pmcid stringclasses 397
values | title stringclasses 397
values | url stringclasses 397
values | chunk_index int64 0 223 | text stringlengths 2 2.2k | embedding listlengths 512 512 |
|---|---|---|---|---|---|
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 0 | After a 16-year hiatus, Russia has resumed its program of biomedical research in space, with the successful 30-day flight of the Bion-M 1 biosatellite (April 19–May 19, 2013). The principal species for biomedical research in this project was the mouse. This paper presents an overview of the scientific goals, the experi... | [
0.04424288,
-0.008465468,
-0.028918533,
-0.019773355,
-0.023728028,
-0.027929865,
0.036827877,
0.0291657,
-0.0037229522,
-0.0021936067,
-0.012976265,
-0.10381012,
-0.0605559,
-0.022862943,
0.0045416923,
-0.007229633,
0.05585973,
-0.00005648151,
0.034603372,
-0.02595253,
0.080... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 1 | “space” paste food are described. The training program for mice designated for in vivo studies was broader and included behavioral/functional test battery and continuous behavioral measurements in the home-cage. The results of the preliminary tests were used for the selection of homogenous groups. After the flight, mic... | [
0.044898722,
0.050059494,
-0.029416403,
0.03973795,
-0.048253223,
-0.0634775,
0.051865764,
-0.016191924,
0.0056768497,
-0.010192526,
-0.0017498245,
-0.051607724,
-0.07121866,
-0.0058381236,
0.055736344,
-0.00077411585,
0.024255631,
-0.015224279,
0.03186777,
0.015869375,
0.061... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 2 | After a 16-year hiatus, Russia resumed in 2013 its program of biomedical research in space, with the successful 30-day flight of the Bion-M 1 biosatellite (April 19–May 19, 2013), a specially designed automated spacecraft dedicated to life-science experiments. “M” in the mission's name stands for “modernized”; the epit... | [
0.05248564,
0.00027395185,
0.009784499,
-0.007352514,
0.019568998,
-0.07284645,
0.026921513,
0.006277916,
-0.0034500258,
-0.006136521,
-0.0050619235,
-0.038911767,
-0.049544636,
-0.042531468,
0.02601659,
-0.02443297,
-0.0052033174,
0.00797465,
0.018098496,
-0.007691861,
0.117... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 3 | monkeys were launched on 11 satellites and exposed in microgravity for 5.0–22.5 days between 1973 and 1997. Animal experiments on the Bion missions have contributed comprehensive data on adaptive responses of sensorimotor, cardiovascular, muscle, bone and other systems to spaceflight conditions and the mechanisms under... | [
0.031472962,
0.010904018,
0.055263545,
-0.022303674,
0.00706283,
-0.09962307,
-0.0068459883,
-0.032464236,
-0.0017966848,
0.030853415,
-0.027260045,
0.017099483,
0.029242594,
-0.04237698,
0.02118849,
-0.0030512663,
0.058980826,
0.02973823,
-0.037172787,
-0.022179764,
0.003035... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 4 | more consistent results. Despite the advantages of the mouse as a model organism for space research, their use was rather limited (apart from a number of experiments with mice during early space exploration in the 1950's and 1960's, which were aimed primarily at testing if living organisms can survive the launch or a b... | [
0.018503632,
-0.030727243,
0.058314472,
0.020073636,
0.0046539437,
-0.08074312,
-0.060557336,
-0.054501604,
-0.02298936,
0.011718966,
0.0076818108,
-0.006924844,
0.028708665,
-0.060108762,
0.044408713,
-0.02781152,
0.01917649,
0.011775038,
0.02298936,
-0.017942915,
0.07715453... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 5 | mice were their wild-type counterparts. The MDS habitats required periodic replenishment and servicing by by astronauts. Sadly, half of the mice died during the course of this mission due to various estimated reasons. In the present paper we aim to present a brief overview of the Bion-M 1 mission scientific goals and e... | [
-0.018665947,
-0.031617828,
0.04139523,
-0.020189699,
-0.024506992,
-0.05155357,
0.00033530453,
0.026919598,
-0.03479231,
0.08533005,
-0.03504627,
-0.02196741,
-0.042157106,
-0.037077934,
-0.0046982314,
0.014221674,
0.06958462,
0.009142505,
0.028316371,
