pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
25,445,090 | Is lymphocyte inhibition compromised in mesenchymal stem cells from psoriatic skin? | {
"contexts": [
"Psoriasis is a chronic inflammatory skin disorder associated with a host of immune abnormalities. Mesenchymal stem cells (MSCs) have immunosuppressive properties and, in earlier studies, we found that the bone marrow MSCs of patients with psoriasis exhibit abnormal cytokine secretion. Since MSCs ... | This study demonstrated abnormalities in MSCs derived from psoriatic skin lesions. We suggest that the attenuated inhibitory effect on T-cell proliferation might be one of the pathogenic mechanisms of psoriasis. | yes |
25,441,651 | Does learning trajectories of children with special health care need across the severity spectrum? | {
"contexts": [
"A significant proportion of school-aged children experience special health care needs (SCHN) and seek care from pediatricians with a wide range of condition types and severity levels. This study examines the learning pathways of children with established (already diagnosed at school entry) and em... | Even children with less complex SCHN are at risk for academic failure. Early identification, together with integrated health and educational support, may promote stronger pathways of educational attainment for these children. Achieving these better outcomes will require the involvement of both educational and health pr... | yes |
25,427,715 | Does deep Sequencing the microRNA profile in rhabdomyosarcoma reveal down-regulation of miR-378 family members? | {
"contexts": [
"Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. MicroRNAs (miRNAs) represent a class of short, non-coding, regulatory RNAs which play a critical role in different cellular processes. Altered miRNA levels have been reported in hum... | MiR-378a-3p may function as a tumour suppressor in RMS and the restoration of its expression would be of therapeutic benefit in RMS. Furthermore, the role of epigenetic modifications in RMS deserves further investigations. | yes |
25,442,707 | Does health indicators associated with fall among middle-aged and older women enrolled in an evidence-based program? | {
"contexts": [
"Evidence-based fall prevention programs primarily attract older women, who are increasingly burdened by fall-related injuries. However, little is known about the relationship between older female participants' baseline health status and self-reported falls over the course of fall prevention inter... | Findings have implications for identifying at-risk older women upon enrollment, expanding the reach of AMOB/VLL, and leveraging AMOB/VLL to refer participants to other evidence-based exercise, disease management, and mental health interventions. | yes |
25,442,704 | Do women know best -- findings from a thematic analysis of 5,214 surveys of abortion care experience? | {
"contexts": [
"Patient experience is an essential component of quality care. Few studies have comprehensively evaluated patient experiences of abortion care. The objectives of this study were to describe women's experiences of abortion care in their own words, and to determine themes across patient experiences.... | This analysis highlights specific areas of abortion care that influence patients' experience. The few women who were disappointed by care in the clinic tended to fault readily modifiable clinical factors, and provided suggested areas of improvement to enhance positive experiences related to their abortion care. | yes |
25,442,705 | Does unit support protect against sexual harassment and assault among national guard soldiers? | {
"contexts": [
"Despite concerns about increased sexual harassment and assault after the 2013 legislation repealing the ban on women in combat, little research has examined military factors that could prevent sexual harassment and assault during deployment. This study examined whether unit support, which reflect... | A substantial proportion of men and women reported sexual harassment/assault. Greater unit support was associated with diminished odds of sexual harassment/assault during deployment. Programming designed to improve unit cohesion has the potential to reduce sexual harassment and assault. | yes |
25,433,496 | Does the T-box transcription factor Brachyury promote renal interstitial fibrosis by repressing E-cadherin expression? | {
"contexts": [
"Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brachyury, an evolutionarily conserved transcription factor, was recently identified as an i... | Our results demonstrate for the first time that Brachyury plays an important role in regulating TGF-β1-mediated renal EMT and could be an attractive target for progression of renal disease therapies. | yes |
25,429,607 | Does pneumonia Pathogen Characterization be an Independent Determinant of Hospital Readmission? | {
"contexts": [
"Hospital readmissions for pneumonia occur often and are difficult to predict. For fiscal year 2013, the Centers for Medicare & Medicaid Services readmission penalties have been applied to acute myocardial infarction, heart failure, and pneumonia. However, the overall impact of pneumonia pathogen ... | Readmission after hospitalization for pneumonia is relatively common and is related to pneumonia pathogen characterization. Pneumonia attributed to potentially antibiotic-resistant bacteria is associated with an increased risk for 90-day readmission, whereas culture-negative pneumonia is associated with lower risk for ... | yes |
