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<context> Our results show a high prevalence of RA in LAC women with a ratio of 5.2 women per man RA in LAC women is not only more common but presents with some clinical characteristics that differ from RA presentation in men. Some of those characteristics could explain the high rates of disability and worse prognosi...
<context> Gene fusion is an important evolutionary process. It can yield valuable information to infer the interactions and functions of proteins. Aside from their novelty, proteins with BLAST hits to two or more proteins in other organisms have been posited as Rosetta Stones since the fusion of two or more catalytic...
<context> De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3. Three functional classes of DNA methyltransferase exist in A.thaliana; METHYLTRANSFERASE1 (MET1) (orthologous to mammalian Dnmt1) which maintains CG methyla...
<context> ver the last few years, advances in methodology have made it possible to recover peptides from FFPE tissues that yield a reasonable representation of the proteins recovered from identical fresh or frozen specimens. Thus, laser capture microdissection of FFPE tissue coupled with downstream proteomic analysis...
<context> Different cutaneous side effects have been described for anti-TNF-α therapy such as psoriasis Anti-TNF drug-induced alopecia is a less well-known side effect of this class of drugs. 3 patients who developed scalp alopecia Psoriasis and psoriatic arthritis induced in a patient treated with infliximab for Cro...
<context> Tissue kallikreins are a group of closely related serine proteinases that are represented by multigene families in mice and rats. Our map specifies the distance between genes to one base pair accuracy, the relative location, and the direction of transcription of all 15 genes. The human tissue Kallikrein fam...
<context> The topologies of the trees were overall congruent: four monophyletic groups corresponding to the four plant C5-MTase families were clearly distinguished. In addition, sequence analyses of the plant C5-MTase target recognition domain sequences were performed and phylogenetic trees were reconstructed showing...
<context> miR-21* and miR-203 were significantly dysregulated (P < 0.05) in PTC tissues with BRAFV600E. Expressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation. Levels of miRNA-21 (miR-21) and miR-106a in gastric cancer tissues were significantly higher compared with th...
<context> antifungal protein KP4 Killer protein 4 (KP4) is a well studied viral toxin secreted by the maize smut fungus Ustilago maydis that kills sensitive Ustilago strains as well as inhibits Fusarium and plant root growth by inhibiting calcium uptake. Our previous work on a virally encoded fungal toxin, KP4, from ...
<context> higher rates are observed with anti-TNF Abs (e.g., infliximab) as compared with TNF receptor fusion protein (etanercept). Two of them received etanercept and the remainder adalimumab. with a possible differential risk between the three anti-TNF drugs: infliximab (INF) and adalimumab (ADA) (both monoclonal a...
<context> The histone marks appeared mainly in generic regions and were enriched around the transcription start sites (TSSs) of genes Tri-methylated H3 lysine 4 (H3K4me3) is associated with transcriptionally active genes, but its function in the transcription process is still unclear However, the catalytic function i...
<context> Using H3K4me2 as a mark for active enhancers Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across target loci by enhancers that function over long distances The enhancer region itself was marked by mono-methylation at K4 and K9, distinguishing it from the methyl ...
<context> In group 2 and 3, two anomalies, anorectal malformation and cystic fibrosis, were detected postnatally Six had chromosomal/genetic abnormalities, two had congenital cytomegalovirus, none had cystic fibrosis Primary bowel pathology is rare following the finding of FEB Maternal serology for cytomegalovirus (C...
<context> our analysis indicates that the association of CGIs with housekeeping genes is not as strong as previously estimated CpG islands are preferentially located at the start of transcription of housekeeping genes and are associated with tissue-specific genes It has been envisaged that CpG islands are often obser...
<context> the cannonical polyadenylation signal sequence AATAAA Two AATAAA motifs are coded in the last exon of this gene The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently the early poly(A) consen...
<context> yeast origins are characterized by an asymmetric pattern of positioned nucleosomes flanking the ACS. The origin sequences are sufficient to maintain a nucleosome-free origin; however, ORC is required for the precise positioning of nucleosomes flanking the origin. ORC binds to Nucleosome free regions (NFRs) ...
<context> he etiology of subacute (de Quervain's) thyroiditis (SAT) is uncertain, although it probably represents a nonspecific inflammatory response by the thyroid to a variety of viruses. Subacute thyroiditis is an inflammatory disorder of the thyroid caused probably by viruses. I We believe that the etiologic agen...
