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<context> Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. T...
<context> However, in general, HMTs have no widely accepted high-throughput screening (HTS) assay format, and reference inhibitors are not available for many of the enzymes. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. ...
<context> We found a very significant increase in average longevity (17%) of the cyclists when compared with the general population. The age at which 50% of the general population died was 73.5 vs. 81.5 years in Tour de France participants. Our major finding is that repeated very intense exercise prolongs life span i...
<context> Molecular tests such as the 21 gene expression test (Oncotype DX(TM)) and 70 gene microarray test (MammaPrint(®)) have revolutionized the predictive and prognostic tools in the clinic. By stratifying the risk of recurrence for patients, the tests are able to provide clinicians with more information on the t...
<context> Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel. MammaPrint is the first FDA approved, gene expression-based prognostic test which assess patients’ risk for distant me...
<context> Survivin (BIRC5) is one of the members of IAP-family apoptosis inhibitors. The BIRCS gene is expressed in most human embryonic tissues and malignant tumors but not in normal differentiated tissues of adult human. Survivin is an inhibitor of apoptosis that is undetectable in most terminally differentiated no...
<context> Malfunction of the circadian clock has been linked to the pathogenesis of a variety of diseases. We show that mice lacking the core clock components Cryptochrome-1 (Cry1) and Cryptochrome-2 (Cry2) (Cry-null mice) show salt-sensitive hypertension due to abnormally high synthesis of the mineralocorticoid aldo...
<context> The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Moreover, PLN-R14Del did not co-immunoprecipitate with SERCA2a (as did WT-PLN), n this review, we attempted to highlight the functional significance of PLN in vertebrate cardiac physiology. We will...
<context> UGT1A1*28/*28 genotype was associated with more than fourfold (odds ratio (OR)=4.79, 95% confidence intervals (CI): 3.28-7.01; P<0.00001) and threefold (OR=3.44, 95% CI: 2.45-4.82; P<0.00001) increases in the risk of neutropenia when compared with wild type and with at least one UGT1A1*1 allele, respectivel...
<context> Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor. The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancr...
<context> In diabetic vs. nondiabetic patients T(1)AM concentration was significantly increased (0.232 ± 0.014 vs. 0.203 ± 0.006 pmol/ml, P = 0.044), Our results are consistent with the hypothesis that circulating T(1)AM is produced from thyroid hormones and encourage further investigations on the potential role of T...
<context> The results indicate that mutations in TPM2 may cause nemaline myopathy as well as cap disease with a dominant mode of inheritance. Autosomal recessive inheritance had been verified or appeared likely in all nebulin cases Most cases were sporadic, but in addition there were instances of both autosomal domin...
<context> loss of Thra protects mice from high-fat diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. liganded TR(alpha) plays a critical role in beta-cell replication and in expansion of the beta-cell mass during postnatal development. Thus, liganded TR(alpha) may be a target for therapeut...
<context> These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms. The improved cardiac function was associated with decreased atrial natriuretic peptide mRNA levels in the metformin-treated group (50% reduction compared with MI, P < 0....
<context> We demonstrated that thyroid hormone T3 rapidly induces Akt activation in pancreatic beta cells rRINm5F and hCM via thyroid hormone receptor (TR) beta1. The silencing of TRbeta1 expression through RNAi confirmed this receptor to be crucial for the T3-induced activation of Akt. T3 is able to specifically act...
<context> our data suggests that TRbeta1-mediated down regulation of hepatic LDLr gene may play a critical role in iodine excess-induced hypercholesterolemic effects. These data suggest that ChREBP mRNA expression is positively regulated by TR-beta1 and TH at the transcriptional level in mammals. This novel observati...
<context> Mice expressing the mutant thyroid hormone receptor TRalpha1R384C, which has a 10-fold reduced affinity to the ligand T(3), exhibit hypermetabolism due to an overactivation of the sympathetic nervous system. To define the consequences in the liver, we analyzed hepatic metabolism and the regulation of liver ...
<context> e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a. On the other hand, T₃ treatment incre...
<context> The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load. Ethanolic extract of ...
<context> In the traditional model at least two different families of MTases were proposed to exist in eukaryotes: one family that is required for de novo methylation of DNA targeting un-methylated DNA, while the other family is specific for hemi-methylated DNA copying the methylation pattern in every replication cyc...
