siddharthtumre/jnlpba-split · Datasets at Hugging Face

id stringlengths 1 5	tokens list	ner_tags list
3702	[ "All-trans-retinoic", "acid", "(", "ATRA", ")", "is", "the", "drug", "of", "choice", "in", "the", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8514	[ "Taken", "together", ",", "these", "observations", "suggest", "that", "nontoxic", "concentrations", "of", "reactive", "metabolites", "of", "oxygen", "and", "nitrogen", "play", "an", "important", "role", "in", "regulating", "the", "expression", "of", "genes", "invo...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4765	[ "Herpesvirus", "saimiri", "immortalized", "gamma", "delta", "T", "cell", "line", "activated", "by", "IL-12", "." ]	[ 5, 6, 6, 6, 6, 6, 6, 6, 0, 0, 9, 0 ]
10946	[ "Epstein-Barr", "virus", "(", "EBV", ")", ",", "a", "human", "gamma-herpesvirus", ",", "can", "establish", "both", "nonproductive", "(", "latent", ")", "and", "productive", "(", "lytic", ")", "infections", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15400	[ "The", "inhibition", "of", "HIV", "infection", "in", "cells", "stably", "expressing", "a", "transdominant", "Rev", "protein", ",", "in", "the", "absence", "of", "any", "deleterious", "effect", "on", "T", "cell", "function", ",", "suggests", "that", "such", "...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
2270	[ "Some", "antioxidants", ",", "including", "butylated", "hydroxyanisole", "(", "BHA", ")", ",", "tetrahydropapaveroline", "(", "THP", ")", ",", "nordihydroguiauretic", "acid", ",", "and", "10", ",", "11-dihydroxyaporphine", "(", "DHA", ")", ",", "were", "found", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 10, 0, 0, 9, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, ...
7443	[ "In", "addition", ",", "blocking", "TNF", ",", "itself", "a", "positive", "regulator", "of", "NF-kappaB", ",", "with", "neutralizing", "antibodies", "renders", "the", "cells", "more", "susceptible", "to", "anti-Fas-mediated", "apoptosis", "." ]	[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12208	[ "By", "contrast", ",", "UAS1", "(", "-140", "to", "-87", ")", "was", "B", "cell", "specific", "and", "was", "the", "key", "determinant", "of", "the", "promoter", "'s", "increased", "activity", "in", "B", "cell", "lines", "." ]	[ 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
16389	[ "An", "age-related", "decrease", "in", "the", "number", "of", "GR", "was", "suggested", "between", "subjects", "younger", "than", "20", "years", "and", "elderly", "subjects", ";", "there", "was", "no", "apparent", "seasonal", "variation", "in", "GR", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
17456	[ "Receptor", "mutant", "subclones", "of", "CEM-C7", ",", "which", "are", "proven", "to", "be", "completely", "unresponsive", "to", "micromolar", "concentrations", "of", "dexamethasone", "when", "grown", "in", "serum-supplemented", "medium", ",", "become", "partially"...	[ 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11109	[ "The", "regulatory", "Tat", "protein", "of", "the", "human", "immunodeficiency", "virus", "type-1", "(", "HIV-1", ")", "is", "essential", "for", "viral", "replication", "and", "also", "shows", "pleiotropic", "activities", "on", "various", "cell", "functions", "....	[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14540	[ "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "is", "a", "transcriptional", "activator", "that", "binds", "to", "sequences", "in", "the", "interleukin-2", "(", "IL-2", ")", "promoter", "and", "is", "thought", "to", "be", "largely", ...	[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
9729	[ "The", "RAKFKQLLQ-specific", "CTL", "precursor", "frequencies", "in", "all", "5", "persons", "were", "at", "least", "as", "dominant", "as", "those", "observed", "with", "two", "other", "EBV-associated", ",", "HLA-B8-restricted", "latent", "epitopes", ",", "FLRGRAY...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0 ]
13776	[ "Ro", "09-2210", "was", "also", "able", "to", "block", "antigen-induced", "IL-2", "secretion", "with", "an", "IC50", "=", "30", "nM", ",", "but", "was", "considerably", "less", "potent", "at", "blocking", "Ca2+", "flux", "stimulated", "by", "anti-CD3", "trea...	[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
2169	[ "Their", "effects", "on", "the", "src-family", "tyrosine", "kinase", "genes", "were", "different", ":", "hck", "expression", "was", "similarly", "induced", "by", "these", "agents", "but", "lyn", "expression", "was", "stronger", "and", "more", "rapid", "after", ...	[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15283	[ "The", "presence", "of", "the", "sulfhydryl", "agent", "dithiothreitol", "did", "not", "affect", "results", "suggesting", "the", "absence", "of", "disulfide", "bridges", "in", "the", "steroid", "binding", "domain", "of", "the", "receptor", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]
12392	[ "First", ",", "a", "substantial", "number", "of", "cells", "can", "express", "class", "II", "molecules", "in", "the", "absence", "of", "CIITA", ",", "albeit", "at", "5-fold", "reduced", "levels", ",", "most", "notably", "dendritic", "cells", "in", "s.c.", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]
156	[ "Activation", "of", "the", "TAL1", "(", "or", "SCL", ")", "gene", ",", "originally", "identified", "through", "its", "involvement", "by", "a", "recurrent", "chromosomal", "translocation", ",", "is", "the", "most", "frequent", "molecular", "lesion", "recognized",...	[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13228	[ "The", "position", "of", "XIC/XIST", "in", "the", "reciprocal", "products", "of", "the", "translocation", "was", "determined", "by", "XIST-specific", "FISH", "and", "computer", "enhancement", "." ]	[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14982	[ "We", "have", "now", "examined", "expression", "of", "the", "mouse", "E2A", "gene", "at", "the", "protein", "level", "using", "polyclonal", "antisera", "directed", "against", "distinct", "portions", "of", "the", "E2A", "protein", "to", "probe", "blots", "of", ...	[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
4610	[ "This", "review", "summarizes", "data", "on", "specific", "regulation", "of", "promoters", "and", "enhancers", "by", "nuclear", "trans-acting", "factors", "in", "lymphocytes", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 9, 10, 10, 0, 7, 0 ]
10991	[ "We", "show", "for", "human", "Jurkat", "T", "leukemia", "cells", ",", "as", "well", "as", "human", "and", "mouse", "primary", "T", "lymphocytes", ",", "that", "this", "inhibitory", "effect", "is", "accompanied", "by", "an", "impaired", "nuclear", "transloca...	[ 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
5300	[ "In", "this", "study", "we", "present", "a", "deletion", "analysis", "of", "the", "N-terminal", "region", "of", "Oct-2a", "to", "determine", "the", "minimal", "repression", "domain", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 0 ]
