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100 | Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin IIFlavodoxin II Kinetics on DDAB-Modified BPGE. The kinetics of the redox process observed on DDAB-modified BPGE were studied to determine if flavodoxin II diffused in the DDAB films on the time scale of voltammogram acquisition. Only ... |
101 | Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin IIdiffusing in the surfactant film. This result was consistent with the kinetics observed for other proteins, like myoglobin and cytochrome c 30 . However, there are also examples of proteins that are immobile in surfactant films under... |
102 | Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin II± S3B Figure S4 .
S3BS412 mV. (S3B) Square wave voltammogram of flavodoxin II on DDAB-modified basal plane graphite electrodes showing the reduction potential of E 1 and E 2 . (S3C)Dependence of the cathodic peak signal intensity on ... |
103 | Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin II(29)
--
-500 ± 10 (pH 7)*
Redox titration with chemical
mediators (UV-visible
absorption spectroscopy)
(12)
--
-449 (pH 6)
-488 (pH 8.5)
Direct electrochemistry on
glassy carbon modified with
neomycin (Cyclic voltammet... |
104 | Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin II17.50 |
105 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRoot morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyon
Joelle Sasse
Lawrence Berkeley National Laboratory
1 Cyclotron Rd94720BerkeleyCAUSA
Joint Genome In... |
106 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRoot morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyon
Authors and affiliations: |
107 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonKeywordsBrachypodium distachyonParticle chemistry Particle size Pseudomonas fluorescens Rhizosphere Root exudation Root morphology Abstract Root morphology and exudation define a plants sphere of influence in soi... |
108 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyon2015), and alter the composition of microbial communities (Carson et al., 2007).Soils are often characterized by their particle size and mineralogy. Typical soil particles range from small (< 50 µm) to large (> 2... |
109 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyondistinct lettuce root weight and root lengths, as well as in distinct presence of some rhizosphere metabolites (Neumann et al., 2014). As this study was performed in soils with different chemistry, granule sizes... |
110 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyontaking into account soil structure and chemistry when studying plant -soil interactions.ResultsMetabolite sorption to substrates Different particle sizes and surface chemistries were chosen to investigate how roo... |
111 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonacetylcholine), other nitrogenous compounds (amino acids, nucleotides/nucleosides), as well as of comparatively polar compounds such as sugars(Table S2). We confirm that as expected, clay particles sorb a variety... |
112 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonIntroduction
Substrate diffusion rates
Altering particle size is expected to affect solute diffusion rates, and thus, may limit sorption. To investigate if exudation is limited by diffusion in our experimental... |
113 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonExudates were collected, and root and shoot weight, as well as root morphology were assessed. Plants were grouped according to their behavior in the different substrates: plants with weights and root morphology s... |
114 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRoot length and number was assessed for first order roots (primary and crown roots), second order roots (laterals of primary and crown roots), and higher order roots. The total root length correlated with particl... |
115 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonOverall, clay-grown plants were most similar to hydroponically-grown plants regarding tissue weight and root morphology. Plants grown in 3 mm glass beads or 4 mm sand had comparable fresh weight compared to the a... |
116 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonExudates were collected from plants grown in sterile conditions in the various substrates, to investigate whether the altered root morphology, and the various spatial exudation patterns resulted in an overall cha... |
117 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonMost of the variation for in situ exudates was explained by differences between exudates collected in clay, compared to other conditions, which is evident from a principal component analysis (Fig. 4). Similarly, ... |
118 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonIn situ big vs. small sand exudate profiles To further investigate differences of in situ collected exudates, metabolic profiles of the groups 'big beads', 'small beads', 'big sand', and 'small sand' were compare... |
