data stringlengths 116 8.75k | criteria stringlengths 19 16.5k | __index_level_0__ int64 0 38.5k |
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Study Objectives
The purpose of this pragmatic cluster randomized control trial is to test the effectiveness of cervical cancer screening follow-up completion using two implementation approaches for self-collected HPV testing in a rural, low-resource setting: 1) community health workers recruiting women door-to-door an... | Inclusion Criteria:
* Women with no previous history of hysterectomy
* aged 25-49 years old
* no previous history of treatment for cervical cancer
* provided written informed consent.
Exclusion Criteria:
* Women who are under 25 or over 49 years of age,
* who have previously had a hysterectomy or been treated for ce... | 9,358 |
Study Objectives
l'ANI (Analgesia Nociception Index
The main objective of the research is to estimate the Analgesia Nociception Index (ANI) as a parameter giving the possibility of measuring the pain in painful metastatic cancer. The parameter ANI is compared with visual analogical scale (VAS) score.
Conditions: Pain... | Inclusion Criteria:
* more than 18 years, -no legal protection, -
* life expectancy is considered over 3-months
* not receiving of béta-blocking,
* Having a rhythm sinusal without extrasystole
* benefiting from a coverage by a social security system
Exclusion Criteria:
* Pace-Maker
* Diabetes mellitus | 16,431 |
Study Objectives
The goal of this clinical research study is to learn if lirilumab in combination with rituximab can help to control either CLL or Small lymphocytic lymphoma (SLL). The safety of the drug combination will also be studied.
Conditions: Leukemia, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia
Interve... | Inclusion Criteria:
* Patients will have a diagnosis of CLL or SLL who meet one or more criteria for active disease as defined by the International Working Group for CLL (IWCLL) and are: a. Cohort 1: refractory to and/or relapsed after at least one prior therapy OR b. Cohort 2: untreated patients with high-risk molecul... | 31,500 |
Study Objectives
* To investigate the effect of catecholamine excess on brown fat.
* To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism
Conditions: Pheochromocytoma, Adrenal Incidentaloma
Intervention / Treatment:
PROCEDURE: Removal of adrenal tumor
| Inclusion Criteria:
* 10 patients with pheochromocytoma
* 5 patients with incidentaloma without hormone production
* Age > 18 years
Exclusion Criteria:
* None | 10,356 |
Study Objectives
This trial intends to test the efficacy and safety of RAD001 in patients with advanced sarcoma who failed to conventional chemotherapy.
Conditions: Soft Tissue Sarcomas, Bone Sarcomas
Intervention / Treatment:
DRUG: RAD001
| Inclusion Criteria:
* Patients with histologically confirmed metastatic, unresectable bone or soft tissue sarcomas who had past treatment with anthracycline and/or ifosfamide to which the disease was primarily refractory or progressed after initial response.
* Any of above drugs is allowed to be used as adjuvant treat... | 38,285 |
Study Objectives
This study designed to determine the Maximum Tolerated Dose (MTD) for patients with advanced Neuroendocrine Tumors (NETs) and to characterize the safety, tolerability, Pharmacokinetics and preliminary efficacy of pasireotide LAR administered i.m. once every 28 days.
Conditions: Neuroendocrine Tumors
... | Inclusion Criteria:
* ≥18 yrs old, histologically confirmed advanced well or moderately differentiated neuroendocrine tumor/carcinoma
* unresectable metastatic NET tumor with measurable disease
* life expectancy ≥ 12 weeks
Exclusion Criteria:
* Patients with CNS metastases who are neurologically unstable or requirin... | 22,155 |
Study Objectives
This phase II trial studies the side effects of palbociclib when given together with fulvestrant or tamoxifen citrate in treating patients with hormone receptor positive breast cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced) or has spread to other places ... | Inclusion Criteria:
* Histologically or cytologically proven diagnosis of breast cancer with evidence of metastatic or locally advanced disease, not amenable to resection or radiation therapy with curative intent.
* Patients 18 years of age or older, Female patients should be either:
* Postmenopausal, as defined by at... | 25,642 |
Study Objectives
This is a pilot, simulated breast cancer screening study. The goal of the study is to explore these scanning modalities:
1) Combined digital breast tomosynthesis(DBT)/dual-sides 3 dimensional-automated ultrasound(AUS)
2. Explore the utility of photoacoustic imaging as an adjunct to digital breast tom... | Inclusion Criteria:
* Women with possible masses
* All women should have had mammograms at University of Michigan Health System within 1 year before this research study.
Exclusion Criteria:
* Women who are physically unable to tolerate the length of the scan.
* Women who are less than 30 years of age or older than 8... | 37,629 |
Study Objectives
The purpose of this study is to determine safety and feasibility of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin and cisplatin in patients with locally advanced gastric cancer undergoing standard surgical resection. Patients will be treated with HIPEC using a single dose of... | Inclusion Criteria:
* Patients aged 18-75 with biopsy-proven gastric adenocarcinoma* Tumor clinically staged T3 or T4 and/or nodes staged clinically positive* ECOG performance status < 2
Exclusion Criteria:
* Distant metastases* Peritoneal carcinomatosis* Synchronous malignancy* Tumors at the gastroesophageal junction... | 16,787 |
Study Objectives
HPV is known to be the causal agent in the majority of cervical cancers. However, the role of the cervical bacterial microbiome in cervical cancer is not clear
Conditions: Cervix Cancer
Intervention / Treatment:
DIAGNOSTIC_TEST: Cervical biopsy
| Inclusion Criteria:
* Women in fertile age
Exclusion Criteria:
* severe comorbidities | 12,833 |
Study Objectives
This study was aimed to evaluate efficacy and tolerability of thalidomide in improving prevention of chemotherapy-induced delayed nausea and vomiting in chemotherapy-naive patients after highly emetogenic chemotherapy.
