sentence string | label sequence | id string |
|---|---|---|
Hypoxic events frequently occur in the aquatic environment in association with micro pollutants , including heavy metals . Only a few studies are however available on the uptake and biological responses of heavy metals under hypoxic conditions . To elucidate the phenomenon , mirror carp Cyprinus carpio L . ( 16.13-16.2... | [
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A 51-year-old previously healthy man , an ex-smoker , was admitted to the authors ' medical department with a 3-month history of dry cough ; intermittent fever ; painless , ulcerated cutaneous lesions over the trunk and limbs ( Figure 1 ) ; and progressive weight loss . He was of Greek descent . His medical history was... | [
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MicroRNAs ( miRs ) are small non-coding RNAs that recently emerged as potent regulators of gene expression . The members of the miR-17-92 cluster have been shown to control endothelial cell functions and neovascularization ; however , the regulation and function of the cluster in endothelial cell lineage commitment has... | [
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The solution structure of the complex of enzyme IIA of the N,N'-diacetylchitobiose ( Chb ) transporter with the histidine phosphocarrier protein HPr has been solved by NMR . The IIA(Chb)-HPr complex completes the structure elucidation of representative cytoplasmic complexes for all four sugar branches of the bacterial ... | [
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Immunosuppression of humoral and cellular responses following chronic oral exposure to 1 , 5 , 10 , and 20 ppm N-nitrosodimethylamine ( NDMA ) was examined in CD-1 mice . Monitoring of cumulative mortality and the incidence of peritoneal ascites in animals showed an NDMA dose-related mortality and hepatotoxicity . No v... | [
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AIMS Tumour cell growth results from a disturbance in the balance between the rate of proliferation and cell death . In this study , proteins involved in the regulation of cell cycle arrest and apoptosis were studied as possible factors responsible for uncontrolled cell growth in colorectal cancer . METHODS The express... | [
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] | 11896073 |
The radioprotective effects of dimethyl sulfoxide ( DMSO ) have been known for many years , and the suppression of hydroxyl ( OH ) radicals induced by ionizing radiation has been thought to be the main cause of this effect . However , the DMSO concentration used was very high , and might be toxic , in earlier studies .... | [
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Androgens regulate both the physiological development of the prostate and the pathology of prostatic diseases . However , the mechanisms by which androgens exert their regulatory activities on these processes are poorly understood . In this study , we have determined that androgens regulate overall cell metabolism and ... | [
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] | 23250485 |
Cis-diamminedichloroplatinum ( II ) ( cisplatin ) is a well characterized antitumor drug used for the treatment of a variety of human cancers . The cytotoxicity of cisplatin is mainly mediated through the formation of DNA adducts , which are also believed to be responsible for the secondary malignancies produced by the... | [
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A prominent feature of inflammatory diseases is endothelial dysfunction . Factors associated with endothelial dysfunction include proinflammatory cytokines , adhesion molecules , and matrix degrading enzymes . At the transcriptional level , they are regulated by the histone deacetylase sirtuin ( SIRT ) 1 via its action... | [
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] | 23132960 |
MicroRNAs ( miRNAs ) are small noncoding RNAs , 19-24 nucleotides in length , that regulate gene expression and are expressed aberrantly in most types of cancer . MiRNAs also have been detected in the blood of cancer patients and can serve as circulating biomarkers . It has been shown that secreted miRNAs within exosom... | [
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The aim of the present study was to isolate endothelial cells from tooth buds ( unerupted deciduous teeth ) of miniature swine . Mandibular molar tooth buds harvested from swine fetuses at fetal days90-110 were cultured in growth medium supplemented with 15% fetal bovine serum in 100-mm culture dishes until the primary... | [
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Glioma tumors are refractory to conventional treatment . Glioblastoma multiforme is the most aggressive type of primary brain tumors in humans . In this study , we introduce oxidative stress-energy depletion ( OSED ) therapy as a new suggested treatment for glioblastoma . OSED utilizes D-amino acid oxidase ( DAO ) , wh... | [
