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Title: Purification and composition of Ca2+/Mg2+ ATPase from rat heart plasma membrane Abstract: The Ca2+/Mg2+ ATPase, which is activated by millimolar concentrations of Ca2+ or Mg2+, was solubilized from rat heart plasma membrane by employing lysophosphatidylcholine, CHAPS, NaI, EDTA and Tris-HCl at pH 7.4. The enzyme...
13,015
Title: Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover Abstract: The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and other phenotypes relevant to pathogenesis. Cyclic-di-GMP is synthesized by diguanylat...
13,036
Title: Developing a therapeutic relationship with a blind client with a severe intellectual disability and persistent challenging behaviour Abstract: Purpose. A blind, severely intellectually impaired boy aged 17 with Down syndrome and persistent serious challenging behavior received attachment-based behavior modificat...
13,099
Title: hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas Abstract: The c-Met receptor tyrosine kinase (MetR) is frequently overexpressed and constitutively phosphorylated in a number of human malignancies. Activation of the receptor by its ligand, hepatocyte growth factor (HGF), lead...
13,156
Title: Does habitat availability determine geographical-scale abundances of coral-dwelling fishes? Abstract: The role of local-scale processes in determining large-scale patterns of abundance is a key issue in ecology. To test whether habitat use determines local and large-scale patterns of abundance of obligate coral-...
13,173
Title: Efficient Non-Viral Ocular Gene Transfer with Compacted DNA Nanoparticles Abstract: Background ::: The eye is an excellent candidate for gene therapy as it is immune privileged and much of the disease-causing genetics are well understood. Towards this goal, we evaluated the efficiency of compacted DNA nanopartic...
13,236
Title: Renal Production, Uptake, and Handling of Circulating Klotho Abstract: αKlotho is a multifunctional protein highly expressed in the kidney. Soluble αKlotho is released through cleavage of the extracellular domain from membrane αKlotho by secretases to function as an endocrine/paracrine substance. The role of the...
13,238
Title: Pharmacodynamics of vancomycin in elderly patients aged 75 years or older with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia Abstract: BACKGROUND ::: Methicillin-resistant Staphylococcus aureus (MRSA) infections are associated with significant mortality and health care costs. To improve...
13,239
Title: Transjugular intrahepatic portosystemic shunt in an infant Abstract: A 15-month-old girl, who presented with biliary cirrhosis secondary to cystic fibrosis with refractory ascites and recurrent intestinal bleeding, underwent percutaneous transjugular intrahepatic portosystemic shunting. Immediately following the...
13,243
Title: Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep Abstract: BACKGROUND ::: Preterm infants often receive mechanical ventilation and oxygen at birth. Exposure to large tidal volumes (V(T)s) at birth causes lung inflammation, and oxygen may amplify the injury. We hy...
13,275
Title: Impact of sleep‐related symptoms on clinical motor subtypes and disability in Parkinson's disease: a multicentre cross‐sectional study Abstract: Objectives To investigate the impact of sleep disturbances on Parkinson’s disease (PD) clinical motor subtypes and disease-related disability in a multicentre setting. ...
13,299
Title: Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae Abstract: The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae. In an acidification assay, polygodial completely suppressed the glucose-induced decrease in ...
13,307
Title: Using a model-based framework for analysing genetic diversity during germination and heterotrophic growth of Medicago truncatula Abstract: BACKGROUND AND AIMS ::: The framework provided by an emergence model was used: (1) for phenotyping germination and heterotrophic growth of Medicago truncatula in relation to ...
13,529
Title: Pain Relief as a Primary Treatment Goal: at What Point does Functioning and Well-Being Become more Important? a Case Study of an Adolescent with Debilitating Chronic Pain Abstract: BACKGROUND: Pediatric chronic pain is a common problem with significant economic implications and devastating consequences on qualit...
13,549
Title: Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation Abstract: Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the...