25,427,291 | Does anemia on admission predict short- and long-term outcomes in patients with acute ischemic stroke? | {
"contexts": [
"It is still debatable whether anemia predicts stroke outcome.",
"To describe the characteristics of patients with acute ischemic stroke (AIS) and anemia and identify whether hemoglobin status on admission is a prognostic factor of AIS outcome.",
"All 2439 patients of the Acute Stroke Regi... | Anemia is common among AIS patients and is associated with cardiovascular comorbidities. Low hemoglobin status independently predicts short and long-term mortality. | yes |
25,444,002 | Does obstructive sleep apnea syndrome increase pedestrian injury risk in children? | {
"contexts": [
"To evaluate pedestrian behavior, including reaction time, impulsivity, risk-taking, attention, and decision-making, in children with obstructive sleep apnea syndrome (OSAS) compared with healthy controls.",
"Using a case control design, 8- to 16-year-olds (n = 60) with newly diagnosed and unt... | Results suggest OSAS may have significant consequences on children's daytime functioning in a critical domain of personal safety, pedestrian skills. Children with OSAS appeared to have greater impulsivity when crossing streets. Results highlight the need for heightened awareness of the consequences of untreated sleep d... | yes |
25,436,022 | Is implementation of continuous capnography associated with a decreased utilization of blood gases? | {
"contexts": [
"Capnography provides a continuous, non-invasive monitoring of the CO2 to assess adequacy of ventilation and provide added safety features in mechanically ventilated patients by allowing for quick identification of unplanned extubation. These monitors may allow for decreased utilization of blood g... | Continuous capnography resulted in a significant savings over a 6-month period by decreasing the utilization of blood gas measurements. | yes |
25,440,044 | Does blood PGC-1α Concentration predict Myocardial Salvage and Ventricular Remodeling After ST-segment Elevation Acute Myocardial Infarction? | {
"contexts": [
"Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a metabolic regulator induced during ischemia that prevents cardiac remodeling in animal models. The activity of PGC-1α can be estimated in patients with ST-segment elevation acute myocardial infarction. The aim of the pr... | Baseline PGC-1α expression and an attenuated systemic response after acute myocardial infarction are associated with greater myocardial salvage and predict less ventricular remodeling. | yes |
25,448,997 | Does endoscopic medial orbital fat decompression for proptosis in type 1 grave orbitopathy? | {
"contexts": [
"To describe the surgical technique for endoscopic medial orbital fat decompression in type 1 (lipogenic) Graves orbitopathy and report outcomes.",
"Retrospective interventional case review.",
"We reviewed 108 patients (206 orbits) with inactive, type 1 Graves orbitopathy without diplopia,... | Endoscopic medial orbital fat decompression may be an effective technique for proptosis in selected patients with type 1 Graves orbitopathy and is associated with a low rate of surgically induced diplopia. | yes |
25,433,272 | Does lidocaine potentiate the deleterious effects of triamcinolone acetonide on tenocytes? | {
"contexts": [
"Local anesthetics are commonly used for the treatment of a variety of tendinopathies in combination with corticosteroids injection. The goal of this study was to evaluate the effects of lidocaine and triamcinolone acetonide (TA) on cultured rat tenocytes and to determine whether there is a synerg... | Our data provide evidence of the detrimental effects of these drugs on tendon tissues. Injection of TA in combination with 1% lidocaine should be used with caution. | yes |
25,433,270 | Is pKCε a negative regulator of PVAT-derived vessel formation? | {
"contexts": [
"Vessel formation is a crucial event in tissue repair after injury. Thus, one assumption of innovative therapeutic approaches is the understanding of its molecular mechanisms. Notwithstanding our knowledge of the role of Protein Kinase C epsilon (PKCε) in cardio-protection and vascular restenosis,... | PKCε negatively interferes with vessel progenitor differentiation via interaction with PAK-1. | yes |
25,426,379 | Does topical bFGF improve Secondary Lymphedema through Lymphangiogenesis in a Rat Tail Model? | {
"contexts": [
"Secondary lymphedema is a common complication of cancer therapy, but options for treating lymphedema are essentially ineffective and limited. On the contrary, lymphangiogenic growth factors accelerate lymphangiogenesis and improve lymphedema.",
"Rat tail models of lymphedema were assigned to ... | Topical bFGF induces lymphangiogenesis and improves lymphedema in the rat tail model. | yes |
25,441,175 | Is elevated serum creatine phosphokinase associated with mortality and inotropic requirement in critically injured adults? | {
"contexts": [
"Hemeproteins such as free myoglobin can undergo autoxidation and catalyse lipid peroxidation, increasing oxidative stress. Creatine phosphokinase (CPK) elevation is a marker for free myoglobin after myocyte damage. Since oxidative injury is a key mechanism of injury-related organ dysfunction, we ... | In critically injured patients, elevated serum CPK level is independently associated with mortality, need for inotropic medication, and duration of inotropic support. This study is the first to evaluate the relationship of CPK level and mortality in addition to surrogate measures of shock in a population of critically ... | yes |
