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PMC10786460 | 38223395 | Introduction
“Aging with Disability” is a term that refers to people living with the long-term effects of disabilities acquired early in life who are now surviving into mid- and later life [ 1 ]. Increased life expectancy among those with disabilities acquired at birth (e.g., cerebral palsy, spina bifida) is attributed... | Materials and Methods
Data Source and Analytical Cohort
Data for this study were obtained from Optum’s de-identified Clinformatics ® Data Mart (CDM) Database (2007–2018). This is a nationwide, single private payer, administrative health claims database for over 80 million beneficiaries with commercial and Medicare Adv... | Results
Descriptive statistics for the study cohort are presented in Table 1 by levels of care continuity. Individuals aging with CP/SB were around 50 years of age on average and 59% were female. Individuals had almost 3 comorbid health conditions on average. The mean COC score was 0.30 overall. Amongst individuals w... | Discussion
In this large nation-wide cohort of members from large commercial and Medicare Advantage health plans in the United States, we provide one of the first characterizations of COC in adults aging with CP/SB, and highlight how proximity to health care facilities, availability of care providers, and community soc... | Conclusions
Collectively, these findings suggest that individuals aging with CP/SB represent a population particularly prone to fragmented care, perhaps more so than other complex-care populations. Adults living with pediatric onset disabilities in the United States report challenges accessing appropriate care once the... | Author Contributions: Conceptualization, A.M.K., E.M. and P.C.; Formal analysis, A.M.K. and P.L.; Methodology, A.M.K., P.L., N.K. and E.M.; Resources, N.K.; Supervision, P.C.; Writing—original draft, A.M.K.; Writing—review & editing, A.M.K., P.L., N.K., E.M. and P.C. All authors have read and agreed to the published v... | Supplementary Material | Funding:
The contents of this manuscript were developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant number 90RTHF0001). NIDILRR is a Center within the Administration for Community Living (ADL), Department of Health and Human Services (HHS). The... | CC BY | no | 2024-01-16 23:35:04 | Disabilities (Basel). 2023 Jun 12; 3(2):295-306 | oa_package/97/ba/PMC10786460.tar.gz |
PMC10786622 | 38223535 | Background
The widespread adoption of electronic health records (EHRs) affords an unprecedented opportunity to leverage clinical data for research. EHRs contain a large amount of clinical information that, when combined with other data sources such as ‘omics, enhances the potential for research discovery. The secondary... | Conclusions
In summary, this review considers the advantages, potential drawbacks, and approaches to utilize EHR data for secondary research. We discuss methods to optimize efficiency in obtaining large amounts of data while protecting patient privacy, methodological and statistical considerations to maintain data inte... | Authors’ contributions
CA wrote the manuscript; BS provided a preliminary draft of the manuscript; FM, AV, RP, EZ, and ME provided a critical review of the manuscript; IB critically reviewed the manuscript and provided extensive edits; AM conceived of the idea for the manuscript and provided extensive edits. The author... | Main text
Overview of using EHR data for research
Data types and steps for data request
Data abstracted from the EHR for secondary use research falls broadly into three categories, each with specific compliance expectations. Datasets are classified as identified, limited, or de-identified. Identified data contains pers... | Funding
This work was funded by NIH grants, F32HL160123 (CA) R35GM124939 (AAM) and CTSI UL1 TR001082.
Availability of data and materials
Not applicable.
Abbreviations
Electronic health record
Institutional review board
Health Data Compass
Personal health information
Information technology | CC BY | no | 2024-01-16 23:35:02 | Transl Med Commun. 2023 Mar 2; 8:7 | oa_package/cf/bf/PMC10786622.tar.gz | |||
PMC10786681 | 0 | Physician and geneticist Dr. Funmi Olopade is the founding director of the Center for Cancer Genetics and Global Health at the University of Chicago ( Figure 1 ). Olopade’s research is focused on gaining a better understanding of the root causes and genomic basis of cancer in diverse populations. She is internationally... | 01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e178495 | oa_package/01/04/PMC10786681.tar.gz | ||||||
PMC10786682 | 0 | Over several decades the JCI has published key advances in our understanding of glucagon-like peptide 1 (GLP-1) biology. The first incretin peptide characterized in the 1970s, glucose-dependent insulinotropic polypeptide (GIP), was isolated from porcine gastric extracts. Subsequently, the sequence of GLP-1 was identi... | DJD is supported by a Banting and Best Diabetes Centre-Novo Nordisk Chair in Incretin Biology, a Sinai Health Novo Nordisk Foundation Fund in Regulatory Peptides, and CIHR Foundation Grant 154321.
01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e175634 | oa_package/03/0e/PMC10786682.tar.gz | ||||||
PMC10786683 | 0 | Conclusions and future prospective
CAR-T cells have been transformative for B-cell acute lymphoblastic leukemias (ALL) and NHL. As we extend the benefits of CAR-T cells to other hematologic malignancies, new CARs and combinations are taking the stage, and additional challenges are emerging. More toxicities with new tar... | An advanced treatment for hematological malignancies
For decades, the success of allogeneic hematopoietic stem cell transplant has highlighted the role of T cells in eliminating hematological tumors. This proof of concept pioneered the practice of the ex vivo generation and adoptive transfer of tumor-specific T cells (... | 01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e177160 | oa_package/0e/f5/PMC10786683.tar.gz | |||||
PMC10786684 | 37943622 | To the Editor: Dilated cardiomyopathy (DCM) and peripartum cardiomyopathy frequently associate with heterozygous truncating variants in TTN ( TTN tvs) (1). TTN codes for titin, a spring-like protein that spans the sarcomere from the Z-disk to the M-line and is essential for sarcomeric assembly, homeostasis, and regu... | This work was supported by the National Heart, Lung and Blood Institute (NHLBI) (HL152446, HL126797, HL149891); the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) T-32 (AR-53461-12); the Children’s Hospital of Philadelphia Frontier Program; the Foundation Leducq (research grant 20CVD01); ... | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e170196 | oa_package/c3/d0/PMC10786684.tar.gz | ||||||
PMC10786685 | 0 | Conclusions and implications
By uncovering distinct mechanisms and essential roles for SEL1L and HRD1 variants, these exciting findings by Qi and colleagues raise intriguing new questions, answers to which should generate further insights into ERAD mechanisms that promote proteostasis. For example, impaired ERAD functi... | The suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) complex of the endoplasmic reticulum–associated degradation (ERAD) machinery is a key cellular proteostasis pathway. Although previous studies have shown ERAD as promoting the development and maintenance of many cell types in mice, its importanc... | ERAD pathway proteins
The endoplasmic reticulum (ER) is a major site of protein synthesis, folding, and maturation for membrane and secreted proteins. It is therefore imperative to have ER-intrinsic quality-control mechanisms that prevent accumulation of misfolded proteins in the ER lumen to prevent proteotoxic stress.... | Work in our laboratory is supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (ZIA BC 012135).
01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e175448 | oa_package/f2/05/PMC10786685.tar.gz | ||||
PMC10786686 | 37962956 | Introduction
Targeted metagenomic sequencing is commonly used for the identification of disease-causing bacteria, archaea, and fungi. In addition, 16S rRNA gene surveys are increasingly being adopted as diagnostic tools to profile microbiome communities that contribute to clinical pathogenesis ( 1 ). However, to unders... | Methods
Simulation of full-length and region-specific 16S amplicon data
Two reference databases were used for data simulation: the NCBI 16S rRNA RefSeq database (downloaded in July 2019) and the Ribosomal Database Project (RDP) database (release 11.5) ( 33 ). To extract sequence fragments as full-length amplicons of ta... | Results
Optimal sequence length for accurate taxonomic profiling of 16S amplicons.
Most pipelines that process 16S amplicon reads apply quality control (QC) procedures and trim the reads to short, equal lengths. This approach can introduce taxonomic and compositional bias ( Figure 1A ). An alternative method is to subm... | Discussion
The field of microbiome science is a rapidly evolving area of research. Recent advancements in sequencing strategies and bioinformatics have significantly improved our understanding of host-microbiota interactions ( 1 – 3 ). Nonetheless, it is important not to disregard the value of retrospective microbiome ... | Targeted metagenomic sequencing is an emerging strategy to survey disease-specific microbiome biomarkers for clinical diagnosis and prognosis. However, this approach often yields inconsistent or conflicting results owing to inadequate study power and sequencing bias. We introduce Taxa4Meta, a bioinformatics pipeline ex... | Author contributions
QW and TCS led the conceptualization and data interpretation of the study. QW, SB, SYS, and TJT performed the data acquisition and analysis. QW and TCS drafted the manuscript.
Supplementary Material | The authors thank the LifeLines data management team for providing access to the microbiome data of the LifeLines-Deep cohort, and EzBiome Inc. for granting access to the 16S MTP pipeline in EzBioCloud. This work was supported by NIH grants from the National Institute of Diabetes and Digestive and Kidney Diseases (P30-... | CC BY | no | 2024-01-16 23:40:16 | J Clin Invest.; 134(2):e170859 | oa_package/9e/dc/PMC10786686.tar.gz | |
PMC10786687 | 0 | Introduction
Cues from the innate immune system determine the priming, recruitment, and functionality of adaptive immunity. This crosstalk is generally mediated through antigen-independent pattern recognition receptor (PRR) signaling and results in costimulation, antigen presentation activity, and cytokine/chemokine si... | Since the discovery that cGAS/STING recognizes endogenous DNA released from dying cancer cells and induces type I interferon and antitumor T cell responses, efforts to understand and therapeutically target the STING pathway in cancer have ensued. Relative to other cancer types, the glioma immune microenvironment harbor... | Compartment-specific roles for STING signaling in the TME
While the importance of STING signaling in priming antitumor immunity is well established, less is known about the precise contributions of STING activation in the cells comprising the tumor and TME (i.e., neoplastic cells, immune cells, and stroma/vasculature) ... | GKF is supported by the US Food and Drug Administration (grant R01FD006368), Cannonball Kids Cancer Foundation, the Rally Foundation for Childhood Cancer Research, CureSearch for Children’s Cancer, The V Foundation for Cancer Research, Hyundai Hope on Wheels, Andrew McDonough B+ Foundation, the National Pediatric Cance... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e163452 | oa_package/80/93/PMC10786687.tar.gz | ||||
PMC10786688 | 38032738 | Introduction
Insulin resistance underlies the development of type 2 diabetes (T2D) and metabolic syndrome ( 1 – 3 ), which together affect 20%–30% of adults in Westernized populations ( 4 ). In addition, an almost equal fraction of nondiabetic people within the general population have been shown to have a level of insu... | Methods
Study participants, SSPG, and iPSC reprogramming.
The iPSC lines were generated from 20 human study participants who had been recruited and assessed for insulin sensitivity using steady-state plasma glucose (SSPG) obtained from the modified insulin suppression test at the Stanford Clinical and Translational Res... | Results
Transcriptional profiling reveals the cell-autonomous changes in gene expression associated with insulin resistance.
iPSCs were created from 20 individuals without diabetes, half in the top quintile of insulin sensitivity (I-Sen) and half in the bottom quintile of insulin sensitivity, i.e., most insulin resista... | Discussion
Insulin resistance is central to the pathophysiology of T2D, obesity, and metabolic syndrome. Insulin resistance can be identified in offspring of T2D parents many years prior to the onset of the disease and predicts disease development ( 3 ). In addition, insulin resistance is present in a substantial fract... | About 25% of people in the general population are insulin resistant, increasing the risk for type 2 diabetes (T2D) and metabolic disease. Transcriptomic analysis of induced pluripotent stem cells differentiated into myoblasts (iMyos) from insulin-resistant (I-Res) versus insulin-sensitive (I-Sen) nondiabetic individual... | Author contributions
NH designed and performed all the experiments, analyzed all the data, designed the figures, and wrote the paper. CRK conceived the study, helped with data analysis and interpretation, reviewed and edited the manuscript, and supervised the project. Both authors read, reviewed, and edited the manuscr... | We thank Kahn laboratory members, especially Thiago M. Batista and Ari Gattu, for discussions. We thank Bioinformatics Core members Hui Pan and Jonathan Dreyfuss at the Joslin Diabetes Center for help with the data analysis. Ivan Carcamo-Orive and Joshua W. Knowles provided the I-Sen and I-Res iPSC lines. This work was... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e172333 | oa_package/0a/47/PMC10786688.tar.gz | |
PMC10786689 | 0 | Authorship note: JTH and SGC contributed equally to this work.
Titin (TTN) is one of the largest and most complex proteins expressed in humans, and truncation variants are the most prevalent genetic lesion identified in individuals with dilated cardiomyopathy (DCM) or other disorders of impaired cardiac contractility.... | TTN structure and function
The sarcomere is the fundamental contractile unit of the myocyte and is commonly subdivided into Z-disc, I-band, A-band, and M-line regions, and the titin (TTN) protein spans half the sarcomere. The TTN gene has 364 exons (meta-transcript, Ensembl ID: ENST00000589042), which are differentia... | We thank Gloria Fuentes for assistance with figure design. Funding supported was obtained from the NIH (R01HL165220, to JTH and SGC).
01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e175206 | oa_package/2f/97/PMC10786689.tar.gz | |||||
PMC10786690 | 0 | Introduction
The relationship between the immune system and cancer growth is complex; the interplay between the immune system and the tumor impacts all aspects of cancer growth, from tumorigenesis to tumor growth and eventual metastasis. Such interaction between the immune system and the tumor is based on the theory of... | Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. The management of NSCLC has advanced substantially in recent years, with immunotherapeutic agents, such as immune checkpoint inhibitors (ICIs), leading ... | ICI biology
T cells are an integral part of the adaptive immune response; their activation by an offending antigen (e.g., an infectious agent or a tumor antigen) can propagate a series of inflammatory responses. In cancer, these antigens can arise from tumor cells; as such, T cells are known to be an important factor i... | 01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e170503 | oa_package/24/44/PMC10786690.tar.gz | ||||
PMC10786691 | 37943610 | Introduction
Nascent membrane or secretory proteins are synthesized and folded in the endoplasmic reticulum (ER), which is prone to misfolding. Such misfolding may have pathogenic consequences if not cleared effectively ( 1 - 5 ). The suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) complex repres... | Methods
Human subjects.
Six patients from 3 families were identified and included in the study. The patient cases were gathered through the web-based tool GeneMatcher ( 83 ) ( https://genematcher.org/statistics/ ). The Saudi Arabian boy was born in 10/2009 to a gravida 2, para 1, abortion 0 29-year-old healthy mother a... | Results
Identification of biallelic SEL1L and HRD1 variants in humans.
Six patients from 3 unrelated families in Saudi Arabia (patient 1), Morocco (patient 2–5), and Italy (patient 6) were suspected of inherited genetic disease during clinical visits ( Figure 1, A–C ). Patients 1, 2, 3, and 6 were subjected to WES of D... | Discussion
This study reports 3 variants in SEL1L and HRD1 genes in 6 patients from 3 unrelated families. These patients manifest similar clinical features, including developmental delay, microcephaly, intellectual disability, facial dysmorphism, hypotonia, and ataxia. Using KI HEK293T cells expressing individual v... | Authorship note: HHW, LLL, and ZJL contributed equally to this work.
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associate... | Author contributions
HHW and LLL designed and performed most experiments. ZJL generated all KI cells. XW performed structural analysis. OA, GC, MOH, LH, AM, MA, FSA, CB, KP, and NBP performed exome sequencing WES analysis, identified variants, and acquired clinical data. QP, SS, and MB provided insightful discussions. ... | We are deeply grateful to all patients and their families for their consent and willingness to participate in this study; Chih-Chi Andrew Hu (Houston Methodist Hospital) for reagents; members of the Qi, Arvan, and Pletcher laboratories; and Jiwon Hwang and Ryan Baldridge at the University of Michigan Medical School for... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e170054 | oa_package/5f/4c/PMC10786691.tar.gz | |
PMC10786692 | 37934611 | Introduction
ATR (ataxia telangiectasia and Rad3-related) is a critical kinase in the DNA damage response (DDR) ( 1 , 2 ). Preclinical data have identified multiple cancer-related phenotypes sensitizing tumor cells to monotherapy ATR inhibition (ATRi) ( 3 ). Additionally, ATRi potentiates DNA-damaging therapies, inclu... | Methods
Patient population.
Patients were 18 years and over, with advanced solid malignancy, without standard anticancer treatment options. All had Eastern Cooperative Oncology Group (ECOG) ( https://ecog-acrin.org/resources/ecog-performance-status/ ) performance status 0–1, life expectancy of at least 3 months, and ad... | Results
Patient characteristics
A total of 26 patients were enrolled and started ceralasertib in the dose-escalation phase across 3 centers between July 2014 and July 2016. In the dose-expansion phase, 43 patients were enrolled, of whom 41 received at least 1 dose of study drug (2 progressed prior to treatment start) b... | Discussion
Our study is the largest to date, to our knowledge, of ATRi monotherapy. We have shown that ceralasertib monotherapy is tolerable, with predominantly hematological toxicities reduced by an intermittent schedule. Ceralasertib has predictable PK and plasma levels at the RP2D that compare favorably with observe... | Authorship note: MDF and KJH are co–senior authors.
BACKGROUND
P hase 1 study of ATR i nhibition al o ne or with radiation t herapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia and Rad3-related) inhibitor ceralasertib (AZD6738) in advanced solid tumors.
METHODS
The primary obje... | Author contributions
Study conceptualization, design and protocol writing were by MTD, SAS, MDF and KJH. Study safety review was by KJH, UB, MPS, JS, and MDF. JG was the study manager and KM the statistician. PP and KES were responsible for genomic and PD assessments. IHC staining and analysis were supported by GNJ, SE... | We would like to thank The Breast Cancer Now histopathology core facility and the Institute of Cancer Research Genomics Facility. We acknowledge Magnus Hallin and Martine Roudier for pathology support and assistance with scoring IHC slides. We would like to thank Michael Hubank, Clinical Genomics at The Royal Marsden N... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e175369 | oa_package/b1/60/PMC10786692.tar.gz | |
PMC10786693 | 0 | Introduction
Childhood interstitial lung disease (chILD) is a heterogenous group of genetic lung disorders affecting infants and children who typically present with a range of symptoms and signs such as respiratory distress, hypoxemia, and diffuse pulmonary infiltrates ( 1 – 4 ). While many causal genes have been ident... | Methods
Patient iPSC derivation and maintenance.
All human iPSCs were maintained in feeder-free conditions, cultured on Matrigel-coated (Corning) plates in mTeSR media (StemCell Technologies), and passaged using Gentle Cell Dissociation Reagent (StemCell Technologies). Reprogramming of the BU3 human iPSC line was previ... | Results
E690K and W308R autosomal recessive ABCA3 mutations cause severe respiratory disease in newborns.
To develop an in vitro human model system able to study the downstream consequences of mutations in ABCA3 , we sought to generate iPSCs from individuals carrying rare homozygous ABCA3 mutations ( Figure 1 and ... | Discussion
Individuals carrying pathological variants of ABCA3 mainly present with either neonatal respiratory distress (NRDS) in full-term infants or chILD in children, or both. Incidentally, many patients with chILD do not present with NRDS, suggesting surfactant dysfunction alone in neonates is not the primary pat... | Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations ... | Author contributions
YLS, EEH, and DNK designed the project, performed experiments, and wrote the manuscript. HH performed the lipidomic analyses. PY performed Western blots. JAW and FSC provided patient tissue, clinical information, analyzed data, and edited the manuscript. CVM performed RNA-seq analyses. JK and AE pe... | This study was supported by NIH grants F30 HL142169 and TL1 TR001410, PCTC JumpStart Award U24HL134763 to YLS, R01 HL149853 to JAW, U01HL134745, U01HL134766, U01HL152976, and R01HL095993, to DNK, and a grant from the Novartis Institutes for Biomedical Research, Cambridge, MA to DNK. iPSC derivation and cell sharing was... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e164274 | oa_package/e8/7f/PMC10786693.tar.gz | |
PMC10786694 | 37988169 | Introduction
Neuronal inclusions consisting of the microtubule-associated protein tau are found in various neurodegenerative diseases known as tauopathies. Alzheimer’s disease (AD) is the most prevalent tauopathy and is characterized by the accumulation of extracellular β-amyloid (Aβ) plaques and intracellular misfolde... | Methods
Specific details on the research materials and portions of the experimental protocols can be found in the Supplemental Methods .
Animals.
Tau22 mice (B6. Cg-Tg(Thy1-MAPT)22Schd) express mutated human tau (G272V and P301S) associated with FTLD (1N4R tau) driven by a neuron-specific promoter (Thy1.2), and were m... | Results
Upregulation of microglial Gal3 in tauopathy.
