Datasets:
PRMegathon26
/
PISCES

Dataset card Data Studio Files
xet
 Community
1
pdb_code
stringlengths
4
4
release_date
stringdate
1991-10-15 00:00:00
2026-01-28 00:00:00
classification
stringclasses
1 value
chains
stringlengths
61
5.01k
formula_weight
float64
387
271k
symmetry
stringclasses
66 values
crystal_structure(a|b|c|alpha|beta|gamma)
stringlengths
5
45
exptl_method
stringclasses
6 values
synthesis_comment
stringclasses
73 values
authors
stringlengths
7
521
⌀
publication
stringlengths
15
254
publication_ref(doi|pubmed|csd|issn|astm)
stringlengths
4
62
publication_country
stringclasses
9 values
subtitle
stringlengths
6
213
tags
stringlengths
9
287
sequence_related_designs_above_50_bits
stringlengths
8
1.39k
⌀
sequence_related_natural_proteins_above_50_bits
stringlengths
8
115k
⌀
structure_related_designs_above_95_lddt
stringlengths
7
1.13k
⌀
structure_related_natural_above_95_lddt
stringclasses
247 values
highest_sequence_related_design
stringlengths
7
10
⌀
highest_sequence_related_natural_protein
stringlengths
8
10
⌀
highest_structure_related_design
stringlengths
7
18
⌀
highest_structure_related_natural_protein
stringlengths
7
18
⌀
cath_full
stringlengths
9
3.45k
⌀
data_curation_comments
stringclasses
3 values
3o4b
2010-12-22
other
id:A;type:D;source:synthetic construct;length:143;seq_nat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNG;seq_unnat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTET...
15,875.222
I 2 2 2
50.550|53.520|84.950|90.00|90.00|90.00
X-RAY DIFFRACTION
null
J. Lee;M. Blaber
"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif", Proc.Natl.Acad.Sci.USA, 108, 126-130
10.1073/pnas.1015032108|21173271|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4t: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
3o4d(303);3o4c(302);3o4a(293);3o49(289);4qkr(246);4qks(238);4d8h(231);4ow4(200);3ogf(185);3ol0(98)
1nzk(134);1m16(134);1jt7(132);3fgm(130);1q03(130);1jtc(129);3fjd(129);1pzz(129);2hwm(129);2hz9(129);3fji(129);1k5v(128);2hwa(128);3bah(128);1jt5(128);3bao(128);3fj8(127);2hw9(127);3bau(127);3bag(127);2ntd(127);1q04(127);1jy0(127);1jt3(127);1jt4(127);3baq(126);1k5u(126);3fj9(126);3fja(126);3fjc(126);3hom(126);3b9u(126);...
3o4c(0.9908999801);3o4d(0.9947000146);3o4a(0.9959999919);3o49(0.9930999875)
null
3o4d(303)
1nzk(134)
3o4a(0.9959999919)
2hz9(0.8518000245)
2.80.10.50
null
3o4c
2010-12-22
other
id:A;type:D;source:synthetic construct;length:143;seq_nat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDVHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDVHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDVHIQFQISPEGNG;seq_unnat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDVHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDVHIQFQISPEGNGEVLLKSTET...
15,869.304
I 2 2 2
50.836|53.746|85.550|90.00|90.00|90.00
X-RAY DIFFRACTION
null
J. Lee;M. Blaber
"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif", Proc.Natl.Acad.Sci.USA, 108, 126-130
10.1073/pnas.1015032108|21173271|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4v: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
3o4b(302);3o4d(302);3o4a(292);3o49(288);4qkr(245);4qks(237);4d8h(230);4ow4(199);3ogf(184);3ol0(98)
1nzk(134);1m16(133);1jt7(131);1q03(130);3fgm(129);1jtc(129);3fjd(129);1k5v(128);1pzz(128);3bah(128);2hwm(128);2hz9(128);3fji(128);1jt5(128);3bao(128);2hwa(127);1jt3(127);3baq(126);3fj8(126);1k5u(126);3fj9(126);3fja(126);3fjc(126);2hw9(126);3b9u(126);3bau(126);3bag(126);3fje(126);2ntd(126);3fjf(126);1q04(126);3fjh(126);...
3o4b(0.9872000217);3o4d(0.989199996);3o4a(0.9847000241);3o49(0.988499999)
null
3o4b(302)
1nzk(134)
3o4d(0.989199996)
1ev2(0.8385000229)
2.80.10.50
null
3o4d
2010-12-22
other
id:A;type:D;source:synthetic construct;length:143;seq_nat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNG;seq_unnat:HHHHHHFNLPPGNYKKPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTET...
15,863.255
I 2 2 2
50.372|53.151|84.780|90.00|90.00|90.00
X-RAY DIFFRACTION
null
J. Lee;M. Blaber
"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif", Proc.Natl.Acad.Sci.USA, 108, 126-130
10.1073/pnas.1015032108|21173271|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4p: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
3o4b(301);3o4c(299);3o4a(293);3o49(289);4qkr(256);4qks(247);4d8h(241);4ow4(200);3ogf(191);3ol0(101)
1nzk(134);1m16(134);1jt7(132);3fgm(130);1q03(130);1jtc(129);3fjd(129);1pzz(129);2hwm(129);2hz9(129);3fji(129);1k5v(128);2hwa(128);3bah(128);1jt5(128);3bao(128);3fj8(127);2hw9(127);3bau(127);3bag(127);2ntd(127);1q04(127);1jy0(127);1jt3(127);1jt4(127);3baq(126);1k5u(126);3fj9(126);3fja(126);3fjc(126);3hom(126);3b9u(126);...
3o4b(0.9941999912);3o4c(0.992299974);3o4a(0.9907000065);3o49(0.9886999726)
null
3o4b(301)
1nzk(134)
3o4b(0.9941999912)
2hz9(0.8475999832)
2.80.10.50
null
3ogf
2010-12-22
other
id:A,B,C;type:D;source:synthetic construct;length:91;seq_nat:HHHHHHPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNG;seq_unnat:HHHHHHPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNG
10,072.896
I 21 21 21
81.242|85.414|86.086|90.00|90.00|90.00
X-RAY DIFFRACTION
null
J. Lee;M. Blaber
"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif", Proc.Natl.Acad.Sci.USA, 108, 126-130
10.1073/pnas.1015032108|21173271|0040|0027-8424|PNASA6
US
Crystal structure of difoil-4p homo-trimer: de novo designed dimeric trefoil-fold sub-domain which forms homo-trimer assembly
de novo protein;beta-trefoil
3o4d(192);3o4b(184);3o4c(183);4qkr(182);3o4a(179);3o49(177);4qks(176);4d8h(172);4ow4(139);3ol0(109)
1nzk(100);1jt7(100);1m16(100);1q03(99);3fgm(98);1jtc(98);3fjd(98);1pzz(98);3bao(98);2hwm(97);2hz9(97);3fji(97);3baq(96);3fjc(96);3b9u(96);2hwa(96);3bau(96);1q04(96);3crg(96);1jt3(96);3crh(96);3ba4(96);3cri(96);1jt5(96);3fj8(95);1k5u(95);3fj9(95);3fja(95);1k5v(95);3hom(95);2hw9(95);3bag(95);3fje(95);2ntd(95);3bah(95);3f...
3o4c(0.9541000128);3o4b(0.9501000047)
null
3o4d(192)
1nzk(100)
3o4c(0.9541000128)
2q9x(0.8899999857)
6.20.90.30
null
3ol0
2010-12-22
other
id:A,B,C;type:D;source:synthetic construct;length:48;seq_nat:HHHHHHPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNG;seq_unnat:HHHHHHPVLLKSTETGQYLRINPDGTVDGTRDRSDPHIQFQISPEGNG
5,443.896
P 21 21 21
49.520|53.478|65.868|90.00|90.00|90.00
X-RAY DIFFRACTION
null
J. Lee;M. Blaber
"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif", Proc.Natl.Acad.Sci.USA, 108, 126-130
10.1073/pnas.1015032108|21173271|0040|0027-8424|PNASA6
US
Crystal structure of monofoil-4p homo-trimer: de novo designed monomer trefoil-fold sub-domain which forms homo-trimer assembly
function-competent only;beta-trefoil;de novo protein;trefoil-fold;synthetic protein
3ogf(109);3o4d(102);4qkr(99);3o4c(98);3o4b(98);4qks(96);3o4a(96);3o49(95);4d8h(94);4ow4(72)
1nzk(70);1jt7(70);3fgm(70);1jtc(70);3fjd(70);1pzz(70);1q03(70);1m16(70);2hwm(69);2hz9(69);3fji(69);3bao(69);3b9u(68);2hwa(68);3bau(68);1q04(68);3baq(67);3fj8(67);1k5u(67);3fj9(67);3fja(67);1k5v(67);3bad(67);3fjc(67);3hom(67);2hw9(67);3bag(67);3fje(67);2ntd(67);3bah(67);3fjf(67);3fjh(67);1jy0(67);3crg(67);1jt3(67);3crh(...
3q7x(0.9703000188);3o49(0.9667999744);3q7w(0.9580000043);4qks(0.9624000192);4d8h(0.9627000093);4qkr(0.9548000097);3o4a(0.9510999918);3o4b(0.9592999816)
null
3ogf(109)
1nzk(70)
3q7x(0.9703000188)
2hz9(0.9388999939)
6.20.90.30
null
3ovj
2011-07-06
other
id:A,B,C,D;type:U;source:unknown;length:6;seq_nat:KLVFFA;seq_unnat:KLVFFA
724.909
P 1
9.536|26.008|25.803|62.280|88.590|88.450
X-RAY DIFFRACTION
Klvffa (residues 16-21) from amyloid beta, synthesized
M. Landau;M.R. Sawaya;K.F. Faull;A. Laganowsky;L. Jiang;S.A. Sievers;J. Liu;J.R. Barrio;D. Eisenberg
"Towards a pharmacophore for amyloid", Plos Biol., 9, e1001080-e1001080
10.1371/journal.pbio.1001080|21695112||1544-9173|
US
Structure of an amyloid forming peptide klvffa from amyloid beta in complex with orange g
amyloid-like protofibril;protein fibril
null
null
null
null
3ovj(0)
null
null
null
null
null
3ow9
2011-08-31
other
id:A,B;type:U;source:unknown;length:6;seq_nat:KLVFFA;seq_unnat:KLVFFA
724.909
C 1 2 1
46.053|9.561|20.871|90.000|97.430|90.000
X-RAY DIFFRACTION
Klvffa (residues 16-21) from amyloid beta, synthesized
J.P. Colletier;A. Laganowsky;M. Landau;M. Zhao;A.B. Soriaga;L. Goldschmidt;D. Flot;D. Cascio;M.R. Sawaya;D. Eisenberg
"Molecular basis for amyloid-{beta} polymorphism", Proc.Natl.Acad.Sci.USA, 108, 16938-16943
10.1073/pnas.1112600108|21949245|0040|0027-8424|PNASA6
US
Structure of an amyloid forming peptide klvffa from amyloid beta, alternate polymorph ii
amyloid-like protofibril;protein fibril
null
null
null
null
3ow9(0)
null
null
null
null
null
3p46
2011-01-12
other
id:A,B,C;type:U;source:unknown;length:20;seq_nat:XGPPGPPGLPGEAGPPGPPX;seq_unnat:(ACE)GP(HYP)GP(HYP)GL(HYP)GEAGP(HYP)GP(HYP)(NH2)
1,651.754
C 1 2 1
84.018|17.288|26.048|90.00|91.35|90.00
X-RAY DIFFRACTION
null
C. Byrne;P.A. McEwan;J. Emsley;P.M. Fischer;W.C. Chan
"End-stapled homo and hetero collagen triple helices: a click chemistry approach", Chem.Commun.(Camb.), 47, 2589-2591
10.1039/c0cc04795c|21173963||1359-7345|
UK
Integrin binding collagen peptide
collagen;de novo protein;integrin recognition;integrin alpha 1 beta 1
null
null
null
null
3p46(0)
null
3p46(0)
null
null
null
3p6i
2011-10-12
other
id:A;type:U;source:unknown;length:143;seq_nat:HHHHHHFNLPPGNYKKGGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINP;seq_unnat:HHHHHHFNLPPGNYKKGGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISP...
15,849.183
I 2 2 2
50.901|53.258|84.539|90.00|90.00|90.00
X-RAY DIFFRACTION
Circularly permuted synthetic sequence derived from human acidic fibroblast growth factor with a symmetric deconstruction method. the protein produced by this sequence adopts a beta-trefoil architecture with symmetric primary structure
M. Blaber;J. Lee
To be published
||||
null
Crystal structure of symfoil-4t permutation #2: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
null
null
null
null
null
null
3p6j(0.8791000247)
3o3q(0.74150002)
2.80.10.50
null
3p6j
2011-10-12
other
id:A;type:U;source:unknown;length:143;seq_nat:HHHHHHFNLPPGNYKKGDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDR;seq_unnat:HHHHHHFNLPPGNYKKGDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKSTETGQYLRINPDGTVDGTRDRSDTHIQFQISPEGNGEVLLKS...
15,877.192
P 21 21 21
46.860|57.698|61.412|90.00|90.00|90.00
X-RAY DIFFRACTION
Circularly permuted synthetic sequence derived from human acidic fibroblast growth factor with a symmetric deconstruction method. the protein produced by this sequence adopts a beta-trefoil architecture with symmetric primary structure
M. Blaber;J. Lee
To be published
||||
null
Crystal structure of symfoil-4t permutation #3: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
null
null
null
null
null
null
3p6i(0.8877999783)
3o3q(0.7900000215)
2.80.10.50
null
3pbj
2011-11-30
other
id:A,B,C,D,E,F;type:U;source:unknown;length:31;seq_nat:XEWEALEKKXAALESKLQALEKKHEALEHGX;seq_unnat:(ACE)EWEALEKK(LE1)AALESKLQALEKKHEALEHG(NH2)
3,378.892
P 1 21 1
25.877|38.649|75.659|90.00|95.06|90.00
X-RAY DIFFRACTION
null
M.L. Zastrow;A.F. Peacock;J.A. Stuckey;V.L. Pecoraro
"Hydrolytic catalysis and structural stabilization in a designed metalloprotein", Nat Chem, 4, 118-123
10.1038/nchem.1201|22270627||1755-4349|
UK
Hydrolytic catalysis and structural stabilization in a designed metalloprotein
zinc(ii) binding protein;mercury(ii) binding protein;parallel three-stranded coiled coil;de novo protein;l-penicillamine
2jgo(51)
null
2jgo(0.9850000143);3ljm(0.9848999977);3h5f(0.986800015);5k92(0.9862999916);3h5g(0.9832000136);2x6p(0.9824000001);5u9t(0.986899972);7n2z(0.9664000273);1cos(0.9726999998);5u9u(0.9789999723);7n2y(0.9512000084);6egn(0.9710000157);5kb0(0.9708999991);5kb2(0.9632999897);6ego(0.9574999809);6egp(0.9635000229);6egl(0.9606000185)...
null
2jgo(51)
null
5u9t(0.986899972)
null
1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.30;1.20.5.460;1.20.5.740;6.10....
null
3pg0
2011-12-21
other
id:A;type:D;source:Artificial gene;length:167;seq_nat:GSSHHHHHHHHHHSSGLVPRGSHMGDGYYKLVARHSGKALDVENASTSDGANVIQYSYSGGDNQQWRLVDLGDGYYKLVARHSGKALDVENASTSDGANVIQYSYSGGDNQQWRLVDLGDGYYKLVARHSGKALDVENASTSDGANVIQYSYSGGDNQQWRLVDL;seq_unnat:GSSHHHHHHHHHHSSGLVPRGSHMGDGYYKLVARHSGKALDVENASTSDGANVIQYSYSGGDNQQWRLVDLGDGYYKLVARHSGKALDVE...
18,061.398
P 43 21 2
45.012|45.012|113.439|90.00|90.00|90.00
X-RAY DIFFRACTION
null
A. Broom;A.C. Doxey;Y.D. Lobsanov;L.G. Berthin;D.R. Rose;P.L. Howell;B.J. McConkey;E.M. Meiering
"Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein", Structure, 20, 161-171
10.1016/j.str.2011.10.021|22178248|2005|0969-2126|STRUE6
UK
Crystal structure of designed 3-fold symmetric protein, threefoil
sugar binding;beta-trefoil;symmetric design;engineered module;de novo protein
5xg5(70)
2d20(84);2d22(84);2d23(84);1isv(84);2d24(84);1isw(84);1isx(84);1xyf(84);1isy(84);1isz(84);1it0(84);1v6u(84);1v6v(84);1v6w(84);1v6x(84);2d1z(84);1knl(82);1knm(82);1mc9(82);9cfp(51)
null
null
5xg5(70)
2d20(84)
5xg5(0.7814000249)
3a23(0.8134999871)
2.80.10.50
null
3q7w
2012-01-11
other
id:A;type:U;source:unknown;length:133;seq_nat:HHHHHHEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNG;seq_unnat:HHHHHHEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGN...
14,526.649
P 21 21 21
38.467|46.643|63.921|90.00|90.00|90.00
X-RAY DIFFRACTION
Synthetic sequence derived from human acidic fibroblast growth factor with a symmetric deconstruction method. the protein produced by this sequence adopts a beta-trefoil architecture with symmetric primary structure
L.M. Longo;J. Lee;M. Blaber
"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein", Proc.Natl.Acad.Sci.USA, 110, 2135-2139
10.1073/pnas.1219530110|23341608|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4p/pv1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1
de novo protein;beta-trefoil
null
null
3q7x(0.9735999703);4d8h(0.9873999953);4qkr(0.9779999852);4qks(0.962100029)
null
null
null
4d8h(0.9873999953)
3o3q(0.882700026)
2.80.10.50
null
3q7x
2012-01-11
other
id:A;type:U;source:unknown;length:133;seq_nat:HHHHHHEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNG;seq_unnat:HHHHHHEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGNGEVLLRSTETGQFLRINPDGTVDGTRDRSDPGIQFQISPEGN...
14,526.649
P 21 21 21
46.725|48.666|67.599|90.00|90.00|90.00
X-RAY DIFFRACTION
Synthetic sequence derived from human acidic fibroblast growth factor with a symmetric deconstruction method. the protein produced by this sequence adopts a beta-trefoil architecture with symmetric primary structure
L.M. Longo;J. Lee;M. Blaber
"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein", Proc.Natl.Acad.Sci.USA, 110, 2135-2139
10.1073/pnas.1219530110|23341608|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4p/pv1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1
de novo protein;beta-terfoil;beta-trefoil
null
null
3q7w(0.9717000127);4qkr(0.9674999714);4qks(0.9650999904);4d8h(0.9642000198)
null
null
null
3q7w(0.9717000127)
3o3q(0.875)
2.80.10.50
null
3q7y
2012-01-11
other
id:A;type:U;source:unknown;length:133;seq_nat:HHHHHHPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGNGPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGNGPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGNG;seq_unnat:HHHHHHPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGNGPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGNGPVLLRSTDTGQWLRINPDGTVDGTRDRSDPGIQWQISPDGN...