Conditions: Neoplasms
Intervention / Treatment:
DRUG: Thalidomide, DRUG: Placebo f... | Inclusion Criteria:
* 18y ≤Age≤70y
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
* Histologically confirmed solid neoplasm
* No prior chemotherapy
* Laboratory test must meet the following criteria: hemoglobin (HGB) ≥90g/L, neutrophil count ≥1.5×109/L, platelet count ≥85×109/L, creatinine clearanc... | 31,000 |
Study Objectives
This study is to investigate safety and feasibility of a combination therapy of a tumor infiltrating lymphocytes (TIL) transfer with anti-programmed cell death protein (PD)-1 therapy in patients with metastatic melanoma that failed immunotherapy.Tumor-infiltrating lymphocytes will be expanded from rese... | Inclusion Criteria:
* Histologically confirmed unresectable or metastatic melanoma
* At least 1 PD-1 targeted immunotherapy and BRAF inhibition in case of BRAF mutated melanoma
* Resectable tumor mass and measurable disease by CT or MRI per RECIST 1.1 criteria (in addition to the resected lesion)
* World Health Organi... | 5,787 |
Study Objectives
The objective of the study is to demonstrate the safety, tolerability, and activity of Rituximab-Bendamustine-Cytarabine(R-BAC) regimen in patients with mantle cell lymphoma (MCL) aged 65 years or more, as well as in younger patients who are not eligible for intensive regimens including/not including a... | Inclusion Criteria:
* Previously untreated patients with MCL aged 65 years or more, or <65 years if not eligible for intensive treatments including/not including autologous transplantation.
* MCL patients of any age who relapse/progress or are resistant after one line of chemotherapy.
* CD20+ .
* Karnofsky score of at... | 27,284 |
Study Objectives
The purpose of this proposal is to develop and test the efficacy in a randomized, controlled clinical trial of an Oncology Nurse Care Management (ONCM) program to support cancer patients early in their course. The ONCM program will be compared with an Enhanced Usual Care (EUC) program that will provide... | Inclusion Criteria:
* On the panel of an eligible and consenting primary care physician;* Diagnosed with a new occurrence of breast (females only) , colorectal, or lung cancer within the past three weeks;* Age 18 or older; and* Able to complete the baseline questionnaire.
Exclusion Criteria:
* They plan to disenroll f... | 24,060 |
Study Objectives
The purpose of this study is to evaluate the tolerability of the study drug LY3039478 in Japanese participants with advanced solid tumors.
Conditions: Advanced Solid Tumor
Intervention / Treatment:
DRUG: LY3039478
| Inclusion Criteria:
* Histological or cytological evidence of a diagnosis of solid tumor that is advanced and/or metastatic.
* In the judgment of the investigator, participants must be appropriate candidates for experimental therapy after available standard therapies have failed or for whom standard therapy is not app... | 24,715 |
Study Objectives
To test the efficacy of two Traditional Chinese Medicine in preventing osteoporosis in patients receiving adjuvant endocrine therapy.
Conditions: Breast Cancer, Osteoporosis
Intervention / Treatment:
DRUG: Letrozole, DRUG: Zhongyaofufang, DRUG: Xianlinggubao
| Inclusion Criteria:
* Histologically confirmed invasive breast cancer;
* Post-surgery, primary lesion been removed;
* Post-Menopausal patients or pre-menopausal patients who will receive ovarian function suppression;
* Histologically confirmed ER and/or PR positive ;
* Receiving adjuvant AIs therapy in the following o... | 30,624 |
Study Objectives
This phase 2 waitlist-controlled, randomized trial is designed to compare the difference in proliferative index (Ki67) between carbohydrate restricted diet and usual care over a 6 month period in men with prostate cancer who have been placed on Active Surveillance. Eligible patients include men over 18... | Inclusion Criteria:
* Pathologically confirmed prostate adenocarcinoma
* Most recent biopsy positive for prostate cancer
* Currently on or starting active surveillance
* Ability to read, write, and understand English
* BMI >24 kg/m2
* Written informed consent obtained from subject and ability for subject to comply wit... | 1,060 |
Study Objectives
The purpose of the study is to compare the treatment of esomeprazole 40 mg once daily and lansoprazole 30 mg once daily in controlling intragastric pH in Barrett's Esophagus patients
Conditions: Barrett's Esophagus
Intervention / Treatment:
DRUG: Esomeprazole, DRUG: Lansoprazole
| Inclusion Criteria:
* Documented history (within 2 yrs of histologically proven BE;
* Aged 18-70 (inclusive);
* Willing and able to comply with all study procedures
Exclusion Criteria:
* Signs of clinically significant GI bleeding within 3 days prior to randomization;
* History of gastric or esophageal surgery;
* Cl... | 30,510 |
Study Objectives
The primary objective of this study is the estimation of the human papillomavirus (HPV) 6, 11, 16, 18, 31, 33, 45, 52 and 58 seroconversion at 1 month post last dose (Month 7) following 3 doses and 2 doses of the 9vHPV vaccine. No hypothesis will be tested since this study is an estimation-only study.