To characterize the role of Gal3 in patients with tauopathy, we analyzed cortical and hippocampal samples from individuals with FTLD and AD ( Supplemental Table 1 ; supplemental material available online with this article; https://doi.org/10.1172/JCI165523DS1 ). As... | Discussion
Increasing evidence shows that pathological tau is transmitted and propagated between neurons ( 44 – 46 ). The secreted tau in its physiological state is dephosphorylated, while the pathological tau is phosphorylated and misfolded ( 47 , 48 ). Nonetheless, both pTau and nonphosphorylated tau have been found... | Alzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β-galactoside–binding protein that has been implicated in amyloid pathology. Its role in tauopathy remains enigmatic. Here, we showed that Gal3 w... | Author contributions
JJS designed, performed experiments, analyzed data and wrote the manuscript with the assistance of CWL, HLL, and TNAN. HMC bred and maintained animals used in the experiments. YMC, HTL, TMK, and SYC designed, performed, and analyzed scRNA-Seq. FLC and HCK maintained and provided iPSCs used in the e... | This research was supported by Academia Sinica and Ministry of Science and Technology, Taiwan [AS-GC-110-MDO5, AS-GC-110-05, MOST 107-2320-B-001 -013 -MY3]. The “Alzheimer & Tauopathie” laboratory is supported by programs d’investissements d’avenir LabEx (excellence laboratory) DISTALZ (Development of Innovative Strate... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e165523 | oa_package/c1/eb/PMC10786694.tar.gz | |
PMC10786695 | 37988162 | Introduction
One in six pregnancies is affected by some form of gestational diabetes (GD), a prevalence that is steadily rising in the context of the worldwide epidemics of obesity and early diabetic onset ( 1 ). Of these cases, 80% are classified as gestational diabetes mellitus (GDM), which present an episode of gluc... | Methods
Mice.
Wild-type C57BL/6J (B6.SJL-Ptprca, strain 000664), Pepcb/BoyJ (strain 002014), Ins2 Akita/J (strain 003548), Ager –/– (strain 032771), Apoe –/– (strain 002052), and Nlrp3 –/– (strain 021302; gift from R. Marsh, CCHMC) mice were purchased from The Jackson Laboratory. Depending on the experimental d... | Results
Two independent genetic and pharmacological models of diabetes in pregnancy.
We conducted our studies in 2 independent mouse models of diabetes in pregnancy. First, we used a mouse genetic model of type 1 diabetes ( Ins2 Akita/J ) under a rigorous breeding scheme ( Figure 1A ). C57BL/6-backcrossed Ins2 Akita/J... | Discussion
Our results demonstrate the existence of a hematopoietic memory associated with GD. It is tempting to speculate that this phenomenon is related to the hematopoietic memory recently established in the context of an immune response ( 31 ). Referred to as trained immunity, this concept proposes that the hematop... | Gestational diabetes is a common medical complication of pregnancy that is associated with adverse perinatal outcomes and an increased risk of metabolic diseases and atherosclerosis in adult offspring. The mechanisms responsible for this delayed pathological transmission remain unknown. In mouse models, we found that t... | Author contributions
VG performed and analyzed all the experiments with the help of SG, AA, and M Solomon. M Sakabe and NC performed all cardiac histopathology preparations, which were independently evaluated by AK. XZ and HLG provided expertise for ATAC-Seq analysis. AK and MX provided expertise and critical insights ... | This work was supported by NIH grants R01HL141418 and R01DK133145 (to DR), R01DK121062 (to HLG), and R01HL132211 and American Heart Association grant 23TPA1070041 (to MX). This work benefitted from funding from the Cooperative Center for Excellence in Hematology (award number U54DK126108). We acknowledge the assistance... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e169730 | oa_package/95/8b/PMC10786695.tar.gz | |
PMC10786696 | 37971879 | Introduction
Hematopoietic stem cell transplantation (HCT) is an essential and often the sole curative treatment strategy for high risk hematologic malignancies ( 1 ). Graft-versus-host disease (GVHD), the foremost complication of allogeneic HCT, is a major limitation of this procedure, accounting for deleterious effec... | Methods
Methylation analysis.
We prepared cfDNA and measured its concentration (in nanograms per milliliter plasma), then treated with bisulfite to expose the status of methylation and performed multiplex PCR as described ( 36 ) to amplify marker loci. PCR products were sequenced on a NextSeq machine (Illumina), and th... | Results
DNA methylation markers for targeted assessment of cGVHD-relevant tissue damage.
We compared publicly available methylomes of specific human tissues ( 21 ) and identified genomic loci containing CpG sites that are uniquely unmethylated in specific tissues or cell types, relevant to cGVHD. These included hepatoc... | Discussion
Our study shows that tissue-specific DNA methylation patterns can serve as plasma biomarkers for detection of tissue turnover in cGVHD. We demonstrated a general elevation in cfDNA concentration in patients with cGVHD, and an elevation of cfDNA from specific organs as well as immune and inflammatory cells. C... | Authorship note: BA and DN are co–first authors.
BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue tu... | Author contributions
BA, BG, SJS, RS, and YD designed the research study. BA, DN, OGR, SG, IFF, and SP conducted experiments. BA, ES, OGR, IA, BG, SJS, RS, YD, and JM analyzed data. BA, SG, MK, AF, PS, TZ, and ALS provided reagents. BA, ES, IA, BG, RS, YD, and JM wrote the manuscript. BA and DN are co–first authors. Th... | This work was supported by grants from Israel Innovation authority (to YD and BA), the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine, The Israel Science Foundation, the Waldholtz/Pakula family, the Robert M. and Marilyn Sternberg Family Charitable Foundation, and the Helmsley Charitable T... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e163541 | oa_package/dd/32/PMC10786696.tar.gz | |
PMC10786697 | 0 | Conclusions and future directions
The analysis in this Review indicates that metabolic reprograming is a reasonable strategy for enhancing antitumor immunity in TME. In a general sense, characterization of the immune component of the TME could be considered when deciding the metabolic approaches to alter the TME and co... | Immunometabolism is a burgeoning field of research that investigates how immune cells harness nutrients to drive their growth and functions. Myeloid cells play a pivotal role in tumor biology, yet their metabolic influence on tumor growth and antitumor immune responses remains inadequately understood. This Review explo... | Therapeutic potential of targeting macrophage metabolism in cancer
Immunometabolism is a rapidly growing area of study that explores how immune cells employ various nutrients to support their growth and functionality. The metabolic programming of immune cells has wide-ranging effects on different disease processes, and... | 01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e175445 | oa_package/21/03/PMC10786697.tar.gz | ||||
PMC10786698 | 37962965 | Introduction
Adolescent idiopathic scoliosis (AIS) is a condition in which the spine is deformed with a lateral curvature exceeding 10 degrees in otherwise healthy adolescents ( 1 , 2 ). With a prevalence of 0.47% to 5.2% in adolescents worldwide, AIS is the most common pediatric skeletal disorder and usually worsens ... | Methods
Study participants.
Subjects diagnosed with AIS were recruited from the DKCH, PUMCH, and SRC. Diagnosis was made by standing whole-spine radiographs. Eligible subjects were patients diagnosed with scoliosis (Cobb angle ≥10°) without manifestation of any congenital or neuromuscular defect at the time of recruitm... | Results
Identification of SLC6A9 variants in AIS patients.
We performed a genetic analysis to identify pathogenic variants in a multicenter AIS cohort consisting of multigeneration families, trios, and approximately 1,700 sporadic patients. We first conducted whole-genome sequencing (WGS) on 10 individuals in family 1 ... | Discussion
Our work explores the genetic basis and pathogenic mechanisms that lead to the development of idiopathic scoliosis in adolescents. By inheritance mapping in 2 large families with dominant inheritance of AIS, we identified an AIS locus on chromosome 1p34.1 and the causal gene SLC6A9 . We further identified a... | Authorship note: Xiaolu Wang, MY, and JPYC are co–first authors. JPYC, YQS, and BG contributed equally to this work and are co–corresponding authors.
Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopath... | Author contributions
JPYC, YQS, and BG conceived the project. JPYC, PWHC, JJR, WT, GQ, ZW, TJZ, SI, NW, CAW, and KDKL recruited patients. Xiaolu Wang, MY, JPYC, and PWHC curated data. Xiaolu Wang, MY, YF, MW, Xiaojun Wang, SZ, AMK, ZC, Xiwei Wang, and YH developed methodology. Xiaolu Wang, MY, YF, MW, Xiaojun Wang, SZ,... | We thank all patients and their family members for participating in this study; Wing Ki Cheung of the Department of Orthopaedics and Traumatology, University of Hong Kong for assistance with sEMG testing; and Miao Chen and Jing Guo, University of Hong Kong, for assistance with confocal microscopy. The authors acknowled... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e168783 | oa_package/64/bc/PMC10786698.tar.gz | |
PMC10786699 | 0 | Introduction
Bladder cancer is the sixth most common cancer in the United States, with an estimated 82,290 new cases and an estimated 16,710 deaths in 2023 ( 1 ). At diagnosis, approximately 75% of bladder cancers are non–muscle-invasive (NMIBC), while 25% are de novo muscle-invasive (MIBC) ( 2 ). The initial treatment... | Methods
Generation of ColA1-LSL-FGFR3 S249C mouse.
We generated a mouse allele with Cre-inducible expression of human FGFR3 cDNA encoding the S249C hotspot mutation knocked into the Col1a1 locus. The human FGFR3 S249C cDNA coding region with the Kozak sequence (GCCGCCACC) was introduced into vector pGV at the E... | Results
UPFL mice develop papillary, high-grade NMIBCs.
To understand the role of FGFR3 in bladder cancer biology, we knocked in the cDNA of human FGFR3 encoding the S249C mutation under control of a LoxP-Stop-LoxP cassette into the collagen type 1, α1 ( Col1a1 ) locus to generate mice harboring the Col1a1 -LSL- FGF... | Discussion
Herein, we present a mouse model of FGFR3 S249C -driven UC that when combined with the Trp53 R270H mutation results in high-grade NMIBC. The FGFR3-driven murine bladder tumors reflect their counterparts found in human UC. For example, RNA expression analysis of our UPFL tumors classify them in the conse... | Authorship note: AO and TU contributed equally to this work.
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the bladder, in which FGFR... | Author contributions
AO, TU, MR, JSD, KKW, and WYK conceived and planned the study. AO, TU, MR, XZ, MZ, LDP, TC, YK, DW, HH, HL, ASG, JDR, UM, AC, FS, JS, SEW, JSD, and SCG generated, analyzed, and interpreted the data. JSS generated, analyzed, and interpreted data and wrote and reviewed the manuscript. AO, TU, MR, TLR... | We thank Bently Midkiff and Lauren Ralph in the Pathology Services Core (PSC) for expert technical assistance with histopathology/digital pathology, including tissue sectioning, IHC staining, and imaging. The PSC is supported in part by a National Cancer Institute (NCI) Center Core Support Grant (P30CA016086). Addition... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e169241 | oa_package/f9/ab/PMC10786699.tar.gz | |
PMC10786700 | 37962961 | Introduction
Diarrhea remains an important cause of global mortality, and diarrheal illness accounts for more than 25% of deaths in children under 5 years of age in sub-Saharan Africa and South Asia ( 1 – 3 ). Secretory diarrhea, a major form of diarrhea with diverse etiologies, leads to the activation of prosecretory ... | Methods
Cell culture.
T84 cells (ATCC CCL–248, human colon carcinoma cells) were cultured as previously described ( 18 , 29 ) on inserts (12 mm diameter, 0.4 μm pore size; Corning Life Sciences) and used for I sc experiments 7 days after plating. FRT cells stably expressing human WT CFTR (FRT-CFTR cells) were culture... | Results
Extracellular Ca 2+ has minimal effect on CFTR-mediated Cl – secretion in T84 cells.
To test the effect of extracellular Ca 2+ on Cl – secretion, short-circuit current (I sc ) measurements were done in human colonic T84 cells bathed with varying concentrations of Ca 2+ . Changing the extracellular Ca 2+ co... | Discussion
Here, we showed that CFTR-mediated Cl – secretion in human intestinal epithelial cells and mouse intestine was dependent on extracellular Mg 2+ concentration, which exerted its effect through CaSR activation (see Figure 9 for the proposed mechanisms). Interestingly, Ca 2+ , which is considered the main p... | Authorship note: LDSG and TC are co–first authors and contributed equally to this work.
Cholera is a global health problem with no targeted therapies. The Ca 2+ -sensing receptor (CaSR) is a regulator of intestinal ion transport and a therapeutic target for diarrhea, and Ca 2+ is considered its main agonist. We found... | Author contributions
OC made the original discovery, conceptualized the study, and designed the experiments; LDSG, TC, RM, PDC, QG, and OC performed the experiments. LDSG, TC, and OC analyzed the data. OC obtained funding, supervised the study, and wrote the manuscript. LDSG and OC revised the manuscript. All authors r... | This study was supported by grants from the NIH (DK126070 and DK072517) and the Cystic Fibrosis Foundation.
11/14/2023
In-Press Preview
01/16/2024
Electronic publication | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e171249 | oa_package/08/f8/PMC10786700.tar.gz | |
PMC10786701 | 38015629 | Introduction
Aging introduces a series of complex molecular, structural, and functional changes to blood vessels, with important consequences for organ physiology ( 1 ). In the brain, compromised vascular function can trigger a spectrum of pathologies, ranging from acute incidents like strokes to enduring and incapacit... | Methods
Mice
B6;129S1- Notch3 tm1 Grid/J ( Notch3 –/– ) (JAX:010547) and C57BL/6J (JAX:000664) mice were purchased from The Jackson Laboratory. Animals were housed at UCLA, Northwestern Medicine, and National Heart, Lung, and Blood Institute facilities.
Human brain tissue
Formalin-fixed frontal lobe sections were acqui... | Results
Single-cell transcriptomics reveals Notch3 decline as a molecular readout of vascular aging.
To evaluate the cellular changes associated with vascular aging, we examined central retinal arteries of mice from 1 month to 24 months of age ( Figure 1, A and B ). The reason to use the retina relates to the stereotyp... | Discussion
Here, we used single-cell transcriptomics to identify age-associated molecular changes in brain vessels and found that Notch3 and Jagged1 were drastically decreased in aging, implying age-dependent reductions in Notch signaling. Indeed, we verified such reductions in human brain vessels at the protein level.... | Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked dec... | Author contributions
MCR designed and performed experiments and wrote and edited the manuscript. FM performed bioinformatics analysis. RHK, AM, GEH, JS, SM, AB, DPS, DP, SB, EK, AS, JW, and CH performed experiments. KM coordinated patient sample distribution. AMS provided human patient samples and supervised experiment... | We thank the UCLA Broad Stem Cell Research Center for sequencing scRNA-Seq libraries and the Mouse Histology and Phenotyping Core and the Small Animal Imaging Facility at Northwestern University. A special thanks to Michelle Steel for assistance with husbandry and mouse experimentation. This work was supported by NIH g... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e166134 | oa_package/22/30/PMC10786701.tar.gz | |
PMC10786702 | 38015640 | Introduction
Glycogen storage disease type III (GSDIII) is a rare inborn error of metabolism, with an incidence of 1 in 100,000, caused by mutations in the AGL gene, which encodes for the glycogen debranching enzyme (GDE; also known as amylo-α-1,6-glucosidase) ( 1 , 2 ). GDE acts along with glycogen phosphorylase to... | Methods
In vivo studies.
The Agl knock-out mice ( Agl –/– , Agl tm1b(EUCOMM)Wtsi ) were previously described ( 15 ) and are of mixed background (C57BL/6J and Balb/c). The Agl knock-out rats ( Agl –/– ) were recently generated using the CRISPR tool and are of Sprague Dawley background. rAAV vectors encoding human G... | Results
Generation of a single-vector approach for GSDIII based on a functional, truncated GDE.
Our team previously demonstrated the possibility to correct the muscle and heart phenotype of a GSDIII mouse model ( Agl –/– mice) using a dual vector approach harboring the cytomegalovirus (CMV) promoter ( 15 ). A GDE expr... | Discussion
In GSDIII, inactivating mutations on the AGL gene result in the absence of a functional GDE and accumulation of limit dextrin in liver, heart, and skeletal muscles. The hepatic and metabolic phenotypes (hepatomegaly and hypoglycemia) appear early, in patients of around 1 year of age ( 2 ). Moreover, recent... | Authorship note: AG and JR contributed equally to this work.
Glycogen storage disease type III (GSDIII) is a rare inborn error of metabolism affecting liver, skeletal muscle, and heart due to mutations of the AGL gene encoding for the glycogen debranching enzyme (GDE). No curative treatment exists for GSDIII. The 4.... | Author contributions
AG, JR, VMR, LR, PV, RL, MV, YKB, TLB, JC, JN, LJ, RF, LVW, JE, IA, and LH were involved in data generation. BB and GD were involved in rAAV production and purification. ND, XN, and GR supervised the experimental activities. AG, JR and, GR wrote the manuscript, and all authors provided review and e... | This work was supported by Genethon, the “Association Française contre la Myopathie,” the “Association Francophone des Glycogénoses,” and the National Research Agency (ANR-17-CE18-0014 to GR and ANR 22 CE17 0031 to LH). AG is recipient of a “Poste d’Accueil Inserm” doctoral fellowship from the French National Institu... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e172018 | oa_package/6f/03/PMC10786702.tar.gz | |
PMC10786703 | 37943617 | Introduction
ER-associated degradation (ERAD) is the key cellular quality-control mechanism underlying the clearance of misfolded proteins from the ER, thereby generating a conducive environment for protein folding, maturation, and maintaining ER homeostasis. The suppressor of lin-12-like–HMG-CoA reductase degradation ... | Methods
Human subjects.
The patient cases were gathered through the web-based tool GeneMatcher ( 48 ) ( https://genematcher.org/statistics/ ). We present 5 developmentally delayed children with agammaglobulinemia. They were raised from birth in a big family of Roma population living in an isolated region in the souther... | Results
Identification of a biallelic SEL1L C141Y variant in humans.
Five siblings from 2 consanguineous families in a large Slovakian family presented with developmental delay, neurological disorders, and agammaglobulinemia in childhood ( Figure 1 ) and were suspected of inherited genetic disorder. Array comparative ... | Discussion
Here we report a group of patients expressing a new biallelic SEL1L C141Y variant with clinical features of ENDI-A ( Figure 8A ). They resemble the ENDI patients described in the accompanying paper ( 32 ) in terms of neurodevelopmental disorders characterized by infantile-onset developmental delay, intelle... | Authorship note: DW, LLL, and HHW contributed equally to this work. RGF, JAM, and LQ are co–senior authors.
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-associated degradation (ERAD) plays a critical role in many physiological processes in mice, including immunity, water homeostasis, and e... | Author contributions
DW, HMW, ALP, SW, KS,GH, AS, LD, and JAM obtained clinical, molecular, and biochemical data. LLL, HHW, ZJL, ZW, XW, and TTY designed and performed biochemical experiments. KK and RGF assisted with some experiments and analysis. PC acquired clinical and immune profile data. DW, RGF, JAM, and LQ dire... | We are deeply grateful for all patients and their families for their consent and willingness to participate in this study. We thank members in the Qi, Mayr, Wolf, Ciznar, Danisovic, Soltysova, Skalicka, and Weis laboratories for technical assistance and insightful discussions; Shengyi Sun, Fowzan S. Alkuraya, Nicola Br... | CC BY | no | 2024-01-16 23:40:17 | J Clin Invest.; 134(2):e170882 | oa_package/43/e7/PMC10786703.tar.gz | |
PMC10788183 | 38226110 | Introduction
Liver surgery is a primary treatment modality for hepatocellular carcinoma (HCC) and colorectal liver metastasis, markedly reducing mortality and morbidity over the last decade [ 1 - 4 ]. Advances in diagnostic imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) have led to earlie... | Materials and methods
Trial design and participants
This exploratory prospective study included patients between August 2017 and March 2020 based on the criteria shown in Table 1 . Patients were excluded according to the criteria shown in Table 2 .
Patient data were collected from one month before marking to one mont... | Results
A total of 19 patients with liver tumors measuring ≤20 mm and requiring resection were treated between August 2017 and March 2020 (Figure 1 ). Of these patients, nine (47.3%) had primary liver cancer, whereas 10 (52.7%) had metastatic tumors. Percutaneous marking was performed in six patients, all of whom had ... | Discussion
Small liver nodules are difficult to distinguish intraoperatively. Tumors that cannot be identified by ultrasonography are challenging to treat locally, with procedures such as radiofrequency ablation; and when resection is performed, it can only be conducted in approximation based on anatomic landmarks. Thi... | Conclusions
This study demonstrated the safety and feasibility of preoperative marking for small liver tumors. Preoperative marking for the intraoperative identification of liver tumors does not have any adverse effects and enables surgical navigation, making it a safe and effective modality. These findings provide a b... | Background
Small tumors in liver cirrhosis are difficult to distinguish using intraoperative ultrasonography. In addition, preoperative chemotherapy for metastatic liver cancer may diminish tumor size, thus making tumors difficult to identify intraoperatively. To address such difficulties, we devised a method to mark l... | The authors thank Editage (www.editage.jp) for English language editing. | CC BY | no | 2024-01-16 23:40:17 | Cureus.; 15(12):e50603 | oa_package/db/96/PMC10788183.tar.gz | |
PMC10788185 | 38226314 | Introduction
In 1906, carotene, lutein and chlorophyll were successfully isolated from green leaves [1] . Carotenoids are isoprene metabolites derived from isoprene pyrophosphate (IPP) and its isomer, dimethylallyl diphosphate (DMAPP) [2] . The carotenoid synthesis pathway involves nine catalytic enzymes, including o... | Materials and methods
Experimental materials
12 materials were chosen to determination of the lutein content in cotton seedlings ( Table 1 ), with 30 capsules per material and three replicates. PEG6000 (Solarbio,Beijing) served as the standard for simulating drought conditions [19] . The treatment concentration was se... | Results and analysis
Germination test and PEG tolerance evaluation of 12 cotton germplasm
Existing studies have shown that lutein is closely related to stress resistance. As shown in Table 1 , the content of Zhong H177 lutein in 12 materials was high, and the germination potential, fresh weight root length were also a... | Discussion
Abiotic stress significantly impacts on the productivity of cotton. Lutein, known for its ability to remove ROS, plays a crucial role in plants' response to abiotic stress. The identification of LCYs, key genes in the biosynthetic pathway of lutein, is of great significance for improving the stress tolerance... | Conclusion
In this research, aimed at unraveling the regulatory role of lutein in enhancing cotton's drought resistance, conducted a comprehensive evaluation of LCYs gene structure, phylogeny, and expression patterns. Fluorescence quantitative experiments showed that GhLCYs genes responded to various abiotic stresses, ... | These authors contributed equally to this work.