12178	[ "In", "mobility", "shift", "assays", ",", "a", "nuclear", "factor", "from", "THP-1", "and", "U-937", "cells", "was", "identified", "that", "binds", "to", "several", "AP-2", "response", "elements", "within", "the", "B2", "promoter", ",", "but", "does", "not",...	[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0 ]
8414	[ "In", "contrast", ",", "overexpression", "of", "CREB", "inhibited", "GAL4", "-p65", "(", "286-551", ")", "-mediated", "transcription", "." ]	[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
844	[ "Our", "previous", "studies", "in", "human", "monocytes", "have", "demonstrated", "that", "interleukin", "(", "IL", ")", "-10", "inhibits", "lipopolysaccharide", "(", "LPS", ")", "-stimulated", "production", "of", "inflammatory", "cytokines", ",", "IL-1", "beta", ...	[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 9, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0 ]
6008	[ "Therefore", ",", "we", "investigated", "whether", "IVS1-10T", "--", ">", "C", "deleteriously", "affected", "BRCA1", "splicing", "or", "expression", ",", "and", "thereby", "inactivated", "the", "other", "BRCA1", "allele", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
2788	[ "DLCL", "represent", "a", "heterogeneous", "group", "of", "neoplasms", "which", "are", "treated", "homogeneously", "despite", "the", "fact", "that", "only", "50", "%", "of", "patients", "experience", "long-term", "disease-free", "survival", "(", "Schneider", "et",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17270	[ "Further", "results", ",", "in", "which", "beta-gal", "activity", "is", "correlated", "with", "NF-AT", "-binding", "activity", ",", "indicate", "that", "the", "concentration", "of", "NF-AT", "must", "exceed", "a", "critical", "threshold", "before", "transcription"...	[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6771	[ "1", ",", "25-Dihydroxyvitamin", "D3", "(", "1", ",", "25", "(", "OH", ")", "2D3", ")", "plays", "a", "major", "role", "in", "the", "stimulation", "of", "bone", "growth", ",", "mineralization", ",", "and", "intestinal", "calcium", "and", "phosphate", "ab...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5738	[ "We", "find", "that", "TCL1", "is", "expressed", "in", "the", "majority", "of", "AIDS", "IBLP", "tumors", "examined", "." ]	[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15522	[ "Danazol", "bound", "to", "these", "sites", "in", "high", "concentration", "(", "10", "(", "-6", ")", "M", ",", "clinical", "serum", "concentration", "during", "danazol", "therapy", ")", "and", "decreased", "the", "number", "of", "both", "sites", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14242	[ "The", "proximal", "element", "contains", "the", "sequence", "5'-GGCCAATGGG-3", "'", ",", "which", "closely", "resembles", "the", "consensus", "binding", "motif", "for", "the", "CCAAT-binding", "factor", "NF-Y", "(", "CBF", ",", "CP1", ",", "alpha", "CP1", ")"...	[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 9, 0, 9, 0, 9, 0, 9, 10, 0, 0 ]
15119	[ "Both", "canrenone", "and", "cortisol", "were", "inactive", "as", "ligands", "up", "to", "concentrations", "of", "0.1", "microM", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15748	[ "Treatment", "of", "normal", "monocytes", "with", "12-0-tetradecanoyl", "phorbol-13-acetate", "(", "TPA", ")", "for", "4-24", "h", "caused", "the", "complete", "disappearance", "of", "NF", "kappa", "B", "from", "nuclear", "extracts", "of", "monocytes", "." ]	[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]
13067	[ "Interleukin", "2", "and", "15", "activate", "Stat3alpha", "in", "human", "T", "lymphocytes", "." ]	[ 9, 10, 10, 10, 0, 9, 0, 7, 8, 8, 0 ]
14774	[ "When", "co-transfected", "with", "a", "construct", "capable", "of", "overexpressing", "the", "tyrosine", "kinase", "p59fyn", ",", "the", "reporter", "gene", "was", "activated", "by", "PMA", "alone", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 1, 2, 0, 0, 0, 9, 0, 0 ]
5619	[ "In", "humans", ",", "there", "are", "two", "highly", "homologous", "genes", "encoding", "SCM-1alpha", "and", "SCM-1beta", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 9, 0 ]
2303	[ "In", "an", "effort", "to", "better", "understand", "the", "biology", "of", "this", "tumor", "additional", "immunohistochemical", "studies", "for", "the", "protein", "product", "of", "p53", "tumor", "suppressor", "gene", "and", "estrogen", "receptor", "expression"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 1, 2, 2, 2, 0, 9, 10, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
18424	[ "Because", "NF-kappa", "B", "activates", "many", "immunoregulatory", "genes", "in", "response", "to", "pro-inflammatory", "stimuli", ",", "the", "inhibition", "of", "its", "activity", "can", "be", "a", "major", "component", "of", "the", "anti-inflammatory", "activ...	[ 0, 9, 10, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
639	[ "The", "activity", "was", "determined", "to", "be", "distinct", "from", "TGF", ",", "TNF", ",", "and", "some", "commonly", "known", "lymphokines", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]
16446	[ "We", "describe", "a", "slide", "assay", "that", "allows", "the", "demonstration", "of", "antigens", "localized", "in", "the", "nucleus", "from", "isolated", "white", "blood", "cells", "as", "well", "as", "from", "single", "tumor", "cells", "derived", "from", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]
6840	[ "In", "previous", "work", ",", "we", "have", "shown", "that", "the", "parasite", "induces", "constitutive", "activation", "of", "the", "transcription", "factor", "NF-kappaB", ",", "by", "inducing", "the", "constitutive", "degradation", "of", "its", "cytoplasmic", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
17742	[ "Depending", "on", "costimulatory", "signals", ",", "SE", "induce", "either", "proliferation", "or", "anergy", "in", "T", "cells", "." ]	[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
5603	[ "Monocytes", "stimulated", "with", "LPS", "concentrations", "of", "1.0", "micrograms/ml", "displayed", "the", "above", "cytotoxic", "markers", ",", "whereas", "monocytes", "stimulated", "with", "DHEA", "alone", "or", "with", "LPS", "at", "a", "lower", "concentrati...	[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8012	[ "This", "factor", "also", "inhibited", "the", "synthesis", "of", "anti-DNP", "antibodies", "by", "a", "mouse", "hybridoma", "and", "diminished", "the", "proportion", "of", "cells", "in", "phase", "S", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4819	[ "PU.1", "(", "spi-1", ")", ",", "a", "member", "of", "the", "Ets", "transcription", "factor", "family", ",", "is", "predominantly", "expressed", "in", "myeloid", "and", "B", "cells", ",", "activates", "many", "B", "cell", "and", "myeloid", "genes", ",", ...	[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5136	[ "Inactivation", "of", "IkappaBbeta", "by", "the", "tax", "protein", "of", "human", "T-cell", "leukemia", "virus", "type", "1", ":", "a", "potential", "mechanism", "for", "constitutive", "induction", "of", "NF-kappaB", "." ]	[ 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