14,580.712
P 21 21 21
39.485|42.614|66.852|90.00|90.00|90.00
X-RAY DIFFRACTION
Synthetic sequence derived from human acidic fibroblast growth factor with a symmetric deconstruction method. the protein produced by this sequence adopts a beta-trefoil architecture with symmetric primary structure
L.M. Longo;J. Lee;M. Blaber
"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein", Proc.Natl.Acad.Sci.USA, 110, 2135-2139
10.1073/pnas.1219530110|23341608|0040|0027-8424|PNASA6
US
Crystal structure of k15r/e18d/y22w/h41g/f44w/e51d/e53p/k57r/e60d/y64w/h82g/f85w/e90d/e94p/k98r/e101d/y108w/h129g/f132w/e137d symfoil-4p: de novo designed beta-trefoil architecture with symmetric primary structure
de novo protein;beta-trefoil
null
null
null
null
null
null
3q7w(0.9347000122)
3o3q(0.8826000094)
2.80.10.50
null
3qht
2011-05-11
other
id:A,B;type:N;source:Saccharomyces cerevisiae;length:99;seq_nat:GSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGG;seq_unnat:GSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGG|id:C,D;type:U;source:unknown;length:98;seq_nat:G...
11,204.536
P 21 21 2
59.637|175.462|52.830|90.00|90.00|90.00
X-RAY DIFFRACTION
null
R.N. Gilbreth;K. Truong;I. Madu;A. Koide;J.B. Wojcik;N.S. Li;J.A. Piccirilli;Y. Chen;S. Koide
"Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design", Proc.Natl.Acad.Sci.USA, 108, 7751-7756
10.1073/pnas.1102294108|21518904|0040|0027-8424|PNASA6
US
Crystal structure of the monobody ysmb-1 bound to yeast sumo
yeast small ubiquitin-like modifier;de novo protein;smt3;fibronectin type iii
9f00(132);9y5y(120);4u3h(57);4lpw(56);4lpu(53);4lpy(53);4lpv(52);4lpt(52);4m6a(51);4lpx(51);5l2h(50)
2qbw(154);3k2m(152);3ch8(150);3csg(149);2obg(148);3csb(145);2ocf(144);1fnf(142);1ttf(140);1ttg(140);1fna(133);1mfn(129);2mfn(129);2ck2(119);2gee(53);1fnh(51)
null
null
9f00(132)
2qbw(154)
5l2h(0.8309999704)
2qbw(0.8745999932)
2.60.40.2920;2.60.40.1940;2.60.40.3920;2.60.40.2140;2.60.40.380;2.60.40.3760;2.60.40.2710;2.60.40.10;2.60.40.60;2.60.40.3080;2.60.40.3580;2.60.40.290;2.60.40.2840;2.60.40.2420;2.60.40.1200;2.60.40.1870;2.60.40.1220;2.60.40.3780;2.60.40.1930
null
3r2x
2011-05-11
other
id:A;type:N;source:Influenza A virus;length:335;seq_nat:ADPGDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCNIAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEIFPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVLWGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEPGDTITFEATGNLIAPWYAFALNRG...
36,452.797
H 3 2
130.054|130.054|313.735|90.00|90.00|120.00
X-RAY DIFFRACTION
null
S.J. Fleishman;T.A. Whitehead;D.C. Ekiert;C. Dreyfus;J.E. Corn;E.M. Strauch;I.A. Wilson;D. Baker
"Computational design of proteins targeting the conserved stem region of influenza hemagglutinin", Science, 332, 816-821
10.1126/science.1202617|21566186|0038|0036-8075|SCIEAS
US
Crystal structure of the de novo designed binding protein hb36.3 in complex the the 1918 influenza virus hemagglutinin
viral protein/de novo protein;viral protein-de novo protein complex;glycoprotein;hemagglutinin
null
1u84(156)
null
null
3r2x(0)
1u84(156)
9dis(0.4889000058)
1u84(0.9350000024)
1.10.150.80;1.20.120.1600;1.10.10.10;1.20.120.710;1.10.150.50;1.10.10.470;1.10.10.160;1.20.1390.20;1.10.40.30;1.10.150.240;1.10.150.450;1.10.150.20;1.10.150.40;1.10.340.20;1.10.150.120
null
3r3k
2011-11-16
other
id:A,B,C;type:U;source:unknown;length:34;seq_nat:XGELKAIAQELKAIAKELKAIAFELKAIAQGAGX;seq_unnat:(ACE)GELKAIAQELKAIAKELKAIA(PHI)ELKAIAQGAG(ACE)
3,477.891
I 2 2 2
31.660|54.480|128.270|90.00|90.00|90.00
X-RAY DIFFRACTION
Peptide synthesis carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of a parallel 6-helix coiled coil
kih interactions;de novo protein;parallel hexamer;synthetic biology;hydrophobic channel
null
null
6q5n(0.9983999729);4h8g(1);3r46(1);3r48(1);4h8m(0.9955000281);6q5p(1);6q5s(1);6q5j(1);6q5o(0.9779000282);4h7r(1);4h8f(1);4h8o(1);6q5r(1);8a3g(0.9952999949);3r47(0.9593999982);3r4h(0.9851999879);3r4a(0.996900022);6q5q(0.9739000201);5eoj(0.9684000015);5vte(0.975300014);8qac(0.9575999975);8qaa(1);5eon(0.9757000208);8b45(0...
null
null
null
4h8g(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.770;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;1.20.5.3960;6.10.250.2720;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.3290;1....
null
3r46
2011-11-16
other
id:A,B,C,E,F,G;type:U;source:unknown;length:35;seq_nat:XGELKAIAQELKAIAKELKAIAWEDKAIAQGAGYX;seq_unnat:(ACE)GELKAIAQELKAIAKELKAIAWEDKAIAQGAGY(NH2)
3,528.104
P 42 21 2
55.176|55.176|146.591|90.00|90.00|90.00
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of a parallel 6-helix coiled coil cc-hex-d24
kih interactions;de novo protein;coiled coil domain;parallel hexamer;synthetic biology;hydrophobic channel
null
null
6q5n(0.996999979);3r48(1);4h8m(1);6q5j(1);3r3k(1);6q5p(1);6q5s(1);6q5o(0.9797000289);4h7r(1);4h8g(1);4h8o(1);6q5r(1);3r47(0.9580000043);8a3g(0.996999979);3r4a(0.9983999729);4h8f(1);6q5q(0.9792000055);8qaa(1);5eon(0.9575999975);8qac(0.9575999975);3r4h(0.9896000028);8b45(0.996999979);8qab(1);5eoj(0.9523000121);6i1j(0.992...
null
null
null
6q5j(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;1.20.5.470;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
3r47
2011-11-16
other
id:A,B,C,E,F,G,H,I,J,K,L,M;type:U;source:unknown;length:34;seq_nat:XGELKAIAQELKAIAKELKAIAWEHKAIAQGAGX;seq_unnat:(ACE)GELKAIAQELKAIAKELKAIAWEHKAIAQGAG(NH2)
3,387.99
P 42
55.804|55.804|139.875|90.00|90.00|90.00
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of a 6-helix coiled coil cc-hex-h24
kih interactions;hexamer;coiled coil domain;de novo protein;synthetic biology;hydrophobic channel
null
null
6q5k(0.9968000054);3r48(0.9987000227);4h8m(1);6q5h(0.9970999956);6q5n(1);6q5i(0.9954000115);6q5m(0.9550999999);3r46(1);6q5j(1);3r3k(1);6q5p(1);4h7r(1);4h8g(1);6q5s(1);3r4a(1);4h8f(1);4h8o(0.9987000227);4h8l(0.9520000219);6q5r(1);8a3g(1);3r4h(0.9954000115);5eon(0.9545999765);8qac(0.9965000153);7qwc(0.9941999912);8qaa(1)...
null
3r47(0)
null
6q5n(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.2720;6.10.250.1210;1.20.5.470;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;...
null
3r48
2011-11-16
other
id:A,F,G;type:U;source:unknown;length:34;seq_nat:XGELKAIAQELKAIAKELKAIAWEHKAIAQGAGX;seq_unnat:(ACE)GELKAIAQELKAIAKELKAIAWEHKAIAQGAG(NH2)|id:B,C,E;type:U;source:unknown;length:32;seq_nat:XGELKAIAQELKAIAYELKAIAKEDKAIAQGX;seq_unnat:(ACE)GELKAIAQELKAIAYELKAIAKEDKAIAQG(NH2)
3,387.99
C 1 2 1
148.872|50.850|31.681|90.00|91.05|90.00
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of a hetero-hexamer coiled coil
kih interactions;hexamer;coiled coil domain;de novo protein;synthetic biology;hydrophobic channel
null
null
4h8o(1);3r46(1);3r3k(1);6q5n(1);6q5j(1);4h8m(1);6q5p(1);4h8g(1);6q5s(1);6q5o(0.9792000055);4h7r(1);4h8f(1);3r47(0.9743999839);6q5r(1);8a3g(1);3r4a(1);3r4h(0.9872000217);6q5q(0.9763000011);8qaa(1);5eon(0.9575999975);8qac(0.9674000144);8b45(0.9973000288);8qab(1);4dzl(0.997600019);7qdk(1);8bfe(0.9961000085);6i1j(0.9915000...
null
3r48(0)
null
4h8o(1)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;1.20.5.470;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.400;6.10.250.1440;6.10.250...
null
3r4a
2011-11-16
other
id:A,B,C,D;type:U;source:unknown;length:34;seq_nat:XGELAAIKQELAAIKKELAAIKWELAAIKQGAGX;seq_unnat:(ACE)GELAAIKQELAAIKKELAAIKWELAAIKQGAG(NH2)
3,363
I 2 2 2
44.730|50.900|103.060|90.000|90.000|90.000
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of the 4-helix coiled coil cc-tet
kih interactions;tetramer;coiled coil domain;de novo protein;synthetic biology
null
null
3r4h(0.9940000176);6q5n(0.993900001);3r3k(0.996900022);3r46(0.9983999729);4h8m(0.9983000159);6q5j(0.9966999888);3r48(1);8b45(0.9972000122);6i1j(0.9926000237);6q5p(1);4dzl(1);7qwc(0.9700999856);4h8o(0.9983999729);6q5o(0.9743999839);6q5q(0.9808999896);4h7r(0.9983999729);6q5s(1);7qdk(0.9951999784);8bfe(0.9901000261);4dzk(...
null
3r4a(0)
null
4dzl(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.4...
null
3r4h
2011-11-16
other
id:A,B,C,D,E,F;type:U;source:unknown;length:34;seq_nat:XGELAAIKQELAAIKKELAAIKFELAAIKQGAGX;seq_unnat:(ACE)GELAAIKQELAAIKKELAAIK(PHI)ELAAIKQGAG(NH2)
3,449.861
P 43 21 2
84.840|84.840|58.200|90.00|90.00|90.00
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
N.R. Zaccai;B. Chi;A.R. Thomson;A.L. Boyle;G.J. Bartlett;M. Bruning;N. Linden;R.B. Sessions;P.J. Booth;R.L. Brady;D.N. Woolfson
"A de novo peptide hexamer with a mutable channel", Nat.Chem.Biol., 7, 935-941
10.1038/nchembio.692|22037471||1552-4450|
US
Crystal structure of the 4-helix coiled coil cc-tet-phi22
kih interactions;tetramer;coiled coil domain;de novo protein;synthetic biology
null
null
3r4a(0.9984999895);7qwc(0.9947000146);3r47(0.9986000061);6q5k(0.9857000113);3r3k(0.9962999821);6q5n(0.9947000146);6q5i(0.9904999733);6q5h(0.9962999821);3r48(0.9981999993);3r46(0.9965999722);6q5j(0.9965999722);4dzl(1);4h8m(0.9929999709);8b45(0.9987000227);4h8f(0.9962999821);8vhs(0.9743999839);6i1j(0.9923999906);4h8o(0.9...
null
3r4h(0)
null
4dzl(1)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2720;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110...
null
3ra3
2012-08-08
other
id:A,E;type:U;source:unknown;length:28;seq_nat:EIDALEFENDALEQKIAALKQKIASLKQ;seq_unnat:EIDALE(PHI)ENDALEQKIAALKQKIASLKQ|id:B,D;type:U;source:unknown;length:28;seq_nat:KIRRLKQKNARLKQEIAALEYEIAALEQ;seq_unnat:KIRRLKQKNARLKQEIAALEYEIAALEQ
3,287.498
P 32
45.082|45.082|67.593|90.000|90.000|120.000
X-RAY DIFFRACTION
Peptide synthesis was carried out according to standard fmoc spps protocols
T.H. Sharp;M. Bruning;J. Mantell;R.B. Sessions;A.R. Thomson;N.R. Zaccai;R.L. Brady;P. Verkade;D.N. Woolfson
"Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design", Proc.Natl.Acad.Sci.USA, 109, 13266-13271
10.1073/pnas.1118622109|22847414|0040|0027-8424|PNASA6
US
Crystal structure of a section of a de novo design gigadalton protein fibre
fiber;kih interactions;helical reconstruction;coiled coil domain;de novo protein;synthetic biology
null
null
null
null
null
null
6ov9(0.9424999952)
null
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.1870;6.10.250.329...
null
3s0r
2011-06-15
other
id:A,B;type:U;source:unknown;length:30;seq_nat:AEAESALEYAQQALEKAQLALQAARQALKA;seq_unnat:AEAESALEYAQQALEKAQLALQAARQALKA
3,188.565
I 41
45.529|45.529|93.293|90.00|90.00|90.00
X-RAY DIFFRACTION
null
G. Grigoryan;Y.H. Kim;R. Acharya;K. Axelrod;R.M. Jain;L. Willis;M. Drndic;J.M. Kikkawa;W.F. DeGrado
"Computational design of virus-like protein assemblies on carbon nanotube surfaces", Science, 332, 1071-1076
10.1126/science.1198841|21617073|0038|0036-8075|SCIEAS
US
Crystal structure of de novo designed helical assembly protein
de novo protein;interacts with single walled nanotube (swnt)
null
null
5et3(0.9782000184);5hkn(0.981400013);5hkr(0.961499989);6xy0(0.9797999859);4pn8(0.9758999944)
null
5hkr(49)
null
5hkn(0.981400013)
null
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.770;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.2720;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110...
null
3t4f
2011-12-28
other
id:A,B,C,D,E,F;type:U;source:unknown;length:26;seq_nat:XPPGPPGPPGPKGEPGPPGPPGPPGX;seq_unnat:(ACE)P(HYP)GP(HYP)GP(HYP)GPKGE(HYP)GP(HYP)GP(HYP)GP(HYP)G(NH2)
2,228.375
P 1
14.026|23.815|67.657|95.010|94.690|94.860
X-RAY DIFFRACTION
Fmoc solid phase peptide chemistry with n-terminal acetylation and c-terminal amidation
J.A. Fallas;J. Dong;Y.J. Tao;J.D. Hartgerink
"Structural insights into charge pair interactions in triple helical collagen-like proteins", J.Biol.Chem., 287, 8039-8047
10.1074/jbc.M111.296574|22179819|0071|0021-9258|JBCHA3
US
Crystal structure of a kge collagen mimetic peptide at 1.68 a
collagen mimetic peptide;biosynthetic protein;triple helix
null
null
null
null
3t4f(0)
null
null
null
null
null
3tdm
2011-11-16
other
id:A,B,C,D;type:D;source:synthetic construct;length:127;seq_nat:GSESSSQAVVVAIDAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLRGADKVSINTAAVENPSLITQIAQTFG;seq_unnat:GSESSSQAVVVAIDAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLRGADKVSINTAAVENPSLIT...
13,581.423
P 43
60.493|60.493|140.200|90.00|90.00|90.00
X-RAY DIFFRACTION
null
C. Fortenberry;E.A. Bowman;W. Proffitt;B. Dorr;S. Combs;J. Harp;L. Mizoue;J. Meiler
"Exploring symmetry as an avenue to the computational design of large protein domains", J.Am.Chem.Soc., 133, 18026-18029
10.1021/ja2051217|21978247|0004|0002-7863|JACSAT
US
Computationally designed tim-barrel protein, halfflr
tim-barrel;de novo protein;symmetric superfold
3tdn(251);4z08(183);5d2w(183);5d2v(183);5d2t(183);5d2y(178);5d30(178);5d2x(178);5d32(175);5d38(175);5d33(173);5d37(173)
3og3(239);3cwo(196);8s8s(196);1gpw(196);8s8r(196);1thf(196);2wjz(196);1vh7(196);2a0n(196);2w6r(194);2rkx(183);3iio(176);3iip(175);3iiv(173);1h5y(106);1ka9(99);1ox4(74);1ox5(74);1jvn(74);1ox6(74)
null
null
3tdn(251)
3og3(239)
3tdn(0.9448999763)
1gpw(0.9110000134)
3.40.50.720;3.30.160.600;3.40.50.40;3.40.50.10910;3.30.750.24;3.30.160.720;3.40.50.12600
null
3tdn
2011-11-16
other
id:A,B;type:D;source:synthetic construct;length:250;seq_nat:GSESSSQAVVVAIDAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLRGADKVSINTAAVENPSLITQIAQTFGSQAVVVAIDAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLRGADKVSINTAAVENPSLITQIAQTFG;seq_unnat:GS...