Drought stress significantly affects crop productivity. Carotenoids are essential photosynthetic pigment for plants, bacteria, and algae, with signaling and antioxidant functions. Lutein is a crucial branch product in the carotenoid synthesis pathway, which effectively im... | Ethics approval and consent to participate
Not applicable.
Consent to publication
All authors consent this version for publication.
Funding
This work was supported by The 10.13039/501100012166 National Key Research and Development Program of China (2023YFD1200300).
CRediT authorship contribution statement
YW conceive... | Supplementary material
.
.
.
Data Availability
The datasets generated and/or analyzed during the current study are available in the CottonFGD ( https://cottonfgd.org/ ). Additional: Supplementary Table S1 . | CC BY | no | 2024-01-16 23:40:17 | Comput Struct Biotechnol J. 2023 Dec 22; 23:384-395 | oa_package/b2/f0/PMC10788185.tar.gz |
PMC10788186 | 38225983 | Introduction
Patients with acute ischemic stroke can receive intravenous thrombolysis up to 4.5 h after symptom onset ( 1 ). However, up to 25% of all stroke patients have an unknown time of symptom onset because stroke occurs while sleeping or the time of onset cannot be communicated due to aphasia or a disturbed leve... | Methods
Study design and patients
This analysis of the retrospective multicenter MissPerfeCT observational cohort study (08/2009–11/2017) ( 7 ) includes consecutive patients with known onset of symptoms from seven tertiary stroke centers who were clinically diagnosed with acute ischemic stroke and received multimodal C... | Results
Patient baseline characteristics
A total of 247 patients were included in our study, of whom 219 (88.7%) were suitable for thrombolysis and 28 (11.3%) were not suitable for thrombolysis (comprising patients with an onset <4.5 h and those with an onset >4.5 h fulfilling automated mismatch criteria). The median t... | Discussion
This multicenter study shows that the assessment of hypoperfusion-hypodensity mismatch identifies patients who are eligible for thrombolysis with higher sensitivity (89.0%) compared with automated perfusion analysis (50.2%) and might thus increase the number of patients treated with thrombolysis among those ... | Conclusion
Eligibility for thrombolysis among stroke patients with unknown time of symptom onset can be determined by the detection of a hypoperfusion-hypodensity mismatch with higher sensitivity compared to automated perfusion mismatch quantification, the gold standard that was established in a randomized trial.
Thus,... | Edited by: Wen-Jun Tu, Chinese Academy of Medical Sciences and Peking Union Medical College, China
Reviewed by: Gabriel Broocks, University of Hamburg, Germany; Jin Lv, Pla Rocket Force Characteristic Medical Center, China
† These authors have contributed equally to this work and share first authorship
‡ These authors ... | Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics statement
The studies involving humans were approved by Ethikkommission der Ärztekammer Westfalen Lippe (reference number: 2017-233-f-S). The studies were conduct... | Conflict of interest
JM has received grants from Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung (BMBF), Else KrönerFresenius-Stiftung, EVER Pharma Jena GmbH, and Ferrer International, travel grants from Boehringer Ingelheim, and speaking fees from Bayer Vital and Chugai Pharma. MD has re... | CC BY | no | 2024-01-16 23:40:17 | Front Neurol. 2023 Dec 29; 14:1320620 | oa_package/e8/02/PMC10788186.tar.gz |
PMC10788187 | 38220147 | Background
Extreme weather and climate change continue to cause concern among researchers worldwide, and the increase in the frequency and intensity of extreme weather events poses a threat to human health [ 1 – 3 ]. Numerous studies in the past have confirmed the adverse effects of extreme temperatures on human health... | Methods
Study area
The Sichuan Basin, located in southwest China, is one of the four major basins in China. The climate of the basin belongs to the humid sub-tropical monsoon type, with high temperatures in the east and low temperatures in the north and west. In addition, it is one of the most populous regions in China... | Results
Table 1 shows descriptive data for total non-accidental deaths, mean temperature, minimum temperature, maximum temperature, mean relative humidity, and air pollutants for four cities in the Sichuan Basin during the study period. The total number of deaths recorded in the four cities was 751,930. The total num... | Discussion
Our study assessed the associations between low and high temperatures and non-accidental mortality using more than 0.7 million deaths from four cities in the Sichuan Basin of southwest China, and we further estimated the mortality burden attributable to heat and cold. The results showed that both heat and co... | Conclusions
Our study indicates that a significant association between non-optimal temperature and non-accidental mortality. Most temperature-related deaths were caused by low temperatures, with moderately high and low temperatures representing the majority of the mortality burden. Those under 65 years old, females, an... | Yizhang Xia, Chunli Shi and Yang Li made the same contributions to this manuscriptspondence
Background
There are few multi-city studies on the association between temperature and mortality in basin climates. This study was based on the Sichuan Basin in southwest China to assess the association of basin temperature with... | Abbreviations
particulate matter <2.5 μm in aerodynamic diameter
daily 8-hour mean concentrations of ozone
relative humidity
minimum mortality temperature
minimum mortality percentile
attributable fractions
distributed-lag non-linear models
standard deviation
relative risk
confidence interval
Supplementary information
... | CC BY | no | 2024-01-16 23:40:17 | Environ Health Prev Med.; 29:1 | oa_package/90/71/PMC10788187.tar.gz | |
PMC10788188 | 38226039 | Background
Pistacia chinensis and weinmannifolia have long been used as important medicinal plants and are considered the best potential resources for developing new natural products for pharmaceutical purposes. However, genomic and genetic information are very limited for P. chinensis and not yet available for P... | Experimental Design, Materials and Methods
Sample collection
Fresh leaves were collected from fully-grown P. chinensis and P. weinmannifolia in June 2015 at Yunnan, China. Leaf samples were submerged into liquid nitrogen, transferred into RNAlater solution for long-term transportation (Ambion Ins, USA), and then st... | Pistacia chinensis and Pistacia weinmannifolia are small trees and are distributed in East Asia, in particular China. The data on P. chinensis presented in this article is associated with the research article, “DOI: 10.5010/JPB.2019.46.4.274 ” [1] . Both P. chinensis and P. weinmannifolia have long been used... | Specifications Table
Value of the Data
• The data provides transcripts as the first transcriptome reference for P. weinmmanifolia , and as for P. chinensis it will enrich genomic information since only a couple of transcriptome analyses have been reported. • These data will be useful for studying genes differentia... | Data Availability
Transcriptome sequecing of two Pistacia species (Original data) (NCBI Bioproject)
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledg... | CC BY | no | 2024-01-16 23:40:17 | Data Brief. 2023 Dec 22; 52:110002 | oa_package/1e/49/PMC10788188.tar.gz | |||
PMC10788189 | 38226037 | Background
Biochar and wood vinegar production using the pyrolysis process has become popular due to the usefulness of the product for various applications, particularly in the agricultural sector. However, a design is needed that is applicable for smallholder farmers, and a study is required to characterise the data a... | Experimental Design, Materials and Methods
Pyrolyser design and development
The pyrolysis system used in this study comprised a two-stage production chamber with 10 kg of capacity for the initial raw materials ( Fig. 1 , Fig. 2 , Fig. 3 , Fig. 4 ). The main chamber produced biochar, while the second chamber, also kn... | Biochar production is an effective approach to managing abundant agricultural wastes. Pruning wastes from trimming the branches of trees such as carambola and mango, as well as coconut shells, are among the agricultural wastes that have reutilisation potential, which would simultaneously reduce the space required for d... | Specifications Table
Value of The Data
• The data describe the characteristics of biochar produced from coconut shells, carambola pruning, and mango pruning using low-temperature slow pyrolysis with an upward pyrolysation process. • Upward pyrolysation with self-heating is a common technique for producing biochar, es... | Data Availability
Design of a pyrolysis system and the characteristics of biochar produced from selected agricultural wastes (Original data) (Mendeley Data)
Acknowledgements
The authors would like to thank Mr Mohd Firdaus A.Wahab @ Othman, Mr Mohd Ghazali Rusli, Mr Mohamad Shahir Supian, and Mr Ashraaf Siddiqi for... | CC BY | no | 2024-01-16 23:40:17 | Data Brief. 2023 Dec 21; 52:109997 | oa_package/e1/b7/PMC10788189.tar.gz | |||
PMC10788192 | 38226029 | Experimental Design, Materials and Methods
Questionnaire Structure
• The data were collected using an anonymously administered questionnaire. • The questions were designed to be simple and unambiguous, such as ‘How old are you (years)?’ or ‘What Nigerian ethnic group do you belong to?’ • The questionnaire had three q... | Gender equity, particularly in healthcare, has been gaining increasing attention in recent years. The goal is to ensure that everyone has equal access to quality healthcare services irrespective of age, gender, or socio-economic status. However, most countries in sub-Saharan Africa struggle to meet this goal, due to se... | Specifications Table
Value of the Data
• This data is useful for assessing gender-based healthcare accessibility in northern Nigeria, a region where gender discrimination is prevalent. • Data analysis can be carried out on the data to assess the impact of various socio-economic factors, such as marital status, level ... | Data Availability
Data on Gender-Equitable Healthcare Accessibility in Northern Nigeria (Original data) (Mendeley Data).
Acknowledgments
This work was supported by USAID and DAI Global - “Nivi and the University of Lagos (UNILAG): Partnering to Create a Gender-Aware Auditing Tool.”
Declaration of Competing Interes... | CC BY | no | 2024-01-16 23:40:17 | Data Brief. 2023 Dec 18; 52:109979 | oa_package/9d/ac/PMC10788192.tar.gz | ||||
PMC10788193 | 38226161 | Introduction
There is growing interest in the use of aquatic eDNA for studying population genetics of focal species. 1 , 2 , 3 To date much of this research has focused on variation in target regions of the mitochondrial genome, and it has been possible to resolve spatial genetic structure in a range of vertebrate spe... | STAR★Methods
Key resources table
Resource availability
Lead contact
Further information and requests for resources should be directed to and will be fulfilled by the lead contact, Martin Genner ( m.genner@bristol.ac.uk ).
Materials availability
The study did not generate new unique reagents.
Data and code availabil... | Results
Our study system is Lake Masoko, a crater (maar) lake in southern Tanzania that has no surface connections with nearby rivers 13 , 14 ( Figures 1 A and 1B). The lake is ∼700 m in diameter, has a maximum depth of ∼35 m with rapid attenuation of light with increasing depth ( Figure 1 E). The lake exhibits season... | Discussion
Our study demonstrates that the clear depth differences in genetic structure of the Lake Masoko A. calliptera ecomorphs are reflected in eDNA present in their immediate environment. This pattern is not consistent with complete homogenization of DNA in the water column, although we consider it plausible tha... | Lead contact
Summary
There is considerable potential for nuclear genomic material in environmental DNA (eDNA) to inform us of population genetic structure within aquatic species. We tested if nuclear allelic composition data sourced from eDNA can resolve fine scale spatial genetic structure of the cichlid fish Astatot... | Supplemental information
Acknowledgments
We thank staff of the Tanzania Fisheries Research Institute for support during fieldwork. We thank the researchers who contributed to the collection of fish and generation and analysis of whole genome data from Lake Masoko Astatotilapia calliptera , including Emília ... | CC BY | no | 2024-01-16 23:40:17 | iScience. 2023 Dec 7; 27(1):108669 | oa_package/86/87/PMC10788193.tar.gz | ||
PMC10788196 | 38226031 | Background
In the context of Bangladesh, there exists a pressing requirement to ascertain sweet potato genotypes that exhibit the high yield potential and demonstrate stability in varying environmental conditions. The original article highlights the yield potential and correlation of traits of the examined varieties. N... | Experimental Design, Materials and Methods
Description of the study area
The study took place in the 2021–22 growing season across five districts in Bangladesh: Gazipur, Bogura, Jamalpur, Chattogram, and Jashore. The research sites are located in Bangladesh, spanning latitudes 23.6850° N and longitudes 90.3563° E, cove... | A study was conducted in five regions of Bangladesh, specifically Gazipur, Bogura, Jamalpur, Jashore, and Chattogram, each characterized by suitable agro-ecologies for sweet potato cultivation. The purpose of this data article was to demonstrate the correlations between traits and the selection of stable varieties base... | Specifications Table
Value of the Data
• This dataset presents information on the relationship between sweet potato traits and their impact on storage root yield. • The dataset in this article supplies data to researchers, farmers, and industry users on the multi trait stability of sweet potato genotypes grown in dif... | Supplementary materials
Data Availability
Multi trait stability indexing and trait correlation from a dataset of sweet potato (Ipomoea batatas L.) (Original data) (Mendeley Data)
Acknowledgements
The authors are thankful to Bangladesh Agricultural Research Institute for providing planting materials for the stu... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 21; 52:109995 | oa_package/56/4d/PMC10788196.tar.gz | |||
PMC10788197 | 38226040 | Experimental Design, Materials and Methods
Location
The data collection was conducted on two different locations. The first location is a freshwater fish farm in Tasikmalaya Region, West Java Indonesia (7°20′53.6"S 108°11′14.2"E). The second location is a large open-air fishpond in a food court area in Bandung City, We... | This dataset is part of fundamental research to produce IoT monitoring in fishponds. The data consists of the results of measurements of pH, total dissolved solids (TDS), and water temperature obtained through manual sensor devices in several locations at different times. Additionally, this data also includes images ta... | Specifications Table
Value of the Data
• The dataset contains information on fishpond conditions, visually and numerically. The data are useful in investigation on method to determine fishpond water quality through visual means. • Researchers may benefit from this dataset through the dataset's linkage on visual data ... | Data Availability
Fishpond Visual Condition Dataset v2.0 (Original data) (Mendeley Data)
Acknowledgements
This work is supported and funded by the Ministry of Education, Culture, Research, and Technology Republic of Indonesia through Fundamental Research Grant Program with contract number: 179/E5/PG.02.00.PL/202... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 23; 52:110009 | oa_package/ec/92/PMC10788197.tar.gz | ||||
PMC10788198 | 38226156 | Introduction
The prevalence of CRPC continues to be the leading cause of mortality among male patients worldwide. 1 , 2 The rapid progression, ease of transfer, and development of late castration resistance of CRPC pose challenges to treatment. 3 , 4 The existence of androgen-repressed genes has been reported in a fe... | STAR★Methods
Key resources table
Resource availability
Lead contact
Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Ning Jiang ( jiangning@tmu.edu.cn ).
Materials availability
The plasmids used in this study are available from the lead co... | Results
TNIK was upregulated in castration-resistant prostate cancer
Previously, LNCaP cells were cultured under androgen deprivation conditions using 10% Certified FBS Charcoal Stripped and RPMI Medium 1640 culture medium. After about four months of culture and multiple passages, the CR-LNCaP cell line was obtained. S... | Discussion
In the present study, we have elucidated crucial components of the interplay between the AR and EGFR signaling pathways via TNIK. By selectively inhibiting TNIK to impede EGFR phosphorylation, we effectively suppressed the proliferation of CRPC.
The previous study reported that TNIK was frequently upregulate... | These authors contributed equally
Lead contact
Summary
The development of castration-resistant prostate cancer (CRPC) is driven by intricate genetic and epigenetic mechanisms. Traf2- and Nck-interacting kinase (TNIK) has been reported as a serine/threonine kinase associated with tumor cell proliferation or unfavorable ... | Supplemental information
Acknowledgments
We thank Hans Clevers, Professor of Hubrecht Institute, for kind assistance with TNIK vectors. This work was supported by grants from the 10.13039/501100001809 National Natural Science Foundation of China (81872079, 81572538) and the Science Foundation of Tianjin (No.:... | CC BY | no | 2024-01-16 23:40:18 | iScience. 2023 Dec 12; 27(1):108713 | oa_package/b3/48/PMC10788198.tar.gz | ||
PMC10788203 | 38226041 | Background
The obtained data serves as a comparison material with other case data for the projection of the Indonesian Presidential election in 2024. For example, The obtained data could be compared with the results of obtained data during the determination of presidential candidates and throughout the campaign period,... | Experimental Design, Materials and Methods
Data collection, labeling & preprocessing
Data collection was conducted in April 2023 using the Twitter API. Before collecting data, users must have a developer account. The obtained data is in CSV and Excel formats. The original data is stored in the available repository (Fol... | Discussion
The data available in the repository is dehydrated by removing the attribute column for the username. This is intended to follow the ethics available on the Twitter platform. In addition to the deletion of the username attribute column, the data available in the repository is no longer deleted because it is ... | Indonesia is one of the countries that is currently entering the political year for the election of President, Regional Heads, and Members of the Legislative in 2024. This has become a hot topic on social media, especially about the Presidential Election. Twitter is one of the platforms with the largest users in Indone... | Specifications Table
Value of the Data
• This dataset is useful for policymakers, pollsters, political and government academics, candidates and winning teams, and political parties. • This dataset provides insight into the fact that the Indonesian's involvement in freedom of speech on social media platforms over po... | Data Availability
Indonesia Presidential Candidate's Dataset, 2024 (Original data) (Mendeley Data)
Acknowledgements
This work was supported by the Indonesian Ministry of Education, Culture, Research, and Technology under Contract Number 0557/E5.5/AL.04/2023. The author also gratefully for the cooperation as a pa... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 19; 52:109993 | oa_package/35/e8/PMC10788203.tar.gz | ||
PMC10788206 | 38226042 | Experimental Design, Materials and Methods
Field data collection
The datasets were collected from small and medium-scale farms in significant coffee and cashew growing regions of Uganda, including in the southern, central, eastern, and northern parts of the country. However, most of the coffee images were collected fro... | Conventional methods of crop yield estimation are costly, inefficient, and prone to error resulting in poor yield estimates. This affects the ability of farmers to appropriately plan and manage their crop production pipelines and market processes. There is therefore a need to develop automated methods of crop yield est... | Specifications Table
Value of the Data
• Flowering intensity estimation. Flowering represents an important stage in coffee and cashew farming since it affects crop yield. It has a significant impact on yield in that flowering intensity is positively correlated with the amount of crop yield. Therefore, flowering inten... | Data Availability
Coffee and Cashew Nut Dataset (Original data) (Mendeley Data)
Acknowledgements
We would like to thank Dr. Sammy Olal from the National Coffee Research Institute and Mr. Joseph Okilan for their support in the collection and curation of these datasets. The work is funded by a sub-grant from Lacuna... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 14; 52:109952 | oa_package/af/3d/PMC10788206.tar.gz | ||||
PMC10788208 | 0 | Introduction
Knee arthroplasty alleviates pain and restores function for nearly 900,000 Americans every year, and by 2030, this number is expected to more than double because the aging population desires to remain active [ 1 ]. As the number of expected primary knee arthroplasties continues to grow, so will revision pr... | Material and methods
Institutional review board approval was obtained prior to the initiation of this study. A total of 25 consecutive cases by 2 fellowship-trained arthroplasty surgeons at a single intuition from July 2021 through March 2023 were reviewed. All subjects had undergone a prior TKA using conventional jig-... | Results
Statistical determinations
There were statistically significant differences between the placement of the RRI and the PI. The overall repeated-measures ANOVA comparing the difference between primary and revision implants (in millimeters) demonstrated that the RRI values were statistically significantly different... | Discussion
Restoration of femoral PCO and near-neutral alignment of the tibial component are statistically significant parameters necessary to achieve more symmetric gaps in this revision TKA cohort. Review of the PI positions from the current cohort frequently revealed a larger distal femoral cut and overresection of ... | Conclusions
This current series demonstrates the authors’ up-to-date experience using the MAKO robotic system for revision TKA. Results of this study indicate that sagittal alignment of the revision implants, specifically the femoral PCO and tibial component slope, are statistically significant considerations for a sta... | Background
The application of robotic-assisted arthroplasty in revision knee scenarios continues to evolve. This study compares the pre- and post-revision implant positions in series of revision total knee arthroplasties (TKA) using a robotic arm system.