15060	[ "Previous", "cotransfection", "experiments", "had", "demonstrated", "that", "ectopic", "expression", "of", "the", "lymphocyte-specific", "transcription", "factor", "Oct2", "could", "efficiently", "activate", "a", "promoter", "containing", "an", "octamer", "motif", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]
13259	[ "Although", "the", "exact", "mechanism", "by", "which", "HTLV-I", "contributes", "to", "leukemogenesis", "is", "still", "unclear", ",", "the", "Tax", "protein", "is", "thought", "to", "play", "a", "major", "role", "in", "this", "process", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3857	[ "In", "addition", ",", "DNA", "methylation", "was", "revealed", "as", "one", "of", "the", "possible", "factors", "in", "establishing", "MNDA", "expression", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
499	[ "They", "also", "display", "constitutively", "high", "levels", "of", "p59fyn", "and", "CD3", "zeta", "tyrosine", "phosphorylation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0 ]
12426	[ "Here", ",", "we", "characterize", "the", "putative", "human", "homolog", "of", "NRL", ",", "neutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "." ]	[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0 ]
11803	[ "Cotransfection", "experiments", "revealed", "that", "both", "hGATA-4", "and", "PMA/A23187", "stimulation", "are", "necessary", "for", "the", "IL-5", "promoter", "activation", "." ]	[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
14030	[ "METHODS", ":", "Peripheral", "blood", "monocytes", "and", "T", "cells", "were", "prepared", "from", "patients", "with", "SLE", "(", "n", "=", "6", ")", "and", "healthy", "donors", "(", "n", "=", "8", ")", "." ]	[ 0, 0, 7, 8, 8, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14002	[ "We", "find", "that", "EKLF", "is", "an", "acetylated", "transcription", "factor", ",", "and", "that", "it", "interacts", "in", "vivo", "with", "CBP", ",", "p300", ",", "and", "P/CAF", "." ]	[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0 ]
18125	[ "Total", "RNA", "was", "isolated", "from", "peripheral", "blood", "mononuclear", "cells", "and", "hTR", "beta", "1", "mRNA", "levels", "determined", "by", "quantitative", "competitive", "reverse", "transcription", "PCR", "." ]	[ 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17786	[ "The", "genomic", "actions", "of", "1", ",", "25-dihydroxyvitamin", "D3", "(", "1", ",", "25", "(", "OH", ")", "2D3", ")", "are", "mediated", "by", "the", "intracellular", "vitamin", "D", "receptor", "(", "VDR", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
9522	[ "Using", "plasmids", "containing", "sense", "or", "antisense", "RXR-alpha", "sequences", "under", "the", "control", "of", "an", "inducible", "promoter", ",", "we", "generated", "stably", "transfected", "cell", "lines", "which", "expressed", "either", "increased", ...	[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
8824	[ "Tumor", "necrosis", "factor", "(", "TNF", ")", "-alpha", "-induced", "HIV-1", "replication", "in", "OM10.1", "or", "Ach2", "cells", "was", "significantly", "inhibited", "by", "non-cytotoxic", "doses", "of", "AuTG", "(", ">", "10", "microM", "in", "OM10.1", ...	[ 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
6468	[ "Direct", "interaction", "of", "hematopoietic", "transcription", "factors", "PU.1", "and", "GATA-1", ":", "functional", "antagonism", "in", "erythroid", "cells", "." ]	[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 0 ]
1641	[ "We", "now", "report", "the", "characterization", "of", "a", "second", "essential", "positive", "regulatory", "element", "located", "between", "nucleotides", "-137", "and", "-64", "that", "binds", "Elf-1", "and", "HMG-I", "(", "Y", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 9, 0, 9, 10, 10, 10, 0 ]
2095	[ "Furthermore", ",", "cyclosporin", "A", ",", "which", "blocked", "TNF", "alpha", "production", "induced", "by", "PKC", ",", "strongly", "inhibited", "IL-2R", "alpha", "and", "NF.kappa", "B", "activation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]
4387	[ "A", "principal", "objective", "of", "the", "present", "study", "was", "to", "identify", "more", "precisely", "similarities", "and", "divergences", "among", "lipopolysaccharide", "(", "LPS", ")", "-", "and", "lipoprotein-lipopeptide-induced", "immune", "cell", "sign...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13712	[ "In", "the", "first", "series", "we", "found", "that", "the", "number", "of", "glucocorticoid", "receptors", "and", "dissociation", "constant", "did", "not", "depend", "on", "the", "season", ",", "on", "the", "age", "of", "subjects", "nor", "on", "cortisol",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4768	[ "To", "date", ",", "a", "large", "number", "of", "receptors", "for", "IL-12", "have", "been", "found", "only", "on", "PBMC", "following", "activation", "with", "PHA", "or", "IL-2", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 0, 9, 0 ]
15614	[ "Inducibility", "of", "endogenous", "IFN-beta", "and", "IFN-alpha", "RNA", "was", "also", "increased", "in", "PLB-IIIB", "cells", "." ]	[ 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 5, 6, 0 ]
17853	[ "Cu2+", "was", "found", "to", "inhibit", "the", "activation", "of", "NF", "kappa", "B", "induced", "by", "TNF-alpha", ",", "TPA", ",", "or", "H2O2", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
5988	[ "Prior", "studies", "have", "shown", "MCP-1", "expression", "is", "modulated", "by", "a", "variety", "of", "ligands", "that", "act", "through", "extracellular", "receptors", "." ]	[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
15895	[ "Activation", "of", "ISGF3", "alpha", ",", "the", "latent", "component", "of", "ISGF3", ",", "occurs", "rapidly", "." ]	[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
7499	[ "In", "contrast", "to", "that", "reported", "for", "human", "Jurkat", "T", "cells", ",", "we", "found", "that", "p38", "MAPK", ",", "but", "not", "Jun", "NH2-terminal", "kinase", "(", "JNK", ")", ",", "is", "weakly", "activated", "upon", "stimulation", "...	[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 7, 8, 0, 7, 8, 8, 0 ]
18173	[ "Whereas", "TPCK", "inhibits", "phosphorylation", "of", "I", "kappa", "B", "and", ",", "consequently", ",", "activation", "of", "NF-kappa", "B", ",", "it", "markedly", "enhances", "the", "activity", "of", "JNK", ",", "the", "MAP", "kinase-related", "kinase", ...	[ 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 9, 0 ]
16853	[ "The", "effect", "of", "LPS", "on", "HIV-1", "replication", "occurs", "at", "picogram", "per", "milliliter", "concentrations", "and", "may", "be", "clinically", "significant", "in", "understanding", "the", "variability", "of", "the", "natural", "history", "of", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3651	[ "Severe", "combined", "immunodeficiency", "due", "to", "defective", "binding", "of", "the", "nuclear", "factor", "of", "activated", "T", "cells", "in", "T", "lymphocytes", "of", "two", "male", "siblings", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 7, 8, 0, 0, 0, 0, 0 ]
