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Instruction: Using the provided medical research article, generate a summary. a recent systematic analysis showed that in 2011 , 314 ( 296 - 331 ) million children younger than 5 years were mildly , moderately or severely stunted and 258 ( 240 - 274 ) million were mildly , moderately or severely underweight in the d...
Instruction: Using the provided medical research article, generate a summary. it occurs in more than 50% of patients and may reach 90% in certain types of cancers , especially in patients undergoing chemotherapy and/or radiation therapy.1 anemia is defined as an inadequate circulating level of hemoglobin ( hb ) ( hb...
Instruction: Using the provided medical research article, generate a summary. tardive dystonia ( td ) , a rarer side effect after longer exposure to antipsychotics , is characterized by local or general , sustained , involuntary contraction of a muscle or muscle group , with twisting movements , generally slow , whi...
Instruction: Using the provided medical research article, generate a summary. lepidoptera include agricultural pests that , through feeding and other activities , negatively affect stored grains , food and fiber crops [ 2 , 3 ] . since a single lepidoptera adult can produce hundreds of eggs , and their primary food ...
Instruction: Using the provided medical research article, generate a summary. syncope is caused by transient diffuse cerebral hypoperfusion and is characterized by transient loss of consciousness with a rapid onset followed by spontaneous and complete recovery . clinical features of syncope may include myoclonic jer...
Instruction: Using the provided medical research article, generate a summary. world - wide , infertility affects 1015% of couples who are trying to conceive , and about 15% of these cases are caused by male factors , which affect 1 out of 20 men in the general population . most cases of male infertility are idiopath...
Instruction: Using the provided medical research article, generate a summary. midwife - led primary delivery care for low - risk pregnant women during labor has been reported to have various advantages , such as increased odds of high maternal satisfaction and a decrease of unnecessary medical interventions [ 18 ]...
Instruction: Using the provided medical research article, generate a summary. diabetes decreases the overall life expectancy and cause a heavy burden on public health ( 1 ) . moreover , the asia - pacific region is considered to be on the verge of an emerging diabetes epidemic ( 2 ) . the development of type 2 diabe...
Instruction: Using the provided medical research article, generate a summary. lipid apheresis provides a safe and effective means of treating patients with severe hyperlipidemia . it functions by first separating plasma from blood cells with a cell separator and then using either the adsorption of apolipoprotein b b...
Instruction: Using the provided medical research article, generate a summary. agenesis of the inferior vena cava ( ivc ) as a cause of recurrent deep vein thrombosis ( dvt ) is uncommon . a 33-year - old male with no family history of thrombophilia , who had experienced multiple recurrent episodes of dvt over a 15-y...
Instruction: Using the provided medical research article, generate a summary. an exponential rise in alzheimer 's disease ( ad ) prevalence rates is predicted to parallel the aging of baby boomers creating a potentially unsustainable economic burden to the healthcare system . delaying the onset or progression of a...
Instruction: Using the provided medical research article, generate a summary. Response: we compared serum polychlorinated dibenzo - p - dioxins ( pcdds ) and polychlorinated dibenzofurans ( pcdfs ) among residents of two homes to levels among age- and sex - matched comparison subjects . the residents of the tw...
Instruction: Using the provided medical research article, generate a summary. the wnt/-catenin pathway has been implicated in the development and progression of melanoma and a wide range of cancer types , including colorectal cancer , breast cancer , esophageal carcinoma , and liver cancer [ 13 ] . under normal co...
Instruction: Using the provided medical research article, generate a summary. the guanine heterocyclic ring is rich in chemical reactivity toward oxidants and adduct - forming species . in dna , 2-deoxyguanosine ( dg , mass = m ) is the chief site for base oxidation due to its low redox potential leading to ...
Instruction: Using the provided medical research article, generate a summary. a review of the literature and an extensive medline search revealed that this is the first case report of the use of guaifenesin to increase sperm motility . he reported an inability to conceive with his wife after 18 months of unprotected...
Instruction: Using the provided medical research article, generate a summary. agriculture has been one of the primary economic avenues in the philippines contributing to about 20% to the gross domestic product ( gdp ) . crops comprise about 47.56% of the total agricultural sector and have contributed to about 510 ...
