Study_ID string | Objectives string | Included string | Excluded string |
|---|---|---|---|
CRD420250616527 | How do the metrics of heart rate variability (HRV), both in the time domain and frequency domain, vary in patients diagnosed with anorexia nervosa compared to healthy controls? Additionally, how are these variations related to the different stages of the disorder and to clinical outcomes, considering the measurement ti... | Anorexia nervosa (AN) is a mental health disorder characterized by severe caloric restriction, primarily affecting adolescent females (lifetime prevalence up to 4%) and males (0.3%). It has the highest mortality rate among mental disorders, at 5%.Beyond significant weight loss, AN causes severe physical consequences du... | Exclusion Criteria:- Patients with other primary eating disorders (e.g., bulimia nervosa, binge eating disorder) without specific subgroup analysis for anorexia nervosa.- Studies including participants with comorbid conditions that could independently affect the outcomes (e.g., severe cardiovascular or endocrine disord... |
CRD42020203829 | We would like to answer two research questions: 1) Is there evidence for parenting behaviors predicting later children’s effortful control, for children’s effortful control predicting later parenting behaviors, and/or longitudinal and transactional relations between them? 2) If heterogeneity exists among relations betw... | We focus on children's effortful control. which refers to a trait-level top-down self-regulation that involves attentional focusing, attentional shifting, inhibition and activation control of behavior, emotion regulation, and basic level cognitive control when it is used for self-regulation (Nigg, 2017; Rothbart, 2011)... | null |
CRD42025646217 | What are the barriers, feasibility, and challenges of implementing community-based palliative care for patients with cancer in India, as reported in observational and interventional studies? | This systematic review focuses on palliative care, a specialized form of healthcare aimed at improving the quality of life for patients with serious, life-limiting conditions, particularly those with cancer. Palliative care addresses not only the physical aspects of patient care, such as pain relief and symptom managem... | null |
CRD42025636888 | The quality of the literatures are evaluated, whether there are large heterogeneity, whether there are publication biases and reporting biases in the included literatures, and the statistical methods were clarified. | Metabolic syndrome is a complex metabolic disorder characterized by the aggregation of multiple metabolic abnormalities such as obesity, hypertension, hyperglycemia, and dyslipidemia in the same individual. This state greatly increases the risk of developing chronic diseases such as cardiovascular disease and diabetes.... | null |
CRD42023434372 | What is the effectiveness of receiving polygenic risk information for cardiovascular disease in risk factor medication, and what are the associated behavioural and psychological impacts in individuals with or without cardiovascular disease? | Cardiovascular disease, coronary artery disease, polygenic risk score (PRS), genetic risk score, genetic risk This review will consider studies that include participants who are adults (defined as 18 years and over) of either sex, any age or ethic group, with and without evidence of CVD. This review will consider studi... | null |
CRD42022328170 | 1. What is the level of mental health literacy in secondary school teachers?
2. What are the existing interventions for improving secondary school teachers’ mental health literacy (MHL) and is there any evidence of effectiveness? | Secondary school teacher or staff mental health literacy | null |
CRD42023434712 | 1. What is the mental health experience of individuals with post-covid fatigue, and what is the severity of their mental health difficulties? 2. What are the techniques and content used in interventions which are effective in improving mental health outcomes for individuals experiencing post-covid fatigue? | The condition being studied is post-Covid fatigue, which is characterised by fatigue symptoms which persist after 12 or more weeks following Covid-19 infection, and are not explained by another diagnosis (NICE Covid-19 rapid guidelines). | null |
CRD420250650227 | What conditions are pharmacist-led in general practises and its impact? What is the patient's perspective of pharmacist-led services in general practice? | Services being provided by pharmacists in general practice Inclusion: any service provided by registered pharmacists in general practice from 2015 to 2024, international studies included, GP and patient perceptions, medication reviews, educating patients or GPs, independent prescribing, any specific clinics (hypertensi... | null |
CRD42022324338 | 1. How is social cognition associated with violence? | Social Cognition in Violence | null |
CRD42023452418 | What is the relationship between neuroticism and anxiety among individuals during the COVID-19 pandemic? | The systematic review focuses on investigating the relationship between neuroticism and anxiety in the context of the COVID-19 pandemic. Neuroticism is a personality trait characterized by emotional instability, a tendency to experience negative emotions, and heightened sensitivity to stressors. Anxiety, on the other h... | null |
CRD420250629794 | 1) How is spirituality in schizophrenia patients? 2) Is spirituality a coping mechanism for schizophrenia, 3) What is the relationship between spirituality and schizophrenia recovery? | (1) studies comprising schizophrenia patients, (2) related to spiritual experiences and descriptions from the first-person perspective, Schizophrenia patients related to spiritual experiences and descriptions from the first-person perspective, The inclusion criteria included (1) studies comprising schizophrenia patient... | null |
CRD42023384630 | This systematic review aims to summarize and clarify the existing evidence concerning the relationship between burnout and employee silence and voice outcomes (Table 1. PICOs). There are three objectives:1. To examine whether burnout is associated with employee silence outcomes (e.g., frequency of reported silence beha... | Burnout is a psychological syndrome that involves a prolonged response to chronic emotional and interpersonal stressors on the job (Maslach et al., 2006). The three key dimensions of job burnout are exhaustion, feelings of cynicism/depersonalization, and a sense of professional inefficacy/lack of accomplishment (Leiter... | null |
CRD42023415470 | The primary research question is ‘What are the psychological feelings of non-suicidal self-injury adolescents? ’