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] | 21921941 |
Solar ultraviolet radiation is considered to be injurious rather than necessary for most organisms living on the earth . It is reported that the risk of skin cancer in humans increases by the depletion of the ozone layer . We have examined the genotoxicity of solar ultraviolet , especially the longer wavelength light ,... | [
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] | 12659514 |
Genetic immunotherapy with tumor antigen gene-modified dendritic cells ( DC ) generates robust immunity , although antitumor protection is not complete in all models . Previous experience in a model in which C57BL/6 mice immunized with DC transduced with adenoviral vectors expressing MART-1 demonstrated a 20-40% comple... | [
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] | 12386826 |
Recently , the use of gold nanoparticles as potential tumor selective radiosensitizers has been proposed as a breakthrough in radiotherapy . Experiments in living cells and in vivo have demonstrated the efficiency of the metal nanoparticles when combined with low energy x-ray radiations ( below conventional 1 MeV Linac... | [
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] | 20101074 |
Over the past two decades , bioactive natural compounds have been shown to be a plausible adjunct to the treatment of breast cancer , the second leading cause of cancer death among American women . This study was designed to investigate the effects of ursolic acid ( UA ) , a pentacyclic triterpene found in many foods a... | [
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BACKGROUND : The immune system has been shown to play an important role in gastrointestinal stromal tumor ( GIST ) . The neutrophil-to-lymphocyte ratio ( NLR ) in blood is an easily assessable parameter of systemic inflammatory response . The aim of this study was to determine whether the NLR is prognostic in GIST . ME... | [
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] | 23054118 |
A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication . Simultaneously , however , it may also enhance antitumor therapy through initiation of proinflammatory , antiviral cytokine responses at the tumor site . The aim of this study was to investig... | [
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] | 20016540 |
Liver cancer ranks as the fifth most prevalent malignancy of all cancers worldwide . According to the principles of traditional Chinese medicine , liver Yin deficiency is a common clinical syndrome of liver cancer , and tonifying liver Yin is a common treatment method for liver cancer . However , no hepatocarcinoma-spe... | [
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] | 22969849 |
We have recently proposed a new model of cancer metabolism to explain the role of aerobic glycolysis and L-lactate production in fueling tumor growth and metastasis . In this model , cancer cells secrete hydrogen peroxide ( H2O2 ) , initiating oxidative stress and aerobic glycolysis in the tumor stroma . This , in turn... | [
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] | 22313602 |
Mps one binder 1a ( MOB1A ) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers . Here we show that intact Mob1a or Mob1b is essential for murine embryogenesis and that loss of the remaining WT Mob1 allele in Mob1a(\u0394/\u0394)1b(tr/+) or Mob1a(\u0394/+)1b(... | [
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] | 23143302 |
OBJECTIVES/HYPOTHESIS Head and neck squamous cell carcinoma ( HNSCC ) is a complex disease process involving interactions with carcinoma-associated fibroblasts and endothelial cells . We further investigated these relationships by suppressing stromal cell growth through the inhibition of fibroblast growth factor recept... | [
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] | 22460537 |
There are contradictory observations about the different radiosensitivities of cancer stem cells and cancer non-stem cells . To resolve these contradictory observations , we studied radiosensitivities by employing breast cancer stem cell ( CSC)-like MDA-MB231 and MDA-MB453 cells as well as their corresponding non-stem ... | [
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] | 23185620 |
Hormone replacement therapy , which is a common menopausal treatment , is contraindicated in women with breast cancers due to concerns regarding the potential for breast cell proliferation . As such , there is a need for alternative methods for treating menopausal symptoms . To determine the influence of one such alter... | [
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] | 12408370 |