26,697.471
P 32 2 1
67.222|67.222|124.658|90.00|90.00|120.00
X-RAY DIFFRACTION
null
C. Fortenberry;E.A. Bowman;W. Proffitt;B. Dorr;S. Combs;J. Harp;L. Mizoue;J. Meiler
"Exploring symmetry as an avenue to the computational design of large protein domains", J.Am.Chem.Soc., 133, 18026-18029
10.1021/ja2051217|21978247|0004|0002-7863|JACSAT
US
Computationally designed two-fold symmetric tim-barrel protein, flr
tim-barrel;de novo protein;symmetric superfold
3tdm(251);4z08(244);5d2w(244);5d2v(244);5d2t(244);5d2y(239);5d30(239);5d2x(239);5d32(237);5d38(237);5d33(235);5d37(235)
3og3(469);2w6r(372);2wjz(261);1vh7(261);2a0n(261);8s8s(260);1gpw(260);8s8r(260);1thf(260);2rkx(244);3cwo(239);3iio(238);3iip(237);3iiv(235);1h5y(155);1ka9(143);1ox4(91);1ox5(91);1jvn(91);1ox6(91);2y85(66);2y88(66);2y89(66);2x30(53);2vep(53);1vzw(53)
null
null
3tdm(251)
3og3(469)
3tdm(0.9415000081)
3iio(0.9114999771)
3.40.50.12600
null
3tq2
2012-09-26
other
id:A;type:U;source:unknown;length:36;seq_nat:XKVSALKEKVSALKEQFLMLMFKVSALKEKVSALKE;seq_unnat:(ACE)KVSALKEKVSALKEQFLMLMFKVSALKEKVSALKE
3,986.906
P 3
22.365|22.365|51.007|90.00|90.00|120.00
X-RAY DIFFRACTION
Solid phase chemistry
M. de March;N. Hickey;S. Geremia
"Analysis of the crystal structure of a parallel three-stranded coiled coil", Proteins, 91, 1254-1260
10.1002/prot.26557|37501532|0867|1097-0134|PSFGEY
US
Merohedral twinning in protein crystals revealed a new synthetic three helix bundle motif
de novo protein;parallel three helix bundle
null
null
6yb0(0.9659000039)
null
3tq2(0)
null
6yb0(0.9659000039)
null
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;1.20.5.3960;6.10.250.740;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.160;6.10.250.850;6.10.250.490;1.20.5.110;1.20.5.250;6.10.250.3290;6.10.250.1200;6.10.250.30;1.20.5.460;1...
null
3twe
2012-03-14
other
id:A,B;type:U;source:unknown;length:27;seq_nat:GNADELYKELEDLQERLRKLRKKLRSG;seq_unnat:GNADELYKELEDLQERLRKLRKKLRSG
3,266.752
I 41
49.043|49.043|41.227|90.000|90.000|90.000
X-RAY DIFFRACTION
Synthesized
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Structural basis for the enhanced stability of highly fluorinated proteins", Proc.Natl.Acad.Sci.USA, 109, 4810-4815
10.1073/pnas.1120112109|22411812|0040|0027-8424|PNASA6
US
Crystal structure of the de novo designed peptide alpha4h
alpha helix;unknown function
null
null
3twf(0.9968000054);4g3b(0.9965999722);4g4l(1);4g4m(0.9505000114)
null
null
null
4g4l(1)
null
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.740;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.400;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.25...
null
3twf
2012-03-14
other
id:A,B;type:U;source:unknown;length:27;seq_nat:GNADELYKEXEDLQERXRKLRKKXRSG;seq_unnat:GNADELYKE(6FL)EDLQER(6FL)RKLRKK(6FL)RSG
3,590.581
I 41
48.349|48.349|39.748|90.000|90.000|90.000
X-RAY DIFFRACTION
Synthesized
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Structural basis for the enhanced stability of highly fluorinated proteins", Proc.Natl.Acad.Sci.USA, 109, 4810-4815
10.1073/pnas.1120112109|22411812|0040|0027-8424|PNASA6
US
Crystal structure of the de novo designed fluorinated peptide alpha4f3a
alpha helix;fluorinated protein;unknown function;de novo designed
null
null
3twe(0.9747999907);4g3b(0.9818000197);4g4l(0.9763000011);3twg(0.9840999842);4g4m(0.9735000134)
null
null
null
3twg(0.9840999842)
null
1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2060;6.10.250.1210;6.10.250.490;1.20.5.110;1.20.5.250;6.10.250.1290;1.20.5.460;1.20.5.740;1.20.5.170;1.20.5.100;6.10.250.2270;1.20.5.70;1.20.5.510;6.10.250.2580;6.10.250.320;6.10.250.3070;1.20.5.220;6.10.250.270;1.20.5.590;1.20.5.140
null
3twg
2012-03-14
other
id:A,B;type:U;source:unknown;length:27;seq_nat:GNADEXYKEXEDXQERXRKXRKKXRSG;seq_unnat:GNADE(3EG)YKE(6FL)ED(3EG)QER(6FL)RK(3EG)RKK(6FL)RSG
3,668.335
P 21 21 2
30.956|36.363|41.457|90.000|90.000|90.000
X-RAY DIFFRACTION
Synthesized
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Structural basis for the enhanced stability of highly fluorinated proteins", Proc.Natl.Acad.Sci.USA, 109, 4810-4815
10.1073/pnas.1120112109|22411812|0040|0027-8424|PNASA6
US
Crystal structure of the de novo designed fluorinated peptide alpha4f3af3d
alpha helix;fluorinated protein;unknown function;de novo designed
null
null
3twf(0.9840999842);4g4m(0.9726999998);4g3b(0.9725999832);3twe(0.9740999937);4g4l(0.9726999998)
null
null
null
3twf(0.9840999842)
null
6.10.250.1960;6.10.250.1110;6.10.250.1210;6.10.250.400;1.20.5.640;1.20.5.460;4.10.180.10;6.10.250.490;1.20.5.740;6.10.250.1560;1.20.5.220;1.20.5.110
null
3u0s
2012-02-01
other
id:A,B;type:N;source:Loligo vulgaris;length:341;seq_nat:MEIPVIEPLFTKVTEDIPGATGPVFDKNGDFYIVASPLSEALTKANSPAEAYKASRGAGEILRIDLKTGKKTVICKPEVNGYGGSPIGCQCDRDANQLFVADMRLGLLVVQTDGTFEEIAKKDSEGRRMQGCAYCAFDYEGNLWITAPAGEVAPADFTISLREKFGSIYCFTTDGQMIQVDTAFQCPAGIAVRHMNDGRPYQLIVAEQPTKKLWSYDIKGPAKIENKKVWGHIPGTHKGGAAGMDFDEDNNLLVANWGSSHIEV...
37,442.449
P 41
87.002|87.002|163.330|90.000|90.000|90.000
X-RAY DIFFRACTION
null
C.B. Eiben;J.B. Siegel;J.B. Bale;S. Cooper;F. Khatib;B.W. Shen;F. Players;B.L. Stoddard;Z. Popovic;D. Baker
"Increased Diels-Alderase activity through backbone remodeling guided by Foldit players", Nat.Biotechnol., 30, 190-192
10.1038/nbt.2109|22267011|2119|1087-0156|NABIF9
US
Crystal structure of an enzyme redesigned through multiplayer online gaming: ce6
loop remodel;multiplayer online gaming;computer-aided design;active site redesign;de novo protein, hydrolase;diels-alder;beta-propeller;foldit;crowdsourcing;substrate specificity;hydrolase;helix-loop-helix;protein engineering;de novo protein;enzyme design;computationally-directed design
null
null
null
null
null
null
null
null
null
null
3u1o
2011-10-26
other
id:A,B;type:D;source:synthetic construct;length:424;seq_nat:MGSHMEVNLRMSWWGGNGRHQVTLKALEEFHKQHPNINVKAEYTGWDGHLSRLTTQIAGGTEPDVMQTNWNWLPIFSKDGTGFYNLFSVKEQLDLAQFDPKELQQTTVNGKLNGIPISVTAMIFYFNDATWAKAGLEYPKTWDELLAAGKVFKEKLGDQYYPVVLCAGQTLVLIRSYMTQKYNIPTIDEANKKFAYSPEQWVEFFTMYKTMVDNHVMPSTKYYASFGKSNHYEMKPWINGEWAGTYMWNSTITKYSDNLT...
48,551.512
P 21 21 2
109.135|129.200|72.178|90.00|90.00|90.00
X-RAY DIFFRACTION
null
F. Richter;R. Blomberg;S.D. Khare;G. Kiss;A.P. Kuzin;A.J. Smith;J. Gallaher;Z. Pianowski;R.C. Helgeson;A. Grjasnow;R. Xiao;J. Seetharaman;M. Su;S. Vorobiev;S. Lew;F. Forouhar;G.J. Kornhaber;J.F. Hunt;G.T. Montelione;L. Tong;K.N. Houk;D. Hilvert;D. Baker
"Computational design of catalytic dyads and oxyanion holes for ester hydrolysis", J.Am.Chem.Soc., 134, 16197-16206
10.1021/ja3037367|22871159|0004|0002-7863|JACSAT
US
Three dimensional structure of de novo designed cysteine esterase ech19, northeast structural genomics consortium target or49
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;hydrolase;ech19;nesg
4jxi(874)
2uvh(823);2uvi(823);2uvj(823);2uvg(819);3jzj(67);3k00(67);3k02(67);3k01(63);2z8f(60);2z8d(60);2z8e(60);3quf(58);8vqk(55);2gh9(51);2i58(51);2hq0(51);2heu(51);2hfb(51);2b3b(50);2b3f(50)
null
null
4jxi(874)
2uvh(823)
4jxi(0.9455000162)
2uvg(0.9379000068)
3.40.190.120;3.40.190.180;3.40.50.10860;3.40.50.2300;3.40.190.10;3.40.190.80;3.40.190.220
null
3u1v
2011-12-07
other
id:A,B,C,D;type:D;source:synthetic construct;length:342;seq_nat:MKTIFSAICPTGVITIGRYIGALRQFVELQHEYNCYFCIADQSAITVWQDPHELRQNIRRLAALYLAVGIDPTQATLFIASEVPAHAQAAWMLQCIVYIGELERMTLFKELSAGKEAVSAGLLTHPPIYAAMILLYNTDIVPVGEYGKQLYELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVDPTKSMYQSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLNIYSTLSGQSIEEL...
38,846.918
P 21 21 21
97.750|100.764|188.225|90.00|90.00|90.00
X-RAY DIFFRACTION
null
F. Richter;R. Blomberg;S.D. Khare;G. Kiss;A.P. Kuzin;A.J. Smith;J. Gallaher;Z. Pianowski;R.C. Helgeson;A. Grjasnow;R. Xiao;J. Seetharaman;M. Su;S. Vorobiev;S. Lew;F. Forouhar;G.J. Kornhaber;J.F. Hunt;G.T. Montelione;L. Tong;K.N. Houk;D. Hilvert;D. Baker
"Computational design of catalytic dyads and oxyanion holes for ester hydrolysis", J.Am.Chem.Soc., 134, 16197-16206
10.1021/ja3037367|22871159|0004|0002-7863|JACSAT
US
X-ray structure of de novo design cysteine esterase fr29, northeast structural genomics consortium target or52
unknown function;northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;structural genomics, unknown function;fr29;nesg;de novo design
null
1mb2(607);3fhj(607);1mau(607);1i6k(607);1i6l(607);1m83(607);1maw(607);1i6m(607);2ov4(607);3fi0(604);1d2r(593);3prh(466);3n9i(302);3sz3(273);2el7(178);3m5w(173);3tzl(173);2yy5(170);2g36(145);2a4m(110);1yi8(109);1yia(109);1yid(109)
null
null
3u1v(0)
1mb2(607)
4yxy(0.386500001)
1d2r(0.9480000138)
3.40.50.620;3.40.50.720;3.40.50.1010;1.10.240.10
null
3u29
2011-12-28
other
id:A,B,C,D,E,F;type:U;source:unknown;length:26;seq_nat:XPPGPPGPPGPKGDPGPPGPPGPPGX;seq_unnat:(ACE)P(HYP)GP(HYP)GP(HYP)GPKGD(HYP)GP(HYP)GP(HYP)GP(HYP)G(NH2)
2,214.349
P 1
14.220|23.247|67.536|94.270|94.740|93.360
X-RAY DIFFRACTION
Fmoc solid phase peptide chemistry with n-terminal acetylation and c-terminal amidation
J.A. Fallas;J. Dong;Y.J. Tao;J.D. Hartgerink
"Structural insights into charge pair interactions in triple helical collagen-like proteins", J.Biol.Chem., 287, 8039-8047
10.1074/jbc.M111.296574|22179819|0071|0021-9258|JBCHA3
US
Crystal structure of a kgd collagen mimetic peptide at 2.0 a
collagen mimetic peptide;biosynthetic protein;triple helix
null
null
null
null
3u29(0)
null
null
null
null
null
3v1a
2012-01-11
other
id:A;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD
5,499.118
P 21 21 21
25.264|33.029|42.916|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-apo1
de novo protein, metal binding protein;metal binding;homodimer;helix-turn-helix;metal binding protein;de novo protein
3v1d(100);3v1c(100);3v1b(100);3v1f(97);3v1e(97);5od9(82);7bww(81);6ypi(78);5od1(77);9s7r(66)
1yzm(66);1z0k(62)
null
null
3v1d(100)
1yzm(66)
3v1b(0.9089999795)
1yzm(0.9016000032)
1.10.287.110;1.10.287.600;1.20.5.420;6.10.140.630;1.10.287.660;1.10.287.3810;4.10.810.10;1.10.12.10;6.10.250.2850;6.10.140.380;6.10.140.790;6.10.140.480;1.10.287.690;1.20.5.4010;6.10.140.360;6.10.250.1570;6.10.250.890;1.10.287.550;6.10.250.870;6.10.250.2860;4.10.860.20;1.10.287.230;6.10.250.3140;6.10.140.420;4.10.860.1...
null
3v1b
2012-01-11
other
id:A,B;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD
5,499.118
P 21 21 21
25.405|41.931|67.159|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-apo2
de novo protein, metal binding protein;metal binding;homodimer;helix-turn-helix;metal binding protein;de novo protein
3v1a(100);3v1d(100);3v1c(100);3v1f(97);3v1e(97);5od9(82);7bww(81);6ypi(78);5od1(77);9s7r(66)
1yzm(66);1z0k(62)
null
1yzm(0.9501000047)
3v1a(100)
1yzm(66)
3v1a(0.9427000284)
1yzm(0.9501000047)
1.10.287.110;1.10.287.600;1.20.5.420;6.10.140.630;4.10.810.10;1.10.287.660;1.10.287.3810;1.10.12.10;6.10.250.2850;6.10.140.790;6.10.140.480;1.10.287.690;1.10.287.1100;6.10.130.40;1.20.5.4010;6.10.140.360;6.10.250.1570;6.10.250.890;1.10.286.70;1.10.287.550;1.10.880.10;6.10.250.870;6.10.250.2860;6.10.140.1480;4.10.860.20...
null
3v1c
2012-01-11
other
id:A,B;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD
5,499.118
P 21 21 21
25.312|29.800|105.412|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-zinc
metal binding;de novo protein, hydrolase;homodimer;de novo protein;hydrolase;helix-turn-helix;metal binding protein
3v1a(100);3v1d(100);3v1b(100);3v1f(97);3v1e(97);5od9(82);7bww(81);6ypi(78);5od1(77);9s7r(66)
1yzm(66);1z0k(62)
null
null
3v1a(100)
1yzm(66)
6ypi(0.9347000122)
1yzm(0.9276000261)
1.10.287.110;1.10.287.600;1.20.5.420;4.10.810.10;1.10.287.660;1.10.287.3810;1.10.12.10;6.10.250.2850;6.10.140.790;6.10.140.480;1.10.287.690;1.10.287.1100;1.20.5.4010;6.10.140.360;6.10.250.890;1.10.286.70;1.10.287.190;1.10.880.10;1.10.287.550;6.10.250.870;6.10.250.2860;1.10.10.490;4.10.860.20;1.10.287.230;1.10.287.1130;...
null
3v1d
2012-01-11
other
id:A,B,C,D,E,F,G,H;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD
5,499.118
P 1
27.720|45.451|62.112|90.04|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-cobalt
de novo protein, metal binding protein;zinc homodimerization;helix-turn-helix;metal binding protein;de novo protein
3v1a(100);3v1c(100);3v1b(100);3v1f(97);3v1e(97);5od9(82);7bww(81);6ypi(78);5od1(77);9s7r(66)
1yzm(66);1z0k(62)
null
null
3v1a(100)
1yzm(66)
3v1c(0.9380000234)
1z0k(0.9294999838)
1.10.287.110;1.10.287.600;1.20.5.420;4.10.810.10;1.10.287.660;6.10.140.630;6.10.250.2850;1.10.12.10;6.10.140.790;1.10.287.690;1.10.287.1100;1.20.5.4010;6.10.140.360;6.10.250.1570;6.10.250.890;1.10.286.70;1.10.287.550;6.10.250.870;6.10.250.2860;6.10.140.1480;4.10.860.20;1.10.287.230;6.10.250.3140;6.10.140.420;4.10.860.1...
null
3v1e
2012-01-11
other
id:A,B;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIESFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIESFIHQAKAAGRMDEVRTLQENLHQLMHEYFQQSD
5,490.085
P 21 21 21
27.052|47.212|55.352|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-zinc h12e mutant
de novo protein, metal binding protein;metal binding;homodimer;helix-turn-helix;metal binding protein;de novo protein
3v1a(97);3v1d(97);3v1c(97);3v1b(97);3v1f(94);5od9(82);7bww(78);6ypi(77);5od1(77);9s7r(66)
1yzm(66);1z0k(63)
3v1a(0.9556999803);3v1b(0.9643999934);7tal(0.9562000036)
1yzm(0.9606999755);1z0k(0.9516000152)
3v1a(97)
1yzm(66)
3v1b(0.9643999934)
1yzm(0.9606999755)
1.10.287.110;1.20.5.420;4.10.810.10;1.10.12.10;6.10.250.2850;6.10.140.790;6.10.140.480;1.10.287.690;1.10.287.1100;1.20.5.4010;6.10.140.360;6.10.250.1570;6.10.250.890;1.10.287.190;1.10.880.10;6.10.250.870;6.10.250.2860;1.10.10.490;4.10.860.20;1.10.287.1130;6.10.250.3140;4.10.860.10;1.10.287.910;1.10.287.540;1.10.287.106...
null
3v1f
2012-01-11
other
id:A,B;type:D;source:ARTIFICIAL GENE;length:48;seq_nat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLEQLMHEYFQQSD;seq_unnat:GSGSPLAQQIKNIHSFIHQAKAAGRMDEVRTLQENLEQLMHEYFQQSD
5,490.085
P 21 21 21
37.241|46.528|62.277|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B.S. Der;M. Machius;M.J. Miley;J.L. Mills;T. Szyperski;B. Kuhlman
"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer", J.Am.Chem.Soc., 134, 375-385
10.1021/ja208015j|22092237|0004|0002-7863|JACSAT
US
Crystal structure of de novo designed mid1-zinc h35e mutant
de novo protein, metal binding protein;metal binding;homodimer;helix-turn-helix;metal binding protein;de novo protein
3v1a(97);3v1d(97);3v1c(97);3v1b(97);3v1e(94);7bww(79);5od9(79);6ypi(77);5od1(74);9s7r(68)
1yzm(66);1z0k(62)
3v1d(0.9678999782);6ypi(0.9581999779)
null
3v1a(97)
1yzm(66)
3v1d(0.9678999782)
1z0k(0.9312999845)
1.10.287.110;1.10.287.600;1.20.5.420;4.10.810.10;1.10.287.3810;1.10.12.10;6.10.250.2850;6.10.140.380;6.10.140.790;6.10.140.480;1.10.287.690;1.10.287.1100;1.20.5.4010;6.10.140.360;6.10.250.890;1.10.286.70;6.10.250.870;6.10.250.2860;4.10.860.20;1.10.287.1130;6.10.250.3140;4.10.860.10;1.10.287.910;1.10.287.540;6.10.140.42...
null
3v45
2012-01-04
other
id:A;type:U;source:unknown;length:169;seq_nat:MARIREVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTALGAWVGGLPAEAVLRVMLEEIKKAPDTLEVTGVHGTEKSAEAARRALLEHHHHHH;seq_unnat:MARIREVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSA...
17,675.244
P 2 2 21
30.031|38.115|128.114|90.000|90.000|90.000
X-RAY DIFFRACTION
null
S. Rajagopalan;C. Wang;K. Yu;A.P. Kuzin;F. Richter;S. Lew;A.E. Miklos;M.L. Matthews;J. Seetharaman;M. Su;J.F. Hunt;B.F. Cravatt;D. Baker
"Design of activated serine-containing catalytic triads with atomic-level accuracy", Nat.Chem.Biol., 10, 386-391
10.1038/nchembio.1498|24705591||1552-4450|
US
Crystal structure of de novo designed serine hydrolase osh55, northeast structural genomics consortium target or130
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg;de novo design
null
null
null
null
null
null
4k0c(0.9275000095)
2dx6(0.8593999743)
null
null
3v86
2012-05-09
other
id:A;type:U;source:unknown;length:27;seq_nat:YVYQLKDEVGELKGEVRALKDEVKDLK;seq_unnat:YVYQLKDEVGELKGEVRALKDEVKDLK
3,171.639
P 3 2 1
35.470|35.470|40.160|90.00|90.00|120.00
X-RAY DIFFRACTION
Chemically synthesized, de novo design protein
C.J. Lanci;C.M. Macdermaid;S.G. Kang;R. Acharya;B. North;X. Yang;X.J. Qiu;W.F. Degrado;J.G. Saven
"Computational design of a protein crystal", Proc.Natl.Acad.Sci.USA, 109, 7304-7309
10.1073/pnas.1112595109|22538812|0040|0027-8424|PNASA6
US
Computational design of a protein crystal
de novo protein;de novo designed helix;helical coil;computational design of a protein crystal
null
null
5u59(0.9556999803);6g6f(0.9617000222)
null
null
null
6g6f(0.9617000222)
null
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.500;1.20.5.3960;6.10.250.2060;6.10.250.1210;6.10.250.490;1.20.5.110;1.20.5.460;1.20.5.740;1.20.5.510;6.10.250.2580;6.10.250.320;6.10.250.3070;1.20.5.220;6.10.250.270;6.10.250.410;1.20.5.140
null
3vb8
2012-06-06
other
id:A,B;type:D;source:artificial gene;length:163;seq_nat:MGSEMSEMSVVDYVVTSFNSTSQMSHELLFSVKKRWFVKPFEHSRRYGLLAYMLLPGNYIKFGLYVLKNQDYARFEIAWVHVDKDGKIEERTVYSIETYWHIFIDIENDLNCPYVLAKFIEMRPEFEKTAWVEESNYSIAEDDIQMVESIKRYLERKIASD;seq_unnat:MGSEMSEMSVVDYVVTSFNSTSQMSHELLFSVKKRWFVKPFEHSRRYGLLAYMLLPGNYIKFGLYVLKNQDYARFEIAWVHVDKDGKIEERT...
