accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
A0A1W2PPG7 | GBG14_HUMAN | Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 | Homo | <M><S><S><K><V><A><I><N><S><D><I><G><Q><A><L><W><A><V><E><Q><L><Q><M><E><A><G><I><D><Q><V><K><M><A><A><D><L><L><K><F><C><T><E><Q><A><K><N><D><P><F><L><V><G><I><P><A><A><T><N><S><F><K><E><K><K><P><Y><A><I><L> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP> | A0A1W2PPG7 |
Q9NX24 | NHP2_HUMAN | snoRNP protein NHP2 | Homo | <M><T><K><I><K><A><D><P><D><G><P><E><A><Q><A><E><A><C><S><G><E><R><T><Y><Q><E><L><L><V><N><Q><N><P><I><A><Q><P><L><A><S><R><R><L><T><R><K><L><Y><K><C><I><K><K><A><V><K><Q><K><Q><I><R><R><G><V><K><E><V><Q><K><F><V><N><K><G><E><K><G><I><M><V><L><A><G><D><T><L><P><I><E><V><Y><C><H><L><P><V><M><C><E><D><R><N><L><P><Y><V><Y... | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contai... | Q9NX24 |
O94811 | TPPP_HUMAN | p25-alpha | Homo | <M><A><D><K><A><K><P><A><K><A><A><N><R><T><P><P><K><S><P><G><D><P><S><K><D><R><A><A><K><R><L><S><L><E><S><E><G><A><G><E><G><A><A><A><S><P><E><L><S><A><L><E><E><A><F><R><R><F><A><V><H><G><D><A><R><A><T><G><R><E><M><H><G><K><N><W><S><K><L><C><K><D><C><Q><V><I><D><G><R><N><V><T><V><T><D><V><D><I><V><F><S><K><I><K><G><K><S... | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath . Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an importan... | O94811 |
Q86W10 | CP4Z1_HUMAN | Laurate 7-monooxygenase | Homo | <M><E><P><S><W><L><Q><E><L><M><A><H><P><F><L><L><L><I><L><L><C><M><S><L><L><L><F><Q><V><I><R><L><Y><Q><R><R><R><W><M><I><R><A><L><H><L><F><P><A><P><P><A><H><W><F><Y><G><H><K><E><F><Y><P><V><K><E><F><E><V><Y><H><K><L><M><E><K><Y><P><C><A><V><P><L><W><V><G><P><F><T><M><F><F><S><V><H><D><P><D><Y><A><K><I><L><L><K><R><Q><D... | A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids ... | Q86W10 |
P48145 | NPBW1_HUMAN | G-protein coupled receptor 7 | Homo | <M><D><N><A><S><F><S><E><P><W><P><A><N><A><S><G><P><D><P><A><L><S><C><S><N><A><S><T><L><A><P><L><P><A><P><L><A><V><A><V><P><V><V><Y><A><V><I><C><A><V><G><L><A><G><N><S><A><V><L><Y><V><L><L><R><A><P><R><M><K><T><V><T><N><L><F><I><L><N><L><A><I><A><D><E><L><F><T><L><V><L><P><I><N><I><A><D><F><L><L><R><Q><W><P><F><G><E><L... | Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.<BOP> | P48145 |
Q8NGT1 | OR2K2_HUMAN | Olfactory receptor OR9-17 | Homo | <M><Q><G><E><N><F><T><I><W><S><I><F><F><L><E><G><F><S><Q><Y><P><G><L><E><V><V><L><F><V><F><S><L><V><M><Y><L><T><T><L><L><G><N><S><T><L><I><L><I><T><I><L><D><S><R><L><K><T><P><M><Y><L><F><L><G><N><L><S><F><M><D><I><C><Y><T><S><A><S><V><P><T><L><L><V><N><L><L><S><S><Q><K><T><I><I><F><S><G><C><A><V><Q><M><Y><L><S><L><A><M... | Odorant receptor.<BOP> | Q8NGT1 |
P60608 | EFC2_HUMAN | Truncated transmembrane protein | Homo | <M><N><S><P><C><D><R><L><Q><Q><F><I><Q><V><L><L><E><E><S><W><S><F><P><S><F><A><N><T><L><H><W><P><E><N><L><L><S><Y><I><D><E><L><V><W><Q><G><S><L><Q><N><F><H><Q><H><E><V><R><F><D><K><P><P><L><R><L><P><L><T><G><F><S><S><L><T><E><N><W><S><S><R><Q><A><V><S><S><R><L><V><A><T><A><A><S><P><P><A><G><C><Q><A><P><I><A><F><L><G><L... | Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.<BOP> | P60608 |
P06858 | LIPL_HUMAN | Phospholipase A1 | Homo | <M><E><S><K><A><L><L><V><L><T><L><A><V><W><L><Q><S><L><T><A><S><R><G><G><V><A><A><A><D><Q><R><R><D><F><I><D><I><E><S><K><F><A><L><R><T><P><E><D><T><A><E><D><T><C><H><L><I><P><G><V><A><E><S><V><A><T><C><H><F><N><H><S><S><K><T><F><M><V><I><H><G><W><T><V><T><G><M><Y><E><S><W><V><P><K><L><V><A><A><L><Y><K><R><E><P><D><S><N... | Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage . Although it has both phospholipase and triglyceride lipas... | P06858 |
O76002 | OR2J2_HUMAN | Olfactory receptor OR6-19 | Homo | <M><M><I><K><K><N><A><S><S><E><D><F><F><I><L><L><G><F><S><N><W><P><Q><L><E><V><V><L><F><V><V><I><L><I><F><Y><L><M><T><L><T><G><N><L><F><I><I><I><L><S><Y><V><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><L><D><L><C><H><T><T><S><S><I><P><Q><L><L><V><N><L><R><G><P><E><K><T><I><S><Y><A><G><C><M><V><Q><L><Y><F><V><L><A... | Odorant receptor.<BOP> | O76002 |
O95988 | TCL1B_HUMAN | TCL1/MTCP1-like protein 1 | Homo | <M><A><S><E><A><S><V><R><L><G><V><P><P><G><R><L><W><I><Q><R><P><G><I><Y><E><D><E><E><G><R><T><W><V><T><V><V><V><R><F><N><P><S><R><R><E><W><A><R><A><S><Q><G><S><R><Y><E><P><S><I><T><V><H><L><W><Q><M><A><V><H><T><R><E><L><L><S><S><G><Q><M><P><F><S><Q><L><P><A><V><W><Q><L><Y><P><G><R><K><Y><R><A><A><D><S><S><F><W><E><I><A... | Enhances the phosphorylation and activation of AKT1 and AKT2.<BOP> | O95988 |
O75807 | PR15A_HUMAN | Myeloid differentiation primary response protein MyD116 homolog | Homo | <M><A><P><G><Q><A><P><H><Q><A><T><P><W><R><D><A><H><P><F><F><L><L><S><P><V><M><G><L><L><S><R><A><W><S><R><L><R><G><L><G><P><L><E><P><W><L><V><E><A><V><K><G><A><A><L><V><E><A><G><L><E><G><E><A><R><T><P><L><A><I><P><H><T><P><W><G><R><R><P><E><E><E><A><E><D><S><G><G><P><G><E><D><R><E><T><L><G><L><K><T><S><S><S><L><P><E><A... | (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR.<BOP> | O75807 |
P05187 | PPB1_HUMAN | Placental alkaline phosphatase 1 | Homo | <M><L><G><P><C><M><L><L><L><L><L><L><L><G><L><R><L><Q><L><S><L><G><I><I><P><V><E><E><E><N><P><D><F><W><N><R><E><A><A><E><A><L><G><A><A><K><K><L><Q><P><A><Q><T><A><A><K><N><L><I><I><F><L><G><D><G><M><G><V><S><T><V><T><A><A><R><I><L><K><G><Q><K><K><D><K><L><G><P><E><I><P><L><A><M><D><R><F><P><Y><V><A><L><S><K><T><Y><N><V... | Alkaline phosphatase that can hydrolyze various phosphate compounds.<BOP> | P05187 |
Q8IZT8 | HS3S5_HUMAN | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5 | Homo | <M><L><F><K><Q><Q><A><W><L><R><Q><K><L><L><V><L><G><S><L><A><V><G><S><L><L><Y><L><V><A><R><V><G><S><L><D><R><L><Q><P><I><C><P><I><E><G><R><L><G><G><A><R><T><Q><A><E><F><P><L><R><A><L><Q><F><K><R><G><L><L><H><E><F><R><K><G><N><A><S><K><E><Q><V><R><L><H><D><L><V><Q><Q><L><P><K><A><I><I><I><G><V><R><K><G><G><T><R><A><L><L... | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant hepar... | Q8IZT8 |