13,560
Title: Faster and More Accurate Sequence Alignment with SNAP Abstract: We present the Scalable Nucleotide Alignment Program (SNAP), a new short and long read aligner that is both more accurate (i.e., aligns more reads with fewer errors) and 10-100x faster than state-of-the-art tools such as BWA. Unlike recent aligners ...
13,601
Title: Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis Abstract: Previous studies have shown that retinoids and rexinoids can prevent breast cancer in animal models and in women with increased risk of developing the disease. The cellular effects of these vitamin A analogues have...
13,623
Title: Selective inhibition of mesophyll chloroplast development in some C4-pathway species by low night temperature Abstract: SummaryExposure of plants of Sorghum bicolor L. line E 1287 and hybrid NK 145, of Digitaria smutsii Stapf, and of Paspalum dilatatum L.-grasses having the C4 pathway of photosynthesis-to temper...
13,634
Title: Ranibizumab: A Review of its Use in Myopic Choroidal Neovascularization Abstract: Ranibizumab (Lucentis®) is the first inhibitor of vascular endothelial growth factor (VEGF)-A licensed for the treatment of visual impairment due to choroidal neovascularization (CNV) secondary to pathologic myopia (i.e. myopic CNV...
13,635
Title: Cytogenetic studies on wild house mice from Belgium Abstract: The present status of Robertsonian karyotype variation in populations of wild mice from Belgium is presented. Two fusions, Rb(4.12)1Nam and Rb(5.10)3Nam, were identified in the central plain of this flat country. Surrounding this region only mice with...
13,673
Title: Isolation and characterization of seventy-nine full-length mariner-like transposase genes in the Bambusoideae subfamily Abstract: Mariner-like elements (MLEs) are the most diverse and widespread transposable elements, with members of the MLE superfamily found in fungi, plants, ciliates and animals. In a previous...
13,703
Title: Six-Month Angiographic Outcome After Successful Repeat Percutaneous Intervention for In-Stent Restenosis Abstract: Background—In-stent restenosis is an increasing clinical problem. Discordant results have been published regarding the risk of recurrent restenosis after repeat angioplasty for the treatment of in-s...
13,798
Title: Cancer surveillance in ulcerative colitis and Crohn's disease: new strategies. Abstract: PURPOSE OF REVIEW ::: Inflammatory bowel disease (IBD) patients have a higher incidence of colon cancer than the general population. Colon cancer surveillance has traditionally involved taking numerous random biopsies to pro...
13,832
Title: Quantitative genomics of locomotor behavior in Drosophila melanogaster Abstract: BackgroundLocomotion is an integral component of most animal behaviors, and many human health problems are associated with locomotor deficits. Locomotor behavior is a complex trait, with population variation attributable to many int...
13,871
Title: Bacterial, Archaeal, and Eukaryotic Diversity across Distinct Microhabitats in an Acid Mine Drainage Abstract: Acid mine drainages are characterized by their low pH and the presence of dissolved toxic metallic species. Microorganisms survive in different microhabitats within the ecosystem, namely water, sediment...
13,904
Title: Self-reported sitting time is not associated with incidence of cardiovascular disease in a population-based cohort of mid-aged women Abstract: In Westernised societies adults are increasingly spending many hours each day in sedentary, low energy expenditure activities such as sitting. Although there is growing e...
13,947
Title: Dynamics of phosphodiester synthesis by DNA ligase Abstract: Ligases are essential actors in DNA replication, recombination, and repair by virtue of their ability to seal breaks in the phosphodiester backbone. Ligation proceeds through a nicked DNA-adenylate intermediate (AppDNA), which must be sealed quickly to...
13,968
Title: Neuroendocrine Control of Body Fluid Metabolism Abstract: Mammals control the volume and osmolality of their body fluids from stimuli that arise from both the intracellular and extracellular fluid compartments. These stimuli are sensed by two kinds of receptors: osmoreceptor-Na+ receptors and volume or pressure ...
14,046
Title: Biofeedback-based cognitive-behavioral treatment compared with occlusal splint for temporomandibular disorder: a randomized controlled trial. Abstract: OBJECTIVES ::: Cognitive-behavioral treatment has proven efficacy for chronic temporomandibular disorder (TMD). However, most patients receive dental treatment t...