19,221.904
P 43 21 2
77.553|77.553|115.741|90.00|90.00|90.00
X-RAY DIFFRACTION
null
E. Procko;R. Hedman;K. Hamilton;J. Seetharaman;S.J. Fleishman;M. Su;J. Aramini;G. Kornhaber;J.F. Hunt;L. Tong;G.T. Montelione;D. Baker
"Computational design of a protein-based enzyme inhibitor", J.Mol.Biol., 425, 3563-3575
10.1016/j.jmb.2013.06.035|23827138|0070|0022-2836|JMOBAK
UK
Crystal structure of engineered protein, northeast structural genomics consortium target or43
northeast structural genomics consortium;structural genomics;psi-biology;de novo protein;nesg
null
3ii2(294);3ii3(294);3ild(292);3ile(292)
null
null
3vb8(0)
3ii2(294)
8vfq(0.3670000136)
3ile(0.9276999831)
2.60.40.2930
null
3vcd
2012-06-06
other
id:A,B,C,D,E,F,G,H;type:N;source:Salmonella enterica;length:194;seq_nat:MSQAIGILELTSIAAGMELGDAMLKSANVDLLVSKTISPGKFLLMLGGDIGAIQQAIETGTSQAGELLVDSLVLANIHPSVLPAISGLNSVDKRQAVGIVETWSVAACISAADRAVKGSNVTLVRVHMAFGIGGKCYMVVAGDVSDVALAVTVASSSAGAYGLLVYASLIPRPHEAMWRQMVEGLEHHHHHH;seq_unnat:MSQAIGILELTSIAAGMELGDAMLKSANVDLLVSKTISPGKFLLM...
19,964.084
H 3 2
137.920|137.920|560.570|90.000|90.000|120.000
X-RAY DIFFRACTION
null
N.P. King;W. Sheffler;M.R. Sawaya;B.S. Vollmar;J.P. Sumida;I. Andre;T. Gonen;T.O. Yeates;D. Baker
"Computational design of self-assembling protein nanomaterials with atomic level accuracy", Science, 336, 1171-1174
10.1126/science.1219364|22654060|0038|0036-8075|SCIEAS
US
Computationally designed self-assembling octahedral cage protein, o333, crystallized in space group r32
self assembling octahedral cage design;electron transport
null
null
null
null
null
null
null
null
null
null
3vjf
2012-03-28
other
id:A,B;type:D;source:synthetic construct;length:103;seq_nat:MYGKLNKLVEHIKELLQQLNKNWHRHQGNLHDMNQQMEQLFQEFQHFMQGNQDDGKLQNMIHEMQQFMNQVDNHLQSESDTVHHFHNKLQELMNNFHHLVHR;seq_unnat:(MSE)YGKLNKLVEHIKELLQQLNKNWHRHQGNLHD(MSE)NQQ(MSE)EQLFQEFQHF(MSE)QGNQDDGKLQN(MSE)IHE(MSE)QQF(MSE)NQVDNHLQSESDTVHHFHNKLQEL(MSE)NNFHHLVHR
12,943.274
P 21 21 2
65.950|102.858|31.344|90.000|90.000|90.000
X-RAY DIFFRACTION
null
R. Arai;N. Kobayashi;A. Kimura;T. Sato;K. Matsuo;A.F. Wang;J.M. Platt;L.H. Bradley;M.H. Hecht
"Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20", J.Phys.Chem.B, 116, 6789-6797
10.1021/jp212438h|22397676|1278|1089-5647|JPCBFK
US
Crystal structure of de novo 4-helix bundle protein wa20
binary patterned design;3d domain swapping;rudimentary enzymatic activities;protein design;four helix bundle;de novo protein
6kos(194);8h7c(105);8h7d(105);8h7e(105)
null
null
null
6kos(194)
null
6kos(0.9225999713)
null
1.10.287.1520;1.20.5.930;6.10.140.1300;1.10.12.10;1.20.5.1430;1.10.287.70;1.10.287.690;1.10.287.3290;6.10.140.1740;1.10.287.2320;1.10.287.210;1.10.287.450;6.10.140.2090;1.20.20.10;1.10.287.710;6.10.230.10;1.20.58.350;6.10.140.1460;1.10.287.920;1.20.5.3800;6.10.250.190;6.10.140.1720;1.10.287.850;1.10.287.380;1.10.287.36...
null
3wn8
2014-08-13
other
id:A,B,C;type:U;source:unknown;length:24;seq_nat:PPGPPGPPGPRGPPGPPGPPGPPG;seq_unnat:P(HYP)GP(HYP)GP(HYP)GPRGP(HYP)GP(HYP)GP(HYP)GP(HYP)G
2,200.345
P 1 21 1
23.285|19.567|49.022|90.00|94.51|90.00
X-RAY DIFFRACTION
This peptide appears most frequently in native collagen
K. Okuyama;M. Haga;K. Noguchi;T. Tanaka
"Preferred side-chain conformation of arginine residues in a triple-helical structure", Biopolymers, 101, 1000-1009
10.1002/bip.22478|24615532|0161|0006-3525|BIPMAA
US
Crystal structure of collagen-model peptide, (pog)3-prg-(pog)4
hsp47 binding;structural protein;collagen-helix
null
null
null
null
null
null
null
null
null
null
3ww7
2014-10-08
other
id:A,B,C;type:U;source:unknown;length:89;seq_nat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAG;seq_unnat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAG
8,914.796
P 21 21 21
41.235|69.709|91.104|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza2 protein
computational protein design;de novo protein;self-assembly
null
null
3wwf(0.9980999827);3wwb(0.9940999746);7zcj(0.99150002);3wwa(0.9968000054);6qsg(0.9962999821);6rei(0.9858999848);6rej(0.9684000015);6rek(0.9728000164);6rel(0.9700999856);6f0t(0.989199996);7ov7(0.9848999977);6reg(0.9862999916);6qse(0.9955000281);7zpw(0.9880999923);6rli(0.9904000163);6qsd(0.9944999814);6reh(0.9858000278);...
1rwl(0.9702000022);1rwi(0.9745000005)
null
null
3wwf(0.9980999827)
1rwi(0.9745000005)
2.40.10.500;2.20.25.650;2.40.128.190;2.40.10.360
null
3ww8
2014-10-08
other
id:A,B;type:U;source:unknown;length:131;seq_nat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAG;seq_unnat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAG
13,156.454
P 21 21 21
48.882|56.213|69.966|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza3 protein
computational protein design;de novo protein;self-assembly
null
null
3ww9(1);6rem(0.993900001);6qsd(0.9897000194);6f0t(0.9743999839);6rej(0.9933999777);3wwa(0.9589999914);6qse(0.9904999733);6rel(0.9641000032);7zcj(0.9562000036);6i38(0.9528999925);7zpw(0.983099997);6reh(0.9775999784);6rei(0.9890999794);6rli(0.9897000194);6f0q(0.9700999856);6f0s(0.9857000113);6i39(0.9692999721);6reg(0.981...
null
null
null
3ww9(1)
1rwl(0.7756999731)
2.40.10.500;2.20.25.400;2.40.128.190;2.30.30.140;2.40.10.360;2.30.30.100;2.20.25.510;2.20.25.10;2.30.30.660
null
3ww9
2014-10-08
other
id:A;type:U;source:unknown;length:259;seq_nat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAG;seq_unnat:GSHMSNT...
25,881.439
P 21 21 21
48.631|56.214|70.101|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza6 protein
computational protein design;de novo protein;self-assembly
null
null
6rei(0.9613000154);3wwa(0.9575999975);6rel(0.9526000023);6qse(0.9720000029);6qsg(0.9642999768);6f0s(0.9575999975);7zcj(0.954400003);7zpw(0.9581000209);6reg(0.9599000216);7ov7(0.9569000006);6reh(0.9566000104);6rli(0.9530000091);6qsf(0.9553999901)
null
null
null
6qse(0.9720000029)
1rwl(0.8779000044)
2.40.10.500;2.40.128.190;2.40.128.660;2.20.25.650;2.40.128.630
null
3wwa
2014-10-08
other
id:A;type:U;source:unknown;length:301;seq_nat:GSHMSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPNGV...
30,123.08
P 21 21 21
40.056|69.498|92.301|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza7 protein after heat treatment
computational protein design;de novo protein;self-assembly
null
null
6qsg(0.9671000242);3ww9(0.9580000043);6rei(0.9620000124);6reg(0.9624999762);6rel(0.9574999809);7ov7(0.9582999945);6reh(0.9634000063);6qse(0.9530000091);7zpw(0.9642000198);6qsd(0.9603999853);6rli(0.9577999711)
null
null
null
6qsg(0.9671000242)
1rwl(0.8910999894)
2.40.10.500;2.40.128.190;2.40.128.660;2.40.10.360;2.110.10.10;2.20.25.650;2.40.128.630;2.20.25.10;2.40.128.650;2.30.30.660
null
3wwb
2014-10-08
other
id:A,B,C;type:U;source:unknown;length:91;seq_nat:GSHMRSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGS;seq_unnat:GSHMRSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGS
9,143.111
P 21 21 21
61.449|63.695|69.903|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza2-sr protein
computational protein design;de novo protein;self-assembly
null
null
3wwf(0.9918000102);3ww7(0.9941999912);3ww8(0.9887999892);6qsd(0.9944999814);6reg(0.9926000237);7ov7(0.9896000028);6qsg(0.9952999949);4zcn(0.9526000023);7zcj(0.9951999784);7zpw(0.9937000275);6rem(0.9925000072);6i39(0.9751999974);6f0t(0.9921000004);6qse(0.9908999801);6rei(0.9926999807);5i1y(0.9616000056);7zph(0.974600017...
1rwi(0.9772999883);1rwl(0.9725000262)
null
null
6qsg(0.9952999949)
1rwi(0.9772999883)
2.40.10.500;2.20.25.400;2.20.25.650;2.40.128.190;2.40.10.360;2.30.30.100;2.20.25.510;2.20.25.10
null
3wwf
2014-10-08
other
id:A,B,C;type:U;source:unknown;length:91;seq_nat:GSHMRSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGS;seq_unnat:GSHMRSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDRGNNRVVKLAAGS
9,143.111
P 21 21 21
36.912|69.701|103.007|90.00|90.00|90.00
X-RAY DIFFRACTION
The protein was designed
A.R.D. Voet;H. Noguchi;C. Addy;D. Simoncini;D. Terada;S. Unzai;S.Y. Park;K.Y.J. Zhang;J.R.H. Tame
"Computational design of a self-assembling symmetrical beta-propeller protein", Proc.Natl.Acad.Sci.USA, 111, 15102-15107
10.1073/pnas.1412768111|25288768|0040|0027-8424|PNASA6
US
Crystal structure of the computationally designed pizza2-sr protein
computational protein design;de novo protein;self-assembly
null
null
3wwb(0.9926999807);3ww7(0.9981999993);3ww8(0.9857000113);6i39(0.9821000099);6qsg(0.9947000146);7zqg(0.9933999777);7zpz(0.9832999706);6reg(0.9901000261);7zpw(0.9940999746);6f0q(0.9794999957);7ov7(0.9921000004);6qse(0.9916999936);7zcj(0.9926999807);5i1y(0.9585000277);6qsd(0.996999979);6rli(0.9908999801);6rei(0.9860000014...
1rwl(0.9711999893);1rwi(0.975399971)
null
null
3ww7(0.9981999993)
1rwi(0.975399971)
2.40.10.500;2.20.25.650;2.40.128.190;2.40.10.360
null
4a29
2012-11-07
other
id:A;type:D;source:SYNTHETIC CONSTRUCT;length:261;seq_nat:MPRYLKGWLEDVVQLSLRRPSVRASRQRPIISLNERILEFNKRNITAIIAVYERKSPSGLDVERDPIEYAKFMERYAVGLSITTEEKYFNGSYETLRKIASSVSIPILMSDFIVKESQIDDAYNLGADTVLLIVKILTERELESLLEYARSYGMEPLILINDENDLDIALRIGARFIGIMSRDFETGEINKENQRKLISMIPSNVVKVAKLGISERNEIEELRKLGVNAFLISSSLMRNPEKIKELIEGSLEHHHHHH;seq...
29,710.219
P 21 21 21
53.940|62.590|79.810|90.00|90.00|90.00
X-RAY DIFFRACTION
null
L. Giger;S. Caner;R. Obexer;P. Kast;D. Baker;N. Ban;D. Hilvert
"Evolution of a designed retro-aldolase leads to complete active site remodeling", Nat.Chem.Biol., 9, 494-498
10.1038/nchembio.1276|23748672||1552-4469|
US
Structure of the engineered retro-aldolase ra95.0
engineered enzyme;de novo protein;directed evolution;retro-aldolase
9mya(502);9myb(481);4lny(473);4ijb(461);4lt9(447)
4a2s(491);4a2r(482);3tc7(480);8w3y(477);8w3z(477);8w40(477);3tc6(473);3ud6(469);3nxf(469);3o6y(469);3nyz(456);3nz1(456);3hoj(448);1juk(448);1jul(448);1igs(448);1lbl(446);1a53(446);1lbf(446);3uxa(433);3uxd(433);3uy7(433);3uy8(427);3uyc(416);3uzj(413);3uz5(413);2c3z(400);1j5t(111);1i4n(111);1vc4(105);3qja(104);3t40(104);...
9mya(0.9763000011)
null
9mya(502)
4a2s(491)
9mya(0.9763000011)
3ud6(0.9445999861)
3.20.20.190;3.20.20.10;3.20.20.390;3.20.20.60;3.20.20.410;3.20.20.380;3.20.20.120;3.20.20.150;3.20.20.220;3.20.20.80;3.20.20.20;3.20.20.110;3.20.20.70;3.20.20.370;3.20.20.140
null
4atz
2013-02-27
other
id:A,B,C;type:N;source:Human adenovirus C serotype 5;length:203;seq_nat:MAHHHHHHGSGAITVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLNNSFLDPEYWNFRNGDLTEGNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTPSAYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE;seq_unnat:MAHHHHHHGSGAITVGNKNNDKLTLWTTPAPSPNCR...
21,894.42
P 21 21 21
109.600|112.100|129.670|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Dreier;A. Honegger;C. Hess;G. Nagy-Davidescu;P.R. Mittl;M.G. Grutter;N. Belousova;G. Mikheeva;V. Krasnykh;A. Pluckthun
"Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters", Proc. Natl. Acad. Sci. U.S.A., 110, E869-E877
10.1073/pnas.1213653110|23431166|0040|1091-6490|PNASA6
US
Ad5 knob in complex with a designed ankyrin repeat protein
viral protein/de novo protein;viral protein-de novo protein complex;protein design;darpin
5oou(264);2bkg(261);7z72(258);7b4w(258);5oos(258);8ve7(256);5op3(255);6c9k(255);8ql6(254);8ql5(254);8ql9(254);9u6a(254);8ql2(254);8ql3(254);9f8g(254);8qlb(254);8qla(254);8ql7(254);8ql8(254);8qea(254);8ql4(254);4dui(254);9fe2(252);9fe3(252);6fp9(252);7b4t(251);4j7w(251);4j8y(251);9f22(250);9gnb(247);7dng(246);7dnf(246);...
3zu7(259);3nog(255);2p2c(254);4drx(254);4dx6(252);4dx7(252);9fhc(252);2j8s(252);9fhg(252);9fhj(252);9hao(252);9hci(252);4dx5(252);9kcq(251);9kbu(251);1svx(249);3noc(249);4f6r(248);2y1l(246);2v5q(244);2bkk(241);3q9n(229);3q9u(229);3zuv(197);4grg(190);2v4h(188);3hg0(187);1awc(187);2xzt(184);2y0b(184);2xzd(183);3twt(117);...
2qyj(0.9684000015);6c9k(0.9521999955);8aed(0.9520000219);7dne(0.9566000104);5oou(0.9538000226);8qlb(0.9595999718);9f22(0.9570000172);8ql2(0.9588999748);8ql5(0.9562000036);8ql4(0.9557999969);8ql6(0.9587000012);8ql7(0.9587000012);8qea(0.956700027);7z7e(0.954400003);8ql3(0.9585000277);8ql8(0.9566000104);8qla(0.9581000209)...
3zu7(0.9724000096)
5oou(264)
3zu7(259)
2qyj(0.9684000015)
3zu7(0.9724000096)
1.10.10.10;1.10.10.2400;1.25.40.70;1.10.220.10;1.25.40.40;1.25.10.10;1.25.40.850;1.25.40.20
null
4d49
2016-01-13
other
id:A,B,E,F;type:D;source:SYNTHETIC CONSTRUCT;length:246;seq_nat:GPGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIKEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIKEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIKEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIKEAVWAIANIASGNNEMKQKLEEAGALPALEKLQSHANEEVQKNAQAALEAFNS;seq_unnat:GP...
25,851.041
P 1 21 1
88.570|51.730|107.610|90.00|90.16|90.00
X-RAY DIFFRACTION
null
C. Reichen;C. Forzani;T. Zhou;F. Parmeggiani;S.J. Fleishman;P.R.E. Mittl;C. Madhurantakam;A. Honegger;C. Ewald;O. Zerbe;D. Baker;A. Caflisch;A. Pluckthun
"Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition", J.Mol.Biol., 428, 4467
10.1016/J.JMB.2016.09.012|27664438|0070|0022-2836|JMOBAK
UK
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition
de novo protein-peptide complex;de novo protein/peptide
5mfk(461);5mfj(437);5mfi(437);4d4e(412);5mfb(399);5mfe(298);5mfn(298);5aei(298);5mfg(298);5mff(298);5mfh(298);5mfl(293);4v3q(292);5mfd(290);4v3o(287);4db8(286);6s9l(283);6s9o(283);6sa7(283);6s9m(282);6s9n(281);4v3r(280);7r0r(277);7qnp(272);6s9p(270);6sa8(269);6sa6(262);5mfo(243);4db6(239);4db9(239);4dba(217);4rzp(187);...
4plq(290);4plr(287);4pls(282);4bpl(149);4bqk(149);2yns(149);4b8o(149);4b8p(149);4b8j(149);4rxh(146);3tpm(143);2c1m(143);4u54(143);4u5u(143);4u5v(143);3ve6(143);4u5l(143);4u5n(143);4u5o(143);4u58(143);4u5s(143);3l3q(143);3btr(143);1y2a(143);4zdu(143);1ial(143);3zir(143);2ynr(143);3zin(143);3zio(143);3zip(143);3ziq(143);...