Instruction: Using the provided medical research article, generate a summary. evans , using a mouse mutant for the lim homeodomain transcription factor ( islet1 , isl1 ) , demonstrated that an isl1 positive ( isl1 + ) population is localised in the secondary heart field ( shf ) , contributing to the outflow tract , ...
Instruction: Using the provided medical research article, generate a summary. primary diffuse leptomeningeal gliomatosis ( pdlg ) is a rare neoplasm with a short survival time of a few months . we report on a 53-year - old male patient who presented with epileptic seizures , gait disturbance , paraparesis and sensor...
Instruction: Using the provided medical research article, generate a summary. in past years , numerous studies have described the role of microalbuminuria ( mau ) as a predictor of cardiovascular disease ( cvd ) and death among subjects with type 2 diabetes ( t2d).13 mau is one of the earliest clinical signs for dia...
Instruction: Using the provided medical research article, generate a summary. cancer is the second leading cause of mortality and morbidity in both developed and developing countries . in india , cancer prevalence is estimated around 2.5 million , with over 0.8 million new cases and 0.5 million deaths occurring each...
Instruction: Using the provided medical research article, generate a summary. der p 1 was isolated from house dust mite fecal pellets ( allergon ) by a multistep procedure 6 involving immunoaffinity chromatography on immobilized anti der p 1 mab ( clone 4c1 ; indoor biotechnologies ) , removal of contaminating seri...
Instruction: Using the provided medical research article, generate a summary. given the risk of paralysis associated with cervical transforaminal injection , is it time to reconsider transforaminal injections of the lumbar spine ? arguments for discontinuing lumbar injections have been discussed in the anesthesia li...
Instruction: Using the provided medical research article, generate a summary. Response: because of rampant concern that estrogenic chemicals in the environment may be adversely affecting the health of humans and wildlife , reliable methods for detecting and characterizing estrogenic chemicals are needed . it i...
Instruction: Using the provided medical research article, generate a summary. alzheimer 's disease ( ad ) is a neurodegenerative disorder that is clinically characterized by progressive mental decline and histopathologically defined by highly abundant amyloid deposits and neurofibrillary tangles in the brain parench...
Instruction: Using the provided medical research article, generate a summary. musculoskeletal tissues show increased bone fragility , loss of cartilage resilience , reduced ligament elasticity , loss of muscular strength , and fat redistribution decreasing the ability of the tissues to carry out their normal functio...
Instruction: Using the provided medical research article, generate a summary. migraine is the leading neurological cause for seeking medical care , and is associated with significant disability in the sufferer . the greatest impact is on migraineurs with headaches on more days than not , a condition defined as chron...
Instruction: Using the provided medical research article, generate a summary. m1dg ( 3-(2-deoxy--d - erythro - pentofuranosyl)-pyrimido[1,2-]purine-10(3h)-one ) is one of many endogenous exocyclic lesions derived from the reaction of dna with bifunctional electrophiles generated by lipid , protein , or dna perox...
Instruction: Using the provided medical research article, generate a summary. a 60-year - old woman ( height , 162 cm ; weight , 61 kg ) visited pain clinic with tactile allodynia and electric shock - like pain in the left dorsal scapular area around the t3 dermatome , which had been diagnosed as phn about 1 month p...
Instruction: Using the provided medical research article, generate a summary. central retinal vein occlusion ( crvo ) is a common sight - threatening vascular disease with prevalence rates ranging from 0.1%1 to 0.5%2 in the older adult population . crvo is characterized by occlusion of the central retinal vein and c...
Instruction: Using the provided medical research article, generate a summary. small bowel obstruction ( sbo ) is one of the most feared complications after a gastric bypass . it can be chronic or acute and can range from a nuisance to the patient to a life - threatening emergency sbos related to adhesions occur afte...
Instruction: Using the provided medical research article, generate a summary. the following section describes the treatment procedure for patients with deep infection following tka using modified static spacers . the original prosthesis was removed , followed by intensive irrigation and wide debridement of the infec...
Instruction: Using the provided medical research article, generate a summary. mental fatigue is common and can be a disabling long - time condition following a stroke . it has been estimated that about 3070% of stroke survivors complain of fatigue [ 17 ] . even for those with an almost recovered stroke and without n...
Instruction: Using the provided medical research article, generate a summary. cigarette smoke ( cs ) is associated with the development of inflammation - related diseases such as chronic obstructive pulmonary disease and vascular diseases , including atherosclerosis and stroke . several studies have revealed that cs...