14,147
Title: Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase. Abstract: Activating mutations of Ras have been implicated in approximately 30% of human cancers. In every case, the biochemical consequence of such mutations is to disrupt the GTPase activity of Ras and to render Ras r...
14,152
Title: Overexpression of Tissue Inhibitor of Metalloproteinases-3 in Intestinal and Cutaneous Lesions of Graft-versus-Host Disease Abstract: Matrix metalloproteinases (MMPs) have been implicated in the pathobiology of various T-cell-mediated inflammatory disorders of the intestine and skin. Their synthetic inhibitor ha...
14,265
Title: The Application of Transformational Leadership Theory to Parenting: Questionnaire Development and Implications for Adolescent Self- Regulatory Efficacy and Life Satisfaction Abstract: We draw upon transformational leadership theory to develop an instrument to measure transformational parenting for use with adole...
14,279
Title: A Proteomic Approach for Plasma Biomarker Discovery with iTRAQ Labelling and OFFGEL Fractionation Abstract: Human blood plasma contains a plethora of proteins, encompassing not only proteins that have plasma-based functionalities, but also possibly every other form of low concentrated human proteins. As it circu...
14,306
Title: Endothelial lipase genetic polymorphisms and the lipid-lowering response in patients with coronary artery disease on rosuvastatin Abstract: BACKGROUND ::: Endothelial lipase (EL) plays an important role in the regulation of lipid metabolism by reducing the high density lipoprotein cholesterol (HDL-C) levels and ...
14,326
Title: Decoding of MSTd Population Activity Accounts for Variations in the Precision of Heading Perception Abstract: Humans and monkeys use both vestibular and visual motion (optic flow) cues to discriminate their direction of self-motion during navigation. A striking property of heading perception from optic flow is t...
14,401
Title: Genetic cryptic species as biological invaders: the case of a Lessepsian fish migrant, the hardyhead silverside Atherinomorus lacunosus Abstract: Marine cryptic species, taxa that are morphologically identical but genetically distinct, may be important and underestimated components of the ecosystem. The understa...
14,486
Title: Posterior Dynamic Stabilization as a Salvage Procedure for Lumbar Facet Degeneration Following Total Disc Arthroplasty: Case report Abstract: Following an L5–S1 SB Charite disc III implantation, a 37-year-old female patient developed intractable radicular pain in the left L5 distribution. The patient underwent a...
14,527
Title: Is sleep education an effective tool for sleep improvement and minimizing metabolic disturbance and obesity in adolescents? Abstract: The prevalence of childhood obesity has increased significantly in recent years. Obesity is associated with a range of adverse physiological, psychological and social outcomes and...
14,582
Title: Genomic Analysis of the BMP Family in Glioblastomas Abstract: Glioblastoma multiforme (GBM) is a grade IV glioma with a median survival of 15 months. Recently, bone morphogenetic protein (BMP) signaling has been shown to promote survival in xenograft murine models. To gain a better understanding of the role of B...
14,712
Title: Characteristics of CDC group 3 and group 5 coryneform bacteria isolated from clinical specimens and assignment to the genus Dermabacter. Abstract: Over a 1-year period, 11 isolates (including 5 from blood cultures) of the recently described CDC group 3 and group 5 coryneform bacteria were derived from clinical s...
14,719
Title: Metastatic disease from uveal melanoma: treatment options and future prospects Abstract: Uveal melanoma represents ∼85% of all ocular melanomas and up to 50% of patients develop metastatic disease. Metastases are most frequently localised to the liver and, as few patients are candidates for potentially curative ...
14,752
Title: A comparison of surveillance systems for the dengue vector Aedes aegypti in port of Spain, Trinidad Abstract: When the currently used larval surveillance system (visual inspection) for the dengue vector Aedes aegypti was compared with the surveillance for the presence of eggs by ovitrapping in Port of Spain, Tri...
