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scifact-qrel-31715818 | Generate text that supports or refutes this claim: 0-dimensional biomaterials show inductive properties. | New opportunities: the use of nanotechnologies to manipulate and track stem cells.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, c... |
scifact-qrel-14717500 | Generate text that supports or refutes this claim: 1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. | Rare Variants Create Synthetic Genome-Wide Associations
Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been convincingly replicated. It is generally thought... |
scifact-qrel-13734012 | Generate text that supports or refutes this claim: 1/2000 in UK have abnormal PrP positivity. | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey
OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the... |
scifact-qrel-1606628 | Generate text that supports or refutes this claim: 5% of perinatal mortality is due to low birth weight. | Estimates of global prevalence of childhood underweight in 1990 and 2015.
CONTEXT One key target of the United Nations Millennium Development goals is to reduce the prevalence of underweight among children younger than 5 years by half between 1990 and 2015. OBJECTIVE To estimate trends in childhood underweight by geogr... |
scifact-qrel-5152028 | Generate text that supports or refutes this claim: A deficiency of vitamin B12 increases blood levels of homocysteine. | Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact t... |
scifact-qrel-11705328 | Generate text that supports or refutes this claim: A deficiency of vitamin B12 increases blood levels of homocysteine. | Randomized trial of folic acid supplementation and serum homocysteine levels.
BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevant... |
scifact-qrel-18174210 | Generate text that supports or refutes this claim: A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia
BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for ... |
scifact-qrel-13734012 | Generate text that supports or refutes this claim: A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey
OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the... |
scifact-qrel-5953485 | Generate text that supports or refutes this claim: ADAR1 binds to Dicer to cleave pre-miRNA. | ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechan... |
scifact-qrel-12580014 | Generate text that supports or refutes this claim: AIRE is expressed in some skin tumors. | Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia. We report that autoimmune regulator (Ai... |
scifact-qrel-45638119 | Generate text that supports or refutes this claim: ALDH1 expression is associated with better breast cancer outcomes. | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo exper... |
scifact-qrel-45638119 | Generate text that supports or refutes this claim: ALDH1 expression is associated with poorer prognosis in breast cancer. | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo exper... |
scifact-qrel-49556906 | Generate text that supports or refutes this claim: AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. | Metformin reverses established lung fibrosis in a bleomycin model
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2-4. AMPK is a critical sensor of... |
scifact-qrel-4709641 | Generate text that supports or refutes this claim: APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using huma... |
scifact-qrel-4709641 | Generate text that supports or refutes this claim: APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using huma... |
scifact-qrel-5956380 | Generate text that supports or refutes this claim: Activation of PPM1D suppresses p53 function. | Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem glioma... |
scifact-qrel-4414547 | Generate text that supports or refutes this claim: Activation of PPM1D suppresses p53 function. | Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and rep... |
scifact-qrel-6076903 | Generate text that supports or refutes this claim: Activator-inhibitor pairs are provided dorsally by Admpchordin. | Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field
Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We discovered that quadruple knockdown of ADMP and BMP2/4/7... |
scifact-qrel-4387784 | Generate text that supports or refutes this claim: Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. | Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essentia... |
scifact-qrel-1215116 | Generate text that supports or refutes this claim: Albendazole is used to treat lymphatic filariasis. | “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reduction... |
scifact-qrel-18810195 | Generate text that supports or refutes this claim: Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. | Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic ... |
scifact-qrel-4381486 | Generate text that supports or refutes this claim: All hematopoietic stem cells segregate their chromosomes randomly. | Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing divisions so that older (‘immortal’) DNA strands are retained in daughter stem cells whereas newly synthesized strands segregate to differentiating ce... |
scifact-qrel-6157837 | Generate text that supports or refutes this claim: Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. | Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.
Angiotensin converting enzyme (ACE) inhibitors are now one of the... |
scifact-qrel-33872649 | Generate text that supports or refutes this claim: Anthrax spores can be disposed of easily after they are dispersed. | Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capi... |
scifact-qrel-6372244 | Generate text that supports or refutes this claim: Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile | Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Antibiotics can have significant and long-lasting effects on the gastrointestinal tract microbiota, reducing colonization resistance against pathogens including Clostridium difficile. Here we ... |
scifact-qrel-4883040 | Generate text that supports or refutes this claim: Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. | Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis
BACKGROUND Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estima... |
scifact-qrel-21598000 | Generate text that supports or refutes this claim: Arginine 90 in p150n is important for interaction with EB1. | Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.
Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by forming a plus-end complex at microtubule growing ends with ill-de... |
scifact-qrel-8290953 | Generate text that supports or refutes this claim: Arterioles have a larger lumen diameter than venules. | Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.
BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the damaged ti... |
scifact-qrel-27768226 | Generate text that supports or refutes this claim: Articles published in open access format are less likely to be cited than traditional journals. | Open Access Increases Citation Rate
PLoS Biology publishes today a research article by Gunther Eysenbach that is not about biology. It is about citations. It provides robust evidence that open-access articles (OA articles) are more immediately recognized and cited than non-OA articles. As such, it adds objective suppor... |
scifact-qrel-27768226 | Generate text that supports or refutes this claim: Articles published in open access format are more likely to be cited than traditional journals. | Open Access Increases Citation Rate
PLoS Biology publishes today a research article by Gunther Eysenbach that is not about biology. It is about citations. It provides robust evidence that open-access articles (OA articles) are more immediately recognized and cited than non-OA articles. As such, it adds objective suppor... |
scifact-qrel-7975937 | Generate text that supports or refutes this claim: Aspirin inhibits the production of PGE2. | Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity remain incompletely understood. Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their producti... |
scifact-qrel-38485364 | Generate text that supports or refutes this claim: Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. | The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.
Tks5/Fish is a scaffolding protein with five SH3 domains and one PX domain. In Src-transformed cells, Tks5/Fish localizes to podosomes, discrete protrusions of the ventral membrane. We ge... |
scifact-qrel-6969753 | Generate text that supports or refutes this claim: Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. | Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.
Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membra... |
scifact-qrel-17934082 | Generate text that supports or refutes this claim: Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. | Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis
Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes are structures functionally similar to invadopodia that are found in oncogene-transformed fibroblasts and monocyte-d... |
scifact-qrel-16280642 | Generate text that supports or refutes this claim: Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. | Sequential signals toward podosome formation in NIH-src cells
Podosomes (also termed invadopodia in cancer cells) are actin-rich adhesion structures with matrix degradation activity that develop in various cell types. Despite their significant physiological importance, the molecular mechanism of podosome formation is l... |
scifact-qrel-12640810 | Generate text that supports or refutes this claim: Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. | Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodi... |
scifact-qrel-26016929 | Generate text that supports or refutes this claim: Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. | Effectiveness of screening older people for impaired vision in community setting: systematic review of evidence from randomised controlled trials.
OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of randomi... |
scifact-qrel-6955746 | Generate text that supports or refutes this claim: Auditory entrainment is strengthened when people see congruent visual and auditory information. | Auditory Cortex Tracks Both Auditory and Visual Stimulus Dynamics Using Low-Frequency Neuronal Phase Modulation
Integrating information across sensory domains to construct a unified representation of multi-sensory signals is a fundamental characteristic of perception in ecological contexts. One provocative hypothesis d... |
scifact-qrel-14437255 | Generate text that supports or refutes this claim: Auditory entrainment is strengthened when people see congruent visual and auditory information. | Congruent Visual Speech Enhances Cortical Entrainment to Continuous Auditory Speech in Noise-Free Conditions.
UNLABELLED Congruent audiovisual speech enhances our ability to comprehend a speaker, even in noise-free conditions. When incongruent auditory and visual information is presented concurrently, it can hinder a l... |
scifact-qrel-10582939 | Generate text that supports or refutes this claim: Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-qrel-10582939 | Generate text that supports or refutes this claim: Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-qrel-10582939 | Generate text that supports or refutes this claim: Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-qrel-1084345 | Generate text that supports or refutes this claim: Autophagy declines in aged organisms. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We h... |
scifact-qrel-18872233 | Generate text that supports or refutes this claim: Bariatric surgery has a positive impact on mental health. | Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.
IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surgery; ho... |
scifact-qrel-12670680 | Generate text that supports or refutes this claim: Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). | BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their h... |
scifact-qrel-16322674 | Generate text that supports or refutes this claim: Birth-weight is positively associated with breast cancer. | Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies
BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant da... |
scifact-qrel-27123743 | Generate text that supports or refutes this claim: Birth-weight is positively associated with breast cancer. | Role of birthweight in the etiology of breast cancer.
Breast cancer may originate in utero. We reviewed the available evidence on the association between birthweight and the risk of breast cancer. To date, 26 research papers addressing this issue have been published. The majority of studies identified a positive link b... |
scifact-qrel-23557241 | Generate text that supports or refutes this claim: Birth-weight is positively associated with breast cancer. | Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.