Instruction: Using the provided medical research article, generate a summary. 4cl4-coumarate : coa ligasecas9crispr - associated protein 9crisprclustered regularly interspaced short palindromic repeatsctcondensed tanningrnaguide rnammillionpamprotospacer adjacent motifpol iiirna polymerase iiirnairna interferencer...
Instruction: Using the provided medical research article, generate a summary. like co@fe3o4 , which recently underwent extensive study to elucidate both the oxidative stability of the core and the phase of the shell , fept@fe3o4 core shell nanoparticles can be used as building blocks to form nanocomposites ...
Instruction: Using the provided medical research article, generate a summary. ionic calcium ( ca ) controls multiple cellular signaling processes in all eukaryotic cells , including proliferation , gene expression , and neurotransmitter release . ca - binding proteins such as calmodulin play a pivotal role in ca sig...
Instruction: Using the provided medical research article, generate a summary. health is not only related to the absence of the disease , therefore we need to conceptualize and operationalize what health is . increasingly , we have come to understand that information about functional status is needed in order to appr...
Instruction: Using the provided medical research article, generate a summary. the centers for disease control and prevention ( cdc ) and united states preventive services task force ( uspstf ) recommend universal hiv screening for all pregnant women entering prenatal care [ 1 , 2 ] . this screening enables hiv - inf...
Instruction: Using the provided medical research article, generate a summary. childhood obesity is a serious and growing public health problem that has arisen over the past three decades . the increasing occurrence of disorders such as type 2 diabetes during childhood is believed to be a consequence of this obesit...
Instruction: Using the provided medical research article, generate a summary. infertility is one of the crucial and critical events in sex life which engages 1015% of couples all over the world , and as one of the most distressful life experiences , exposes couples to social and psychological problems . couples , wh...
Instruction: Using the provided medical research article, generate a summary. balance impairment is an important fall - risk factor , and increases in range of postural sway in the mediolateral direction in older adults are associated with increased fall - risk and rates . postural sway has been shown in older adult...
Instruction: Using the provided medical research article, generate a summary. since the dawn of history , nature and natural sources , such as plants , animals , microbes , and minerals have remained a veritable source of bioactive compounds with medicinal values . among these sources , plants have been the most exp...
Instruction: Using the provided medical research article, generate a summary. erg protein expression has been recently suggested to be reflective of erg gene rearrangements in prostate cancer ( pca ) documenting remarkable concordance between the two [ 16 ] . the rearrangements between the androgen receptor - regula...
Instruction: Using the provided medical research article, generate a summary. the three main arteries of the leg , the anterior tibial artery ( ata ) , posterior tibial artery and peroneal artery , form a dense vascular network around the distal leg , ankle , and foot , which ramifies perforators as the basis of all...
Instruction: Using the provided medical research article, generate a summary. ankle dorsiflexion passive range of motion ( df prom ) measurements are performed in the field of physical therapy to estimate ankle motion during functional activities1 and to prevent lower extremity injuries2 . although in the clinical...
Instruction: Using the provided medical research article, generate a summary. dox is one of the key chemotherapeutic drugs for cancer treatment , but its use is limited by chronic and acute toxic side effects . dox is an antibiotic anthracycline that was isolated from a pigment of streptomyces peucetius in the early...
Instruction: Using the provided medical research article, generate a summary. suicide is a leading cause of death among adolescents and has become a significant public health issue globally ( 1 ) . statistics korea report 2014 showed that suicide is the cause of 28.4% of adolescent deaths in 2013 , and it was the nu...
Instruction: Using the provided medical research article, generate a summary. in the past 15 years , green fluorescent protein ( gfp ) has changed from a nearly unknown protein to a commonly used molecular imaging tool in biology , chemistry , genetics , and medicine . in 2006 , more than 10 000 papers gfps and gfp...
Instruction: Using the provided medical research article, generate a summary. fnas represent an advantageous , effective means to obtain diagnostic cellular material as they can often sample a wide area of the target lesion , acquire tumor cells with lower contamination by background stromal connective tissue elemen...
Instruction: Using the provided medical research article, generate a summary. these tumors are classified as typical net ( tnet ) , goblet cell carcinoid ( gcc ) , and atypical gcc histologies . ex - goblet or composite - goblet are further classified into signet ring cell carcinoid ( srcc ) and poorly differentiate...