... | Inclusion Criteria:
* Is Japanese male or female.
* Is aged at the time of providing the documented informed consent (inclusive): (3-dose boy arm) male from 9 years to 15 years old, (2-dose boy arm) male from 9 years to 14 years old, or (2-dose girl arm) female from 9 years to 14 years old.
* Has a legally acceptable ... | 27,387 |
Study Objectives
While total hysterectomy without lymph node staging is standard for low- and intermediate-risk endometrial cancer, certain histopathologic factors can necessitate additional interventions. Our study assesses the influence of sentinel lymph node (SLN) biopsy on postoperative decision-making.
Conditions... | Inclusion Criteria:
* Age ≥18 years
* Histologically verified low-grade endometrioid adenocarcinoma of the endometrium (G1-G2)
* FIGO stage IA
* FIGO stage IB and II when LND is contraindicated
* No contraindications for surgery
* Signed informed consent
Exclusion Criteria:
* * Age <18 years
* Presence of tumor spre... | 6,956 |
Study Objectives
This study compared two doses of pembrolizumab (MK-3475) versus docetaxel in participants with non-small cell lung cancer (NSCLC) who had experienced disease progression after platinum-containing systemic therapy. Participants were assigned randomly to receive either pembrolizumab 2 mg/kg once every th... | Inclusion Criteria:
* Life expectancy of at least 3 months
* Histologically- or cytologically-confirmed diagnosis of NSCLC that is anti-programmed cell death ligand 1 (PD-L1) positive per central laboratory review
* At least one bi-dimensional measurable lesion
* Radiographic progression after treatment with at least ... | 15,041 |
Study Objectives
The study, investigates the current physical activity promotion practices among physicians and nurses, as well as social norms toward physical activity during treatment among cancer patients and among physicians and nurses who treat or counsel cancer patients.
Conditions: Colorectal Cancer, Breast Can... | Inclusion Criteria:
* HCP are eligible if they meet the following inclusion criteria: Working as an oncological nurse, general practitioner or physician specialized in oncology, radiology, surgery, gynecology, urology, gastroenterology or rehabilitation Signed informed consent
* Patients are eligible if they meet the ... | 21,541 |
Study Objectives
A Phase I, Open-Label, Two Parts Study to Assess the Safety, Tolerability,Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Chinese Patients with Advanced Non-Small Cell Lung Cancer who have Progressed Following Prior Therapy with an Epidermal Growth Factor Receptor Tyrosine Kinase In... | Inclusion Criteria:
* Provision informed consent* Aged at least 18 years* Histological or cytological confirmation diagnosis of NSCLC* Locally advanced or metastatic NSCLC* Radiological documentation of disease progression while on a previous continuous treatment with an approved EGFR TKI. In addition other lines of th... | 11,204 |
Study Objectives
Background: Psychological burden in cancer patients may worsen quality of life and even medical outcomes such as mortality. Nevertheless, many distressed patients are not recognized by the treating clinicians and left untreated even though effective psychosocial interventions exist. Existing screenings... | Inclusion Criteria:
* minimum age of 18 years
* diagnosed with any malignancy according to ICD-10 (first diagnosis or relapse)
Exclusion Criteria:
* Patients with any impairments interfering with the ability to give informed consent | 22,510 |
Study Objectives
Radical cystectomy with urinary diversion is associated with substantial perioperative morbidity, including deep venous thrombosis, prolonged ileus, and postoperative functional decline. Post-operative morbidity after cystectomy prolongs the length of stay, increases the risk of readmission, and adds s... | Inclusion Criteria:
* Planning to undergo radical cystectomy (either with ileal conduit, Indiana pouch, neobladder (e.g., Studer or Hautmann pouch) at the University of Pennsylvania
* Patient has been diagnosed with bladder cancer
* Patient is at least 21 years of age
* Patient is ambulatory with baseline ECOG perform... | 6,662 |
Study Objectives
This is a pilot study to evaluate the feasibility of, adherence to, and early efficacy of Band Together, a strength-training and walking program (intervention arm) vs. education on the benefits of exercise (control arm) in patients with aggressive gastrointestinal (GI) malignancies (gastric, gastroesop... | Inclusion Criteria:
* Age 18 years or older* New diagnosis of potentially resectable or borderline resectable pancreatic adenocarcinoma, gastric adenocarcinoma, or adenocarcinoma of the gastroesophageal junction.* Patients must be evaluated at the Penn State Hershey Medical Center prior to receiving neoadjuvant chemoth... | 7,893 |
Study Objectives
The Evaluating Cancer Survivorship Care Models project is an innovative 3-year study that is collecting data to help understand how to best deliver follow-up care to cancer survivors. Cancer is a complex disease requiring complex treatments that can cause lasting impacts after treatment ends. Some pati... | Inclusion criteria for the CER component:
Survivorship program administrators oversee survivorship programs which:
* See at least 60 new survivors of non-metastatic breast, prostate or colorectal cancer or survivors of any type of cancer yearly
* Represent one of the clinical survivorship care models identified in ou... | 10,050 |
Study Objectives
This is a Phase I, multi-centre, non-randomized, uncontrolled, open-label, dose escalating study of BI 836880 administered intravenously once a week. The eligible patient population will be patients with advanced solid tumors.
