Datasets:

rahul24raj
/

lysos-amr-stage2-reasoning

task stringclasses 10 values	split stringclasses 1 value	prompt stringlengths 100 2.13k	response stringlengths 61 1.5k	messages stringlengths 266 2.78k
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environm...	The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emergence of vancomycin-re...	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornl...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: Clinicians nowadays are confronted with an epidemic of multidrug-resistant (MDR) Acinetobacter infections and are forced to consider every treatment alternative, including older antibiotic agent...	Clinicians nowadays are confronted with an epidemic of multidrug-resistant (MDR) Acinetobacter infections and are forced to consider every treatment alternative, including older antibiotic agents, not conventionally used. This review aimed to evaluate the published evidence on the antimicrobial activity and clinical ef...	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: Clinicians nowadays are confronted with an epidemic of multidrug-resistant (MDR) Acinetobacter infections and are forced to consider every treatment alternative, i...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: High-throughput whole genome sequencing has unlocked a multitude of possibilities enabling members of the Neisseria genus to be examined with unprecedented detail, including the human pathogens ...	High-throughput whole genome sequencing has unlocked a multitude of possibilities enabling members of the Neisseria genus to be examined with unprecedented detail, including the human pathogens Neisseria meningitidis and Neisseria gonorrhoeae.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: High-throughput whole genome sequencing has unlocked a multitude of possibilities enabling members of the Neisseria genus to be examined with unprecedented detail,...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of ADC-68?	A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of ADC-68?"}, {"role": "assistant", "content": "A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii."}]
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: This study aims to investigate the development of secondary bacterial infection and risk factors associated with it in critical COVID-19 patients, and to identify the most common pathogen groups...	This study aims to investigate the development of secondary bacterial infection and risk factors associated with it in critical COVID-19 patients, and to identify the most common pathogen groups in them. All the cohort studies were retrieved from Scopus, Google Scholar, Web of Science, and MEDLINE from the inception of...	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: This study aims to investigate the development of secondary bacterial infection and risk factors associated with it in critical COVID-19 patients, and to identify ...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of SHV-129?	SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of SHV-129?"}, {"role": "assistant", "content": "SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates."}]
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Escherichia coli acrA?	AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Escherichia coli acrA?"}, {"role": "assistant", "content": "AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli."}]
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of CTX-M-138?	CTX-M-138 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of CTX-M-138?"}, {"role": "assistant", "content": "CTX-M-138 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which d...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide. The current antibacterial arsenal is becoming obsolete, and the pace of dr...	The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide. The current antibacterial arsenal is becomi...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Horizontal gene transfer: building the web of life.	Horizontal gene transfer (HGT) is the sharing of genetic material between organisms that are not in a parent-offspring relationship. HGT is a widely recognized mechanism for adaptation in bacteria and archaea. Microbial antibiotic resistance and pathogenicity are often associated with HGT, but the scope of HGT extends ...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Horizontal gene transfer: building the web of life."}, {"role": "assistant", "content": "Ho...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant ...	Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections .	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: Carbapenems are potent members of the \u03b2-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negati...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: A global medical crisis is unfolding as antibiotics lose effectiveness against a growing number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to the rapid spre...	A global medical crisis is unfolding as antibiotics lose effectiveness against a growing number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to the rapid spread of resistance, yet the transmission dynamics of genes that confer antibiotic resistance are poorly understood.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: A global medical crisis is unfolding as antibiotics lose effectiveness against a growing number of bacterial pathogens. Horizontal gene transfer (HGT) contributes ...
drug_history	train	Instructions: Briefly summarize the discovery / development history of the named drug. Question: When and how was Vancomycin discovered?	History Vancomycin was first isolated in 1953 by a research team lead by chemist Edmund Kornfeld at Eli Lilly, from a soil sample provided by missionary William M. Bouw. The sample had been collected in 1952 within a forest on the island of Borneo, after Bouw took over collection duties from the Reverend William W. Con...	[{"role": "user", "content": "Instructions: Briefly summarize the discovery / development history of the named drug.\nQuestion: When and how was Vancomycin discovered?"}, {"role": "assistant", "content": "History\nVancomycin was first isolated in 1953 by a research team lead by chemist Edmund Kornfeld at Eli Lilly, fro...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challen...	Neisseria gonorrhoeae has developed antimicrobial resistance (AMR) to all drugs previously and currently recommended for empirical monotherapy of gonorrhoea. In vitro resistance, including high-level, to the last option ceftriaxone and sporadic failures to treat pharyngeal gonorrhoea with ceftriaxone have emerged. In r...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria g...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: Riboswitches sense specific cellular metabolites, leading to messenger RNA conformational changes that regulate downstream genes. Here, we review the three known prequeosine1 (preQ1) riboswitch ...	Riboswitches sense specific cellular metabolites, leading to messenger RNA conformational changes that regulate downstream genes. Here, we review the three known prequeosine1 (preQ1) riboswitch classes, which encompass five gene-regulatory motifs derived from distinct consensus models of folded RNA pseudoknots.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: Riboswitches sense specific cellular metabolites, leading to messenger RNA conformational changes that regulate downstream genes. Here, we review the three known p...