<context> we identified three interferon-stimulated genes (ISGs; Ifi27, Irg1 and Rsad2 (also known as Viperin)) that mediated the antiviral effects against different neurotropic viruses IRG1 is highly upregulated in murine ANA-1 macrophages by several proinflammatory cytokines and Toll-like receptor (TLR) agonists, a...
<context> Putative HCNE peak targets are characterized by a tight association with particular promoter motifs, higher incidence of severe mutant phenotypes, and evidence of a more precise regulation of gene expression during important developmental transitions Much evidence suggests that CNEs are selectively constrai...
<context> experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis Therefore, a well characterized homogeneous animal model, experimental autoimmune encephalomyelitis (EAE), was selected for this study to obtain a sample of the inflammatory lesions using experimental allergic encephalomyelit...
<context> transcriptional enhancers in developing mouse embryos, found that the enhancers directed reporter expression most frequently in the brain and neural tube. More recently, a similar association between ultraconserved noncoding elements (noncoding sequences exceedingly conserved in human, chimp and mouse) and ...
<context> Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetr...
<context> The FGFR3 P250R mutation was the single largest contributor (24%) to the genetic group FGFR3 P250R and FGFR2 exons IIIa/c) should be targeted to patients with coronal or multisuture synostoses GNAS, the gene for guanine nucleotide-binding protein, alpha-stimulating activity polypeptide (gene for PHP1A), ide...
<context> role of primary cilia in autosomal dominant polycystic kidney disease Recent research has focused on defects in signaling mediated by the primary cilia as the causative factor in ADPKD Interestingly, primary cilia concentrate p75NTR receptors in their membranes and are abnormally structured/damaged in trans...
<context> The allelic frequency of this variant was calculated to be 0.7% for this population The results of literature reviews, surveys, and registry analyses revealed a mean prevalence of 0.737/10,000 in the 27 EU countries, which is similar to the value of 0.797 in the United States, and only one outlier, namely t...
<context> interactions with alpha-expansin in cell wall extension and polysaccharide degradation cell wall swelling may not be a significant event during the action of expansin and hydrolases To evaluate a putative implication of three newly identified expansin/family 45 endoglucanase-like (EEL) proteins in lignocell...
<context> Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus. Influenza immunization or infection may cause subacute thyroiditis. Coxsackie virus has been reported to be one of the viruses associated with the disease. The ...
<context> Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown...
<context> ommonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfere with the absorption of levothyroxine Hypothyroid patients taking sevelamer hydrochlo...
<context> Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. I In addition, miR-21, -24, -133, -210, -494, and -499 appear to protect myocytes against I/R-induced apoptosis,...
<context> The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosi Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore see...
<context> GD orbital fibroblasts, which comprise a mixture of CD34(+) and CD34(-) cells, express much lower levels of Tg and TSHR Previously, we found that CD34(+) progenitor cells, known as fibrocytes, express functional TSHR, infiltrate the orbit, and comprise a large subset of orbital fibroblasts in TAO. TSH indu...
<context> T3-induced cardiac sprouting angiogenesis in adult hypothyroid mice was associated with PDGF-BB, PDGFR-β and downstream activation of Akt. L-T3 significantly increased angiogenesis and cell survival and enhanced the expression of nuclear-encoded transcription factors involved in these processes. T(3) admini...
<context> The product of the dcm gene is the only DNA cytosine-C5 methyltransferase of Escherichia coli K-12; it catalyses transfer of a methyl group from S-adenosyl methionine (SAM) to the C-5 position of the inner cytosine residue of the cognate sequence CCA/TGG. Deoxycytosine methylase (Dcm) enzyme activity cause...
<context> Most luminal lysosomal proteins are synthesized as precursors containing mannose 6-phosphate (Man6-P) and a number of recent studies have conducted affinity purification of Man6-P containing proteins as a step toward defining the composition of the lysosome This chapter describes the process of production, ...
<context> The lysosomal storage disorder Fabry disease is characterized by excessive globotriaosylceramide (Gb3) accumulation in major organs such as the heart and kidney. Defective lysosomal alpha-galactosidase A (Gla) is responsible for excessive Gb3 accumulation, and one cell sensitive to the effects of Gb3 accumu...