6403	[ "In", "addition", ",", "we", "evaluated", "the", "effect", "of", "dexamethasone", "on", "phorbolmyristate-acetate-stimulated", "IL-1", "receptor", "antagonist", "secretion", "by", "the", "human", "monocytic", "cell", "line", "U937", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
12086	[ "Using", "electrophoretic", "mobility", "shift", "analysis", "we", "demonstrated", "that", "the", "promoter", "region", "spanning", "base", "pairs", "-1", "to", "-275", ",", "which", "contains", "several", "putative", "binding", "sites", "for", "transcription", "f...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 0, 0, 9, 0 ]
15062	[ "We", "have", "tested", "a", "variety", "of", "Oct2", "isoforms", "generated", "by", "alternative", "splicing", "for", "the", "capability", "to", "activate", "an", "octamer", "enhancer", "in", "nonlymphoid", "cells", "and", "a", "B-cell", "line", "." ]	[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0, 5, 6, 0 ]
7358	[ "These", "results", "offer", "insight", "into", "a", "new", "role", "for", "NF-kappaB", "in", "maintaining", "survival", "and", "function", "in", "hematopoietic", "stem", "and", "progenitor", "cells", "and", "suggest", "that", "proposed", "strategies", "involving"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14096	[ "TCF/LEF", "proteins", "have", "recently", "been", "found", "to", "constitute", "a", "downstream", "component", "of", "the", "Wingless/Wnt", "signal", "transduction", "pathway", "." ]	[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5767	[ "The", "data", "imply", "that", "JAK", "/STAT", "signaling", "has", "a", "role", "in", "EBV-associated", "malignancies", "." ]	[ 0, 0, 0, 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
15633	[ "As", "a", "bioassay", "for", "glucocorticoid", "action", "we", "also", "measured", "dexamethasone", "suppressibility", "of", "mitogen-stimulated", "incorporation", "of", "[", "3H", "]", "thymidine", "in", "mononuclear", "leukocytes", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11786	[ "NFAT", "proteins", "constitute", "a", "family", "of", "transcription", "factors", "involved", "in", "mediating", "signal", "transduction", "." ]	[ 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
15343	[ "Both", "normal", "and", "malignant", "cells", "contain", "gangliosides", "as", "important", "cell", "membrane", "constituents", "that", ",", "after", "being", "shed", ",", "may", "influence", "cells", "of", "the", "immune", "system", "." ]	[ 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18302	[ "The", "effect", "of", "LPS", "and", "TNF-alpha", "is", "mediated", "by", "their", "ability", "to", "induce", "nuclear", "translocation", "of", "the", "DNA-binding", "heterodimer", "NF-kappa", "B", "(", "p50/p65", ")", ",", "which", "binds", "to", "a", "spec...	[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14078	[ "The", "implication", "of", "protein", "tyrosine", "kinase", "(", "s", ")", ",", "protein", "kinase", "A", "and/or", "protein", "kinase", "C", "was", "highlighted", "by", "the", "abrogation", "of", "the", "ManLAM-mediated", "activation", "of", "HIV-1", "LTR-dr...	[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]
5711	[ "Target", "structures", "of", "the", "CD8", "(", "+", ")", "-T-cell", "response", "to", "human", "cytomegalovirus", ":", "the", "72-kilodalton", "major", "immediate-early", "protein", "revisited", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0 ]
11282	[ "The", "ability", "of", "CMV", "IE", "gene", "products", "to", "enhance", "IL-6", "production", "may", "play", "an", "important", "role", "in", "immune", "inflammatory", "states", "associated", "with", "CMV", "infection", "." ]	[ 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11475	[ "Three", "mouse", "strains", "(", "C57BL/10SnJ", "[", "H-2b", "]", ",", "C3HeB/FeJ", "[", "H-2k", "]", ",", "and", "BALB/cByJ", "[", "H-2d", "]", ")", "were", "immunized", "with", "wild-type", "Ad", "or", "Ad", "vectors", "lacking", "the", "immunodominant"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
15082	[ "Differences", "in", "pre-", "and", "postoperative", "values", "of", "cancer", "patients", "were", "seen", "in", "plasma", "RIA", "values", ":", "PGE2", "and", "6-k-PGF1", "alpha", "were", "significantly", "higher", "preoperatively", "when", "compared", "with", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12257	[ "Co-transfection", "with", "dominant-negative", "mutant", "TNFRI", "inhibited", "EC", "activation", "by", "NK", "cell", "membrane", "extracts", "and", "by", "NK", "cells", "by", "80", "%", "and", "47", "%", ",", "respectively", "." ]	[ 0, 0, 9, 10, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5588	[ "Mechanisms", "that", "contribute", "to", "the", "development", "of", "lymphoid", "malignancies", ":", "roles", "for", "genetic", "alterations", "and", "cytokine", "production", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
572	[ "Twenty", "subjects", "matched", "for", "age", "and", "sex", "without", "known", "thyroid", "disease", "served", "as", "controls", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3851	[ "It", "is", "possible", "that", "the", "CRE", "site", "is", "responsible", "for", "induction", "of", "bcl-2", "expression", "in", "other", "cell", "types", ",", "particularly", "those", "in", "which", "protein", "kinase", "C", "is", "involved", "." ]	[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]
11205	[ "To", "extend", "these", "initial", "observations", ",", "we", "have", "examined", "the", "effect", "of", "antioxidant", "treatment", "on", "the", "activity", "of", "the", "mitogen-activated", "protein", "kinases", "erk1", "and", "erk2", ",", "as", "members", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5640	[ "[", "Hormonal", "metabolic", "status", "in", "breast", "cancer", "patients", "after", "conservative", "surgery", ":", "comparison", "with", "known", "prognostic", "criteria", "]" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9547	[ "Tissue", "transglutaminase-dependent", "posttranslational", "modification", "of", "the", "retinoblastoma", "gene", "product", "in", "promonocytic", "cells", "undergoing", "apoptosis", "." ]	[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 5, 6, 0, 0, 0 ]
15840	[ "In", "nonerythroid", "HL-60", "cells", "in", "which", "the", "HS2", "enhancer", "is", "inactive", ",", "long", "enhancer", "transcripts", "are", "not", "detectable", "." ]	[ 0, 5, 6, 6, 0, 0, 0, 1, 2, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0 ]
1779	[ "NF-kappa", "B", "was", "not", "activated", "by", "retinoic", "acid", ",", "which", "induced", "morphological", "differentiation", "of", "all", "the", "neuroblastoma", "cell", "lines", "used", "in", "the", "present", "study", "." ]	[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0 ]
10529	[ "IFN-gamma", "signaling", "is", "mediated", "by", "homodimeric", "STAT1", "protein", "." ]	[ 9, 0, 0, 0, 0, 9, 10, 10, 0 ]
1325	[ "These", "initial", "pathways", "culminate", "in", "a", "common", "pathway", "through", "which", "all", "of", "the", "stimulating", "agents", "ultimately", "signal", "NF-kappa", "B", "activation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