We have recently developed surface-shielded transferrin-polyethylenimine ( Tf-PEI)/DNA delivery systems that target reporter gene expression to distant tumors after systemic application . In the present study , we used surface-shielded Tf-PEI/DNA complexes for delivering the gene for a highly potent cytokine , tumor ne... | [
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] | 12136428 |
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis . The possibility was tested that interleukin-8 ( IL-8 ) , which is a cytokine that is chemotactic for lymphocytes and neutrophils , is also angiogenic . Human... | [
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] | 1281554 |
We have observed previously that treatment of plateau-phase L5178Y murine lymphoblasts in vitro with 2'-deoxycoformycin plus deoxyadenosine ( dCF/dAdo ) can inhibit the repair of X-irradiation-induced DNA single-strand breaks ( SSB ) in these cells and that this effect is associated with synergistic cell kill . In this... | [
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] | 1282003 |
Src kinase is elevated in breast tumors that are ER/PR negative and do not overexpress HER2 , but clinical trials with Src inhibitors have shown little activity . The present study evaluated preclinical efficacy of a novel peptidomimetic compound , KX-01 ( KX2-391 ) , that exhibits dual action as an Src and pretubulin ... | [
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] | 22784709 |
PURPOSE Overproduction of reactive oxygen species ( ROS ) intermediates above the functional capability of cellular antioxidants may result in instability of important macromolecules and represents the molecular basis of many diseases including inflammation processes , cardiovascular alterations , cancer etc . The purp... | [
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] | 20658731 |
Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with exposure to silica . Rats were exposed to crystalline silica by inhalation ( 15 mg m(-3) , 6 h per day , 5 days ) and global gene expression profile... | [
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] | 22431001 |
Neutrophils have become recognised as important contributors to the effectiveness of tumour eradication by photodynamic therapy ( PDT ) . In this study , we have used the mouse SCCVII squamous cell carcinoma model to investigate the activity of neutrophils in tumours treated by PDT . Tumour levels of neutrophilic myelo... | [
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] | 12665307 |
There is increasing evidence for the implication of tumor-derived angiogenic and anti-angiogenic factors in controlling tumor growth in vivo . In this study , we documented the production of inhibitors of angiogenesis by pancreatic cancer cells and examined how changes in the balance between pro- and anti-angiogenic fa... | [
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] | 12831059 |
AIM To compare the value of intravenous contrast-enhanced ultrasonography ( US ) , intravenous contrast-enhanced computed tomography ( CT ) , and magnetic resonance imaging ( MRI ) in the diagnosis of hepatic hemangiomas . MATERIAL AND METHODS The study enrolled 48 patients , aged between 20 and 79 years ( 35 [ 72.9% ]... | [
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] | 20679748 |
BACKGROUND Angiogenic factors following oncological surgery is important in tumor recurrence . Vascular endothelial growth factor ( VEGF ) , angiopoietin 1 ( Ang-1 ) , Ang-2 , soluble VEGF-receptor 1 ( sVEGFR1 ) and sVEGFR2 may influence angiogenesis . This prospective study examined the influence of open and video-ass... | [
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] | 23024612 |
BACKGROUND Prostate cancer ( PCa ) progression is often associated with transactivation of the androgen receptor ( AR ) by endogenous hormones/growth factors . One such factor affecting growth , proliferation , and apoptostis ( pro-/anti- ) in various cancers is the adipokine leptin . This research studied leptin-induc... | [
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1,
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] | 21541970 |
Novel strategies are necessary to improve chemotherapy response in advanced and recurrent endometrial cancer . Here , we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger ( SDGE ) are potent inhibitors of proliferation of endometrial cancer cells . SDGE , isolated from six different batches o... | [
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] | 23300887 |
Inflammatory responses and associated products have been implicated in cancer metastasis . However , the relationship between these two processes is uncertain due to the lack of a suitable model . Taking advantage of localized and controllable inflammatory responses induced by biomaterial implantation and the capabilit... | [