BACKGROUND Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of maternal... |
scifact-qrel-17450673 | Generate text that supports or refutes this claim: Birth-weight is positively associated with breast cancer. | Intrauterine environments and breast cancer risk: meta-analysis and systematic review
INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal env... |
scifact-qrel-16966326 | Generate text that supports or refutes this claim: Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. | The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity
Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological featu... |
scifact-qrel-12827098 | Generate text that supports or refutes this claim: Bone marrow cells contribute to adult macrophage compartments. | Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and f... |
scifact-qrel-18340282 | Generate text that supports or refutes this claim: Breast cancer development is determined exclusively by genetic factors. | Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthro... |
scifact-qrel-2177022 | Generate text that supports or refutes this claim: CCL19 is absent within dLNs. | Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.
Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, w... |
scifact-qrel-13519661 | Generate text that supports or refutes this claim: CHEK2 is not associated with breast cancer. | Linkage Disequilibrium Mapping of CHEK2: Common Variation and Breast Cancer Risk
Background Checkpoint kinase 2 (CHEK2) averts cancer development by promoting cell cycle arrest and activating DNA repair in genetically damaged cells. Previous investigation has established a role for the CHEK2 gene in breast c... |
scifact-qrel-22038539 | Generate text that supports or refutes this claim: CR is associated with higher methylation age. | Caloric restriction delays age-related methylation drift
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sit... |
scifact-qrel-13625993 | Generate text that supports or refutes this claim: CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. | Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery
OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients ... |
scifact-qrel-21366394 | Generate text that supports or refutes this claim: CX3CR1 on the Th2 cells impairs T cell survival | CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airwa... |
scifact-qrel-21366394 | Generate text that supports or refutes this claim: CX3CR1 on the Th2 cells promotes T cell survival | CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airwa... |
scifact-qrel-21366394 | Generate text that supports or refutes this claim: CX3CR1 on the Th2 cells promotes airway inflammation. | CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airwa... |
scifact-qrel-21366394 | Generate text that supports or refutes this claim: CX3CR1 on the Th2 cells suppresses airway inflammation. | CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airwa... |
scifact-qrel-3067015 | Generate text that supports or refutes this claim: Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries. | Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach
BACKGROUND Alcohol has been reported to be a common and modifiable risk factor for hypertension. However, observational studies are subject to confounding by other behavioural and sociodemographic factors, while clini... |
scifact-qrel-10536636 | Generate text that supports or refutes this claim: Cataract and trachoma are the primary cause of blindness in Southern Sudan. | Prevalence and Causes of Blindness and Low Vision in Southern Sudan
Background Blindness and low vision are thought to be common in southern Sudan. However, the magnitude and geographical distribution are largely unknown. We aimed to estimate the prevalence of blindness and low vision, identify the main causes of blin... |
scifact-qrel-4388470 | Generate text that supports or refutes this claim: Cell autonomous sex determination in somatic cells does not occur in Galliformes. | Somatic sex identity is cell-autonomous in the chicken
In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to be est... |
scifact-qrel-4388470 | Generate text that supports or refutes this claim: Cell autonomous sex determination in somatic cells occurs in Passeriformes. | Somatic sex identity is cell-autonomous in the chicken
In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to be est... |
scifact-qrel-4942718 | Generate text that supports or refutes this claim: Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis. | High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis
The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half... |
scifact-qrel-2251426 | Generate text that supports or refutes this claim: Cells undergoing methionine restriction may activate miRNAs. | microRNAs: A Safeguard against Turmoil?
Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during str... |
scifact-qrel-14079881 | Generate text that supports or refutes this claim: Cellular aging closely links to an older appearance. | Perceived age as clinically useful biomarker of ageing: cohort study.
OBJECTIVE To determine whether perceived age correlates with survival and important age related phenotypes. DESIGN Follow-up study, with survival of twins determined up to January 2008, by which time 675 (37%) had died. SETTING Population based twin ... |
scifact-qrel-1568684 | Generate text that supports or refutes this claim: Chenodeosycholic acid treatment increases whole-body energy expenditure. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyron... |
scifact-qrel-1568684 | Generate text that supports or refutes this claim: Chenodeosycholic acid treatment reduces whole-body energy expenditure. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyron... |
scifact-qrel-1122279 | Generate text that supports or refutes this claim: Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training.
BACKGROUND Endothelium-dependent modulation of coronary tone is impaired in the collateral-dependent coronary microcirculation. We used a porcine model of chronic coronary occlusion and collateral development to... |
scifact-qrel-10697096 | Generate text that supports or refutes this claim: Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. | Vasodilator responses of coronary resistance arteries of exercise-trained pigs.