5mfk(0.9611999989);5mfj(0.9520000219)
null
5mfk(461)
4plq(290)
5mfk(0.9611999989)
4pls(0.8952000141)
1.25.40.250;1.20.930.10;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.170;1.20.1440.250;1.25.40.180;1.25.40.150;1.20.58.690;1.25.40.20;1.25.40.370
null
4d4e
2016-01-13
other
id:A,B;type:D;source:SYNTHETIC CONSTRUCT;length:254;seq_nat:MRGSHHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIKNAVAAIANIAAGNNEQIQKLIEAGALSPLVKLLDDASEEVIKNAVAAIANIAAGNNEQIQKLIEAGALSPLVKLLDDASEEVIKNAVAAIANIAAGNNEQIQKLIEAGALSPLVKLLDDASEEVIKNAVAAIANIAAGNNEMKQKLEEAGALPALEKLQSHANEEVQKNAQAALEAFNS;seq_unna...
26,373.705
P 21 21 21
51.810|68.670|126.840|90.00|90.00|90.00
X-RAY DIFFRACTION
null
C. Reichen;C. Forzani;T. Zhou;F. Parmeggiani;S.J. Fleishman;P.R.E. Mittl;C. Madhurantakam;A. Honegger;C. Ewald;O. Zerbe;D. Baker;A. Caflisch;A. Pluckthun
"Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition", J.Mol.Biol., 428, 4467
10.1016/J.JMB.2016.09.012|27664438|0070|0022-2836|JMOBAK
UK
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition
de novo protein;armadillo repeat protein
4d49(421);5mfk(421);5mfb(420);5mfj(398);5mfi(398);4db8(273);4v3q(271);4v3o(266);5mfe(259);5mfn(259);5aei(259);5mfg(259);5mff(259);5mfh(259);5mfl(257);6s9m(254);6s9n(254);6s9o(254);6s9p(252);5mfd(251);6s9l(250);6sa7(248);7r0r(243);4v3r(241);7qnp(237);4db6(235);4db9(235);6sa8(234);6sa6(228);4dba(213);5mfo(212);4rzp(178);...
4plr(268);4plq(251);4pls(248);4bpl(136);4bqk(136);2yns(136);4b8o(136);4b8p(136);4b8j(136);4rxh(132);3tpm(128);2c1m(128);4u54(128);4u5u(128);4u5v(128);3ve6(128);4u5l(128);4u5n(128);4u5o(128);4u58(128);4u5s(128);3l3q(128);3btr(128);1y2a(128);4zdu(128);1ial(128);3zir(128);2ynr(128);3zin(128);3zio(128);3zip(128);3ziq(128);...
5mfk(0.9717000127)
null
4d49(421)
4plr(268)
5mfk(0.9717000127)
4pls(0.8876000047)
1.25.40.250;1.20.930.10;1.20.58.1280;1.25.40.90;1.25.10.10;1.25.40.550;1.20.1050.10;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.20.58.690;1.25.40.580;1.20.58.1320;1.20.1660.10;1.25.40.850;1.25.40.290;1.10.10.2400;1.25.40.450;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.170;1.25.40.310;1.10.220...
null
4d8h
2013-01-16
other
id:A;type:D;source:Synthetic;length:133;seq_nat:HHHHHHEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPEGNGEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPEGNGEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPEGNG;seq_unnat:HHHHHHEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPEGNGEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPEGNGEVLLRSTETGQLLRINPDGTVDGTRDRSDPGIQLQISPE...
14,322.552
P 21 21 21
46.584|48.696|64.876|90.00|90.00|90.00
X-RAY DIFFRACTION
null
L.M. Longo;J. Lee;M. Blaber
"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein", Proc.Natl.Acad.Sci.USA, 110, 2135-2139
10.1073/pnas.1219530110|23341608|0040|0027-8424|PNASA6
US
Crystal structure of symfoil-4p/pv2: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 2 (6xleu / pv1)
symfoil;pre-biotic;beta-trefoil;de novo protein;symmetric
4qkr(265);4qks(262);3o4d(246);3o4b(235);3o4c(233);3o4a(227);3o49(223);4ow4(185);3ogf(175);3ol0(95)
3snv(219);3o3q(94);1q03(89);1nzk(88);1pzz(87);2hwm(87);1m16(87);3bao(87);1k5v(86);3bah(86);2hz9(86);3fji(86);1jt3(86);1jt5(86);1jt7(85);3baq(85);3fj8(85);1k5u(85);3fj9(85);3fja(85);2hw9(85);3b9u(85);2hwa(85);3bau(85);3bag(85);3fje(85);2ntd(85);3fjf(85);1q04(85);3fjh(85);1jy0(85);3crg(85);3crh(85);1jt4(85);3ba4(85);3cri...
3q7w(0.9894000292);4qks(0.9707999825);3q7x(0.9670000076);4qkr(0.9624000192)
null
4qkr(265)
3snv(219)
3q7w(0.9894000292)
3o3q(0.8705000281)
2.80.10.50
null
4dac
2012-05-02
other
id:A,B,C,D;type:U;source:unknown;length:28;seq_nat:XEVYKLDANVKRLEKEVGKLEGEVARLX;seq_unnat:(ACE)EVYKLDANVKRLEKEVGKLEGEVARL(NH2)
3,016.514
P 6
63.669|63.669|40.401|90.000|90.000|120.000
X-RAY DIFFRACTION
null
C.J. Lanci;C.M. Macdermaid;S.G. Kang;R. Acharya;B. North;X. Yang;X.J. Qiu;W.F. Degrado;J.G. Saven
"Computational design of a protein crystal", Proc.Natl.Acad.Sci.USA, 109, 7304-7309
10.1073/pnas.1112595109|22538812|0040|0027-8424|PNASA6
US
Crystal structure of computationally designed protein p6d
computationally designed protein;computational protein design;three helix coiled coil;coiled-coil protein;alpha-helix;acylated n-terminus;synthetic;de novo protein;de novo design;three-helix bundle
null
null
1kdd(0.9595999718);1kd9(0.9605000019);1kd8(0.9578999877)
null
null
null
1kd9(0.9605000019)
null
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.3290;6.10.250.120...
null
4db6
2012-05-16
other
id:A;type:D;source:synthetic construct;length:212;seq_nat:MRGSHHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSHENEKIQKEAQEALEKLQSH;seq_unnat:MRGSHHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIAS...
22,482.998
I 2 2 2
42.960|91.580|92.800|90.00|90.00|90.00
X-RAY DIFFRACTION
null
C. Madhurantakam;G. Varadamsetty;M.G. Grutter;A. Pluckthun;P.R. Mittl
"Structure-based optimization of designed Armadillo-repeat proteins", Protein Sci., 21, 1015-1028
10.1002/pro.2085|22544642|0795|0961-8368|PRCIEI
US
Designed armadillo repeat protein (yiiim3aii)
de novo protein;armadillo repeat motif;solenoid repeat
4db9(385);4dba(376);5mfo(362);4db8(361);4v3q(351);5mfe(348);5mfn(348);5aei(348);5mfg(348);5mff(348);5mfh(348);6s9m(348);5mfl(348);7r0r(348);6s9l(347);6s9n(347);6sa7(345);7qnp(344);6s9o(344);4v3o(340);5mfd(338);6sa6(338);6s9p(337);4v3r(332);6sa8(310);5mfj(247);5mfi(247);4d49(244);5mfk(244);4d4e(232);5mfb(207);2ru4(197);...
1ee4(141);1ee5(141);1un0(140);2c1t(140);1bk5(139);1bk6(139);1wa5(138);3tpm(136);2c1m(136);3ve6(136);3l3q(136);3btr(136);1y2a(136);1ial(136);3tj3(135);2jdq(135);1ejl(135);3knd(135);1ejy(135);1pjm(135);1iq1(135);1pjn(135);3q5u(135);1q1s(135);1q1t(135);3oqs(135);3rz9(135);9cle(135);9cl8(135);9clf(135);9clg(135);3rzx(135);...
5mfo(0.9532999992);6s9m(0.9519000053);4db8(0.9585000277);6s9n(0.9527999759);6s9l(0.9509999752);6s9p(0.9516000152);6sa7(0.9535999894);6sa8(0.9519000053)
null
4db9(385)
1ee4(141)
4db8(0.9585000277)
3tj3(0.8442999721)
1.20.930.10;1.25.40.250;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.25.40.60;1.20.1050.10;1.25.40.240;1.25.40.40;1.25.40.70;1.20.58.1320;1.20.1660.10;1.25.40.850;1.25.40.290;1.10.10.2400;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.170;1.10.220.10;1.20.1440.250;1.20.58.690
null
4db8
2012-05-16
other
id:A,B,C,D;type:D;source:synthetic construct;length:255;seq_nat:MRGSHHHHHHGSELPQMTQQLNSDDMQEQLSATRKFSQILSDGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSHENEKIQKEAQEALEKLQSH;seq...
26,953.939
P 1 21 1
58.002|113.643|85.592|90.00|106.83|90.00
X-RAY DIFFRACTION
null
C. Madhurantakam;G. Varadamsetty;M.G. Grutter;A. Pluckthun;P.R. Mittl
"Structure-based optimization of designed Armadillo-repeat proteins", Protein Sci., 21, 1015-1028
10.1002/pro.2085|22544642|0795|0961-8368|PRCIEI
US
Designed armadillo-repeat protein
armadillo repeat;de novo protein;solenoid repeat
4v3q(426);5mfe(413);5mfn(413);5aei(413);5mfg(413);5mff(413);5mfh(413);4v3o(413);7r0r(413);5mfl(408);7qnp(405);6sa7(405);6s9l(404);6s9m(402);6s9n(402);6s9o(399);5mfd(396);4v3r(394);6s9p(392);6sa6(388);4dba(376);6sa8(370);4db6(361);4db9(349);5mfo(333);4d49(292);5mfk(292);5mfj(291);5mfi(291);4d4e(270);5mfb(240);2ru4(218);...
1un0(176);2c1t(176);1ee4(175);1ee5(175);1wa5(175);1bk5(174);1bk6(174);3tj3(159);2jdq(159);3tpm(155);2c1m(155);3ve6(155);3l3q(155);3btr(155);1y2a(155);1ial(155);1ejl(154);3knd(154);1ejy(154);1pjm(154);1iq1(154);1pjn(154);3q5u(154);1q1s(154);1q1t(154);3oqs(154);3rz9(154);9cle(154);9cl8(154);9clf(154);9clg(154);3rzx(154);...
null
null
4v3q(426)
1un0(176)
4db6(0.9424999952)
3tj3(0.8162999749)
1.20.930.10;1.25.40.250;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.25.40.60;1.20.1050.10;1.25.40.240;1.20.58.110;1.25.40.750;1.25.40.40;1.25.40.70;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.170;1.20.1440.250;1.25.40.180;1.25.40.150;1.20.58.690
null
4db9
2012-05-16
other
id:A,B,C,D,E,F;type:D;source:synthetic construct;length:212;seq_nat:MRGSHHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGAEPALEQLQSSPNEKIQKEAQEALEKIQSH;seq_unnat:MRGSHHHHHHGSELPQMVQQLNSPDQQELQS...
22,325.787
C 2 2 21
131.920|228.880|116.530|90.00|90.00|90.00
X-RAY DIFFRACTION
null
C. Madhurantakam;G. Varadamsetty;M.G. Grutter;A. Pluckthun;P.R. Mittl
"Structure-based optimization of designed Armadillo-repeat proteins", Protein Sci., 21, 1015-1028
10.1002/pro.2085|22544642|0795|0961-8368|PRCIEI
US
Designed armadillo repeat protein (yiiim3aiii)
de novo protein;armadillo repeat motif;solenoid repeat
4db6(383);5mfo(376);4dba(361);4v3o(349);4db8(346);5mfe(344);5mfn(344);5aei(344);5mfg(344);5mff(344);5mfh(344);5mfl(343);4v3q(341);6s9m(334);7r0r(334);6s9l(333);6s9n(333);5mfd(333);6sa7(331);7qnp(330);6s9o(330);4v3r(325);6sa6(324);6s9p(323);6sa8(319);5mfj(251);5mfi(251);4d49(242);5mfk(242);4d4e(231);5mfb(213);2ru4(197);...
1ee4(138);1ee5(138);1un0(138);2c1t(138);1bk5(137);1bk6(137);1wa5(137);3tj3(131);2jdq(131);3tpm(124);2c1m(124);3ve6(124);3l3q(124);3btr(124);1y2a(124);1ial(124);1ejl(123);3knd(123);1ejy(123);1pjm(123);1iq1(123);1pjn(123);3q5u(123);1q1s(123);1q1t(123);3oqs(123);3rz9(123);9cle(123);9cl8(123);9clf(123);9clg(123);3rzx(123);...
5mfe(0.9528999925)
null
4db6(383)
1ee4(138)
5mfe(0.9528999925)
1bk5(0.8241000175)
1.25.40.250;1.20.930.10;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.20.1050.10;1.25.40.750;1.25.40.40;1.25.40.70;1.10.220.100;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.810;1.25.40.170;1.10.220.10;1.20.1440.250;1.25.40.180;1.10.110.10;1.20.58.690;1.25.4...
null
4dba
2012-05-16
other
id:A,B,C,D;type:D;source:synthetic construct;length:212;seq_nat:MRGSHHHHHHGSELPQMTQQLNSDDMQEQLSATRKFSQILSDGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSHENEKIQKEAQEALEKLQSH;seq_unnat:MRGSHHHHHHGSELPQMTQQLNSDDMQEQLSATRK...
22,628.092
P 1
56.151|60.603|61.862|74.82|89.55|75.53
X-RAY DIFFRACTION
null
C. Madhurantakam;G. Varadamsetty;M.G. Grutter;A. Pluckthun;P.R. Mittl
"Structure-based optimization of designed Armadillo-repeat proteins", Protein Sci., 21, 1015-1028
10.1002/pro.2085|22544642|0795|0961-8368|PRCIEI
US
Designed armadillo repeat protein (yiim3aii)
de novo protein;armadillo repeat motif;solenoid repeat
4db6(377);4db8(377);4db9(365);5mfo(342);4v3q(331);5mfe(329);5mfn(329);5aei(329);5mfg(329);5mff(329);5mfh(329);5mfl(329);7r0r(329);6s9l(328);6s9m(328);6s9n(328);6s9o(326);7qnp(325);6sa7(325);4v3o(320);6s9p(320);5mfd(319);6sa6(319);4v3r(313);6sa8(291);5mfj(227);5mfi(227);4d49(224);5mfk(224);2ru4(218);4d4e(212);5mfb(187);...
1ee4(139);1ee5(139);1un0(139);2c1t(139);1bk5(138);1bk6(138);1wa5(138);3tpm(130);2c1m(130);3ve6(130);3l3q(130);3btr(130);1y2a(130);1ial(130);3tj3(128);2jdq(128);1ejl(128);3knd(128);1ejy(128);1pjm(128);1iq1(128);1pjn(128);3q5u(128);1q1s(128);1q1t(128);3oqs(128);3rz9(128);9cle(128);9cl8(128);9clf(128);9clg(128);3rzx(128);...
null
null
4db6(377)
1ee4(139)
4db6(0.9308999777)
1bk5(0.8335000277)
1.20.930.10;1.25.40.250;1.20.58.1280;1.20.970.10;1.20.5.1430;1.25.40.90;1.25.10.10;1.25.40.240;1.20.58.110;1.25.40.750;1.10.10.200;1.25.40.70;1.25.40.40;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.170;1.20.1440.250;1.25.40.180;6.10.140.180;1.25.40.150;1.20.58...
null
4drt
2012-04-18
other
id:A;type:D;source:artificial gene;length:365;seq_nat:MDDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPALLAHMMTSYVIGQAMKAGKFKETDLVTIGNDAWATGNPVLKGASLMFLKPGMQVPVSQLIRGINLQDGADAAVAMADFAAGSQDAFVGLMNSYVNALGLKNTHFQTVSGGDADGQYSSARDMALIGQALIRDVPNEYSIFKEKEFTFNGIRQLNRNGLLWDNSLNVDGIMTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFET...
40,088.23
P 32
50.114|50.114|134.205|90.00|90.00|120.00
X-RAY DIFFRACTION
null
S. Rajagopalan;C. Wang;K. Yu;A.P. Kuzin;F. Richter;S. Lew;A.E. Miklos;M.L. Matthews;J. Seetharaman;M. Su;J.F. Hunt;B.F. Cravatt;D. Baker
"Design of activated serine-containing catalytic triads with atomic-level accuracy", Nat.Chem.Biol., 10, 386-391
10.1038/nchembio.1498|24705591||1552-4450|
US
Three dimensional structure of de novo designed serine hydrolase osh26, northeast structural genomics consortium (nesg) target or89
northeast structural genomics consortium;structural genomics;psi-biology;de novo protein;nesg
null
1z6f(707);1nzu(707);3mzd(707);3beb(707);3mze(707);3bec(707);3mzf(707);1nzo(707);1sdn(705);1hd8(705);1nj4(705);3itb(444);3it9(444);3ita(444);3a3j(353);3mfd(88);1tvf(85);3hum(85);3hun(85);1j9m(81);1es5(80);1skf(80);1xp4(80);1es3(79);1es4(79);1esi(78);1es2(78)
null
null
4drt(0)
1z6f(707)
8wwc(0.3125999868)
1nzu(0.9474999905)
3.40.710.10;2.60.410.10;2.30.140.30
null
4dui
2013-02-27
other
id:A;type:D;source:ARTIFICIAL GENE;length:171;seq_nat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVNAIDIMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLHLAAIMGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLN;seq_unnat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVNAIDI(SME)GST...
18,084.439
P 41 21 2
43.400|43.400|143.120|90.00|90.00|90.00
X-RAY DIFFRACTION
null
L. Pecqueur;C. Duellberg;B. Dreier;Q. Wang;C. Jiang;A. Pluckthun;T. Surrey;B. Gigant;M. Knossow
To be published
||||
null
Darpin d1 binding to tubulin beta chain (not in complex)
tubulin beta chain;beta-tubulin;darpin;tubulin;de novo protein;artificial ankyrin repeat proteins
8ql6(342);8ql5(342);8ql9(342);9u6a(342);8ql2(342);8ql3(342);9f8g(342);8qlb(342);8qla(342);8ql7(342);8ql8(342);8qea(342);8ql4(342);7dng(298);7dnf(298);5oos(297);4j7w(295);4j8y(295);5oou(291);5op3(291);2bkg(290);9fe2(290);9fe3(290);5kng(284);5knh(284);4ydw(283);6fp9(281);9f07(280);5lw2(279);8u1b(274);9dmi(274);9f22(273);...
4drx(342);4f6r(302);2y1l(294);9kcq(293);9kbu(293);4dx6(290);2p2c(290);4dx7(290);9fhc(290);3zu7(290);1svx(290);3noc(290);2j8s(290);9fhg(290);9fhj(290);9hao(290);9hci(290);4dx5(290);3nog(289);2v5q(284);2bkk(282);3q9n(244);3q9u(244);3zuv(233);2xzd(232);2y0b(232);2xzt(231);3hg0(229);4grg(222);2v4h(222);1awc(193);2zgd(132);...