3702

[ "All-trans-retinoic", "acid", "(", "ATRA", ")", "is", "the", "drug", "of", "choice", "in", "the", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

8514

[ "Taken", "together", ",", "these", "observations", "suggest", "that", "nontoxic", "concentrations", "of", "reactive", "metabolites", "of", "oxygen", "and", "nitrogen", "play", "an", "important", "role", "in", "regulating", "the", "expression", "of", "genes", "invo...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

4765

[ "Herpesvirus", "saimiri", "immortalized", "gamma", "delta", "T", "cell", "line", "activated", "by", "IL-12", "." ]

[ 5, 6, 6, 6, 6, 6, 6, 6, 0, 0, 9, 0 ]

10946

[ "Epstein-Barr", "virus", "(", "EBV", ")", ",", "a", "human", "gamma-herpesvirus", ",", "can", "establish", "both", "nonproductive", "(", "latent", ")", "and", "productive", "(", "lytic", ")", "infections", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

15400

[ "The", "inhibition", "of", "HIV", "infection", "in", "cells", "stably", "expressing", "a", "transdominant", "Rev", "protein", ",", "in", "the", "absence", "of", "any", "deleterious", "effect", "on", "T", "cell", "function", ",", "suggests", "that", "such", "...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]

2270

[ "Some", "antioxidants", ",", "including", "butylated", "hydroxyanisole", "(", "BHA", ")", ",", "tetrahydropapaveroline", "(", "THP", ")", ",", "nordihydroguiauretic", "acid", ",", "and", "10", ",", "11-dihydroxyaporphine", "(", "DHA", ")", ",", "were", "found", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 10, 0, 0, 9, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, ...

7443

[ "In", "addition", ",", "blocking", "TNF", ",", "itself", "a", "positive", "regulator", "of", "NF-kappaB", ",", "with", "neutralizing", "antibodies", "renders", "the", "cells", "more", "susceptible", "to", "anti-Fas-mediated", "apoptosis", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

12208

[ "By", "contrast", ",", "UAS1", "(", "-140", "to", "-87", ")", "was", "B", "cell", "specific", "and", "was", "the", "key", "determinant", "of", "the", "promoter", "'s", "increased", "activity", "in", "B", "cell", "lines", "." ]

[ 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

16389

[ "An", "age-related", "decrease", "in", "the", "number", "of", "GR", "was", "suggested", "between", "subjects", "younger", "than", "20", "years", "and", "elderly", "subjects", ";", "there", "was", "no", "apparent", "seasonal", "variation", "in", "GR", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

17456

[ "Receptor", "mutant", "subclones", "of", "CEM-C7", ",", "which", "are", "proven", "to", "be", "completely", "unresponsive", "to", "micromolar", "concentrations", "of", "dexamethasone", "when", "grown", "in", "serum-supplemented", "medium", ",", "become", "partially"...

[ 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

11109

[ "The", "regulatory", "Tat", "protein", "of", "the", "human", "immunodeficiency", "virus", "type-1", "(", "HIV-1", ")", "is", "essential", "for", "viral", "replication", "and", "also", "shows", "pleiotropic", "activities", "on", "various", "cell", "functions", "....

[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

14540

[ "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "is", "a", "transcriptional", "activator", "that", "binds", "to", "sequences", "in", "the", "interleukin-2", "(", "IL-2", ")", "promoter", "and", "is", "thought", "to", "be", "largely", ...

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

9729

[ "The", "RAKFKQLLQ-specific", "CTL", "precursor", "frequencies", "in", "all", "5", "persons", "were", "at", "least", "as", "dominant", "as", "those", "observed", "with", "two", "other", "EBV-associated", ",", "HLA-B8-restricted", "latent", "epitopes", ",", "FLRGRAY...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0 ]

13776

[ "Ro", "09-2210", "was", "also", "able", "to", "block", "antigen-induced", "IL-2", "secretion", "with", "an", "IC50", "=", "30", "nM", ",", "but", "was", "considerably", "less", "potent", "at", "blocking", "Ca2+", "flux", "stimulated", "by", "anti-CD3", "trea...

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

2169

[ "Their", "effects", "on", "the", "src-family", "tyrosine", "kinase", "genes", "were", "different", ":", "hck", "expression", "was", "similarly", "induced", "by", "these", "agents", "but", "lyn", "expression", "was", "stronger", "and", "more", "rapid", "after", ...

[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

15283

[ "The", "presence", "of", "the", "sulfhydryl", "agent", "dithiothreitol", "did", "not", "affect", "results", "suggesting", "the", "absence", "of", "disulfide", "bridges", "in", "the", "steroid", "binding", "domain", "of", "the", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]

12392

[ "First", ",", "a", "substantial", "number", "of", "cells", "can", "express", "class", "II", "molecules", "in", "the", "absence", "of", "CIITA", ",", "albeit", "at", "5-fold", "reduced", "levels", ",", "most", "notably", "dendritic", "cells", "in", "s.c.", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]

156

[ "Activation", "of", "the", "TAL1", "(", "or", "SCL", ")", "gene", ",", "originally", "identified", "through", "its", "involvement", "by", "a", "recurrent", "chromosomal", "translocation", ",", "is", "the", "most", "frequent", "molecular", "lesion", "recognized",...

[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

13228

[ "The", "position", "of", "XIC/XIST", "in", "the", "reciprocal", "products", "of", "the", "translocation", "was", "determined", "by", "XIST-specific", "FISH", "and", "computer", "enhancement", "." ]

[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

14982

[ "We", "have", "now", "examined", "expression", "of", "the", "mouse", "E2A", "gene", "at", "the", "protein", "level", "using", "polyclonal", "antisera", "directed", "against", "distinct", "portions", "of", "the", "E2A", "protein", "to", "probe", "blots", "of", ...

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

4610

[ "This", "review", "summarizes", "data", "on", "specific", "regulation", "of", "promoters", "and", "enhancers", "by", "nuclear", "trans-acting", "factors", "in", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 9, 10, 10, 0, 7, 0 ]

10991

[ "We", "show", "for", "human", "Jurkat", "T", "leukemia", "cells", ",", "as", "well", "as", "human", "and", "mouse", "primary", "T", "lymphocytes", ",", "that", "this", "inhibitory", "effect", "is", "accompanied", "by", "an", "impaired", "nuclear", "transloca...

[ 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

5300

[ "In", "this", "study", "we", "present", "a", "deletion", "analysis", "of", "the", "N-terminal", "region", "of", "Oct-2a", "to", "determine", "the", "minimal", "repression", "domain", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 0 ]

12178

[ "In", "mobility", "shift", "assays", ",", "a", "nuclear", "factor", "from", "THP-1", "and", "U-937", "cells", "was", "identified", "that", "binds", "to", "several", "AP-2", "response", "elements", "within", "the", "B2", "promoter", ",", "but", "does", "not",...

