_1608 | MH_train_1608 | interacts_with DB00864? | multiple_choice | [
"DB00055",
"DB00083",
"DB00091",
"DB00580",
"DB01006",
"DB05511",
"DB06062",
"DB06785",
"DB08836"
] | Nox2 and Nox4 mediate tumour necrosis factor-α-induced ventricular remodelling in mice . Reactive oxygen species ( ROS ) and pro-inflammatory cytokines are crucial in ventricular remodelling , such as inflammation-associated myocarditis . We previously reported that tumour necrosis factor-α ( P01375 -α ) -induced ROS i... | [
"DB00091"
] |
MH_train_1609 | MH_train_1609 | MH_train_1609 | interacts_with DB01211? | multiple_choice | [
"DB00151",
"DB00688",
"DB00981",
"DB00987",
"DB01221",
"DB02533",
"DB05030",
"DB05790",
"DB06695"
] | Recombinant human prothrombin kringles have potent anti-angiogenic activities and inhibit Lewis lung carcinoma tumor growth and metastases . P00734 , a protein involved in blood coagulation , is a plasma glycoprotein composed of the Gla domain , two adjacent kringle domains , and a serine protease domain . Kringles are... | [
"DB06695"
] |
MH_train_1610 | MH_train_1610 | MH_train_1610 | interacts_with DB06643? | multiple_choice | [
"DB00144",
"DB00174",
"DB01643",
"DB02351",
"DB05007",
"DB05225",
"DB05258",
"DB05304",
"DB06273"
] | β-cryptoxanthin regulates bone resorption related-cytokine production in human periodontal ligament cells . OBJECTIVE : β-cryptoxanthin ( β-cry ) is a type of carotenoid found in certain fruits and vegetables . Although it has been shown that β-cry inhibits alveolar bone resorption , the molecular mechanisms for this h... | [
"DB06273"
] |
MH_train_1611 | MH_train_1611 | MH_train_1611 | interacts_with DB00215? | multiple_choice | [
"DB00045",
"DB00116",
"DB01045",
"DB01079",
"DB01257",
"DB03800",
"DB05311",
"DB05343",
"DB06813"
] | Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550 : a pilot study in de novo kidney allograft recipients . This randomized , pilot study compared the Janus kinase inhibitor CP-690,550 ( 15 mg P55957 [ CP15 ] and 30 mg P55957 [ CP30 ] , n = 20 each ) with tacrolimus ( n = 21 ) in de novo... | [
"DB01045"
] |
MH_train_1612 | MH_train_1612 | MH_train_1612 | interacts_with DB04844? | multiple_choice | [
"DB00200",
"DB00215",
"DB00519",
"DB00711",
"DB01199",
"DB02877",
"DB05465",
"DB05897",
"DB06155"
] | P01308 -like growth factor-I treatment of children with Laron syndrome ( primary growth hormone insensitivity ) . Laron syndrome ( LS , congenital primary GH insensitivity ) is caused by deletions or mutations in the P10912 gene , resulting in an inability to generate insulin-like growth factor-I ( P05019 ) . If untrea... | [
"DB00215"
] |
MH_train_1613 | MH_train_1613 | MH_train_1613 | interacts_with DB06643? | multiple_choice | [
"DB00091",
"DB00094",
"DB00138",
"DB01541",
"DB02621",
"DB02712",
"DB05005",
"DB05692",
"DB06096"
] | Connexin 43 and P29323 regulate tension-induced signal transduction in human periodontal ligament fibroblasts . Periodontal ligament ( PDL ) fibroblasts play an important role in preserving periodontal homeostasis and transmitting mechanical signals to alveolar bone . Connexin 43 ( P17302 ) , a gap junction protein , i... | [
"DB00091"
] |
MH_train_1614 | MH_train_1614 | MH_train_1614 | interacts_with DB01211? | multiple_choice | [
"DB00082",
"DB01901",
"DB02010",
"DB04223",
"DB04942",
"DB05876",
"DB06016",
"DB06196",
"DB06273"
] | Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis . Proper CNS function depends on concerted expression of thousands of genes in a controlled and timely manner . Traumatic brain injury ( TBI ) in mammals results in neuronal death and neurological dysfunc... | [
"DB06273"
] |
MH_train_1615 | MH_train_1615 | MH_train_1615 | interacts_with DB00834? | multiple_choice | [
"DB00091",
"DB00360",
"DB01186",
"DB01404",
"DB04849",
"DB04892",
"DB05463",
"DB05822",
"DB06698"
] | Agonism at P41595 receptors is not a class effect of the ergolines . Restrictive cardiac valvulopathies observed in Parkinson patients treated with the ergoline dopamine agonist pergolide have recently been associated with the agonist efficacy of the drug at 5-hydroxytryptamine2B ( P41595 ) receptors . To evaluate whet... | [
"DB00091"
] |
MH_train_1616 | MH_train_1616 | MH_train_1616 | interacts_with DB00864? | multiple_choice | [
"DB00010",
"DB00275",
"DB00451",
"DB00533",
"DB01045",
"DB01407",
"DB01411",
"DB03147",
"DB07863"
] | beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells . Although the pharmacological role of beta-carotene in the prevention and treatment of many cancer cells has received increasing attention , the mole... | [
"DB01045"
] |
MH_train_1617 | MH_train_1617 | MH_train_1617 | interacts_with DB00215? | multiple_choice | [
"DB00128",
"DB00583",
"DB00733",
"DB00945",
"DB01157",
"DB01819",
"DB02272",
"DB04912",
"DB05241"
] | Whole blood lead concentration and erythrocyte delta-aminolevulinic acid dehydratase ( P13716 ) activity in selected canine populations in Greece . In a total number of 275 dogs of various ages , sex and breed , blood lead concentrations ( O43927 ) and erythrocyte P13716 activity were measured . Sixty-six of the dogs w... | [
"DB00945"
] |
MH_train_1618 | MH_train_1618 | MH_train_1618 | interacts_with DB01211? | multiple_choice | [
"DB00091",
"DB00142",
"DB00995",
"DB01213",
"DB03783",
"DB04630",
"DB05220",
"DB05595",
"DB05829"
] | DB00227 -stimulated superinduction of P16581 , P05362 and P19320 in P01375 activated human vascular endothelial cells . Inhibitors of P04035 ( statins ) reveal important pharmacological effects in addition to reducing the plasma LDL cholesterol level . In the pathogenesis of arteriosclerosis , transendothelial migratio... | [
"DB00091"
] |
MH_train_1619 | MH_train_1619 | MH_train_1619 | interacts_with DB01211? | multiple_choice | [
"DB00140",
"DB00154",
"DB00947",
"DB01045",
"DB01185",
"DB01262",
"DB04799",
"DB04956",
"DB06243"
] | Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC-MS/MS : first evidence of DNA methylation in Caenorhabditis elegans . From 1986 to the present , the popular research model organism Caenorhabditis elegans has been thought to completely lack DNA methylation and seems to have los... | [
"DB01045"
] |
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