-0.10513881,
0.0160628... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 6 | fitness, as well as continuous registration of cardiovascular parameters were performed. The set of in vivo measurements was designed to provide data on the effects of microgravity on the physiological systems of interest, and to follow the time course of re-adaptation to Earth's gravity after the flight. To reduce the... | [
-0.049114484,
-0.023933962,
0.022687402,
0.028047612,
0.017950473,
-0.033657134,
0.038892686,
0.028546236,
0.035900947,
0.0015036636,
-0.02530518,
-0.014896398,
-0.07778537,
-0.037646126,
-0.039391313,
0.04961311,
0.0067625907,
-0.0014335446,
0.0040824856,
-0.028920205,
0.010... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 7 | supporting tissues, including bone and connective tissues, cardiovascular, respiratory, digestive, neuroendocrine and immune systems. The following organs and tissues were harvested: brain structures, vestibular organs, retina and crystalline lens, spinal cord, muscles of hind limbs and back, vertebral column, fore and... | [
0.0030782176,
0.028730031,
-0.03707101,
0.004964867,
-0.042102072,
-0.074671604,
-0.00055027276,
-0.02091864,
-0.009466347,
0.028862426,
-0.038924556,
-0.09744379,
-0.057724852,
-0.02912722,
-0.013835429,
0.013173448,
0.10591716,
0.054547343,
0.04024852,
0.006222633,
0.036806... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 8 | The scientific program of the Bion-M 1 project was aimed at obtaining data on mechanisms of adaptation of muscle, bone, cardiovascular, sensorimotor and nervous systems to prolonged exposure in microgravity and during post-flight recovery. To this aim, functional measurements in vivo were combined with complementary mo... | [
-0.000087384746,
-0.033187,
0.030359957,
0.0032726068,
-0.005899911,
-0.052361708,
0.026672512,
0.060474087,
-0.01843722,
0.054328345,
-0.018560136,
-0.027532917,
-0.059982426,
-0.023353813,
-0.015425809,
0.012906055,
0.0572783,
-0.0013674272,
0.0025658465,
-0.055065833,
0.03... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 9 | an automated data collection system (TSE PhenoMaster) and implantable telemetry, while reducing the number of tests [11] . The program had to be performed with a limited number of animals; thus the use of a repeated measures design. Mice were tested before and after the flight (or its simulation on-ground) [12] . The i... | [
-0.034242973,
0.040448077,
0.035621885,
-0.00580292,
-0.004912373,
-0.05814411,
0.027808053,
0.03148515,
0.010226929,
0.005544374,
-0.042746264,
-0.03148515,
-0.07997688,
-0.05791429,
-0.03493243,
0.075840145,
0.03148515,
0.022866951,
0.005716738,
-0.04642336,
0.05699502,
-... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 10 | electron microscopy, histochemistry and immunohistochemistry), biochemical and a variety of molecular-biology techniques (enzyme-linked immune assays, high-pressure liquid chromatography, western-blot, real-time PCR, whole-genome gene expression). Functional properties of skeletal muscle, cardiac muscle and resistive a... | [
0.004495293,
0.024599245,
-0.053693783,
0.0052132914,
0.0073985034,
-0.072424166,
0.046701103,
-0.075421035,
0.018230913,
0.036711562,
-0.02847019,
-0.069427304,
-0.019854212,
-0.0066180704,
-0.004120685,
-0.0078979805,
0.033215225,
0.041206855,
0.019604472,
-0.0001970593,
0.... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 11 | The study was approved by IACUC of MSU Institute of Mitoengineering (Protocol № 35, 1 November, 2012) and of Biomedical Ethics Commission of IBMP (protocol № 319, 4 April, 2013) and conducted in compliance with the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific P... | [
-0.0038471394,
0.03906326,
-0.010653616,
-0.031487357,
0.0023082835,
-0.06865664,
-0.008937201,
-0.08475544,
-0.047112662,
0.018111149,
0.022254223,
-0.056345794,
-0.02118886,
-0.0023082835,
0.055872303,
-0.029356634,
0.03503856,
0.010180122,
0.017637653,
0.035748806,
-0.0008... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 12 | age, and obesity, which C57/BL6 mice are prone to exhibit, is not yet considered a factor. Space environment affects microorganisms by increasing their virulence; major shifts in immune status in space are well documented [5] , [8] . It is reasonable to think that even pseudo pathogenic species may increase morbidity d... | [