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0 ]

8414

[ "In", "contrast", ",", "overexpression", "of", "CREB", "inhibited", "GAL4", "-p65", "(", "286-551", ")", "-mediated", "transcription", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

844

[ "Our", "previous", "studies", "in", "human", "monocytes", "have", "demonstrated", "that", "interleukin", "(", "IL", ")", "-10", "inhibits", "lipopolysaccharide", "(", "LPS", ")", "-stimulated", "production", "of", "inflammatory", "cytokines", ",", "IL-1", "beta", ...

[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 9, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0 ]

6008

[ "Therefore", ",", "we", "investigated", "whether", "IVS1-10T", "--", ">", "C", "deleteriously", "affected", "BRCA1", "splicing", "or", "expression", ",", "and", "thereby", "inactivated", "the", "other", "BRCA1", "allele", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

2788

[ "DLCL", "represent", "a", "heterogeneous", "group", "of", "neoplasms", "which", "are", "treated", "homogeneously", "despite", "the", "fact", "that", "only", "50", "%", "of", "patients", "experience", "long-term", "disease-free", "survival", "(", "Schneider", "et",...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

17270

[ "Further", "results", ",", "in", "which", "beta-gal", "activity", "is", "correlated", "with", "NF-AT", "-binding", "activity", ",", "indicate", "that", "the", "concentration", "of", "NF-AT", "must", "exceed", "a", "critical", "threshold", "before", "transcription"...

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

6771

[ "1", ",", "25-Dihydroxyvitamin", "D3", "(", "1", ",", "25", "(", "OH", ")", "2D3", ")", "plays", "a", "major", "role", "in", "the", "stimulation", "of", "bone", "growth", ",", "mineralization", ",", "and", "intestinal", "calcium", "and", "phosphate", "ab...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

5738

[ "We", "find", "that", "TCL1", "is", "expressed", "in", "the", "majority", "of", "AIDS", "IBLP", "tumors", "examined", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

15522

[ "Danazol", "bound", "to", "these", "sites", "in", "high", "concentration", "(", "10", "(", "-6", ")", "M", ",", "clinical", "serum", "concentration", "during", "danazol", "therapy", ")", "and", "decreased", "the", "number", "of", "both", "sites", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

14242

[ "The", "proximal", "element", "contains", "the", "sequence", "5'-GGCCAATGGG-3", "'", ",", "which", "closely", "resembles", "the", "consensus", "binding", "motif", "for", "the", "CCAAT-binding", "factor", "NF-Y", "(", "CBF", ",", "CP1", ",", "alpha", "CP1", ")"...

[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 9, 0, 9, 0, 9, 0, 9, 10, 0, 0 ]

15119

[ "Both", "canrenone", "and", "cortisol", "were", "inactive", "as", "ligands", "up", "to", "concentrations", "of", "0.1", "microM", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

15748

[ "Treatment", "of", "normal", "monocytes", "with", "12-0-tetradecanoyl", "phorbol-13-acetate", "(", "TPA", ")", "for", "4-24", "h", "caused", "the", "complete", "disappearance", "of", "NF", "kappa", "B", "from", "nuclear", "extracts", "of", "monocytes", "." ]

[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]

13067

[ "Interleukin", "2", "and", "15", "activate", "Stat3alpha", "in", "human", "T", "lymphocytes", "." ]

[ 9, 10, 10, 10, 0, 9, 0, 7, 8, 8, 0 ]

14774

[ "When", "co-transfected", "with", "a", "construct", "capable", "of", "overexpressing", "the", "tyrosine", "kinase", "p59fyn", ",", "the", "reporter", "gene", "was", "activated", "by", "PMA", "alone", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 1, 2, 0, 0, 0, 9, 0, 0 ]

5619

[ "In", "humans", ",", "there", "are", "two", "highly", "homologous", "genes", "encoding", "SCM-1alpha", "and", "SCM-1beta", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 9, 0 ]

2303

[ "In", "an", "effort", "to", "better", "understand", "the", "biology", "of", "this", "tumor", "additional", "immunohistochemical", "studies", "for", "the", "protein", "product", "of", "p53", "tumor", "suppressor", "gene", "and", "estrogen", "receptor", "expression"...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 1, 2, 2, 2, 0, 9, 10, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]

18424

[ "Because", "NF-kappa", "B", "activates", "many", "immunoregulatory", "genes", "in", "response", "to", "pro-inflammatory", "stimuli", ",", "the", "inhibition", "of", "its", "activity", "can", "be", "a", "major", "component", "of", "the", "anti-inflammatory", "activ...

[ 0, 9, 10, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

639

[ "The", "activity", "was", "determined", "to", "be", "distinct", "from", "TGF", ",", "TNF", ",", "and", "some", "commonly", "known", "lymphokines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]

16446

[ "We", "describe", "a", "slide", "assay", "that", "allows", "the", "demonstration", "of", "antigens", "localized", "in", "the", "nucleus", "from", "isolated", "white", "blood", "cells", "as", "well", "as", "from", "single", "tumor", "cells", "derived", "from", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]

6840

[ "In", "previous", "work", ",", "we", "have", "shown", "that", "the", "parasite", "induces", "constitutive", "activation", "of", "the", "transcription", "factor", "NF-kappaB", ",", "by", "inducing", "the", "constitutive", "degradation", "of", "its", "cytoplasmic", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

17742

[ "Depending", "on", "costimulatory", "signals", ",", "SE", "induce", "either", "proliferation", "or", "anergy", "in", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

5603

[ "Monocytes", "stimulated", "with", "LPS", "concentrations", "of", "1.0", "micrograms/ml", "displayed", "the", "above", "cytotoxic", "markers", ",", "whereas", "monocytes", "stimulated", "with", "DHEA", "alone", "or", "with", "LPS", "at", "a", "lower", "concentrati...

[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

8012

[ "This", "factor", "also", "inhibited", "the", "synthesis", "of", "anti-DNP", "antibodies", "by", "a", "mouse", "hybridoma", "and", "diminished", "the", "proportion", "of", "cells", "in", "phase", "S", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

4819

[ "PU.1", "(", "spi-1", ")", ",", "a", "member", "of", "the", "Ets", "transcription", "factor", "family", ",", "is", "predominantly", "expressed", "in", "myeloid", "and", "B", "cells", ",", "activates", "many", "B", "cell", "and", "myeloid", "genes", ",", ...