(1) The research objects are adolescents with non-suicidal self-injury behavior; (2) The research content is the psychological experience and feelings of adolescents after non-suicidal self-injury; (3) The r... | Non-suicidal self-injury (NSSI) refers to direct, repeated and socially unacceptable self-injury to bodily tissues without suicidal intent , including cuts, scratches, impacts, and burns, and is a common, significant and highly public health concern. NSSI has a high prevalence in the adolescent population, with a lifet... | null |
CRD420250631495 | Population (P): Individuals diagnosed with Alzheimer’s disease (AD), Parkinson’s disease (PD), or adults assessed for cognitive domains.Intervention (I): Infection with the parasite Toxoplasma gondii, evaluated using IgG, IgM, or PCR tests.Comparison (C): Control groups without infection.Outcome (O): The impact of Toxo... | Cognitive function ; Toxoplasmosis; Alzheimer's Disease The study focuses on the cognitive and neurological implications of Toxoplasma gondii infection, particularly its association with cognitive decline (including memory, cognitive flexibility, verbal fluency) and its potential role in neurodegenerative diseases such... | null |
CRD420250648494 | 1) What is the relationship between sexual violence victimization and self-compassion? 2) What are the mental health correlates of self-compassion among survivors of sexual violence victimization at various points in the lifespan (adulthood, childhood)? | Sexual Assault; Compassion The relationship between sexual violence and self-compassion clinical and nonclinical samples of sexual assault survivors, no other exclusion criteria based on population None. Articles must include at least one measure of sexual victimization across the lifespan and one measure of self-compa... | null |
CRD420250602383 | How effective are virtual reality interventions for childhood anxiety and anxiety disorders? | Childhood; Anxiety Disorder; Anxiety; Virtual Reality; Cognitive Behavioral Therapy; Adolescence Childhood Anxiety and Anxiety Disorders. Children (under 18 years of age) with anxiety disorders and childhood anxiety Virtual Reality; Cognitive Behavioral Therapy; Behavioral Therapy PICO tags selected: Usual Care; Active... | Adults (18 years and above) Studies on the efficacy of VRET on medical pediatric prrocedures will be excluded. |
CRD42021282629 | How does yoga practice affect the post-training recovery from physiological fatigue in football players in comparison to routine recovery methods? | Physiological Recovery from Fatigue after Training in Football Players | null |
CRD42023411677 | Is there any evidence based and clinically pragmatic method to assess testamentary capacity? | Testamentary Capacity | null |
CRD42022312717 | Is the composition of time spent in movement behaviours (sleep, sedentary behaviour/screen time, physical activity) associated with mental health? | Mental health outcomes in non-clinical adult or child populations in relation to 24-hour movement behaviours. | null |
CRD420251001903 | To explore the effects of traditional Chinese medicine formulas in treating depression by regulating the gut microbiota and the microbiota - gut - brain axis through meta - analysis. | meet the diagnostic criteria for depression;The patient is conscious and cooperative. Traditional Chinese Medicine; Herbal medicine PICO tags selected: Usual Care case - control study | Those with comorbid mental disorders; patients with allergic constitution; those who have taken medications for mental disorders or antibiotics within the past two weeks; and those with severe gastrointestinal diseases animal experimental study |
CRD42025635936 | "What is the efficacy of digital therapeutics in improving mental health outcomes, patient engagement, and adherence in psychiatric nursing interventions across different patient populations?" | This systematic review focuses on the use of digital therapeutics (DTx) in the domain of psychiatric nursing for the management and treatment of mental health disorders. The review will examine conditions such as depression, anxiety, schizophrenia, bipolar disorder, and other psychiatric or mood disorders across variou... | null |
CRD420250656437 | What is the impact of nursing interventions on improving access to mental health services among vulnerable populations (Romani people, migrants, and youth) compared to no intervention or standard interventions, according to evidence from clinical trials and cohort studies? | This systematic review focuses on access to mental health services among vulnerable populations, including Romani people, migrants and youth. The study examines how community nursing interventions impact barriers to mental healthcare, such as cultural, geographic, financial and behavioral factors, with the aim of impro... | null |
CRD42024596858 | How do physical (somatic) and psychological symptoms of postpartum depression differ between individualistic and collectivist cultures, and to what extent do cultural norms influence somatisation in these contexts? | This review focuses on postpartum depression (PPD), a mental health condition that affects women after childbirth, characterised by psychological symptoms (e.g., depression, anxiety) and physical or somatic symptoms (e.g., fatigue, headaches). The review will explore how these symptoms differ across cultural contexts. | null |
CRD42024615711 | What is the association between mentalizing ability and NSSI behaviors? This systematic review aims to systematically review and synthesize relevant studies in this area and present a meta-analysis of this association if appropriate. | Mentalizing ability, Non-suicidal self-injury
Non-suicidal self-injury (NSSI) is a prevalent behavior among adolescents and young adults, particularly those facing emotional challenges. Research indicates that NSSI occurs in approximately 15-20% of adolescents, making it a significant concern in mental health.
Mentaliz... | null |
CRD42024620979 | Our aim is to find out the prevalence of anxiety and depression among frontline medical staff in the early stage of the COVID-19 pandemic and explore the potential influencing factors. | Anxiety, Depression, Mental health of medical staff. | null |
CRD420251035821 | What integrated care service models exist for children and young people (aged 0–18) in primary and community care settings? | Inclusion: Individuals i.e. children in the age range of 0-18 years within a Primary/community care service. Integrated services; Collaborative care; Shared Care; Primary healthcare services; Community Care Inclusion Criteria: 1. A care pathway/service model/ framework is discussed in relation with integrated service f... | Exclusion: Individuals above 18 years of age attending non primary/community care services e.g. disability services or acute medical services or residential care services. Exclusion Criteria: 1. Studies not related to integrated care. 2. Individuals above 18 years of age attending non primary/community care services e.... |
CRD42024575022 | Strictly speaking, PICOS is not applicable to this study.