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] | 22019117 |
It is well known that cell-mediated immunity is suppressed in patients with neoplastic diseases . We have reported that soluble receptors for interleukin-2 ( sIL-2R ) and tumor necrosis factor ( sTNF-R1 ) are elevated in the serum of patients with advanced colorectal cancer . The presence of these soluble receptors and... | [
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0,
0
] | 11901535 |
MicroRNAs ( miRNAs ) are small non-coding RNAs of nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts . Notably , deregulation of miRNAs expression is associated with the initiation and progression of ... | [
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] | 22408395 |
An acquired mutation ( T790M ) in the epidermal growth factor receptor ( EGFR ) accounts for half of all relapses in non-small cell lung cancer ( NSCLC ) patients who initially respond to EGFR kinase inhibitors . In this study , we demonstrated for the first time that EGFR-T790M interacts with the cytoskeletal componen... | [
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1,
1,
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] | 22366308 |
The results of experimental studies have indicated the pleiotropic effects of statins in organism , e.g. the influence on cell cycle , apoptosis or angiogenesis . In this study , the effects of simvastatin on selected parameters of apoptosis and proliferation in chemocarcinogen-induced mammary tumorigenesis in female r... | [
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1,
0,
0
] | 22668016 |
Estrogen receptor ( ER ) and NF-κB are transcription factors with profound effects on breast cancer cell proliferation and survival . While many studies demonstrate that ER and NF-κB can repress each other , we previously identified a gene signature that is synergistically upregulated by these two factors in more aggre... | [
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1,
1
] | 22083956 |
We investigated the mode of cell death induced by the anthracyclines , aclarubicin , doxorubicin and daunorubicin in the human leukemia cell lines , HL60 and Jurkat . The cells were incubated with drug concentrations up to 500 nM for periods between 3 and 24 hours , followed by morphological and biochemical analyses . ... | [
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] | 12370496 |
BACKGROUND & OBJECTIVE Usually pituitary adenomas are histological benign and grow slowly , but a proportion of them will become locally aggressive , and develop into invasive pituitary adenomas . The reasons for these differences in tumor behavior are poorly understood . Pituitary adenomas are abounding blood vessels ... | [
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0,
0
] | 12508658 |
The biological activities of tocotrienols are receiving increasing attention . Herein , we report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate ( TRAMP ) mouse model . Male TRAMP mice , 8 wk old , were fed 0.1% , 0.3% , or 1% mixed tocotrienols i... | [
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] | 20661828 |
Many viruses subvert the host cell's ability to mount and complete various DNA damage responses ( DDRs ) after infection . HCMV infection of permissive fibroblasts activates host DDRs at the time of viral deposition and during replication , but the DDRs remain uncompleted without arrest or apoptosis . We believe this w... | [
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] | 23209410 |
Airway mucin secretion and MC ( mast cell ) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively . We found the exocytic protein Munc18b to be highly expressed in mouse airway epithelial cells and MCs , and localized to the apical pole of airway secretory cells . To addr... | [
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] | 22694344 |
Chromated copper arsenate , which is used worldwide as a wood preservative , can adversely affect human health . Accumulating evidence suggests that chromium ( Cr ) and arsenic ( As ) can potentially disrupt the redox balance and cause respiratory diseases and cancer in humans . The present study was designed to determ... | [
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0,
1
] | 19895865 |
The role of estrogen receptor beta ( ERβ ) in breast cancer is unclear . ERβ is considered to have a protective role in breast cancer development based on findings demonstrating that ERβ expression inhibits ERα-mediated proliferation of breast cancer cells . We previously demonstrated that ERβ causes a ligand independe... | [
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1,
0
] | 21120602 |