<context> Administration of debutyl-dronedarone (DBD), a TRα1 antagonist abolished the T3-limiting effect on reperfusion injury: Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50%. In the LVW, AM and Dron decreased TRbeta 1 Hypothyroid heart displays a phenotype...
<context> Amiodarone resulted in increased T4, T4/T3 and rT3, whereas dronedarone did not alter the thyroid hormone profile in normal animals. Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17). Thyroid fun...
<context> AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50% In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1. n the apex, AM also increased TRalpha 2. Both in treated and untreated mice, TRalpha2 mRNA had the highest ...
<context> treatment of the cells with T(3) for 2 d induced the expression of thyroid hormone receptor-beta and caspase-3, and this thyroid hormone receptor-beta induction was drastically repressed by xTNF-alpha. </context> <question> How does TNF affect thyroid hormone receptors? </question> <answer> TNF-alp...
<context> PE, in the absence of T3, resulted in 5.0 fold increase in TRalpha1 expression in nucleus and 2.0 fold decrease in TRalpha1 expression in cytosol, P<0.05. nuclear TRalpha1 is overexpressed after prolonged activation of the alpha1- adrenergic signalling by PE. This response seems to be an ERK kinase dependen...
<context> Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer Regions of focal hypermethylation in the tumor were located primarily at CpG islands and were concentrated within regions of long-range (>100 kb) hypomethylation. These hypomethylated domains covered nearly half of the...
<context> Etoposide is effective as an anti-tumour drug by inhibiting eukaryotic DNA topoisomerase II via establishing a covalent complex with DNA benzoxazoles, benzimidazoles and related fused heterocyclic compounds, which exhibited significant eukaryotic DNA topoisomerase II inhibitory activity F14512, a polyamine-...
<context> our study established a novel approach utilizing high-resolution SNP array to identify lincRNA candidates, which could functionally link to tumorigenesis lincRNAs have been increasingly acknowledged for their expressional dynamics and likely functional associations with cancers HOTAIR is a negative prognost...
<context> The Rubinstein-Taybi syndrome (RTS) is a well-defined syndrome with facial abnormalities, broad thumbs, broad big toes and mental retardation as the main clinical features Many patients with RTS have been shown to have breakpoints in, and microdeletions of, chromosome 16p13.3 these breakpoints are restricte...
<context> Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease To further explore the therapeutic potential of HDAC inhibitors, we have conducted preclinical trials with suberoylanilide hydroxamic acid (SAHA), a potent HDAC inhibitor, in...
<context> The peptide is bound in the conventional manner; i.e., the methyl-lysine is oriented on the opposite surface of SMYD3 from the SAM/Sinefungin methyl donor, with a narrow channel connecting the two surfaces of the SET domain. For radioactive based assays, 2 µCi S-adenosyl-L–[methyl-3H] methionine (SAM; Amers...
<context> For robustness evaluation, we apply bootstrap and jackknife techniques to input data. An alignment confidence score capturing robustness to guide tree uncertainty. We build on the widely used bootstrap method for perturbing the phylogenetic tree. SuperTRI: A new approach based on branch support analyses of ...
<context> We isolated human mononucleosomes bound by the bromodomain-containing proteins Brd2, Brd3 and Brd4, and by the chromodomain-containing heterochromatin proteins HP1 beta and HP1 alpha. Their hallmark is the presence of a chromodomain at the C-terminus of the integrase. The chromodomain exhibits structural ch...
<context> support of this view, CaMKII activity was also increased in hearts of transgenic mice overexpressing a gain-of-function Na(v)1.5 mutant (N(1325)S). The effects of both ATX-II and the N(1325)S mutation were reversed by either I(NaL) inhibition (with ranolazine or tetrodotoxin) or CaMKII inhibition (with KN93...
<context> Ranolazine and lidocaine (10 μM) similarly reduced Ca2+i overload and improved left ventricle work recovery in whole-heart models of IR injury or exposure to ouabain (80 μM). Ranolazine (10 μM), but not lidocaine (10 μM), reduced RM NCX1.1-mediated Ca2+i overload in ventricular myocytes. Blockade of the lat...