This article explores the relationship between non-suicidal self-injury (NSSI) and negative life events through meta-analysis. Self-harm is an important issue in the field of adolescent mental health, and negative life events are significant risk factors for sel... | Non-suicidal self-injury (NSSI) involves an individual deliberately and repeatedly inflicting damage upon their own body tissue without the intent to die. In the context of adolescence, this issue commands particular attention from health professionals and educators worldwide. Extensive research has identified two prim... | null |
CRD42022339004 | What are children and young people’s experiences of living with IBD? | Inflammatory Bowel Disease | null |
CRD42022298975 | What is the reliability and validity (construct, predictive and incremental) of the SSPI/SSPI-2 in forensic settings? | Psychometric properties. Pedophilia. Pedohebephilia. Screening Scale for Pedophilic Interests. Forensic. | null |
CRD42024574420 | What is the comparative effectiveness of different outreach models in improving substance use outcomes for individuals experiencing homelessness and struggling with addiction? | This review focuses on substance use disorders among homeless populations. | null |
CRD420250616830 | Is Dialectical Behavioural Therapy effective in reducing emotional dysregulation and psychopathology in youth with internalising disorders? | Internalizing behaviour; Anxiety; Depression; Eating Disorder; Suicide; Suicidal Ideation; Self-harm; Emotional regulation ; Posttraumatic Stress Disorder; Somatic symptom and related disorders; Borderline Personality Disorder; Obsessive-compulsive Disorder Youth (6-18years) with internalising disorders/symptomology in... | Exclusion criteria: • Adult populations above 18 years of age. • Diagnoses or symptoms not related to the mental health conditions described above in inclusion criteria. • Special populations (e.g., intellectual difficulties, autism spectrum disorder, medical conditions). Exclusion criteria: NO other therapeutic modali... |
CRD420251030238 | This systematic review aims to elucidate, through the literature, knowledge about the psychological status of patients in the postoperative period of bariatric surgery, taking into account the possible variations that may occur and the repercussions on mental health. | Studies that investigated the association between psychiatric changes and bariatric surgery will be included in this review. Bariatric surgery; Mental Health Screening The database search will be carried out with the selection of the following filters for article types: observational studies. Studies that investigated ... | Studies that exclusively evaluated weight loss or other non-psychiatric outcomes were excluded. Studies that exclusively assessed weight loss or other non-psychiatric outcomes were excluded. |
CRD42024613675 | What is the comparative efficacy of transcranial direct current stimulation (tDCS) versus aerobic exercise in treating depression in adults? | Depression, also known as major depressive disorder (MDD), is a common and debilitating mental health condition characterized by persistent feelings of sadness, loss of interest in daily activities, and a range of physical and cognitive symptoms.
Depression can vary in severity, from mild to moderate to severe, and oft... | null |
CRD420251020562 | The primary objective of this study is to systematically review the existing literature & perform a meta-Analysis to estimate the prevalence of depression among the medical students in south Asia. Additionally, the study also aims to identify & analyze the numerous pre-existing factors associated with depressio... | The review will encompass studies from diverse ethnic groups and genders across south Asian region covering those pursuing degrees such as Bachelor of Medicine and Surgery, Bachelor of Dental Surgery, as well as undergraduate medical students, intern doctors, pre-clinical and clinical students, and both residency and n... | o Non-medical students. o Studies reporting other than South Asian countries medical students. o Studies on healthcare or university students without any subgroup analysis of medical students. Being medical students. |
CRD420251018358 | Is there an increased prevalence of psychiatric disorders among patients with keratoconus compared to individuals without keratoconus? | Patients diagnosed with keratoconus (any age, any setting). Psychiatric patient care Diagnosis of psychiatric disorders, including but not limited to: depression, anxiety, OCD, schizophrenia, autism, ADHD. PICO tags selected: Healthcare services Patients without keratoconus Observational studies: cross-sectional, case-... | Case reports or studies without a comparison or prevalence estimate. case series |
CRD420250630757 | Research Question: What is the prevalence of psychiatric disorders in children and adolescents worldwide, and how do prevalence rates vary by age, gender and geographic region?Sub-questions:1. What are the main risk factors associated with psychiatric disorders in children and adolescents?2. How do prevalence rates dif... | Childhood; Adolescence; Mental disorder; Disease risk factor; Mental Health Review This systematic review focuses on psychiatric disorders affecting children and adolescents. These include conditions such as anxiety disorders, depression, attention-deficit hyperactivity disorder (ADHD), conduct disorders, autistic spec... | Exclusion Criteria: 1. Studies focusing exclusively on adults or mixed populations without separate data for children/adolescents. 2. Non-empirical studies, editorials, or gray literature (e.g., theses). Exclusion Criteria: 1. Studies that focus exclusively on adults or mixed populations with no separate data for child... |
CRD42024579204 | What are the differences in mental health outcomes between art production and appreciation? | Mental health and wellbeing outcomes (anxiety, depression, stress, wellbeing). | null |
CRD420250654988 | Aim 1: To identify the evidence-based treatments or adaptations of evidence-based treatments that have been utilized to treat Muslims with clinical and subclinical psychiatric disorders.Aim 1a: Determine what types of treatments have been delivered to Muslim populations.Aim 1b: Identify which specific disorders have th... | Evaluate the state of the literature on evidence-based treatments for mental health problems among Muslims. Study must include participants who identify as Muslim, regardless of national and ethnic background. Study must include symptoms or diagnosis of at least one mental health and/or substance use problem. A formal ... | Do not identify as Muslim A mental health and/or substance use symptom or diagnosis was not assessed. |
CRD42023457357 | research question is:
What is the efficacy of art therapy interventions in reducing depressive symptoms among children and adolescents with diagnosed depression?
To address this main question, we will further refine our inquiry through the following specific sub-questions:
Population (P): What are the characteristics o... | In our systematic review titled "A Systematic Review and Meta-Analysis of Art Therapy for Depression in Children and Adolescents," we are focusing on the treatment of depression in the pediatric and adolescent population. Depression is a common mental health disorder characterized by persistent symptoms such as sadness... | null |
CRD420250652619 | What are the lived experiences of British Army Officers Wiveswhat are the demands and responsibilities placed on Army Officers Wives and the effect on their psychological wellbeingPsychological wellbeing Army Officers wives | Psychological distress; Psychological well-being; Mental Distress Psychological wellbeing of British Army Officers Wives Women married to Army Officers and the effect on their psychological wellbeingInclusion criteria: Women married to current officers in the British Army Psychological Analysis; Emotional Support; Stre... | Women married to current serving soldiers who husbands were not Army officers Women married to officers who were serving in the Navy, Marines or Royal Airforce Women married to Army officers, whose husband has now left service |
CRD42024554280 | 1. To estimate the pooled association between stress and various indicators of emotional well-being in medical and allied students.