119 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonIn situ charged vs. uncharged substrates exudate profiles To further examine the differences between clay-grown and hydroponically-grown in situ exudates, a multi variant test was used to compare metabolite abund... |
120 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonNext, a rhizobacterium (Pseudomonas fluorescens) was incubated on various substrates preincubated with defined medium, and optical density (OD) was determined after three days. Defined medium with different conce... |
121 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonNotably, the morphology of B. distachyon grown in glass beads or sand were not directly comparable: plants grown in 5 µm sand had higher root weight and total root length than plants grown in 0.5 mm glass beads. ... |
122 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFor glass bead-grown plants, the reduction in total root length was explained by a reduction in second order root length, whereas the primary order root length was reduced in all sizes smaller than 3 mm. These tr... |
123 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonhow plants respond to soil physiochemistry on a spatial and time scale. Multiple systems exist in which such experiments could be attempted, ranging from EcoFAB model systems to rhizotron designs (Grossmann et al... |
124 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonExudation across the root system B. distachyon exhibited significantly altered root morphology when grown in particles with various sizes, with root weight and root lengths differing between conditions. The exuda... |
125 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonWe used mass spectrometry imaging to investigate exudation across roots. This data cannot directly be compared to the root morphology and LC/MS data for technical reasons (see Methods) and the fact that the exuda... |
126 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonExudation profiles were also comparable between plants grown in clay, sand, or glass beads, when collected in vitro. This suggests that the physiochemical environment does not alter plant metabolism, as long as o... |
127 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRecently, it was suggested that root tips might detect the concentration of rhizosphere metabolites, altering root morphology and exudation accordingly (Canarini et al., 2019). Thus, claygrown plants should exhib... |
128 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonAbout 20% of compounds were distinct between hydroponic and clay exudates, and most of these compounds were reduced in abundance in the presence of clay. Among these compounds were organic acids, amino acids, nuc... |
129 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonInterestingly, three nitrogenous metabolites were higher in abundance in exudates of in situ clay-grown plants, two of which are organic acids, and a positively charged metabolite (orotic acid, 4acetaminobutyric ... |
130 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonIn soils, metabolite sorption to minerals can lower decomposition rates (Baldock and Skjemstad, 2000). Also, the amount of clay in soil is correlated with retention of labeled carbon in soils (Baldock and Skjemst... |
131 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonWe conclude that differently sized particles induce distinct root morphologies in B. distachyon. Root exudation was constant per root fresh weight, and the exudate metabolite profiles were robust across root morp... |
132 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonSorption test with defined medium
The various substrates were sterilized, and incubated at 24˚C for 8 hours with a 20 µm equimolar defined medium, encompassing a variety of chemical classes, among them amino aci... |
133 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonDiffusion experiment and exponential model
Pipettes with a 50 ml volume were sealed at the bottom with parafilm, placed vertically, 50 ml of substrate was added, and approximately 25 ml of 0.5x MS was added to i... |
134 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyon*12234156 8#0% (9: • ℎ => ) = 0.388 • % (>C.C•() D22%901E% *12234156 F5%22191%60 (9: . • ℎ => ) = 0.5 • % (>H.I•() Where x is the glass bead diameter in cm, e is the base of the natural logarithm, 0.388 or 0.5 ar... |
135 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonWeck jars (743, Glashaus Inc.) were rinsed five times with MilliQ water, sprayed with 70% v/v ethanol, treated with UV for 1 h in a laminar flow hood, and dried over night. The jars were filled with 150 ml of the... |
136 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRoot exudate collection
At 21 days after germination (21 dag), the medium in the jars was exchanged, and jars were incubated at 24˚C with 150 µmol m -2 s -1 illumination for 2 h ('in situ' treatment). Subsequent... |