4j7w(0.9523000121);5kng(0.9542000294);4j8y(0.9535999894)
null
8ql6(342)
4drx(342)
5kng(0.9542000294)
3q9n(0.9301999807)
1.10.10.2400;1.25.40.70;1.10.220.10
null
4dzk
2012-08-29
other
id:A;type:U;source:unknown;length:32;seq_nat:GEIAAIKQEIAANKKEIAAIKWEIAAIKQGYG;seq_unnat:GEIAAIKQEIAANKKEIAAIKWEIAAIKQGYG
3,431.996
P 3 2 1
38.150|38.150|44.300|90.00|90.00|120.00
X-RAY DIFFRACTION
Solid state peptide synthesis
J.M. Fletcher;A.L. Boyle;M. Bruning;G.J. Bartlett;T.L. Vincent;N.R. Zaccai;C.T. Armstrong;E.H. Bromley;P.J. Booth;R.L. Brady;A.R. Thomson;D.N. Woolfson
"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology", ACS Synth Biol, 1, 240-250
10.1021/sb300028q|23651206||2161-5063|
US
A de novo designed coiled coil cc-tri-n13
de novo protein
null
null
6i1j(0.9965999722);8b45(0.9929000139);3r4a(0.9983000159);4dzl(0.9983999729);4dzn(0.9987000227);3r4h(0.9941999912);7qwc(0.9872999787);3r47(1);6q5n(1);3r48(0.9943000078);4h8g(1);4h7r(0.9983999729);6q5p(1);4h8m(0.9988999963);3r46(1);6q5j(1);6q5h(0.9528999925);6q5i(0.9542000294);7qdk(0.996999979);7bat(0.9929999709);7baw(1)...
null
4dzk(0)
null
3r47(1)
null
null
null
4dzl
2012-08-29
other
id:A,I,C,B,E,F,G,H,J,D,K,L;type:U;source:unknown;length:33;seq_nat:XGEIAAIKQEIAAIKKEIAAIKFEIAAIKQGYG;seq_unnat:(ACE)GEIAAIKQEIAAIKKEIAAIK(PHI)EIAAIKQGYG
3,543.95
P 21 21 2
102.761|108.441|41.608|90.00|90.00|90.00
X-RAY DIFFRACTION
Solid state peptide synthesis
J.M. Fletcher;A.L. Boyle;M. Bruning;G.J. Bartlett;T.L. Vincent;N.R. Zaccai;C.T. Armstrong;E.H. Bromley;P.J. Booth;R.L. Brady;A.R. Thomson;D.N. Woolfson
"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology", ACS Synth Biol, 1, 240-250
10.1021/sb300028q|23651206||2161-5063|
US
A de novo designed coiled coil cc-tri
de novo protein
null
null
3r4h(0.9800000191);3r4a(0.9821000099);8b45(0.9801999927);6i1j(0.9664000273);4h8g(0.9983999729);4dzn(0.9805999994);4dzm(0.9750000238);3r3k(0.991599977);6q5n(0.9772999883);7qdk(0.9757000208);3r48(0.9794999957);4h8m(0.9786999822);6q5j(0.9805999994);8bfe(0.9782000184);3r46(0.9789999723);6q5p(0.9811999798);4dzk(0.9761999846...
null
4dzl(0)
null
4h8g(0.9983999729)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2720;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.4...
null
4dzm
2012-08-29
other
id:A,B;type:U;source:unknown;length:33;seq_nat:XGEIAALKQEIAALKKENAALKFEIAALKQGYY;seq_unnat:(ACE)GEIAALKQEIAALKKENAALK(PHI)EIAALKQGYY
3,651.017
P 62
23.509|23.509|189.598|90.00|90.00|120.00
X-RAY DIFFRACTION
Solid state peptide synthesis
J.M. Fletcher;A.L. Boyle;M. Bruning;G.J. Bartlett;T.L. Vincent;N.R. Zaccai;C.T. Armstrong;E.H. Bromley;P.J. Booth;R.L. Brady;A.R. Thomson;D.N. Woolfson
"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology", ACS Synth Biol, 1, 240-250
10.1021/sb300028q|23651206||2161-5063|
US
A de novo designed coiled coil cc-di
de novo protein
null
null
4dzn(0.9972000122);4dzl(0.9724000096);4h8f(0.9897000194);4h7r(0.9779000282);4h8g(0.9581000209);8b45(0.9539999962);6i1j(0.9570999742);6q5p(0.9581000209);3r4h(0.9570999742);3r4a(0.9563999772);3r48(0.9707000256)
null
4dzm(0)
null
4dzn(0.9972000122)
null
1.20.5.510;1.20.5.420;6.10.250.1210;1.20.5.1610;1.20.5.460;1.20.5.1450;1.20.5.740;1.20.5.170;1.20.5.220;1.20.5.110;1.20.5.590
null
4dzn
2012-08-29
other
id:A,B,C;type:U;source:unknown;length:33;seq_nat:XGEIAALKQEIAALKKEIAALKFEIAALKQGYY;seq_unnat:(ACE)GEIAALKQEIAALKKEIAALK(PHI)EIAALKQGYY
3,650.072
P 21 21 21
24.723|40.943|87.430|90.00|90.00|90.00
X-RAY DIFFRACTION
Solid state peptide synthesis
J.M. Fletcher;A.L. Boyle;M. Bruning;G.J. Bartlett;T.L. Vincent;N.R. Zaccai;C.T. Armstrong;E.H. Bromley;P.J. Booth;R.L. Brady;A.R. Thomson;D.N. Woolfson
"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology", ACS Synth Biol, 1, 240-250
10.1021/sb300028q|23651206||2161-5063|
US
A de novo designed coiled coil cc-pil
de novo protein
null
null
4dzm(0.9585999846);4dzl(0.9768999815);4h8f(0.9603999853);4h7r(0.9703999758)
null
4dzn(0)
null
4dzl(0.9768999815)
null
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.1...
null
4dzu
2012-05-02
other
id:A;type:D;source:Synthetic construct;length:200;seq_nat:SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLGGSGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLGGSGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL;seq_unnat:SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNY...
22,246.82
C 2 2 21
77.293|121.208|59.259|90.000|90.000|90.000
X-RAY DIFFRACTION
null
L.M. Johnson;D.E. Mortenson;H.G. Yun;W.S. Horne;T.J. Ketas;M. Lu;J.P. Moore;S.H. Gellman
"Enhancement of alpha-helix mimicry by an alpha / beta-peptide foldamer via incorporation of a dense ionic side-chain array", J.Am.Chem.Soc., 134, 7317-7320
10.1021/ja302428d|22524614|0004|0002-7863|JACSAT
US
Complex of 3-alpha bound to gp41-5
de novo protein;viral fusion
4dzv(392);6vfl(93);6vl5(93);6vfk(91)
3o3x(392);3o40(392);3o42(392);3o43(392);2cmr(353);2xra(353);3mac(351);3ma9(351);1f23(150);3cp1(140);9fed(140);3cyo(139);1df4(134);1df5(134);1szt(134);1qr9(132);2ot5(132);1dlb(132);3p30(132);1k33(131);1k34(131);1i5x(131);1i5y(131);1env(130);1qr8(128);3k9a(112);2kp8(104);9bnl(102);9bnp(102);9bnk(102);9f02(102);9evz(102);...
4dzv(0.9502999783)
3f4y(1);3g7a(0.9502000213);3f4z(0.9625999928);3o3z(0.9517999887)
4dzv(392)
3o3x(392)
4dzv(0.9502999783)
3f4y(1)
6.10.250.3050;6.10.250.1320;1.20.5.430;6.10.250.810;4.10.170.10;1.10.287.690;1.20.58.410;6.10.140.1450;6.10.140.1740;1.10.287.140;1.20.5.470;1.10.287.310;1.20.5.520;1.20.5.730;6.10.250.10;1.10.287.1890;1.20.140.10;1.10.287.850;6.10.250.1780;6.10.140.820;1.20.58.220;6.10.250.3080;1.10.287.170;1.20.5.460;1.20.5.300;6.10....
null
4dzv
2012-05-02
other
id:A;type:D;source:Synthetic construct;length:200;seq_nat:SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLGGSGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLGGSGGSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL;seq_unnat:SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILSGGSGGWMEWDREINNY...
22,246.82
P 21 21 21
47.950|57.302|102.036|90.000|90.000|90.000
X-RAY DIFFRACTION
null
L.M. Johnson;D.E. Mortenson;H.G. Yun;W.S. Horne;T.J. Ketas;M. Lu;J.P. Moore;S.H. Gellman
"Enhancement of alpha-helix mimicry by an alpha / beta-peptide foldamer via incorporation of a dense ionic side-chain array", J.Am.Chem.Soc., 134, 7317-7320
10.1021/ja302428d|22524614|0004|0002-7863|JACSAT
US
Complex of 4-alpha/beta bound to gp41-5
de novo protein;viral fusion;beta amino acid
4dzu(392);6vfl(93);6vl5(93);6vfk(91)
3o3x(392);3o40(392);3o42(392);3o43(392);2cmr(353);2xra(353);3mac(351);3ma9(351);1f23(150);3cp1(140);9fed(140);3cyo(139);1df4(134);1df5(134);1szt(134);1qr9(132);2ot5(132);1dlb(132);3p30(132);1k33(131);1k34(131);1i5x(131);1i5y(131);1env(130);1qr8(128);3k9a(112);2kp8(104);9bnl(102);9bnp(102);9bnk(102);9f02(102);9evz(102);...
4dzu(0.9571999907)
3o43(0.9677000046);3f4z(0.9624000192);3o40(0.9636999965);3o42(0.9603000283);3f4y(0.9539999962);3vie(0.9580000043);3ma9(0.9530000091)
4dzu(392)
3o3x(392)
4dzu(0.9571999907)
3o43(0.9677000046)
1.10.287.110;1.10.287.690;6.10.140.1450;1.10.287.310;1.20.140.10;1.10.287.850;6.10.140.820;1.20.58.220;1.20.5.460;1.10.287.170;1.20.5.300;6.10.280.160;1.10.287.1120;1.10.287.660;6.10.140.630;1.10.287.70;1.20.1440.150;1.20.5.1450;1.10.287.210;6.10.140.1460;1.10.287.230;6.10.250.1010;6.10.140.1320;1.10.287.540;1.10.287.1...
null
4e88
2012-04-11
other
id:A;type:D;source:synthetic construct;length:210;seq_nat:MGGRALRVLVDMDGVLADVEGGLLRKFRARFPDQPFIALEDRRGYKACEQYGRLRPGLSEKARSIAESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPHKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPCGSLEHHHHHH;seq_unnat:(MSE)GGRALRVLVD(MSE)DGVLADVEGGLLRKFRARFPDQP...
24,209.996
C 1 2 1
87.994|61.745|59.384|90.000|128.950|90.000
X-RAY DIFFRACTION
null
A. Kuzin;M. Su;J. Seetharaman;X. Xiao;S. Sahdev;C. Ciccosanti;F. Richter;J.K. Everett;T.B. Acton;G.T. Montelione;J.F. Hunt;L. Tong
To be published
||||
null
Crystal structure of de novo designed cysteine esterase ech13, northeast structural genomics consortium target or51
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;hydrolase;nesg
null
3u19(447);3u13(447);1q91(399);1q92(399);1mh9(399);1z4i(397);1z4j(397);1z4k(397);1z4l(397);2jau(397);1z4m(397);2jaw(397);1z4p(397);1z4q(397);2i7d(261);2jar(260);2jao(260);3bwv(59)
null
3u19(1);2jau(0.9659000039)
4e88(0)
3u19(447)
8gaq(0.3551000059)
3u19(1)
3.40.50.1980;3.40.50.1000
null
4ess
2012-06-13
other
id:A;type:U;source:unknown;length:169;seq_nat:MARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTALGAWVGGLPAEAVLRVMLEEIKKAPDTLEVTGVHGTEKSAEAARRARLEHHHHHH;seq_unnat:MARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSA...
17,705.252
C 1 2 1
114.698|46.074|30.179|90.00|102.84|90.00
X-RAY DIFFRACTION
null
S. Rajagopalan;C. Wang;K. Yu;A.P. Kuzin;F. Richter;S. Lew;A.E. Miklos;M.L. Matthews;J. Seetharaman;M. Su;J.F. Hunt;B.F. Cravatt;D. Baker
"Design of activated serine-containing catalytic triads with atomic-level accuracy", Nat.Chem.Biol., 10, 386-391
10.1038/nchembio.1498|24705591||1552-4450|
US
Crystal structure of e6d/l155r variant of de novo designed serine hydrolase osh55, northeast structural genomics consortium (nesg) target or187
de novo protein, hydrolase;protein structure initiative;de novo protein;structural genomics;psi-biology;osh55 mutant e6d/l159r;hydrolase;northeast structural genomics consortium (nesg) target or187;serine hydrolase
4etj(320);4k0c(315);4kyb(313);4j4z(310)
4etk(312);2dx6(268);2x47(87);1vhu(78);3q6z(76);1spv(75);2bfq(70);2bfr(70);1hjz(70);3q71(62)
null
null
4etj(320)
4etk(312)
3v45(0.9402999878)
2dx6(0.8963000178)
3.40.220.10;3.40.50.300;3.40.220.20;3.40.50.2300;3.40.50.1980
null
4etj
2012-06-13
other
id:A;type:D;source:artificial gene;length:169;seq_nat:MARIRHVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTALGAWVGGLPAEAVLRVMLEEIKKAPDTLEVTGVHGTEKSAEAARRALLEHHHHHH;seq_unnat:MARIRHVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLET...
17,684.277
P 43 21 2
65.930|65.930|89.260|90.00|90.00|90.00
X-RAY DIFFRACTION
null
S. Rajagopalan;C. Wang;K. Yu;A.P. Kuzin;F. Richter;S. Lew;A.E. Miklos;M.L. Matthews;J. Seetharaman;M. Su;J.F. Hunt;B.F. Cravatt;D. Baker
"Design of activated serine-containing catalytic triads with atomic-level accuracy", Nat.Chem.Biol., 10, 386-391
10.1038/nchembio.1498|24705591||1552-4450|
US
Crystal structure of e6h variant of de novo designed serine hydrolase osh55, northeast structural genomics consortium (nesg) target or185
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg
4ess(318);4j4z(316);4k0c(310);4kyb(307)
4etk(314);2dx6(269);2x47(86);1vhu(78);1spv(77);3q6z(76);2bfq(70);2bfr(70);1hjz(70);3q71(62)
null
null
4ess(318)
4etk(314)
4j4z(0.8870000243)
2dx6(0.9329000115)
null
null
4f2v
2012-05-30
other
id:A,B;type:D;source:artificial gene;length:275;seq_nat:MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHLLLWFLQGDTNIAYLHENNVTILDEWADENGDLGPVHGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMANAPSHAFFQFYVADGKLSCQLYARSEDVFLSLPFAIASGALLVHMMAQQCDLEVGDFVMTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI...
31,624.697
P 21 21 21
51.447|83.591|126.617|90.000|90.000|90.000
X-RAY DIFFRACTION
null
S. Rajagopalan;C. Wang;K. Yu;A.P. Kuzin;F. Richter;S. Lew;A.E. Miklos;M.L. Matthews;J. Seetharaman;M. Su;J.F. Hunt;B.F. Cravatt;D. Baker
"Design of activated serine-containing catalytic triads with atomic-level accuracy", Nat.Chem.Biol., 10, 386-391
10.1038/nchembio.1498|24705591||1552-4450|
US
Crystal structure of de novo designed serine hydrolase, northeast structural genomics consortium (nesg) target or165
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg;de novo design
null
1bq1(539);1tys(539);1bq2(539);3bgx(539);1f4d(539);1jut(537);2a9w(537);1kce(537);1f4b(537);1f4c(537);1jtu(537);3b9h(537);1aob(537);1f4e(537);1kzi(537);1zpr(537);1f4f(537);1jtq(537);1f4g(537);1tsn(537);2kce(537);3bhl(537);1tls(537);3tms(537);2ftq(537);2bbq(537);3bhr(537);1tsd(537);1trg(537);1bid(537);1tdu(537);1bdu(537);...
null
null
4f2v(0)
1bq1(539)
8prb(0.3481000066)
2g8x(0.9404000044)
null
null
4fzp
2013-12-11
other
id:A,B;type:N;source:Methanothermobacter thermautotrophicus;length:83;seq_nat:SNALDCRERIEKDLEDLEKELMEMKSIKLSDDEEAVVERALNYRDDSVYYLEKGDHITSFGCITYAEGLTDSLRMLHRIIEG;seq_unnat:SNALDCRERIEKDLEDLEKELMEMKSIKLSDDEEAVVERALNYRDDSVYYLEKGDHITSFGCITYAEGLTDSLRMLHRIIEG
9,542.686
P 21 21 21
44.032|46.929|65.756|90.00|90.00|90.00
X-RAY DIFFRACTION
null
L. Zhou;M. Bosscher;C. Zhang;S. Ozcubukcu;L. Zhang;W. Zhang;C.J. Li;J. Liu;M.P. Jensen;L. Lai;C. He
"A protein engineered to bind uranyl selectively and with femtomolar affinity", Nat Chem, 6, 236-241
10.1038/nchem.1856|24557139|0353|1755-4330|
UK
Crystal structure of the uranyl binding protein complexed with uranyl
uranyl binding;unknown function
null
null
null
null
null
null
null
null
null
null
4g1a
2012-12-05
other
id:A,B,C;type:U;source:unknown;length:32;seq_nat:QIAALEQKIAALEQKCAACEQKIAALEQKGGY;seq_unnat:QIAALEQKIAALEQKCAACEQKIAALEQKGGY
3,422.966
C 1 2 1
30.762|35.204|64.123|90.00|97.49|90.00
X-RAY DIFFRACTION
Peptide synthesis was done using an applied biosystems 433a and purified on a preparative c18 reverse phase hplc
D.V. Zaytsev;V.A. Morozov;J. Fan;X. Zhu;M. Mukherjee;S. Ni;M.A. Kennedy;M.Y. Ogawa
"Metal-binding properties and structural characterization of a self-assembled coiled coil: Formation of a polynuclear Cd-thiolate cluster", J.Inorg.Biochem., 119C, 1-9
10.1016/j.jinorgbio.2012.10.010|23160144|0525|0162-0134|JIBIDJ
US
Metal-binding properties of a self-assembled coiled coil: formation of a polynuclear cd-thiolated cluster
metallopeptide complexes;polynuclear metal-binding;helical bundles;self-assembly;metal binding protein;cd(ii)
null
null
null
null
4g1a(0)
null
5kb0(0.8981999755)
null
1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;6.10.250.1290;1.20.5.460;1.20.5.740;1.20.5.170;1.20.5.100;1.20.5.70;1.20.5.510;6.10.250.1330;6.10.250...