The primary objective of this trial is to determine the maximum tolerated d... | Inclusion criteria:
1 Age >=18 years 2. Histologically confirmed malignancy which is locally advanced or metastatic solid tumor, and either refractory after standard therapy for the disease or for which standard therapy is not reliably effective e.g. patients do not tolerate or have contraindications to otherwise avai... | 33,817 |
Study Objectives
CLGX818X2101 is a first-time in-human, phase I study to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of daily administered LGX818 (daily, twice daily and/or every-other-day), a RAF kinase inhibitor. Patients with locally advanced or metastatic melanoma harboring the... | Inclusion Criteria:
For the dose escalation phase:
* Histologically confirmed diagnosis of locally advanced or metastatic melanoma (stage IIIB to IV per American Joint Committee on Cancer \[AJCC\]). For the dose expansion phase: (i) Histologically confirmed diagnosis of locally advanced or metastatic melanoma (stage I... | 35,278 |
Study Objectives
This is a phase 2 study of investigational drug, durvalumab given in combination with azacitidine (CC-486). The main purpose of this phase 2 study is to assess the antitumor activity of azacitidine in combination with durvalumab patients with microsatellite stable colorectal carcinoma (MSS-CRC), platin... | Inclusion Criteria:
* Able to provide written informed consent.
* Age ≥18 years or ≥20 years for Japanese participants.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Life expectancy of ≥12 weeks
* Have histologically or cytologically-documented, locally-advanced, or metastatic solid malig... | 33,445 |
Study Objectives
The investigational product (IP) HL-085 is an adenosine triphosphate-noncompetitive mitogen activated protein kinase (MEK) inhibitor with a strong selective anti-tumor activity, with a much lower dose than selumetinib. It has been shown strong anti-tumor activities in preclinical studies to treat solid... | Inclusion Criteria:
* Written informed consent must be obtained prior to any clinical trial procedures* Aged 18 years or over.* Must have a pathologically documented solid tumor(s) that has relapsed from, or is refractory to standard treatment, or unable to tolerate toxicities from the SOC/available treatments, or for ... | 37,628 |
Study Objectives
This study evaluates the ability of a prototype intraoperative handheld gamma camera (pIHGC) to image (detect) sentinel lymph nodes (SLNs) in melanoma and breast cancer during surgical excision, as compared to standard of care intraoperative gamma probes (GP). The unit of study in this trial was SNLs r... | INCLUSION CRITERIA
* Malignancy for which sentinel node biopsy with lymphoscintigraphy are indicated as part of the standard of care for tumor staging
* Age 18 or greater.
* Healthy enough for surgery
* Able to understand and willing to sign a written informed consent document.
EXCLUSION CRITERIA
* No exclusion requ... | 15,258 |
Study Objectives
The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well as several parameters of CE-EUS based on time-intensity-curve (TIC) analysi... | Inclusion Criteria:
* Patients diagnosed with solid pancreatic tumor masses, with cytological / histo-logical confirmation
* Patients with or without suspected lymph node involvement are eligible
* Age 18 to 90 years old, men or women
* Signed informed consent for EG-EUS, CE-EUS and FNA biopsy
Exclusion Criteria:
* ... | 23,702 |
Study Objectives
The purpose of this study is to learn fluid from sonohysterography can be used to diagnose endometrial cancer.
Conditions: Endometrial Cancer
Intervention / Treatment:
PROCEDURE: Sonohysterography
| Inclusion Criteria:
* Newly diagnosed early-stage endometrial cancer
Exclusion Criteria:
* Recurrent or persistent endometrial cancer
* Evidence of distant metastases | 3,588 |
Study Objectives
This 4 arm study will evaluate the efficacy and safety of 4 neoadjuvant treatment regimens in female patients with locally advanced, inflammatory or early stage HER2 positive breast cancer. Before surgery, patients will be randomized to one of 4 treatment arms, to receive 4 cycles of a)Herceptin + doce... | Inclusion Criteria:
* female patients, >=18 years of age;
* locally advanced, inflammatory or early stage invasive breast cancer;
* HER2 positive (HER2+++ by IHC or FISH/CISH+).
Exclusion Criteria:
* metastatic disease (Stage IV) or bilateral breast cancer;
* previous anticancer therapy or radiotherapy for any malig... | 29,264 |
Study Objectives
The purpose of this study is to determine whether or not CTCs can be detected in blood samples taken from patients diagnosed with small cell lung cancer. The purpose is to compare CTC analysis to tumor samples to look for differences.
Conditions: Small Cell Lung Cancer
Intervention / Treatment:
| Inclusion Criteria:
* Histological proof of small cell lung cancer with extensive stage disease and have been untreated.
* Must be willing to give and sign informed consent.
* Must be 18 years of age
Exclusion Criteria:
* Less than 18 years of age. | 27,451 |
Study Objectives
This is a prospective randomised controlled trial to assess an intervention of inspection during both phases of colonoscopic examination ( insertion and withdrawal) improve adenoma detection rate when compared to inspection only during withdrawal.
Conditions: Adenoma Colon, Serrated Adenoma
Intervent... | Inclusion Criteria:
* Participants who are referred for a bowel scope screening procedure
Exclusion Criteria:
* Patients lacking capacity to give informed consent
* Pregnant women
* Age less than 55 years
* Uncorrectable coagulopathy
* Patients who are not fit for flexible sigmoidoscopy
* Incomplete procedure | 25,511 |
Study Objectives
This study will evaluate the effect of cabozantinib compared to prednisone on overall survival in men with previously treated metastatic castration-resistant prostate cancer with bone-dominant disease who have experienced disease progression on docetaxel-containing chemotherapy and abiraterone or MDV31... | Inclusion Criteria:
* Histological or cytological diagnosis of castration resistant prostate cancer (serum testosterone less than 50 ng/dL).