Instruction: Using the provided medical research article, generate a summary. Response: we have prepared two new diastereoisomeric 2-aza-5-phosphabicyclo[2.2.1]heptanes from naturally occurring trans-4-hydroxy - l - proline in six chemical operations . these syntheses are concise and highly efficient , w...
Instruction: Using the provided medical research article, generate a summary. igg4-rd is a newly recognized fibroinflammatory condition of unknown etiology characterized by tumefactive lesions , dense lymphoplasmacytic infiltration rich in igg4-positive plasma cells , storiform fibrosis and an elevated serum igg4 le...
Instruction: Using the provided medical research article, generate a summary. treatment duration lasts for months , and is often fraught with potentially dangerous side effects . some of these side effects , such as influenza - like illness , myalgias , depression , and cytopenias can be intolerable resulting in pre...
Instruction: Using the provided medical research article, generate a summary. nathan , as an oncology fellow , knew well that white blood cells fought infections . this was an experiment repeated in front of us all the time , he says : chemotherapy lowered his patients ' white blood cells and increased their risk ...
Instruction: Using the provided medical research article, generate a summary. was initiated by our team about a decade ago , and this has been continued at the medical research center , kasturba health society , mumbai . the comparative effects of three plant products on perimenopausal symptoms , quality of life ( q...
Instruction: Using the provided medical research article, generate a summary. according to the korean national statistical office , the main cause of death in korea was cancer in 2012 . the total number of deaths due to cancer in 2012 was 267,221 , which was increased by 9,825 ( 3.8% ) compared to 2011.1 this was th...
Instruction: Using the provided medical research article, generate a summary. a glomangioma is a benign vascular tumor derived from the glomus body , a specialized neuromyoarterial structure involved in thermal regulation . it is a subtype of the more generalized category of glomus tumors and should not be confuse...
Instruction: Using the provided medical research article, generate a summary. gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole ( complete or partial ) , invasive mole , choriocarcinoma , placental site trophoblastic tumor and...
Instruction: Using the provided medical research article, generate a summary. an expanded research design and methods section and supplementary figures can be found in an online data supplement available at http://diabetes.diabetesjournals.org/cgi/content/full/db09-1293/dc1 . details on glucose and insulin tolerance...
Instruction: Using the provided medical research article, generate a summary. antibodies against amp kinase ( ampk ) , phosporylated ampk ( pampk ) , acetyl coa carboxylase ( acc ) , phosporylated acc , akt , phosporylated akt , and tubulin were from cell signaling ; anti - oxphos was from mitosciences ; anti cd36-...
Instruction: Using the provided medical research article, generate a summary. sarcopenia is present in approximately 513% of persons over the age of 60 years and defined as the loss of skeletal muscle mass and strength with progressive decline in mobility and function . the pathogenesis of sarcopenia is associated w...
Instruction: Using the provided medical research article, generate a summary. temporary henna tattoos or pseudotattoo have become increasingly widespread among children and adolescent , as a safe and economic alternative to permanent tattoos . it is well - known that allergic skin reactions to natural henna are rare...
Instruction: Using the provided medical research article, generate a summary. the romaleidae family accounts for more than 200 species of grasshoppers comprising three subfamilies : romaleinae , aucacrinae and trybliophorinae . it is the second most diverse family of the superfamily acridoidea occurring from semiari...
Instruction: Using the provided medical research article, generate a summary. the relation between chronic subclinical low - grade inflammation and insulin resistance ( ir ) has long been known [ 1 , 2 ] . ir is the major contributor and mediating factor in the development of type 2 dm ( t2 dm ) along with concomita...
Instruction: Using the provided medical research article, generate a summary. . they can be caused by mutations in nuclear genes either relating to mitochondrial components or mitochondrial dna ( mtdna ) . the prevalence of mitochondrial diseases due to mutations in mtdna and related nuclear genes is estimated to be...
Instruction: Using the provided medical research article, generate a summary. prolonged exposure to microgravity has significant effects on physiological conditions . many studies have investigated the effects of microgravity on the neuromuscular system . most of these studies have focused on skeletal muscle changes...