P49019 | HCAR3_HUMAN | Nicotinic acid receptor 2 | Homo | <M><N><R><H><H><L><Q><D><H><F><L><E><I><D><K><K><N><C><C><V><F><R><D><D><F><I><A><K><V><L><P><P><V><L><G><L><E><F><I><F><G><L><L><G><N><G><L><A><L><W><I><F><C><F><H><L><K><S><W><K><S><S><R><I><F><L><F><N><L><A><V><A><D><F><L><L><I><I><C><L><P><F><V><M><D><Y><Y><V><R><R><S><D><W><K><F><G><D><I><P><C><R><L><V><L><F><M><F... | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic aci... | P49019 |
Q9UJ78 | ZMYM5_HUMAN | Zinc finger protein 237 | Homo | <M><E><K><C><S><V><G><G><L><E><L><T><E><Q><T><P><A><L><L><G><N><M><A><M><A><T><S><L><M><D><I><G><D><S><F><G><H><P><A><C><P><L><V><S><R><S><R><N><S><P><V><E><D><D><D><D><D><D><D><V><V><F><I><E><S><I><Q><P><P><S><I><S><A><P><A><I><A><D><Q><R><N><F><I><F><A><S><S><K><N><E><K><P><Q><G><N><Y><S><V><I><P><P><S><S><R><D><L><A... | Functions as a transcriptional regulator.<BOP> | Q9UJ78 |
O15205 | UBD_HUMAN | Ubiquitin-like protein FAT10 | Homo | <M><A><P><N><A><S><C><L><C><V><H><V><R><S><E><E><W><D><L><M><T><F><D><A><N><P><Y><D><S><V><K><K><I><K><E><H><V><R><S><K><T><K><V><P><V><Q><D><Q><V><L><L><L><G><S><K><I><L><K><P><R><R><S><L><S><S><Y><G><I><D><K><E><K><T><I><H><L><T><L><K><V><V><K><P><S><D><E><E><L><P><L><F><L><V><E><S><G><D><E><A><K><R><H><L><L><Q><V><R... | Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 ... | O15205 |
Q8WVZ9 | KBTB7_HUMAN | Kelch repeat and BTB domain-containing protein 7 | Homo | <M><Q><S><R><E><D><V><P><R><S><R><R><L><A><S><P><R><G><G><R><R><P><K><R><I><S><K><P><S><V><S><A><F><F><T><G><P><E><E><L><K><D><T><A><H><S><A><A><L><L><A><Q><L><K><S><F><Y><D><A><R><L><L><C><D><V><T><I><E><V><V><T><P><G><S><G><P><G><T><G><R><L><F><S><C><N><R><N><V><L><A><A><A><C><P><Y><F><K><S><M><F><T><G><G><M><Y><E><S... | As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation . By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes incl... | Q8WVZ9 |
Q14213 | IL27B_HUMAN | Epstein-Barr virus-induced gene 3 protein | Homo | <M><T><P><Q><L><L><L><A><L><V><L><W><A><S><C><P><P><C><S><G><R><K><G><P><P><A><A><L><T><L><P><R><V><Q><C><R><A><S><R><Y><P><I><A><V><D><C><S><W><T><L><P><P><A><P><N><S><T><S><P><V><S><F><I><A><T><Y><R><L><G><M><A><A><R><G><H><S><W><P><C><L><Q><Q><T><P><T><S><T><S><C><T><I><T><D><V><Q><L><F><S><M><A><P><Y><V><L><N><V><T... | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that... | Q14213 |
Q8N7E2 | CBLL2_HUMAN | c-Cbl-like protein 2 | Homo | <M><N><K><M><P><A><G><E><Q><E><C><E><Y><N><K><E><G><K><Y><Y><S><K><G><V><K><L><V><R><K><K><K><K><I><P><G><Y><R><W><G><D><I><K><I><N><I><I><G><E><K><D><D><L><P><I><H><F><C><D><K><C><D><L><P><I><K><I><Y><G><R><I><I><P><C><K><H><A><F><C><Y><H><C><A><N><L><Y><D><K><V><G><Y><K><V><C><P><R><C><R><Y><P><V><L><R><I><E><A><H><K... | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . May operate on tyrosine-phosphorylated SRC substrates .<BOP> | Q8N7E2 |
Q8NEA4 | FBX36_HUMAN | F-box only protein 36 | Homo | <M><A><S><W><L><P><E><T><L><F><E><T><V><G><Q><G><P><P><P><S><K><D><Y><Y><Q><L><L><V><T><R><S><Q><V><I><F><R><W><W><K><I><S><L><R><S><E><Y><R><S><T><K><P><G><E><A><K><E><T><H><E><D><F><L><E><N><S><H><L><Q><G><Q><T><A><L><I><F><G><A><R><I><L><D><Y><V><I><N><L><C><K><G><K><F><D><F><L><E><R><L><S><D><D><L><L><L><T><I><I><S... | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP> | Q8NEA4 |
O95013 | O4F21_HUMAN | Olfactory receptor 4F21 | Homo | <M><D><G><E><N><H><S><V><V><S><E><F><L><F><L><G><L><T><H><S><W><E><I><Q><L><L><L><L><V><F><S><S><V><L><Y><V><A><S><I><T><G><N><I><F><I><V><F><S><V><T><T><D><P><H><L><H><S><P><M><Y><F><L><L><A><S><L><S><F><I><D><L><G><A><C><S><V><T><S><P><K><M><I><Y><D><L><F><R><K><R><K><V><I><S><F><G><G><C><I><A><Q><I><F><F><I><H><V><I... | Odorant receptor.<BOP> | O95013 |
Q9P109 | GCNT4_HUMAN | Core2-GlcNAc-transferase 3 | Homo | <M><K><I><F><K><C><Y><F><K><H><T><L><Q><Q><K><V><F><I><L><F><L><T><L><W><L><L><S><L><L><K><L><L><N><V><R><R><L><F><P><Q><K><D><I><Y><L><V><E><Y><S><L><S><T><S><P><F><V><R><N><R><Y><T><H><V><K><D><E><V><R><Y><E><V><N><C><S><G><I><Y><E><Q><E><P><L><E><I><G><K><S><L><E><I><R><R><R><D><I><I><D><L><E><D><D><D><V><V><A><M><T... | Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity.<BOP> | Q9P109 |
Q96Q45 | TM237_HUMAN | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein | Homo | <M><R><T><D><S><G><A><R><L><E><E><G><H><L><R><P><P><R><A><L><P><P><V><P><S><Q><D><D><I><P><L><S><R><P><K><K><K><K><P><R><T><K><N><T><P><A><S><A><S><L><E><G><L><A><Q><T><A><G><R><R><P><S><E><G><N><E><P><S><T><K><E><L><K><E><H><P><E><A><P><V><Q><R><R><Q><K><K><T><R><L><P><L><E><L><E><T><S><S><T><Q><K><K><S><S><S><S><S><L... | Component of the transition zone in primary cilia. Required for ciliogenesis.<BOP> | Q96Q45 |
A5D8T8 | CL18A_HUMAN | Mannose receptor-like protein 2 | Homo | <M><L><H><P><E><T><S><P><G><R><G><H><L><L><A><V><L><L><A><L><L><G><T><A><W><A><E><V><W><P><P><Q><L><Q><E><Q><A><P><M><A><G><A><L><N><R><K><E><S><F><L><L><L><S><L><H><N><R><L><R><S><W><V><Q><P><P><A><A><D><M><R><R><L><D><W><S><D><S><L><A><Q><L><A><Q><A><R><A><A><L><C><G><T><P><T><P><S><L><A><S><G><L><W><R><T><L><Q><V><G... | Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans .<BOP> | A5D8T8 |
Q0VDE8 | ADIG_HUMAN | Adipogenin | Homo | <M><K><Y><P><L><M><P><L><V><N><D><L><T><F><S><F><L><V><F><W><F><C><L><P><V><G><L><L><L><L><L><I><I><W><L><R><F><L><L><S><Q><D><S><E><E><N><D><S><S><V><C><L><D><W><E><P><W><S><K><G><P><A><E><F><C><W><K><G><T><L><H><G><Q><E><K><E><R><P><C><W> | Plays a role in stimulating adipocyte differentiation and development.<BOP> | Q0VDE8 |