Methods
Twenty-five consecutive off-label robotic-assisted revisi... | Limitations
This study includes a cohort of 25 patients from a single institution. A prospective randomized controlled trial comparing manual to robotic revision TKA will be necessary to evaluate long-term outcomes of this technique. Future studies will need to include more patients across several institutions after a ... | Supplementary data
Acknowledgments
The authors would like to acknowledge and thank our MAKO product Specialist for their assistance with this study. Dr. Bullock Serves on the Editorial board for Arthroplasty Today. He will be recused from any peer review and editorial decisions. | CC BY | no | 2024-01-16 23:40:18 | Arthroplast Today. 2023 Dec 27; 25:101310 | oa_package/1e/96/PMC10788208.tar.gz |
PMC10788210 | 38226034 | Experimental Design, Materials and Methods
The serial process through four main steps was conducted to produce a non-commercial tourism dataset in supporting valuable data for research purposes in a smart tourism industry through a tourism recommender systems development as presented in Fig. 2 . Through the WebHarvy c... | The tourism industry has currently grown in various aspects, including the types of attractions, their quantity, and the number of tourist visits in various regions, contributing positively to both regional and global economies. Historical transactions are essential for developing recommender systems, utilizing techniq... | Specifications Table
Value of the Data
• The data values encompass various functionalities and aspects of tourism, including users, items (tourism attractions), ratings, and visiting attributes, all of which are essential inputs for studies in recommender systems. • To facilitate research on recommender systems using... | Data Availability
Tourism Dataset (Original data) (Mendeley Data)
Acknowledgements
This research did not receive any specific grant from public, commercial, or not-for-profit funding agencies.
Declaration of Competing Interest
The authors state that they have no competing financial interests or personal relationsh... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 19; 52:109990 | oa_package/0a/9c/PMC10788210.tar.gz | ||||
PMC10788214 | 38226030 | Experimental Design, Materials and Methods
For the calculation, we have created four atom-based face-centered cubic unit cell and calculated its structural, electrical, and magnetic properties in both regular and inverse Heusler phases. It's worth mentioning here that inverse Heusler phase is a disordered structure of ... | This paper contains data and results from Density Functional Theory (DFT) investigation of 423 distinct X 2 YZ ternary full Heusler alloys, where X and Y represent elements from the D -block of the periodic table and Z signifies element from main group. The study encompasses both “regular” and “inverse” Heusle... | Specification Table
Value of the Data
• This dataset will provide fundamental information about 423 ternary Heusler alloys in their regular ( L2 1 ) and inverse ( XA ) Heusler phases, for a total of 846 distinct alloys calculated. Structure, magnetic properties, and spin polarization values are provided as a launchin... | Data Availability
Dataset on Density Functional Theory investigation of Ternary Heusler Alloys (Original data) (Mendeley Data)
Ethics Statement
The proposed data does not involve any human subjects, animal experiments, or data collected from social media platforms.
Acknowledgement
The author gratefully acknowledge... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 18; 52:109971 | oa_package/10/cd/PMC10788214.tar.gz | ||||
PMC10788215 | 38226035 | In the pursuit of advancing research in continuous user authentication, we introduce COUNT-OS-I and COUNT-OS-II, two distinct performance counter datasets from Windows operating systems, crafted to bolster research in continuous user authentication. Encompassing data from 63 computers and users, the datasets offer rich... | Specifications Table
Value of the Data
• Real-World Applicability: The data collected from public organizations in Brazil offers a realistic environment for testing and validating biometric authentication models. • Comprehensive Data: These datasets encompass various performance counters obtained from the Windows OS,... | Data Availability
Performance counter for biometrics authentication (Original data) (Figshare.com)
Acknowledgements
This research was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES-PROEX)—Finance Code 001. This work was partially supported by Amazonas State Re... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 21; 52:109999 | oa_package/9b/c1/PMC10788215.tar.gz | |||||
PMC10788219 | 38226043 | Experimental Design, Materials and Methods
The population of the data consists of professionals within the construction industry namely Project Managers, Contractors, Engineers, Architects, and Consultants. A total of 150 questionnaires were distributed, 84 via the online SurveyMonkey tool. These included 15 email invi... | This data article explores the factors that contribute to cost overrun on public sector projects within Trinidad and Tobago. The data was obtained through literature research, and structured questionnaires, designed using open-ended questions and the Likert scale. The responses were gathered from project actors and dec... | Specifications Table
Value of the Data
• The data set is the first to provide a methodological classification of the leading root causes of cost overruns in public sector social development housing projects. This is useful in acquiring a deeper understanding of these leading root causes and validated against their th... | Data Availability
Data exploration on the factors associated with cost overrun on social housing projects in Trinidad and Tobago (Original data) (Mendeley Data)
Acknowledgements
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Declaration ... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 15; 52:109966 | oa_package/11/76/PMC10788219.tar.gz | ||||
PMC10788220 | 38226168 | Introduction
Cancer is a major public health problem worldwide and has become one of the most common causes of death. 1 , 2 It can occur in various parts of the body and ultimately lead to serious consequences. For example, lung cancer, specifically non-small cell lung cancer (NSCLC), is the primary cause of respirato... | STAR★Methods
Key resources table
Resource availability
Lead contact
Further information and requests for resources should be directed to and will be fulfilled by the lead contact, Kang Ning (e-mail: ningkang@hust.edu.cn ).
Materials availability
This study did not generate new unique reagents.
Data and code availa... | Results
Sample cohort and experimental design for ovarian cancer group
Serum samples including N-glycans and glycan derived traits were taken from 142 participants, including 40 healthy controls, 50 patients with benign neoplasm and 52 patients with ovarian cancer ( Figure 1 A, discovery cohort, Table 1 ). Based on th... | Discussion
Previous studies have reported that the N-glycome-based classification models can accurately distinguish between healthy individuals and patients with cancer, 39 , 40 demonstrating reliable predictive performance. However, the heterogeneity of data between different cohorts can lead to a decrease in model p... | These authors contributed equally
Lead contact
Summary
Protein glycosylation is associated with the pathogenesis of various cancers. The utilization of certain glycans in cancer diagnosis models holds promise, yet their accuracy is not always guaranteed. Here, we investigated the utility of deep learning techniques, sp... | Supplemental information
Acknowledgments
This work was partially supported by the 10.13039/501100012166 National Key R&D Program of China (Grant No. 2022YFC3400800, 2023YFA1800900 and 2018YFC0910502), the 10.13039/501100001809 National Natural Science Foundation of China (Grant Nos. 3207... | CC BY | no | 2024-01-16 23:40:18 | iScience. 2023 Dec 13; 27(1):108715 | oa_package/de/6a/PMC10788220.tar.gz | ||
PMC10788223 | 38226324 | Introduction
Tea, as a beverage, is popular for its healthy benefits and pleasant flavor. Tea plant is a perennial economic crop which is susceptible to various kinds of destructive foliar diseases due to the warm and humid growth environment in tea plantations that provides a suitable microclimate for the breeding of ... | Materials and methods
Materials
During 2018 to 2020, tea leaves displaying blister blight symptoms were observed in high mountain tea plantations above 1000 m altitude located in Quxian county, Dazhou city, Sichuan province, China (30°85′N, 106°94′E). The typical blister blight symptoms were collected to show the sympt... | Results and discussions
Disease symptoms on tea caused by blister blight disease
As an important tea foliar disease, blister blight mainly infected young organs and tissues including tender leaves, buds, petioles and stems ( Fig. 1 ), directly affecting tea industry qualitatively and quantitatively. The damage to tende... | Results and discussions
Disease symptoms on tea caused by blister blight disease
As an important tea foliar disease, blister blight mainly infected young organs and tissues including tender leaves, buds, petioles and stems ( Fig. 1 ), directly affecting tea industry qualitatively and quantitatively. The damage to tende... | Conclusions
Blister blight is a low temperature and high humidity type disease, which not only endangers the growth and development of tea trees, but also affects tea quality and flavor. The disease symptoms, the spread of disease on tea leaves, and the composition and abundance of fungal community on blister tissues w... | Highlights
• Spread and development of blister blight disease on tea leaves were fully described. • Composition and abundance of fungal community on infected tea leaves were revealed. • Soluble sugars significantly contributed to the enhanced sweetness of diseased tea leaves. • Monosaccharides were the main differentia... | Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. | Supplementary data
The following are the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgements
This work was supported by the 10.13039/501100001809 National Natural Science Foundation of China (NSFC) (32272764) and Chongqing Technology Innovation and Applicatio... | CC BY | no | 2024-01-16 23:40:18 | Food Chem X. 2023 Dec 18; 21:101077 | oa_package/e2/a7/PMC10788223.tar.gz |
PMC10788226 | 38226032 | Experimental Design, Materials and Methods
Rearing of S. frugiperda
In this study, S. frugiperda (instar L4-L5) were freshly collected from maize field crops during 2022, transported in containers, and reared using artificial diet under laboratory conditions [1 , 2] .
DNA Extraction
For DNA extraction and metagenom... | Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae), also known as the fall armyworm, is an economically important and widespread polyphagous pest. Microorganisms associated to this insect during life cycle play important ecological roles. We report 3 metagenome-assembled bacterial genomes reconstructed from a meta... | Specifications Table
Value of the Data
• The Genomes of E. casseliflavus, E. mundtii and L. plantarum can provide insights for the understanding of bacterial interaction with S. frugiperda. • These bacterial genomes data are applicable for comparative genomic and taxonomic purposes. • These data are valuable res... | Data Availability
PRJNA899064 (Original data) (NCBI GenBank).
Acknowledgments
Funding: This study was partially financed by the 10.13039/100008989 Universidad Autónoma de Querétaro (FONDEC-UAQ-2022; FOPER-2022).
Declaration of Competing Interest
The authors declare that they have no known competing financial i... | CC BY | no | 2024-01-16 23:40:18 | Data Brief. 2023 Dec 18; 52:109989 | oa_package/4b/e7/PMC10788226.tar.gz | ||||
PMC10788227 | 38226171 | Introduction
Autoimmune diseases affect approximately 5% of the global population. 1 Biological drugs targeting proinflammatory cytokines are effective; however, disease recurrence during or after treatment is often problematic. 2 One of the cellular targets of such drugs contain interleukin-17 (IL-17)-producing help... | STAR★Methods
Key resources table
Resource availability
Lead contact
Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Shunsuke Chikuma ( schikuma@keio.jp ).
Materials availability
All unique reagents used in this study are available from t... | Results
Pathogenic Th17-dependent mouse model of chronic skin inflammation
We previously reported a Th17-dependent EAD model in mice. 16 Briefly, naive CD4 + T cells extracted from Dsg3H1 mice 15 were purified and activated in vitro under Th17 polarizing condition. Subsequently, when these Th17 cells were transfer... | Discussion
We demonstrated that CD28 blockade selectively inhibits effector Th17 cells that are highly differentiated, leading to the complete inhibition of dermatitis. Traditionally, it has been thought that naive T cells that receive TCR signals without CD28 activation become anergic or unresponsive, thereby contribu... | Lead contact
Summary
IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17 persistence remain unclear. We demonstrated that abatacept, a CD28 antagonist, effectively prevented the development of skin disease in a Th17-d... | Supplemental information
Acknowledgments
The authors thank Akihiro Nohmi and Kazumi Yoshinaga for animal care and Yuko Tanishita and Kaori Yanai for secretarial assistance. We thank Dr. Jeffrey Bluestone (Sonoma Biotherapeutics, USA) for reagents and Dr. Masahiro Okada (RIKEN, Japan), Dr. Kenji Kabashima (Kyoto Uni... | CC BY | no | 2024-01-16 23:40:19 | iScience. 2023 Dec 9; 27(1):108646 | oa_package/37/d3/PMC10788227.tar.gz | ||
PMC10788234 | 0 | Abstract
Introduction
Several studies mentioned parenchymal findings after SARS‐CoV‐2 pneumonia, but few studies have mentioned alterations in the airways. The aim of this study was to estimate the prevalence of tracheomalacia and to analyse the clinical characteristics in a cohort of patients with SARS‐CoV‐2.
Methods
... | To the Editor:
Several studies have found that SARS‐CoV‐2 pneumonia has many respiratory consequences, including clinical, functional and radiological sequelae. 1 Radiologically, numerous parenchymal findings such as ground‐glass opacities, consolidations, reticulation patterns or pulmonary fibrosis have been reco... | ACKNOWLEDGEMENTS
This project was supported by the Fundació Catalana de Pneumologia (FUCAP), Instituto de Salud Carlos III (PI21/01046) and European Regional Development Fund (FEDER). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DATA AVAI... | CC BY | no | 2024-01-16 23:40:19 | Clin Respir J. 2023 Dec 20; 18(1):e13719 | oa_package/93/b2/PMC10788234.tar.gz | |||||
PMC10788235 | 38226094 | Introduction
Stercoral colitis is characterized by inflammation and ulceration of the colonic wall due to fecal impaction [ 1 ]. Patients with stercoral colitis often present with abdominal pain, distension, constipation, and sometimes rectal bleeding. These symptoms are nonspecific and can mimic other colonic diseases... | Discussion
A retrospective review of 49 patients noted that the rectosigmoid colon was the most frequently involved segment in stercoral colitis. CT findings typical of stercoral colitis include dilatation >6 cm, wall thickening >3 mm of the affected colon segment, pericolonic fat stranding, mucosal discontinuity, and ... | Conclusions
Stercoral colitis is a potentially fatal condition that requires prompt recognition and management. Opiate use is a significant risk factor that has become more prevalent. Early intervention is crucial to improve patient outcomes and reduce the risk of life-threatening complications. | The authors present the case of a 62-year-old woman who had stercoral colitis secondary to opiate use for rheumatoid arthritis leading to chronic constipation. Computed tomography imaging demonstrated stool along a significant length of the colon. Stercoral colitis is a seldom suspected cause of severe abdominal pain. ... | Case presentation
A 62-year-old female with a past medical history of rheumatoid arthritis, hemorrhoids, and chronic constipation secondary to opiate pain medication use presented to the emergency department (ED) for constipation. She stated her last bowel movement was three days prior; however, her stool was hard, and... | CC BY | no | 2024-01-16 23:40:19 | Cureus.; 15(12):e50511 | oa_package/7c/5e/PMC10788235.tar.gz | |||
PMC10788236 | 38226084 | Introduction
Rheumatoid arthritis (RA) is a systemic autoimmune disease that mainly affects the joints, which can lead to joint deformity. Since the disease is systemic, it affects many organs, including the heart, which can lead to coronary artery disease, pericarditis, and heart failure [ 1 ]. The most common cardiac... | Discussion
Pericarditis is a well-known extra-articular manifestation of RA. However, it is unusual for pericarditis to present in undiagnosed RA and as the first presentation of the disease. Few reported cases are similar to this patient’s. RA can cause a variety of cardiac manifestations, although pericarditis is the... | Conclusions
We reported an unusual presentation of RA in which the patient presented with shortness of breath and chest pain. Extensive workup was done for the patient, and he was diagnosed with RA complicated with pericardial effusion. The patient did not have typical joint pain from RA. The patient underwent pericard... | Rheumatoid arthritis (RA) is a systemic autoimmune disease that mainly affects the joints, which can lead to joint deformity. Since the disease is systemic, it affects many organs, including the heart, which can lead to pericarditis, coronary artery disease, and heart failure. We are reporting on a male patient, 34 yea... | Case presentation
The 34-year-old Sudanese male, who was not known to have a chronic medical history, was referred from another hospital as a case of pericardial effusion and failed pericardiocentesis without reaching any diagnosis. The patient complained of shortness of breath and chest pain that started three weeks b... | CC BY | no | 2024-01-16 23:40:19 | Cureus.; 15(12):e50489 | oa_package/dc/f4/PMC10788236.tar.gz | |||
PMC10788237 | 38226130 | Introduction and background
Avascular necrosis (AVN), also known as osteonecrosis, is a debilitating condition characterized by the death of bone tissue due to a lack of blood supply. This phenomenon predominantly affects weight-bearing joints, such as the hip and knee, and can lead to significant pain, joint dysfuncti... | Conclusions
In conclusion, AVN presents a multifaceted challenge in orthopaedic and rheumatologic practice. This comprehensive review has highlighted vital findings, emphasizing the importance of early detection and a multidisciplinary approach to care. From recognizing aetiological factors and clinical presentations t... | Avascular necrosis (AVN), characterised by compromised blood supply leading to bone necrosis, poses a significant challenge in orthopaedic and rheumatologic practice. This review comprehensively examines early AVN treatment strategies, including aetiology and risk factors, clinical presentation, conservative and surgic... | Review
Aetiology and risk factors
Traumatic Causes
Fractures and dislocations: Traumatic fractures and dislocations pose substantial risks for the development of AVN. These events have the potential to disrupt the blood vessels supplying the affected bone, resulting in ischemia, a condition where blood flow to the bone... | CC BY | no | 2024-01-16 23:40:19 | Cureus.; 15(12):e50510 | oa_package/d9/ea/PMC10788237.tar.gz | ||||
PMC10788238 | 38226089 | Introduction
The female genital system is an intricate but intriguing structure that includes the external and internal genitalia, uterus, ovaries, fallopian tubes, and vagina. One of the most significant female reproductive organs is the uterus, which is also known as the womb and cervix. They are susceptible to both ... | Materials and methods
Study design
This is a hospital-based retrospective observational study.
Place and duration of study
This study was carried out in the Pathology Department at Datta Meghe Medical College, Wanadongari, Nagpur, from February 2022 to January 2023.
Sample size
A total of 110 women who presented to th... | Results
This study included 110 patients. The age distribution of the hysterectomy specimens is presented in Table 1 . Hysterectomies were performed in women aged between 25 and 75 years of age. The majority of cases, 47 (42.72%) of these 110 cases, occurred between the ages of 35 and 45 years, followed by 32 (29.09%)... | Discussion
Hysterectomy is the most prevalent gynecological operation worldwide. It is an effective procedure to alleviate symptoms and provide patient contentment and offers a permanent solution for many disorders affecting the uterus and adnexa [ 6 ]. In this study, the age range of the patients was 25 to 75 years, w... | Conclusions
The present study offers a good understanding of the histopathological patterns of lesions in hysterectomy specimens from our institution. The most prevalent uterine pathology is leiomyoma; the most prevalent ovarian lesion is a follicular cyst; and chronic cervicitis is the most frequently found incidental... | Introduction
The uterus is a crucial reproductive organ that is susceptible to the development of several non-neoplastic and neoplastic diseases in women, greatly increasing morbidity and mortality. Although there are various therapeutic options, hysterectomy is still a popular treatment option throughout the world. Ab... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50497 | oa_package/79/8e/PMC10788238.tar.gz | ||
PMC10788239 | 38226120 | Introduction
Esophageal cancer is known to be a deadly malignancy and represents the fifth most common gastrointestinal cancer in the United States with approximately 16,940 new cases per year [ 1 ]. Histologically, esophageal cancers are mainly identified as squamous cell carcinoma (SCC) or adenocarcinoma (ACA). There... | Discussion
Dysphagia is typically the predominant symptom in patients with SCC of the esophagus and often leads to weight loss and malnutrition [ 2 ]. Because esophageal cancer is often first diagnosed at an advanced stage, a great number of patients require some form of palliative treatment to relieve the esophageal s... | Conclusions
Esophageal SCC should be suspected in the setting of non-specific symptoms such as dysphagia, weight loss, and retrosternal discomfort. Typically, treatment options include esophageal or surgical resection along with neoadjuvant chemoradiation of resectable lesions. However, the placement of an esophageal s... | Esophageal cancer is typically identified as squamous cell carcinoma or adenocarcinoma. There are multiple risk factors that may contribute to esophageal squamous cell carcinoma including smoking, alcohol consumption, and the human papillomavirus. Lesions may appear ulcerated, friable, and circumferential and may obstr... | Case presentation
A 73-year-old female with a past medical history of chronic obstructive pulmonary disease (COPD) and hypertension presented to the emergency department due to symptoms of exacerbated dysphagia for the past three months. She endorsed dysphagia to solids initially, but progressively complained of dyspha... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50483 | oa_package/89/48/PMC10788239.tar.gz | |||
PMC10788240 | 38226078 | Introduction
The medical challenges faced by foreigners or immigrants in accessing healthcare in foreign countries, which result in health disparities and deterioration in health conditions, can be viewed as universal health inequities [ 1 - 3 ]. Indeed, foreign residents may need help utilizing medical services due to... | Materials and methods
Study site
The study site was in Tokyo, where the number of foreign residents was reported to be approximately 540,000, accounting for about 20% of the foreign population living in Japan in 2022 [ 10 ]. Particularly in Tachikawa City, which has a population of over 180,000, there are around 4,650 ... | Results
Table 1 presents the results of the visit list. During the study period, a total of 124 foreign patients had consultations using human-mediated translation services. Of these, 69 (56%) were male, and 55 (44%) were female. The median age was 35 years, ranging from 3 to 61 years. By age group, there were six pa... | Discussion
The results of this study demonstrate a clear need for human-mediated translation services, particularly for foreign residents visiting Navitas Clinic Tachikawa in Tokyo. During the study period, 124 foreign patients utilized human-mediated translation services, indicating a significant demand for language i... | Conclusions
In conclusion, this study underscores the vital importance of human-mediated translation services in enhancing healthcare accessibility for foreign residents in Japan, emphasizing their diverse linguistic needs and varied medical services they utilize. Future research should focus on expanding the scope of ... | Introduction
Foreign residents in Japan often face challenges accessing healthcare due to language barriers, potentially leading to health inequities. This study aimed to assess the utilization and impact of human-mediated translation services in a specific medical setting in Tokyo.