2. To assess the between-study heterogeneity and its possible sources of variations. | This research investigates the various impacts of stress, including its emotional well-being effects. By synthesizing and quantitatively analyzing the consequences of stress, the study seeks to address inconsistencies in previous research. This research targets the students of medical allied subjects from all backgroun... | null |
CRD42024532820 | Broad research question: What are clinician’s attitudes towards online therapy?
Specific questions include:
• How do clinicians perceive online therapy overall?
• What are the perceived benefits of online therapy?
• What are the perceived disadvantages or barriers to online therapy?
• How do clinicians understand the d... | Mental health clinicians' attitudes towards online therapy. | null |
CRD420251021161 | How do probiotics and prebiotics affect gut microbiota composition in humans? | Healthy adults or adults with depressive disorders, anxiety disorders, sleep disorders, or pain. Probiotics; Prebiotics ecas | Inclusion criteria: Age: Adults (≥18 years). Health status: Healthy individuals or those diagnosed with depressive disorders, anxiety disorders, sleep disorders, or chronic pain. Intervention: Studies evaluating the effects of probiotics and/or prebiotics on gut microbiota and their relationship with mental health. S... |
CRD420251030337 | The primary objective of this review is to investigate the association between online gambling and substance dependence in children and adolescents. Specifically, the review will address the following questions: | Age group: Individuals aged 18 years or younger (children and adolescents) Condition: Participants involved in online gambling activities, with or without a diagnosed substance use disorder. Geographic criteria: Studies conducted globally, including both developed and developing countries. Language: Studies published i... | Age group: Individuals older than 18 years (adults). Condition: Participants who do not engage in online gambling activities or who do not have a diagnosis of substance use disorder. Language: Studies published in languages other than English or Greek. Study type: Studies that do not focus on the relationship between... |
CRD42024502091 | Aim: To systematically review the literature to assess the effectiveness of (digital) resource-oriented interventions (both organisational and individual-level) designed to improve work engagement and well-being.
A) How do (digital) resource-oriented organizational-level and individual-level interventions impact work e... | In our systematic review, we focus on mental health in the workplace, a critical area of research given the profound impact work has on employees' psychological well-being. Specifically, we will examine perceived work engagement as a indicator of well-being. This involves exploring how resource-oriented interventions (... | null |
CRD420251001065 | null | Cognitive Behavioral Therapy; Behavioral Therapy; Group Cognitive Behavioural Therapy; Internet-delivered Cognitive Behavioural Therapy; Mindfulness-based Cognitive Therapy; Sleep And Rest Interventions; Motivational Interviewing Technique; Mindfulness; Bright white light therapy; Psychotherapy; Psychosocial Interventi... | null |
CRD42022340129 | Primary: To compare the complication rates of different fusion techniques for the surgical treatment of lumbar degenerative spondylolisthesis using two classification schemes (general classification that includes intraoperative and post-operative complications, and modified Clavien-Dindo classification), including ALIF... | Primary: What is the most effective fusion surgery for improving disability and pain in adults with degenerative
spondylolisthesis.
Secondary: What is the most effective treatment for improving and mental health in adults with degenerative
spondylolisthesis.Complication reporting follows different formats, during or fo... | null |
CRD420250610648 | This systematic review and meta-analysis aim to evaluate the effects of cannabidiol (CBD) use for the treatment of neuropathic pain or neuropathies during pregnancy on neonatal outcomes. Neuropathic conditions may require pharmacological management, but the safety of CBD use in this context remains unclear, especially ... | Cannabinoids; Pregnancy ; Neonatal Death The condition being studied in this systematic review is the use of cannabidiol (CBD) for managing neuropathy in pregnant women and its potential impact on neonatal outcomes. Neuropathy, a condition resulting from nerve damage, can cause severe pain, sensory disturbances, and fu... | Exclusion criteria include studies where participants used cannabis products containing THC or those unrelated to neuropathy. Studies without neonatal outcomes or focused only on maternal health, as well as non-human studies, will also be excluded. Exclusion Criteria involve studies where CBD was used for conditions un... |
CRD42023380735 | 1. What are the tools that have been validated for alcohol screening for problem drinking in older persons(over 65’s)
2. What is the accuracy for each of these alcohol screening tools for identifying problem drinking in older persons (over 65's) | Screening tools for problem drinking in older adults (over 65's). | null |
CRD42024526211 | (1) What factors are related to the development of burnout in student-athletes?
(2) How does burnout affect student-athletes?
(3) Is student burnout related to athlete burnout?
(4) Can this information be used to develop a transcontextual model of student-athlete burnout? | Burnout (student burnout and athlete burnout) | null |
CRD420250656267 | What is the effect of Transcranial Alternating Current Stimulation (tACS) in reducing hallucinations in patients with psychiatric disorders compared to other Non-invasive Brain Stimulations?
P - Patients with any psychiatric disorder experiencing hallucinations.
