id
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7
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24
527
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2 classes
annotations
list
6519218_1
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"observed\"]], \"start\": [[93]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"chronic low-dosage amiodaro...
12126225_2
A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[18]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"A 75-year-old man\"]], \"sta...
10475726_1
An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[25]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"venlafaxine\"]], \"start\...
21751666_5
Oseltamivir was effective for post-exposure prophylaxis of H1N1 in close contact.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"post-exposure prophylaxis\"]], \"start\": [[30]], \"entity_id\": [\"T6\"]}, \"Treatment\...
19365885_1
Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[68]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"long-acting octreotide treatme...
25417855_1
Worsening pneumonitis due to a pharmacokinetic drug-drug interaction between everolimus and voriconazole in a renal transplant patient.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due to\"]], \"start\": [[22]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"a renal transplant patient\"]],...
11576059_1
Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"consequence\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Vocal cord paralysis\"]], \...
1267457_3
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.
false
[ { "events": [ { "event_id": "E2", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"drug-trigger\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"sulfonamides\"]], \"sta...
576675_2
Edema associated with ibuprofen therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Edema\"]], \"start\": [[0]], ...
3365032_1
A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[137]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A patient is presented with typ...
12243603_7
Atorvastatin is the most potent of this class of agents currently available and is commonly used in the treatment of hyperlipidemia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[104]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [...
2935070_2
However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[68]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"ampicillin\"]], \"start\": [[5...
2956288_3
Optic neuropathy in ethambutol-treated renal tuberculosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Optic neuropathy\"]], \"start\"...
7779233_2
This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[74]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"sodium warfarin\"]], \"start...
8384030_4
OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[50]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[21]],...
7673653_3
However, the occurrence and management of akathisia induced by fluvoxamine have not been described.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[52]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"akathisia\"]], \"start\": [[42]...
17009081_3
Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated with\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Nephrotic syndrome\"]],...
17438184_3
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[83]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A 48-year-old woman\"]], \"start...
4095247_3
Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"lost\"]], \"start\": [[75]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"Two of these patients\"]], \"star...
16986159_1
We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"mild parkinsonian signs and c...
7379406_3
The case report discussed is, to our knowledge, the third of its kind regarding bone fluorosis resulting from use of this nicotinic derivative.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"use\"]], \"start\": [[110]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"nicotinic derivative\"]], \"sta...
17266059_3
We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[90]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Thrombotic Thrombocytopenic Purpura\...
11144696_3
A 25-year-old white woman with chronic depression was treated with venlafaxine 150 mg/d and trimipramine 50 mg/d.
true
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[54]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"...
12078977_1
A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"A 31-year-old female\"]], \"...
8604715_1
Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"secondary\"]], \"start\": [[58]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"foscarnet\"]], \"start\": ...
16765687_1
PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Topiramate\"]], \"start\": [...
18344455_4
These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"managed\"]], \"start\": [[88]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"...
2728526_4
This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[48]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"rifampin\", \"after a fou...
6721543_1
Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[5]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"administration of quinacrine ...
10688731_3
We report a case of a scleroderma-like reaction induced by long-term administration of UFT.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[48]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"a scleroderma-like reaction\"]]...
16109609_4
We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[73]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"hemodynamically significant pericard...
10679548_1
Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"improved\"]], \"start\": [[93]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\...
18691992_6
OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[150]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"multiple squamous cell carc...
17319250_2
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[79]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"oral methadone\"]], \"start\...
19897274_3
In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[92]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a Japanese patient\"]], \"start...
15494638_17
Neurotoxicity occurs most often with intermittent high dose 5-FU as bolus injection or 24- to 48-h infusions.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurs\"]], \"start\": [[14]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Neurotoxicity\"]], \"start\": [[...
14998226_7
Lovastatin also reportedly has caused increases in INR when coadministered with warfarin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Lovastatin\"]], \"start\": [[...
14998226_10
Pravastatin does not appear to interact with warfarin but has caused an increased INR when combined with the anticoagulant fluindione.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[62]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"increased INR\"]], \"start\": [...
8120934_2
Bromocriptine-induced schizophrenia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[14]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Bromocriptine\"]], \"start\"...
17873198_2
Pulmonary toxicity associated with erlotinib.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Pulmonary toxicity\"]], \"st...
2442958_1
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[38]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Multicentric hepatocellular c...
16025424_1
Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"quetiapine\"]], \"start\": [...
3815268_1
A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"57-year-old woman\"]], \"sta...
9013348_2
Mesalamine-induced hypersensitivity pneumonitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Mesalamine\"]], \"start\": [...
11737689_2
A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[51]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"7 months after commencing ...
71813_3
Lichen planus and acne provoked by gold.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"provoked\"]], \"start\": [[23]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Lichen planus and acne\"]], \"...
12153007_2
To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"linked\"]], \"start\": [[70]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"AML\"]], \"start\": [[56]], \"en...
12656748_3
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[75]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"CML\"]], \"start\": [[71]], \"en...
10614572_1
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[22]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Intravenous valproate\"]]...
17876386_2
Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[19]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"moxifloxacin\"]], \"start...
25417855_3
We report serious adverse effects due to interaction between orally administered voriconazole and everolimus in a renal transplant recipient.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due to\"]], \"start\": [[34]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"serious adverse effects\"]], \"s...