Methods
A retrospective investigatio... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50493 | oa_package/f6/e0/PMC10788240.tar.gz | ||
PMC10788241 | 38226129 | Introduction
Heart failure (HF) is a complex clinical syndrome caused by a structural or functional cardiac disorder that results when the heart cannot provide the body with sufficient blood supply [ 1 - 3 ]. The most common cause of HF is when the left ventricular myocardial function is reduced, followed by the dysfun... | Materials and methods
This cross-sectional study was conducted between October 2022 and February 2023. The study includes participants over 18 who live in Makkah. Participants who refused to participate in the study were excluded.
The sample size was calculated using Open Epi software v2.1 ( www.OpenEpi.com ) [ 13 ]. T... | Results
A total of 1,053 participants who met the inclusion criteria completed the study questionnaire. The mean age of the participants was 33.5 (13.2) years, ranging from 18 to 70 years old. Additionally, 558 (53%) of the study participants were male, and 495 (47.0%) were female. The most predominant nationality of t... | Discussion
Although HF has a poor prognosis and that more than 40% of patients die within the first year of their first hospitalization, the awareness of HF in Europe remains unsatisfactory. Studies regarding the awareness among the Middle Eastern population are lacking as well (6,11,12). Therefore, this study assesses... | Conclusions
The focus of this study was to assess the awareness and perception of HF among the population in Saudi Arabia. Most participants had heard of HF, and the majority correctly defined it. However, multiple flaws exist in their understanding of numerous aspects of the disease, requiring more educational program... | Background
Heart failure (HF), a major public health problem worldwide, is a complex clinical syndrome caused by structural or functional heart disorders occurring when the heart cannot supply sufficient blood to the body. The most common cause of HF is impairment of the left ventricle. Public awareness of HF is critic... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50504 | oa_package/36/cd/PMC10788241.tar.gz | ||
PMC10788242 | 38226105 | Introduction
Bacillus Calmette-Guérin (BCG) therapy stands as a pivotal modality in the treatment arsenal for non-muscle invasive bladder cancer (NMIBC), offering a unique approach through immunotherapy [ 1 ]. The treatment involves the intravesical instillation of live attenuated Mycobacterium bovis, derived from the... | Discussion
BCG for bladder cancer is one of the oldest forms of immunotherapy [ 1 ]. A diagram depicting its mechanism of action can be seen in Figure 2 . While BCG is effective for both immunocompetent and immunocompromised patients, it can lead to systemic side effects in 30%-40% of patients and potentially life-thr... | Conclusions
In conclusion, BCG therapy remains a cornerstone in the management of NMIBC, exhibiting efficacy in reducing tumor recurrence. However, the presented case underscores the intricate challenges associated with BCG treatment, including chemical cystitis and severe sepsis and the differential diagnosis of the r... | This case report presents a 66-year-old male with a complex medical history, including testicular cancer, chronic obstructive pulmonary disease, obstructive sleep apnea, tobacco use disorder, erectile dysfunction, and obesity. The patient exhibited recurrent gross hematuria, leading to a comprehensive workup. Cystoscop... | Case presentation
A 66-year-old male patient presented with a history of testicular cancer (managed with radical orchiectomy), chronic obstructive pulmonary disease, obstructive sleep apnea, tobacco use disorder, erectile dysfunction, and obesity. The patient presented with gross hematuria persisting for approximately ... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50498 | oa_package/c9/8a/PMC10788242.tar.gz | |||
PMC10788243 | 38226080 | Introduction
Meningiomas are slow-growing neoplasms carrying a favorable prognosis, especially when entirely resected and in younger patients [ 1 ]. Accounting for 15-20% of all brain tumors, they rarely extend beyond the cranial boundaries and usually associate osteolytic changes in the skull [ 2 ]. Primary extracrani... | Discussion
As stated before, histology defines five patterns of these tumors, of which syncytial (meningothelial) ones are most prevalent among the primary extracranial meningiomas [ 3 ]. A neoplasm composed of spindle-shaped cells with whorls, without any indication of atypia, suggests a meningothelial origin [ 6 ]. A... | Conclusions
In wrapping up our discussion about this patient’s fascinating medical case, we have unraveled significant aspects regarding the pathology of meningiomas. Our female patient possesses all the factors that make insightful contributions to the condition she experienced as follows: her advanced age, her clinic... | The study reflects on a 69-year-old female patient with a history of cardio-respiratory disorders who was diagnosed with meningioma en plaque. Her clinical management entailed surgical resection of the tumor, which was followed by a complex postoperative course, including cardiorespiratory arrest and respiratory failur... | Case presentation
This is a case of a 69-year-old patient with a known history of cardio-respiratory disorders, such as atrial fibrillation with medium rhythm and bilateral bronchopneumonia. Neurological examination reveals left hemiparesis, intracranial hypertension syndrome, cerebral edema, and cerebrospinal fluid (C... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50490 | oa_package/65/b0/PMC10788243.tar.gz | |||
PMC10788244 | 38226081 | Introduction
Advances in genetic technologies have made genetic testing more accessible than ever before, with whole exome sequencing (WES) gaining popularity. However, the actual need for daily genetic testing more often revolves around targeted gene analysis rather than comprehensive examination. In the case of rare ... | Materials and methods
This study was performed at the Center for Clinical Genomics, Kanazawa Medical University Hospital, Uchinada, Japan. Since 2013, we have been contracting out genetic testing for various genetic diseases from in-hospital and out-of-hospital facilities in Japan. A total of seven patients were enroll... | Results
As a result, vLAS was implemented extremely efficiently. Long-range PCR amplification products of COL1A1, COL1A2, and COL2A1 were able to be stably obtained from all patient samples. The IGV image of sequencing results showed that the genomic region of each gene was covered extremely uniformly including all ove... | Discussion
With advances in DNA sequencing technology, WES and whole genome sequencing (WGS) have become increasingly available. However, in clinical genetic practice, there is often a need for genetic testing focused on individual diseases rather than a comprehensive analysis. Nevertheless, there are limited applicati... | Conclusions
Streamlining the genetic diagnosis of type I and type II collagenopathies has been achieved with vLAS. vLAS is extremely useful for genetic diagnosis when the target genes can be narrowed down from the clinical diagnosis. It is easy to set up a new test system, and it is possible to detect a wider range of ... | In the practice of clinical genetics, gene testing is usually guided by clinical diagnosis. When dealing with rare diseases, it is often necessary to create new test systems. The handling of a gene with a substantial number of exons poses a challenge both in sequential Sanger sequencing for each exon, and in the setup ... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50482 | oa_package/f0/b1/PMC10788244.tar.gz | ||
PMC10788245 | 38226076 | Introduction
Being overweight and obesity are defined as abnormal or excessive fat accumulation that presents a serious health risk. A body mass index (BMI) of 25 or more is considered overweight, while 30 or more is obese [ 1 ]. Within the past several decades, there has been a significant increase in the prevalence o... | Materials and methods
The study employed a cross-sectional design, utilizing a self-administered questionnaire for data collection. The research was conducted in the Al-Qassim Region over a period of 12 months. To determine the sample size, Yamane’s Formula was applied, considering a target population of 1.52 million p... | Results
The participants’ sociodemographic data
A total of 988 participants agreed to participate in the study, and their sociodemographic characteristics are presented in Table 1 . Specifically, 61.20% (n=605) of the participants were females and had a university education 69.9% (n=691). With respect to age groups (m... | Discussion
Obesity is a major public health concern that is associated with numerous health problems, including diabetes, heart disease, and certain types of cancer [ 11 ]. Locally, obesity in Saudi Arabia is sitting at 24%; however, when compared to previous years, this number is lower [ 12 ]. As for why this is happe... | Conclusions
In conclusion, this study underscored the pressing need to address the stigma and misconceptions associated with bariatric weight loss surgery in the Al-Qassim Region. Societal attitudes’ effect on individuals who have undergone these procedures is evident and leads to feelings of shame and hesitation among... | Background
Obesity is defined as abnormal or excessive fat accumulation that presents a serious health risk and is a major public health concern. Obesity prevention and management require evidence-based strategies that emphasize diet and physical activity. Bariatric surgery is also a life-changing procedure that can im... | Appendices
Questionnaire
Demographic Characteristics
Age: _________
Gender:
o Male
o Female
Weight (kg):_____________
Height (cm):_____________
Education Level:
o Elementary
o Middle School
o High School
o College (Non-health Major)
o College (Health Major)
o Post-graduate
o Other:_____
1 - Obesity
... | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50477 | oa_package/36/9b/PMC10788245.tar.gz | |
PMC10788246 | 38226073 | Introduction
Currarino syndrome (CS) is a rare disease with an incidence of approximately one in 100,000 [ 1 ], characterized by three clinical features: presacral mass, anorectal malformation, and sacral bone deformity. Some variants of this “Currarino triad” require not only pediatric surgery but also neurosurgery. T... | Materials and methods
The present, retrospective review of the records of patients with Currarino syndrome (CS) who underwent surgery for the disease was approved by the Institutional Review Board of Tokyo Metropolitan Children’s Medical Center. The present study was approved by the Institutional Review Board (Research... | Results
Patient background
All seven patients with CS with associated anorectal stenosis treated at our hospital were subadult females. Their median age at CS diagnosis was eight months (range: 1-18 months). The primary symptoms were abdominal distension in three patients, constipation in two patients, sacral skin depr... | Discussion
CS is a secondary neural tube dysplasia in which the anterior wall of the spine is formed in the fourth week of embryonic development and the gastrointestinal tract and neural tube are separated. Currarino et al. [ 2 ] and several other authors [ 4 , 5 ] suggested that a neuro-enteric fistula is formed in th... | Conclusions
We reviewed seven patients with CS who underwent treatment in our hospital and proposed a protocol to optimize the treatment flowchart. Since CS has a wide spectrum of clinical presentations, there is no consensus on the therapeutic protocol. Consequently, there is a chance of missing the diagnosis at the i... | Purpose: The present study aimed to review the treatment experience and outcomes of Currarino syndrome (CS) complicated with anorectal stenosis to evaluate the current treatment strategies.
Methods: Seven cases of CS complicated with anorectal stenosis, treated at our hospital between 1998 and 2021, were retrospectivel... | We wish to acknowledge Dr. Satoshi Ihara, a pediatric neurosurgeon at Tokyo Metropolitan Children’s Medical Center, for his help in interpreting the neurosurgical findings, and thank Mr. James Robert Valera for his assistance with editing this manuscript. | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50512 | oa_package/b4/5e/PMC10788246.tar.gz | |
PMC10788247 | 38226115 | Introduction and background
Vitamin A is a fat-soluble vitamin essential in the normal nonpathogenic functioning of many human body processes. It plays an important role in eye development, prevention of blindness, bone development, skin and mucosa protection, and immunity, and aids in the development of epithelial tis... | Conclusions
The pregnant mother must weigh the need for an adequate supply of vitamin A to avoid deficiency against excess consumption, potentially leading to teratogenicity. The unregulated use and lack of education on the teratogenic effects of vitamin A multivitamins and supplements in developed countries make it mu... | Vitamin A deficiency (VAD) or excess in expectant mothers can result in fetal abnormalities such as night blindness, bone anomalies, or epithelial cell problems. In contrast, excessive vitamin A in pregnancy can precipitate fetal central nervous system deformities. During pregnancy, a pregnant woman should monitor her ... | Review
Vitamin A overview
Vitamin A is a fat-soluble vitamin found naturally in many foods, including fruits, vegetables, and animal-based products. It is crucial for the normal functioning of many distinct functions of the human body, such as visual adaptation, immunity, and epithelial cell differentiation [ 5 ]. Once... | The authors wish to acknowledge the Paolo Procacci Foundation for its generous support in the publication process. | CC BY | no | 2024-01-16 23:41:56 | Cureus.; 15(12):e50513 | oa_package/3f/ac/PMC10788247.tar.gz | |||
PMC10788254 | 38226357 | Background
The fabric of a rock or sediment is related to the spatial and geometric configuration of the particles that compose it. In sedimentary rocks, fabric is a property that depends on the depositional environment and can provide information about the directions of the currents at the time of deposition. For this... | Method details
Background
The fabric of a rock or sediment is related to the spatial and geometric configuration of the particles that compose it. In sedimentary rocks, fabric is a property that depends on the depositional environment and can provide information about the directions of the currents at the time of depos... | Fabric analysis is essential for understanding the evolution of volcaniclastic deposits. Here we present a comprehensive and efficient methodology, called “Clast shape-fabric analysis,” which is part of the Quantitative Textural Analysis (QTA). This methodology combines high-resolution image analysis techniques with ge... | Specifications table
Method details
In order to accurately measure the shape-fabric of a sample from a volcanoclastic deposit, and obtain reliable and reproducible data, it is necessary to follow a specific procedure ( Fig. 2 ).
Sampling
Location and orientation of samples are among the most important aspects of the pr... | Data availability
No data was used for the research described in the article.
Acknowledgment
CONAHCYT grants 1075397, 210817, FAI Project UASLP C19-FAI-05-83.83, British Royal Society Project NAF-R2-180833, Instituto de Geología UASLP and Maestría en Ciencias del Procesamiento de la Información, UAZ. | CC BY | no | 2024-01-16 23:41:57 | MethodsX. 2023 Dec 13; 12:102519 | oa_package/a9/02/PMC10788254.tar.gz | |||
PMC10788261 | 38226283 | Introduction
Infectious diseases were responsible for billions of deaths before 1980 [ 1 ]. Many infectious diseases have been brought under control, and their associated mortality rates have reduced significantly thanks to developments in medical treatment, public health interventions, and countermeasures (diagnostics... | Material and methods
Collection of human sera and plasma
In a cross-sectional study conducted between March 2020 and July 2021, 100 volunteers without underlying diseases provided serum samples with negative SARS-CoV-2 RT-PCR results. The volunteers were screened and classified into three groups of healthy, convalescen... | Results
Screening and categorization of healthy, convalescent, and vaccinated individuals
One hundred volunteers with negative results for SARS-CoV-2 RT-PCR were tested with an ELISA to determine their antibody levels against the S and N proteins. Positive samples for anti-S and anti-N were deemed convalescent, whereas... | Discussion
Multiple methods can be used to prepare passive immunotherapy from human and animal sources. The utilization of convalescent or vaccinated human plasma is a common passive immunotherapy method [ 14 ]. According to a study by Hung et al., the administration of convalescent plasma to influenza A (H1N1) patient... | The use of passive immunotherapy, either as plasma or purified antibodies, has been recommended to treat the emerging infectious diseases (EIDs) in the absence of alternative therapeutic options. Here, we compare the neutralization potency of various passive immunotherapy approaches designed to provide the immediate ne... | Funding
Mazandaran University of Medical Sciences provided the funds for this research project (Grant No. 7306).
Data availability statement
Data will be made available on request. No data associated with this study has been deposited into a publicly available repository.
Ethics declarations
This study was reviewed and... | Acknowledgements
Figures were created using BioRender software ( https://biorender.com ). | CC BY | no | 2024-01-16 23:41:57 | Heliyon. 2023 Dec 16; 10(1):e23478 | oa_package/1e/aa/PMC10788261.tar.gz | |
PMC10788266 | 37903929 | Introduction
Cell and gene therapies (CGTs) are in the vanguard of modern medicine. There are more than 3500 CGTs currently in development targeting a wide array of diseases, including cancer, amyotrophic lateral sclerosis, sickle cell disease, and acquired immune deficiency syndrome, as well as many rare genetic disea... | Materials and Methods
Stakeholder framework and mapping
The core stakeholder framework and mapping for CGT delivery was informed by the existing literature in addition to the websites and online documentation of relevant pharmaceutical, governmental, academic, and information technology sectors. A major source of infor... | Results
Developing a framework for core CGT stakeholders for CGT delivery
The evolution of the current linear and centralized delivery model of CGT into a nonlinear hub and spoke model requires a detailed understanding and mapping of the current and potential roles of relevant stakeholders. The stakeholders involved in... | Discussion
Access to CGTs varies massively, with LMICs less likely to benefit, especially given the prohibitive cost associated with such therapies. The preliminary, adaptable roadmap for more equitable CGT delivery in LMICs we propose aims to increase access to CGTs in these countries, but the hub and spoke model is a... | In the rapidly evolving landscape of biotechnologies, cell and gene therapies are being developed and adopted at an unprecedented pace. However, their access and adoption remain limited, particularly in low- and middle-income countries (LMICs). This study aims to address this critical gap by exploring the potential of ... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41434-023-00425-x.
Acknowledgements
Editorial support was provided by Jennifer Weintraub of Kay Square Scientific, Newtown Square, PA, USA. This support was funded by Novartis Gene Therapies, Inc.
Author contributions
Con... | CC BY | no | 2024-01-16 23:41:57 | Gene Ther. 2024 Oct 30; 31(1-2):1-11 | oa_package/81/23/PMC10788266.tar.gz | |
PMC10788267 | 38225934 | Introduction
Glycosylphosphatidylinositol (GPI) anchors various proteins to the plasma membrane. There are over 150 types of GPI-anchored proteins (GPI-APs) in mammalian cells, and they play various roles in fertilization, development, and immune responses as enzymes, adhesion molecules, receptors, and complement regul... | Materials and methods
Generation and genotyping of mice
Piga -floxed mice were generated in our laboratory. 4 CNS-specific Cre expressing transgenic mice, B6.Cg-Tg( Nestin-Cre ) RBRC02412, were provided by the RIKEN BioResource Research Center through the National BioResource Project of the Ministry of Education, Cult... | Results
Generation and phenotypes of CNS-specific Piga KO mice
Nestin-Cre transgenic male mice were crossed with homozygous Piga -floxed female mice to induce Cre-mediated deletion of Piga exon 6 in neurons ( Figure 1 A). Percentages of exon 6-depleted alleles relative to Piga -floxed and wild-type alleles were ... | Discussion
PIGA is a catalytic subunit of the enzyme complex involved in the first step of GPI biosynthesis. Because PIGA is an X-linked gene, males who receive the maternal pathogenic allele develop the disease. Therefore, the frequency of PIGA deficiencies is higher than that of other IGDs, with approximately 100... | Thirty genes are involved in the biosynthesis and modification of glycosylphosphatidylinositol (GPI)-anchored proteins, and defects in these genes cause inherited GPI deficiency (IGD). PIGA is X-linked and involved in the first step of GPI biosynthesis, and only males are affected by variations in this gene. The main... | Data and code availability
All of the data are available from the corresponding author on reasonable request. | Supplemental information
Acknowledgments
We thank Andrew Kwon, PhD, for connecting us to Steven and Ann Nguyen, the parents of the PIGA-CDG patient Emmett Nguyen. We thank Junji Takeda and Takahiro Kodama (Osaka University) for discussion, Masahito Ikawa (Osaka University) and Gen Kondoh (Kyoto University) for he... | CC BY | no | 2024-01-16 23:41:57 | Mol Ther Methods Clin Dev. 2023 Dec 14; 32(1):101176 | oa_package/f4/ad/PMC10788267.tar.gz | |
PMC10788271 | 37542151 | Introduction
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and its incidence increases with aging [ 1 ]. In idiopathic PD, the vulnerability and dysfunction of the dopaminergic neurons that causes their death produce an imbalance between the direct and the indirect basal ganglia pathw... | Materials and methods
Sequence and cloning
The lentiSAMv2 and lentiMPH v2 plasmids (a gift from Feng Zhang Addgene #75112 and #89308) were used for CRISPR-Cas9 activation. We analyzed the promoter region of the rat th gene, 1000–1200 bp upstream of the transcription start site, searching for PAM regions. We obtained ... | Results
CRISPR activation screening for Th expression
We analyzed the promoter region of the rat genome using the DNA sequence from the Gene library of NIH (Gene ID: 25085, Norway rat chromosome 1) to determine potential th sgRNAs, as described in the methodology. We chose sequences with the highest specificity sco... | Discussion
This work is a proof-of-concept experiment using a CRISPR-Cas9 system to treat a neurodegenerative disease. The strategy of this experiment is based on the fact that the expression of Th induces the synthesis of DA in astrocytes since it is the only enzyme absent in astrocytes to complete the biosynthetic pa... | Parkinson`s disease (PD) is the second most prevalent neurodegenerative disease, and different gene therapy strategies have been used as experimental treatments. As a proof-of-concept for the treatment of PD, we used SAM, a CRISPR gene activation system, to activate the endogenous tyrosine hydroxylase gene ( th ) of as... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41434-023-00414-0.