I - tACS
C - Other treatment as usual or any other modali... | The psychotic symptom of ‘Hallucinations’ across various psychiatric disorder. | null |
CRD420251029828 | Review question: In patients hospitalized in intensive care units, what is the effectiveness of music in reducing neuropsychiatric symptoms compared to any other type of intervention? | Studies including patients over 18 years of age hospitalized in the ICU who are conscious or able to respond to questions. Music Therapy PICO tags selected: Usual Care; Placebo; Non-Pharmacological Interventions; Pharmacotherapy | Studies including patients over 18 years of age with pre-existing mental health disorders prior to ICU admission, older adults with cognitive impairment, or neurocritical patients experiencing an acute episode. |
CRD42025565969 | The relationship between loneliness and psychosis is highly complex. Though plenty of studies have substantiated a correlation between loneliness and psychosis, a thorough understanding of the interaction between mutually occurring and underlying variables has proven difficult to explicate. Previous systematic reviews ... | Psychosis and the experience of loneliness in people with psychosis | null |
CRD420250614684 | - What are the mental health experiences of transgender/ gender diverse autistic individuals? - What are the risk factors that increase mental health difficulties for transgender/ gender diverse autistic individuals? - What are the protective factors which decrease mental health difficulties for transgender/ gender div... | Mental Health History The review is being completed as a part of the DClinPsy trainee project. The review will look to explore the mental health experiences of transgender individuals who are autistic (self-diagnosed or formally diagnosed). The empirical paper will look at the experiences of transgender/ gender diverse... | - Papers which report only quantitative data. |
CRD420250645699 | In adult patients diagnosed with schizophrenia-spectrum disorders, does the use of statins as adjunctive therapy, compared to conventional treatment, improve clinical symptoms? | Schizophrenia spectrum disorders are a group of mental health conditions characterized by disturbances in thought, perception, emotions and behavior, which includes schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, and brief psychotic disorder. The symptoms are hallucinations, del... | null |
CRD42025642260 | 1) What are the short and long term mental health impacts of dating violence on youth ?
2) How do sociocultural elements such as patriarchal norms family honor and societal expectations, contribute to the prevalence and manifestation of dating violence.
3) What gaps exist in the current literature on dating violence in... | There are a number of definitions of Dating violence given from time to time by different researchers . Perhaps the most influential definition is provided by Sugarman & Hotaling (1989) defining dating violence as all words, gestures, or actions that involve threatening or using painful or harmful physical or psycholog... | null |
CRD420250645717 | What is the effectiveness of telehealth-based psychological support interventions in improving mental health outcomes (such as anxiety, depression, and quality of life) for pediatric oncology patients and their families? | Cancer Pain; Problematic Behavior In Children; Telehealth; Anxiety; Depression Pediatric oncology patients (0-18 years) and their families. Telehealth-based psychological support (e.g., family counseling, psychoeducation). Anxiety, depression, quality of life, caregiver burden, family functioning, patient/family satisf... | Non-pediatric oncology populations In-person interventions or non-psychological interventions |
CRD420251018266 | This review will identify the available community-based psychosocial interventions that support parents after a pregnancy loss or the death of a baby (up to 30 days old). To do so, this review will answer the following research questions: | Parents bereaved by a perinatal loss including miscarriage, termination of pregnancy due to fetal anomaly (TOPFA), stillbirth, and neonatal death (up to 1 month of life). As gestational age varies globally, there will be no restrictions on gestational age used in definitions. This review takes into account a broad defi... | Non-human participant study Abortions not related to foetal anomaly 1. Studies implemented in secondary and tertiary hospitals, specialist medical and research facilities 2. Interventions that are not psychological or social 3. Interventions that are not targetting psychological outcomes (including but not limited to a... |
CRD42019134461 | Do facilitated arts psychotherapies improve the mental health of young people with long-term physical health conditions? | Mental health and well-being in long-term paediatric physical health conditions, including, for example: rheumatological diseases, inflammatory and autoimmune conditions or cancer. Inclusion: children and adolescents (aged 18 years or under), with long-term physical health conditions, in inpatient or outpatient setting... | null |
CRD420250656549 | "In patients with diabetes, how do diabetic foot ulcers affect quality of life as measured by the SF-36 compared to diabetic patients without foot ulcers and healthy patients? | Diabetic Foot Ulcer Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, primarily resulting from neuropathy and poor peripheral circulation. These ulcers significantly increase the risk of infections, leading to prolonged hospital stays and even lower limb amputations. DFUs not only affect phy... | null |
CRD420250610639 | Does Vitamin E supplementation reduce biomarkers of oxidative stress (such as malondialdehyde [MDA], glutathione [GSH], superoxide dismutase [SOD], and catalase [CAT]) in patients with schizophrenia compared to placebo or standard care? | Schizophrenia; Vitamin E; Placebo Adults diagnosed with schizophrenia or other chronic mental illnesses (such as schizoaffective disorder or bipolar disorder), according to any recognized diagnostic criteria. Individuals who have developed antipsychotic-induced tardive dyskinesia (TD), with TD defined as persistent, in... | Individuals without a diagnosis of schizophrenia or another chronic mental illness. Patients who have not developed antipsychotic-induced TD (i.e., those without clinical evidence of TD as defined by standardized criteria such as the Abnormal Involuntary Movement Scale). Studies involving only animal or in vitro model... |
CRD42024550032 | 1. What is the prevalence of mental health disorders among school-aged children living in Regional, Rural and Remote (RRR) Australia?
2. Are there differences in rates of mental health disorders according to geographical location in Australia, particularly between children living in metropolitan Australia compared to t... | Mental health disorders in children and adolescents | null |
CRD420250653288 | What is the effect of probiotic administration on rodent models of Multiple Sclerosis? | Multiple sclerosis (MS) Our review will consider mice or rat models with multiple sclerosis. In this systematic review, we will examine the effect of probiotic administration in rodent models of multiple sclerosis. Different strains, doses, and duration will be considered in this review. Control intervention groups wil... | 1. Animal models other than those for multiple sclerosis.
2. Animal species other than mice or rats.
3. Studies that are exclusively in vitro, ex vivo, in silico, or conducted on humans. Exclusion criteria: All interventions except for probiotics are excluded. Any groups not specified in the inclusion criteria |
CRD42022363592 | The goal of this systematic review and meta-analysis is to synthesize empirical research on the link between minority stress exposure and emotion regulation processes, including strategies and abilities. We hope to address the following questions:
1. What emotion regulation strategies and abilities have been examined b... | This review focuses on minority stress, i.e., forms of stress that relate directly to one’s sexual and/or gender minority status. Minority stress can be conceptualized as distal (e.g., structural inequities) and proximal (e.g., internalized stigma). Emotion regulation processes refer to both strategies and abilities pe... | null |
CRD420250614649 | Question: How and why are Single Case Experimental Designs (SCEDs), utilizing Ecological Momentary Assessment (EMA), used persons with a psychiatric diagnosis and what are the outcomes of these studies? | Persons with a DSM-V psychiatric diagnosis (transdiagnostic) Inclusion: Persons diagnosed with a psychiatric diagnosis as included within the DSM-V. Clinically assessed and/or with a diagnostic instrument/ questionnaire. Ecological Momentary Assessment (EMA) or comparable (including: "Ecological Momentary Assessment", ... | Persons without a psychiatric diagnosis Interventions without incorporation of a clinician who (a) assessed and/or manages, (b) prevents, (c) monitors, or (d) measures study participants and interventions that do not take place in a mental health care setting, will be excluded. |
CRD42023410525 | How has the COVID-19 pandemic impacted the mental wellbeing and related physical health of Indigenous youth throughout Canada and USA based on geographic location, age, protective and risk factors?