<context> Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus </context> <question> What is known as the cause of subacute thyroiditis? </question> <answer> Most cases of subacute thyroiditis are caused by a variet...
<context> Oral glucocorticoids are administered in moderate and severe cases of subacute thyroiditis (SAT) he treatment protocol that we employed had 15 mg/day of PSL as the initial dosage for the treatment of SAT, with tapering by 5 mg every 2 weeks </context> <question> What is the treatment of subacute thyroi...
<context> myc regulates hepatic glycolysis increase in c-Myc protein was able to induce liver glucose utilization and accumulation, and suggested that c-Myc transcription factor is involved in the control in vivo of liver carbohydrate metabolism p53 regulates mitochondrial oxidative phosphorylation, glycolysis, gluta...
<context> Recent evidence indicates that CXCR2 signaling is crucial for cancer progression, and its antagonist SB225002 induces apoptosis in Wilms' tumor cells. CXCR2 small-molecule antagonist (SB225002) G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nud...
<context> In contrast, GeneView recognizes a broader set of entity types but not gene ontology terms, provides search facilities using unique database identifiers and also finds relationships between proteins in texts. It uses a multitude of state-of-the-art text-mining tools optimized for recognizing mentions from 1...
<context> The paraspeckle component 1 (PSPC1) and non-POU-domain-containing octamer-binding protein (NONO) heterodimer is an essential structural component of paraspeckles, PSPC1-NONO heterodimer. Crystallization of a paraspeckle protein PSPC1-NONO heterodimer difficult heterodimeric complex of two human proteins, pa...
<context> , a mixture of five SILAC-labeled cell lines that accurately represents the tissue We describe a method to accurately quantify human tumor proteomes by combining a mixture of five stable-isotope labeling by amino acids in cell culture (SILAC)-labeled cell lines with human carcinoma tissue. the use of a mix...
<context> In this work, we propose a method based on radial basis networks for predicting the number of beta-strands in OMPs and identifying their membrane spanning segments. We have developed a web server, TMBETAPRED-RBF for predicting the transmembrane beta-strands from amino acid sequence and it is available at ht...
<context> Toward Single Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry. he advent of proteomics and genomics at a single-cell level has set the basis for an outstanding improvement in analytical technology and data acquisition. The new-generation technology of single-ce...
<context> In conjunction with the XFEL temporal profile and high-flux, it is a powerful tool for studying the dynamics of time-dependent systems. Photo-induced processes and fast catalytic reaction kinetics, ranging from femtoseconds to milliseconds, will be resolvable in a wide array of systems circumventing radiati...
<context> Multiple endocrine neoplasia type 1 (MEN1; formerly known as Wermer syndrome) is a rare disorder characterized by the combined occurrence of two or more tumors involving parathyroid, pancreatic islets and anterior pituitary glands; some other tumors have also been described. Hyperparathyroidism is the most...
<context> The autoantibodies implicated in the Lambert-Eaton myasthenic syndrome (LES), which are known to inhibit ICa and INa in bovine adrenal chromaffin cells, also significantly inhibited INa in SCLC cells. These results indicate that (i) action potentials in human SCLC cells result from the regenerative increase...
<context> Krabbe disease is a lethal, demyelinating condition caused by genetic deficiency of galactocerebrosidase (GALC) and resultant accumulation of its cytotoxic substrate, psychosine (galactosylsphingosine), primarily in oligodendrocytes (OLs). In this study, we report that accumulation of endogenous psychosine ...
<context> he miRNAs miR-126 and miR-508-5p are associated with the outcome of ICM and NICM patients with CHF. These two miRNAs could be useful in the diagnosis of CHF patients, and might provide novel targets for prevention and treatment of CHF. The plasma concentration of miR-126 was negatively correlated with age a...
<context> Dabigatran etexilate is a novel oral direct thrombin inhibitor, which provides stroke risk reduction for patients with nonvalvular atrial fibrillation. Dabigatran is a potent reversible, competitive direct thrombin inhibitor which is available as the prodrug, Dabigatran etexilate. The recently introduced o...
<context> In the intermediate-risk subgroup, the 70-gene signature could be useful to decide in elderly patients whether they may benefit from adjuvant chemotherapy or not. One of the new prognostic markers is the 70-gene prognostic signature (MammaPrint™; Agendia, Amsterdam, Netherlands) Analysis of gene expression ...