BACKGROUND The purpose of this study was to test the hypothesis that vasodilator responses of porcine coronary resistance arteries are increased by exercise training. METHODS AND RESULTS Yucatan miniature swine were randomly divided into gr... |
scifact-qrel-970012 | Generate text that supports or refutes this claim: Cold exposure increases BAT recruitment. | Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-densit... |
scifact-qrel-970012 | Generate text that supports or refutes this claim: Cold exposure reduces BAT recruitment. | Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-densit... |
scifact-qrel-11614737 | Generate text that supports or refutes this claim: Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy. | Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; comb... |
scifact-qrel-4961038 | Generate text that supports or refutes this claim: Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. | Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers
Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They are most frequently observed in two hotspots: the helical domain (... |
scifact-qrel-14241418 | Generate text that supports or refutes this claim: Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. | NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.
Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue delete... |
scifact-qrel-14819804 | Generate text that supports or refutes this claim: Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. | Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
The novel phosphatidylinositol-3-kinase (PI3K) inhibitor PX-866 was tested against 13 experimental human tumor xenografts derived from cell lines of... |
scifact-qrel-14376683 | Generate text that supports or refutes this claim: Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs. | Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.
The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized the vir... |
scifact-qrel-10874408 | Generate text that supports or refutes this claim: Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae. | Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae
DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break processin... |
scifact-qrel-20310709 | Generate text that supports or refutes this claim: Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis. | The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells
Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (... |
scifact-qrel-39381118 | Generate text that supports or refutes this claim: Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis. | At the gates of death.
Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential step is controlled and mediated by proteins of the Bcl-2 fam... |
scifact-qrel-3553087 | Generate text that supports or refutes this claim: Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake. | Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility ... |
scifact-qrel-4388470 | Generate text that supports or refutes this claim: DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region. | Somatic sex identity is cell-autonomous in the chicken
In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to be est... |
scifact-qrel-6173523 | Generate text that supports or refutes this claim: De novo assembly of sequence data has more specific contigs than unassembled sequence data. | A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.
IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particularly if... |
scifact-qrel-4347374 | Generate text that supports or refutes this claim: Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome. | Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Viral replication usually requires that innate intracellular lines of defence be overcome, a task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) protein of human immunodefic... |
scifact-qrel-2014909 | Generate text that supports or refutes this claim: Deleting Raptor reduces G-CSF levels. | Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation
Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms gove... |
scifact-qrel-17997584 | Generate text that supports or refutes this claim: Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype. | Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during... |
scifact-qrel-23349986 | Generate text that supports or refutes this claim: Dexamethasone decreases risk of postoperative bleeding. | Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.
CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric tonsillectomy. OBJECTIVE To assess whether dexamethasone dose-dependently reduces the risk o... |
scifact-qrel-7873737 | Generate text that supports or refutes this claim: Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. | Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.
BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this disease may be associated with increased platelet aggregatio... |
scifact-qrel-5884524 | Generate text that supports or refutes this claim: Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. | Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit,... |
scifact-qrel-16927286 | Generate text that supports or refutes this claim: Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3. | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation
In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cryo... |
scifact-qrel-8774475 | Generate text that supports or refutes this claim: Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis. | Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma
Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood.... |
scifact-qrel-38587347 | Generate text that supports or refutes this claim: During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells. | Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.
Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high-affin... |
scifact-qrel-19005293 | Generate text that supports or refutes this claim: Enhanced early production of inflammatory chemokines improves viral control in the lung. | Memory CD4+ T cells induce innate responses independently of pathogen
Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. We... |
scifact-qrel-13770184 | Generate text that supports or refutes this claim: Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings. | Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an... |
scifact-qrel-9955779 | Generate text that supports or refutes this claim: Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. | Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune therapy. Herein, pharmacologic and isoform specificity of HDACi... |
scifact-qrel-9767444 | Generate text that supports or refutes this claim: Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. | Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.
Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an immune suppre... |
scifact-qrel-16495649 | Generate text that supports or refutes this claim: Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations. | Ethnographic study of incidence and severity of intravenous drug errors.
OBJECTIVES To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur. DESIGN Prospective ethnographic study using disguised observati... |
scifact-qrel-1148122 | Generate text that supports or refutes this claim: Ethanol stress decreases the expression of IBP in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli
Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, a... |
scifact-qrel-791050 | Generate text that supports or refutes this claim: Exposure to fine particulate air pollution is relate to anxiety prevalence. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study
OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. DESIGN Observational cohort study. SETTING Nurses' Health Study. ... |
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