The objectives are to (1) explore the different mental wellbeing and related physical health impacts; (2) identify moderat... | Mental health and wellbeing (e.g., depression, anxiety, loneliness, fear, mental illnesses/disorders, phobias, isolation, withdrawal, sadness, mood, emotions, stress, trauma, wellness, behavior problems, PTSD, OCD, suicidality, quality of life) and/or physical health and wellness and/or resiliency/protective factors/ri... | null |
CRD420250627222 | Objectives or Questions of the Review: | Temperamental; Epigenome level; Temperament Testing This systematic review focuses on the emerging field of morphogenetic temperaments, which integrates psychoneuroimmunoendocrinology (PNIE) and epigenetics to propose a novel typology of human temperament. The study explores how psychological, neurological, immunologic... | "The exclusion criteria for the population in this systematic review include studies conducted on animals, participants with severe or chronic medical conditions that could significantly impact psychoneuroimmunoendocrine systems, and non-human populations. Studies that do not directly assess morphogenetic temperaments ... |
CRD42020188306 | Do Migraineurs have disturbed autonomic functioning as measured by blood pressure and heart rate variability when compared to healthy controls?
Do migraineurs have disturbed endocrinological function as measured by cortisol and the sex hormones; estrogen, progesterone and testosterone, compared to healthy controls? | Migraine Disorders, Autonomic and Endocrinological functioning withing migraineurs as compared to healthy controls. | null |
CRD420250656441 | The question guiding the review is: What is the relationship between urban living environment (indicators, combinations, patterns) and mental health? The primary objectives of the systematic review are as follows:1. To identify and synthesis evidence and assess whether significant relationship exist between urban livin... | Mental disorder; Environmental Exposure Inclusion: general population lives in urban areas, which is not limited by age, gender, occupation, or other demographic characteristics, aside from the type of residential area (urban/rural)The definition of "urban areas" in this review: The review adopts a broad definition of ... | Exclusion: general population lives in rural areas; studies based on regional or national samples that did not analyse participants classified as urban residents separately Exclusion: Studies will be excluded if the exposure factors only include physical environment indicators or only social environment indicators, are... |
CRD42020210128 | • What are the risk predictors of PTSI among first responders during COVID-19 pandemic?
• What is the impact COVID-19 pandemic on the mental health (PTSI) of first responders?
• Which interventions are more effective in reducing the prevalence of PTSI in the first responders? | Nowadays, COVID-19 pandemics pose unique challenges to first responders, especially healthcare/ emergency services personnel. Post-traumatic stress injuries (PTSI) is considered common adverse psychological reactions among first responders (Firefighters, Police officers, Forest fire inspectors, Ambulance drivers and Pa... | null |
CRD420250640888 | The overall review question is: What characterizes interventions in the existing literature that seek to provide family engagement in Forensic Mental Healthcare Settings.The qualitative conzeptualization model PICo will be applied to define the elements within the review question:The Population (P) defines as adult fam... | Family intervention Healthcare domaine, Forensic mental healthcare. Adult family members (aged 18 and above) to service users, who are cared for in forensic mental healthcare settings. Interventions seeking to provide family engagement to service useres aged 18 and above, who are cared for in forensic mental healthcare... | null |
CRD42024578464 | Is there evidence on the nutritional outcomes of infants born to mothers with mental illness compared to those born to mothers without mental illness? | The domain being studied -Nutritional status in infants who are born to mothers with mental illness.
Infants born to mothers with mental illness face high risks of nutritional status abnormality, which can have lifelong developmental consequences. Maternal mental health directly affects feeding practices and infant car... | null |
CRD42023483085 | What are the experiences of service users who participate in prison-based democratic therapeutic communities? | Therapeutic Communities (TCs) have evolved and adapted to meet population needs, including the most serious and complex offenders residing in prisons (Rawlings & Haigh, 2017). Prison based Democratic Therapeutic Communities (DTCs) are recognised as part of the UK’s Offender Personality Disorder (OPD) pathway programme,... | null |
CRD420250655267 | How do parents of children with an intellectual disability experience and navigate their child's transition to adulthood across healthcare, education and social domains? | Intellectual Disability Intellectual Disability. Parents experience of child with ID transition to adulthood. Inclusion: Parents or primary caregivers of individuals with an intellectual disability. Individuals with an intellectual disability will be aged 16 to 40 years of age. Will include individuals if past the age ... | Exclusion: - Studies focusing on Intellectual disability with no parental perspective. - Studies where focus is on developmental or neurodevelopmental disorders or mental health conditions. - Studies of young child or adult children past the point of transition. |
CRD42020188823 | The aim of this meta-analysis which includes several randomized controlled trials is to evaluate the effect of Transcranial Direct Current Stimulation (tDCS) on sleep. | Sleep disorder is a major public health problem at home and aboard. It is always strongly associated with other somatic and mental health problems as well as with an increased mortality rate. Transcranial direct current stimulation(tDCS), which is a safe, convenient, and low-cost technology, has been confirmed by sever... | null |
CRD42024506249 | The relationship between values and subjective well-being is an important topic in psychological research. Over the past few decades, psychologists have conducted extensive research on people’s subjective well-being and identified many factors influencing well-being, with values considered an important influence. The r... | The relationship between self-concept and well-being has been widely explored in social psychology, with scholarly attention recently turning to the link between self-enhancing values and subjective well-being. Self-enhancement values represent individuals' motivation to enhance their personal interests, emphasizing pu... | null |
CRD42020218644 | In post-stroke patients, does neurologic music therapy result in improved outcomes of mental health (depression, anxiety, sleep, behaviours) as well as cognitive function, speech or motor movement and is this reflected by physiological measures such as cardiovascular health. comparators = music listening or other non-m... | Stroke and rehabilitation outcomes | null |