Q5VVX9 | UBE2U_HUMAN | Ubiquitin-protein ligase U | Homo | <M><H><G><R><A><Y><L><L><L><H><R><D><F><C><D><L><K><E><N><N><Y><K><G><I><T><A><K><P><V><S><E><D><M><M><E><W><E><V><E><I><E><G><L><Q><N><S><V><W><Q><G><L><V><F><Q><L><T><I><H><F><T><S><E><Y><N><Y><A><P><P><V><V><K><F><I><T><I><P><F><H><P><N><V><D><P><H><T><G><Q><P><C><I><D><F><L><D><N><P><E><K><W><N><T><N><Y><T><L><S><S... | Catalyzes the covalent attachment of ubiquitin to other proteins.<BOP> | Q5VVX9 |
Q5T753 | LCE1E_HUMAN | Late envelope protein 5 | Homo | <M><S><C><Q><Q><S><Q><Q><Q><C><Q><P><P><P><K><C><T><P><K><C><P><P><K><C><P><T><P><K><C><P><P><K><C><P><P><K><C><P><P><V><S><S><C><C><S><V><S><S><G><G><C><C><G><S><S><S><G><G><S><C><G><S><S><S><G><G><C><C><S><S><G><G><G><G><C><C><L><S><H><H><R><H><H><R><S><H><R><H><R><P><Q><S><S><D><C><C><S><Q><P><S><G><G><S><S><C><C><G... | Precursors of the cornified envelope of the stratum corneum.<BOP> | Q5T753 |
Q8TCV5 | WFDC5_HUMAN | p53-responsive gene 5 protein | Homo | <M><R><T><Q><S><L><L><L><L><G><A><L><L><A><V><G><S><Q><L><P><A><V><F><G><R><K><K><G><E><K><S><G><G><C><P><P><D><D><G><P><C><L><L><S><V><P><D><Q><C><V><E><D><S><Q><C><P><L><T><R><K><C><C><Y><R><A><C><F><R><Q><C><V><P><R><V><S><V><K><L><G><S><C><P><E><D><Q><L><R><C><L><S><P><M><N><H><L><C><H><K><D><S><D><C><S><G><K><K><R... | Putative acid-stable proteinase inhibitor.<BOP> | Q8TCV5 |
Q9H8T0 | AKTIP_HUMAN | Fused toes protein homolog | Homo | <M><N><P><F><W><S><M><S><T><S><S><V><R><K><R><S><E><G><E><E><K><T><L><T><G><D><V><K><T><S><P><P><R><T><A><P><K><K><Q><L><P><S><I><P><K><N><A><L><P><I><T><K><P><T><S><P><A><P><A><A><Q><S><T><N><G><T><H><A><S><Y><G><P><F><Y><L><E><Y><S><L><L><A><E><F><T><L><V><V><K><Q><K><L><P><G><V><Y><V><Q><P><S><Y><R><S><A><L><M><W><F... | Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B... | Q9H8T0 |
Q16280 | CNGA2_HUMAN | Cyclic nucleotide-gated channel alpha-2 | Homo | <M><T><E><K><T><N><G><V><K><S><S><P><A><N><N><H><N><H><H><A><P><P><A><I><K><A><N><G><K><D><D><H><R><T><S><S><R><P><H><S><A><A><D><D><D><T><S><S><E><L><Q><R><L><A><D><V><D><A><P><Q><Q><G><R><S><G><F><R><R><I><V><R><L><V><G><I><I><R><E><W><A><N><K><N><F><R><E><E><E><P><R><P><D><S><F><L><E><R><F><R><G><P><E><L><Q><T><V><T... | Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.<BOP> | Q16280 |
Q496J9 | SV2C_HUMAN | Synaptic vesicle glycoprotein 2C | Homo | <M><E><D><S><Y><K><D><R><T><S><L><M><K><G><A><K><D><I><A><R><E><V><K><K><Q><T><V><K><K><V><N><Q><A><V><D><R><A><Q><D><E><Y><T><Q><R><S><Y><S><R><F><Q><D><E><E><D><D><D><D><Y><Y><P><A><G><E><T><Y><N><G><E><A><N><D><D><E><G><S><S><E><A><T><E><G><H><D><E><D><D><E><I><Y><E><G><E><Y><Q><G><I><P><S><M><N><Q><A><K><D><S><I><V... | (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.<BOP> | Q496J9 |
Q9BVM2 | DPCD_HUMAN | Protein DPCD | Homo | <M><A><V><T><G><W><L><E><S><L><R><T><A><Q><K><T><A><L><L><Q><D><G><R><R><K><V><H><Y><L><F><P><D><G><K><E><M><A><E><E><Y><D><E><K><T><S><E><L><L><V><R><K><W><R><V><K><S><A><L><G><A><M><G><Q><W><Q><L><E><V><G><D><P><A><P><L><G><A><G><N><L><G><P><E><L><I><K><E><S><N><A><N><P><I><F><M><R><K><D><T><K><M><S><F><Q><W><R><I><R... | May play a role in the formation or function of ciliated cells.<BOP> | Q9BVM2 |
Q8NGJ2 | O52H1_HUMAN | Olfactory receptor OR11-45 | Homo | <M><P><S><A><S><A><M><I><I><F><N><L><S><S><Y><N><P><G><P><F><I><L><V><G><I><P><G><L><E><Q><F><H><V><W><I><G><I><P><F><C><I><I><Y><I><V><A><V><V><G><N><C><I><L><L><Y><L><I><V><V><E><H><S><L><H><E><P><M><F><F><F><L><S><M><L><A><M><T><D><L><I><L><S><T><A><G><V><P><K><A><L><S><I><F><W><L><G><A><R><E><I><T><F><P><G><C><L><T... | Odorant receptor.<BOP> | Q8NGJ2 |
Q9UK85 | DKKL1_HUMAN | Protein soggy-1 | Homo | <M><G><E><A><S><P><P><A><P><A><R><R><H><L><L><V><L><L><L><L><L><S><T><L><V><I><P><S><A><A><A><P><I><H><D><A><D><A><Q><E><S><S><L><G><L><T><G><L><Q><S><L><L><Q><G><F><S><R><L><F><L><K><G><N><L><L><R><G><I><D><S><L><F><S><A><P><M><D><F><R><G><L><P><G><N><Y><H><K><E><E><N><Q><E><H><Q><L><G><N><N><T><L><S><S><H><L><Q><I><D... | Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.<BOP> | Q9UK85 |
Q9Y5K3 | PCY1B_HUMAN | Phosphorylcholine transferase B | Homo | <M><P><V><V><T><T><D><A><E><S><E><T><G><I><P><K><S><L><S><N><E><P><P><S><E><T><M><E><E><I><E><H><T><C><P><Q><P><R><L><T><L><T><A><P><A><P><F><A><D><E><T><N><C><Q><C><Q><A><P><H><E><K><L><T><I><A><Q><A><R><L><G><T><P><A><D><R><P><V><R><V><Y><A><D><G><I><F><D><L><F><H><S><G><H><A><R><A><L><M><Q><A><K><T><L><F><P><N><S><Y... | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.<BOP> | Q9Y5K3 |
Q5T4D3 | TMTC4_HUMAN | Transmembrane and TPR repeat-containing protein 4 | Homo | <M><A><V><L><D><T><D><L><D><H><I><L><P><S><S><V><L><P><P><F><W><A><K><L><V><V><G><S><V><A><I><V><C><F><A><R><S><Y><D><G><D><F><V><F><D><D><S><E><A><I><V><N><N><K><D><L><Q><A><E><T><P><L><G><D><L><W><H><H><D><F><W><G><S><R><L><S><S><N><T><S><H><K><S><Y><R><P><L><T><V><L><T><F><R><I><N><Y><Y><L><S><G><G><F><H><P><V><G><F... | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions.... | Q5T4D3 |
Q8TCE6 | DEN10_HUMAN | Protein FAM45A | Homo | <M><A><A><A><E><V><A><D><T><Q><L><M><L><G><V><G><L><I><E><K><D><T><N><G><E><V><L><W><V><W><C><Y><P><S><T><T><A><T><L><R><N><L><L><L><R><K><C><C><L><T><D><E><N><K><L><L><H><P><F><V><F><G><Q><Y><R><R><T><W><F><Y><I><T><T><I><E><V><P><D><S><S><I><L><K><K><V><T><H><F><S><I><V><L><T><A><K><D><F><N><P><E><K><Y><A><A><F><T><R... | Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into thei... | Q8TCE6 |
Q8N3J3 | HROB_HUMAN | Homologous recombination OB-fold protein | Homo | <M><A><C><S><L><Q><K><L><F><A><V><E><E><E><F><E><D><E><D><F><L><S><A><V><E><D><A><E><N><R><F><T><G><S><L><P><V><N><A><G><R><L><R><P><V><S><S><R><P><Q><E><T><V><Q><A><Q><S><S><R><L><L><L><L><H><P><T><A><P><S><E><A><L><G><L><P><D><L><D><L><C><L><P><A><S><S><T><P><S><A><D><S><R><P><S><C><I><G><A><A><P><L><R><P><V><S><T><S... | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.<BOP> | Q8N3J3 |