14,804
Title: How Do Risk Factors Work Together? Mediators, Moderators, and Independent, Overlapping, and Proxy Risk Factors Abstract: OBJECTIVE: The authors developed a methodological basis for investigating how risk factors work together. Better methods are needed for understanding the etiology of disorders, such as psychia...
14,868
Title: Association mapping and fine mapping with TreeLD Abstract: SUMMARY ::: The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeL...
14,894
Title: Social learning and evolution: the cultural intelligence hypothesis Abstract: If social learning is more efficient than independent individual exploration, animals should learn vital cultural skills exclusively, and routine skills faster, through social learning, provided they actually use social learning prefer...
14,907
Title: Functional redundancy and/or ongoing pseudogenization among F-box protein genes expressed in Arabidopsis male gametophyte Abstract: F-box protein genes family is one of the largest gene families in plants, with almost 700 predicted genes in the model plant Arabidopsis. F-box proteins are key components of the ub...
14,927
Title: Factors that May Affect Treatment Outcome of Triple Helicobacter pylori Eradication Therapy with Omeprazole, Amoxicillin, and Clarithromycin Abstract: Factors affecting Helicobacter pylori eradication rate with omeprazole (OME), clarithromycin (CL), and amoxicillin (AMO) have not been extensively studied. We hav...
14,942
Title: Combined effects of nifekalant and lidocaine on the spiral-type re-entry in a perfused 2-dimensional layer of rabbit ventricular myocardium. Abstract: BACKGROUND ::: Spiral re-entry plays the principal role in the genesis of ventricular tachycardia and ventricular fibrillation (VT/VF). The specific I(Kr) blocker...
14,968
Title: A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours Abstract: Antibody-directed enzyme prodrug therapy is a targeted therapy in which a prodrug is activated selectively at the tumour site by an enzyme, which has been ta...
15,042
Title: Helminth infections in small mammals from Ulu Gombak Forest Reserve and the risk to human health. Abstract: A survey for small mammal parasites carried out in a secondary forest of Ulu Gombak, Selangor, Peninsula Malaysia yielded the following animals: Rattus bowersi (7), Rattus tiomanicus jalorensis (2), Maxomy...
15,075
Title: The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve Abstract: This study aimed to evaluate the effects of low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve with two surgical techniques: e...
15,085
Title: Heterosynaptic Plasticity Underlies Aversive Olfactory Learning in Drosophila Abstract: Summary Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term...
15,225
Title: The efficacy and safety of crizotinib in the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer: a meta-analysis of clinical trials Abstract: BackgroundCrizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase ...
15,228
Title: Early Experience With (Dry) Arthroscopic 4-Corner Arthrodesis: From a 4-Hour Operation to a Tourniquet Time Abstract: Purpose Scaphoidectomy and 4-corner arthrodesis (4CA) is an effective procedure for treating several degenerative conditions of the wrist. Recently, the arthroscopic approach to this operation wa...
15,240
Title: Carinal resection and reconstruction for recurrent lung cancer Abstract: A patient with a recurrent tumor in the trachea adjacent to the right main bronchus was treated by surgical resection 19 months after undergoing surgery for the primary cancer. The patient had previously undergone right upper lobectomy for ...
15,477
Title: Unfattening our children: forks over feet Abstract: Childhood obesity rates have risen alarmingly for decades, and although recent data suggest a possible plateau, obesity is seen in ever younger children, and is increasingly severe. The proximal cause of obesity is energy imbalance; the root cause is modern liv...
15,486
Title: Molecular characterization and phylogenetic utility of the rDNA external transcribed spacer region in Stylosanthes (Fabaceae) Abstract: Supplementary Material The nucleotide sequence of the ribosomal external transcribed spacer (ETS) region of Stylosanthes mexicana was determined and used to evaluate its potenti...
15,645
Title: Barriers and facilitators to the use of computer-based intensive insulin therapy Abstract: Abstract Purpose Computerized clinical decision support systems (CDSSs) for intensive insulin therapy (IIT) are increasingly common. However, recent studies question IIT's safety and mortality benefit. Researchers have ide...