CRD420250650450 | 1. What is the effectiveness of SSCM for the treatment of clinical eating disorders? | Psychotherapy; Eating Disorder The use of Specialist Supportive Clinical Management (SSCM) as a psychological therapy for patients diagnosed with an eating disorder. This may be as part of a recovery focussed intervention (such as with the aim of weight restoration or symptom reduction) or a harm minimisation strategy ... | Studies that explore the treatment of eating disorders utilising other methods (such as other therapies, non-psychological approaches or pharmacology) and do not include SSCM as a comparator will be excluded. |
CRD42025646385 | How does physical exercise (including Yoga, High intensity interval training, Aerobic Training?Resistance
Training, Behavioral weight loss ) and Cognitive behavioral therapy intervention treat adults with binge eating disorder? And the comparison of these two therapeutic effects. | Efficacy of physical exercise and cognitive behavioral therapy on depressive symptoms, binge eating frequency, and body composition in adults with binge eating disorder. | null |
CRD42014015452 | To conduct a quantitative systematic evidence synthesis to identify those models of self-care support for children and young people that are associated with reductions in health services utilisation and cost, without compromising health outcomes. | Long term conditions in children and young people. | null |
CRD42024623631 | While the risks of polypharmacy in elderly populations are well-documented globally, there is a lack of research specifically characterizing these risks within the context of China's unique healthcare system and demographic characteristics. Furthermore, the influence of seasonal variations and gender differences on dru... | Polypharmacy, the concurrent use of multiple medications, is increasingly prevalent among elderly patients, particularly those with multiple chronic conditions. This phenomenon is driven by the aging global population and the rising prevalence of chronic diseases such as cardiovascular disease, diabetes, and mental hea... | null |
CRD420250655105 | The review question focuses on the prevalence of consumption of Cannabidiol (CBD) among both clinical and non-clinical samples, as well as which variables are associated with higher prevalence.For this purpose, those peer-reviewed articles reporting CBD prevalence rates were included, regardless country and age group. | Cannabidiol; Prevalence; Abuse The review will be focused on Cannabidiol (CBD) use in different countries and age groups. All population will be included.Exclusion criteria: NA NA | null |
CRD42024520440 | What are school nurses’ experiences of mental health promotion among young people in school and student health care? | The phenomena of interest is the nurses' experiences of mental health promotion among young people. Public health nurses in school and student health care context. Experiences of mental health promotion among young people Not applicable. | null |
CRD42023470954 | To estimate the prevalence of sexual dysfunctional in Medical Staff.
To estimate the related factors of sexual dysfunctional in medical staff | The condition being studied in this systematic review is sexual dysfunction in medical staff. Sexual dysfunction is a broad term that encompasses any problems with sexual desire, arousal, orgasm, or satisfaction. Sexual dysfunction can affect both men and women, and can have various causes, such as physical, psychologi... | null |
CRD420251015932 | The objective of this systematic review and meta-analysis is to evaluate the effects of intermittent exercise interventions at varying intensities on physical and mental health outcomes in sedentary populations. Specifically, the review aims to synthesize evidence from randomized controlled trials and quasi-experimenta... | Inclusion: Adults and adolescents (≥18 years) from any population group who engage in prolonged sedentary behavior, defined as sitting for ≥6 hours per day or classified as sedentary using validated tools (e.g., the International Physical Activity Questionnaire). Participants may be healthy or at risk of sedentary-rela... | null |
CRD42025635861 | What are the most effective strategies to prevent mental health disorders and promote mental well-being in military personnel? | Mental health disorders | null |
CRD42024585707 | In order to clarify the overall prevalence of mental health problems in Chinese raw recruits and further analyze its influencing factors, a meta-analysis will be conducted on relevant studies retrieved from 2000 to 2024. | Chinese raw recruits, mental health | null |
CRD420250641344 | What is the impact of migraine on workplace productivity and the cost of lost productivity in relation to developing and developed countries? | Migraine patients experience migraine symptoms such as headache, nausea, vomiting and aura that occur in attacks. This situation affects their daily living activities, psychological state, and work life. The researchers will work on migraine patients in this review.Inclusion criteria1) studies investigating migraine2) ... | null |
CRD420250620512 | Population - older adults (age over 65) worldwide.Exposure - a range of ambient temperatureComparison - Comparisons between places or time periods at relatively lower or higher temperaturesOutcome - cognitive function (based on any validated measure of cognition)Study Design - Population / Cohort studies, case-control ... | Congitive function in older adults across different domains assessed using formal congitive assessment. Including memory, language and visuospacial and executive function. Older adults, ages >= 65. If the majority or patients within the study are over our target age the studies will also be included. Participant with o... | null |
CRD42024612300 | What is the prevalence of burnout among healthcare workers in India? | Burnout syndrome; Healthcare Professional ; Mental state; Prevalence Burnout syndrome among healthcare workers, characterized by:Emotional exhaustionDepersonalizationReduced personal accomplishment Inclusion:Healthcare workers in IndiaDoctorsNursesAllied health professionalsHealthcare administratorsBoth private and pub... | null |
CRD42024608752 | What published and peer-reviewed evidence exists for the relationship between the expression of dopamine, glutamate, and GABAergic neurotransmitter receptor subtypes in peripheral blood and Major Depressive Disorder (MDD) in humans? | Major Depressive Disorder (MDD) is a common and debilitating mental health condition characterized by persistent low mood, loss of interest or pleasure in daily activities, and a range of cognitive and physical symptoms, including fatigue, impaired concentration, changes in appetite, and sleep disturbances. MDD affects... | null |
CRD420251004987 | To find out which interventions were carried out for intervening sleep, fatigue and depression all at once and to analyze the effects of those interventions quantitatively and qualitatively. | Adults who are 18 or older and who have an impaired mental health status like depression, insomnia.... Not limited. If the interventions are applied to the participants for improving the problems of sleep, fatigue and depression, any intervention can be included. | Adolescents, Youth |