P84022 | SMAD3_HUMAN | SMAD family member 3 | Homo | <M><S><S><I><L><P><F><T><P><P><I><V><K><R><L><L><G><W><K><K><G><E><Q><N><G><Q><E><E><K><W><C><E><K><A><V><K><S><L><V><K><K><L><K><K><T><G><Q><L><D><E><L><E><K><A><I><T><T><Q><N><V><N><T><K><C><I><T><I><P><R><S><L><D><G><R><L><Q><V><S><H><R><K><G><L><P><H><V><I><Y><C><R><L><W><R><W><P><D><L><H><S><H><H><E><L><R><A><M><E... | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4... | P84022 |
Q9BUH8 | BEGIN_HUMAN | Brain-enriched guanylate kinase-associated protein | Homo | <M><E><K><L><S><A><L><Q><E><Q><K><G><E><L><R><K><R><L><S><Y><T><T><H><K><L><E><K><L><E><T><E><F><D><S><T><R><H><Y><L><E><I><E><L><R><R><A><Q><E><E><L><E><K><V><T><E><K><L><R><R><I><Q><S><N><Y><M><A><L><Q><R><I><N><Q><E><L><E><D><K><L><Y><R><M><G><Q><H><Y><E><E><E><K><R><A><L><S><H><E><I><V><A><L><N><S><H><L><L><E><A><K... | May sustain the structure of the postsynaptic density (PSD).<BOP> | Q9BUH8 |
Q5QP82 | DCA10_HUMAN | WD repeat-containing protein 32 | Homo | <M><F><P><F><G><P><H><S><P><G><G><D><G><S><A><G><A><G><A><E><E><P><T><P><H><E><G><Q><A><A><A><T><G><P><P><S><P><L><H><P><G><A><D><A><T><H><P><P><P><P><A><R><S><P><R><R><P><G><A><P><S><L><S><P><A><P><R><S><G><E><L><G><L><P><G><A><P><E><S><S><T><A><S><A><P><G><E><P><S><P><P><S><P><P><C><R><R><P><G><P><D><C><R><A><K><S><R... | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.<BOP> | Q5QP82 |
Q9UL52 | TM11E_HUMAN | Transmembrane protease serine 11E catalytic chain | Homo | <M><M><Y><R><P><D><V><V><R><A><R><K><R><V><C><W><E><P><W><V><I><G><L><V><I><F><I><S><L><I><V><L><A><V><C><I><G><L><T><V><H><Y><V><R><Y><N><Q><K><K><T><Y><N><Y><Y><S><T><L><S><F><T><T><D><K><L><Y><A><E><F><G><R><E><A><S><N><N><F><T><E><M><S><Q><R><L><E><S><M><V><K><N><A><F><Y><K><S><P><L><R><E><E><F><V><K><S><Q><V><I><K... | Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.<BOP> | Q9UL52 |
Q96R69 | OR4F4_HUMAN | Olfactory receptor OR19-3 | Homo | <M><V><T><E><F><I><F><L><G><L><S><D><S><Q><E><L><Q><T><F><L><F><M><L><F><F><V><F><Y><G><G><I><V><F><G><N><L><L><I><V><I><T><V><V><S><D><S><H><L><H><S><P><M><Y><F><L><L><A><N><L><S><L><I><D><L><S><L><S><S><V><T><A><P><K><M><I><T><D><F><F><S><Q><R><K><V><I><S><F><K><G><C><L><V><Q><I><F><L><L><H><F><F><G><G><S><E><M><V><I... | Odorant receptor.<BOP> | Q96R69 |
O60504 | VINEX_HUMAN | Sorbin and SH3 domain-containing protein 3 | Homo | <M><Q><G><P><P><R><S><L><R><A><G><L><S><L><D><D><F><I><P><G><H><L><Q><S><H><I><G><S><S><S><R><G><T><R><V><P><V><I><R><N><G><G><S><N><T><L><N><F><Q><F><H><D><P><A><P><R><T><V><C><N><G><G><Y><T><P><R><R><D><A><S><Q><H><P><D><P><A><W><Y><Q><T><W><P><G><P><G><S><K><P><S><A><S><T><K><I><P><A><S><Q><H><T><Q><N><W><S><A><T><W... | Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.<BOP> | O60504 |
O00559 | RCAS1_HUMAN | Estrogen receptor-binding fragment-associated gene 9 protein | Homo | <M><A><I><T><Q><F><R><L><F><K><F><C><T><C><L><A><T><V><F><S><F><L><K><R><L><I><C><R><S><G><R><G><R><K><L><S><G><D><Q><I><T><L><P><T><T><V><D><Y><S><S><V><P><K><Q><T><D><V><E><E><W><T><S><W><D><E><D><A><P><T><S><V><K><I><E><G><G><N><G><N><V><A><T><Q><Q><N><S><L><E><Q><L><E><P><D><Y><F><K><D><M><T><P><T><I><R><K><T><Q><K... | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.<BOP> | O00559 |
Q14257 | RCN2_HUMAN | E6-binding protein | Homo | <M><R><L><G><P><R><T><A><A><L><G><L><L><L><L><C><A><A><A><A><G><A><G><K><A><E><E><L><H><Y><P><L><G><E><R><R><S><D><Y><D><R><E><A><L><L><G><V><Q><E><D><V><D><E><Y><V><K><L><G><H><E><E><Q><Q><K><R><L><Q><A><I><I><K><K><I><D><L><D><S><D><G><F><L><T><E><S><E><L><S><S><W><I><Q><M><S><F><K><H><Y><A><M><Q><E><A><K><Q><Q><F><V... | Not known. Binds calcium.<BOP> | Q14257 |
P49910 | ZN165_HUMAN | Zinc finger and SCAN domain-containing protein 7 | Homo | <M><A><T><E><P><K><K><A><A><A><Q><N><S><P><E><D><E><G><L><L><I><V><K><I><E><E><E><E><F><I><H><G><Q><D><T><C><L><Q><R><S><E><L><L><K><Q><E><L><C><R><Q><L><F><R><Q><F><C><Y><Q><D><S><P><G><P><R><E><A><L><S><R><L><R><E><L><C><C><Q><W><L><K><P><E><I><H><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><G><D><L><Q><A... | May be involved in transcriptional regulation.<BOP> | P49910 |
P80098 | CCL7_HUMAN | Small-inducible cytokine A7 | Homo | <M><K><A><S><A><A><L><L><C><L><L><L><T><A><A><A><F><S><P><Q><G><L><A><Q><P><V><G><I><N><T><S><T><T><C><C><Y><R><F><I><N><K><K><I><P><K><Q><R><L><E><S><Y><R><R><T><T><S><S><H><C><P><R><E><A><V><I><F><K><T><K><L><D><K><E><I><C><A><D><P><T><Q><K><W><V><Q><D><F><M><K><H><L><D><K><K><T><Q><T><P><K><L> | Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.<BOP> | P80098 |
P10176 | COX8A_HUMAN | Cytochrome c oxidase subunit 8-2 | Homo | <M><S><V><L><T><P><L><L><L><R><G><L><T><G><S><A><R><R><L><P><V><P><R><A><K><I><H><S><L><P><P><E><G><K><L><G><I><M><E><L><A><V><G><L><T><S><C><F><V><T><F><L><L><P><A><G><W><I><L><S><H><L><E><T><Y><R><R><P><E> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII... | P10176 |
P51580 | TPMT_HUMAN | Thiopurine methyltransferase | Homo | <M><D><G><T><R><T><S><L><D><I><E><E><Y><S><D><T><E><V><Q><K><N><Q><V><L><T><L><E><E><W><Q><D><K><W><V><N><G><K><T><A><F><H><Q><E><Q><G><H><Q><L><L><K><K><H><L><D><T><F><L><K><G><K><S><G><L><R><V><F><F><P><L><C><G><K><A><V><E><M><K><W><F><A><D><R><G><H><S><V><V><G><V><E><I><S><E><L><G><I><Q><E><F><F><T><E><Q><N><L><S><Y... | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor . TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural ... | P51580 |
Q9NQG5 | RPR1B_HUMAN | Cell cycle-related and expression-elevated protein in tumor | Homo | <M><S><S><F><S><E><S><A><L><E><K><K><L><S><E><L><S><N><S><Q><Q><S><V><Q><T><L><S><L><W><L><I><H><H><R><K><H><A><G><P><I><V><S><V><W><H><R><E><L><R><K><A><K><S><N><R><K><L><T><F><L><Y><L><A><N><D><V><I><Q><N><S><K><R><K><G><P><E><F><T><R><E><F><E><S><V><L><V><D><A><F><S><H><V><A><R><E><A><D><E><G><C><K><K><P><L><E><R><L... | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termi... | Q9NQG5 |