[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

5136

[ "Inactivation", "of", "IkappaBbeta", "by", "the", "tax", "protein", "of", "human", "T-cell", "leukemia", "virus", "type", "1", ":", "a", "potential", "mechanism", "for", "constitutive", "induction", "of", "NF-kappaB", "." ]

[ 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

15060

[ "Previous", "cotransfection", "experiments", "had", "demonstrated", "that", "ectopic", "expression", "of", "the", "lymphocyte-specific", "transcription", "factor", "Oct2", "could", "efficiently", "activate", "a", "promoter", "containing", "an", "octamer", "motif", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]

13259

[ "Although", "the", "exact", "mechanism", "by", "which", "HTLV-I", "contributes", "to", "leukemogenesis", "is", "still", "unclear", ",", "the", "Tax", "protein", "is", "thought", "to", "play", "a", "major", "role", "in", "this", "process", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

3857

[ "In", "addition", ",", "DNA", "methylation", "was", "revealed", "as", "one", "of", "the", "possible", "factors", "in", "establishing", "MNDA", "expression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

499

[ "They", "also", "display", "constitutively", "high", "levels", "of", "p59fyn", "and", "CD3", "zeta", "tyrosine", "phosphorylation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0 ]

12426

[ "Here", ",", "we", "characterize", "the", "putative", "human", "homolog", "of", "NRL", ",", "neutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0 ]

11803

[ "Cotransfection", "experiments", "revealed", "that", "both", "hGATA-4", "and", "PMA/A23187", "stimulation", "are", "necessary", "for", "the", "IL-5", "promoter", "activation", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]

14030

[ "METHODS", ":", "Peripheral", "blood", "monocytes", "and", "T", "cells", "were", "prepared", "from", "patients", "with", "SLE", "(", "n", "=", "6", ")", "and", "healthy", "donors", "(", "n", "=", "8", ")", "." ]

[ 0, 0, 7, 8, 8, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

14002

[ "We", "find", "that", "EKLF", "is", "an", "acetylated", "transcription", "factor", ",", "and", "that", "it", "interacts", "in", "vivo", "with", "CBP", ",", "p300", ",", "and", "P/CAF", "." ]

[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0 ]

18125

[ "Total", "RNA", "was", "isolated", "from", "peripheral", "blood", "mononuclear", "cells", "and", "hTR", "beta", "1", "mRNA", "levels", "determined", "by", "quantitative", "competitive", "reverse", "transcription", "PCR", "." ]

[ 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

17786

[ "The", "genomic", "actions", "of", "1", ",", "25-dihydroxyvitamin", "D3", "(", "1", ",", "25", "(", "OH", ")", "2D3", ")", "are", "mediated", "by", "the", "intracellular", "vitamin", "D", "receptor", "(", "VDR", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]

9522

[ "Using", "plasmids", "containing", "sense", "or", "antisense", "RXR-alpha", "sequences", "under", "the", "control", "of", "an", "inducible", "promoter", ",", "we", "generated", "stably", "transfected", "cell", "lines", "which", "expressed", "either", "increased", ...

[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

8824

[ "Tumor", "necrosis", "factor", "(", "TNF", ")", "-alpha", "-induced", "HIV-1", "replication", "in", "OM10.1", "or", "Ach2", "cells", "was", "significantly", "inhibited", "by", "non-cytotoxic", "doses", "of", "AuTG", "(", ">", "10", "microM", "in", "OM10.1", ...

[ 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...

6468

[ "Direct", "interaction", "of", "hematopoietic", "transcription", "factors", "PU.1", "and", "GATA-1", ":", "functional", "antagonism", "in", "erythroid", "cells", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 0 ]

1641

[ "We", "now", "report", "the", "characterization", "of", "a", "second", "essential", "positive", "regulatory", "element", "located", "between", "nucleotides", "-137", "and", "-64", "that", "binds", "Elf-1", "and", "HMG-I", "(", "Y", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 9, 0, 9, 10, 10, 10, 0 ]

2095

[ "Furthermore", ",", "cyclosporin", "A", ",", "which", "blocked", "TNF", "alpha", "production", "induced", "by", "PKC", ",", "strongly", "inhibited", "IL-2R", "alpha", "and", "NF.kappa", "B", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]

4387

[ "A", "principal", "objective", "of", "the", "present", "study", "was", "to", "identify", "more", "precisely", "similarities", "and", "divergences", "among", "lipopolysaccharide", "(", "LPS", ")", "-", "and", "lipoprotein-lipopeptide-induced", "immune", "cell", "sign...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

13712

[ "In", "the", "first", "series", "we", "found", "that", "the", "number", "of", "glucocorticoid", "receptors", "and", "dissociation", "constant", "did", "not", "depend", "on", "the", "season", ",", "on", "the", "age", "of", "subjects", "nor", "on", "cortisol",...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

4768

[ "To", "date", ",", "a", "large", "number", "of", "receptors", "for", "IL-12", "have", "been", "found", "only", "on", "PBMC", "following", "activation", "with", "PHA", "or", "IL-2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 0, 9, 0 ]

15614

[ "Inducibility", "of", "endogenous", "IFN-beta", "and", "IFN-alpha", "RNA", "was", "also", "increased", "in", "PLB-IIIB", "cells", "." ]

[ 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 5, 6, 0 ]

17853

[ "Cu2+", "was", "found", "to", "inhibit", "the", "activation", "of", "NF", "kappa", "B", "induced", "by", "TNF-alpha", ",", "TPA", ",", "or", "H2O2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

5988

[ "Prior", "studies", "have", "shown", "MCP-1", "expression", "is", "modulated", "by", "a", "variety", "of", "ligands", "that", "act", "through", "extracellular", "receptors", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

15895

[ "Activation", "of", "ISGF3", "alpha", ",", "the", "latent", "component", "of", "ISGF3", ",", "occurs", "rapidly", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

7499

[ "In", "contrast", "to", "that", "reported", "for", "human", "Jurkat", "T", "cells", ",", "we", "found", "that", "p38", "MAPK", ",", "but", "not", "Jun", "NH2-terminal", "kinase", "(", "JNK", ")", ",", "is", "weakly", "activated", "upon", "stimulation", "...

[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 7, 8, 0, 7, 8, 8, 0 ]

18173

[ "Whereas", "TPCK", "inhibits", "phosphorylation", "of", "I", "kappa", "B", "and", ",", "consequently", ",", "activation", "of", "NF-kappa", "B", ",", "it", "markedly", "enhances", "the", "activity", "of", "JNK", ",", "the", "MAP", "kinase-related", "kinase", ...