<context> Thus, rosiglitazone's neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation. Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphat...
<context> In 2008, the American Heart Association (AHA) recommended a 2-step screening method, consisting of the 2-item Patient Health Questionnaire (PHQ-2) followed by the 9-item Patient Health Questionnaire (PHQ-9), for identifying depression in cardiovascular patients. The American Heart Association (AHA) statemen...
<context> an FDA-cleared 70-gene signature of MammaPrint panel on MammaPrint, the first and only assay for breast cancer management that has been cleared by the FDA. The MammaPrint assay has the advantages of a 510(k) clearance by the US Food and Drug Administration, a larger gene number which may enhance further ut...
<context> Pharmacogenetic studies have revealed that abacavir HSRs are highly associated with the major histocompatibility complex class I. Large studies established the effectiveness of prospective HLA-B*57:01 screening to prevent HSRs to abacavir. Accordingly to these results the abacavir label has been modified: t...
<context> Entacapone is a highly potent, reversible, peripherally acting catechol-O-methyl transferase (COMT) inhibitor that is used as an adjunct to L-dopa in the treatment of patients with Parkinson disease (PD). Stalevo is a combination tablet comprised of levodopa, carbidopa, and the COMT inhibitor entacapone. It...
<context> There are two identified genes that are responsible for the main proportion of the genetic effect: CYP2C9, which codes for the enzyme cytochrome P450 2C9 that metabolizes S-warfarin, and VKORC1, which codes for warfarin's target, vitamin K epoxide reductase. We identified ORM1 as another polymorphic gene af...
<context> The calcium channel blocker verapamil is the drug of choice for CH prevention. Other drugs that may be used for this purpose include lithium carbonate, topiramate, valproic acid, gabapentin, and baclofen. Recently, the therapeutic options for refractory CH patients have expanded with the emergence of both p...
<context> The recognition of sustained androgen dependence of CRPC has led to the identification of more potent and selective inhibitors of androgen synthesis and androgen-receptor signaling, such as abiraterone and enzalutamide, respectively. This review summarizes the rationale, mechanism of action and relevant cli...
<context> NF-1 is caused by loss of function mutations in the NF1 gene in 17q11.2. The von Recklinghausen neurofibromatosis (NF1) gene has been localized to the pericentromeric region of chromosome 17. Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African famili...
<context> A PLN founder mutation (43 cases) and LMNA mutations (19 cases, 16 different mutations) were most prevalent and often demonstrated a specific phenotype. PLN mutation R14del was identified in 12 (12 %) ARVC patients and in 39 (15 %) DCM patients The PLN R14del founder mutation is present in a substantial num...
<context> NGS sequencing data for a particular genomic region can be seen as the summation of all the individual sequences (reads) obtained for that region and no longer as the mean of this sum as it is the case for traditional Sanger sequencing. Hereby we present the proof of principle of a NGS based mutation screen...
<context> This article discusses some of these unresolved issues, including the use of medications such as nimodipine, antifibrinolytics, statins, and magnesium; coiling or clipping for aneurysm securement; and the prevention and treatment of potential complications. The results of this study were as follows: nimodip...
<context> Pyridostigmine is the most widely used acetylcholinesterase inhibitor. For more than 50 years the acetylcholinesterase inhibitor pyridostigmine bromide has been the drug of choice in the symptomatic therapy for myasthenia gravis. The switch to SR-Pyr ameliorated the total quantified myasthenia gravis (QMG)...
<context> The Center of Epidemiological Studies-Depression Scale (CESD) (sensitivity: 0.75; 95% CI 0.60 to 0.85; specificity: 0.88; 95% CI 0.71 to 0.95), the Hamilton Depression Rating Scale (HDRS) (sensitivity: 0.84; 95% CI 0.75 to 0.90; specificity:0.83; 95% CI 0.72 to 0.90) and the Patient Health Questionnaire (PH...
<context> BETAWARE: a machine-learning tool to detect and predict transmembrane beta-barrel proteins in prokaryotes Recently, we developed two top-performing methods based on machine-learning approaches to tackle both the detection of TMBBs in sets of proteins and the prediction of their topology. Here, we present ou...