25,441,253 | Does thalidomide control adipose tissue inflammation associated with high-fat diet-induced obesity in mice? | {
"contexts": [
"Immunosuppressant agents modulate the activity of the immune system and control adipose tissue inflammatory responses associated with obesity. Controlling adipose tissue inflammation represents an interesting option for inhibiting the low-grade inflammatory state in obese subjects and for prevent... | Our results suggest that drugs that can modulate the inflammatory status as well as control adipose tissue expansion could represent an interesting approach in the management of obesity, highlighting the need for further development of such compounds. | yes |
25,422,774 | Does mild-to-moderate intensity exercise improve cardiac autonomic drive in type 2 diabetes? | {
"contexts": [
"The aim of the present study was to determine the effect of moderate aerobic exercise on cardiac autonomic function in type 2 diabetic patients.",
"Heart rate variability of 20 patients with type 2 diabetes was assessed. Resting electrocardiogram for the heart rate variability analysis at spo... | These data suggest that three times per week moderate intensity aerobic exercise for 6 months improves cardiac rhythm regulation as measured by heart rate variability in type 2 diabetic patients. | yes |
25,422,777 | Is severity of hearing impairment positively associated with urine albumin excretion rate in patients with type 2 diabetes? | {
"contexts": [
"To identify risk factors for hearing impairment among patients with type 2 diabetes mellitus.",
"A total of 68 patients with type 2 diabetes were enrolled between March and September of 2011. Pure-tone auditory tests were carried out for each patient at the following speech frequencies: 250; ... | The present study showed increased albuminuria was positively associated with the severity of hearing impairment among patients with type 2 diabetes. Screening for hearing impairment in diabetic patients who develop albuminuria might provide early detection of hearing impairment. | yes |
25,438,677 | Are in Rasmussen encephalitis , hemichannels associated with microglial activation linked to cortical pyramidal neuron coupling : a possible mechanism for cellular hyperexcitability? | {
"contexts": [
"Rasmussen encephalitis (RE) is a rare but devastating condition, mainly in children, characterized by sustained brain inflammation, atrophy of one cerebral hemisphere, epilepsy, and progressive cognitive deterioration. The etiology of RE-induced seizures associated with the inflammatory process r... | In RE, these results support the notion that a possible mechanism for cellular hyperexcitability may be related to increased intercellular coupling from pannexin linked to increased microglial activation. Such findings suggest that a possible antiseizure treatment for RE may involve the use of gap junction blockers. | yes |
25,447,991 | Do genome-wide ancestry patterns in Rapanui suggest pre-European admixture with Native Americans? | {
"contexts": [
"Rapa Nui (Easter Island), located in the easternmost corner of the Polynesian Triangle, is one of the most isolated locations on the planet inhabited by humans. Archaeological and genetic evidence suggests that the island was first colonized by Polynesians around AD 1200, during their eastward ex... | These genetic results can be explained by one or more pre-European trans-Pacific contacts. | yes |
25,430,410 | Are serum neutrophil gelatinase-associated lipocalin levels correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome? | {
"contexts": [
"Neutrophil gelatinase-associated lipocalin (NGAL) is a novel inflammatory marker that is released from neutrophils. In this study, we evaluated the correlation between serum NGAL level and clinical and angiographic risk scores in patients diagnosed with non-ST elevation acute coronary syndrome (N... | NGAL level was positively correlated with lesion complexity and severity of coronary artery disease in patients with NSTE-ACS. Serum NGAL levels on admission are associated with increased burden of atherosclerosis in patients with NSTE-ACS. | yes |
25,441,577 | Does early tracheostomy in trauma patients save time and money? | {
"contexts": [
"Patients suffering traumatic brain and chest wall injuries are often difficult to liberate from the ventilator yet best timing of tracheostomy remains ill-defined. While prior studies have addressed early versus late tracheostomy, they generally suffer from the use of historical controls, which c... | In the current era of increased health-care costs, early tracheostomy significantly decreased both pulmonary morbidity and critical care resource utilization. This translates to an appreciable cost savings, at minimum $52,173 per patient and a potential total savings of $2.8million/year for the entire LT cohort. For tr... | yes |
25,440,352 | Is troponin-I a predictor of a delayed diagnosis of atrial fibrillation in acute ischemic stroke and transient ischemic attack? | {
"contexts": [