* Evidence of bone metastasis related to prostate cancer on bone scans.
* Received prior docetaxel (minimum cumulative dose of 225 mg/m2) and either abiraterone or MDV3100 treatm... | 16,487 |
Study Objectives
This is an observational retrospective cohort study to determine metachronous peritoneal carcinomatosis in a specific subgroup of colon cancer patients, those with a final pathologic exam corresponding to pT4 tumors.
Based on a sample size calculation of 1152 patients, a retrospective review of a thre... | Inclusion Criteria:
* Colon cancer above 15 cm from anal verge
* Curative intent surgery
* Pathologic confirmation of pT4 adenocarcinoma
Exclusion Criteria:
* R2 cancer resection
* Inclusion in other randomized clinical trials
* Pathologic diagnosis of colon cancer other than adenocarcinoma, such as GIST, leiomyosar... | 1,937 |
Study Objectives
The goal of this psychosocial research study is to learn whether a website program called "Tendrils: Sexual Renewal for Women after Cancer " may help female cancer survivors improve their sex lives when used either as a self-help tool or in combination with brief sexual counseling by a health care prof... | Inclusion Criteria:
* Phase I: Woman cancer survivor* Phase I: Speaks and reads English well enough to evaluate the website and participate in a focus group* Phase II: Had breast cancer or a gynecological cancer diagnosed 1 to 5 years previously* Phase II: Has a sexual partner in relationship of at least 6 months' dura... | 18,078 |
Study Objectives
The aim of the project is to clarify whether DLBCL exhibits mutational diversity among different lymph node tumors in one and the same patient. It is desired to find out whether a possible difference between lymph node tumors / tumors can explain why patients who initially (at diagnosis) have the same ... | Inclusion Criteria:
* Diagnosed with DLBCL* Immunochemotherapy (rituximab and CHOP-like chemotherapy) planned and not yet initiated (pretreatment with prednisolone is allowed)* Age ≥ 18 years* More than 1 lymphoma site accessible for biopsy* Patient must consent to permit genetic analysis of their tumor biopsies* Patie... | 19,031 |
Study Objectives
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric properties of the GAH study (CEL-GAH-2011-01). In all cases, only data prior... | Inclusion Criteria:
* Patients who were participating in the GAH study (CEL-GAH-2011-01).
* Patients who have been scheduled to start treatment at a date less than three months after completion of the GAH (CEL-GAH-2011-01) scale in one of these visits: baseline, test-retest or sensitivity to change.
* Patients who giv... | 549 |
Study Objectives
This trial combines trastuzumab and bevacizumab monoclonal antibodies, with ABI-007 and carboplatin, as neoadjuvant therapy in previously untreated locally advanced breast cancers demonstrating HER2 gene amplification. It is hoped that this novel combination will result in increased pathologic response... | Inclusion Criteria:
* Female patients with histologically confirmed adenocarcinoma of the breast or inflammatory breast cancer
* Clinical stage T 1-4, N 0-3, M0
* FISH+ HER2 gene amplified breast cancer
* 18 years or older
* Normal cardiac function
* Performance status 0-2
* Cannot have received any prior chemotherapy... | 1,974 |
Study Objectives
Radiotherapy is the primary treatment modality or an important adjunct treatment for many patients with H\&N carcinoma. Local control is directly related to dose and to the technical accuracy with which the dose is delivered to the target volume. Traditional radiotherapy techniques result in significan... | Inclusion Criteria:
* Squamous cell cancer of head and neck for radical/postoperative radiation therapy
* American Joint Committee on Cancer (AJCC) stage I-IV with M0 and N0-2 disease
* Karnofsky performance status (KPS) >= 70%
Exclusion Criteria:
* M1 or N3 disease
* Ineligibility for radiotherapy
* Recent malignan... | 22,780 |
Study Objectives
This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained usin... | Inclusion Criteria:
* ≥ 18 years
* ECOG 0-2
* Pulmonary neoplasia, confirmed histopathologically or by imaging
* Prognosis evaluated ≥ 1 year by attending MD
* Clinically acceptable lung capacity to undergo radiotherapy
* Initial assessment including history, physical examination, biochemistry, PFT, chest radiograph, ... | 18,416 |
Study Objectives
This community-based randomized trial tested the effects of a social support intervention to increase Chamorro, Samoan, and Tongan women's Pap test behavior and social support among their male spouses or significant others in Southern California.
Conditions: Cervical Cancer
Intervention / Treatment:
... | Inclusion Criteria:
* Women ages 21 to 65
* Of Chamorro, Samoan, and/or Tongan ethnicity
* Has a significant other (married or in a long-term relationship for more than 5 years).
Exclusion Criteria:
* Not a member of one of the churches or clans visited for recruitment | 12,680 |
Study Objectives
The association between radiation exposure and cardiac disease is well recognized, it is not fully understood if there exists an optimal or "safe" radiation dose-volume relationship.
Conditions: Node Positive Breast Cancer
Intervention / Treatment:
RADIATION: Radiation therapy groups
| Inclusion Criteria:
* Women with node positive breast cancer treated with surgery, anthracycline-based or similar cardiotoxic chemotherapy, and regional nodal irradiation between 2000-2007.
Exclusion Criteria:
* Women who have not received anthracycline-based or similar cardiotoxic chemotherapy, and regional nodal i... | 7,762 |
Study Objectives
The purpose of the study is to understand the effect of Metformin on patients with PCOS.