Q96GX2 | A7L3B_HUMAN | Ataxin-7-like protein 3B | Homo | <M><E><E><I><S><L><A><N><L><D><T><N><K><L><E><A><I><A><Q><E><I><Y><V><D><L><I><E><D><S><C><L><G><F><C><F><E><V><H><R><A><V><K><C><G><Y><F><Y><L><E><F><A><E><T><G><S><V><K><D><F><G><I><Q><P><V><E><D><K><G><A><C><R><L><P><L><C><S><L><P><G><E><P><G><N><G><P><D><Q><Q><L><Q><R><S><P><P><E><F><Q> | By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering EN... | Q96GX2 |
Q9H4K7 | MTG2_HUMAN | Protein obg homolog 1 | Homo | <M><A><P><A><R><C><F><S><A><R><L><R><T><V><F><Q><G><V><G><H><W><A><L><S><T><W><A><G><L><K><P><S><R><L><L><P><Q><R><A><S><P><R><L><L><S><V><G><R><A><D><L><A><K><H><Q><E><L><P><G><K><K><L><L><S><E><K><K><L><K><R><Y><F><V><D><Y><R><R><V><L><V><C><G><G><N><G><G><A><G><A><S><C><F><H><S><E><P><R><K><E><F><G><G><P><D><G><G><D... | Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.<BOP> | Q9H4K7 |
O15432 | COPT2_HUMAN | Solute carrier family 31 member 2 | Homo | <M><A><M><H><F><I><F><S><D><T><A><V><L><L><F><D><F><W><S><V><H><S><P><A><G><M><A><L><S><V><L><V><L><L><L><L><A><V><L><Y><E><G><I><K><V><G><K><A><K><L><L><N><Q><V><L><V><N><L><P><T><S><I><S><Q><Q><T><I><A><E><T><D><G><D><S><A><G><S><D><S><F><P><V><G><R><T><H><H><R><W><Y><L><C><H><F><G><Q><S><L><I><H><V><I><Q><V><V><I><G... | Involved in low-affinity copper uptake.<BOP> | O15432 |
P40855 | PEX19_HUMAN | Peroxisomal farnesylated protein | Homo | <M><A><A><A><E><E><G><C><S><V><G><A><E><A><D><R><E><L><E><E><L><L><E><S><A><L><D><D><F><D><K><A><K><P><S><P><A><P><P><S><T><T><T><A><P><D><A><S><G><P><Q><K><R><S><P><G><D><T><A><K><D><A><L><F><A><S><Q><E><K><F><F><Q><E><L><F><D><S><E><L><A><S><Q><A><T><A><E><F><E><K><A><M><K><E><L><A><E><E><E><P><H><L><V><E><Q><F><Q><K... | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by ... | P40855 |
Q8NHA4 | O2AE1_HUMAN | Olfactory receptor 2AE2 | Homo | <M><W><Q><K><N><Q><T><S><L><A><D><F><I><L><E><G><L><F><D><D><S><L><T><H><L><F><L><F><S><L><T><M><V><V><F><L><I><A><V><S><G><N><T><L><T><I><L><L><I><C><I><D><P><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><L><M><H><V><S><T><I><I><L><K><M><A><T><N><Y><L><S><G><K><K><S><I><S><F><V><G><C><A><T><Q><H><F><L><Y><L><C><L... | Odorant receptor.<BOP> | Q8NHA4 |
Q8N6W0 | CELF5_HUMAN | RNA-binding protein BRUNOL-5 | Homo | <M><A><R><L><T><E><S><E><A><R><R><Q><Q><Q><Q><L><L><Q><P><R><P><S><P><V><G><S><S><G><P><E><P><P><G><G><Q><P><D><G><M><K><D><L><D><A><I><K><L><F><V><G><Q><I><P><R><H><L><D><E><K><D><L><K><P><L><F><E><Q><F><G><R><I><Y><E><L><T><V><L><K><D><P><Y><T><G><M><H><K><G><C><A><F><L><T><Y><C><A><R><D><S><A><I><K><A><Q><T><A><L><H... | RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at ... | Q8N6W0 |
Q9NP78 | ABCB9_HUMAN | TAP-like protein | Homo | <M><R><L><W><K><A><V><V><V><T><L><A><F><M><S><V><D><I><C><V><T><T><A><I><Y><V><F><S><H><L><D><R><S><L><L><E><D><I><R><H><F><N><I><F><D><S><V><L><D><L><W><A><A><C><L><Y><R><S><C><L><L><L><G><A><T><I><G><V><A><K><N><S><A><L><G><P><R><R><L><R><A><S><W><L><V><I><T><L><V><C><L><F><V><G><I><Y><A><M><V><K><L><L><L><F><S><E><V... | ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation . Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers . Binds and transports smaller and larger peptides wit... | Q9NP78 |
Q9H2H8 | PPIL3_HUMAN | Rotamase PPIL3 | Homo | <M><S><V><T><L><H><T><D><V><G><D><I><K><I><E><V><F><C><E><R><T><P><K><T><C><E><N><F><L><A><L><C><A><S><N><Y><Y><N><G><C><I><F><H><R><N><I><K><G><F><M><V><Q><T><G><D><P><T><G><T><G><R><G><G><N><S><I><W><G><K><K><F><E><D><E><Y><S><E><Y><L><K><H><N><V><R><G><V><V><S><M><A><N><N><G><P><N><T><N><G><S><Q><F><F><I><T><Y><G><K... | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.<BOP> | Q9H2H8 |
Q9NR28 | DBLOH_HUMAN | Second mitochondria-derived activator of caspase | Homo | <M><A><A><L><K><S><W><L><S><R><S><V><T><S><F><F><R><Y><R><Q><C><L><C><V><P><V><V><A><N><F><K><K><R><C><F><S><E><L><I><R><P><W><H><K><T><V><T><I><G><F><G><V><T><L><C><A><V><P><I><A><Q><K><S><E><P><H><S><L><S><S><E><A><L><M><R><R><A><V><S><L><V><T><D><S><T><S><T><F><L><S><Q><T><T><Y><A><L><I><E><A><I><T><E><Y><T><K><A><V... | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of X... | Q9NR28 |
C9J202 | AG1L2_HUMAN | Putative glycosyltransferase ALG1L2 | Homo | <M><G><A><T><A><G><W><A><V><T><V><Y><D><K><P><A><S><F><F><K><E><A><P><L><D><L><Q><H><R><L><F><M><K><L><G><S><T><H><S><P><F><R><A><R><S><E><P><E><D><P><D><T><E><R><S><A><F><T><E><R><D><S><G><S><G><L><V><T><R><L><H><E><R><P><A><L><L><V><S><S><T><S><W><T><E><F><E><Q><L><T><L><D><G><Q><N><L><P><S><L><V><C><V><I><T><G><K><G... | Putative glycosyltransferase.<BOP> | C9J202 |
Q8IYI0 | SHLD1_HUMAN | Shield complex subunit 1 | Homo | <M><A><A><R><D><A><T><S><G><S><L><S><E><E><S><S><A><L><D><L><P><S><A><C><D><I><R><D><Y><V><L><Q><G><P><S><Q><E><A><N><S><E><A><F><S><S><L><E><F><H><S><F><P><Y><S><S><D><V><D><P><D><T><S><N><L><N><I><E><Q><N><N><S><W><T><A><E><N><F><W><L><D><P><A><V><K><G><Q><S><E><K><E><E><D><D><G><L><R><K><S><L><D><R><F><Y><E><M><F><G... | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes inc... | Q8IYI0 |
A8MTJ3 | GNAT3_HUMAN | Gustducin alpha-3 chain | Homo | <M><G><S><G><I><S><S><E><S><K><E><S><A><K><R><S><K><E><L><E><K><K><L><Q><E><D><A><E><R><D><A><R><T><V><K><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><K><I><I><H><K><N><G><Y><S><E><Q><E><C><M><E><F><K><A><V><I><Y><S><N><T><L><Q><S><I><L><A><I><V><K><A><M><T><T><L><G><I><D><Y><V><N><P><R><S><A><E><D><Q><R><Q><L... | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface re... | A8MTJ3 |