2554727_1
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[58]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Horner's syndrome and demyelinat...
16097572_1
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[27]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"radiation myelopathy\"]], \"start...
8053440_4
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[74]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"ductopenia\"]], \"start\": [[52]...
7781845_1
Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[11]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"Mefloquine\"]], \"start\"...
19226083_17
Patients who commonly require linezolid as an antimicrobial are those with complex infections where other antibiotic treatment has failed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"require\"]], \"start\": [[22]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"Pa...
6245286_2
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[108]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"three of these patients\"]]...
17655517_9
Patients receiving linezolid for more than 28 days should be monitored for signs of peripheral and optic neuropathy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"monitored\"]], \"start\": [[61]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"linezolid for more than 2...
3941210_1
Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[47]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"amiodarone\"]], \"start\": [...
7249424_1
Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"association\"]], \"start\": [[106]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"Lithium\"]], \"start\"...
17509184_1
A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[124]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"40-year-old man with advanced H...
19892516_2
Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[14]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Ciprofloxacin\"]], \"start\"...
15028964_7
Given that significant thyroid disorders may be only mildly symptomatic and thus may escape clinical detection, we suggest that thyroid function should be tested in any patient with otherwise unexplained changes in warfarin dose requirements, particularly if concomitantly treated with amiodarone.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"changes\"]], \"start\": [[204]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"significant thyroid disorders\...
10367184_1
Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[9]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"pravastatin\"]], \"start\"...
7668127_5
This observation questions the suitability of aspirin as prophylaxis for vascular disease in patients with meningiomas.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"prophylaxis\"]], \"start\": [[57]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": ...
8360712_2
Delayed neurotoxicity of intraventricular interleukin-2: a case report.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"of\"]], \"start\": [[22]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Delayed neurotoxicity\"]], \"start\"...
7776854_4
We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"hepatotoxicity\", \"severe chroni...
3579660_3
We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"suffered\"]], \"start\": [[121]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a patient with Wilson's dise...
16889287_3
We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[51]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a 21-year-old female patient\"]],...
22233409_5
The adverse events related to ribavirin and drug-drug interactions during therapy for hepatitis C are discussed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[19]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"ribavirin\"]], \"start\": [[...
2309833_3
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[71]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"8 weeks after the initiation o...
417679_1
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[52]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"fat embolism\"]], \"start\": ...
18176653_1
Oral adverse effects due to the use of Nevirapine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[21]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Nevirapine\"]], \"start\": [[39]...
19299370_4
PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[39]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"enoxaparin\"]], \"start\": [...
15383642_9
Tizanidine was used again after her BP had stabilized, but did not produce similar problems.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"produce\"]], \"start\": [[67]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"Tizanidine\"]], \"start\": [...
424824_3
It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"inducing\"]], \"start\": [[86]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\"...
8816294_1
The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[27]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"delayed encephalopathy\"]], \...
3565435_2
Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[65]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"ibuprofen\", \"prolonged thera...
11250985_2
In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"lead\"]], \"start\": [[91]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"spironolactone\"]], \"start\": ...
10516999_2
We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"secondary\"]], \"start\": [[44]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"acute hyperphosphatemia\"]], ...
12365708_4
Visual changes secondary to initiation of amiodarone: a case report and review involving ocular management in cardiac polypharmacy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"secondary\"]], \"start\": [[15]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Visual changes\"]], \"start\"...
14674674_3
This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[75]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"lupus\"]], \"start\": [[83]], \...
17420198_19
A patient with developmental disabilities who had no history of movement disorders developed EPS following initiation of aripiprazole.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[97]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"EPS\"]], \"start\": [[93]], ...
15307435_1
Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[44]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"life-threatening hypoglycaem...
12811715_2
Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.
false
[ { "events": [ { "event_id": "E2", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[58]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"treat...
228648_1
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[125]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"Prenatal cytomegalovirus (CMV)...
20178709_2
Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"provoke\"]], \"start\": [[24]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Methotrexate\"]], \"start\":...
21597286_6
Prescription analyses by pharmacists and literature research have permitted us to suggest that a drug-drug interaction between methotrexate and proton pump inhibitors (PPI) was responsible for this renal failure.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"responsible\"]], \"start\": [[177]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"methotrexate and proton...
18795_2
Asthma and urticaria during disodium cromoglycate treatment.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Asthma and urticaria\"]], \"star...
10679548_7
We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[62]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"nitrofurantoin\"]], \"start\...
2369419_2
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"taking\"]], \"start\": [[107]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\":...
16116136_4
Primary CNS lymphoma regressed on withdrawal of MM.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"regressed\"]], \"start\": [[21]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[...
6498095_2
Pemphigus foliaceus induced by rifampicin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[20]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Pemphigus foliaceus\"]], \"star...
2931445_3
L-T4 stimulated lymphocyte transformation in this patient.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"stimulated\"]], \"start\": [[5]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"L-T4\"]], \"start\": [[0]]...
12126225_1
A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[52]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"A 53-year-old man\"]], \"start\"...
3143551_2
A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[149]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"valproate\"]], \"start\": [[...
12086549_1
After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[49]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"5 days of treatment with ...
9399776_1
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[19]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"Acute pancreatitis\"]], \"start\"...