Acknowledgements
We want to thank Araceli Navarrete and Paula Vergara for invaluable technical assistance; Ivan José Galván for his technical support in the acquisition of the images and the LaNSE con... | CC BY | no | 2024-01-16 23:41:57 | Gene Ther. 2024 Aug 4; 31(1-2):31-44 | oa_package/e2/d1/PMC10788271.tar.gz | |
PMC10788274 | 38225952 | Background
Allergic rhinitis (AR)/rhinoconjunctivitis (ARC) is a disorder of the nose and eyes affecting about one-fifth of the general population primarily driven by an immunoglobulin E (IgE)-mediated type I hypersensitivity response, due to an allergen exposure. 1 , 2 In Europe, the prevalence of diagnosed AR was re... | Methods
Study design and materials
The study design, set up, and results of the large, international, double-blind, placebo-controlled, phase 3 trial (EudraCT 2014-004223- 46 and ClinicalTrials.gov NCT 02443805) have already been published. 25 Here we report the results observed in the 91 centers from 9 EU countries... | Results
Study patients
Of the 1607 adults and adolescents randomized in this trial, 992 were recruited in European centers and treated either with the 300 IR HDM tablet (N = 498) or with placebo (N = 494). The modified full analyisis set (mFAS) comprised 818 EU patients (384 in the 300 IR group and 434 in the placebo g... | Discussion
The present study aimed to evaluate post hoc the results of the EU population that participated in the recently published international, randomized, placebo-controlled, phase 3 clinical trial with the 300 IR HDM sublingual tablet, 25 with a focus on 2 balanced symptom and medication scores following recomme... | Conclusion
The post hoc data from the international, randomized, placebo-controlled clinical trial focusing on the European HDM-AR adults and adolescents confirm the efficacy and safety of the 300 IR HDM SLIT tablet during the first year of treatment. The results were even better than those observed in the overall popu... | Background
House dust mite (HDM)-induced allergic rhinitis (AR) is a major cause of allergic respiratory disease. The efficacy and safety of the 300 IR HDM sublingual immunotherapy (SLIT) tablet in patients with moderate-to-severe HDM-AR was confirmed in a large, international, phase 3 randomized controlled trials (RCT... | Abbreviations
AIT, Allergen Immunotherapy; ANCOVA, Analysis of Covariance; AR, Allergic Rhinitis; ARC, Allergic Rhinoconjunctivitis; ARIA, Allergy and its Impact on Asthma Initiative; CI, Confidence Interval; CSMS, Combined Symptom and Medication Score; DMS, Daily Medication Score; EAACI, European Academy of Allergy an... | Supplementary data
The following is the Supplementary data to this article:
Acknowledgments
We thank all the investigators, nurses, and participants who made this study possible, and all members of the SL75.14 clinical trial for their commitment to the study. Post hoc statistical analyses have been provided by Catherin... | CC BY | no | 2024-01-16 23:41:57 | World Allergy Organ J. 2023 Dec 22; 17(1):100849 | oa_package/94/98/PMC10788274.tar.gz |
PMC10788280 | 38154447 | INTRODUCTION
Over the years, the poultry industry has undergone changes to meet increasing demand for meat from the global population and minimize economic losses. Furthermore, in commercially-raised birds, such as broilers and laying hens, understanding body composition is valuable for various purposes, including bree... | MATERIALS AND METHODS
Ethics
Experiments were conducted to create regression equations (Trial 1) and for equation validation (Trial 2). All procedures adopted for both trials were previously approved by the Ethics Committee in the Use of Farming Animals at the Universidade Federal de Viçosa ( CEUAP-UFV ) under the acc... | RESULTS
Variation in Body Composition of Broiler Chickens
Variation in body composition of broiler chickens of different ages for Trial 1 and Trial 2 was achieved; the means with the coefficient of variation are shown in Table 1 . Regardless of birds’ ages or analysis method (DEXA or chemical), and in both trials, bod... | DISCUSSION
The first Trial aimed to compare the DEXA scanner estimates against chemical carcass analysis of broilers aged 1 to 42 d and to establish reliable predictive linear regression equations. Chemical analysis is still the gold standard for measuring chicken broiler composition, and consequently, DEXA accuracy ca... | CONCLUSIONS
The linear models for chicken body composition prediction validated in this study are possibly specific to particular equipment, software version, and procedures (such as bird positioning and ROI specifications). Nonetheless, the same equation structures can be adapted to new data using different DEXA scann... | Two trials were carried out to develop and validate linear regression equations for body composition prediction using Dual-energy X-ray absorptiometry ( DEXA ). In Trial 1, 300 Cobb500 male chickens raised from 1 to 42 d of age were scanned in DEXA to estimate total weight, fat mass, soft lean tissue ( SLT ) mass, bone... | Supplementary materials
ACKNOWLEDGMENTS
Gustavo A. C. C. de Aguiar is a doctoral researcher funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (no 88887.510984/2020-00). Gabriel R. Braga is a undergraduate student funded by scientific initiation program of Fundação de Amparo ... | CC BY | no | 2024-01-16 23:41:57 | Poult Sci. 2023 Dec 9; 103(2):103363 | oa_package/35/06/PMC10788280.tar.gz | |
PMC10788281 | 38226212 | Introduction
The climate crisis is one of the grand societal challenges. At all levels of governance, nation states must take far-reaching measures to counteract the already dramatic effects of the climate crisis. Austrian social service and healthcare (SSHC)-nonprofit-organizations (NPOs), on which the empirical part ... | Methodology and sample
A total of 22 expert interviews were conducted with 29 top management representatives from 21 Austrian SSHC-NPOs since autumn 2022. The interview guideline contained open-ended questions and covered the following thematic blocks: interviewees' understanding of sustainability, operational and stra... | Results
Strategic relevance of sustainability
Understanding of sustainability
In the interview section focusing on the organizational and personal understanding of sustainability, most of the interview time was dedicated by the interviewees to the environmental dimension of sustainability. Some interviewees provided ... | Discussion
The awareness of the general relevance of the environmental dimension of sustainability is high within the focused SSHC-NPOs. Regarding our overall research question „How well are Austrian SSHC-NPOs prepared to comply with the CSRD requirements regarding environmental matters?“, the findings of our study s... | Conclusions
The paper contributes to the academic debate in the following ways: Empirically, by focusing on the status quo and the envisaged steps of SSHC-NPOs towards the CSRD, the paper addresses a timely and highly under-researched field. Austrian SSHC-NPOs have a wait-and-see attitude toward the coercive pressures ... | The climate crisis requires the systematic integration of environmental matters into the management practices of companies across all sectors. The 2022 Corporate Sustainability Reporting Directive (CSRD) has created a need in many large social service and healthcare non-profits (SSHC–NPOs) within the European Union to ... | Conceptual and theoretical background
Conceptual background
There are several approaches which highlight the different MC types within management control systems (MCS) [e.g., [34] , [35] , [36] ]. The most holistic one is the approach by Malmi and Brown [ 37 , 38 ], which places a special emphasis on the package ide... | CC BY | no | 2024-01-16 23:41:57 | Heliyon. 2023 Dec 24; 10(1):e23767 | oa_package/b0/a0/PMC10788281.tar.gz | |
PMC10788286 | 38226207 | Introduction
Processed excipients are essential components of pharmaceutical and medical products. They serve various functions, such as ensuring stability, improving drug delivery, and enhancing patient compliance. Excipients are inactive substances that are combined with active pharmaceutical ingredients (APIs) to cr... | Isolated/enucleated organ/organotypic methods
Optometric and spectroscopic methods are commonly employed in protocols for evaluating ocular effects to quantitatively assess changes in the isolated cornea caused by a test substance. These methods are usually followed by histological analysis to provide further insights.... | Conclusion
Ocular preparatory transmission is a complex and continuing experience that necessitates the development of effective and targeted strategies. Although several methods are available, such as topical drops, injections, and systemic delivery, sustaining effective medication concentration for a prolonged time c... | Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the efficacy and safety of ocular drug delivery systems. This comprehensive overview examines the opportun... | Effects of physiological factors on ocular drug delivery approaches
The designing and development of drug delivery systems targeting ocular tissues poses a significant challenge for scientists. The eye is alienated into frontal and later chambers, and each layer of ocular tissue presents structural variations that hind... | Acknowledgments
Sumel Ashique would like to acknowledge the Bharat Institute of Technology, India for providing all the facilities to draft the manuscript. Sourav Mohanto would like to acknowledge Yenepoya (Deemed to be University), India for providing the facilities to carry out the research-oriented activities. | CC BY | no | 2024-01-16 23:41:58 | Heliyon. 2023 Dec 23; 10(1):e23810 | oa_package/2f/8d/PMC10788286.tar.gz | ||
PMC10788288 | 38226328 | Introduction
Depression is one of the most prevalent mental health problems among young adults (18–25 years of age). ( National Institute of Mental Health, 2022 ) While the prevalence of depression among children is low without any sex differences, notable differences among females and males begin during adolescence an... | Methods
Participants
Our study utilized the United States’ NHANES 2017 to 2020 dataset. The NHANES, conducted by the National Center for Health Statistics (NCHS) on 2-year cycles, assesses health and nutritional status of the United States population. The NHANES constitutes a nationally representative sample of non-ins... | Results
Of the 987 young adults between 18 and 25 years of age, 917 had complete data on iron deficiency and PHQ-9 depressive symptoms and depression. The study sample characteristics and weighted prevalence of PHQ-9 depression by personal characteristics are shown in Table 1 . Of the participants included in our stud... | Discussion
To the best of our knowledge, this is the first study to include three measurements of iron deficiency to examine their associations with young adult depressive symptoms and depression as well as examine sex differences. Our study showed that about 9.5 % of young adults reported at least moderate depression ... | Conclusion
Our study provides evidence that iron deficiency is associated with young adult depression when stratified by sex. Our study findings indicate that young adult females with ferritin deficiency have lower odds of depression while young adult males with ferritin, serum iron, and transferrin deficiencies have h... | Depression is one of the most prevalent mental health conditions throughout the lifespan. Notable differences in the prevalence of depression among females and males arise during adolescence and may peak during young adulthood. Since iron deficiency is a treatable condition that may contribute to depression, this topic... | Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. | Supplementary data
The following are the Supplementary data to this article:
Data availability
I have shared the link to the NHANES dataset.
Acknowledgements
This work was supported by the 10.13039/100000002 National Institutes of Health 10.13039/100000056 National Institute of Nursing Research, United States [5K01... | CC BY | no | 2024-01-16 23:41:58 | Prev Med Rep. 2023 Dec 12; 37:102549 | oa_package/16/bb/PMC10788288.tar.gz |
PMC10788296 | 38104652 | Introduction
Human skeletal muscle differentiates into two major fiber types based on their myosin heavy chain content, each with highly specialized contractile and metabolic profiles. Slow-twitch type I fibers have a slow peak shortening velocity, a low recruitment threshold, and a reliance on oxidative metabolism due... | Methods
Ethics statement
This study was conducted in accordance with the declaration of Helsinki. The study was approved by the regional ethics committee in Stockholm (Dnr: 2017/2034-31/2 and Dnr: 2021-00364). All participants were volunteers who gave their written and oral consent prior to enrolment.
Participant chara... | Results
Total- and intrinsic mitochondrial respiratory capacity in human skeletal muscle fiber types
Previous investigations on mitochondrial respiratory properties in the different muscle fiber types have all used various animal models comparing muscle predominantly expressing oxidative or glycolytic fibers [ 3 , 24 ]... | Discussion
Here we employed a novel technique to measure human muscle fiber type specific mitochondrial respiration, coupled with protein expression analysis of key proteins regulating mitochondrial form and function, to gain insight into mitochondrial specialization in human slow- and fast-twitch muscle fibers. We obs... | Filip J. Larsen and William Apró contributed equally to this work.
Objective
Human skeletal muscle consists of a mixture of slow- and fast-twitch fibers with distinct capacities for contraction mechanics, fermentation, and oxidative phosphorylation. While the divergence in mitochondrial volume favoring slow-twitch fib... | Limitations of the study
A limitation of the current study is the use of western blot methodology to indirectly assess mitochondrial content. Despite extensive efforts to make this method quantitative, we fully acknowledge that the magnitude of difference in mitochondrial content, as assessed here, is unusually large. ... | Supplementary data
The following are the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgments
No acknowledgements. | CC BY | no | 2024-01-16 23:41:58 | Mol Metab. 2023 Dec 15; 79:101854 | oa_package/63/4b/PMC10788296.tar.gz | |
PMC10788298 | 38226340 | This story reflects a personal narrative of a graduate student who experienced a disturbing incident during Mardi Gras in New Orleans, shedding light on the enduring issue of racism. The author's journey to graduate school and the challenges faced along the way provide context for the pivotal moment of racial discrimin... | I was marched around the corner and asked for my identification in front of a small bus. The bus looked like one of the very short public transport vehicles. It was dark. Minimal illumination from the nearby streetlight reached the spot where we were standing. The officer looked at my identification, handed it back, an... | Acknowledgments
I would like to thank Arina Bokas for allowing me to bounce these ideas off of her as I put them to paper. | CC BY | no | 2024-01-16 23:41:58 | Res Pract Thromb Haemost. 2023 Nov 30; 8(1):102288 | oa_package/58/2f/PMC10788298.tar.gz | |||||
PMC10788300 | 38225954 | Introduction
The long-term impact of natural disasters on self-harm and suicidal behaviour in adolescents are unclear, with varied responses to a range of natural hazards around the globe. For example, studies examining the impacts of earthquakes in Japan have reported an increased risk of children and adolescents’ sui... | Methods
Study design and participants
LSAC, also known as Growing Up in Australia , is a longitudinal cohort study of Australian children that began in 2004 ( Edwards, 2014 ). Written informed consent was provided by parents at the Wave 1 interview and this was provided by young people at 14–15 years as well. In this ... | Results
Given that consecutive disaster measures incorporate disaster exposures from the previous waves, we report on disaster exposure in waves 4 to 8. Table 1 shows that on average, 5% of children were directly affected by fire or floods and a further 5% were exposed to drought from wave 4 to 8. However, Fig. 1 s... | Discussion
In this study we find that sudden onset disasters were associated with increased self-harm ideation, self-harm and suicidal ideation of adolescents. Fire or floods in the last year increased the risk of self-harm, self-harm ideation and suicidal thoughts of adolescents. Exposure to some types of multiple dis... | Conclusions
The 2019–20 wildfires attracted world attention (author et al., 2020) and highlighted that Australia has a high risk of disaster exposure. However, the 2023 wildfires in North America underscore that our findings are increasingly applicable to other countries. Beyond wildfires, the IPCC predicts that there ... | Few studies have examined the relationship between exposure to natural hazards and suicide and self-harm in youth. We extend prior research by investigating the association between multiple disasters and the risks of self-harm and suicide longitudinally in a nationally representative longitudinal cohort of adolescents ... | Funding source
This research was supported by the Australian Medical Research Future Fund (MRF1201355). The funders had no influence on the research in this paper.
Competing interests
The authors declare that they have no competing interest.
Ethical statement
The Australian Institute of Family Studies Ethics Committe... | Supplementary data
The following is the Supplementary data to this article.
Data availability
LSAC data is available from the Australian Data Archives | CC BY | no | 2024-01-16 23:41:58 | SSM Popul Health. 2023 Dec 9; 25:101576 | oa_package/ba/d5/PMC10788300.tar.gz |
PMC10788301 | 38150745 | Introduction
There are at least 5 million people currently living with age-related dementia in the United States, posing a major public health problem. Alzheimer’s disease (AD) is the most common form of dementia, accounting for about 70 % of all dementia cases in the elderly (Alzheimer's Association, 2016 ). AD care ... | Methods
Participants
Participants were enrolled in longitudinal studies of memory and aging at Knight ADRC at Washington University in St. Louis. Data was obtained through the Open Access Series of Imaging Studies (OASIS; https://www.oasis-brains.org ) ( Marcus et al., 2010 ). Individuals were excluded from analyses i... | Results
Demographic characteristics of the participants at baseline are presented in Table 1 . There were 153 participants in the study cohort, with an average age of 69.9 ± 5.9 years and average years of education of 15.5 ± 2.5. Of the 153 participants, 87 (56.8 %) identified as female and 52 (34 %) were APOE ε4 ca... | Discussion
We aimed to investigate the relationship between Aβ and cognition in the preclinical and early impairment stages of AD. More specifically, we compared the utility of a single baseline measure of Aβ versus longitudinal measures of Aβ for predicting cognitive decline, as defined by a cognitive composite score.... | The use of biomarkers for the early detection of Alzheimer’s disease (AD) is crucial for developing potential therapeutic treatments. Positron Emission Tomography (PET) is a well-established tool used to detect β-amyloid (Aβ) plaques in the brain. Previous studies have shown that cross-sectional biomarkers can predict ... | CRediT authorship contribution statement
Gengsheng Chen: . Nicole S. McKay: Writing – review & editing. Brian A. Gordon: Conceptualization, Methodology, Writing – review & editing. Jingxia Liu: Methodology, Writing – review & editing. Nelly Joseph-Mathurin: Writing – review & editing. Suzanne E. Schindler: W... | Further reading
Supplementary data
The following are the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgments
This study was supported by NIH P50AG00561, P30NS09857781, P01AG026276, UL1TR002345, P01AG003991, R01AG043434, UL1TR000448 and R01EB009352. Freesurfer ... | CC BY | no | 2024-01-16 23:41:58 | Neuroimage Clin. 2023 Dec 15; 41:103551 | oa_package/3c/a4/PMC10788301.tar.gz | |
PMC10788305 | 38150746 | Introduction
Brain structure and function undergo drastic transformations over the first two decades of life ( Stiles & Jernigan, 2010 ). Over the same period, there are also profound changes in multiple facets of sleep, potentially reflecting developmental programs of brain reorganization ( Knoop et al., 2021 ). Given... | Methods
Participants
We primarily used PSG data from two pediatric samples – the Nationwide Children’s Hospital Sleep DataBank (NCH) and the Child Adenotonsillectomy Trial (CHAT) – both available via the National Sleep Research Resource ( http://sleepdata.org ). The NCH sample was created to facilitate pediatric sleep ... | Results
The primary discovery dataset comprised 2,800 individuals with whole-night PSGs from the Nationwide Children’s Hospital (NCH) Sleep Databank (accessed via the National Sleep Research Resource, NSRR ( Zhang et al., 2018 )). Based on ICD codes, we defined six subsets within the NCH sample based on the presence of... | Discussion
Using both clinical and research datasets, we identified consistent patterns of age-related change during childhood and adolescence, for multiple facets of sleep macro- and micro-architecture. We further showed that, when combined, the different sleep EEG metrics we examined could reliably predict an individ... | Caveats & conclusions
In summary, the present study provides a comprehensive assessment of age-related changes in sleep macro and microarchitecture, based on a large sample from multiple cohorts spanning the first two decades of life. Nonetheless, certain constraints should be mentioned. One obvious limitation is that ... | Highlights
• This study demonstrates the potential of sleep-based features to provide practical markers for tracking neurodevelopment in children across multiple clinical populations. • Using whole-night polysomnography data, we comprehensively describe robust age-related changes in multiple sleep metrics derived from ... | Declaration of competing interest
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Chervin reports the following financial and non-financial potentially competing interests: consultant (through contract with Michigan Medicine) for... | Supplementary data
The following are the Supplementary data to this article:
Data availability
NCH-SDB & CHAT are available via NSRR (http://sleepdata.org). PATS will be posted on NSRR at a future date. Luna software is open and available via http://zzz.bwh.harvard.edu/luna
Acknowledgements
This work was supported by t... | CC BY | no | 2024-01-16 23:41:58 | Neuroimage Clin. 2023 Dec 19; 41:103552 | oa_package/30/1c/PMC10788305.tar.gz |
PMC10788309 | 38226291 | Introduction
Congenital anomalies of the inferior vena cava (IVC) are often recognised as incidental findings at abdominal imaging. Most congenital variations are asymptomatic, but knowledge of these abnormalities can be crucial for preoperative planning of surgeries and endovascular procedures, as well as to avoid mis... | Conclusion
Congenital anomalies of the IVC are often asymptomatic but may have clinical implications. Knowledge of these variations is crucial in preprocedural planning of IVC filter placement or preoperative planning for cardiovascular surgeries as well as nephrectomy. These congenital anomalies may predispose to cert... | The embryology of the inferior vena cava (IVC) is complex, involving the sequential appearance and regression of multiple segments that ultimately form the IVC. Any alteration in this process during embryogenesis can result in congenital anomalies of the IVC. This study aimed to recognise common as well as rare anomali... | Anatomy and embryology
The IVC is the main route of venous return from the lower extremities and abdomen, formed by the confluence of the two common iliac veins at L5. It has a retroperitoneal course in the abdomen, located to the right of aorta. It courses close to the liver where it receives the hepatic veins and the... | Acknowledgements
Competing interests
The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.