<context> High-glucose treatment resulted in increased intracellular calcium ([Ca2+]i) which was mobilized to the mitochondria. Concomitant intra-mitochondrial calcium ([Ca2+]m) increase resulted in enhanced reactive oxygen and nitrogen species generation. These events led to mitochondrial dysfunction and apoptosis. ...
<context> The data suggest that trimetazidine significantly improves cardiac function in db/db mice by attenuating lipotoxicity and improving the oxidation status of the heart. Activation of AMPK and decreased expression of PGC-1 alpha were involved in this process. the results demonstrated that TMZ is cardioprotecti...
<context> diabetes leads to cardiomyopathy in later stages with hypocontractility and reduced SERCA activity Previous studies with diabetes type 1 models have shown a down-regulation of SERCA2a in the heart associated with a decrease in systolic and diastolic function. the up-regulation of SERCA2a in the early phase ...
<context> Our results further substantiate that gene scanning of all relevant RET exons is a powerful tool in the management of MEN2 patients, We identified RET mutations in seven of 13 MTCs: five RET-positive cases revealed a mutation in exon 16 (M918T) and two a mutation in exon 10 (C618S and C620S). In four of the...
<context> Using a chemical carcinogenesis model in Sparc-deficient mice and their wild-type littermates, we found that loss of SPARC accelerated the development of urothelial preneoplasia (atypia and dysplasia), neoplasia, and metastasis and was associated with decreased survival. Our studies showed that inhibition o...
<context> Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain. Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. </con...
<context> This unit describes how to use the gene-finding programs GeneMark.hmm-E and GeneMark-ES for finding protein-coding genes in the genomic DNA of eukaryotic organisms. this paper we present an implementation of three computational pipelines (Fgenesh++, PSF and Fprom) for automatic identification of protein cod...
<context> Deer are the key hosts of the vector (Ixodes ricinus) that transmits LIV to red grouse Lagopus lagopus scoticus, causing high mortality. n Europe the primary arthropod vectors of zoonotic diseases are ticks, which transmit Borrelia burgdorferi sensu lato (the agent of Lyme disease), tick-borne encephalitis ...
<context> Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. CHG methylation by CHROMOMETHYLASE3 (CMT3) depends on histone H3K9 dimethylation (H3K9me2), but the mechanism underlying this relationship is poorly understood. Here, we report multiple lines of evid...
<context> The human selenoproteome consists of 25 selenoproteins. </context> <question> How many selenoproteins are encoded in the human genome? </question> <answer> 25 </answer>
<context> We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target We further found...
<context> Many plant, animal, and fungal genomes contain cytosine DNA methylation in asymmetric sequence contexts (CpHpH, H = A, T, C). However, at the SUPERMAN locus, asymmetric methylation was only completely abolished in drm1 drm2 chromomethylase 3 (cmt3) triple mutant plants. Although neither the drm1 drm2 double...
<context> MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression by interacting with the 3'UTR of protein-coding mRNA. MicroRNAs are implicated in nearly all major biological and cellular events, and recent findings further link microRNA deregulation to human carcinogenesis. MiR-657 p...
<context> Moreover, the identification of uric acid precipitates in P. falciparum- and P. vivax-infected erythrocytes obtained directly from malaria patients underscores the in vivo and clinical relevance of our findings. lasmodium falciparum the main causative agent of malaria is an important public health vector. M...
<context> Among these genes, SF3B1, encoding a subunit of the spliceosomal U2 small nuclear ribonucleoprotein (snRNP), is somatically mutated in 9.7% of affected individuals. Further analysis of these mutations in 363 patients with CLL identified four genes that are recurrently mutated: notch 1 (NOTCH1), exportin 1 (...
<context> The problem of finding an optimal structural alignment for a pair of superimposed proteins is often amenable to the Smith-Waterman dynamic programming algorithm, which runs in time proportional to the product of lengths of the sequences being aligned. The similarities between sequences can be determined by ...
<context> For instance, they are used to determine expression profiles of miRNAs, 20–24 nt long RNA molecules, that have emerged in recent years as important post-transcriptional regulators in all known multicellular organisms and that are known to play roles in development, tumorigenesis and viral infection (Bartel,...
<context> Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths. In contrast to protein-coding genes, however, lncRNAs display a striking bias toward two-exon transcripts hey are ...
