id stringlengths 20 20 | year int64 2.01k 2.02k | title stringlengths 21 249 | sections stringlengths 4.88k 32.5k | headings stringclasses 217
values | abstract stringlengths 32 4.12k | summary stringlengths 227 2.45k | keywords stringlengths 7 1.31k ⌀ | toc nullclasses 267
values |
|---|---|---|---|---|---|---|---|---|
journal.pntd.0007649 | 2,019 | A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections | Despite a marked decrease of Zika virus ( ZIKV ) infection since late 2017 , the specter of congenital Zika syndrome ( CZS ) and its re-emergence in flavivirus-endemic regions highlight the need for sensitive and specific diagnostic tests 1–4 ., Similar to the laboratory diagnosis for other flaviviruses , detection of ... | Introduction, Methods, Results, Discussion | The explosive spread of Zika virus ( ZIKV ) and associated complications in flavivirus-endemic regions underscore the need for sensitive and specific serodiagnostic tests to distinguish ZIKV , dengue virus ( DENV ) and other flavivirus infections ., Compared with traditional envelope protein-based assays , several nons... | Although there was a decrease of Zika virus ( ZIKV ) infection since late 2017 , the specter of congenital Zika syndrome and its re-emergence in flavivirus-endemic regions emphasize the need for sensitive and specific serological tests to distinguish ZIKV , dengue virus ( DENV ) and other flaviviruses ., Compared with ... | dengue virus, medicine and health sciences, enzyme-linked immunoassays, immune physiology, pathology and laboratory medicine, pathogens, immunology, microbiology, viruses, rna viruses, antibodies, immunologic techniques, research and analysis methods, immune system proteins, serology, proteins, medical microbiology, mi... | null |
journal.pntd.0004831 | 2,016 | The Burden of Zoonoses in Kyrgyzstan: A Systematic Review | Zoonoses are diseases in humans , which are naturally transmissible directly or indirectly from vertebrate animals ., Of 1415 species of infectious organisms know to be human pathogens , 61% are zoonotic 1 ., The Food and Agriculture Organization of the United Nations ( FAO ) , the World Health Organization ( WHO ) and... | Introduction, Materials and Methods, Results, Discussion | Zoonotic disease ( ZD ) pose a serious threat to human health in low-income countries ., In these countries the human burden of disease is often underestimated due to insufficient monitoring because of insufficient funding ., Quantification of the impact of zoonoses helps in prioritizing healthcare needs ., Kyrgyzstan ... | Zoonoses are diseases transmitted from vertebrate animals to humans ., They can cause a variety of symptoms ranging from mild gastrointestinal complaints to debilitating illness and even death ., Especially in low-income countries where animals play an important role for many , the burden of these diseases can be subst... | medicine and health sciences, tropical diseases, parasitic diseases, salmonellosis, brucellosis, bacterial diseases, rabies, neglected tropical diseases, veterinary science, campylobacteriosis, echinococcosis, public and occupational health, infectious diseases, veterinary diseases, zoonoses, helminth infections, biolo... | null |
journal.pcbi.1000611 | 2,009 | Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns | To understand brain function , it is essential to study the collective electrical activity of neural circuits 1 ., This activity typically exhibits intriguing spatiotemporally organized patterns: they are commonly observed in multi-unit electrophysiological recording , EEG local field potential recording , MEG , optica... | Introduction, Discussion | Activity in neural circuits is spatiotemporally organized ., Its spatial organization consists of multiple , localized coherent patterns , or patchy clusters ., These patterns propagate across the circuits over time ., This type of collective behavior has ubiquitously been observed , both in spontaneous activity and ev... | The brain processes information with extraordinary efficiency , and can perform feats such as effortlessly recognizing objects from among thousands of possibilities within a fraction of a second ., This is accomplished because the brain represents and processes information in a distributed fashion and in a dynamical wa... | biophysics/theory and simulation, computational biology/computational neuroscience | null |
journal.pgen.0030147 | 2,007 | Adaptive Evolution of Conserved Noncoding Elements in Mammals | Phenotypic evolution proceeds both by changes in protein coding sequences and by changes in gene expression that determine when , where , and how much genes are expressed 1–3 ., Although recent genome-wide studies have begun the process of identifying genes that show signals of adaptive evolution in coding sequences 4 ... | Introduction, Results, Discussion, Methods, Supporting Information | Conserved noncoding elements ( CNCs ) are an abundant feature of vertebrate genomes ., Some CNCs have been shown to act as cis-regulatory modules , but the function of most CNCs remains unclear ., To study the evolution of CNCs , we have developed a statistical method called the “shared rates test” to identify CNCs tha... | Conservation of DNA sequences across evolutionary history is a highly informative signal for identifying regions with important biological functions ., In particular , conserved noncoding regions have been shown to be good candidates for containing regulatory elements that have roles in gene regulation ., Recent studie... | evolutionary biology, genetics and genomics, mammals, computational biology | null |