<context> We implemented, PPInterFinder--a web-based text mining tool to extract human PPIs from biomedical literature. PPInterFinder uses relation keyword co-occurrences with protein names to extract information on PPIs from MEDLINE abstracts PPInterFinder--a mining tool for extracting causal relations on human prot...
<context> MosaicFinder: Identification of fused gene families in sequence similarity networks This leads to an efficient formulation of previous methods of fused gene identification, which we implemented in the Python program FusedTriplets. We implemented this method in the C++ program MosaicFinder, which additionall...
<context> we illustrate arrangement diversity within closely related organisms, estimate arrangement turnover frequency and establish, for the first time, branch-specific rate estimates for fusion, fission, domain addition and terminal loss. Rate and polarity of gene fusion and fission in Oryza sativa and Arabidopsis...
<context> The illicit drugs more commonly associated with stroke are psychomotor stimulants, such as amphetamine and cocaine. Less commonly implicated are opioids and psychotomimetic drugs, including cannabis. Among 326 patients (184 males), the most frequent stroke risk factors overall were dyslipidaemia (187), smok...
<context> Opioid overdose has a high mortality, but is often reversible with appropriate overdose management and naloxone (opioid antagonist). Training clinicians how to manage an opioid overdose and administer naloxone was effective. For patients who have ingested dextromethorphan and are sedated or comatose, nalox...
<context> Benzodiazepine (BZD) overdose (OD) continues to cause significant morbidity and mortality in the UK. Flumazenil is an effective antidote but there is a risk of seizures, particularly in those who have co-ingested tricyclic antidepressants. Flumazenil was administered to 80 patients in 4504 BZD-related enqui...
<context> The Oncotype-DX Breast Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21 genes in breast cancer tissue by performing reverse transcription polymerase chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks that are obtained during initial surgery (lum...
<context> The 70-gene signature (MammaPrint™) The 70 gene-signature (MammaPrint(®)) is a prognostic profile of distant recurrence and survival of primary breast cancer (BC) The 70-gene signature was analysed using MammaPrint the prognostic value of the MammaPrint(TM) signature by the 70-gene signature the 70-gene sig...
<context> Prognostic and predictive markers Oncotype DX® currently allow avoidance of an over therapy or under therapy a high score on the Oncotype DX gene expression profile r poor-prognosis ER-positive breast cancers in need of more aggressive therapy luminal B class The 21-gene recurrence score (Oncotype DX: RS) a...
<context> The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing. the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuz...
<context> Functional connectivity in the default mode network (DMN) is known to be reduced in patients with disorders of consciousness, to a different extent depending on their clinical severity. Patients showed significant impairments in all of the pathways connecting cortical regions within this network, as well as...
<context> Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of ovary but have rarely been reported in other neoplasms and nonneoplastic lesions. Studies on serous cystadenocarcinoma of ...
<context> Prolactinoma is the most common secreting pituitary adenoma. It is typically diagnosed in women of reproductive age and is common cause of infertility. Examination of the tissue excised by transsphenoidal excision of the mass showed a pituitary adenoma that stained strongly for FSH. RESULTS: Regular menses ...
<context> To evaluate the cost effectiveness of the four medications with a US FDA-approved indication for PMDD: fluoxetine, sertraline, paroxetine and drospirenone plus ethinyl estradiol (DRSP/EE). All SSRIs (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and clomipramine) were effective in reducing pr...
<context> During the subacute phase, the irreversible damage expands into the penumbra: multiple electrical and biological signals are triggered by periinfarct, spreading depression-like depolarizations leading to hypoxia and stepwise increase in lactate. Experimental and clinical studies indicate that waves of corti...
<context> Here we show that the Orbitrap mass analyzer can be used to measure protein assemblies of molecular weights approaching one megadalton with sensitivity down to the detection of single ions. Using this relationship we show that we can determine masses of both 30S subunits and intact 2.3 MDa 70S ribosomes fro...
<context> Besides the baseline characteristics, daily interleukin-6 (IL-6), procalcitonin, C-reactive protein levels, and leukocyte counts were prospectively measured until day 14 after subarachnoid hemorrhage. Occurrence of infectious complications and application of therapeutic hypothermia were assessed as confound...
<context> Before surgery 27 patients (35%) had BDI scores indicating the presence of depression. These scores were significantly higher in patients with a history of depression (p = 0.017) and in those with a lower functional outcome (p = 0.015). A lower functional status (KPS score < or = 70) in patients was signif...