null
4g3b
2012-10-31
other
id:A,B;type:U;source:unknown;length:26;seq_nat:GNADEXYKELEDXQERLRKXRKKLRS;seq_unnat:GNADE(6FL)YKELED(6FL)QERLRK(6FL)RKKLRS
3,533.529
P 21 21 2
30.819|39.251|41.233|90.000|90.000|90.000
X-RAY DIFFRACTION
Synthesized
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains", Protein Sci., 21, 1705-1715
10.1002/pro.2150|22930450|0795|0961-8368|PRCIEI
US
Crystal structure of the de novo designed fluorinated peptide alpha4f3d
de novo designed;coiled-coil;alpha helix;fluorinated protein;de novo protein
null
null
3twe(0.9965000153);3twf(0.9822999835);4g4l(0.99150002);4g4m(0.9505000114)
null
null
null
3twe(0.9965000153)
null
1.20.5.420;1.20.5.2620;1.20.5.1450;6.10.250.500;6.10.250.880;6.10.250.2060;6.10.250.1090;6.10.250.1210;6.10.250.1020;6.10.250.490;1.20.5.110;1.20.5.460;1.20.5.740;1.20.5.170;1.20.5.100;1.20.5.510;6.10.250.2580;6.10.250.320;1.20.5.220;6.10.250.410;1.20.5.140
null
4g4l
2012-10-31
other
id:A,B;type:U;source:unknown;length:27;seq_nat:GNADEXYKEXEDXQERXRKXRKKXRSG;seq_unnat:GNADE(0JY)YKE(0JY)ED(0JY)QER(0JY)RK(0JY)RKK(0JY)RSG
3,350.914
P 21 21 2
31.307|37.417|40.761|90.000|90.000|90.000
X-RAY DIFFRACTION
null
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains", Protein Sci., 21, 1705-1715
10.1002/pro.2150|22930450|0795|0961-8368|PRCIEI
US
Crystal structure of the de novo designed peptide alpha4tba6
de novo designed;coiled-coil;alpha helix;nonnatural amino acid;de novo protein
null
null
3twe(0.9509999752);4g3b(0.9524999857)
null
null
null
4g3b(0.9524999857)
null
null
null
4g4m
2012-10-31
other
id:A,B;type:U;source:unknown;length:27;seq_nat:GNADEXYKEXEDXQERLRKLRKKLRSG;seq_unnat:GNADE(6FL)YKE(6FL)ED(6FL)QERLRKLRKKLRSG
3,590.581
I 41
49.581|49.581|41.569|90.000|90.000|90.000
X-RAY DIFFRACTION
null
B.C. Buer;J.L. Meagher;J.A. Stuckey;E.N. Marsh
"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains", Protein Sci., 21, 1705-1715
10.1002/pro.2150|22930450|0795|0961-8368|PRCIEI
US
Crystal structure of the de novo designed fluorinated peptide alpha4f3(6-13)
de novo designed;coiled-coil;alpha helix;fluorinated protein;de novo protein
null
null
4g3b(1);3twe(1);4g4l(0.9937000275);3twg(0.9745000005);3twf(0.9735000134);8qac(0.950600028)
null
null
null
4g3b(1)
null
6.10.250.1090;6.10.250.2370;6.10.250.1210;1.20.5.420;1.20.5.510;1.20.5.460;1.20.5.1450;6.10.250.490;1.20.5.740;1.20.5.170;1.20.5.220;6.10.250.270;6.10.250.500;1.20.5.100;1.20.5.110;1.20.5.140;6.10.250.740
null
4gmr
2012-08-29
other
id:A,B;type:D;source:synthetic construct;length:171;seq_nat:MSELGKRLIEAAENGNKDRVKDLLENGADVNASDSDGKTPLHLAAENGHKEVVKLLLSQGADPNAKDSDGKTPLHLAAENGHKEVVKLLLSQGADPNAKDSDGKTPLHLAAENGHKEVVKLLLSQGADPNTSDSDGRTPLDLAREHGNEEVVKLLEKQGGWLEHHHHHH;seq_unnat:MSELGKRLIEAAENGNKDRVKDLLENGADVNASDSDGKTPLHLAAENGHKEVVKLLLSQGADPNAKDSDGKTPLHLAAEN...
18,184.082
P 1 21 1
52.114|43.592|69.942|90.000|93.100|90.000
X-RAY DIFFRACTION
null
J.A. Fallas;G. Ueda;W. Sheffler;V. Nguyen;D.E. McNamara;B. Sankaran;J.H. Pereira;F. Parmeggiani;T.J. Brunette;D. Cascio;T.R. Yeates;P. Zwart;D. Baker
"Computational design of self-assembling cyclic protein homo-oligomers", NAT.CHEM., 9, 353-360
10.1038/nchem.2673|28338692||1755-4330|
UK
Crystal structure of engineered protein. northeast structural genomics consortium target or266
northeast structural genomics consortium;protein structure initiative;or266;psi-biology;de novo protein;nesg
4hb5(331);4gpm(318);5hry(310);4hqd(310);5eil(267);5kba(263);5hs0(250);4qfv(204);2xee(199);2xeh(196);4o60(191);7z71(190);9s60(189);6fpa(188);6fpb(188);7b4t(187);6fp9(187);6c9k(187);7z7e(186);7b4w(186);7z7c(186);4j7w(186);4j8y(186);9gtk(186);8ve7(186);8v9o(186);9g8i(184);7zyu(184);5kng(184);5knh(184);5le9(184);5op3(183);...
3zu7(191);2p2c(186);3noc(185);3nog(182);4f6r(181);4dx6(180);4dx7(180);9fhc(180);2j8s(180);9fhg(180);9fhj(180);9hao(180);9hci(180);4dx5(180);2y1l(179);1svx(178);2bkk(177);4drx(176);2v5q(175);9kcq(175);9kbu(175);3q9n(167);3q9u(167);3zuv(139);2v4h(139);2l6b(138);2xzt(138);2y0b(136);2xzd(135);3hg0(134);1awc(132);1n11(128);...
null
null
4hb5(331)
3zu7(191)
5hry(0.9458000064)
3aji(0.8891999722)
1.25.40.20;1.10.10.2400;1.10.220.10
null
4gpm
2012-09-05
other
id:A,B;type:D;source:synthetic construct;length:171;seq_nat:MSELGKRLIEAAENGNKDRVKDLIENGADVNASDSDGRTPLHHAAENGHKEVVKLLISKGADVNAKDSDGRTPLHHAAENGHKEVVKLLISKGADVNAKDSDGRTPLHHAAENGHKEVVKLLISKGADVNTSDSDGRTPLDLAREHGNEEVVKLLEKQGGWLEHHHHHH;seq_unnat:MSELGKRLIEAAENGNKDRVKDLIENGADVNASDSDGRTPLHHAAENGHKEVVKLLISKGADVNAKDSDGRTPLHHAAEN...
18,352.297
P 21 21 21
48.086|56.824|105.595|90.000|90.000|90.000
X-RAY DIFFRACTION
null
J.A. Fallas;G. Ueda;W. Sheffler;V. Nguyen;D.E. McNamara;B. Sankaran;J.H. Pereira;F. Parmeggiani;T.J. Brunette;D. Cascio;T.R. Yeates;P. Zwart;D. Baker
"Computational design of self-assembling cyclic protein homo-oligomers", NAT.CHEM., 9, 353-360
10.1038/nchem.2673|28338692||1755-4330|
UK
Crystal structure of engineered protein. northeast structural genomics consortium target or264
northeast structural genomics consortium;structural genomics;psi-biology;de novo protein;nesg
4hqd(332);4hb5(329);4gmr(316);5kba(291);5hry(282);5hs0(278);5eil(263);4qfv(209);4o60(198);2xee(195);2xeh(192);9s60(189);7z71(186);6fpa(184);6fpb(184);4j7w(184);7z7e(182);7z7c(182);4j8y(182);6c9k(182);7b4w(181);7b4t(181);9gtk(181);6fp9(181);8ve7(181);8v9o(181);7ujj(180);5le9(180);9g8i(179);7zyu(179);9epa(179);9fe1(179);...
3zu7(185);2p2c(181);3noc(181);3nog(177);4dx6(175);4dx7(175);9fhc(175);2j8s(175);2y1l(175);9fhg(175);4f6r(175);9fhj(175);9hao(175);9hci(175);4dx5(175);1svx(173);2bkk(172);9kcq(171);9kbu(171);2v5q(170);4drx(170);3q9n(162);3q9u(162);2l6b(144);2xzt(132);3zuv(132);2v4h(132);1awc(132);2y0b(130);2xzd(129);3hg0(127);3twt(121);...
5kba(0.9898999929);5hs0(0.9848999977);5eil(0.9528999925);5hry(0.9531999826);6fpb(0.9690999985);7z7e(0.9664999843);7z72(0.951399982);6fpa(0.956099987);7b4w(0.9585000277);5le8(0.9585000277);4qfv(0.9549999833);5knh(0.9516000152);5le7(0.9611999989);2xee(0.9519000053);7z71(0.9656999707);5kng(0.9681000113);7z7c(0.9611999989)...
null
4hqd(332)
3zu7(185)
5kba(0.9898999929)
2y1l(0.9283000231)
1.25.40.290;1.25.40.750;1.25.60.10;1.25.40.580;1.25.10.10;1.25.40.180;1.25.40.10;1.25.40.320;1.25.40.350;1.25.40.20
null
4gvw
2012-09-12
other
id:A;type:U;source:unknown;length:201;seq_nat:MEVLFEAKVGDITLKLAQGDITQYPAKAIVNAANKRLEHGGGVAYAIAKACAGDAGLYTEISKKAMREQFGRDYIDHGEVVVTPAMNLEERGIKYVFHTVGPICSGMWSEELKEKLYKAFLGPLEKAEEMGVESIAFPAVSAGIYGCDAEKVVETSLEAVKNFKGSAVKEVAEVHGARKSAEVALKVFERSLEHHHHHH;seq_unnat:MEVLFEAKVGDITLKLAQGDITQYPAKAIVNAANKRLEHGGGVAYAIAKACAGDAGLYTEISKK...
21,729.865
I 2 2 2
55.644|62.052|107.067|90.000|90.000|90.000
X-RAY DIFFRACTION
null
A. Kuzin;S. Lew;J. Seetharaman;S. Rajagopalan;J.K. Everett;T.B. Acton;G.T. Montelione;L. Tong;J.F. Hunt
To be published
||||
null
Three-dimensional structure of the de novo designed serine hydrolase 2bfq_3, northeast structural genomics consortium (nesg) target or248
de novo protein, hydrolase;protein structure initiative;northeast structural genomics consortium (nesg);structural genomics;psi-biology;hydrolase;de novo protein
null
null
null
1vhu(0.9918000102)
null
null
4etj(0.6200000048)
1vhu(0.9918000102)
3.40.50.1970;3.40.50.2300;3.40.50.1980;3.40.220.10
null
4h7r
2014-02-05
other
id:A,B,C,D;type:U;source:unknown;length:33;seq_nat:XGEIKAIAQEIKAIAKEIKAIAWEIKAIAQGYX;seq_unnat:(ACE)GEIKAIAQEIKAIAKEIKAIAWEIKAIAQGY(NH2)
3,398.045
P 21 21 21
36.630|38.230|88.740|90.00|90.00|90.00
X-RAY DIFFRACTION
null
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 4-helix coiled coil cc-hex-ii
none;de novo peptide;c-terminal amidation;4-helix coiled coil;n-terminal acetylation;de novo protein
null
null
4h8f(0.9736999869);3r48(0.9975000024);6q5s(0.97299999);4dzm(0.9750999808);4dzn(0.9975000024);4dzl(0.997600019);8b45(0.9714999795);6q5p(0.9726999998);4h8g(0.9732000232);6q5n(0.965200007);4h8m(0.9689999819);3r46(0.97299999);3r3k(0.9718999863);6q5j(0.9743000269);6q5r(0.9707999825);8a3g(0.9650999904);4h8o(0.9743000269);3r4...
4kvt(0.9738000035);4kvv(0.97299999);4kvu(0.9720000029)
4h7r(0)
null
4dzl(0.997600019)
4kvt(0.9738000035)
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.470;1.20.5.3960;6.10.250.2370;1.10.287.210;6.10.250.1020;6.10.250.1210;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.950...
null
4h8f
2014-02-05
other
id:A,B;type:U;source:unknown;length:33;seq_nat:XGEIKAIAQEIKAIAKEIKAIAFEIKAIAQGYX;seq_unnat:(ACE)GEIKAIAQEIKAIAKEIKAIA(PHI)EIKAIAQGY(NH2)
3,484.906
P 41 2 2
46.670|46.670|94.060|90.00|90.00|90.00
X-RAY DIFFRACTION
Standard f-moc peptide synthesis
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 4-helix coiled coil cc-hex-ii- 22
de novo protein;n-terminal acetylation; c-terminal amidation;synthetic coiled coil peptide;cc-hex related
null
null
4h7r(0.9771000147);4h8g(0.9589999914);3r48(0.9728000164);6q5p(0.9589999914);3r3k(0.9589999914);6q5n(0.9589999914);3r46(0.9589999914);4h8m(0.9578999877);4dzn(0.9983999729);6q5j(0.9589999914);6q5s(0.9589999914);4dzm(0.9897000194);4dzl(0.9707999825);4h8o(0.9589999914);8a3g(0.9589999914);6q5r(0.9589999914);6q5q(0.953199982...
4kvt(0.99150002);4kvv(0.9589999914);4kvu(0.956799984)
4h8f(0)
null
4dzn(0.9983999729)
4kvt(0.99150002)
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2360;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250....
null
4h8g
2014-02-05
other
id:A,B,C,D,E,F,I,J,G,H,K,L;type:U;source:unknown;length:32;seq_nat:XGEIKALAQEIKALAKEIKALAFEIKALAQGX;seq_unnat:(ACE)GEIKALAQEIKALAKEIKALA(PHI)EIKALAQG(NH2)
3,321.732
C 2 2 21
51.990|126.800|127.530|90.00|90.00|90.00
X-RAY DIFFRACTION
Standard f-moc solid phase peptide synthesis
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 6-helix coiled coil cc-hex-il- 22
spiral/offset 6-straded coiled coil;n-terminal acetylation;de novo protein;c-terminal amidation
null
null
4h8f(1);6q5n(1);6q5p(1);4h7r(1);3r47(1);3r3k(1);3r48(1);3r46(1);4h8m(1);6q5h(0.9593999982);6q5j(1);6q5o(0.9805999994);6q5s(1);6q5i(0.9577000141);4h8o(1);4dzn(1);5eoj(0.9563000202);6q5r(1);5eon(0.9575999975);4dzm(0.9991000295);6q5q(0.9792000055);5vte(0.9575999975);4dzl(1);4dzk(1);8a3g(1);8b45(1);6i1j(0.9937000275);7qdk(...
4kvt(1);4kvu(1);4kvv(1)
4h8g(0)
null
6q5p(1)
4kvt(1)
6.10.250.770;6.10.250.1960;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.310;6.10.250.1560;1.20.5.700;6.10.250.500;6.10.250.200;6.10.250.2150;6.10.250.880;6.10.250.270;6.10.250.2720;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.400;6.10.250.1440;1.20.5.1610;6.10.250...
null
4h8l
2014-02-05
other
id:A,B,C,D,E,F;type:U;source:unknown;length:34;seq_nat:XGELKCICQELKAIAWELKAIAKEDKAIAQGAGX;seq_unnat:(ACE)GELKCICQELKAIAWELKAIAKEDKAIAQGAG(NH2)
3,429.061
P 21 2 21
31.540|54.330|98.280|90.00|90.00|90.00
X-RAY DIFFRACTION
Standard f-moc solid phase peptide synthesis
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 6-helix coiled coil cc-hex-d24-a5/7c
parallel;cc-hex;c-terminal amidation;n-terminal acetylation;hexameric coiled coil;de novo protein
null
null
4h8m(1);3r48(1);6q5k(1);4h8o(1);6q5j(1);6q5m(1);6q5l(0.9951000214);6q5i(0.9963999987);3r47(1);6q5h(1);6q5n(1);3r3k(1);8bcs(0.9678999782);3r46(1);4h8g(1);6q5p(1);4h7r(1);4h8f(0.9983000159);6eiz(0.9710000157);7qwc(0.9674000144);3r4a(0.9689000249);3r4h(0.9654999971);7qdk(0.9710000157);8bfe(0.9679999948);6xy0(0.9733999968)...
4kvv(1);4kvt(1);4kvu(1)
4h8l(0)
null
3r48(1)
4kvv(1)
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.740;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1.20.5.250;6.10.250.1410...
null
4h8m
2014-02-05
other
id:A,B;type:U;source:unknown;length:32;seq_nat:XGELKCICQELKAIAKELKAIAWEHKAIAQGX;seq_unnat:(ACE)GELKCICQELKAIAKELKAIAWEHKAIAQG(NH2)
3,323.99
H 3
31.700|31.700|132.040|90.00|90.00|120.00
X-RAY DIFFRACTION
Standard f-moc solid phase peptide synthesis
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 6-helix coiled coil cc-hex-h24-a5/7c
parallel;cc-hex;c-terminal amidation;n-terminal acetylation;disulfide bonds;de novo protein;6-stranded coiled coil
null
null
3r48(1);6q5n(0.9894000292);3r46(1);6q5j(1);3r3k(0.9955000281);6q5p(1);6q5s(1);6q5o(0.9792000055);3r47(0.9685000181);4h8g(1);4h7r(0.9944000244);6q5r(1);4h8o(1);8a3g(0.9894000292);3r4a(0.9983000159);4h8f(0.9955999851);6q5q(0.9781000018);5eon(0.9575999975);8qaa(1);8qac(0.9575999975);3r4h(0.993900001);8b45(0.9988999963);5e...
4kvv(0.9962000251);4kvt(1);4kvu(0.9977999926)
4h8m(0)
null
3r46(1)
4kvt(1)
6.10.250.770;1.20.5.420;1.20.5.2620;1.20.5.770;1.20.5.1450;1.20.5.700;6.10.250.500;6.10.250.1150;6.10.250.2150;6.10.250.200;6.10.250.880;1.20.5.3960;6.10.250.2720;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;1.20.5.1610;6.10.250.160;6.10.250.850;6.10.250.490;6.10.250.1590;6.10.250...
null
4h8o
2014-02-05
other
id:A,B,C,D,E,F;type:U;source:unknown;length:32;seq_nat:XGELKAIAQELKAIAYELKAIAKENKAIAQGX;seq_unnat:(ACE)GELKAIAQELKAIAYELKAIAKENKAIAQG(NH2)
3,212.78
P 21 21 2
50.880|111.050|35.980|90.00|90.00|90.00
X-RAY DIFFRACTION
Standard f-moc solid phase peptide synthesis
B. Chi;N.R. Zaccai;R.L. Brady;D.N. Woolfson
To be published
||||
null
Crystal structure of a parallel 6-helix coiled coil cc-hex-n24
parallel;cc-hex;c-terminal amidation;n-terminal acetylation;hexameric coiled coil;de novo protein
null
null
3r48(1);3r3k(1);3r46(1);6q5n(1);4h8m(1);6q5j(1);4h8g(1);6q5p(1);6q5s(1);6q5o(0.980700016);4h7r(1);3r47(0.9575999975);6q5r(1);8a3g(0.9986000061);4h8f(1);3r4a(0.9983999729);3r4h(0.9853000045);6q5q(0.9751999974);5eon(0.9575999975);8qaa(1);5eoj(0.9575999975);5vte(0.9563000202);8qac(0.9575999975);8b45(0.9973000288);8qab(1);...
