Datasets:
siddharthtumre
/
Revised-JNLPBA

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6401
[ "To", "accomplish", "this", ",", "we", "first", "analyzed", "the", "pattern", "of", "TNFalpha", "and", "IL-10", "inhibition", "by", "dexamethasone", "in", "LPS-stimulated", "whole-blood", "cell", "cultures", "." ]
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6402
[ "Second", ",", "we", "studied", "the", "modulation", "of", "the", "sensitivity", "of", "these", "cells", "to", "dexamethasone", "by", "preincubation", "with", "TNFalpha", "or", "IL-10", "and", "measurement", "of", "LPS-stimulated", "IL-6", "secretion", "." ]
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6403
[ "In", "addition", ",", "we", "evaluated", "the", "effect", "of", "dexamethasone", "on", "phorbolmyristate-acetate-stimulated", "IL-1", "receptor", "antagonist", "secretion", "by", "the", "human", "monocytic", "cell", "line", "U937", "." ]
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6404
[ "Finally", ",", "we", "investigated", "whether", "the", "modulation", "of", "corticosensitivity", "in", "TNFalpha-", "and", "IL-10-pretreated", "U937", "cells", "was", "related", "to", "a", "change", "of", "the", "glucocorticoid", "receptor", "concentration", "and",...
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6405
[ "Dexamethasone", "had", "different", "effects", "on", "LPS-induced", "TNFalpha", "and", "IL-10", "secretion", ";", "whereas", "it", "suppressed", "TNFalpha", "in", "a", "dose-dependent", "fashion", ",", "its", "effect", "on", "IL-10", "secretion", "was", "biphasic...
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6406
[ "The", "concentration", "of", "LPS", "employed", "influenced", "the", "effect", "of", "dexamethasone", "on", "IL-10", "secretion", "(", "P", "<", "0.001", ")", "." ]
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6407
[ "Pretreatment", "with", "TNFalpha", "diminished", ",", "and", "with", "IL-10", "improved", ",", "the", "ability", "of", "dexamethasone", "to", "suppress", "IL-6", "secretion", "in", "whole-blood", "cell", "cultures", "(", "P", "<", "0.01", "for", "both", ")", ...
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6408
[ "TNFalpha", "decreased", "(", "P", "<", "0.001", ")", ",", "while", "IL-10", "increased", "(", "P", "<", "0.001", ")", ",", "the", "concentration", "of", "dexamethasone", "binding", "sites", "in", "these", "cells", ",", "with", "no", "discernible", "effect...
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6409
[ "We", "conclude", "that", "glucocorticoids", "differentially", "modulate", "TNFalpha", "and", "IL-10", "secretion", "by", "human", "monocytes", "in", "a", "LPS", "dose-dependent", "fashion", "and", "that", "the", "sensitivity", "of", "these", "cells", "to", "gluco...
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6410
[ "This", "is", "accompanied", "by", "opposite", "glucocorticoid", "receptor", "changes", ",", "respectively", "opposing", "and", "favoring", "glucocorticoid", "actions", "." ]
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6411
[ "This", "study", "suggests", "that", "the", "pattern", "of", "pro-/antiinflammatory", "cytokine", "secretion", "may", "alter", "the", "response", "of", "patients", "to", "glucocorticoid", "therapy", "." ]
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6412
[ "Block", "of", "granulocytic", "differentiation", "of", "32Dcl3", "cells", "by", "AML1/ETO", "(", "MTG8", ")", "but", "not", "by", "highly", "expressed", "Bcl-2", "." ]
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6413
[ "The", "chimeric", "gene", ",", "AML1/ETO", "(", "MTG8", ")", ",", "generated", "in", "t", "(", "8", ";", "21", ")", "acute", "myeloid", "leukemia", "enhances", "the", "expression", "of", "Bcl-2", "." ]
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6414
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6415
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6416
[ "However", ",", "even", "the", "cells", "expressing", "very", "high", "levels", "of", "exogenous", "Bcl-2", "eventually", "underwent", "differentiation", "without", "a", "significant", "decrease", "in", "the", "synthesis", "of", "Bcl-2", "." ]
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6417
[ "On", "the", "contrary", ",", "32Dcl3", "cells", "stably", "expressing", "AML1/ETO", "were", "completely", "resistant", "to", "differentiation", "and", "continued", "to", "grow", "in", "the", "presence", "of", "G-CSF", "." ]
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6418
[ "These", "results", "are", "consistent", "with", "the", "interpretation", "that", "stimulation", "of", "Bcl-2", "expression", "is", "not", "the", "primary", "target", "of", "AML1/ETO", "." ]
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6419
[ "Host", "defense", "mechanisms", "triggered", "by", "microbial", "lipoproteins", "through", "toll-like", "receptors", "." ]
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6420
[ "The", "generation", "of", "cell-mediated", "immunity", "against", "many", "infectious", "pathogens", "involves", "the", "production", "of", "interleukin-12", "(", "IL-12", ")", ",", "a", "key", "signal", "of", "the", "innate", "immune", "system", "." ]
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6421
[ "Yet", ",", "for", "many", "pathogens", ",", "the", "molecules", "that", "induce", "IL-12", "production", "by", "macrophages", "and", "the", "mechanisms", "by", "which", "they", "do", "so", "remain", "undefined", "." ]
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6422
[ "Here", "it", "is", "shown", "that", "microbial", "lipoproteins", "are", "potent", "stimulators", "of", "IL-12", "production", "by", "human", "macrophages", ",", "and", "that", "induction", "is", "mediated", "by", "Toll-like", "receptors", "(", "TLRs", ")", "....
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6423
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6424
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6425
[ "Abnormal", "NF-kappa", "B", "activity", "in", "T", "lymphocytes", "from", "patients", "with", "systemic", "lupus", "erythematosus", "is", "associated", "with", "decreased", "p65-RelA", "protein", "expression", "." ]
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6426
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6427
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6428
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6429
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6430
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6431
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6432
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6433
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6434
[ "Finally", ",", "immunoblot", "analysis", "of", "nuclear", "extracts", "showed", "decreased", "or", "absent", "p65", "protein", "levels", "." ]
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6435
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6436
[ "Signaling", "events", "induced", "by", "lipopolysaccharide-activated", "toll-like", "receptor", "2", "." ]
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6437
[ "Human", "Toll-like", "receptor", "2", "(", "TLR2", ")", "is", "a", "signaling", "receptor", "that", "responds", "to", "LPS", "and", "activates", "NF-kappaB", "." ]
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6438
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6439
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6440
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6441
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6442
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6443
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6444
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6445
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6446
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6447
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6448
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6449
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6450
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6451
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6452
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6453
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6454
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6455
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6456
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6457
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6458
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