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Intervention / Treatment:
DRUG: Metformin intervention for 12 weeks
| Inclusion Criteria:
* Individuals who are 20 to 40 years old, planning to become pregnant or infertile women.* Individuals who are diagnosed as PCOS according to the revised 2003 Rotterdam diagnostic criteria: if 2 out of 3 criteria are met: 1) Oligo- and/or anovulation; 2) Clinical and/or biochemical signs of hyperand... | 4,341 |
Study Objectives
The purpose of this research study is to learn about the effectiveness of using lower-intensity radiation and chemotherapy to treat human papillomavirus (HPV) associated low-risk oropharyngeal and/or unknown primary squamous cell carcinomas of the head and neck. The cure rate for this type of cancer is... | Inclusion Criteria:
* ≥ 18 years of age* T0-3, N0 to N2c, M0 squamous cell carcinoma of the oropharynx* Biopsy proven squamous cell carcinoma that is HPV and/or p16 positive* ≤ 10 pack-years smoking history or > 5 years of abstinence from smoking* History/physical examination within 8 weeks prior to registration* Radio... | 32,583 |
Study Objectives
The purpose of this study is to evaluate the efficacy and safety of amolimogene, in the treatment of patients with high-grade cervical intraepithelial lesions of the uterine cervix.
Conditions: Uterine Cervical Dysplasia
Intervention / Treatment:
DRUG: Amolimogene, DRUG: Amolimogene, OTHER: Placebo
| Inclusion Criteria:
To be considered for enrollment, patients must:
* Have an abnormal Pap smear (atypical squamous cells of undetermined significance \[ASCUS\], atypical squamous cells, cannot exclude high grade \[ASC-H\], low grade squamous intraepithelial lesion \[LSIL\], high grade squamous intraepithelial lesion ... | 23,428 |
Study Objectives
Currently, there is a lack of patient education materials regarding cytotoxic chemotherapy side effects, research supported treatments, and the utilization of CAM by cancer patients at Penn State Cancer Institute. The investigators aim to develop an educational brochure, which educates patients about t... | Inclusion Criteria:
* Adults with a diagnosis of breast or gastrointestinal cancer, at any stage or progression, who are cytotoxic chemotherapy treatment naïve and initiating treatment or have newly begun cytotoxic chemotherapy within the last 6 weeks. Patients receiving multiple therapy forms, such as immune or humor... | 5,915 |
Study Objectives
Soft tissue sarcoma STS is a group of malignant tumors derived from connective tissue other than bone and cartilage. It can occur in any part of the body at any age, and there is no significant gender difference.According to pathological classification, STS has 19 tissue types and more than 50 disease ... | Inclusion Criteria:
* The patients volunteered to participate in this study and signed the informed consent;* Pathologically confirmed advanced soft tissue sarcomas with at least one measurable lesionMainly including Synovial sarcoma (Synovial sarcoma), Leiomyosarcoma (Leiomyosarcoma), gland Alveolar soft tissue sarcom... | 32,561 |
Study Objectives
The purpose of this study is to determine the safety and effectiveness of a multi-drug regimen (which includes prednisone, vincristine, cytarabine, doxorubicin, 6 mercaptopurine, and methotrexate) which is considered standard treatment for children and young adults with acute lymphoblastic leukemia (AL... | Inclusion Criteria:
* Acute lymphoblastic leukemia, excluding known mature B-cell ALL by the presence of any of the following: surface immunoglobulin, L3 morphology, t(8;14)(q24;q32), t(8;22), or t(2;8).
* Patients with mature B-cell ALL will be removed from the protocol as soon as the diagnosis is made and should be ... | 21,496 |
Study Objectives
The aim of this study is the synergistic effect of cancer ablation and life information rehabilitation therapy on unresectable lung cancer.
Conditions: Small-cell Lung Cancer
Intervention / Treatment:
DEVICE: Cancer ablation, DRUG: Life information rehabilitation therapy
| Inclusion Criteria:
* All standard therapies have failed according to NCCN guidelines or the patient refuses standard therapies
* Body tumor 1-6, with at least one tumor length > 2 cm
* KPS ≥ 70, lifespan > 6 months
* Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ ... | 29,743 |
Study Objectives
Fruquintinib with PD-1 inhibitors (FP) and TAS-102 with bevacizumab (TB) are two common therapies for patients with previous-treated metastatic colorectal cancer (mCRC). However, it's still not clear that which therapy can bring better prognosis. Our study sought to investigate the efficacy and safety ... | Inclusion Criteria:
* Has histologically confirmed unresectable adenocarcinoma of the colon or rectum (all other histological types are excluded).* Have progressed from at least 2 lines of standard treatment,including fluoropyrimidines, irinotecan, oxaliplatin, with or without targeted drugs, like bevacizumab and cetux... | 18,112 |
Study Objectives
The Prometra Pump is approved by the FDA for use in the United States. The purpose of this study is to collect long-term safety data on the Prometra Pump.
Conditions: Chronic Pain, Cancer Pain, Intractable Pain, Back Pain
Intervention / Treatment:
DEVICE: Prometra Programmable Intrathecal Infusion Pu... | Inclusion Criteria:
* Patient meets at least one of the following:
* is suffering from malignant pain (i.e., cancer pain)
* has chronic, non-malignant pain
* subject was enrolled in PUMP I or PUMP II study and chooses to participate in this Post-Approval study
* Patient with an existing implantable pump fo... | 2,273 |
Study Objectives
The purpose of this study is to obtain an estimate of the objective response rate (ORR) of AMG 479 in patients with recurrent platinum-sensitive ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma failing frontline chemotherapy.