Instruction: Using the provided medical research article, generate a summary. a 55 year - old man visited our emergency department because of increasing frequency of chest pain . he had undergone off - pump coronary artery bypass grafting ( cabg ) 10 years ago because of unstable angina associated with three vessel ...
Instruction: Using the provided medical research article, generate a summary. to report a case of inadvertent anterior chamber and cornea stromal injection with high dose antibiotics and steroids during cataract operation . during cataract operation on a 78 year - old female patient , high dose gentamicin ( 20 mg/0....
Instruction: Using the provided medical research article, generate a summary. autosomal - dominant polycystic kidney disease ( adpkd ) is characterized by cyst formation and occurs primarily in the kidneys . due to the replacement of the normal renal parenchyma , adpkd results in end - stage renal failure in 45% of ...
Instruction: Using the provided medical research article, generate a summary. optimal treatment of cancers in children often requires combined - modality therapy , including : chemotherapy , surgery , and/or radiotherapy . chemotherapy is not always sufficient to achieve the cure of solid tumors in children ; either...
Instruction: Using the provided medical research article, generate a summary. annually , more than 2.5 million muslims from about 140 countries go on the hajj pilgrimage , which is the largest mass gathering in the world . the presence of such a vast number of people in the holy places , especially in the cities of ...
Instruction: Using the provided medical research article, generate a summary. care coordination is an important aspect of nursing care especially for elderly patients admitted to an acute care setting . in singapore care coordination and transitional care nursing is a new concept of care nevertheless important but u...
Instruction: Using the provided medical research article, generate a summary. the irrevocable aim of endodontics is a three - dimensional unblemished seal of the root canal system which is achieved by perfect designing of the canal diameter and canal form . the biomechanical preparation is one of the major steps for...
Instruction: Using the provided medical research article, generate a summary. batch processes are used in production of many low - volume but high - value - added products ( such as speciality chemicals , health care , food , agrochemicals, etc . ) because of operation flexibility in today 's market - driven enviro...
Instruction: Using the provided medical research article, generate a summary. since the introduction of extra - oral implants in reconstruction of craniofacial defects , achieving proper prosthesis retention has become more promising . these problems include ulceration of hard and/or soft tissues used for retention ...
Instruction: Using the provided medical research article, generate a summary. hepatocellular carcinoma ( hcc ) is one of the most common cancers worldwide especially in china [ 13 ] . the high hcc rates in china largely reflect the elevated prevalence of chronic hepatitis b virus ( hbv ) infection . in developed cou...
Instruction: Using the provided medical research article, generate a summary. professional mononuclear phagocytes , such as polymorphonuclear neutrophils ( pmn ) , monocytes , and macrophages , are considered as the first line of defence of the early host innate immune response [ 1 , 2 ] . their main function has be...
Instruction: Using the provided medical research article, generate a summary. the national tb prevalence survey in eritrea was conducted from february through october 2005 ( 6 ) . in 40 selected villages , a census ( which included information about sex and age ) was taken of 875 persons in each village . all person...
Instruction: Using the provided medical research article, generate a summary. spermatogenesis is a complex process of development that occurs in most mammals throughout adulthood period . this process happens in seminiferous tubules , lined with epithelial tissue that contains sertoli cells . sertoli cells are surro...
Instruction: Using the provided medical research article, generate a summary. most malignancies of the upper aerodigestive tract ( figure 1 ) , comprising the naso- , oro- , hypo- , and laryngopharynx , are squamous cell carcinomas . head and neck squamous cell carcinomas ( hnsccs ) are the primary tumor type in hea...
Instruction: Using the provided medical research article, generate a summary. alcoholic liver disease ( ald ) represents a spectrum of clinical illness and morphological changes that range from fatty liver , hepatic inflammation , and necrosis ( alcoholic hepatitis ) to progressive fibrosis ( alcoholic cirrhosis ) ....
Instruction: Using the provided medical research article, generate a summary. this study provides class iii evidence that more patients are seizure - free and have stopped aed treatment in the long term after resective epilepsy surgery than nonoperated epilepsy patients . in sweden , all epilepsy surgery procedures ...
Instruction: Using the provided medical research article, generate a summary. the prevalence of obesity among adolescents in the united states has increased dramatically in the past 30 years , with particularly high rates among hispanic , african american , and native american youth [ 14 ] . currently 33.6% of all a...