137 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonMALDI Mass Spectrometry Imaging
Mass spectrometry imaging was used to determine if root exudate patterns varied across the root system. Brachypodium distachyon seeds were sterilized and germinated on 0.5 MS plat... |
138 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonMALDI matrix was prepared as follows: 10 mg ml -1 a-cyano-4-hydroxycinnamic acid (70990, Sigma Aldrich, St. Louis, MO, USA) and 10 mg ml -1 Super-DHB (50862, Sigma Aldrich, St. Louis, MO, USA) were dissolved in 7... |
139 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonMetabolites were chromatographically separated with a hydrophilic liquid interaction chromatography on a Poroshell 120 HILIC-z 2.7 µm, 2.1 mm x 150 mm (Ag683775-924, Agilent Technologies) and detected with a Q Ex... |
140 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonm/z, 70,000 resolution, 3e6 AGC target, 100 ms maximum ion transmission) with dd settings at 1e3 minimum AGC target, charges excluded above |8| and a 7 s dynamic exclusion window. Internal and external standards ... |
141 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonMetabolite identification and statistical analysis
Ion chromatograms corresponding to metabolites represented within our in-house standard library were extracted from LC/MS data with Metabolite Atlas (https://gi... |
142 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonRhizobacterium growth experiment
A selection of different substrates (3 mm glass beads, 4 mm sand, 4 mm clay) was incubated with 50 times concentrated defined medium (50x DM, see: "Sorption test with defined med... |
143 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonThe metabolite desorption experiment was performed by adding 2 cm 3 of clay pre-incubated with 50x or 0x DM to a 12-well plate in triplicates, followed by the addition of 2 ml of 0x DM. The plate was incubated fo... |
144 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure 4 | In situ and in vitro exudate metabolite profiles Principal component (PC) analysis of root exudate metabolite profiles collected in situ (A) or
Figure 5 | Distinct metabolites of in situ clay
Heatma... |
145 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonX-ray diffraction analysis of 4 mm clay, 4 mm sand, and 250 µm sand. Trace elements are indicated as being present in sand (S) or clay (C). (C) Jar setup, one jar per condition is depicted. Top panel, from left: ... |
146 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonOptical density (OD at 600 nm) of P. fluorescens (orange bars) grown in clay pre-incubated with 50x defined medium (DM, Clay +) or 0x DM (Clay -), or in supernatant of clay pre-incubated with 50x DM (SN +) or 0x ... |
147 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonData are means ± SEM, n>5. Significant differences are displayed as asterisks (*, p = 0.05) of substrates compared to hydroponic control (0, dashed line). Grey areas: plants with weight and root morphology distin... |
148 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure S7 |
S7ANOVA-Tukey test results Number of significantly different metabolites in pairwise comparisons of in situ collected exudates (A), in vitro collected exudates (B), and substrates incubated with defin... |
149 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure 3 :Figure 3 |
33Spatial Spatial exudation patterns Plants were incubated for 6 h to allow for exudation (A). A traced outline of the root is displayed (B). Distinct root-associated patterns of several ions... |
150 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure 6 :Figure 6 |Figure S1 |Figure S2 |Figure S3 |Figure S4 | |
151 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyon66S1S2S3S4Rhizobacterium Rhizobacterium grows on clayadsorbed metabolites Optical density (OD at 600 nm) of P. fluorescens grown on clay preincubated with 50x defined medium (DM, Clay +) or 0x DM (Clay -), or in ... |
152 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonand third order roots in green(SmartRoot, {Lobet:2011fl}). Quantification of root systems are displayed inFig. 2and Fig. S2. Scale bar: 3 cm. Correlation analysis of root parameters Correlation plots of various r... |
153 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure S5 :Figure S5 |
S5S5B. distachyon seedling exudation visualization Additional spatial exudation patterns Plants were incubated for 6 h to allow for exudation. Distinct rootassociated patterns of several ma... |
154 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure S8 :Figure S8 |Figure S9 |
S8S8S9Additional In situ and in vitro exudate metabolite profile analyses Principal component (PC) analysis of metabolite profiles of root exudates collected in situ or in vitro ... |
155 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonFigure S11 Figure S11 |
S11S11Additional data for rhizobacterium utilizes clay-adsorbed metabolites (A) Optical density (OD at 600 nm) of P. fluorescens (orange bars) grown in clay pre-incubated with 50x defined ... |