4kvt(1);4kvv(1);4kvu(1)
4h8o(0)
null
3r48(1)
4kvt(1)
6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;1.20.5.470;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.160;6.10.250.850...
null
4hb1
1998-03-04
other
id:A;type:D;source:synthetic construct;length:109;seq_nat:SSEELLKQALQQAQQLLQQAQELAKKGGGEELLKQALQQAQQLLQQAQELAKKGGGGEELLKQALQQAQQLLQQAQELAKKGGGEELLKQALQQAQQLLQQAQELAKK;seq_unnat:SSEELLKQALQQAQQLLQQAQELAKKGGGEELLKQALQQAQQLLQQAQELAKKGGGGEELLKQALQQAQQLLQQAQELAKKGGGEELLKQALQQAQQLLQQAQELAKK
11,815.356
P 64 2 2
51.900|51.900|61.000|90.00|90.00|120.00
X-RAY DIFFRACTION
null
C.E. Schafmeister;S.L. LaPorte;L.J. Miercke;R.M. Stroud
"A designed four helix bundle protein with native-like structure", Nat.Struct.Biol., 4, 1039-1046
10.1038/nsb1297-1039|9406555|2024|1072-8368|NSBIEW
US
A designed four helix bundle protein
designed helical bundle
null
null
null
null
4hb1(0)
null
8d06(0.8568000197)
null
1.10.287.540;1.10.287.110;1.10.287.910;1.20.5.420;1.10.287.1060;6.10.250.440;6.10.140.870;1.10.287.470;6.10.250.2860;6.10.140.790;4.10.860.20;1.10.287.690;6.10.250.220;1.20.58.90;6.10.140.360;1.20.5.440;6.10.140.150
null
4hb5
2012-10-10
other
id:A,B;type:D;source:artificial gene;length:171;seq_nat:MSELGKRLIEAAENGNKDRVKDLLENGADPNASDSDGRTPLHYAAENGHKEIVKLLLSKGADPNAKDSDGRTPLHYAAENGHKEIVKLLLSKGADPNAKDSDGRTPLHYAAENGHKEIVKLLLSKGADPNTSDSDGRTPLDLAREHGNEEIVKLLEKQGGWLEHHHHHH;seq_unnat:MSELGKRLIEAAENGNKDRVKDLLENGADPNASDSDGRTPLHYAAENGHKEIVKLLLSKGADPNAKDSDGRTPLHYAAENGHKE...
18,475.42
P 1 21 1
56.977|45.469|63.152|90.000|107.170|90.000
X-RAY DIFFRACTION
null
J.A. Fallas;G. Ueda;W. Sheffler;V. Nguyen;D.E. McNamara;B. Sankaran;J.H. Pereira;F. Parmeggiani;T.J. Brunette;D. Cascio;T.R. Yeates;P. Zwart;D. Baker
"Computational design of self-assembling cyclic protein homo-oligomers", NAT.CHEM., 9, 353-360
10.1038/nchem.2673|28338692||1755-4330|
UK
Crystal structure of engineered protein. northeast structural genomics consortium target or267
protein structure initiative;northeast structural genomics consortium (nesg);structural genomics;psi-biology;de novo protein
4gpm(329);4gmr(328);4hqd(327);5hry(295);5eil(286);5kba(272);5hs0(258);4qfv(206);4o60(196);2xee(192);2xeh(189);9s60(185);7z71(183);6fpa(182);6fpb(182);4j7w(181);7z7e(179);7b4w(179);7z7c(179);7b4t(179);4j8y(179);9gtk(179);6fp9(179);6c9k(179);8v9o(179);8ve7(178);7ujj(177);5le9(177);9g8i(176);7zyu(176);9epa(176);9fe1(176);...
3zu7(183);2p2c(178);3noc(178);4dx6(173);4dx7(173);9fhc(173);2j8s(173);2y1l(173);9fhg(173);9fhj(173);3nog(173);9hao(173);9hci(173);4dx5(173);4f6r(172);1svx(170);2bkk(169);9kcq(168);9kbu(168);4drx(168);2v5q(166);3q9n(159);3q9u(159);2l6b(139);1awc(134);3zuv(131);2xzt(130);2v4h(130);2xzd(128);2y0b(128);3hg0(126);1n11(125);...
4gmr(0.9559999704);5eil(0.9519000053)
null
4gpm(329)
3zu7(183)
4gmr(0.9559999704)
3q9n(0.9147999883)
1.10.10.10;1.10.10.2400;1.25.40.70;1.10.220.10;1.25.10.10;1.25.40.20
null
4hqd
2012-11-14
other
id:A,B;type:D;source:synthetic construct;length:171;seq_nat:MSELGKRLIEAAENGNKDRVKDLIENGADVNASDSDGRTPLHYAAKEGHKEIVKLLISKGADVNAKDSDGRTPLHYAAKEGHKEIVKLLISKGADVNAKDSDGRTPLHYAAKEGHKEIVKLLISKGADVNTSDSDGRTPLDLAREHGNEEIVKLLEKQGGWLEHHHHHH;seq_unnat:MSELGKRLIEAAENGNKDRVKDLIENGADVNASDSDGRTPLHYAAKEGHKEIVKLLISKGADVNAKDSDGRTPLHYAAKE...
18,528.717
P 1 21 1
69.004|30.461|70.061|90.000|92.680|90.000
X-RAY DIFFRACTION
null
S. Vorobiev;M. Su;F. Parmeggiani;J. Seetharaman;P.-S. Huang;M. Maglaqui;R. Xiao;D. Lee;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt
To be published
||||
null
Crystal structure of engineered protein. northeast structural genomics consortium target or265
northeast structural genomics consortium;structural genomics;psi-biology;de novo protein;nesg;engineered protein
4gpm(329);4hb5(325);4gmr(305);5hry(271);5kba(271);5eil(261);5hs0(258);2xee(207);4qfv(205);2xeh(204);4o60(196);9s60(191);7z71(190);7b4t(190);6fpa(189);6fpb(189);7z7e(188);9gtk(188);7b4w(187);7z7c(186);4j7w(186);5le9(186);4j8y(185);6fp9(185);5kng(184);5knh(184);9g8i(183);9epa(183);9fe1(183);7ujj(183);8v9o(183);5lea(183);...
3noc(187);3zu7(184);2p2c(183);4dx6(179);4dx7(179);9fhc(179);1svx(179);2j8s(179);9fhg(179);4f6r(179);9fhj(179);3nog(179);9hao(179);9hci(179);4dx5(179);2y1l(178);2v5q(175);9kcq(175);9kbu(175);4drx(175);2bkk(172);3q9n(164);3q9u(164);2l6b(143);2xzt(134);1awc(134);2y0b(132);3zuv(132);2xzd(131);2v4h(131);3hg0(126);9khf(126);...
null
null
4gpm(329)
3noc(187)
6fpb(0.945299983)
3q9n(0.9156000018)
1.25.40.290;1.25.40.750;1.25.40.720;1.25.60.10;1.25.40.580;1.25.10.10;1.25.40.180;1.25.40.10;1.25.40.320;1.25.40.350;1.25.40.20
null
4hxt
2012-11-21
other
id:A;type:D;source:artificial gene;length:255;seq_nat:MNDVEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLQKLLTSTDSEVQKEAQRALENIKSGGWLEHHHHHH;seq_unnat:(MS...
26,073.201
C 1 2 1
95.493|31.941|72.543|90.000|90.780|90.000
X-RAY DIFFRACTION
null
J.A. Fallas;G. Ueda;W. Sheffler;V. Nguyen;D.E. McNamara;B. Sankaran;J.H. Pereira;F. Parmeggiani;T.J. Brunette;D. Cascio;T.R. Yeates;P. Zwart;D. Baker
"Computational design of self-assembling cyclic protein homo-oligomers", NAT.CHEM., 9, 353-360
10.1038/nchem.2673|28338692||1755-4330|
UK
Crystal structure of engineered protein. northeast structural genomics consortium target or329
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg
4rv1(440);4rzp(343);7r0r(205);7qnp(201)
3tpm(131);2c1m(131);3ve6(131);3l3q(131);3btr(131);1y2a(131);1ial(131);1ejl(131);3knd(131);1ejy(131);1pjm(131);1iq1(131);1pjn(131);3q5u(131);1q1s(131);1q1t(131);3oqs(131);3ukw(131);3ukx(131);3uky(131);3ukz(131);3ul0(131);3ul1(131);3rz9(131);9cle(131);9cl8(131);9clf(131);3uvu(131);9clg(131);3rzx(131)
null
null
4rv1(440)
3tpm(131)
4rv1(0.9466000199)
1bk5(0.787899971)
1.20.930.10;1.25.40.250;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.20.1050.10;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.25.40.580;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.10.10.2400;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.170;1.10.220.10;1.20.1440.250;1.25.40.180;1.20.58...
null
4ijb
2013-01-16
other
id:A;type:D;source:artificial gene;length:259;seq_nat:MPRYLKGWLEDVVQLSLRRPSVRASRQRPIISLNERILEFNKRNITAIIALYMRKSPSGLDVERDPIEYAKFMERYAVGLSIVTEEKYFNGSYETLRKIASSVSIPILMNDFIVKESQIDDAYNLGADTVALKVKILTERELESLLEYARSYGMEPLIEINDENDLDIALRIGARFIGIWSQDNETLEINKENQRKLISMIPSNVVKVAGGGISERNEIEELRKLGVNAFLIGESLMRNPEKIKELIELEHHHHHH;seq_unnat...
29,858.168
P 21 21 21
35.319|60.187|110.560|90.00|90.00|90.00
X-RAY DIFFRACTION
null
S. Vorobiev;M. Su;M.J. Bick;J. Seetharaman;S. Khare;M. Maglaqui;R. Xiao;D. Lee;A. Day;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;J. Hunt;L. Tong
To be published
||||
null
Crystal structure of engineered protein, northeast structural genomics consortium target or288
northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg;engineered protein
4a29(460);9mya(458);4lny(447);9myb(437);4lt9(431)
8w3y(472);8w3z(472);8w40(472);3tc6(458);3ud6(457);4a2s(457);3o6y(457);3tc7(456);3nxf(456);4a2r(451);1juk(446);1jul(446);1igs(446);3nyz(445);3nz1(445);1lbl(444);1a53(444);1lbf(444);3hoj(440);3uy8(426);3uxa(424);3uxd(424);3uy7(424);3uyc(414);3uzj(406);3uz5(406);2c3z(398);1j5t(108);1i4n(108);3qja(106);3t40(106);3t44(106);...
null
null
4a29(460)
8w3y(472)
9mya(0.9308999777)
4a2s(0.9377999902)
6.10.250.1960;3.20.20.10;3.20.20.390;3.20.20.380;3.20.20.150;6.10.250.1560;3.20.20.70;3.20.20.140;3.20.20.410;6.10.250.400;3.20.20.120;3.20.20.110;4.10.180.60;3.20.20.220;4.10.180.10;3.20.20.20;3.20.20.80;6.10.250.1110;6.10.250.2050;3.20.20.190;3.20.20.60;6.10.250.1990;6.10.250.2830;1.20.5.220;1.20.5.640;3.20.20.370
null
4ivh
2013-07-31
other
id:A;type:U;source:unknown;length:16;seq_nat:TAQKLVFFAEDAXKXY;seq_unnat:T(ORN)QKLVFFAED(ORN)(HAO)K(HAO)(4BF)
2,252.276
P 6 2 2
45.085|45.085|29.247|90.00|90.00|120.00
X-RAY DIFFRACTION
null
J.D. Pham;N. Chim;C.W. Goulding;J.S. Nowick
"Structures of beta-Amyloid Peptide Oligomers", J.Am.Chem.Soc.
|||1520-5126|JACSAT
US
Crystal structure of qklvffaed nonapeptide segment from amyloid beta incorporated into a macrocyclic beta-sheet template
de novo protein;amyloid oligomer
null
null
null
null
4ivh(0)
null
4ntr(0.5583000183)
null
null
null
4j4z
2013-03-06
other
id:A;type:D;source:synthetic construct;length:169;seq_nat:MARIRHVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTSWGAWVGGLPAEAVHRVMFEEIKKAPDTLEVTGVHGTEKSAEAYRRALLEHHHHHH;seq_unnat:(MSE)ARIRHVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLG...
18,018.221
C 1 2 1
69.906|66.771|38.102|90.00|100.06|90.00
X-RAY DIFFRACTION
null
A.P. Kuzin;S. Lew;S. Rajagopalan;M. Maglaqui;R. Xiao;D. Lee;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt
To be published
||||
null
Crystal structure of the improved variant of the evolved serine hydrolase, osh55.4_h1.2, bond with sulfate ion in the active site, northeast structural genomics consortium (nesg) target or301
unknown function;protein structure initiative;structural genomics;psi-biology;structural genomics, unknown function;serine hydrolase;northeast structural genomics consortium (nesg) target or301;osh55.4_h1.2
4etj(316);4k0c(308);4ess(308);4kyb(305)
4gvv(312);4etk(310);2dx6(265);2x47(82);1spv(76);3q6z(72);1vhu(71);4iqy(69);2bfq(63);2bfr(63);1hjz(63);3q71(58);4abk(57);4abl(57)
null
null
4etj(316)
4gvv(312)
4k0c(0.9088000059)
4gvv(0.9223999977)
null
null
4j7w
2013-08-14
other
id:A,B;type:D;source:synthetic construct;length:171;seq_nat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDNDGYTPLHLAASNGHLEIVEVLLKNGADVNASDLTGITPLHAAAATGHLEIVEVLLKHGADVNAYDNDGHTPLHLAAKYGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLN;seq_unnat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDNDGYTPLHLAASNGHLEIVEVLLKNGADVNASDLTG...
18,053.025
P 21 21 21
44.370|78.590|82.230|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M.A. Seeger;R. Zbinden;A. Flutsch;P.G. Gutte;S. Engeler;H. Roschitzki-Voser;M.G. Grutter
"Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity", Protein Sci., 22, 1239-1257
10.1002/pro.2312|23868333|0795|0961-8368|PRCIEI
US
E3_5 darpin l86a mutant
protein design;darpins;ankyrin repeat protein;de novo protein;unselected darpin
4j8y(340);8ql6(297);8ql5(297);8ql9(297);9u6a(297);8ql2(297);8ql3(297);9f8g(297);8qlb(297);8qla(297);8ql7(297);8ql8(297);8qea(297);8ql4(297);4dui(297);5oou(295);5oos(291);9fe2(287);9fe3(287);5op3(286);2bkg(285);7dng(284);7dnf(284);5lw2(281);6fp9(281);4ydw(280);5kng(280);5knh(280);8u1b(276);9dmi(276);5le9(272);7b4t(271);...
1svx(298);3nog(298);2y1l(297);4drx(297);3noc(296);2p2c(291);4f6r(289);4hna(289);4dx6(287);4dx7(287);9fhc(287);3zu7(287);9kcq(287);2bkk(287);2j8s(287);9kbu(287);9fhg(287);9fhj(287);9hao(287);9hci(287);4dx5(287);2v5q(284);3q9n(255);3q9u(255);3hg0(231);3zuv(231);2xzt(226);2xzd(226);2v4h(226);4grg(224);2y0b(224);1awc(192);...
4j8y(0.9778000116);1mj0(0.9689000249);6fp9(0.9516000152);4dui(0.9667999744);6fpa(0.9582999945);6fpb(0.9664999843);2xee(0.9588999748);7z7c(0.9654999971);9gtk(0.9603999853);7z72(0.9505000114);5oos(0.9516999722);5knh(0.9660999775);5lw2(0.9528999925);8aed(0.9562000036);4ydw(0.9718999863);5kng(0.9660000205);7z7e(0.962599992...
4hna(0.9650999904)
4j8y(340)
1svx(298)
4j8y(0.9778000116)
4hna(0.9650999904)
1.10.10.2400;1.25.40.70;1.10.220.10;1.25.40.90;1.25.10.10;1.25.40.20
null
4j8y
2013-08-14
other
id:A;type:D;source:synthetic construct;length:171;seq_nat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDNDGYTPLHLAASNGHLEIVEVLLKNGADVNASSLTGITPLHLAAATGHLEIVEVLLKHGADVNAYDNDGHTPLHLAAKYGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLN;seq_unnat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNATDNDGYTPLHLAASNGHLEIVEVLLKNGADVNASSLTGIT...
18,067.096
P 21 21 21
34.880|53.630|78.380|90.00|90.00|90.00
X-RAY DIFFRACTION
null
M.A. Seeger;R. Zbinden;A. Flutsch;P.G. Gutte;S. Engeler;H. Roschitzki-Voser;M.G. Grutter
"Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity", Protein Sci., 22, 1239-1257
10.1002/pro.2312|23868333|0795|0961-8368|PRCIEI
US
E3_5 darpin d77s mutant
protein design;ankyrin repeat;darpins;de novo protein;unselected darpin
4j7w(339);8ql6(297);8ql5(297);8ql9(297);9u6a(297);8ql2(297);8ql3(297);9f8g(297);8qlb(297);8qla(297);8ql7(297);8ql8(297);8qea(297);8ql4(297);4dui(297);5oou(295);5oos(291);9fe2(286);9fe3(286);2bkg(285);5op3(285);7dng(284);7dnf(284);5lw2(281);5kng(280);5knh(280);6fp9(280);4ydw(279);8u1b(276);9dmi(276);5le9(272);7b4t(271);...
1svx(297);2y1l(297);4drx(297);3nog(297);3noc(295);2p2c(291);4f6r(288);4hna(288);3zu7(287);2bkk(287);4dx6(286);4dx7(286);9fhc(286);9kcq(286);2j8s(286);9kbu(286);9fhg(286);9fhj(286);9hao(286);9hci(286);4dx5(286);2v5q(284);3q9n(255);3q9u(255);3zuv(232);3hg0(230);2xzt(227);2xzd(226);2y0b(226);2v4h(226);4grg(224);1awc(194);...
1mj0(0.9707999825);4j7w(0.9775000215);2xeh(0.9624999762);4ydw(0.9850999713);6fp9(0.9599000216);7z7c(0.9725000262);7zyu(0.9589999914);7b4t(0.9588000178);6fpb(0.9707000256);9gtk(0.972299993);5kng(0.9803000093);2xee(0.9656999707);9g8i(0.9505000114);6fpa(0.9541000128);7z72(0.9664000273);5le8(0.9747999907);8aed(0.9563000202...
4hna(0.9746000171)
4j7w(339)
1svx(297)
4ydw(0.9850999713)
4hna(0.9746000171)
1.10.10.2400;1.25.40.40;1.10.220.10
null
4jbc
2013-03-20
other
id:A,B;type:D;source:synthetic construct;length:327;seq_nat:MQTVTEPVGSYARAERPQDFEGFVWRLLNDGKEALPRNFRTSADALRAPEKKFHLDAAYVPSREGMDALHISGSSAFTPAQLKNVAAKLREKTAGPIYDVDLSQNSHGYLDGIPVEWYGERNWANLGKSQHEALADERHRLHAALHKTVYIAPLGKHKLPEGGEVRRVQKVQTNQEVAEAAGMRYFRIAATDGVWPTPENIDRFLAFYRTLPQDAWLHFHSHSGVGATTAFMVMTDMLKNPSVSLKDILYRQHEIGGFYY...
37,499.145
P 21 21 2
82.243|194.552|46.090|90.000|90.000|90.000
X-RAY DIFFRACTION
null
A. Kuzin;S. Lew;S. Rajagopalan;J. Seetharaman;M. Maglaqui;R. Xiao;D. Lee;J.K. Everett;T.B. Acton;G.T. Montelione;L. Tong;D. Baker;J.F. Hunt
To be published
||||
null
Crystal structure of the computationally designed serine hydrolase 3mmj_2, northeast structural genomics consortium (nesg) target or318
unknown function;northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;structural genomics, unknown function;serine hydrolase;nesg
null
2b4u(642);1u24(642);1u25(642);1u26(642);3mmj(640);3o3l(640);3moz(639);2b4o(637);2pt0(637);3d1o(637);3d1h(637);3d1q(637);2psz(637);2b4p(634);3f41(284)
null
2b4p(0.9819999933);2b4o(0.9818000197);3o3l(0.980700016);3moz(0.9799000025);1u26(0.9747999907)
4jbc(0)
2b4u(642)
9e9n(0.4289999902)
2b4p(0.9819999933)
3.90.190.10;3.30.70.1690
null