journal.pgen.1002236 | 2,011 | A Comprehensive Map of Mobile Element Insertion Polymorphisms in Humans | Retrotransposons are endogenous genomic sequences that copy and paste into locations throughout host genomes 1–3 ., Most mobile elements annotated in the human reference genome are remnants of ancient retrotransposition events and are no longer capable of active retrotransposition ., However , a fraction of mobile elem... | Introduction, Results, Discussion, Materials and Methods | As a consequence of the accumulation of insertion events over evolutionary time , mobile elements now comprise nearly half of the human genome ., The Alu , L1 , and SVA mobile element families are still duplicating , generating variation between individual genomes ., Mobile element insertions ( MEI ) have been identifi... | We embarked on this study to explore the 1000 Genomes Project ( 1000GP ) pilot dataset as a substrate for Mobile Element Insertion ( MEI ) discovery and analysis ., MEI is already well known as a significant component of genetic variation in the human population ., However the full extent and effects of MEI can only be... | functional genomics, genetic mutation, genome evolution, genome scans, neutral theory, population genetics, genome sequencing, mutation, genome analysis tools, genome databases, mutation types, mutation databases, genetic polymorphism, biology, genetics, genomics, computational biology, genetics and genomics, human gen... | null |
journal.pcbi.1006142 | 2,018 | Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets | More than half of drug candidates that advance beyond phase I clinical trials fail due to lack of efficacy 1 , 2 ., One possible explanation for these failures is sub-optimal target selection 3 ., Many factors must be considered when selecting a target for drug discovery 4 , 5 ., Intrinsic factors include the likelihoo... | Introduction, Results, Discussion, Conclusion, Methods | Target selection is the first and pivotal step in drug discovery ., An incorrect choice may not manifest itself for many years after hundreds of millions of research dollars have been spent ., We collected a set of 332 targets that succeeded or failed in phase III clinical trials , and explored whether Omic features de... | Drug discovery often begins with a hypothesis that changing the abundance or activity of a target—a biological molecule , usually a protein—will cure a disease or ameliorate its symptoms ., Whether a target hypothesis translates into a successful therapy depends in part on the characteristics of the target , but it is ... | medicine and health sciences, tissue proteins, phase iii clinical investigation, protein expression, clinical medicine, mathematics, artificial intelligence, pharmacology, molecular biology techniques, discrete mathematics, combinatorics, research and analysis methods, computer and information sciences, proteins, gene ... | null |
journal.pcbi.1005389 | 2,017 | "Bayesian phylogeography of influenza A/H3N2 for the 2014-15 season in the United States using three(...TRUNCATED) | "Bayesian phylogeography has emerged as a powerful approach to analyzing virus spread ., It utilizes(...TRUNCATED) | Introduction, Results, Discussion | "Ancestral state reconstructions in Bayesian phylogeography of virus pandemics have been improved by(...TRUNCATED) | "For the better part of the last decade , epidemiological researchers have employed a Bayesian frame(...TRUNCATED) | "biogeography, taxonomy, ecology and environmental sciences, medicine and health sciences, pathology(...TRUNCATED) | null |
journal.pgen.1004037 | 2,014 | Intrasubtype Reassortments Cause Adaptive Amino Acid Replacements in H3N2 Influenza Genes | "The genome of influenza A virus consists of 8 segments , each represented by an RNA molecule ., Coi(...TRUNCATED) | Introduction, Results, Discussion, Methods | "Reassortments and point mutations are two major contributors to diversity of Influenza A virus; how(...TRUNCATED) | "Influenza A is a rapidly evolving virus with genome composed of eight distinct RNA molecules called(...TRUNCATED) | "organismal evolution, genome evolution, population genetics, microbiology, parallel evolution, muta(...TRUNCATED) | null |
journal.pcbi.1000927 | 2,010 | "Synaptic Plasticity Controls Sensory Responses through Frequency-Dependent Gamma Oscillation Resona(...TRUNCATED) | "Synchronous oscillations 1–3 in neural networks are thought to be important to sensory and cognit(...TRUNCATED) | Introduction, Results, Discussion, Methods | "Synchronized gamma frequency oscillations in neural networks are thought to be important to sensory(...TRUNCATED) | "In the nervous system , a network of neurons shows interesting population activities ., One example(...TRUNCATED) | "neuroscience/theoretical neuroscience, biophysics/theory and simulation, computational biology/syst(...TRUNCATED) | null |
journal.pcbi.1002879 | 2,013 | An Integrative Model of Ion Regulation in Yeast | "A feature of fungal physiology is the ability to adapt successfully to a variety of environmental p(...TRUNCATED) | Introduction, Results, Discussion, Methods | "Yeast cells are able to tolerate and adapt to a variety of environmental stresses ., An essential a(...TRUNCATED) | "Ion regulation is fundamental to cell physiology ., The concentrations of monovalent ions , such as(...TRUNCATED) | systems biology, biochemical simulations, regulatory networks, biology, computational biology | null |
End of preview. Expand in Data Studio
README.md exists but content is empty.
- Downloads last month
- 3