Q99489 | OXDD_HUMAN | D-aspartate oxidase | Homo | <M><D><T><A><R><I><A><V><V><G><A><G><V><V><G><L><S><T><A><V><C><I><S><K><L><V><P><R><C><S><V><T><I><I><S><D><K><F><T><P><D><T><T><S><D><V><A><A><G><M><L><I><P><H><T><Y><P><D><T><P><I><H><T><Q><K><Q><W><F><R><E><T><F><N><H><L><F><A><I><A><N><S><A><E><A><G><D><A><G><V><H><L><V><S><G><W><Q><I><F><Q><S><T><P><T><E><E><V><P... | Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.<BOP> | Q99489 |
P07602 | SAP_HUMAN | Protein C | Homo | <M><Y><A><L><F><L><L><A><S><L><L><G><A><A><L><A><G><P><V><L><G><L><K><E><C><T><R><G><S><A><V><W><C><Q><N><V><K><T><A><S><D><C><G><A><V><K><H><C><L><Q><T><V><W><N><K><P><T><V><K><S><L><P><C><D><I><C><K><D><V><V><T><A><A><G><D><M><L><K><D><N><A><T><E><E><E><I><L><V><Y><L><E><K><T><C><D><W><L><P><K><P><N><M><S><A><S><C><K... | Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.<BOP> | P07602 |
Q8N668 | COMD1_HUMAN | Protein Murr1 | Homo | <M><A><A><G><E><L><E><G><G><K><P><L><S><G><L><L><N><A><L><A><Q><D><T><F><H><G><Y><P><G><I><T><E><E><L><L><R><S><Q><L><Y><P><E><V><P><P><E><E><F><R><P><F><L><A><K><M><R><G><I><L><K><S><I><A><S><A><D><M><D><F><N><Q><L><E><A><F><L><T><A><Q><T><K><K><Q><G><G><I><T><S><D><Q><A><A><V><I><S><K><F><W><K><S><H><K><T><K><I><R><E... | Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activit... | Q8N668 |
Q9UHG2 | PCS1N_HUMAN | SAAS CT(25-40) | Homo | <M><A><G><S><P><L><L><W><G><P><R><A><G><G><V><G><L><L><V><L><L><L><L><G><L><F><R><P><P><P><A><L><C><A><R><P><V><K><E><P><R><G><L><S><A><A><S><P><P><L><A><E><T><G><A><P><R><R><F><R><R><S><V><P><R><G><E><A><A><G><A><V><Q><E><L><A><R><A><L><A><H><L><L><E><A><E><R><Q><E><R><A><R><A><E><A><Q><E><A><E><D><Q><Q><A><R><V><L><A... | Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.<BOP> | Q9UHG2 |
Q99956 | DUS9_HUMAN | Mitogen-activated protein kinase phosphatase 4 | Homo | <M><E><G><L><G><R><S><C><L><W><L><R><R><E><L><S><P><P><R><P><R><L><L><L><L><D><C><R><S><R><E><L><Y><E><S><A><R><I><G><G><A><L><S><V><A><L><P><A><L><L><L><R><R><L><R><R><G><S><L><S><V><R><A><L><L><P><G><P><P><L><Q><P><P><P><P><A><P><V><L><L><Y><D><Q><G><G><G><R><R><R><R><G><E><A><E><A><E><A><E><E><W><E><A><E><S><V><L><G... | Inactivates MAP kinases. Has a specificity for the ERK family.<BOP> | Q99956 |
Q8WUA7 | TB22A_HUMAN | TBC1 domain family member 22A | Homo | <M><A><S><D><G><A><R><K><Q><F><W><K><R><S><N><S><K><L><P><G><S><I><Q><H><V><Y><G><A><Q><H><P><P><F><D><P><L><L><H><G><T><L><L><R><S><T><A><K><M><P><T><T><P><V><K><A><K><R><V><S><T><F><Q><E><F><E><S><N><T><S><D><A><W><D><A><G><E><D><D><D><E><L><L><A><M><A><A><E><S><L><N><S><E><V><V><M><E><T><A><N><R><V><L><R><N><H><S><Q... | May act as a GTPase-activating protein for Rab family protein(s).<BOP> | Q8WUA7 |
O15126 | SCAM1_HUMAN | Secretory carrier-associated membrane protein 1 | Homo | <M><S><D><F><D><S><N><P><F><A><D><P><D><L><N><N><P><F><K><D><P><S><V><T><Q><V><T><R><N><V><P><P><G><L><D><E><Y><N><P><F><S><D><S><R><T><P><P><P><G><G><V><K><M><P><N><V><P><N><T><Q><P><A><I><M><K><P><T><E><E><H><P><A><Y><T><Q><I><A><K><E><H><A><L><A><Q><A><E><L><L><K><R><Q><E><E><L><E><R><K><A><A><E><L><D><R><R><E><R><E... | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.<BOP> | O15126 |
Q96G91 | P2Y11_HUMAN | P2Y purinoceptor 11 | Homo | <M><A><A><N><V><S><G><A><K><S><C><P><A><N><F><L><A><A><A><D><D><K><L><S><G><F><Q><G><D><F><L><W><P><I><L><V><V><E><F><L><V><A><V><A><S><N><G><L><A><L><Y><R><F><S><I><R><K><Q><R><P><W><H><P><A><V><V><F><S><V><Q><L><A><V><S><D><L><L><C><A><L><T><L><P><P><L><A><A><Y><L><Y><P><P><K><H><W><R><Y><G><E><A><A><C><R><L><E><R><F... | Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.<BOP> | Q96G91 |
Q9UBZ4 | APEX2_HUMAN | Apurinic-apyrimidinic endonuclease 2 | Homo | <M><L><R><V><V><S><W><N><I><N><G><I><R><R><P><L><Q><G><V><A><N><Q><E><P><S><N><C><A><A><V><A><V><G><R><I><L><D><E><L><D><A><D><I><V><C><L><Q><E><T><K><V><T><R><D><A><L><T><E><P><L><A><I><V><E><G><Y><N><S><Y><F><S><F><S><R><N><R><S><G><Y><S><G><V><A><T><F><C><K><D><N><A><T><P><V><A><A><E><E><G><L><S><G><L><F><A><T><Q><N... | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generatin... | Q9UBZ4 |
Q96QA5 | GSDMA_HUMAN | Gasdermin-A, C-terminal | Homo | <M><T><M><F><E><N><V><T><R><A><L><A><R><Q><L><N><P><R><G><D><L><T><P><L><D><S><L><I><D><F><K><R><F><H><P><F><C><L><V><L><R><K><R><K><S><T><L><F><W><G><A><R><Y><V><R><T><D><Y><T><L><L><D><V><L><E><P><G><S><S><P><S><D><P><T><D><T><G><N><F><G><F><K><N><M><L><D><T><R><V><E><G><D><V><D><V><P><K><T><V><K><V><K><G><T><A><G><L... | Pore-forming protein that causes membrane permeabilization and pyroptosis . Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids . Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Binds to memb... | Q96QA5 |
Q9UBU6 | FA8A1_HUMAN | Autosomal highly conserved protein | Homo | <M><A><E><G><P><E><E><A><R><G><H><P><P><G><Q><D><D><G><G><G><D><H><E><P><V><P><S><L><R><G><P><P><T><T><A><V><P><C><P><R><D><D><P><Q><A><E><P><Q><A><P><G><R><P><T><A><P><G><L><A><A><A><A><A><A><D><K><L><E><P><P><R><E><L><R><K><R><G><E><A><A><S><G><S><G><A><E><L><Q><E><Q><A><G><C><E><A><P><E><A><A><A><P><R><E><R><P><A><R... | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD).<BOP> | Q9UBU6 |
Q12996 | CSTF3_HUMAN | Cleavage stimulation factor 77 kDa subunit | Homo | <M><S><G><D><G><A><T><E><Q><A><A><E><Y><V><P><E><K><V><K><K><A><E><K><K><L><E><E><N><P><Y><D><L><D><A><W><S><I><L><I><R><E><A><Q><N><Q><P><I><D><K><A><R><K><T><Y><E><R><L><V><A><Q><F><P><S><S><G><R><F><W><K><L><Y><I><E><A><E><I><K><A><K><N><Y><D><K><V><E><K><L><F><Q><R><C><L><M><K><V><L><H><I><D><L><W><K><C><Y><L><S><Y... | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.<BOP> | Q12996 |