<context> Reduced positive affect and depression/anxiety were associated with poor prognosis, but reduced positive affect was the only independent predictor of events. The incidence of death/MI in adequate versus reduced positive affect patients was 4% (29/663) vs. 11% (23/211); HR = 2.55 (95% CI 1.46-4.34, P = 0.001...
<context> Sildenafil citrate (SIL) generic sildenafil (Unison Laboratories, Thailand) was proved to have the same bioequivalent as in the original formula. The authors conducted a 12-week case series to study the efficacy and safety of Elonza (generic sildenafil) Viagra tablets or generic versions containing sildenaf...
<context> Treatment with sildenafil was less costly and resulted in a greater gain in quality-adjusted life-years (QALYs) compared with other treatments. Based on this model, sildenafil is a cost-effective treatment for PAH with a low price and a net increase in QALYs. Four treatment strategies, Viagra, Rivastigmine...
<context> Generic switch after ramipril patent expiry is not associated with decreased pharmacy refill compliance: a retrospective study using the DAPI database. The costs per DDD decreased for all three drugs and, as expected, these costs decrease more rapidly after patent expiry. Significant differences in the tren...
<context> Of the 17 Paediatric Investigation Plans submitted, 14 have resulted in an EMA Decision, 3 were withdrawn by the applicants, 8 were granted a full waiver from development, and 1 resulted in a negative opinion. Decisions as issued included 15 clinical trials, with at least 1,282 children to be recruited into...
<context> The authors conducted a 12-week case series to study the efficacy and safety of Elonza (generic sildenafil) in PAH patients. SildenafilCavertaNot providedNot providedNot ProvidedNot ProvidedSan Diego, California, United Stateswww.worldexpress.comZenegra-100Mepro PharmZA 200202-03Mumbai, Maharashtra, IndiaMo...
<context> Longitudinal analysis showed that in Eut men higher baseline FT4 was significantly (p = 0.02) predictive of a lower SPPB score at the 3-year follow-up Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men. Oral L-thyroxine treatment was started and at a 1-month f...
<context> Mutations in the myotubularin 1 gene (MTM1) have been identified in the most of the patients with the X-linked recessive form. their conditions were diagnosed by genetic testing of MTM1. X-linked myotubular myopathy (MTM) is a severe neuromuscular disease of infancy caused by mutations of MTM1, which encode...
<context> patients receiving abacavir develop a hypersensitivity reaction, characterized by rash, fever and, occasionally, multisystemic involvement The predictors included any one of several specific symptoms commonly found with this reaction, a claims diagnosis of adverse effect of drug, anaphylactic shock or unspe...
<context> The histidine-rich Ca-binding protein (HRC) is a Ca-storage protein in cardiac sarcoplasmic reticulum. Recent transgenic studies revealed that this protein inhibits the maximal rates of sarcoplasmic reticulum Ca-transport, leading to cardiac dysfunction. In view of the role of sarcoplasmic reticulum Ca-cycl...
<context> Mutations in the epidermal growth factor receptor gene (EGFR) are frequently observed in non-small-cell lung cancer (NSCLC), EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, have transformed therapy for patients with EGFR-mutant NSCLC and have proved superior to chemotherapy as first...
<context> A strong association between human leukocyte antigen (HLA)-B*1502 and CBZ-induced SJS/TEN has been reported in Han Chinese, Thai, Malaysian and Indian populations, but not in Caucasian or Japanese populations. found a strong association between HLA-B*1502 and CBZ-induced SJS/TEN in the Han Chinese populatio...
<context> Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the elective treatment. We retrospectively compared two group of patients, who underwent surgery for GIST before and after Imatinib advent in order to analyze the recurrence and survival...
<context> trastuzumab (Herceptin®) an antibody-based therapy exists which is successfully used clinically for targeting HER2 in metastatic HER2-positive breast cancer over-expression of HER2 is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. In patients with advanced gast...
<context> polymorphisms in the CYP2C19 gene affect clopidogrel pharmacokinetics. This study sought to evaluate the influence of single nucleotide polymorphisms (SNPs) on the pharmacodynamic effect of high- or standard-dose clopidogrel after percutaneous coronary intervention (PCI). CYP2C19, but not PON1 or ABCB1, is ...