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scifact-corpus-31715818 | null | New opportunities: the use of nanotechnologies to manipulate and track stem cells.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, c... |
scifact-queries-1 | null | 0-dimensional biomaterials show inductive properties. |
scifact-corpus-14717500 | null | Rare Variants Create Synthetic Genome-Wide Associations
Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been convincingly replicated. It is generally thought... |
scifact-queries-3 | null | 1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. |
scifact-corpus-13734012 | null | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey
OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the... |
scifact-queries-5 | null | 1/2000 in UK have abnormal PrP positivity. |
scifact-corpus-1606628 | null | Estimates of global prevalence of childhood underweight in 1990 and 2015.
CONTEXT One key target of the United Nations Millennium Development goals is to reduce the prevalence of underweight among children younger than 5 years by half between 1990 and 2015. OBJECTIVE To estimate trends in childhood underweight by geogr... |
scifact-queries-13 | null | 5% of perinatal mortality is due to low birth weight. |
scifact-corpus-5152028 | null | Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact t... |
scifact-queries-36 | null | A deficiency of vitamin B12 increases blood levels of homocysteine. |
scifact-corpus-11705328 | null | Randomized trial of folic acid supplementation and serum homocysteine levels.
BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevant... |
scifact-queries-36 | null | A deficiency of vitamin B12 increases blood levels of homocysteine. |
scifact-corpus-18174210 | null | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia
BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for ... |
scifact-queries-42 | null | A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. |
scifact-corpus-13734012 | null | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey
OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the... |
scifact-queries-48 | null | A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. |
scifact-corpus-5953485 | null | ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechan... |
scifact-queries-49 | null | ADAR1 binds to Dicer to cleave pre-miRNA. |
scifact-corpus-12580014 | null | Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia. We report that autoimmune regulator (Ai... |
scifact-queries-50 | null | AIRE is expressed in some skin tumors. |
scifact-corpus-45638119 | null | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo exper... |
scifact-queries-51 | null | ALDH1 expression is associated with better breast cancer outcomes. |
scifact-corpus-45638119 | null | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo exper... |
scifact-queries-53 | null | ALDH1 expression is associated with poorer prognosis in breast cancer. |
scifact-corpus-49556906 | null | Metformin reverses established lung fibrosis in a bleomycin model
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2-4. AMPK is a critical sensor of... |
scifact-queries-54 | null | AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. |
scifact-corpus-4709641 | null | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using huma... |
scifact-queries-56 | null | APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. |
scifact-corpus-4709641 | null | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using huma... |
scifact-queries-57 | null | APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. |
scifact-corpus-5956380 | null | Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem glioma... |
scifact-queries-70 | null | Activation of PPM1D suppresses p53 function. |
scifact-corpus-4414547 | null | Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and rep... |
scifact-queries-70 | null | Activation of PPM1D suppresses p53 function. |
scifact-corpus-6076903 | null | Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field
Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We discovered that quadruple knockdown of ADMP and BMP2/4/7... |
scifact-queries-72 | null | Activator-inhibitor pairs are provided dorsally by Admpchordin. |
scifact-corpus-4387784 | null | Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essentia... |
scifact-queries-75 | null | Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. |
scifact-corpus-1215116 | null | “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reduction... |
scifact-queries-94 | null | Albendazole is used to treat lymphatic filariasis. |
scifact-corpus-18810195 | null | Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic ... |
scifact-queries-99 | null | Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. |
scifact-corpus-4381486 | null | Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing divisions so that older (‘immortal’) DNA strands are retained in daughter stem cells whereas newly synthesized strands segregate to differentiating ce... |
scifact-queries-100 | null | All hematopoietic stem cells segregate their chromosomes randomly. |
scifact-corpus-6157837 | null | Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.
Angiotensin converting enzyme (ACE) inhibitors are now one of the... |
scifact-queries-113 | null | Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. |
scifact-corpus-33872649 | null | Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capi... |
scifact-queries-115 | null | Anthrax spores can be disposed of easily after they are dispersed. |
scifact-corpus-6372244 | null | Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Antibiotics can have significant and long-lasting effects on the gastrointestinal tract microbiota, reducing colonization resistance against pathogens including Clostridium difficile. Here we ... |
scifact-queries-118 | null | Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile |
scifact-corpus-4883040 | null | Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis
BACKGROUND Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estima... |
scifact-queries-124 | null | Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. |
scifact-corpus-21598000 | null | Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.
Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by forming a plus-end complex at microtubule growing ends with ill-de... |
scifact-queries-127 | null | Arginine 90 in p150n is important for interaction with EB1. |
scifact-corpus-8290953 | null | Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.
BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the damaged ti... |
scifact-queries-128 | null | Arterioles have a larger lumen diameter than venules. |
scifact-corpus-27768226 | null | Open Access Increases Citation Rate
PLoS Biology publishes today a research article by Gunther Eysenbach that is not about biology. It is about citations. It provides robust evidence that open-access articles (OA articles) are more immediately recognized and cited than non-OA articles. As such, it adds objective suppor... |
scifact-queries-129 | null | Articles published in open access format are less likely to be cited than traditional journals. |
scifact-corpus-27768226 | null | Open Access Increases Citation Rate
PLoS Biology publishes today a research article by Gunther Eysenbach that is not about biology. It is about citations. It provides robust evidence that open-access articles (OA articles) are more immediately recognized and cited than non-OA articles. As such, it adds objective suppor... |
scifact-queries-130 | null | Articles published in open access format are more likely to be cited than traditional journals. |
scifact-corpus-7975937 | null | Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity remain incompletely understood. Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their producti... |
scifact-queries-132 | null | Aspirin inhibits the production of PGE2. |
scifact-corpus-38485364 | null | The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.
Tks5/Fish is a scaffolding protein with five SH3 domains and one PX domain. In Src-transformed cells, Tks5/Fish localizes to podosomes, discrete protrusions of the ventral membrane. We ge... |
scifact-queries-133 | null | Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. |
scifact-corpus-6969753 | null | Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.
Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membra... |
scifact-queries-133 | null | Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. |
scifact-corpus-17934082 | null | Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis
Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes are structures functionally similar to invadopodia that are found in oncogene-transformed fibroblasts and monocyte-d... |
scifact-queries-133 | null | Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. |
scifact-corpus-16280642 | null | Sequential signals toward podosome formation in NIH-src cells
Podosomes (also termed invadopodia in cancer cells) are actin-rich adhesion structures with matrix degradation activity that develop in various cell types. Despite their significant physiological importance, the molecular mechanism of podosome formation is l... |
scifact-queries-133 | null | Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. |
scifact-corpus-12640810 | null | Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodi... |
scifact-queries-133 | null | Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. |
scifact-corpus-26016929 | null | Effectiveness of screening older people for impaired vision in community setting: systematic review of evidence from randomised controlled trials.
OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of randomi... |
scifact-queries-137 | null | Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. |
scifact-corpus-6955746 | null | Auditory Cortex Tracks Both Auditory and Visual Stimulus Dynamics Using Low-Frequency Neuronal Phase Modulation
Integrating information across sensory domains to construct a unified representation of multi-sensory signals is a fundamental characteristic of perception in ecological contexts. One provocative hypothesis d... |
scifact-queries-141 | null | Auditory entrainment is strengthened when people see congruent visual and auditory information. |
scifact-corpus-14437255 | null | Congruent Visual Speech Enhances Cortical Entrainment to Continuous Auditory Speech in Noise-Free Conditions.
UNLABELLED Congruent audiovisual speech enhances our ability to comprehend a speaker, even in noise-free conditions. When incongruent auditory and visual information is presented concurrently, it can hinder a l... |
scifact-queries-141 | null | Auditory entrainment is strengthened when people see congruent visual and auditory information. |
scifact-corpus-10582939 | null | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-queries-142 | null | Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. |
scifact-corpus-10582939 | null | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-queries-143 | null | Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. |
scifact-corpus-10582939 | null | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain chal... |
scifact-queries-146 | null | Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. |
scifact-corpus-1084345 | null | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We h... |
scifact-queries-148 | null | Autophagy declines in aged organisms. |
scifact-corpus-18872233 | null | Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.
IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surgery; ho... |
scifact-queries-163 | null | Bariatric surgery has a positive impact on mental health. |
scifact-corpus-12670680 | null | BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their h... |
scifact-queries-171 | null | Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). |
scifact-corpus-16322674 | null | Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies
BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant da... |
scifact-queries-179 | null | Birth-weight is positively associated with breast cancer. |
scifact-corpus-27123743 | null | Role of birthweight in the etiology of breast cancer.
Breast cancer may originate in utero. We reviewed the available evidence on the association between birthweight and the risk of breast cancer. To date, 26 research papers addressing this issue have been published. The majority of studies identified a positive link b... |
scifact-queries-179 | null | Birth-weight is positively associated with breast cancer. |
scifact-corpus-23557241 | null | Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.
BACKGROUND Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of maternal... |
scifact-queries-179 | null | Birth-weight is positively associated with breast cancer. |
scifact-corpus-17450673 | null | Intrauterine environments and breast cancer risk: meta-analysis and systematic review
INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal env... |
scifact-queries-179 | null | Birth-weight is positively associated with breast cancer. |
scifact-corpus-16966326 | null | The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity
Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological featu... |
scifact-queries-180 | null | Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. |
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