-0.005768437,
0.019845814,
0.056907274,
-0.0049614534,
-0.014944137,
-0.053081576,
-0.028094979,
-0.034670398,
0.030366488,
0.0021519559,
-0.047343027,
-0.06360225,
-0.006425979,
-0.028214531,
0.017335199,
-0.044234645,
0.043756437,
-0.023073748,
0.040408947,
0.029649168,
0.0... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 13 | on May 19, 2013 in the vicinity of Orenburg, successfully fulfilling the plan for an unmanned, 30-day-long orbital spaceflight. Housing and climate parameters were replicated in the subsequent ground control (GC) experiment (July 26 to August 26, 2013). A total of 4 experimental groups were used for the flight and grou... | [
-0.038729742,
-0.009897602,
0.05443681,
-0.021408942,
-0.021086194,
-0.023668177,
-0.03162929,
-0.035932597,
-0.008014906,
-0.023668177,
-0.052285153,
-0.02990797,
-0.024744004,
0.0040881396,
0.07358651,
-0.02420609,
0.027541151,
-0.011242384,
0.050994165,
-0.028832145,
0.048... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 14 | in vitro measurements (n = 35). Each in vivo study subgroup, in its turn, consisted of 5 mice implanted with telemetry probes to monitor blood pressure and 5 intact animals. Mice were handled and trained before the flight and ground control experiments. Basically, training consisted of shaping the groups of three mice ... | [
-0.013637178,
0.021339657,
0.020708308,
-0.012816421,
-0.026390463,
-0.00021209441,
0.05505379,
-0.0047035636,
-0.027905706,
-0.021213388,
-0.032830242,
-0.11970411,
-0.0732367,
-0.031188728,
0.0045772935,
-0.020708308,
0.022223549,
-0.012816421,
0.04469964,
0.0048614014,
0.0... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 15 | habitats were designed to house up to three mice per group [17] . Stable cohorts of three mice were maintained throughout the training program and consequent experiments, with the exception of brief periods of post-surgery recovery (5–6 days) and behavioral tests (7 days), when they were housed individually. Individual... | [
0.047219183,
-0.010442705,
0.017820701,
0.0057605132,
-0.0237231,
-0.049716353,
0.0025964875,
-0.08808194,
-0.015664056,
-0.047219183,
-0.014642488,
-0.04540306,
0.008569828,
0.060840104,
0.050170384,
0.0018161226,
0.022133993,
-0.027809376,
0.055391736,
-0.032236174,
0.06492... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 16 | l ( Figure 2 ). A stainless steel feeder (9 ml) was mounted at one end (the “top”) of the cylinder. The feeder had a flap, used in the refill procedure. The food distribution system (except for the feeders) was common to all five habitats in the block. Paste “space” food was pumped from the container and distributed be... | [
-0.019218648,
-0.03098517,
-0.015002312,
-0.009609324,
0.017551724,
0.013629552,
0.065108076,
-0.110605285,
0.01005057,
-0.03490734,
0.036476213,
-0.021375844,
0.0022552495,
0.03686843,
0.072560206,
0.00030029137,
-0.014904259,
0.039810058,
0.0005331704,
-0.029808518,
0.04686... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 17 | window. In order to minimize impact of variability arising from possible differences in mice housing conditions, experimental subgroups were formed from mice that were housed in different habitats. Air composition and climate parameters in the satellite were maintained by the centralized life support system and remaine... | [
-0.0274743,
0.028593162,
0.024739303,
0.038289975,
-0.038538612,
0.0011654822,
0.066634506,
-0.06713177,
-0.005625394,
-0.045003153,
-0.046743605,
-0.025733847,
-0.06713177,
-0.00043899828,
0.0576836,
-0.06812632,
0.026728392,
0.006433462,
0.0810554,
0.0377927,
0.032322705,
... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 18 | ten days in ten randomly chosen cages per group. Data for the cage was averaged across the days and expressed as g per 10 g bodyweight. A separate preliminary experiment in metabolic chambers was conducted to quantify urination in mice fed standard chow and paste food. Four groups of mice, of 3 mice each, were housed i... | [
0.055132672,