Conditions: Ovarian Neoplasms
Intervention / ... | Inclusion Criteria:
* Histologically-confirmed ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma. Baseline paraffin embedded tissue from the patient's primary diagnosis is requested before study enrollment and should be forwarded to the designated central laboratory. In patients with measu... | 4,679 |
Study Objectives
This study is being done to compare standard radiation therapy with hypofractionated radiation therapy for patients with newly diagnosed glioblastoma
Conditions: Glioblastoma
Intervention / Treatment:
RADIATION: Hypofractionated radiation therapy, RADIATION: Standard radiation therapy
| Inclusion Criteria:
* Newly-diagnosed, histologically proven, intracranial glioblastoma or gliosarcoma treated with maximal safe resection, which may be biopsy alone if resection is not possible.* History and physical examination, including neurological examination, within 14 days prior to randomization.* Age between 1... | 14,360 |
Study Objectives
The purpose of this study is to evaluate the safety and pharmacokinetics and assess the immunogenicity and effectiveness of AGS-16C3F in subjects with renal cell cancer (RCC).
Conditions: Carcinoma, Renal Cell, Renal Cell Carcinoma of Papillary Histology, Renal Cell Carcinoma With Clear Cell Histology... | Inclusion Criteria:
* Dose determination cohorts: Histologically confirmed diagnosis of metastatic RCC of either clear cell or non-clear histology.
* Tumors with clear cell histology: subject must have progressed after at least one anti-vascular endothelial growth factor receptor (anti-VEGFR) therapy
* Tumors wit... | 20,935 |
Study Objectives
Basal cell carcinoma (BCC) is the most common malignant skin lesion in white adults. It is a slow-growing tumour which despite low metastatic potential may cause significant local tissue destruction and patient morbidity. Methyl aminolevulinate cream plus photodynamic therapy (MAL-PDT) for BCC is curre... | Inclusion Criteria:
* male/female above 18 years of age
* written informed consent
* 1 or more primary histologically verified BCC, clinically assessed as of either superficial of nodular type
Exclusion Criteria:
* pregnancy
* breastfeeding
* Gorlin's syndrome
* porphyria
* xeroderma pigmentosum
* history of arsenic... | 4,645 |
Study Objectives
A prospective observational longitudinal study of 464 patients was performed between 2010 and 2015. Patients with invasive ductal carcinoma (IDC) and ductal carcinoma in situ associated to invasive ductal carcinoma (DCIS +IDC) were included and analyzed.
Conditions: Outcome of Breast Cancer
Intervent... | Inclusion Criteria:
* Patients with invasive ductal carcinoma of the breast
* Patients who received surgery for primary invasive breast cancer between 2010 and 2015
Exclusion Criteria:
* Patients with metastasis at the diagnostic | 23,410 |
Study Objectives
This is the first study in which TAK-441 is administered to humans. The patient population will consist of adults aged 18 or older who have advanced nonhematologic malignancies and for whom standard treatment is no longer effective or does not offer curative or life-prolonging potential. Following comp... | Inclusion Criteria:
Each patient must meet all of the following inclusion criteria to be enrolled in the study:
* Male or female 18 years or older
* Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2
* Diagnosis of a nonhematologic malignancy for which standard treatment is no longer effective or doe... | 16,675 |
Study Objectives
The purpose of our study is to recruit and treat 96 men diagnosed with prostate cancer and scheduled for a prostatectomy with a capsule form of either purified isoflavones or placebo for a 3-6 week period to see if we can slow down the rate of prostate cancer growth. A placebo is a pill or something th... | Inclusion Criteria:
* Diagnosis of localized prostate cancer (PCa), based on pathological assessment from biopsy specimens
* No prior or current therapy for PCa or history of cancer except non-melanoma skin cancer
* Scheduled for prostatectomy between 3- 6 weeks (+/-3 days) after start of study agent
* No known histor... | 8,211 |
Study Objectives
This 2-phase study will determine the safety of treating patients with prostate cancer with the genetically engineered HyperAcute-Prostate cancer vaccine. It will establish the proper vaccine dose and will examine side effects and potential benefits of the treatment. The vaccine contains killed prostat... | Inclusion Criteria:
* Phase I and Phase II Arm A: A histological diagnosis of prostate cancer with evidence of metastatic disease by CT scan or bone scan. Phase II, Arm B: Evidence of hormone refractive progressive disease by increasing PSA only.
* For patients enrolling in Phase II, Arm B: refractory to hormone thera... | 37,742 |
Study Objectives
To discover if the adding of a coxib increases the efficacy of the Aromasine.
Conditions: Metastatic Breast Cancer
Intervention / Treatment:
DRUG: placebo, DRUG: Celecoxib, DRUG: Exemestane
| Inclusion Criteria:
* Femal patient aged > 18 years
* Histologically proven breast cancer
* Menopausal patient according to the following definition:
* amenorrhoea > 1 year or menopause affirmed by a rate of oestradiol or hypophyseal gonadotrophin
* surgical ovariectomy
* treatment by LHRH analog
* ovarian su... | 27,024 |
Study Objectives
Gastrointestinal stromal tumors (GISTs) are associated with a dismal prognosis in localized and advanced phase with a major resistance to conventional chemotherapy agents. Virtually all malignant GISTs actually harbor activating mutations of the KIT pathway in the tumor cells, leading to ligand-indepen... | Inclusion Criteria:
* Patients 18 years of age or over.* Histologically documented diagnosis of malignant GIST.* Immunohistochemical documentation of c-kit (CD117) expression either by the primary tumor or metastases using the DAKO assay.* Performance status 0,1, 2, 3 (ECOG)* Adequate end organ function, defined as the... | 30,315 |
Study Objectives
Hysterectomy for benign indication is one of the most common surgical procedures in women. Numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic) hysterectomies is increasing.