Authors’ contributions
R.K.C. performed the manuscript preparation, literature review, and editing. P.N. conceptualised the idea, and perf... | CC BY | no | 2024-01-16 23:41:58 | SA J Radiol. 2023 Nov 24; 27(1):2687 | oa_package/62/b9/PMC10788309.tar.gz | |||
PMC10788311 | 38225986 | Introduction
Glucagon‐like peptide (GLP)‐1 agonist therapy is a non‐insulin‐based approach that is combined with diet and exercise to treat type 2 diabetes mellitus and obesity. It has gained recognition as an effective weight loss treatment with only mild side effects. The most notable are nausea, vomiting and diarrho... | Discussion
Semaglutide is a GLP‐1 receptor agonist that was first marketed over 15 years ago, initially designed for glycaemic control in diabetic patients. By mimicking the GLP‐1 hormone released by the gut in response to food, semaglutide increases endogenous insulin secretion to lower blood glucose. The 2021 STEP 2 ... | Summary
Semaglutide is a new weight loss treatment that has received substantial media attention in recent years. Anaesthetists must be aware of a potentially dangerous side effect of the drug: decreased gastric emptying. This is caused by effects on gastric smooth muscle, mediated by the vagal afferent nerves. This is... | Report
Case 1
A 70‐year‐old man with a body mass index (BMI) of 35 kg.m −2 and a medical history of ischaemic heart disease, type 2 diabetes mellitus, hypertension and chronic obstructive pulmonary disease presented for elective endoscopic retrograde cholangiopancreatography due to cholidocholelithiasis. His medicatio... | Acknowledgements
This case report was published with the written consent of the two patients involved. There are no competing interests to declare. | CC BY | no | 2024-01-16 23:41:58 | Anaesth Rep. 2024 Jan 14; 12(1):e12278 | oa_package/cd/c0/PMC10788311.tar.gz | |||
PMC10788312 | 38226344 | INTRODUCTION
Animals sometimes possess ornamentation that seem to have negative effects on survivorship, such as long tails and colorful plumage in birds (Andersson, 1994 ). Many empirical studies have shown sexual selection for ornaments, explaining the evolution of seemingly costly ornaments (e.g., see Hill & McGraw... | MATERIALS AND METHODS
Experimental setup
I used four commercially available “chuonchuon” for my experiment (ca. 7 cm length: Tirakita, Japan). I used unmanipulated chuonchuon as an ancestral state, in which neither sexually selected ornamentation nor compensatory traits have yet been evolved. Then, I used a plastic str... | RESULTS
Toy model
I found a significant quadratic relationship between tail length manipulation and stability of the chuonchuon (Table 1 ; Figure 2 lower panel): The stability of the chuonchuon, measured as an absolute angle deviated from the horizontal plane, increased with decreasing tail length until the peak val... | DISCUSSION
The main finding from the chuonchuon experiment is that the apparent concave cost function can evolve purely through sexual selection in the presence of compensatory traits (i.e., with no viability advantage of ornamentation), which is further reinforced by a mathematical model. The importance of compensator... | Abstract
The cost of ornamentation is often measured experimentally to study the relative importance of sexual and viability selection for ornamentation, but these experiments can lead to a misleading conclusion when compensatory trait is ignored. For example, a classic experiment on the outermost tail feathers in the ... | AUTHOR CONTRIBUTIONS
Masaru Hasegawa: Conceptualization (lead); formal analysis (lead); funding acquisition (lead); methodology (lead); writing – original draft (lead).
CONFLICT OF INTEREST STATEMENT
The author declares no conflict of interest.
Supporting information | ACKNOWLEDGMENTS
I thank Dr. Emi Arai, Dr. Shumpei Kitamura and his lab members at Ishikawa Prefectural University for their kindest advices and supports. I also thank Prof. Michael D. Jennions, reviewers, and English‐proofing Company (Enago) for their helpful comments. MH was supported by the KAKENHI grant of the Japan... | CC BY | no | 2024-01-16 23:41:58 | Ecol Evol. 2024 Jan 14; 14(1):e10850 | oa_package/9c/3b/PMC10788312.tar.gz | |
PMC10788314 | 38226113 | Introduction
A preventable blindness condition is a refractive error (RE). According to the World Health Organization (WHO), in 2006, approximately 153 million people over the age of five worldwide suffer from uncorrected refractive abnormalities; eight million of these people are blind [ 1 ]. Furthermore, 12.8 million... | Materials and methods
A descriptive questionnaire-based cross-sectional study was carried out during the period from December 2022 to November 2023 in Bisha province, southwest Saudi Arabia. All the governmental schools in the province were involved in a computer list that the Ministry of Education accessed; then, we u... | Results
A total of 360 schoolchildren from primary schools were enrolled in the study. The age of the participants ranged from seven to 14 years, with a mean of 10.1 years (standard deviation (SD)=2.05). Most of the participants were boys (59.4%, n=214). About half of the participants are in age equal to or more than 1... | Discussion
In this study, the prevalence of REs among schoolchildren in Bisha, Saudi Arabia, between the ages of seven and 14 years, was compared to reports from other parts of the world. Understanding that RE is a complicated and multidimensional condition with a wide range of genetic, demographic (age, race, ethnicit... | Conclusions
The prevalence of REs among school-age children in Bisha, Saudi Arabia, was presented in the current study. The study results showed that half of the sample population in this area had at least some REs. According to the study's findings, about half of the participants in this research had some degree of RE... | Background: A widespread and serious eye condition is a refractive error (RE). Globally, uncorrected refractive defects affect numerous individuals, with some who are blind. Numerous studies in Saudi Arabia have been conducted to assess reflective error. However, there is a lack of knowledge regarding RE among school-a... | CC BY | no | 2024-01-16 23:41:58 | Cureus.; 15(12):e50530 | oa_package/bd/62/PMC10788314.tar.gz | ||
PMC10788315 | 38226093 | Introduction
The infratemporal fossa, situated immediately medial to the mandibular ramus, serves as a central hub for the distribution of the mandibular division of the trigeminal nerve. The four main branches of the mandibular nerve are lingual, inferior alveolar, long buccal, and auriculotemporal nerves, with the la... | Discussion
The prevalence of neural communications between the auriculotemporal and inferior alveolar nerves varies in the literature, likely owing to the incidental nature of this observation and the limited number of specimens examined. Anecdotally, we have rarely observed this anastomosis during infratemporal dissec... | Conclusions
Occasional neural communications exist between the branches of the mandibular nerve within the infratemporal fossa. The functional significance of these interconnections is yet to be fully understood. In this report, we illustrate neural communication between the auriculotemporal and inferior alveolar nerve... | Communications between cranial nerves or their branches have been described previously. The exact functional significance of some of these neural communications remains to be fully understood. This paper reports a unique communication between the auriculotemporal and inferior alveolar nerves within the infratemporal fo... | Case presentation
During dissection of the infratemporal fossa in a formalin-fixed, latex-injected, adult head specimen, a neural communication was found between the auriculotemporal and inferior alveolar nerves. Briefly, after the removal of the masseter muscle and outer cortex of the mandible, the inferior alveolar n... | The dissection was carried out by MMS and RST. TT, MMS, and RST conducted the literature review and drafted the manuscript. All authors reviewed and approved the final manuscript. The authors are grateful to Dr. Thomas Müller for providing them with a copy of his elegant article. Artificial intelligence (AI) (GPT 3.5)... | CC BY | no | 2024-01-16 23:41:58 | Cureus.; 15(12):e50526 | oa_package/8d/81/PMC10788315.tar.gz | ||
PMC10788316 | 38226096 | Introduction
Surgical training in the United Kingdom typically comprises two distinct programs: two years of core surgical training (CST), followed by six years of specialist training (ST) as a speciality registrar [ 1 ]. During CST, junior surgical trainees () undergo placement in several different, but usually comple... | Materials and methods
A retrospective analysis of the Intercollegiate Surgical Curriculum Program (ISCP) eLogbook was performed. The inclusion criteria were all operations performed by one vascular surgery-themed trainee within a regional vascular hub between August 3, 2022, and January 31, 2023, and all operations per... | Results
The trainee conducted a total of 229 cases overall. One hundred twenty cases were performed in the first six-month block as a CST year one, and 109 cases in the second six-month block as a CST-R. Within the first six-month block, 89.5 days were spent in the hospital with the potential to operate, and, in the se... | Discussion
There is a clear trend evident in the results. As a CST-R, the trainee had played a more significant role in a greater number of cases. The number of cases where they were operating independently (STU, P, or T) went from 13% to 26% of the total cases performed within the six-month block, a statistically sign... | Conclusions
Acting up can be an invaluable way for core surgical trainees to develop their operative and nonoperative skills. It provides greater independence and endorses the development of clinical reasoning and decision-making. It enables the CST to practice their leadership skills and more senior-level communicatio... | Introduction
United Kingdom surgical training consists of a two-year core surgical training (CST) followed by a six-year higher speciality training (ST). There is a significant step up in responsibility and operative skills when transitioning from core to higher training. One-way trainees can bridge this gap is to “act... | CC BY | no | 2024-01-16 23:41:58 | Cureus.; 15(12):e50517 | oa_package/34/da/PMC10788316.tar.gz | ||
PMC10788317 | 38226087 | Introduction
Osteochondromas are the most common type of benign bone tumor, accounting for 35% to 40% of all benign bone tumors [ 1 ]. However, their occurrence in nonstandard locations and association with developmental deformities present unique challenges in diagnosis and management [ 1 ]. This report details an unc... | Discussion
The presented case of ulnar exostosis with a developmental forearm deformity in a 15-year-old female patient raises several important considerations in the field of pediatric orthopedics. The occurrence of exostosis in the ulna, combined with a history of trauma and a subsequent supracondylar humerus fractur... | Conclusions
This case highlights the significance of considering unusual etiologies, such as exostoses, in the differential diagnosis of forearm swellings, particularly in the context of a relevant medical history. The radiographic and CT findings were crucial in establishing a precise diagnosis and guiding the appropr... | This case report presents a rare occurrence of exostosis of the ulna associated with a developmental deformity of the left forearm in a 15-year-old female. The patient reported a history of trauma resulting in a supracondylar humerus fracture managed conservatively eight years prior. The patient presented with a two-ye... | Case presentation
A 15-year-old female sought evaluation at the orthopedic outpatient clinic, reporting a two-year duration of pain and swelling in her left forearm. The patient recounted a traumatic incident from eight years prior, resulting in a supracondylar humerus fracture. The fracture had been treated with an ab... | CC BY | no | 2024-01-16 23:41:58 | Cureus.; 15(12):e50528 | oa_package/5c/56/PMC10788317.tar.gz | |||
PMC10788318 | 38221544 | Introduction
Technological advances in the orthodontic practice led clear aligner treatment (CAT) meet the demand for a minimally visible and customized treatment modality; however, it is still one of the main topics of scientific research of how to maximize treatment efficiency [ 1 , 2 ]. Orthodontic treatment withou... | Materials and methods
This prospective clinical study was approved by ...Başkent University Institutional Review Board and Ethics Committee (Project no: D-KA 21/13) and supported by ...Başkent University Research Fund. Inclusion criteria were (1) patients receiving Lite, Moderate or Comprehensive Invisalign® treatmen... | Results
A total of 42 patients and 417 teeth were included in the data analysis. The ICC value calculated for the reliability of the arch length-tooth size discrepancy table of the ClinCheckTM software was found to be 0.996 with good repeatability. The mean difference between T0 and T1 readings was − 0.09 mm (median, −... | Discussion
IPR is an essential component of CAT which creates room for teeth to perform digitally planned movements and has to be executed precisely in order to achieve the desired outcome. Therefore, the primary aim of this study was to investigate the consistency between planned and executed IPR for 3 IPR methods inc... | Conclusions
The overall results of this in vivo study showed a discrepancy between planned and executed IPR with the hand-operated abrasive strip system, tending to produce less enamel reduction than planned. The hand-operated abrasive strips fell short to fully realize the planned amount of IPR, especially on the ma... | Objectives
To comparatively assess 3 interproximal reduction (IPR) methods used in clear aligner treatment with regard to accuracy, and patient perception of discomfort and anxiety.
Materials and methods
A total of 42 patients, treated with the Invisalign® system, were included in this prospective trial and received on... | Limitations
Although the arch length-tooth size discrepancy table of the ClinCheckTM software is claimed to be prone to measurement errors, its repeatability was found to be very good which shows that the quantitative uncertainty was very low. There is some margin of error in all measurement methods (manual or digital)... | Author contribution
P.G.E. contributed to the concept of this study, determined the methodology, explored the sources, performed the data curation and wrote the original text. A.A.Ö., A.A.K., and N.İ.T. contributed to the concept design of this study, determined the methodology, reviewed and edited the original text,... | CC BY | no | 2024-01-16 23:41:58 | Clin Oral Investig. 2024 Jan 15; 28(1):95 | oa_package/94/b9/PMC10788318.tar.gz |
PMC10788319 | 0 | Introduction
Over the past decades, scholars have dissected the manifold challenges of Artificial Intelligence (AI) in the health sector [ 1 , 2 ]. The attention has been often drawn to possible misuses or overuses of technology that entail problems of privacy and security, fairness and equity, data quality and data a... | Conclusions
This paper has mostly explored terra incognita, examining the underuse of AI for health, what it means and how much it may cost. Attention was drawn to the relevance of an issue that the European Parliament has presented as a ‘major threat’ in 2020. Scholars have increasingly debated the crucial role that A... | Purpose
This contribution explores the underuse of artificial intelligence (AI) in the health sector, what this means for practice, and how much the underuse can cost. Attention is drawn to the relevance of an issue that the European Parliament has outlined as a "major threat" in 2020. At its heart is the risk that res... | The theory of technological uses
In its common sense, underuse corresponds to using less than what might be expected of a resource or technology. Non-use is considered a quasi-synonym of the term. In the field of technology use theory, the underuse of AI is directly linked to the notions of adoption, use and appropriat... | Funding
Open access funding provided by Medical University of Graz. Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 520382567. Parts of this work have also received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 826078 (Featur... | CC BY | no | 2024-01-16 23:41:58 | Health Technol (Berl). 2024 Dec 12; 14(1):1-14 | oa_package/d1/71/PMC10788319.tar.gz | |||
PMC10788320 | 37991561 | Introduction
CVD is one of the leading causes of death and morbidity worldwide accounting for 34% (20.2 million) of deaths in 2022 with an estimated 500 million active cases [ 1 ]. CVD is associated with increased levels of inflammation, especially in the vascular endothelium. This inflammation may contribute to the pr... | Materials and methods
Study population
30 Plasma samples from patients (16 female; 14 male) with an average age of 65 ± 22 with CVD were selected and purchased from the BioIVT biobank along with 30 age and sex matched healthy controls with an average age of 60 ± 13. Samples were chosen from volunteers that had one or m... | Results
In this study, the suitability of both Neu5Ac and Neu5,9Ac 2 as novel diagnostic markers of CVD was investigated. The DMB assay employed for the analysis of Neu5Ac and Neu5,9Ac 2 exhibited low levels of inter and intra-assay variation (< 10%). Neu5Ac and Neu5,9Ac 2 were detected in each sample (Fig. 2 ). Th... | Discussion
Inflammation is a component of CVD that can result in myocardial and endothelial damage [ 32 , 33 ]. An increase in inflammation related to CVD can lead to an acute-phase response which is characterised by upregulation of specific proteins such as alpha-1-acid glycoprotein, alpha-1-antitrypsin, fibrinogen, ... | Conclusions
Neu5Ac and Neu5,9Ac 2 concentrations were determined in samples from 30 healthy controls and 30 patients with diagnosed CVD. Neu5,9Ac 2 could be detected and quantified with high precision even when present in very small quantities compared to Neu5Ac. Statistically significant elevations of concentrations... | Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The presence of CVD is characterised by high levels of inflammation which have previously been associated with increased plasma concentrations of N -acetyl neuraminic acid... | Electronic supplementary material
Below is the link to the electronic supplementary material.
| Author contributions
D.I.R.S, G.K and H.M.I.O designed the study, won funding for the programme, and supervised the study. J.C. and D.T. carried out the selection of samples with the assistance of M.M., G.K., D.I.R.S. and H.M.I.O. D.T. and M.M. were responsible for the ordering and initial processing of purchased sampl... | CC BY | no | 2024-01-16 23:41:58 | Glycoconj J. 2023 Nov 22; 40(6):645-654 | oa_package/2c/14/PMC10788320.tar.gz |
PMC10788321 | 38221600 | Introduction
The cantilever fixed partial denture (CFPD) has been defined as a fixed restoration that has one or more abutments at one end, with the other end unsupported [ 1 ]. In principle, CFPDs can replace any tooth in the dental arch, but are considered particularly useful for avoiding a removable partial denture ... | Material and methods
CFPDs were designed to replace a lower first molar by means of a distal cantilever in the shape of a premolar (mesio-distal dimension: 8 mm) retained by 2 splinted complete crowns attached to the first and second premolar. A mandibular typodont (type ANA-4, Frasaco, Tettnang, Germany) was used as t... | Results
Test forces corresponding with failure and initial damage are listed in Table 2 and shown in Fig. 5 .
Failure load
Mean test forces at failure ranged between 392 N for axially loaded partially veneered zirconia CFPDs on natural teeth and 1181 N for axially loaded monolithic zirconia CFPDs on CoCr abutment t... | Discussion
This study tested the hypothesis that there would be no differences between the loads at failure and initial damage between three-unit CFPDs for the replacement of a premolar-size tooth as a function of restoration design (monolithic/partially veneered/completely veneered zirconia or completely veneered CoCr... | Conclusions
Monolithic zirconia CFPDs may be considered a viable alternative to completely veneered metal-ceramic CFPDs with CoCr frameworks in terms of fracture load.
Oblique loading of the cantilever pontic drastically reduced the fracture load of monolithic zirconia CFPDs and should therefore be avoided in a clinica... | Objectives
The aim of this study was to compare failure load and initial damage in monolithic, partially veneered, and completely veneered (translucent) zirconia cantilevered fixed partial dentures (CFPDs), as well as completely veneered metal-ceramic CFPDs under different support and loading configurations.
Materials ... | Acknowledgements
The authors would like to thank the company 3M Oral Care for providing the ceramic materials and the adhesive luting cement used in this study and Mr. Robert Schnagl (3M Oral Care) for the scanning electron microscopic fracture analysis. We would also like to thank Mr. Philipp Doebert (3M Oral Care), w... | CC BY | no | 2024-01-16 23:41:59 | Clin Oral Investig. 2024 Jan 15; 28(1):94 | oa_package/ab/e2/PMC10788321.tar.gz | |
PMC10788322 | 38221585 | Introduction
Climatic change is a continuous process that has happened since the first stable global climate system was formed and the first living place on Earth was developed (IPCC, 2013 ). Governments have agreed to move towards better sustainability through the Paris climate change agreement and the 2030 Agenda fo... | Results
AHP model results
According to the research parameters, weights were allocated to various indicators based on experts’ assessments. They were computed for each of the three parameters’ indicators. A consistency check is required since weights are only valid if they are acquired from consistent or close consiste... | Discussion
According to Table 4 , Scenario 2 has the highest risky areas compared to scenario 1, estimated at 1.12 km 2 . This scenario considers the actual weights of the indicators based on experts’ judgments. Because of the variable nature of indicators, it is impossible to balance the relative weights of all varia... | Conclusions
Spatial vulnerability maps due to climate change impacts for Al Alamein New City have been generated according to the developed decision-making framework. The proposed framework overcomes the problem of recognizing the destructive consequences of climate change on coastal communities due to its ability to e... | The world is currently confronting one of its biggest environmental challenges: combating climate change. Coastal zones are one of the areas thought to be most sensitive to current and future climate change threats. The paper integrates Remote Sensing (RS), Geographic Information System (GIS) techniques, and Multi-Crit... | Literature review
Several research efforts have been devoted to assessing coastal vulnerability to climate change impacts using different methodologies. Satta ( 2014 ) established an Index-based method for the integrated analysis of coastal risk to multiple hazards that considers the impacts of SLR, storm variability, ... | Appendix 1
Table 5 .
Appendix 2
Table 6 .