0.03881538,
0.04647956,
-0.01075458,
-0.022374468,
-0.03065673,
0.034365207,
-0.019654922,
-0.052413125,
-0.0016456362,
-0.037331987,
-0.07515844,
-0.08603664,
-0.0048519224,
-0.021261927,
0.01903684,
-0.0013288704,
0.022127239,
0.01940769,
-0.021880006,
0.073675... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 19 | tiletamine/zolazepam (15 mg/kg each) combined with xylazine (3 mg/kg). Depth of anesthesia was assessed regularly by hind leg pinch and observation of respiration rate, and maintained by additional dose(s) of the mixture (about 20% of the initial dose) as needed. A midline incision was made on the ventral neck. The car... | [
0.06768041,
0.08653425,
-0.03311506,
0.012327504,
0.03480707,
-0.05801178,
0.028401602,
-0.011118925,
0.04665114,
0.021875277,
-0.014623803,
-0.084600516,
-0.026588734,
0.052210607,
-0.009366486,
0.043508835,
-0.015711525,
0.048584867,
0.043267123,
-0.03843281,
0.0050458163,
... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 20 | design; the latter consideration was particularly important in light of relatively small number of animals. On the morning of day 0 mice a battery of behavioral and functional tests was administered. First, animals were examined for visible abnormalities in exterior and simple reflexes [19] . The Open field test was pe... | [
0.033459593,
-0.0070380517,
-0.0047593387,
-0.048227962,
0.01263388,
-0.01869122,
-0.020421889,
0.040382266,
-0.02307558,
0.018460464,
-0.0022210246,
-0.06922674,
-0.0016585573,
0.026998429,
-0.011076279,
-0.02861372,
0.035536394,
0.029305987,
-0.02099878,
0.1273772,
0.055612... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 21 | equipped with an infrared grid to register animal activity, scales for the water bottle and feeder, a running wheel with unrestricted access and rotation counter, an “operant wall” for positively reinforced operant conditioning [23] . There were 16 such cages, housing mice individually. Measures were read once per minu... | [
0.030789826,
0.017358875,
0.025974957,
-0.028635805,
-0.010389983,
0.034464333,
0.046121385,
0.017232167,
-0.0249613,
-0.016471924,
0.030916534,
-0.09883154,
-0.0249613,
-0.022680573,
-0.0051949914,
-0.06740818,
0.013240893,
0.01051669,
-0.05600454,
0.03623823,
0.007982547,
... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 22 | mice), probabilities of running wheel use, combined with performance in conditioning task were used as criteria for inclusion into experimental groups. Selected mice were randomly assigned to either flight or ground control or vivarium groups. The groups of mice designated for flight were transported to Cosmodrome Baik... | [
0.02913892,
0.008087286,
0.08050244,
-0.010556686,
-0.0765514,
-0.040745102,
-0.024817472,
-0.046424724,
-0.018150091,
-0.019878672,
-0.043708384,
-0.103220925,
-0.060253363,
0.012470471,
0.046671662,
0.0033799915,
0.07506976,
0.009568925,
0.008642901,
0.03753488,
0.047165543... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 23 | (metabolic chambers data) was performed using GraphPad Prism software (version 6.00 for MacOS, GraphPad Software, USA). | [
0.04318912,
0.062177442,
-0.021315321,
-0.00029378379,
-0.053241763,
0.010936901,
-0.06850688,
0.0062363604,
0.02401464,
0.021780722,
0.014985881,
0.016195921,
-0.02587624,
0.09419696,
-0.016009761,
-0.02084992,
-0.07595328,
-0.039652083,
-0.028482482,
-0.018616,
0.0096803205... |
4136787 | Mice in Bion-M 1 Space Mission: Training and Selection | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136787/ | 24 | The study was approved by IACUC of MSU Institute of Mitoengineering (Protocol № 35, 1 November, 2012) and of Biomedical Ethics Commission of IBMP (protocol № 319, 4 April, 2013) and conducted in compliance with the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific P... | [
0.049274422,
0.060669135,
-0.014474361,
-0.034030147,
-0.06159303,
-0.038495645,
-0.040959362,
-0.06036117,
-0.01016285,
0.018323926,
0.0077376245,
-0.09300547,
-0.028178811,
-0.009739398,
0.006659746,
-0.05204611,
-0.06498064,
0.014474361,
-0.02340535,
0.013396484,
0.0170920... |
End of preview. Expand in Data Studio
No dataset card yet
- Downloads last month
- 14