OBJECTIVE To investigate the effects of CdTe QDs ( cadmium telluride quantum dots ) on oxidative stress and DNA damage of liver cells in mice . METHODS Thirty ICR male mice were randomly divided into 5 groups : one negative control ( normal saline ) group . Three CdTe QDs groups ( exposed by intravenous injection of 0.... | [
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1,
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0,
1
] | 22443054 |
Identifying genomic alterations driving breast cancer is complicated by tumor diversity and genetic heterogeneity . Relevant mouse models are powerful for untangling this problem because such heterogeneity can be controlled . Inbred Chaos3 mice exhibit high levels of genomic instability leading to mammary tumors that h... | [
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0,
0
] | 22851646 |
Prohibiting angiogenesis is an important therapeutic approach for fighting cancer and other angiogenic related diseases . Research focused on proteins that regulate abnormal angiogenesis has attracted intense interest in both academia and industry . Such proteins are able to target several angiogenic factors concurrent... | [
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1,
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] | 23197380 |
The Alternative Lengthening of Telomeres ( ALT ) pathway is a telomerase-independent pathway for telomere maintenance that is active in a significant subset of human cancers and in vitro immortalized cell lines . ALT is thought to involve templated extension of telomeres through homologous recombination , but the genet... | [
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0,
0
] | 22829774 |
BACKGROUND AND AIMS breast reconstruction with silicone prosthesis following nipple-sparing mastectomy has become widely accepted as a reconstruction option in women requiring mastectomy for cancer . The purpose of this study was to evaluate the incidence and some factors influencing early local complications in patien... | [
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0,
0,
0,
0,
1,
0,
0
] | 21044925 |
Exposure of cells to UV light from the sun causes the formation of pyrimidine dimers in DNA that have the potential to lead to mutation and cancer . In humans , pyrimidine dimers are removed from the genome in the form of nt-long oligomers by concerted dual incisions . Though nearly 50 y of excision repair research has... | [
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0,
0
] | 22825251 |
We have recently proposed a new two-compartment model for understanding the Warburg effect in tumor metabolism . In this model , glycolytic stromal cells produce mitochondrial fuels ( L-lactate and ketone bodies ) that are then transferred to oxidative epithelial cancer cells , driving OXPHOS and mitochondrial metaboli... | [
1,
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1,
0,
0,
0,
0,
0,
0,
1
] | 22395432 |
A distinct group of breast cancers , called " basal " or " triple-negative " ( TN ) cancers express both basal cytokeratins and the epidermal growth factor receptor , but fail to express estrogen receptors , progesterone receptors or HER2 and have stem-like or mesenchymal features . They are particularly aggressive , a... | [
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1,
0,
0
] | 22189713 |
AIMS Currently , testing for mismatch repair deficiency in colorectal cancers is initiated by performing immunohistochemistry with four antibodies ( MLH1 , PMS2 , MSH2 and MSH6 ) . If any one of these stains is negative the tumour is considered microsatellite unstable and , if clinical circumstances warrant it , the pa... | [
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0,
0,
1,
0,
0,
0,
0
] | 20632815 |
Lipoprotein lipase ( LPL ) plays a central role in normal lipid metabolism as the key enzyme involved in the hydrolysis of triglycerides present in chylomicrons and very low density lipoproteins . LPL is a member of a family of hydrolytic enzymes that include hepatic lipase and pancreatic lipase . Based on primary sequ... | [
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1,
0,
0,
0,
0
] | 1371284 |
A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling . Computed tomography scans revealed a mass on the left lower lobe , pulmonary nodules , and pleural effusion . A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor ( EGFR ) deletion mutation , L74... | [
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1,
0,
0,
1,
0
] | 22835516 |
BACKGROUND Hepatocellular carcinoma ( HCC ) is the most common liver cancer . Therapeutic results are usually unsatisfactory because liver tumors recur often . Immunologic factors may be related to the recurrence of HCC ; however , this possibility is mentioned only rarely . METHODS Thirty HCC patients undergoing hepat... | [
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0,
0,
0,
1
] | 21975289 |