Author contribution
Conceptualization: Mohamed Marzouk and Shimaa Azab; Methodology: Mohamed Marzouk and Shimaa Azab; Validation: Mohamed Marzouk and Shimaa Azab; Formal analysis: Shimaa Azab; Investigation: Shimaa Azab; Writing—original draft preparation: Shimaa Azab; Writin... | CC BY | no | 2024-01-16 23:41:59 | Environ Monit Assess. 2024 Jan 15; 196(2):147 | oa_package/69/e1/PMC10788322.tar.gz | |
PMC10788323 | 0 | Introduction
The simultaneous capture of two bound atomic electrons followed by the emission of two neutrinos plus X-rays or Auger electrons, known as two-neutrino double-electron capture (2 ECEC), is a nuclear process allowed in the Standard Model. Compared to the two-neutrino double-beta ( ) decay, the simultaneous e... | Analysis methods
The energy region used to set a limit on the half-life of 0 ECEC of Ar is defined between 410 and 450 keV (±20 keV around the energy of 429.88 keV, as indicated by the orange band in Fig. 1 ). Given the high statistics in this energy region, data are used in a binned form, with a 1 keV binning. It ... | Results
The best fit, defined as the minimum of the profiled likelihood ratio, yields = 0, i.e. we do not observe any signal events from 0 ECEC. Data from the five Gerda Phase II analysis data sets and in the energy region of the analysis are shown in Fig. 4 together with the best-fit model and the residuals norm... | Conclusions
In this work, we searched for the 429.88 keV line from the Ar 0 ECEC using the final total exposure of the Gerda Phase II experiment, combined with the Gerda Phase I exposure. No signal was observed, and a lower limit on the half-life of this process was derived, yielding year (90% CL). This is the... | The GERmanium Detector Array ( Gerda ) experiment operated enriched high-purity germanium detectors in a liquid argon cryostat, which contains 0.33% of Ar, a candidate isotope for the two-neutrino double-electron capture (2 ECEC) and therefore for the neutrinoless double-electron capture (0 ECEC). If detected, this pr... | The GERDA experiment
The Gerda experiment was located at the Laboratori Nazionali del Gran Sasso (LNGS) of INFN, in Italy [ 10 , 18 , 19 ], where a rock overburden of 3500 m water equivalent reduces the flux of cosmic muons by six orders of magnitude [ 10 ]. High-purity germanium (HPGe) detectors, isotopically enri... | Acknowledgements
The Gerda experiment is supported financially by the German Federal Ministry for Education and Research (BMBF), the German Research Foundation (DFG), the Italian Istituto Nazionale di Fisica Nucleare (INFN), the Max Planck Society (MPG), the Polish National Science Centre (NCN, Grant number UMO-2020/... | CC BY | no | 2024-01-16 23:41:59 | Eur Phys J C Part Fields. 2024 Jan 14; 84(1):34 | oa_package/cc/8d/PMC10788323.tar.gz | |
PMC10788324 | 38221592 | Background
Glues are liquid embolics applied in endovascular embolizations since approximately 50 years: first cyanoacrylate application in peripheral bleeding embolizations was described by Dotter in 1975 [ 5 ].
Since then, the role of glue in the embolization field has grown and nowadays, thanks also to imaging and m... | Methods
This is a retrospective analysis of patients with PA treated in five centers from 2020 to 2023.
Electronic radiological and medical records were reviewed.
All patients signed a written informed consent, if clinical conditions allowed. The local ethical committee approved the study.
Inclusion criteria were: PA d... | Results
Sample features
The study sample included 54 patients (19 females, 35 males; mean age: 63.8 years, range 18–91) affected by PAs (Table 1 ).
Lesions etiology was mainly traumatic, in 31 subjects (57.4%), the others being inflammatory (24.1%) or spontaneous (18.5%); 39 (72.2%) were symptomatic, presenting wi... | Discussion
In this retrospective analysis percutaneous glue embolization of PAs was safe and effective; the most common technical approach consisted in a US-fluoroscopic guided puncture using a 22G needle and injecting a 1:1 glue-Lipiodol mixture. PAs were located in thoraco-abdominal districts, both visceral and parie... | Conclusion
In this study, PAs embolization with glue via percutaneous direct puncture was safe and effective with a low rate of minor complications. | Background
This retrospective multicentric study aims to report on technical safety and effectiveness of pseudoaneurysms embolization with glue ( N -butyl cyanoacrylate) adopting a percutaneous direct puncture approach.
Results
Fifty-four patients data were collected from five centers.
All patients at the time of treat... | Abbreviations
Cardiovascular and Interventional Radiology Society of Europe
Computed Tomography
ConeBeam Computed Tomography
Digital subtraction angiography
Gauge
Index Normalized Ratio
Maximum Intensity Projection
Pseudoaneurysm
Post-embolization syndrome
Ultrasound
Acknowledgements
None.
Authors’ contributions
Concep... | CC BY | no | 2024-01-16 23:41:59 | CVIR Endovasc. 2024 Jan 15; 7:11 | oa_package/9e/f4/PMC10788324.tar.gz | |
PMC10788325 | 38221572 | Background
Esophageal epiphrenic diverticulum is a rare disease. The estimated incidence of epiphrenic diverticula is approximately 1:500,000/year [ 1 ]. Esophageal motility disorders, such as achalasia, are often comorbidly associated with epiphrenic diverticula [ 2 ]. Surgery is generally considered to be indicated f... | Discussion
We encountered a rare case of a giant epiphrenic diverticulum associated with gastroesophageal reflux disease. We performed thoracoscopic diverticulectomy and laparoscopic fundoplication for the hiatal hernia and gastroesophageal reflux disease, while avoiding esophagomyotomy due to absence of any evidence o... | Conclusions
In this report, we described a rare case of a large epiphrenic diverticulum with associated reflux esophagitis. A good surgical outcome was achieved by thoracoscopic resection of the diverticulum and laparoscopic Dor fundoplication. | Background
Surgery is indicated for symptomatic epiphrenic esophageal diverticula. Based on the features of a case, thoracoscopic or laparoscopic approaches may be used. Epiphrenic diverticula are often associated with esophageal motility disorders, but cases of reflux esophagitis have rarely been reported. In this rep... | Case presentation
Chief complaints
Eructation and hiccup.
History of present illness
A 69-year-old man was diagnosed with esophageal diverticulum 35 years ago but had been followed up without treatment. Five years ago, he visited a clinic with an exacerbation of his chief complaint. Although he was prescribed esomepraz... | Abbreviations
High-resolution manometry
Squamocolumnar junction
Lower esophageal sphincter
Acknowledgements
The authors used an English Language Service (International Medical Information Center, Tokyo, Japan) for editing the language in the manuscript.
Author contributions
YU and SO have made substantial contributions... | CC BY | no | 2024-01-16 23:41:59 | Surg Case Rep. 2024 Jan 15; 10:17 | oa_package/19/40/PMC10788325.tar.gz | ||
PMC10788326 | 38219249 | Introduction
Audiological disorders, including deafness and tinnitus, represent significant challenges to individuals and healthcare systems worldwide [ 1 ]. These conditions can lead to profound and often debilitating consequences, affecting auditory perception and overall quality of life. Deafness, complete loss of h... | Proposed research methodology
Data insights
The multi-layer brain network dataset was collected by Sun Yat-sen University [ 41 ]. The dataset includes three distinct groups, consisting of 51 deaf cases, 54 with tinnitus, and 42 healthy individuals. The study thoroughly analyzed their respective brain network function.
... | Experimental findings and results
In audiology, it can be challenging to differentiate individuals who suffer from hearing loss or tinnitus from normal cases. It demands careful identification and comprehensive analysis, which cannot be underestimated. Patients suffering from auditory disorders experience a significant... | Proposed study findings and discussion
To accurately diagnose auditory disorders, evaluating the effectiveness of different methodologies is essential. Recent advancements in this field have the potential to significantly improve diagnostic and therapeutic approaches, ultimately leading to better patient care. Pei-Zhen... | Conclusion and future scope
The main aim of this study is to address the essential challenges associated with differentiating individuals with hearing impairments, such as deafness and tinnitus, from those with normal hearing. The study has contributed significantly to the field by presenting an improved approach for a... | In the field of audiology, achieving accurate discrimination of auditory impairments remains a formidable challenge. Conditions such as deafness and tinnitus exert a substantial impact on patients’ overall quality of life, emphasizing the urgent need for precise and efficient classification methods. This study introduc... | Related work
In recent years, the intersection of audiology, neuroimaging, and machine learning has prompted various investigations to advance the understanding and diagnosis of auditory disorders. A survey of relevant literature reveals several pertinent studies that contribute to developing similar methodologies.
Che... | Acknowledgements
We appreciate the editorial board and reviewers feedback.
Author contributions
M.A. directed the research and planned the hypothesis as the corresponding author. M.A. and Y.A. meticulously conducted the experiments and produced the figures. Both authors actively contributed to the composition and editi... | CC BY | no | 2024-01-16 23:41:59 | Brain Inform. 2024 Jan 14; 11(1):3 | oa_package/ce/cd/PMC10788326.tar.gz |
PMC10788327 | 38219269 | Background
Physical activity (PA) is described as 'any body movement produced by skeletal muscles that requires energy expenditure', including activities performed at work, play, housework, travel, and recreation [ 1 ]. It provides health benefits, including prevention and treatment of many conditions such as osteoarth... | Methods
We conducted an umbrella review of SRs in accordance with the Cochrane Handbook’s chapter on overviews of reviews and the Joanna Briggs Institute Manual for Evidence Synthesis [ 15 , 16 ]. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [ 17 ] for the flow chart and ... | Results
Study Inclusion
The search identified 278 publications from databases, 3426 from registers, and 15 through other sources. Of the 85 SRs screened by the full text, 34 were excluded (Additional file 1 : Supplemental File 5) and 51 SRs [ 11 , 13 , 34 – 81 ] were included (Fig. 2 ).
Characteristics of Studies I... | Discussion
Main Findings
Overall, our results were consistent across different PA outcomes (steps per day, MVPA, and PA as composite outcome) in almost all the SRs, while few discordances in SB were found. With low to moderate CoE and ‘possible to definitive clinical relevance’, using WDs may increase PA by a median of... | Conclusions
Our results indicate that the adoption of WDs represents a beneficial approach to enhance physical activity across diverse population groups, although there is some level of uncertainty, particularly in the subgroups of individuals with pathologies and older adults, as well as in the case of sedentary behav... | Background
Several systematic reviews (SRs), with and without meta-analyses, have investigated the use of wearable devices to improve physical activity, and there is a need for frequent and updated syntheses on the topic.
Objective
We aimed to evaluate whether using wearable devices increased physical activity and redu... | Eligibility Criteria
Types of Interventions
We included systematic reviews that investigated the use of WDs to improve PA levels. WDs included devices such as accelerometers, pedometers, Electronic Activity Monitor Systems (EAMSs), or global positioning systems (GPS). We included the use of WDs when it was the only com... | Abbreviations
Assessment of multiple systematic reviews, version 2
Corrected covered area
Certainty of evidence
Chronic obstructive pulmonary disease
Database of abstracts of reviews of effects
Electronic activity monitor systems
Global positioning system
Grading of recommendations, assessment, development, and evaluat... | CC BY | no | 2024-01-16 23:41:59 | Sports Med Open. 2024 Jan 14; 10:9 | oa_package/c9/04/PMC10788327.tar.gz |
PMC10788328 | 38221549 | Background
Nowadays, clear aligners (CAs) have gained widespread acceptance for treating malocclusion due to their aesthetic and comfortable features [ 1 , 2 ]. However, long-distance space closure in cases of premolar extraction with aligners can be challenging for orthodontists, owing to the occurrence of the “rolle... | Materials and methods
Finite element model study
A healthy adult with well-aligned complete dentition was selected as the subject for this study. Based on cone-beam computed tomography (CBCT) data, the three-dimensional model of alveolar bone and the maxillary dentition with the extraction of the first premolars were r... | Results
F, M and d in the mesial-distal direction of the maxillary dentition
During the retraction of anterior teeth, all F and M values of different directions recorded by both methods were reported in the supplementary information (Additional file 1 : 3–6). When closing the extraction space of the first premolar, th... | Discussion
Anchorage control is critical for extracted patients with incisor protrusion or severe crowding. Loss of anchorage can be disastrous in these cases where strong anchorage is needed, so reinforcing anchorage of posterior teeth should be carried out throughout the orthodontic process. Our study proposed a new ... | Conclusions
Our study, by both the FE model and the experimental model, indicated that the biomechanics of the clear aligner during space closure was optimized by locally thickening the posterior segment of the aligner to form the enhanced structure. The enhanced structure resulted in a decrease in the force magnitude ... | Background
Mesial tipping of posterior teeth occurs frequently during space closure with clear aligners (CAs). In this study, we proposed a new modification of CA by localized thickening of the aligner to form the enhanced structure and investigate its biomechanical effect during anterior retraction.
Methods
Two method... | Limitations
Although finite element analysis is one of the best ways to analyze biomechanics delivered by orthodontic appliances, it still has its limitations in accurately simulating the true oral environment (like body temperature and saliva), and it cannot simulate the continuous application of orthodontic forces. M... | Abbreviations
Clear aligner
Center of resistance
Cone-beam computed tomography
Periodontal ligament
Finite element
Local coordinate system
Force
Moment
Distance
Acknowledgements
We thank Lei Huang and Xianbo Xu for their assistance with this study.
Author contributions
XJ and XT contributed to methodology, data curatio... | CC BY | no | 2024-01-16 23:41:59 | Prog Orthod. 2024 Jan 15; 25:3 | oa_package/f3/c7/PMC10788328.tar.gz |
PMC10788329 | 38225950 | Introduction
Rice is one of the important staple crops globally, and hybrid rice technology has greatly increased rice production, ensuring global food security. Along with the progression of society and the enhancement of living standards, there has been a gradual increase in the demand for rice quality (Li et al. 20... | Materials and methods
Plant materials and field experiments
In this study, a total of 141 hybrid rice combinations were obtained by crossing 7 TGMS lines with 25 restorer lines. The TGMS lines include Jing4155S (J4155S), LongZhen36S (LZ36S), HuaYue468S (HY468S), ZhenXiangS (ZXS), HuaXuan302S (HX302S), LongKe638S (LK638... | Results
Effect of sowing date and meteorological factors on quality of hybrid rice
The rice quality traits of the hybrids collected from 5 trial locations, with multiple intermittent sowing arrangements, were measured, and the distributions of the trait values are illustrated in Fig. 1 a and Supplementary Table S4 . ... | Discussion
Rice quality is one of the important goals in hybrid rice breeding improvement. The formation of rice grain quality is under genetic control and also influenced by the environment. Numerous studies have been undertaken to explore the impact of sowing dates on rice quality. However, due to differences in loca... | Improving quality is an essential goal of rice breeding and production. However, rice quality is not solely determined by genotype, but is also influenced by the environment. Phenotype plasticity refers to the ability of a given genotype to produce different phenotypes under different environmental conditions, which ca... | Supplementary Information
Below is the link to the electronic supplementary material. | Author contribution
YZY, XML, and KW conceived and designed experiments. RRC, DXL, and JF contributed to data analysis and the first draft of the manuscript. RRC and YJW contributed to data collection. CJF, PQ, XWZ, ZBS, KH, LL, and WZ were in charge of filed management. YZY, XML, and KW supervised and complemented the... | CC BY | no | 2024-01-16 23:41:59 | Mol Breed. 2024 Jan 15; 44(1):4 | oa_package/cc/31/PMC10788329.tar.gz | |
PMC10788330 | 38221524 | Introduction
Developmental deformations of the skull in infants, especially those resulting from premature fusion of cranial sutures, are an area of a multidisciplinary interest 1 , 2 . Skull deformities and associated developmental problems constitute a hallmark of single suture synostoses, from which nonsyndromic sag... | Materials and methods
Study design
This retrospective study was performed on EEG records of patients with NSC treated in our institution between January 2018 and June 2020. The EEG was registered as an element of the diagnostic protocol of NSC in our institution and an informed consent was obtained from legal guardians... | Results
NSC group versus control group in terms of amplitudes and coherence
The amplitude was calculated for all leads. The amplitude values are presented in Table 1 . Significantly lower amplitudes were found in leads O1, O2, P3, P4, T5 and C4 in the group of children with NSC (Table 1 , Fig. 1 ). In terms of inter... | Discussion
Electroencephalography in patients with craniosynostosis provides an interesting information about the brain functioning, even many years after the diagnosis 30 . Nevertheless, EEG is not typically included in the standard diagnosis of premature suture fusion, except in a few cases of syndromic craniosynosto... | Conclusions
Children with NSC have their own unique EEG profile. The differences in relation to normocephalic individuals are visible mainly in the occipital, posterior parietal and posterior temporal regions. NSC patients achieve lower values of amplitudes and intrahemispheric coherence there, but interhemispheric con... | Despite the undertaken treatment, children with nonsyndromic sagittal craniosynostosis (NSC) are burdened with problems with speech development, visuospatial and other cognitive deficits. The electroencephalographic assessment has not influenced the diagnostics and treatment strategy of craniosynostosis so far but the ... | Author contributions
T.S.—Protocol development, Data collection, Data analysis, Figures preparation, Manuscript writing J.S.—Data collection, Manuscript writing Both authors read and approved the final version of the manuscript.
Funding
This publication was prepared without any external source of funding.
Data availabi... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1301 | oa_package/34/ad/PMC10788330.tar.gz | |
PMC10788331 | 38221525 | Autosomal dominant episodic ataxia type 2 (EA2) is caused by variants in CACNA1A . We examined a 20-year-old male with EA symptoms from a Japanese family with hereditary EA. Cerebellar atrophy was not evident, but single photon emission computed tomography showed cerebellar hypoperfusion. We identified a novel nonsyno... | Hereditary episodic ataxia (EA) is a heterogeneous group of movement disorders characterized by recurrent spells of truncal ataxia and incoordination 1 . EA type 2 (EA2, MIM: 108500) is an autosomal dominant hereditary EA caused by heterozygous variants in the calcium voltage-gated channel subunit alpha-1A gene ( CACNA... | Supplementary information
The online version contains supplementary material available at 10.1038/s41439-023-00261-w.
Acknowledgements
This work was supported by Grants-in-Aid from MEXT, Japan (#23K06853) and the Cooperative Research Project Program of the Medical Institute of Bioregulation, Kyushu University. We thank... | CC BY | no | 2024-01-16 23:41:59 | Hum Genome Var. 2024 Jan 15; 11:3 | oa_package/09/3a/PMC10788331.tar.gz | |||||
PMC10788332 | 38221521 | Introduction
Holographic display technology can completely record and reconstruct the wavefront information of 3D objects, and it is one of the most promising naked-eye 3D display technologies 1 , 2 . Color holographic 3D display with large viewing angle has always been pursued, and it has important application values ... | Materials and methods
Sample fabrication
In order to fabricate the color liquid crystal grating, firstly, a planar indium tin oxide electrode is deposited on the inner surface of the bottom substrate, and the planar indium tin oxide electrode of the bottom substrate is etched into three different periodic strip indium ... | Results
Structure of the proposed system
As shown in Fig. 1b , the proposed system consists of a red laser, a green laser, a blue laser, three shutters, three beam splitters (BSs), a mirror, a signal controller, a beam expander (BE), three lenses, an SLM, a filter and a color liquid crystal grating. Among them, the re... | Discussion
We have first demonstrated an easy-to-implement method to realize color holographic 3D display system with large viewing angle. To this end, a specially structured color liquid crystal grating is designed on demand and a novel chromatic aberration-free hologram generation mechanism is put forward. In this ca... | Holographic 3D display is highly desirable for numerous applications ranging from medical treatments to military affairs. However, it is challenging to simultaneously achieve large viewing angle and high-fidelity color reconstruction due to the intractable constraints of existing technology. Here, we conceptually propo... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41377-023-01375-0.
Acknowledgements
This work is supported by the National Key Research and Development Program of China (2021YFB2802100) and the National Natural Science Foundation of China (62020106010, 62275009, and U2... | CC BY | no | 2024-01-16 23:41:59 | Light Sci Appl. 2024 Jan 15; 13:16 | oa_package/1a/51/PMC10788332.tar.gz | |
PMC10788333 | 38221523 | Subject terms | Relapse remains common in adults with acute myeloid leukemia (AML), with long-term disease-free survival estimated at 30–40% for patients 60 years or younger treated with chemotherapy [ 1 ]. Pretreatment factors, including age, antecedent hematologic disorder (AHD), prior exposure to chemotherapy, karyotype, and molecu... | Acknowledgements
We would like to acknowledge the contributions of the late Dr. Eli Estey. It was through his guidance that this project was made possible. His kindness, curiosity, and generosity, along with his time and knowledge, left a lasting impact on the authors of this paper and will be greatly missed. This rese... | CC BY | no | 2024-01-16 23:41:59 | Blood Cancer J. 2024 Jan 15; 14(1):5 | oa_package/ad/3d/PMC10788333.tar.gz | |||||
PMC10788334 | 38221538 | Introduction
Lung function gradually decreases over time and varies greatly among individuals 1 . Individuals with impairment of lung function are more likely to suffer from chronic respiratory diseases and have an increased risk of all-cause death 2 . Therefore, it is of particular interest to identify biomarkers asso... | Methods
Population research
Data was obtained from the National Health and Nutrition Examination Survey (NHANES) (2007–2012). NHANES is a complex, stratified, multistage probability sample survey of the non-institutionalized US population. These cross-sectional surveys are used to assess the severity and prevalence of ... | Results
Baseline characteristics of selected participants
A total of 7514 participants were included in the final analysis. The mean age was 40.85 ± 14.28 years old. The mean serum UA levels were 5.34 ± 1.34 mg/dl. Table 1 presents the weighted baseline characteristics according to the serum UA tertiles. All variable... | Discussion
The primary objective of this study was to investigate the independent association between serum UA and lung function in healthy US adults. Our findings revealed a negative association between serum UA and lung function (FEV1 and FVC) after adjusting for potential confounding factors. This relationship was c... | The relationship between serum uric acid and lung function has been controversial. This study aims to determine whether there is an independent relationship between serum uric acid and lung function in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012. Serum uric acid was considered the ex... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51808-y.
Author contributions
The authors’ responsibilities were as follows—W.L., C.W., W.Y.W., Y.H.L., D.H.W.: contributed to data collection, analysis, and manuscript writing; Y.H.L., W.L., X.Y.Y., F.L.: devot... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1300 | oa_package/9d/88/PMC10788334.tar.gz |
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