<context> ecently, we have shown [19] that one fly, Drosophila willistoni, lacks selenoprotein genes, being the first animal reported to lack these proteins. More recently Lobanov et al. have reported that other insect genomes also appear to lack selenoproteins [20] We have also analyzed the sequences of all other av...
<context> , as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of splicing factor binding to their pre-mRNA target sites but also on transcription-associated features such as protein recruitment to the transcribing machinery and elongation ki...
<context> One of the most reliable prognostic markers in chronic lymphocytic leukemia (CLL) is the mutational status of immunoglobulin heavy variable (IGHV) genes, which defines 2 subsets, mutated CLL (M-CLL) and unmutated CLL (U-CLL), with different clinical courses. Mutational status of the immunoglobulin heavy cha...
<context> Nucleosomes preferentially are located at the ends of exons, thus protecting splice junctions, with the N9 positions of guanines of the GT and AG junctions oriented toward the histones. Nucleosomes were found to be preferentially positioned within constitutive exons and/or constitutive portions of alternati...
<context> We found that several types of histone modifications including H3K36me3 were associated with the inclusion or exclusion of alternative exons. Furthermore, we observed that the levels of H3K36me3 and H3K79me1 in the cell lines were well correlated with the differences in alternative splicing patterns between...
<context> A member of the p53 family, p73, has several isoforms and differentially regulates transcription of genes involved in the control of the cell cycle and apoptosis. The Trp73 gene belongs to the p53 family of transcription factors and, like the other members, is transcribed into different isoforms [1-4]. TP73...
<context> We show that Notch signaling is silenced in human AML samples, as well as in AML-initiating cells in an animal model of the disease. Comparative functional genomic analysis identified a signature of Notch activation in 30% of HCC samples from patients. Mutations in NOTCH2, a gene required for marginal-zone ...
<context> HTPB significantly inhibits cancer cell metastasis in vivo JNJ-26481585 also fully inhibited the growth of C170HM2 colorectal liver metastases, whereas again 5-fluorouracil/Leucovorin showed modest activity. Although not meeting the RECIST response criteria for adequate single-agent activity, the observed t...
<context> The prediction of the complete structure of genes is one of the very important tasks of bioinformatics, especially in eukaryotes. A crucial part in the gene structure prediction is to determine the splice sites in the coding region. Identification of splice sites depends on the precise recognition of the bo...
<context> Diabetic animals developed low triiodothyronine syndrome. They also showed that diabetes during the final 8 weeks (i) caused a marked impairment in the performance of perfused hearts ex vivo of hypertensive rats but had no measurable effect in the normotensive WKY, (ii) had no effect on arterial pressure of...
<context> Inhibition of MEF2A using siRNA attenuated HB-EGF-induced COX-2, ANF expression and cell size. This genetic reprogramming coincides with a pronounced increase in expression of the estrogen receptor (ER)alpha gene, which we show to be a direct MEF2 target gene cardiac calsequestrin gene (casq2) Functional st...
<context> n FM the reduced mRNA expression of ARB1 (p<0.05, -37%) and ARB2 (p<0.05, -42%) was associated with a reduction of the messenger for TRalpha1 (p<0.05, -85%) and TRalpha2 (p<0.05, -73%). hese data reveal that in human heart failure the reduction of beta-adrenergic receptors is associated with reduced express...
<context> We used a polymerase chain reaction (PCR)-based mRNA differential display (DD) analysis to obtain a profile of thyroid hormone-responsive genes in osteoblast-like cells At the 2-hour time point, 1 true-positive novel clone was identified and shown to be the mitochondrial gene, subunit 6 of ATP synthase (ATP...
<context> We recently reported that diabetes depresses AMP-activated protein kinase (AMPK) activity, inhibits MAPK8/JNK1-BCL2 signaling Activation of AMPK directly phosphorylates MAPK8, which mediates BCL2 phosphorylation and subsequent BECN1-BCL2 dissociation, leading to restoration of cardiac autophagy, protection ...
<context> IFT often is associated with a systemic extracervical fibrotic process and tobacco use. Attempted thyroid resection often results in postoperative complications. Long-term follow-up showed no deaths fro Riedel's invasive fibrous thyroiditis is a rare disorder of unknown origin with progressive extension and...