Topoisomerase inhibitors such as camptothecin and etoposide are used as anti-cancer drugs and induce double-strand breaks ( DSBs ) in genomic DNA in cycling cells . These DSBs are often covalently bound with polypeptides at the 3 ' and 5 ' ends . Such modifications must be eliminated before DSB repair can take place , ... | [
0,
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1,
0,
0,
0,
0
] | 20107609 |
Nonmelanoma skin cancer ( NMSC ) is by far the most frequent type of cancer in humans . NMSC includes several types of malignancies with different clinical outcomes , the most frequent being basal and squamous cell carcinomas . We have used the Sleeping Beauty transposon/transposase system to identify somatic mutations... | [
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0,
0,
1,
0,
0,
0,
0
] | 22832494 |
Pterostilbene , a polyphenolic compound present in grapes and other fruits , has been demonstrated to inhibit growth and induce apoptosis and autophagy in some cancer cell types . We found that pterostilbene at the IC90 concentration of 44 �M inhibited proliferation and induced apoptosis in MOLT4 human leukemia cells .... | [
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1,
0,
0,
1,
1,
0
] | 23264221 |
The innate immune response involves a variety of inflammatory reactions that can result in inflammatory disease and cancer if they are not resolved and instead are allowed to persist . The effective activation and resolution of innate immune responses relies on the production and posttranscriptional regulation of mRNAs... | [
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0,
0,
0,
1
] | 22201685 |
Therapy-induced cellular senescence ( TCS ) , characterized by prolonged cell cycle arrest , is an in vivo response of human cancers to chemotherapy and radiation . Unfortunately , TCS is reversible for a subset of senescent cells , leading to cellular reproliferation and ultimately tumor progression . This invariable ... | [
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1,
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] | 22945332 |
PURPOSE We describe the anticancer activity of ganetespib , a novel non-geldanamycin heat shock protein 90 ( HSP90 ) inhibitor , in non-small cell lung cancer ( NSCLC ) models . EXPERIMENTAL DESIGN The activity of ganetespib was compared with that of the geldanamycin 17-AAG in biochemical assays , cell lines , and xeno... | [
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0,
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0,
0,
0
] | 22806877 |
Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase ( MMP ) enzymes which facilitate invasion . Oleuropein , the main olive oil polyphenol , has anti-proliferative effects . This study aimed to investigate the effect of oleuropein on the metastatic and anti-metasta... | [
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] | 23167379 |
Modeling the behavior of mammalian arachnoid cells is critical to understand hydrocephalus and other brain disorders involving abnormal flow of cerebrospinal fluid , yet relatively little is known about the physiology of arachnoid cells due to lack of a robust three-dimensional model system . Explanted primary cultures... | [
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] | 21195136 |
Chromosomal translocations typically impair cell differentiation and often require secondary mutations for malignant transformation . However , the role of a primary translocation in the development of collaborating mutations is debatable . To delineate the role of leukemic translocation NUP98-HOXD13 ( NHD13 ) in secon... | [
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0
] | 23131583 |
The tumor suppressors Lats1 and Lats2 are mediators of the Hippo pathway that regulates tissue growth and proliferation . Their N-terminal non-kinase regions are distinct except for Lats conserved domains 1 and 2 ( LCD1 and LCD2 ) , which may be important for Lats1/2-specific functions . Lats1 knockout mice were genera... | [
0,
0,
0,
0,
1,
1,
0,
0,
1,
0
] | 23230145 |
The G protein-coupled human gastrin-releasing peptide receptor ( hGRP-R ) is frequently found aberrantly expressed in human cancers of the colon , stomach , and lung , and its ligand-specific activation has been implicated in cell proliferation and differentiation . Here , we demonstrated hGRP-R activation stimulated s... | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] | 12220644 |
Cardiac \u03b1-tropomyosin ( Tm ) single-site mutations D175N and E180G cause familial hypertrophic cardiomyopathy ( FHC ) . Previous studies have shown that these mutations increase both Ca(2+) sensitivity and residual contractile activity at low Ca(2+) concentrations , which causes incomplete relaxation during diasto... | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 22794249 |
