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f2beac3 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 | TASK_DATA = {
"known_signal_easy": {
"reports": [
{
"report_id": "PV-EASY-001",
"patient_age": 59,
"patient_sex": "female",
"drugs": ["Lisinopril 20mg"],
"suspect_drug": "Lisinopril",
"reaction": "Persistent dry cough",
"onset_days": 11,
"severity": "mild",
"outcome": "not_recovered",
"similar_reports_last_30d": 1264,
}
],
"ground_truth": {
"classification": "known_side_effect",
"suspect_drug": "Lisinopril",
"severity_assessment": "mild",
"recommended_action": "log_and_monitor",
},
"drug_interaction_db": {
"Lisinopril": {
"known_reactions": ["dry cough", "hyperkalemia", "angioedema"],
"class_note": "ACE inhibitors frequently cause persistent non-productive cough.",
}
},
},
"cluster_signal_medium": {
"reports": [
{
"report_id": "PV-MED-001",
"patient_age": 44,
"patient_sex": "female",
"drugs": ["Cardiovexa"],
"suspect_drug": "Cardiovexa",
"reaction": "symptomatic bradycardia with dizziness",
"onset_days": 9,
"severity": "moderate",
"outcome": "not_recovered",
"similar_reports_last_30d": 5,
},
{
"report_id": "PV-MED-002",
"patient_age": 69,
"patient_sex": "male",
"drugs": ["Cardiovexa"],
"suspect_drug": "Cardiovexa",
"reaction": "heart rate 32 with near-syncope",
"onset_days": 13,
"severity": "severe",
"outcome": "not_recovered",
"similar_reports_last_30d": 5,
},
{
"report_id": "PV-MED-003",
"patient_age": 57,
"patient_sex": "female",
"drugs": ["Cardiovexa"],
"suspect_drug": "Cardiovexa",
"reaction": "fatigue and sinus bradycardia",
"onset_days": 7,
"severity": "moderate",
"outcome": "not_recovered",
"similar_reports_last_30d": 5,
},
{
"report_id": "PV-MED-004",
"patient_age": 63,
"patient_sex": "male",
"drugs": ["Cardiovexa"],
"suspect_drug": "Cardiovexa",
"reaction": "bradyarrhythmia requiring ER evaluation",
"onset_days": 11,
"severity": "severe",
"outcome": "not_recovered",
"similar_reports_last_30d": 5,
},
],
"ground_truth": {
"classification": "new_signal",
"suspect_drug": "Cardiovexa",
"severity_assessment": "severe",
"recommended_action": "escalate",
},
"drug_interaction_db": {
"Cardiovexa": {
"known_reactions": ["headache", "fatigue"],
"approval_date": "5 months ago",
"label_note": "No labeled conduction or rhythm adverse effects.",
}
},
},
"confounded_hard": {
"reports": [
{
"report_id": "PV-HARD-001",
"patient_age": 63,
"patient_sex": "male",
"drugs": [
"Tacrolimus",
"Prednisone",
"Amlodipine",
"Magnesium oxide",
"Voriconazole",
"Trimethoprim-sulfamethoxazole",
],
"suspect_drug": "Trimethoprim-sulfamethoxazole",
"reaction": "Acute kidney injury with tacrolimus trough 4x baseline",
"onset_days": 6,
"severity": "critical",
"outcome": "not_recovered",
"similar_reports_last_30d": 1,
}
],
"ground_truth": {
"classification": "new_signal",
"suspect_drug": "Tacrolimus+Voriconazole",
"severity_assessment": "critical",
"recommended_action": "escalate",
},
"drug_interaction_db": {
"Voriconazole": {
"strong_metabolic_inhibitor": True,
"interacts_with": ["Tacrolimus", "Cyclosporine"],
"interaction_note": "Markedly increases tacrolimus exposure; dose reduction and level monitoring required.",
},
"Tacrolimus": {
"narrow_therapeutic_index": True,
"known_reactions": ["nephrotoxicity", "tremor"],
"requires_level_monitoring": True,
},
},
},
}
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