15,738
Title: Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)” Abstract: Human sirtuins are seven proteins with deacetylase activity that are emerging as key modulators of basic physiological functions. Some evidence links SIRT3 to longevity in mammals...
15,762
Title: Inducible nitric oxide synthase and cytokine pattern in lesions of patients with American cutaneous leishmaniasis. Abstract: American tegumentary leishmaniasis has three forms: localized (LCL), found in resistant individuals; diffuse (DCL), found in susceptible individuals; and intermediate cutaneous leishmanias...
15,830
Title: Secondary product glycosyltransferases in seeds of Brassica napus Abstract: This study describes a systematic screen for secondary product UDP-glycosyltransferases (UGTs; EC 2.4.1) involved in seed development of oilseed rape (Brassica napus) and was aimed at identifying genes related to UGT84A9 encoding UDP-glu...
15,845
Title: Serum Immunoglobulin G Antibodies to Chlamydial Heat Shock Protein 60 but Not to Human and Bacterial Homologs Are Associated With Coronary Artery Disease Abstract: BACKGROUND ::: Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous stu...
16,104
Title: Effect of Formulation- and Administration-Related Variables on Deposition Pattern of Nasal Spray Pumps Evaluated Using a Nasal Cast Abstract: PURPOSE ::: To systematically evaluate the effect of formulation- and administration-related variables on nasal spray deposition using a nasal cast. ::: ::: ::: METHODS ::...
16,150
Title: Diffusion with Stochastic Resetting Abstract: We study simple diffusion where a particle stochastically resets to its initial position at a constant rate r. A finite resetting rate leads to a nonequilibrium stationary state with non-Gaussian fluctuations for the particle position. We also show that the mean time...
16,259
Title: A soybean 101-kD heat shock protein complements a yeast HSP104 deletion mutant in acquiring thermotolerance. Plant Cell 6 Abstract: A cDNA clone encoding a 101-kD heat shock protein (HSP101) of soybean was isolated and sequenced. Genomic DNA gel blot analysis indicated that the corresponding gene is a member of ...
16,268
Title: Child Abuse and Orthopaedic Injury Patterns: Analysis at a Level I Pediatric Trauma Center Abstract: BACKGROUND: Child abuse is a serious threat to the physical and psychosocial well-being of the pediatric population. Musculoskeletal injuries are common manifestations of child abuse. There have been multiple stu...
16,326
Title: Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor Abstract: TLR3 belongs to the family of intracellular TLRs that recognize nucleic acids. Endolysosomal localization and cleavage of intracellular TLRs play pivotal roles in signaling and represent fail-safe mechanisms to prevent self-n...
16,345
Title: Thrombosis after kidney transplantation. Abstract: The diagnosis of deep vein thrombosis (DVT) is unusual in patients with sickle cell disease (SCD). Despite the incidence of cerebral thrombosis in SCD patients due to vasooclusion, thrombotic manifestations in peripheral vessels are rare. Patients with homozygou...
16,389
Title: Attributing Effects to Interactions Abstract: A framework is presented that allows an investigator to estimate the portion of the effect of one exposure that is attributable to an interaction with a second exposure. We show that when the 2 exposures are statistically independent in distribution, the total effect...
16,469
Title: Spectral and Spatial-Based Classification for Broad-Scale Land Cover Mapping Based on Logistic Regression Abstract: Improvement of satellite sensor characteristics motivates the development of new techniques for satellite image classification. Spatial information seems to be critical in classification processes,...
16,485
Title: MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine Abstract: Abstract The human MDR1 P-glycoprotein (Pgp) extrudes a variety of drugs across the plasma membrane. The homologous MDR3 Pgp is required for phosphatidylcholine secre...
16,488
Title: Consistent avoidance of human disturbance over large geographical distances by a migratory bird Abstract: Recent work on animal personalities has demonstrated that individuals may show consistent behaviour across situations and contexts. These studies were often carried out in one location and/or during short ti...