The authors examined nutritional risk factors for prostate cancer among 9,559 participants in the Prostate Cancer Prevention Trial ( United States and Canada , 1994-2003 ) . The presence or absence of cancer was determined by prostate biopsy , which was recommended during the trial because of an elevated prostate-speci... | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1
] | 20693267 |
DNA double-strand breaks ( DSBs ) in embryonic stem ( ES ) cells are repaired primarily by homologous recombination ( HR ) . The mechanism by which HR is regulated in these cells , however , remains enigmatic . To gain insight into such regulatory mechanisms , we have asked how protein levels of Rad51 , a key component... | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 22705496 |
MDSCs and Tregs play an essential role in the immunosuppressive networks that contribute to tumor-immune evasion . The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-talk between MDSC and Treg remain incompletely defined . Previous reports have suggested that M... | [
0,
1,
0,
0,
0,
0,
0,
0,
1,
0
] | 22891289 |
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer . Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination , we have measured telomere length , telomerase activity and chromosome rearrangements in human cells before and after tr... | [
0,
0,
0,
1,
0,
0,
0,
0,
0,
0
] | 1582420 |
Ceramide induces cell cycle arrest and apoptotic cell death associated with increased levels of p27(kip1) . The aim of this study was to examine the effects of ceramide on p27(kip1) protein levels as a measure of cell cycle arrest and apoptosis . Results showed that ceramide increased p27(kip1) protein levels through a... | [
0,
0,
0,
0,
1,
0,
0,
0,
1,
0
] | 20954073 |
Tumor invasion and metastasis are the primary causes of cancer patient mortality , underscoring the need for identification of novel genes and signaling pathways that mediate these prognosis-determining phenomena . To identify and characterize novel lung adenocarcinoma genes associated with lung cancer progression , we... | [
1,
0,
0,
0,
0,
0,
0,
0,
1,
0
] | 20217555 |
Steroid hormone receptors , including estrogen receptor-alpha ( ERalpha ) , are ligand-activated transcription factors , and hormone binding leads to depletion of receptor levels via preteasome-mediated degradation . NEDD8 ( neural precursor cell-expressed developmentally down-regulated ) is an ubiquitin-like protein e... | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] | 12554766 |
The mechanisms by which tumour cells metastasize and the role that cell polarity proteins play in this process are not well understood . We report that partitioning defective protein 3 ( Par3 ) is dysregulated in metastasis in human breast cancer , and is associated with a higher tumour grade and ErbB2-positive status ... | [
1,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 23263278 |
Pyruvate kinase M2 ( PKM2 ) is a key player in the Warburg effect of cancer cells . However , the mechanisms of regulating PKM2 are not fully elucidated . Here , we identified the protein-serine/threonine kinase PIM2 , a known oncogene , as a novel binding partner of PKM2 . The interaction between PIM2 and PKM2 was con... | [
0,
0,
1,
0,
0,
1,
0,
0,
0,
0
] | 24142698 |
Approximately 50% of human tumors have a mutation in TP53 . The pattern and spectra of TP53 mutations often differ between cancer types , perhaps due to different etiological factors . The Hupki ( human TP53 knock-in ) mouse embryo fibroblast ( HUF ) immortalization assay is useful for studying mutagenesis in the human... | [
0,
0,
0,
0,
0,
1,
0,
0,
0,
0
] | 22351035 |
SWAP-70 , a phosphatidylinositol trisphosphate ( PtdIns(3,4,5)P(3) ) binding protein , has been suggested to be involved in transformation of mouse embryo fibroblasts ( MEFs ) as well as membrane ruffling after growth factor stimulation of the cells . A mutant , SWAP-70-374 , was found to be able to bind to F-actin in ... | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0
] | 21152038 |
Extensive biochemical and structural analyses have been performed on the putative DNA repair proteins of hyperthermophilic archaea , in contrast to the few genetic analyses of the genes encoding these proteins . Accordingly , little is known about the repair pathways used by archaeal cells at high temperature . Here , ... | [
0,
0,
0,
0,
0,
1,
0,
0,
0,
0
] | 21178304 |
PRL induces quiescent Nb2 rat T-lymphoma cells to undergo mitogenesis . Upon PRL stimulation , the transcription factor interferon regulatory factor-1 ( IRF-1 ) is induced as a novel T-cell activation gene in Nb2 cells . Surprisingly , IRF-1 is expressed twice during a single PRL-induced growth cycle : first during the... | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] | 1491701 |