<context> 5IFNα can commonly induce thyroiditis, which is classified as either autoimmune or non-autoimmune interferon-induced thyroiditis (IIT).6 Autoimmune IIT manifests as Hashimoto's thyroiditis, which is defined by an emerge of or worse in antithyroid antibody levels with or without hypothyroidism. In rare cases...
<context> The terminal dinucleotides GT and AG at the 5' and 3' end of introns, respectively, are nearly universal [4-6]. However, compilation of introns with non-consensus splice sites [7,8] led to the discovery of a minute class of introns. These introns contained an extended and nearly invariant 5' splice site (AT...
<context> Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally. hey are under stronger selective pressure than neutrally evolving sequences-particularly in their promoter regions, which display levels of sel...
<context> Although in this study we focused on the antagonistic function of AIMP2-DX2 against the pro-apoptotic activity of AIMP2-F via p53 in response to DNA damage, it may also influence the normal activity of AIMP2 in these two other pathways with a similar mode of action, namely, through the competitive binding t...
<context> The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. More than 25% of Alu exons analyzed by RNA-Seq have estimated transcript inclusion levels of at least 50% in the human cerebellum, indicating widespread es...
<context> The tRNASec and the SECIS element, an RNA hairpin in the 3′UTR of selenoprotein mRNAs, and two trans-acting proteins, the specialized translation elongation factor eEFSec and the SECIS Binding Protein 2 (SBP2), are the key players of the recoding machinery ( Specialized protein complexes that involve SECp43...
<context> We identify a novel mutation in PHC1, a human orthologue of the Drosophila polyhomeotic member of polycomb group (PcG), which significantly decreases PHC1 protein expression, increases Geminin protein level and markedly abolishes the capacity to ubiquitinate histone H2A in patient cells. In clinical specime...
<context> tau hyperphosphorylation were dramatically reduced in hUCB-MSC transplanted APP/PS1 mice Administration of 7-nitroindazole to CMS-exposed old rats significantly (p=0.002) increased GAD activity, decreased glutamate levels (7.19+/-3.19 vs. 763.9+/-91 micromol/g tissue protein; p=0.0005), and decreased phosph...
<context> activating mutations in KRAS are identified in most pancreatic cancers Mutations at codon 12 of the K-ras gene are present in 65%-100% of carcinomas of human exocrine pancreas and could be used as a potential tumor marker at the tissue level. K-RAS mutation is observed in a third of IPMN adenomas and its mu...
<context> Rett syndrome is caused by mutations in the gene coding for methyl CpG-binding protein 2 (MeCP2). Rett syndrome is one of the most common causes of complex disability in girls. It is characterized by early neurological regression that severely affects motor, cognitive and communication skills, by autonomic ...
<context> Half of the human genome is composed of repeated DNA, and some types are mobile within our genome (transposons and retrotransposons). Despite their abundance, only a small fraction of them are currently active in our genome (Long Interspersed Element-1 (LINE-1), Alu, and SVA elements). Since certain types o...
<context> discovery that genes targeted by either p53 or E2F were respectively activated or repressed through repression of E6 and E7 The ability of high-risk HPV E6 and E7 protein to promote the degradation of p53 and pRb, respectively, has been suggested as a mechanism by which HPV oncogenes induce cellular transfo...
<context> Measures of RNA abundance are important for many areas of biology and often obtained from high-throughput RNA sequencing methods such as Illumina sequence data. These measures need to be normalized to remove technical biases inherent in the sequencing approach, most notably the length of the RNA species and...
<context> we find that using an anti-PD-1 antibody (CT-011) PD-1 blockade by CT-011, anti-PD-1 antibody, . Presence of CT-011, an anti-PD1 antibody, CT-011, a novel monoclonal anti-PD-1 antibody CT-011, a humanized antibody interacting with PD-1, Anti-PD1 (nivolumab and MK-3475) anti-PD-1 antibodies MK-3475 </conte...
<context> ILK knockdown had no effect on the viability or survival pathway activity pattern of MM cells. We conclude that ILK does not play a prominent role in the promotion or sustenance of established MM. Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts ...
<context> reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels. The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes. at hype...
<context> Iodothyronine deiodinase in vitro activity studies in the chicken showed the presence of type I and type III iodothyronine deiodinase activity in both liver and kidney. In embryonic chicken liver (ECL) two types of iodothyronine deiodinases are expressed: D1 and D3. In liver homogenates, D1 activity was not...