16,520
Title: Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia Abstract: Methionine adenosyltransferase (MAT) I/III deficiency is an inborn error of metabolism caused by mutations in MAT1A, encoding the catalytic subunit of MAT responsible for the synthesis of S-adenosylmethionine, and...
16,540
Title: Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum Abstract: Xingnaojing (XNJ), is a standardized Chinese herbal medicine product derived from An Gong Niu Huang Pill. It may be involved in neuroprotection in a number of neurological disorders. E...
16,582
Title: Estrogenic Potency of Benzophenone UV Filters in Breast Cancer Cells: Proliferative and Transcriptional Activity Substantiated by Docking Analysis Abstract: The results from recent studies show that some benzophenones (BPs) and their hydroxylated metabolites can function as weak estrogens (E2) in the environment...
16,604
Title: Distinct Expression Pattern of Microtubule-Associated Protein-2 in Human Oligodendrogliomas and Glial Precursor Cells Abstract: Microtubule-associated protein 2 (MAP2), a protein linked to the neuronal cytoskeleton in the mature central nervous system (CNS), has recently been identified in glial precursors indic...
16,613
Title: Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis Abstract: A prospective randomized double-blind trial comparing the butyrophenone analogue domperidone (D) and the synthetic cannabinoid nabilone (N) in the treatment of cytotoxic-induced emesis ...
16,616
Title: Excess gains in weight and waist circumference associated with childbearing: The Coronary Artery Risk Development in Young Adults Study (CARDIA) Abstract: OBJECTIVE ::: To examine the association of childbearing with weight and waist circumference (WC) changes, we compared women with and without pregnancies or b...
16,689
Title: Botulinum toxin therapy of cervical dystonia: duration of therapeutic effects Abstract: We sought to explore the therapeutic effect of botulinum toxin (BT) therapy by analysing the time between the BT application and the onset of its decrease (treatment duration, TD), the inter-injection interval (II), and the e...
16,721
Title: An analysis of ophthalmology trainees’ perceptions of feedback for cataract surgery training Abstract: Objectives ::: To determine whether feedback for cataract surgery is perceived to be given to trainee ophthalmologists, the way in which any feedback is given, and what the trainee perceives to be the effect of...
16,805
Title: First reported revascularization of complex occlusion of the right coronary artery using the IVUS-guided reverse CART technique via a gastroepiploic artery graft Abstract: When patients who have previously undergone coronary artery bypass graft surgery develop ischemia symptoms that cannot be controlled by optim...
16,823
Title: Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth Abstract: Purpose: To determine whether -CONH-(CH 2 ) 6 -NH 3 + Cl − functionalized single-walled carbon nanotubes (SWNT) carrying complexed small interferi...
16,898
Title: Recovery of vocal fold paralysis after cardiovascular surgery Abstract: Objectives/Hypothesis: To review the incidence and time course of recovery of vocal fold paralysis (VFP) in adult patients after cardiovascular surgery. Study Design: Retrospective cohort study of adults after cardiovascular surgery at a ter...
17,014
Title: Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride, or haloperidol Abstract: Background Atypical antipsychotic drugs, in clinical doses, occupy 5-HT2 receptors near saturation, while D2 dopamine recepto...
17,039
Title: Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei Abstract: We have used double in situ hybridization to examine the cellular localization of 5-HT2C receptor mRNA in relation to serotonergic and GABAergic neurons in the anterior raphe nuclei of the rat. In the dorsal and me...
17,082
Title: Enhanced recognition of protein transmembrane domains with prediction-based structural profiles Abstract: Motivation: Membrane domain prediction has recently been re-evaluated by several groups, suggesting that the accuracy of existing methods is still rather limited. In this work, we revisit this problem and pr...
17,089
Title: Continuous Stroke Unit Electrocardiographic Monitoring Versus 24-Hour Holter Electrocardiography for Detection of Paroxysmal Atrial Fibrillation After Stroke Abstract: BACKGROUND AND PURPOSE ::: Cardioembolism in paroxysmal atrial fibrillation (pxAF) is a frequent cause of ischemic stroke. Sensitive detection of...