The cyclin-dependent kinase ( CDK ) inhibitor p21(Waf1/Cip1/Sdi1) was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence . Reactive oxygen species ( ROS ) , a byproduct of oxidative processes , can also induce an irreversible growth arrest sim... | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
1
] | 11980715 |
Epidermal growth factor receptor ( EGFR ) and human epidermal growth factor receptor 2 ( HER2 ) amplification occurs in over 30% of esophageal carcinomas . Combination therapies with EGFR and HER2-targeting agents and cytotoxic agents are considered a potential therapeutic option for esophageal cancer . We evaluated th... | [
0,
0,
0,
0,
0,
0,
0,
1,
1,
0
] | 22293713 |
BACKGROUND Neuroblastoma ( NBL ) is a common pediatric solid tumor , and outcomes for patients with advanced neuroblastoma remain poor despite extremely aggressive treatment . Chemotherapy resistance at relapse contributes heavily to treatment failure . The poor survival of patients with high-risk NBL prompted this inv... | [
0,
0,
0,
0,
1,
0,
0,
1,
1,
0
] | 22415601 |
Escherichia coli pol V ( UmuD'(2)C ) , the main translesion DNA polymerase , ensures continued nascent strand extension when the cellular replicase is blocked by unrepaired DNA lesions . Pol V is characterized by low sugar selectivity , which can be further reduced by a Y11A " steric-gate " substitution in UmuC that en... | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 23144626 |
The c-Jun NH(2)-terminal kinase ( JNK ) signaling cascade has been implicated in a wide range of diseases , including cancer . It is unclear how different JNK proteins contribute to human cancer . Here , we report that JNK2 is activated in more than 70% of human squamous cell carcinoma ( SCC ) samples and that inhibiti... | [
0,
0,
1,
1,
0,
0,
0,
0,
0,
0
] | 20354187 |
A persistent immune response to hepatitis viruses is a well-recognized risk factor for hepatocellular carcinoma . However , the molecular and cellular basis for the procarcinogenic potential of the immune response is not well defined . Here , using a unique animal model of chronic hepatitis that induces hepatocellular ... | [
0,
0,
0,
0,
0,
0,
0,
1,
0,
1
] | 12391022 |
Gadd45a , the first well-defined p53 downstream gene , can be induced by multiple DNA-damaging agents , which plays important roles in the control of cell cycle checkpoint , DNA repair process and signaling transduction . Our previous findings suggested that Gadd45a maintains cell-cell adhesion and cell contact inhibit... | [
1,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 22825327 |
The glutathione peroxidases , a family of selenocysteine-containing redox enzymes , play pivotal roles in balancing the signaling , immunomodulatory , and deleterious effects of reactive oxygen species ( ROS ) . The glutathione peroxidase GPX3 is the only extracellular member of this family , suggesting it may defend c... | [
0,
0,
0,
0,
0,
1,
0,
1,
0,
1
] | 23221387 |
The environmental arylamine mutagens are implicated in the etiology of various sporadic human cancers . Arylamine-modified dG lesions were studied in two fully paired 11-mer duplexes with a -G*CN- sequence context , in which G* is a C8-substituted dG adduct derived from fluorinated analogs of 4-aminobiphenyl ( FABP ) ,... | [
0,
0,
0,
0,
0,
1,
0,
0,
0,
0
] | 23180767 |
Carboxypeptidase M ( CPM ) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins . CPM is thought to be involved in inflammatory processes . This is corroborated by CPM-mediated trimming and modulation of inflammatory factors , and expression of the protease in inflammatory... | [
0,
0,
0,
0,
0,
0,
0,
1,
0,
0
] | 22479563 |
Cellular senescence is considered as a tumor suppressive mechanism . Recent evidence indicates however that senescent cells secrete various growth factors and cytokines , some of which may paradoxically promote cancer progression . This phenomenon termed senescence-associated secretory phenotype ( SASP ) must be inhibi... | [
1,
0,
0,
1,
0,
0,
0,
0,
0,
0
] | 23272224 |
To elucidate role of the three enzymes in hepatocarcinogenesis , hMTH1 , hOGG1 and hMYH , mRNA expression were examined by using RT/semi-quantitative real-time PCR and 8-O-HdG levels was studied by HPLC/ECD in HCC and non-tumorous liver tissue of 21 patients with hepatocellular carcinoma ( HCC ) . It was found that the... | [
0,
0,
0,
0,
0,
1,
0,
0,
0,
1
] | 12658805 |
The UT-7 cell line was established from a patient with a megakaryoblastic leukemia ( Komatsu et al , Cancer Res 51 : 341 , 1991 ) . Its proliferation is strictly dependent on the presence of hematopoietic growth factors including erythropoietin ( Epo ) , granulocyte-macrophage colony-stimulating factor ( GM-CSF ) , and... | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] | 1467515 |
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