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| TASK_DATA = { | |
| "known_signal_easy": { | |
| "reports": [ | |
| { | |
| "report_id": "PV-EASY-001", | |
| "patient_age": 59, | |
| "patient_sex": "female", | |
| "drugs": ["Lisinopril 20mg"], | |
| "suspect_drug": "Lisinopril", | |
| "reaction": "Persistent dry cough", | |
| "onset_days": 11, | |
| "severity": "mild", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 1264, | |
| } | |
| ], | |
| "ground_truth": { | |
| "classification": "known_side_effect", | |
| "suspect_drug": "Lisinopril", | |
| "severity_assessment": "mild", | |
| "recommended_action": "log_and_monitor", | |
| }, | |
| "drug_interaction_db": { | |
| "Lisinopril": { | |
| "known_reactions": ["dry cough", "hyperkalemia", "angioedema"], | |
| "class_note": "ACE inhibitors frequently cause persistent non-productive cough.", | |
| } | |
| }, | |
| }, | |
| "cluster_signal_medium": { | |
| "reports": [ | |
| { | |
| "report_id": "PV-MED-001", | |
| "patient_age": 44, | |
| "patient_sex": "female", | |
| "drugs": ["Cardiovexa"], | |
| "suspect_drug": "Cardiovexa", | |
| "reaction": "symptomatic bradycardia with dizziness", | |
| "onset_days": 9, | |
| "severity": "moderate", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 5, | |
| }, | |
| { | |
| "report_id": "PV-MED-002", | |
| "patient_age": 69, | |
| "patient_sex": "male", | |
| "drugs": ["Cardiovexa"], | |
| "suspect_drug": "Cardiovexa", | |
| "reaction": "heart rate 32 with near-syncope", | |
| "onset_days": 13, | |
| "severity": "severe", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 5, | |
| }, | |
| { | |
| "report_id": "PV-MED-003", | |
| "patient_age": 57, | |
| "patient_sex": "female", | |
| "drugs": ["Cardiovexa"], | |
| "suspect_drug": "Cardiovexa", | |
| "reaction": "fatigue and sinus bradycardia", | |
| "onset_days": 7, | |
| "severity": "moderate", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 5, | |
| }, | |
| { | |
| "report_id": "PV-MED-004", | |
| "patient_age": 63, | |
| "patient_sex": "male", | |
| "drugs": ["Cardiovexa"], | |
| "suspect_drug": "Cardiovexa", | |
| "reaction": "bradyarrhythmia requiring ER evaluation", | |
| "onset_days": 11, | |
| "severity": "severe", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 5, | |
| }, | |
| ], | |
| "ground_truth": { | |
| "classification": "new_signal", | |
| "suspect_drug": "Cardiovexa", | |
| "severity_assessment": "severe", | |
| "recommended_action": "escalate", | |
| }, | |
| "drug_interaction_db": { | |
| "Cardiovexa": { | |
| "known_reactions": ["headache", "fatigue"], | |
| "approval_date": "5 months ago", | |
| "label_note": "No labeled conduction or rhythm adverse effects.", | |
| } | |
| }, | |
| }, | |
| "confounded_hard": { | |
| "reports": [ | |
| { | |
| "report_id": "PV-HARD-001", | |
| "patient_age": 63, | |
| "patient_sex": "male", | |
| "drugs": [ | |
| "Tacrolimus", | |
| "Prednisone", | |
| "Amlodipine", | |
| "Magnesium oxide", | |
| "Voriconazole", | |
| "Trimethoprim-sulfamethoxazole", | |
| ], | |
| "suspect_drug": "Trimethoprim-sulfamethoxazole", | |
| "reaction": "Acute kidney injury with tacrolimus trough 4x baseline", | |
| "onset_days": 6, | |
| "severity": "critical", | |
| "outcome": "not_recovered", | |
| "similar_reports_last_30d": 1, | |
| } | |
| ], | |
| "ground_truth": { | |
| "classification": "new_signal", | |
| "suspect_drug": "Tacrolimus+Voriconazole", | |
| "severity_assessment": "critical", | |
| "recommended_action": "escalate", | |
| }, | |
| "drug_interaction_db": { | |
| "Voriconazole": { | |
| "strong_metabolic_inhibitor": True, | |
| "interacts_with": ["Tacrolimus", "Cyclosporine"], | |
| "interaction_note": "Markedly increases tacrolimus exposure; dose reduction and level monitoring required.", | |
| }, | |
| "Tacrolimus": { | |
| "narrow_therapeutic_index": True, | |
| "known_reactions": ["nephrotoxicity", "tremor"], | |
| "requires_level_monitoring": True, | |
| }, | |
| }, | |
| }, | |
| } | |