156 | Root morphology and exudate availability is shaped by particle size and chemistry in Brachypodium distachyonAcknowledgementsThe authors would like to thank Sarah Brecht and Matthew Chu for root morphology quantification, Nicholas Saichek for MALDI imaging support, and Marco Voltolini (LBNL) for X-Ray diffraction analys... |
157 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionParthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition
Reb... |
158 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMethods: Using metastatic human breast carcinoma cells MDA-MB-157, MDA-MB-436, and Bt-549, we measured the impact of NF-κB inhibitors parthenolide, costunolide, an... |
159 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition(Continued on next page)
Introduction
Microtubules have long been a target for cancer therapy given their critical and diverse cellular functions in intracellul... |
160 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMicrotubules can undergo phases of growth and shrinkage by modulating dynamic instability; however, stabilization of a subset of microtubules is necessary for cell... |
161 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionThe relationship between EMT, inflammation and cancer progression has received considerable attention in the last several years [13]. Given our recent discovery th... |
162 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionOur past research has used broad microtubule and actin disrupting agents as tools to determine the structure and function of McTNs. These tools have been useful to... |
163 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionImmunoblot
Cells were treated for six hours in growth media using a concentration range containing vehicle (0.1% dimethyl sulfoxide (DMSO)), Parth, Cost, ResV, Co... |
164 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionCell viability
Cells were seeded into 96-well microplates and treated in triplicate for six hours. CellTiter 96 AQ ueous One Solution (Promega, Madison, WI) was f... |
165 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionCell-electrode impedance attachment assay
Real-time monitoring of cell-substratum attachment was measured utilizing the xCELLigence RTCA SP real-time cell sensing... |
166 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionHuman breast carcinoma cell lines, MDA-MB-157, Bt-549 and MDA-MB-436 were treated with antiinflammatory or microtubule-targeting drugs to determine their effect on... |
167 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionComparison of the drug structures shows strong similarity between Parth and Cost, which differ only in an epoxide group, while the other compounds are structurally... |
168 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionSince normal cells are not generally as sensitive as tumor cells to sesquiterpene lactones due to low basal NF-κB activity, these compounds may target cancers in w... |
169 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionParthenolide and costunolide decrease detyrosinated tubulin without compromising the overall microtubule network While detyrosinated microtubules have been implica... |
170 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionOur previous research has identified detyrosinated αtubulin as a structural component of McTNs observed in detached cells. Additionally, increased McTN frequency h... |
171 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionDiscussion
Metastasis causes 90% of deaths from solid tumors; therefore, novel chemotherapeutic strategies that go beyond primary tumor treatment and inhibit meta... |
172 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionOur present results show that Parth and Cost can reduce McTNs by specifically targeting detyrosinated tubulin unlike traditional tubulin-targeted compounds, Tax an... |
173 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionChronic tissue damage and inflammation have been associated with tumor development as well as EMT [13,31,32], conditions that may promote persistent microtubule st... |
174 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionThere is growing evidence that select nonsteroidal anti-inflammatory drugs (NSAID) have anti-cancer properties, although the mechanisms are still being elucidated ... |
175 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionresistant lines [42] but has been studied to a lesser extent than Parth. Given detyrosinated tubulin's role in cell migration and reattachment, it is possible that... |
176 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMost clinical microtubule-targeted drugs bind directly to tubulin, resulting in an increase or decrease in the microtubule mass [43]. It has been noted that tubuli... |
177 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionConclusions
Based on the developing evidence, we propose that circulating tumor cell reattachment is facilitated by detyrosinated tubulin enriched McTNs [25,34]. ... |
178 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionAdditional file 2: Figure S2. (A) NF-κB -luciferase reporter adenovirus infected MDA-MB-436 shows that a four hour treatment of parthenolide (Parth; 10 μM, 25 μM) ... |
179 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionFigure 1
1Parthenolide and costunolide decrease detyrosinated tubulin in human breast carcinoma cells. (A) Bt-549 (N = 3) and MDA-MB-157 (N = 6) cells treated for ... |
180 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionFigure 2
2Tubulin detyrosination is independent of NF-κB activation. (A) NF-κB -luciferase reporter adenovirus infected MDA-MB-157 and Bt-549 show that a four-hour... |
181 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionFigure 4
4Parthenolide and costunolide decrease microtentacle (McTN) frequency and attachment. (A) Detached Bt-549 and MDA-MB-157 were pretreated for six hours and... |
182 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionAdditional file 3 :
3Figure S3. (A) Detached MDA-MB-436 were pretreated for six hours and suspended in drug containing media for blind McTN scoring. Parthenolide (... |
183 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionAcknowledgementsThis research was supported by R01-CA154624 and R01-124704 from the National Cancer Institute, KG100240 from the Susan G. Komen Foundation and an E... |
184 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMicrotubule dynamics as a target in oncology. A L Risinger, F J Giles, S L Mooberry, Cancer Treat Rev. 35Risinger AL, Giles FJ, Mooberry SL: Microtubule dynamics a... |
185 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionTubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. A Mialhe, L Lafanechere, I Treilleux, N Peloux, C Dumontet, A Bremond, M H Pan... |
186 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMotor-dependent microtubule disassembly driven by tubulin tyrosination. L Peris, M Wagenbach, L Lafanechere, J Brocard, A T Moore, F Kozielski, D Job, L Wordeman, ... |
187 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionNF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. ... |
188 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMicrotubule-interfering activity of parthenolide. A Miglietta, F Bozzo, L Gabriel, C Bocca, Chem Biol Interact. 149Miglietta A, Bozzo F, Gabriel L, Bocca C: Microt... |
189 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionCurcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. B... |
190 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionEpithelial cell dissemination and readhesion: analysis of factors contributing to metastasis formation in breast cancer. K Hekimian, S Meisezahl, K Trompelt, C Rab... |
191 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionActin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1. F Bartolini, N Ramalingam, G G Gundersen, Mole Biol Cell. 23Barto... |
192 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionTumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination cycle. Z J Sahab, M D Hall, Me Sung, Y Daksha... |
193 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionParthenolide, an NF-kappaB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer. I Sohma, Y Fujiwara, Y Sugita, A Yoshioka, M... |
194 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy again... |
195 | Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibitionMicrotubules as a target for anticancer drugs. M A Jordan, L Wilson, Nat Rev Cancer. 4Jordan MA, Wilson L: Microtubules as a target for anticancer drugs. Nat Rev C... |
196 | In Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu2O-ZnO Ternary HeterojunctionIn Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu 2 O-ZnO Ternary Heterojunction
4 January 2024
Au @ Cu
College of Textile and Clothing Engineering
Soochow University
215123SuzhouChina
... |
197 | In Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu2O-ZnO Ternary HeterojunctionIn Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu 2 O-ZnO Ternary Heterojunction
4 January 2024EE7D7511EC1D0FE0A365CDD92864B4CD10.3390/polym16010158Received: 20 November 2023 Revised: 22 D... |
198 | In Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu2O-ZnO Ternary HeterojunctionIntroduction
Polyamide 6,6 (PA66) stands as a prominent member of the group of polyamide materials, holding a significant presence in the consumer market as one of the largest families of engineering plastics [1,2]... |
199 | In Situ Polymerization of Antibacterial Modification Polyamide 66 with Au@Cu2O-ZnO Ternary HeterojunctionIn addition to semiconductor coupling, the hybridization of noble metal nanoparticles, such as Ag, Au, and Pt, holds great potential for elevating catalytic performance through the formation of Schottky barriers [17... |
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