drug_history	train	Instructions: Briefly summarize the discovery / development history of the named drug. Question: When and how was Staphylococcus aureus discovered?	History Discovery In 1880, Alexander Ogston, a Scottish surgeon, discovered that Staphylococcus can cause wound infections after noticing groups of bacteria in pus from a surgical abscess during a procedure he was performing. He named it Staphylococcus after its clustered appearance evident under a microscope. Then, ...	[{"role": "user", "content": "Instructions: Briefly summarize the discovery / development history of the named drug.\nQuestion: When and how was Staphylococcus aureus discovered?"}, {"role": "assistant", "content": "History\n\n\nDiscovery\nIn 1880, Alexander Ogston, a Scottish surgeon, discovered that Staphylococcus ca...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of PDC-482?	Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-482.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of PDC-482?"}, {"role": "assistant", "content": "Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-482."}]
drug_indication	train	Instructions: Describe the medical uses of the named drug. Question: What is Gentamicin used to treat?	Medical uses Gentamicin is active against a wide range of bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Serratia, and the Gram-positive Staphylococcus. Gentamicin is used in the treatment of respiratory tract infectio...	[{"role": "user", "content": "Instructions: Describe the medical uses of the named drug.\nQuestion: What is Gentamicin used to treat?"}, {"role": "assistant", "content": "Medical uses\nGentamicin is active against a wide range of bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Escher...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of CMY-185?	We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of CMY-185?"}, {"role": "assistant", "content": "We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC en...
drug_overview	train	Instructions: Give a concise but complete overview of the named antibiotic — class, indications, mechanism, key resistance issues. Question: Summarize what's important about Cefuroxime.	Cefuroxime, sold under the brand name Zinacef among others, is a second-generation cephalosporin antibiotic used to treat and prevent a number of bacterial infections. These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme disease. It is used by mouth or by injection into a vein o...	[{"role": "user", "content": "Instructions: Give a concise but complete overview of the named antibiotic \u2014 class, indications, mechanism, key resistance issues.\nQuestion: Summarize what's important about Cefuroxime."}, {"role": "assistant", "content": "Cefuroxime, sold under the brand name Zinacef among others, i...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline?	These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline?"}, {"role": "assistant", "content": "These pepQ/Rv2535c mutations increase...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Clinical efficacy, safety and pharmacokinetics of novel β-lactam/β-lactamase inhibitor combinations: a systematic review.	BACKGROUND: Antimicrobial resistance is a global public health threat that requires urgent solutions. One strategy to decrease resistance of Gram-negative bacteria (GNB) to β-lactam antibiotics (BL) is their combination with β-lactamase inhibitors (BLI). OBJECTIVES: This systematic review analyses the outcomes, safety ...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Clinical efficacy, safety and pharmacokinetics of novel \u03b2-lactam/\u03b2-lactamase inhi...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Alternative drugs for the treatment of gonococcal infections: old and new.	INTRODUCTION: The rise in antibiotic resistance to N. gonorrhoeae poses a substantial threat to effective gonorrhea treatment. Historical progression of resistance from sulfonamides to the more recent declines in efficacy of fluoroquinolones and susceptibilities of ceftriaxone highlight the urgent need for novel therap...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Alternative drugs for the treatment of gonococcal infections: old and new."}, {"role": "ass...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A?	Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A?"}, {"role": "assistant", "content": "Sequence variants of Enterococcus faecium elongation fa...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: The emergence and spread of antibiotic resistance is one of the biggest challenges in public health. There is an urgent need to discover novel agents against the occurrence of multidrug-resistan...	The emergence and spread of antibiotic resistance is one of the biggest challenges in public health. There is an urgent need to discover novel agents against the occurrence of multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: The emergence and spread of antibiotic resistance is one of the biggest challenges in public health. There is an urgent need to discover novel agents against the o...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: The occurance and prevalence of multidrug-resistant tuberculosis poses a serious threat to the global tuberculosis control. Ethambutol (EMB) is one of the first-line anti-tuberculosis drugs, whi...	The occurance and prevalence of multidrug-resistant tuberculosis poses a serious threat to the global tuberculosis control.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: The occurance and prevalence of multidrug-resistant tuberculosis poses a serious threat to the global tuberculosis control. Ethambutol (EMB) is one of the first-li...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Erm(37)?	Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Erm(37)?"}, {"role": "assistant", "content": "Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this ...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Translational control of antibiotic resistance.	Many antibiotics available in the clinic today directly inhibit bacterial translation. Despite the past success of such drugs, their efficacy is diminishing with the spread of antibiotic resistance. Through the use of ribosomal modifications, ribosomal protection proteins, translation elongation factors and mistranslat...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Translational control of antibiotic resistance."}, {"role": "assistant", "content": "Many a...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant threats, none of ...	Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant threats, none of the available therapies have been shown to consistently reduce mortality or improve patient outcomes in clinical trials.	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of the top-priority pathogens for new antibiotic development. Unlike other antibio...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of TEM-151?	TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of TEM-151?"}, {"role": "assistant", "content": "TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli."}]
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of CMY-101?	CMY-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of CMY-101?"}, {"role": "assistant", "content": "CMY-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did n...
abstract_qa	train	Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences. Abstract: Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop resistance mechanisms against a...	Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop resistance mechanisms against a variety of clinically relevant antibiotics. In this comprehensive review, we carefully dissect the resistance mechanisms empl...	[{"role": "user", "content": "Instructions: Read the research abstract and identify the key antibacterial / AMR-related finding in 2-3 sentences.\nAbstract: Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop ...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of CMY-94?	CMY-94 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of CMY-94?"}, {"role": "assistant", "content": "CMY-94 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not...
drug_history	train	Instructions: Briefly summarize the discovery / development history of the named drug. Question: When and how was Levofloxacin discovered?	History Levofloxacin is a third-generation fluoroquinolone, being one of the isomers of ofloxacin, which was a broader-spectrum conformationally locked analog of norfloxacin; both ofloxacin and levofloxaxin were synthesized and developed by scientists at Daiichi Seiyaku. The Daiichi scientists knew that ofloxacin was r...	[{"role": "user", "content": "Instructions: Briefly summarize the discovery / development history of the named drug.\nQuestion: When and how was Levofloxacin discovered?"}, {"role": "assistant", "content": "History\nLevofloxacin is a third-generation fluoroquinolone, being one of the isomers of ofloxacin, which was a b...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of OXA-140?	OXA-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of OXA-140?"}, {"role": "assistant", "content": "OXA-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did n...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide?	Mutations in ppsD can contribute to or confer resistance to pyrazinamide.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide?"}, {"role": "assistant", "content": "Mutations in ppsD can contribute to or confer r...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of OXA-336?	OXA-336 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of OXA-336?"}, {"role": "assistant", "content": "OXA-336 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did n...
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of OXA-18?	OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia.	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of OXA-18?"}, {"role": "assistant", "content": "OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia."}]
resistance_gene_explain	train	Instructions: Explain how the named bacterial gene confers antibiotic resistance. Question: What is the resistance mechanism of Escherichia coli LamB?	LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-r...	[{"role": "user", "content": "Instructions: Explain how the named bacterial gene confers antibiotic resistance.\nQuestion: What is the resistance mechanism of Escherichia coli LamB?"}, {"role": "assistant", "content": "LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. Wh...
abstract_summarize	train	Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication. Article title: Exploring norfloxacin analogs in combating antimicrobial resistance: design, mechanistic insights and structure activity r...	Norfloxacin (NF), a fluoroquinolone (FN) antibiotic, has garnered significant attention for its broad-spectrum antimicrobial activity, particularly against gram-negative bacteria. This review article explores the structural modifications and derivatives of NF that enhance its efficacy and broaden its antimicrobial spec...	[{"role": "user", "content": "Instructions: Given the title of a research article, summarize what the article would conclude about its topic, in 3-6 sentences. Be specific about mechanism / outcome / implication.\nArticle title: Exploring norfloxacin analogs in combating antimicrobial resistance: design, mechanistic in...