CRD420250651806 | Primary objectives | Psychometric Testing; Quality of Life The domain being studied is the suitability and performance of quality-of-life outcome measures for adult psychiatric inpatient populations. The population of interest are adult inpatients (psychiatric). The review is not restricted by country, outcome measures used with psychiatri... | Studies that do not include an adult inpatient psychiatric population will be excluded. For example, studies on adolescents or older adults in inpatient psychiatric settings, studies that are not set in adult inpatient psychiatric settings, e.g. community mental health, physical rehabilitation, medical wards. Adolescen... |
CRD420250637840 | Primary question: Are VR relaxation and wellbeing interventions effective at reducing anxiety? Secondary question: Within studies that have used a control group, is there an effect of VR at reducing anxiety?Other questions:What groups of people have the methodologically robust studies of VR relaxation for anxiety been ... | Anxiety Anxiety is a universally experienced human emotion, which involves feelings of dread of anticipatory events and worry. While adaptive in some contexts, heightened levels of anxiety in the general population, alongside anxiety disorders in the clinical population, pose significant health and economic challenges,... | Exclusion criteria: studies involving VR exposure therapy; studies that do not use head-mounted displays. |
CRD42022304029 | What is the association between mental health issues, depression and hepatocellular carcinoma in patients diagnosed with liver cancer? | Patients with hepatocellular carcinoma are commonly associated with mental health disorders, including depression. In this review, we will be analysing the effects of depression and other mental health disorders in affecting the patients. | null |
CRD42024541365 | Broad Review Question: What are the key insights from health professionals and patients regarding pharmacist-led MNS services in low- and middle-income countries (LMICs), and how can these insights contribute to the enhancement of mental healthcare in these settings?
Specific research questions:
1. What types of mental... | Phenomenon of Interest:
Pharmacist-led mental health services encompassing routine practices related to mental healthcare, such as counselling, medication management, education, and advocacy, as well as specific interventions initiated by pharmacists to improve mental health outcomes. | null |
CRD42024599897 | The primary objective of this meta-analysis is to systematically review and quantitatively synthesize the existing literature on electrophysiological microstates in individuals with Autism Spectrum Disorder (ASD). we aim to identify Consistent Patterns determine if there are consistent electrophysiological microstate p... | Preliminary results have been obtained in the field of EEG microstates in ASD, and based on our search results in six databases (PubMed, WoS, EMBASE, EBSCO, Cochrane Library, and PsycINFO), 10 studies were initially included. Some potential consistent advances have been identified in these studies, such as differences ... | null |
CRD42023457722 | Regarding the language used in the review protocol, the term ‘autism’ will be used to encompass all diagnostic terms related to this, including but not limited to: Autism Spectrum Disorder, Asperger’s Syndrome and Pervasive Developmental Disorder.
Review questions:
1. How do young people describe the development of the... | Identity development following diagnosis of Autism in young people.
Autism will be defined as any reported clinical or research diagnosis of Autism Spectrum Disorder, or associated historic diagnoses such as Asperger’s syndrome and Pervasive Developmental Disorder.
Identity will be broadly defined using the framework s... | null |
CRD420251012381 | To explore the effects of Baduanjin exercise on the psychological health and quality of life of cancer patients, providing a scientific basis for rehabilitation interventions for cancer patients. | Adult patients with cancer(as diagnosed using histopathological examination) Exercise therapy Baduanjin exercise is characterized as a traditional fitness modality that integrates physical movement, respiratory regulation, and psychological modulation. PICO tags selected: Usual Care all experimental studies including r... | Adolescents (under 18 years of age) opinion to editors, case studies, theses and dissertations, study protocols, grey literature |
CRD420250646791 | What are the dropout and follow-up rates in elective and emergency hand surgery trials, and what factors contribute to patient attrition in these studies? | The review focuses on dropout and follow-up rates in clinical trials involving elective and emergency hand surgery. Hand surgery encompasses a wide range of procedures aimed at restoring function, alleviating pain, and improving outcomes in conditions affecting the hand and wrist. Elective hand surgery includes procedu... | null |
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PROSPERO Inclusion/Exclusion Criteria Dataset
This dataset is a curated and preprocessed collection of clinical research objectives and their corresponding inclusion and exclusion criteria, extracted from the PROSPERO international prospective register of systematic reviews.
Description
The dataset was constructed to support fine-tuning of large language models (LLMs) for tasks involving the automated generation of eligibility criteria based on research objectives. It contains English-language research objectives from systematic review protocols across three domains:
- Mental health
- Diagnostics
- Therapeutics
Dataset Structure
Each row in the dataset corresponds to one study protocol and contains:
Study_ID: The unique identifier from PROSPERO (e.g., CRD420250616527)Objectives: The research objective(s) of the systematic reviewIncluded: The criteria defining which participants/studies are eligible for inclusionExcluded: The criteria used to disqualify participants/studies from inclusion
Use Case
This dataset is ideal for training or fine-tuning LLMs (like T5, Mistral, LLaMA) on:
- Generating inclusion/exclusion criteria from research objectives
- Biomedical text-to-text reasoning tasks
- Automating systematic review assistance and meta-research workflows
Format
- File type: CSV (
utf-8) - Fields:
Study_ID,Objectives,Included,Excluded - Suggested fields for fine-tuning:
input_text: Prompt generated fromObjectivesoutput_text: "Inclusion: ... Exclusion: ..." combined string
License & Attribution
Data is sourced from PROSPERO, a publicly accessible database, and is intended for educational and research purposes only. Please cite the original PROSPERO records when using this dataset in any published work.
🙌 Created By
Sanaa as part of her mission to automate and enhance systematic literature reviews using AI. email: sanaa.abril@gmail.com
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