[ 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 9, 0 ]

16853

[ "The", "effect", "of", "LPS", "on", "HIV-1", "replication", "occurs", "at", "picogram", "per", "milliliter", "concentrations", "and", "may", "be", "clinically", "significant", "in", "understanding", "the", "variability", "of", "the", "natural", "history", "of", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

3651

[ "Severe", "combined", "immunodeficiency", "due", "to", "defective", "binding", "of", "the", "nuclear", "factor", "of", "activated", "T", "cells", "in", "T", "lymphocytes", "of", "two", "male", "siblings", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 7, 8, 0, 0, 0, 0, 0 ]

6403

[ "In", "addition", ",", "we", "evaluated", "the", "effect", "of", "dexamethasone", "on", "phorbolmyristate-acetate-stimulated", "IL-1", "receptor", "antagonist", "secretion", "by", "the", "human", "monocytic", "cell", "line", "U937", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

12086

[ "Using", "electrophoretic", "mobility", "shift", "analysis", "we", "demonstrated", "that", "the", "promoter", "region", "spanning", "base", "pairs", "-1", "to", "-275", ",", "which", "contains", "several", "putative", "binding", "sites", "for", "transcription", "f...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 0, 0, 9, 0 ]

15062

[ "We", "have", "tested", "a", "variety", "of", "Oct2", "isoforms", "generated", "by", "alternative", "splicing", "for", "the", "capability", "to", "activate", "an", "octamer", "enhancer", "in", "nonlymphoid", "cells", "and", "a", "B-cell", "line", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0, 5, 6, 0 ]

7358

[ "These", "results", "offer", "insight", "into", "a", "new", "role", "for", "NF-kappaB", "in", "maintaining", "survival", "and", "function", "in", "hematopoietic", "stem", "and", "progenitor", "cells", "and", "suggest", "that", "proposed", "strategies", "involving"...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

14096

[ "TCF/LEF", "proteins", "have", "recently", "been", "found", "to", "constitute", "a", "downstream", "component", "of", "the", "Wingless/Wnt", "signal", "transduction", "pathway", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

5767

[ "The", "data", "imply", "that", "JAK", "/STAT", "signaling", "has", "a", "role", "in", "EBV-associated", "malignancies", "." ]

[ 0, 0, 0, 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

15633

[ "As", "a", "bioassay", "for", "glucocorticoid", "action", "we", "also", "measured", "dexamethasone", "suppressibility", "of", "mitogen-stimulated", "incorporation", "of", "[", "3H", "]", "thymidine", "in", "mononuclear", "leukocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

11786

[ "NFAT", "proteins", "constitute", "a", "family", "of", "transcription", "factors", "involved", "in", "mediating", "signal", "transduction", "." ]

[ 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

15343

[ "Both", "normal", "and", "malignant", "cells", "contain", "gangliosides", "as", "important", "cell", "membrane", "constituents", "that", ",", "after", "being", "shed", ",", "may", "influence", "cells", "of", "the", "immune", "system", "." ]

[ 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

18302

[ "The", "effect", "of", "LPS", "and", "TNF-alpha", "is", "mediated", "by", "their", "ability", "to", "induce", "nuclear", "translocation", "of", "the", "DNA-binding", "heterodimer", "NF-kappa", "B", "(", "p50/p65", ")", ",", "which", "binds", "to", "a", "spec...

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

14078

[ "The", "implication", "of", "protein", "tyrosine", "kinase", "(", "s", ")", ",", "protein", "kinase", "A", "and/or", "protein", "kinase", "C", "was", "highlighted", "by", "the", "abrogation", "of", "the", "ManLAM-mediated", "activation", "of", "HIV-1", "LTR-dr...

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]

5711

[ "Target", "structures", "of", "the", "CD8", "(", "+", ")", "-T-cell", "response", "to", "human", "cytomegalovirus", ":", "the", "72-kilodalton", "major", "immediate-early", "protein", "revisited", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0 ]

11282

[ "The", "ability", "of", "CMV", "IE", "gene", "products", "to", "enhance", "IL-6", "production", "may", "play", "an", "important", "role", "in", "immune", "inflammatory", "states", "associated", "with", "CMV", "infection", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

11475

[ "Three", "mouse", "strains", "(", "C57BL/10SnJ", "[", "H-2b", "]", ",", "C3HeB/FeJ", "[", "H-2k", "]", ",", "and", "BALB/cByJ", "[", "H-2d", "]", ")", "were", "immunized", "with", "wild-type", "Ad", "or", "Ad", "vectors", "lacking", "the", "immunodominant"...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]

15082

[ "Differences", "in", "pre-", "and", "postoperative", "values", "of", "cancer", "patients", "were", "seen", "in", "plasma", "RIA", "values", ":", "PGE2", "and", "6-k-PGF1", "alpha", "were", "significantly", "higher", "preoperatively", "when", "compared", "with", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

12257

[ "Co-transfection", "with", "dominant-negative", "mutant", "TNFRI", "inhibited", "EC", "activation", "by", "NK", "cell", "membrane", "extracts", "and", "by", "NK", "cells", "by", "80", "%", "and", "47", "%", ",", "respectively", "." ]

[ 0, 0, 9, 10, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

5588

[ "Mechanisms", "that", "contribute", "to", "the", "development", "of", "lymphoid", "malignancies", ":", "roles", "for", "genetic", "alterations", "and", "cytokine", "production", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

572

[ "Twenty", "subjects", "matched", "for", "age", "and", "sex", "without", "known", "thyroid", "disease", "served", "as", "controls", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

3851

[ "It", "is", "possible", "that", "the", "CRE", "site", "is", "responsible", "for", "induction", "of", "bcl-2", "expression", "in", "other", "cell", "types", ",", "particularly", "those", "in", "which", "protein", "kinase", "C", "is", "involved", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]

11205

[ "To", "extend", "these", "initial", "observations", ",", "we", "have", "examined", "the", "effect", "of", "antioxidant", "treatment", "on", "the", "activity", "of", "the", "mitogen-activated", "protein", "kinases", "erk1", "and", "erk2", ",", "as", "members", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

5640

[ "[", "Hormonal", "metabolic", "status", "in", "breast", "cancer", "patients", "after", "conservative", "surgery", ":", "comparison", "with", "known", "prognostic", "criteria", "]" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

9547

[ "Tissue", "transglutaminase-dependent", "posttranslational", "modification", "of", "the", "retinoblastoma", "gene", "product", "in", "promonocytic", "cells", "undergoing", "apoptosis", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 5, 6, 0, 0, 0 ]

15840

[ "In", "nonerythroid", "HL-60", "cells", "in", "which", "the", "HS2", "enhancer", "is", "inactive", ",", "long", "enhancer", "transcripts", "are", "not", "detectable", "." ]

[ 0, 5, 6, 6, 0, 0, 0, 1, 2, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0 ]

1779

[ "NF-kappa", "B", "was", "not", "activated", "by", "retinoic", "acid", ",", "which", "induced", "morphological", "differentiation", "of", "all", "the", "neuroblastoma", "cell", "lines", "used", "in", "the", "present", "study", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0 ]

10529

[ "IFN-gamma", "signaling", "is", "mediated", "by", "homodimeric", "STAT1", "protein", "." ]

[ 9, 0, 0, 0, 0, 9, 10, 10, 0 ]

1325

[ "These", "initial", "pathways", "culminate", "in", "a", "common", "pathway", "through", "which", "all", "of", "the", "stimulating", "agents", "ultimately", "signal", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]