Q16877 | F264_HUMAN | Fructose-2,6-bisphosphatase | Homo | <M><A><S><P><R><E><L><T><Q><N><P><L><K><K><I><W><M><P><Y><S><N><G><R><P><A><L><H><A><C><Q><R><G><V><C><M><T><N><C><P><T><L><I><V><M><V><G><L><P><A><R><G><K><T><Y><I><S><K><K><L><T><R><Y><L><N><W><I><G><V><P><T><R><E><F><N><V><G><Q><Y><R><R><D><V><V><K><T><Y><K><S><F><E><F><F><L><P><D><N><E><E><G><L><K><I><R><K><Q><C><A... | Synthesis and degradation of fructose 2,6-bisphosphate.<BOP> | Q16877 |
Q9BYE7 | PCGF6_HUMAN | RING finger protein 134 | Homo | <M><E><G><V><A><V><V><T><A><G><S><V><G><A><A><K><T><E><G><A><A><A><L><P><P><P><P><P><V><S><P><P><A><L><T><P><A><P><A><A><G><E><E><G><P><A><P><L><S><E><T><G><A><P><G><C><S><G><S><R><P><P><E><L><E><P><E><R><S><L><G><R><F><R><G><R><F><E><D><E><D><E><E><L><E><E><E><E><E><L><E><E><E><E><E><E><E><E><E><D><M><S><H><F><S><L><R... | Transcriptional repressor . May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase . Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG... | Q9BYE7 |
P01877 | IGHA2_HUMAN | Ig alpha-2 chain C region LAN | Homo | <A><S><P><T><S><P><K><V><F><P><L><S><L><D><S><T><P><Q><D><G><N><V><V><V><A><C><L><V><Q><G><F><F><P><Q><E><P><L><S><V><T><W><S><E><S><G><Q><N><V><T><A><R><N><F><P><P><S><Q><D><A><S><G><D><L><Y><T><T><S><S><Q><L><T><L><P><A><T><Q><C><P><D><G><K><S><V><T><C><H><V><K><H><Y><T><N><S><S><Q><D><V><T><V><P><C><R><V><P><P><P><P... | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the cl... | P01877 |
P29017 | CD1C_HUMAN | T-cell surface glycoprotein CD1c | Homo | <M><L><F><L><Q><F><L><L><L><A><L><L><L><P><G><G><D><N><A><D><A><S><Q><E><H><V><S><F><H><V><I><Q><I><F><S><F><V><N><Q><S><W><A><R><G><Q><G><S><G><W><L><D><E><L><Q><T><H><G><W><D><S><E><S><G><T><I><I><F><L><H><N><W><S><K><G><N><F><S><N><E><E><L><S><D><L><E><L><L><F><R><F><Y><L><F><G><L><T><R><E><I><Q><D><H><A><S><Q><D><Y... | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<BOP> | P29017 |
Q96C57 | CSTOS_HUMAN | Protein CUSTOS | Homo | <M><A><A><P><S><G><T><V><S><D><S><E><S><S><N><S><S><S><D><A><E><E><L><E><R><C><R><E><A><A><M><P><A><W><G><L><E><Q><R><P><H><V><A><G><K><P><R><A><G><A><A><N><S><Q><L><S><T><S><Q><P><S><L><R><H><K><V><N><E><H><E><Q><D><G><N><E><L><Q><T><T><P><E><F><R><A><H><V><A><K><K><L><G><A><L><L><D><S><F><I><T><I><S><E><A><A><K><E><P... | Plays a role in the regulation of Wnt signaling pathway during early development.<BOP> | Q96C57 |
Q9Y3Y2 | CHTOP_HUMAN | Small arginine- and glycine-rich protein | Homo | <M><A><A><Q><S><A><P><K><V><V><L><K><S><T><T><K><M><S><L><N><E><R><F><T><N><M><L><K><N><K><Q><P><T><P><V><N><I><R><A><S><M><Q><Q><Q><Q><Q><L><A><S><A><R><N><R><R><L><A><Q><Q><M><E><N><R><P><S><V><Q><A><A><L><K><L><K><Q><S><L><K><Q><R><L><G><K><S><N><I><Q><A><R><L><G><R><P><I><G><A><L><A><R><G><A><I><G><G><R><G><L><P><I... | Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, bind... | Q9Y3Y2 |
P49765 | VEGFB_HUMAN | VEGF-related factor | Homo | <M><S><P><L><L><R><R><L><L><L><A><A><L><L><Q><L><A><P><A><Q><A><P><V><S><Q><P><D><A><P><G><H><Q><R><K><V><V><S><W><I><D><V><Y><T><R><A><T><C><Q><P><R><E><V><V><V><P><L><T><V><E><L><M><G><T><V><A><K><Q><L><V><P><S><C><V><T><V><Q><R><C><G><G><C><C><P><D><D><G><L><E><C><V><P><T><G><Q><H><Q><V><R><M><Q><I><L><M><I><R><Y><P... | Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.<BOP> | P49765 |
O76093 | FGF18_HUMAN | zFGF5 | Homo | <M><Y><S><A><P><S><A><C><T><C><L><C><L><H><F><L><L><L><C><F><Q><V><Q><V><L><V><A><E><E><N><V><D><F><R><I><H><V><E><N><Q><T><R><A><R><D><D><V><S><R><K><Q><L><R><L><Y><Q><L><Y><S><R><T><S><G><K><H><I><Q><V><L><G><R><R><I><S><A><R><G><E><D><G><D><K><Y><A><Q><L><L><V><E><T><D><T><F><G><S><Q><V><R><I><K><G><K><E><T><E><F><Y... | Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.<BOP> | O76093 |
P58182 | O12D2_HUMAN | Olfactory receptor OR6-28 | Homo | <M><L><N><T><T><S><V><T><E><F><L><L><L><G><V><T><D><I><Q><E><L><Q><P><F><L><F><V><V><F><L><T><I><Y><F><I><S><V><T><G><N><G><A><V><L><M><I><V><I><S><D><P><R><L><H><S><L><M><Y><F><F><L><G><N><L><S><Y><L><D><I><C><Y><S><T><V><T><L><P><K><M><L><Q><N><F><L><S><T><H><K><A><I><S><F><L><G><C><I><S><Q><L><H><F><F><H><S><L><G><S... | Odorant receptor.<BOP> | P58182 |
P12018 | VPREB_HUMAN | V(pre)B protein | Homo | <M><S><W><A><P><V><L><L><M><L><F><V><Y><C><T><G><C><G><P><Q><P><V><L><H><Q><P><P><A><M><S><S><A><L><G><T><T><I><R><L><T><C><T><L><R><N><D><H><D><I><G><V><Y><S><V><Y><W><Y><Q><Q><R><P><G><H><P><P><R><F><L><L><R><Y><F><S><Q><S><D><K><S><Q><G><P><Q><V><P><P><R><F><S><G><S><K><D><V><A><R><N><R><G><Y><L><S><I><S><E><L><Q><P... | Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.<BOP> | P12018 |
Q6ZN68 | D19P2_HUMAN | Protein dpy-19 homolog 2-like 2 | Homo | <M><A><D><S><R><R><V><I><I><A><S><W><Y><R><T><F><M><G><I><V><N><L><F><G><L><E><T><K><T><C><W><N><V><T><R><I><E><P><L><N><E><V><Q><S><C><E><G><L><R><D><P><A><C><F><Y><V><G><V><I><F><I><L><N><G><L><M><M><G><L><F><F><I><Y><G><T><Y><L><S><G><T><E><L><G><G><L><I><T><V><L><C><F><F><F><N><H><G><E><A><T><C><V><M><W><T><P><P><L... | Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.<BOP> | Q6ZN68 |
P07947 | YES_HUMAN | p61-Yes | Homo | <M><G><C><I><K><S><K><E><N><K><S><P><A><I><K><Y><R><P><E><N><T><P><E><P><V><S><T><S><V><S><H><Y><G><A><E><P><T><T><V><S><P><C><P><S><S><S><A><K><G><T><A><V><N><F><S><S><L><S><M><T><P><F><G><G><S><S><G><V><T><P><F><G><G><A><S><S><S><F><S><V><V><P><S><S><Y><P><A><G><L><T><G><G><V><T><I><F><V><A><L><Y><D><Y><E><A><R><T><T... | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated recep... | P07947 |
Q96EH3 | MASU1_HUMAN | Mitochondrial assembly of ribosomal large subunit protein 1 | Homo | <M><G><P><G><G><R><V><A><R><L><L><A><P><L><M><W><R><R><A><V><S><S><V><A><G><S><A><V><G><A><E><P><G><L><R><L><L><A><V><Q><R><L><P><V><G><A><A><F><C><R><A><C><Q><T><P><N><F><V><R><G><L><H><S><E><P><G><L><E><E><R><A><E><G><T><V><N><E><G><R><P><E><S><D><A><A><D><H><T><G><P><K><F><D><I><D><M><M><V><S><L><L><R><Q><E><N><A><R... | Required for normal mitochondrial ribosome function and mitochondrial translation . May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge... | Q96EH3 |