This study will compare a range of clinical ... | Inclusion Criteria:
* benign indication for vaginal hysterectomy (e.g., abnormal uterine bleeding, fibroids, atypical endometrial hyperplasia)
* clinical exam indicates vaginal hysterectomy is feasible
* no major concomitant surgery
* able to complete questionnaires in German
Exclusion Criteria:
* uterine malignancy... | 32,028 |
Study Objectives
Purpose:
This randomized phase II trial evaluated whether the combination of cisplatin and paclitaxel plus All-trans retinoic acid (ATRA) increases Response rate (RR) and Progression-free survival (PFS) in patients with advanced Non-small cell lung cancer (NSCLC) with an acceptable toxicity profile an... | Inclusion Criteria:
* Stage III B and IV NSCLC
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
* No prior cytotoxic chemotherapy for NSCLC
* Age ≥18 years, adequate laboratory measurements
* Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST)
* Life expectancy of... | 37,552 |
Study Objectives
The objective of this study was to evaluate the safety profile of ELIGARD® in ethnic Asian prostate cancer patients.
Conditions: Prostate Cancer
Intervention / Treatment:
DRUG: Leuprolide
| Inclusion Criteria:
* A patient for whom the physician has decided to initiate treatment with a Luteinizing Hormone Releasing Hormone (LHRH) agonist in standard clinical practice
* Biopsy-proven prostate adenocarcinoma
* Locally advanced prostate cancer with biochemical relapse radical prostatectomy and/or radiotherap... | 22,064 |
Study Objectives
To measure arm function and quality of life of mastectomy patients.
Conditions: Breast Cancer
Intervention / Treatment:
PROCEDURE: Arm exercises., PROCEDURE: Arm Exercises
| Inclusion Criteria:
* Patients who have been referred from UNMH to CRTC for further treatment following mastectomy/lumpectomy surgery.
Exclusion Criteria:
* Not specified | 33,005 |
Study Objectives
This is a Phase II, nonrandomized multicenter study designed to evaluate time to progression and response proportion of patients with advanced or metastatic transitional cell carcinoma of bladder receiving 6 cycles of gemcitabine, carboplatin and sorafenib and then maintenance sorafenib.
Conditions: B... | Inclusion Criteria:
* Histologic documentation of diagnosis of transitional cell carcinoma of the bladder, urethra, ureter, or renal pelvis
* Unresectable, locally advanced or metastatic disease
* CrCl ≥ 60 ml/min or serum creatinine < 1.5
* ≥ 4 weeks since prior RT
* ECOG Performance Status of 0 or 1 (Appendix I)
* A... | 37,761 |
Study Objectives
The aim of the study is a medico-economic evaluation to estimate a cost differential between three modalities of Intensity-Modulated Radiation Therapy for cancers of the prostate, cervix and anal canal with pelvic lymph node irradiation : treatment with helical Tomotherapy and dynamic arc therapy using... | Inclusion Criteria:
* WHO performance index ≤ 2
* Age > 18 years
* histologically proven carcinoma: Anal canal cancer locally advanced (> 4 cm and / or N1 to N3) under irradiation on pelvic and inguinal lymph nodes with concurrent chemotherapy. The boost with brachytherapy are accepted Prostate cancer with pelvic lymp... | 30,423 |
Study Objectives
This study aims to evaluate the prognostic value of circulating tumour cells (CTC) in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy due to gastrointestinal cancers that have spread to the peritoneum.
Conditions: Circulating Tumor Cell, Peritoneal Metastases, H... | Inclusion Criteria:
* Peritoneal metastases being treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Exclusion Criteria:
* None | 37,555 |
Study Objectives
To determine the safety and immunogenicity profile of two (2) different doses of the vaccine DPX-0907 to treat breast, ovarian and prostate cancer.
Conditions: Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms
Intervention / Treatment:
BIOLOGICAL: DPX-0907 consists of 7 tumor-specific HLA-A2-r... | Inclusion Criteria:
* Patients with stage III or IV ovarian cancer who have completed a course of platinin-based cytotoxic therapy after debulking surgery with evidence of a complete or partial response by radiological imaging. Patients with metastatic ovarian cancer who have stable disease for greater than 3 months a... | 13,743 |
Study Objectives
The EndoRotor® is intended for use (USA labeling) in endoscopic procedures by a trained gastroenterologist to resect and remove tissue, not intended for biopsy, of the gastrointestinal (GI) system including post-endoscopic mucosal resection (EMR) tissue persistence with a scarred base and residual tiss... | Inclusion Criteria:
* Subjects aged ≥18 to ≤85 years.* At least one recurrent flat or sessile colorectal lesion measuring up to 6 cm in diameter and/or length.* Presence of recurrent flat or sessile lesion where the EndoRotor may be used to resect recurrent neoplasia.* Favorable anatomy that allows the investigator to ... | 4,146 |
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