17,100
Title: Three-dimensional reconstruction of the antennal lobe inDrosophila melanogaster Abstract: We present the first three-dimensional map of the antennal lobe of Drosophila melanogaster, based on confocal microscopic analysis of glomeruli stained with the neuropil-specific monoclonal antibody nc82. The analysis of co...
17,106
Title: Indoor concentrations of nicotine in low-income, multi-unit housing: associations with smoking behaviours and housing characteristics Abstract: Objective: An analysis of airborne nicotine measurements collected in 49 low-income, multi-unit residences across the Greater Boston Area. Methods: Nicotine concentratio...
17,107
Title: Exploring the Role of Cognitive Reserve in Early-Onset Dementia Abstract: Aim: Cognitive reserve (CR) is important in protecting the brain from injury and has not been investigated in people with early-onset dementia (EOD). Methods: A retrospective case control study of 44 patients with dementia onset prior to 6...
17,258
Title: BAC library resources for map-based cloning and physical map construction in barley (Hordeum vulgare L.) Abstract: BackgroundAlthough second generation sequencing (2GS) technologies allow re-sequencing of previously gold-standard-sequenced genomes, whole genome shotgun sequencing and de novo assembly of large an...
17,292
Title: Mapping of mutations affecting synthesis of exocellular enzymes in Bacillus subtilis Abstract: The sacUh, amyB and pap mutations are identical with respect to their pleiotropic phenotype and their genetic location. Strains bearing these mutations overproduce several exocellular enzymes: alpha amylase, lavansucra...
17,393
Title: The Plights of African Resources Patenting through the Lenses of the World Trade Organisation: An Assessment of South Africa’s Rooibos Tea’s Labyrith Journey Abstract: BACKGROUND ::: Just as developing states are blessed with natural resources capable of transforming their economies into a positive direction, th...
17,454
Title: Optimising the analysis of transcript data using high density oligonucleotide arrays and genomic DNA-based probe selection Abstract: BackgroundAffymetrix GeneChip arrays are widely used for transcriptomic studies in a diverse range of species. Each gene is represented on a GeneChip array by a probe-set, consisti...
17,462
Title: Effect of Endotoxin on P-Glycoprotein-Mediated Biliary and Renal Excretion of Rhodamine-123 in Rats Abstract: The effects of Klebsiella pneumoniae endotoxin on the biliary excretion and renal handling of rhodamine-123 were investigated in rats at different times after intraperitoneal injection (1 mg/kg of body w...
17,802
Title: Polarisation Dynamics of Vector Soliton Molecules in Mode Locked Fibre Laser Abstract: Two fundamental laser physics phenomena - dissipative soliton and polarisation of light are recently merged to the concept of vector dissipative soliton (VDS), viz. train of short pulses with specific state of polarisation (SO...
17,905
Title: Heat shock proteins – modulators of apoptosis in tumour cells Abstract: Apoptosis is a genetically programmed, physiological method of cell destruction. A variety of genes are now recognised as positive or negative regulators of this process. Expression of inducible heat shock proteins (hsp) is known to correlat...
17,914
Title: Sparsey™: event recognition via deep hierarchical sparse distributed codes Abstract: The visual cortex’s hierarchical, multi-level organization is captured in many biologically inspired computational vision models, the general idea being that progressively larger scale (spatially/temporally) and more complex vis...
17,997
Title: The anomalous Kentucky coffeetree: megafaunal fruit sinking to extinction? Abstract: The Kentucky coffeetree (Gymnocladus dioicus, Fabaceae) is an ecological paradox. A rare tree in nature in eastern and central North America, G. dioicus produces legumes that are only known to be dispersed by water, but appear s...
18,015
Title: Matrix metalloproteinases in type 2 diabetes and non-diabetic controls: effects of short-term and chronic hyperglycaemia Abstract: Introduction ::: The role of matrix metalloproteinases (MMPs) in type 2 diabetes mellitus (DM) is not clear as increased activation of MMPs in the vasculature contrasts with decrease...
18,063