Instruction: Using the provided medical research article, generate a summary. student perception of their dental school experience is an essential measure of the success of dental education . undergraduates ' feedback and suggestions are very important for improving the curriculum and learning process . this informa...
Instruction: Using the provided medical research article, generate a summary. a 36-year - old woman complained of an insidious onset of generalized myoclonus that first became apparent at age 27 years . she had no perinatal problems and her development was normal in childhood and juvenile periods . adult - onset myo...
Instruction: Using the provided medical research article, generate a summary. with the worldwide spread of mycobacterium tuberculosis ( mtb ) strains resistant to both isoniazid and rifampicin ( rif ) , multidrug - resistant ( mdr ) tuberculosis ( tb ) has become a major public health problem posing formidable chall...
Instruction: Using the provided medical research article, generate a summary. the hallmark of autoimmune diseases is the pathologic activity of the immune system of an organism directed against its own cells and tissues . the disease is a direct consequence of tissue and/or organ damage as mediated by autoreactive c...
Instruction: Using the provided medical research article, generate a summary. mdct benefits from having a high spatial resolution and fast acquisition time , making it an ideal tool to stage and restage tumours . the routine use of intravenous ( and oral contrast ) media , unless contraindicated , also helps to deli...
Instruction: Using the provided medical research article, generate a summary. the long - term use of immunosuppressive agents for prevention of allograft rejection increases the risk of malignancy approximately 100 times as high as that in the general population . the prevalence rate of post - transplant malignancie...
Instruction: Using the provided medical research article, generate a summary. breast cancer is the most common cancer among american women , except for skin cancers . the chance of developing invasive breast cancer at some time in a woman 's life is a little less than 12% . it is the second leading cause of cancer d...
Instruction: Using the provided medical research article, generate a summary. forensic odontology has established itself as an important and often indispensible science in medicolegal matters and identification of the dead . the forensic importance of dental tissue has been well recognized because tooth is the harde...
Instruction: Using the provided medical research article, generate a summary. cystic echinococcosis ( ce ) is a severe zoonosis caused by the cyclophyllidean cestode echinococcus granulosus . the disease has a worldwide distribution , with endemic regions in many countries of the mediterranean basin , north and east...
Instruction: Using the provided medical research article, generate a summary. septic internal jugular vein - sigmoid sinus thrombosis is a rare condition that complicates local and regional infectious inflammatory processes occurring in the head and neck . these include deep neck infections , lemierre syndrome , and...
Instruction: Using the provided medical research article, generate a summary. they are also used to treat multiple myeloma , bone metastases , and calcium disorders 2 . these patients reportedly often develop bisphosphonaterelated osteonecrosis of the jaw ( bronj ) that is caused by subsequent dental surgery 3 , 4 ....
Instruction: Using the provided medical research article, generate a summary. supported by nci 2p50 ca09825806 , nci u01 ca168394 , stand up to cancer / aacr dream team translational cancer research grant su2c - aacr - dt0209 , tcga gdac grant ( nih / nci u24 ca143883 ) to gbm ; mdacc uterine spore career developmen...
Instruction: Using the provided medical research article, generate a summary. to review the current knowledge about nonpharmacologic approaches in the prevention and early treatment of type 2 diabetes . this study reviewed the research reports dealing with nonpharmacologic interventions aimed at preventing type 2 di...
Instruction: Using the provided medical research article, generate a summary. the function of sensory receptors ( nrec ) in the movement control , muscle coordination and perception of the space position of temporo - mandibular joint ( tmj ) is fundamental although the presence of nrec in the tmj is still debated : ...
Instruction: Using the provided medical research article, generate a summary. areview on the history of mental disorders shows their wide prevalence among human beings always . a glance on statistics reveals that mental disorders and abnormalities are affecting the humans at an increasing pace . the world health org...
Instruction: Using the provided medical research article, generate a summary. polycystic ovary syndrome ( pcos ) which was first reported in 1935 is known as one of the most common endocrine hormones disorders in the women of the reproductive age afflicting as many as % 10 of them . the name of this syndrome has bee...
Instruction: Using the provided medical research article, generate a summary. milrinone , a phosphodiesterase iii inhibitor currently used to treat pediatric patients with cardiac diseases , increases the level of cyclic adenosine monophosphate in the myocardium and vascular smooth muscle . high levels of cyclic ade...