<context> Thyroxine (T4) is transported through the blood-brain barrier and converted to triiodothyronine (T3) to bind and activate thyroid hormone receptors (TR). This pathway is catalyzed by type 2 deiodinase (D2) in glial cells [3], [4], [5] from which T3 exits for uptake into TR-containing neurons to establish a ...
<context> Type 2 deiodinase (D2), the thyroid hormone (TH)-activating enzyme, is sharply upregulated during myoblast differentiation The iodothyronine deiodinases D1, D2, and D3 enable tissue-specific adaptation of thyroid hormone levels in response to various conditions, such as hypothyroidism or fasting. The possib...
<context> Iodothyronine deiodinase in vitro activity studies in the chicken showed the presence of type I and type III iodothyronine deiodinase activity in both liver and kidney. Co-expression of the deiodinases was also found in the kidney. high ID-I activities were found in liver, kidney the kidney microsome 5'-dei...
<context> Enteroviruses (EV) are an important cause of neonatal disease including hepatitis, meningoencephalitis, and myocarditis that can lead to death or severe long-term sequelae Enteroviruses have been considered to be the most common cause of acute myocarditis and possible consequence of dilated cardiomyopathy. ...
<context> ibuprofen 400 mg twice a day as therapy Acute fulminant myocarditis commonly manifests itself as severe, rapidly progressive hemodynamic deterioration and circulatory collapse that may be resistant to high doses of inotropic agents and steroids and to mechanical support by intra-aortic balloon pump the Tand...
<context> Recurrences develop in up to 20-50% of patients with acute pericarditis. Although different causes of recurrent pericarditis have been identified, the etiology remains obscure in most cases which are therefore labelled as idiopathic. A poor response to colchicine treatment and/or a steroid-dependence may be...
<context> Current therapeutic options include use of proton-pump inhibitors, immunosuppressive drugs, elimination diets, and esophageal dilatation. Aerosolized, swallowed fluticasone leads to a histologic but not a symptomatic response in adults with EoE OVB is an effective treatment of pan-esophageal disease in chil...
<context> good response to anti-thyroid drugs and steroid therapy The disease course of amiodarone-induced thyrotoxicosis is usually benign and remits with timely administration of anti-thyroid medications, with or without corticosteroids. RIT may be a safe and useful method of AIT therapy in patients with low RAIU, ...
<context> Prednisone remains the preferred treatment modality of AIT type 2, because perchlorate given alone or in combination with prednisone had no better outcomes. Total thyroidectomy, by rapidly restoring euthyroidism, may improve cardiac function and reduce the risk of mortality in AIT patients with severe LV dy...
<context> Triple therapy, which has been the mainstay of treatment in many countries over the last decade, now has suboptimal results in many parts of the world. equential therapy and quadruple therapy (either bismuth-based or non-bismuth-based) are the best current options to replace initial treatment with triple th...
<context> Three patients met the criteria for free T3 toxicosis and three had subclinical hyperthyroidism. All six patients had either multinodular glands or a single nodule on thyroid exam. Four patients were treated with radioactive iodine or surgery, resulting in reversal of the TSH suppression in three cases. 6 m...
<context> Some miRNAs as miR-1, miR-133 and miR-208a are highly expressed in the heart and strongly associated with the development of cardiac hypertrophy. Recent data indicate that these miRNAs as well as miR-206 change their expression quickly in response to physical activity. the miR-494 content significantly decr...
<context> Our major finding is that repeated very intense exercise prolongs life span in well trained practitioners. Death rates declined with increased levels of total activity (estimated in kilocalories), and declined also with increased intensity of effort measured as from none, to light, to moderately vigorous or...
<context> POM121 is involved in the fusion of inner and outer nuclear membranes in vitro. In this study, we show that the transmembrane Nup, POM121, but not the Nup107–160 complex, is required for the juxtapositioning of the INM and ONM Untreated cells and cells overexpressing Ndc1-GFP, another transmembrane Nup show...
<context> These proteins are targeted by chaperones and delivered to lysosomes where they are translocated into the lysosomal lumen and degraded via the lysosome-associated membrane protein type 2A (LAMP-2A) Macroautophagy is followed by chaperone-mediated autophagy (CMA), in which Hsc70 (Heat shock cognate 70) selec...