Q9NYL5 | CP39A_HUMAN | Oxysterol 7-alpha-hydroxylase | Homo | <M><E><L><I><S><P><T><V><I><I><I><L><G><C><L><A><L><F><L><L><L><Q><R><K><N><L><R><R><P><P><C><I><K><G><W><I><P><W><I><G><V><G><F><E><F><G><K><A><P><L><E><F><I><E><K><A><R><I><K><Y><G><P><I><F><T><V><F><A><M><G><N><R><M><T><F><V><T><E><E><E><G><I><N><V><F><L><K><S><K><K><V><D><F><E><L><A><V><Q><N><I><V><Y><R><T><A><S><I... | A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis . Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and r... | Q9NYL5 |
Q16558 | KCMB1_HUMAN | Slo-beta-1 | Homo | <M><V><K><K><L><V><M><A><Q><K><R><G><E><T><R><A><L><C><L><G><V><T><M><V><V><C><A><V><I><T><Y><Y><I><L><V><T><T><V><L><P><L><Y><Q><K><S><V><W><T><Q><E><S><K><C><H><L><I><E><T><N><I><R><D><Q><E><E><L><K><G><K><K><V><P><Q><Y><P><C><L><W><V><N><V><S><A><A><G><R><W><A><V><L><Y><H><T><E><D><T><R><D><Q><N><Q><Q><C><S><Y><I><P... | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters it... | Q16558 |
Q8IVS2 | FABD_HUMAN | [Acyl-carrier-protein] malonyltransferase | Homo | <M><S><V><R><V><A><R><V><A><W><V><R><G><L><G><A><S><Y><R><R><G><A><S><S><F><P><V><P><P><P><G><A><Q><G><V><A><E><L><L><R><D><A><T><G><A><E><E><E><A><P><W><A><A><T><E><R><R><M><P><G><Q><C><S><V><L><L><F><P><G><Q><G><S><Q><V><V><G><M><G><R><G><L><L><N><Y><P><R><V><R><E><L><Y><A><A><A><R><R><V><L><G><Y><D><L><L><E><L><S><L... | Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria.<BOP> | Q8IVS2 |
P05452 | TETN_HUMAN | Plasminogen kringle 4-binding protein | Homo | <M><E><L><W><G><A><Y><L><L><L><C><L><F><S><L><L><T><Q><V><T><T><E><P><P><T><Q><K><P><K><K><I><V><N><A><K><K><D><V><V><N><T><K><M><F><E><E><L><K><S><R><L><D><T><L><A><Q><E><V><A><L><L><K><E><Q><Q><A><L><Q><T><V><C><L><K><G><T><K><V><H><M><K><C><F><L><A><F><T><Q><T><K><T><F><H><E><A><S><E><D><C><I><S><R><G><G><T><L><G><T... | Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.<BOP> | P05452 |
P01624 | KV315_HUMAN | Ig kappa chain V-III region POM | Homo | <M><E><A><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><G><E><I><V><M><T><Q><S><P><A><T><L><S><V><S><P><G><E><R><A><T><L><S><C><R><A><S><Q><S><V><S><S><N><L><A><W><Y><Q><Q><K><P><G><Q><A><P><R><L><L><I><Y><G><A><S><T><R><A><T><G><I><P><A><R><F><S><G><S><G><S><G><T><E><F><T><L><T><I><S><S><L><Q><S><E><D><F><A><V><Y><Y... | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P01624 |
Q15326 | ZMY11_HUMAN | Protein BS69 | Homo | <M><A><R><L><T><K><R><R><Q><A><D><T><K><A><I><Q><H><L><W><A><A><I><E><I><I><R><N><Q><K><Q><I><A><N><I><D><R><I><T><K><Y><M><S><R><V><H><G><M><H><P><K><E><T><T><R><Q><L><S><L><A><V><K><D><G><L><I><V><E><T><L><T><V><G><C><K><G><S><K><A><G><I><E><Q><E><G><Y><W><L><P><G><D><E><I><D><W><E><T><E><N><H><D><W><Y><C><F><E><C><H... | (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.<BOP> | Q15326 |
Q9GZL7 | WDR12_HUMAN | WD repeat-containing protein 12 | Homo | <M><A><Q><L><Q><T><R><F><Y><T><D><N><K><K><Y><A><V><D><D><V><P><F><S><I><P><A><A><S><E><I><A><D><L><S><N><I><I><N><K><L><L><K><D><K><N><E><F><H><K><H><V><E><F><D><F><L><I><K><G><Q><F><L><R><M><P><L><D><K><H><M><E><M><E><N><I><S><S><E><E><V><V><E><I><E><Y><V><E><K><Y><T><A><P><Q><P><E><Q><C><M><F><H><D><D><W><I><S><S><I... | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.<BOP> | Q9GZL7 |
Q9GZY6 | NTAL_HUMAN | Williams-Beuren syndrome chromosomal region 5 protein | Homo | <M><S><S><G><T><E><L><L><W><P><G><A><A><L><L><V><L><L><G><V><A><A><S><L><C><V><R><C><S><R><P><G><A><K><R><S><E><K><I><Y><Q><Q><R><S><L><R><E><D><Q><Q><S><F><T><G><S><R><T><Y><S><L><V><G><Q><A><W><P><G><P><L><A><D><M><A><P><T><R><K><D><K><L><L><Q><F><Y><P><S><L><E><D><P><A><S><S><R><Y><Q><N><F><S><K><G><S><R><H><G><S><E... | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors ... | Q9GZY6 |
O75586 | MED6_HUMAN | Renal carcinoma antigen NY-REN-28 | Homo | <M><A><A><V><D><I><R><D><N><L><L><G><I><S><W><V><D><S><S><W><I><P><I><L><N><S><G><S><V><L><D><Y><F><S><E><R><S><N><P><F><Y><D><R><T><C><N><N><E><V><V><K><M><Q><R><L><T><L><E><H><L><N><Q><M><V><G><I><E><Y><I><L><L><H><A><Q><E><P><I><L><F><I><I><R><K><Q><Q><R><Q><S><P><A><Q><V><I><P><L><A><D><Y><Y><I><I><A><G><V><I><Y><Q... | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters... | O75586 |
Q9Y3E1 | HDGR3_HUMAN | Hepatoma-derived growth factor 2 | Homo | <M><A><R><P><R><P><R><E><Y><K><A><G><D><L><V><F><A><K><M><K><G><Y><P><H><W><P><A><R><I><D><E><L><P><E><G><A><V><K><P><P><A><N><K><Y><P><I><F><F><F><G><T><H><E><T><A><F><L><G><P><K><D><L><F><P><Y><K><E><Y><K><D><K><F><G><K><S><N><K><R><K><G><F><N><E><G><L><W><E><I><E><N><N><P><G><V><K><F><T><G><Y><Q><A><I><Q><Q><Q><S><S... | Enhances DNA synthesis and may play a role in cell proliferation.<BOP> | Q9Y3E1 |
Q9HAI6 | TASL_HUMAN | TLR adapter interacting with SLC15A4 on the lysosome | Homo | <M><L><S><E><G><Y><L><S><G><L><E><Y><W><N><D><I><H><W><S><C><A><S><Y><N><E><Q><V><A><G><E><K><E><E><E><T><N><S><V><A><T><L><S><Y><S><S><V><D><E><T><Q><V><R><S><L><Y><V><S><C><K><S><S><G><K><F><I><S><S><V><H><S><R><E><S><Q><H><S><R><S><Q><R><V><T><V><L><Q><T><N><P><N><P><V><F><E><S><P><N><L><A><A><V><E><I><C><R><D><A><S... | Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 . Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activa... | Q9HAI6 |
P08253 | MMP2_HUMAN | PEX | Homo | <M><E><A><L><M><A><R><G><A><L><T><G><P><L><R><A><L><C><L><L><G><C><L><L><S><H><A><A><A><A><P><S><P><I><I><K><F><P><G><D><V><A><P><K><T><D><K><E><L><A><V><Q><Y><L><N><T><F><Y><G><C><P><K><E><S><C><N><L><F><V><L><K><D><T><L><K><K><M><Q><K><F><F><G><L><P><Q><T><G><D><L><D><Q><N><T><I><E><T><M><R><K><P><R><C><G><N><P><D><V... | Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.<BOP> | P08253 |
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