"Prolonged cardiac monitoring detects higher rates of atrial fibrillation (AF) in ischemic stroke and transient ischemic attack (TIA) but is costly and has practical implications. The use of admission troponin-I (TnI) level to identify patients at high risk of delayed AF detection was investigated... | TnI elevation is associated with a higher likelihood of subsequent AF diagnosis. Identification of these higher risk stroke and TIA cases for more intensive cardiac monitoring may improve stroke secondary prevention practices. | yes |
25,440,351 | Does borax partially prevent neurologic disability and oxidative stress in experimental spinal cord ischemia/reperfusion injury? | {
"contexts": [
"The aim of this study is to investigate the potential effects of borax on ischemia/reperfusion injury of the rat spinal cord.",
"Twenty-one Wistar albino rats were divided into 3 groups: sham (no ischemia/reperfusion), ischemia/reperfusion, and borax (ischemia/reperfusion + borax); each group... | Borax treatment seems to protect the spinal cord against injury in a rat ischemia/reperfusion model and improve neurological outcome. | yes |
25,433,643 | Does proteinuria predict postcardiotomy acute kidney injury in patients with preserved glomerular filtration rate? | {
"contexts": [
"Acute kidney injury is a common and serious problem after cardiac surgery. Postoperative acute kidney injury is independently associated with in-hospital mortality and long-term morbidity, even after adjustment for comorbid diseases. Chronic kidney disease has been recognized as a strong risk fac... | Urine analysis is usually neglected before cardiac surgery despite the fact that proteinuria is the earliest manifestation of kidney dysfunction. In the current study, we show that urine protein is strongly and independently associated with postoperative acute kidney injury in subjects with preserved estimated glomerul... | yes |
25,425,367 | Does ultrasound shear wave elastography help discriminate low-grade from high-grade bowel wall fibrosis in ex vivo human intestinal specimens? | {
"contexts": [
"To determine whether bowel wall fibrosis can be detected in freshly resected human intestinal specimens based on ultrasound-derived shear wave speed.",
"Seventeen intact (>3-cm) bowel segments (15 small and 2 large intestine) from 12 patients with known or suspected inflammatory bowel disease... | Ex vivo bowel wall shear wave speed measurements increase when transmural intestinal fibrosis is present. | yes |
25,443,700 | Do b-type natriuretic peptides improve cardiovascular disease risk prediction in a cohort of women? | {
"contexts": [
"Although N-terminal pro-B-type natriuretic peptide (NT-proBNP) has a strong relationship with incident cardiovascular disease (CVD), few studies have examined whether NT-proBNP adds to risk prediction algorithms, particularly in women.",
"This study sought to evaluate the relationship between... | In this multiethnic cohort of women with numerous CV events, NT-proBNP modestly improved measures of CVD risk prediction. | yes |
25,444,751 | Do novel markers predict death and organ failure following hemorrhagic shock? | {
"contexts": [
"ADAMTS 13, sP-Selectin and HSP27 have been investigated as potential prognostic markers in patients with hemorrhagic shock.",
"This study was part of a double-blind, randomized, parallel-group, controlled trial and included seventeen trauma patients presented to ED with severe hemorrhagic. Th... | Serum concentrations of ADAMTS13, HSP27 and sP-Selectin measured during the admission, appear to be comparable to or better than SBP, BD, SI, HR and StO2 in predicting MODS and death after hemorrhage from trauma. These potential new markers deserve further investigation. | yes |
25,445,404 | Is the diagnosis of inflammatory bowel disease often unsupported in clinical practice? | {
"contexts": [
"The diagnosis of inflammatory bowel disease can be challenging and requires the efforts of a multidisciplinary team. We performed a retrospective analysis with the aim of evaluating the adequacy of the prerequisites for arriving at an accurate histological diagnosis.",
"The following paramete... | Our study showed that the diagnostic prerequisites were widely unfulfilled, although approximately half of the diagnoses were conclusive for inflammatory bowel disease. Thus, in our assessment of clinical practice: (1) clinicians seldom provide suitable clinical and/or endoscopic information for a histological diagnosi... | yes |
25,445,406 | Does transjugular intrahepatic portosystemic shunt placement increase feasibility of colorectal surgery in cirrhotic patients with severe portal hypertension? | {
"contexts": [
"Colorectal resection in cirrhotic patients is associated with high mortality and morbidity related to portal hypertension and liver insufficiency.",
"This retrospective study evaluated the clinical outcomes of cirrhotic patients who underwent transjugular intrahepatic porto-systemic shunt (TI... | Portal decompression via TIPS placement may enable selected cirrhotic patients with severe portal hypertension to undergo colorectal resection for cancer. | yes |
25,424,294 | Does pentoxifylline associated to hypertonic saline solution attenuate inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats? | {
"contexts": [
"To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline.",
"It was allocated into four groups (n=6), 24 male Wistar rats (200 to 250 g) and submitted to intestinal ischemia for 40 min and reper... | The combined use of pentoxifylline and hypertonic saline offers best results on inflammatory and apoptotic inhibitory aspects after intestinal ischemia/reperfusion. | yes |
25,436,375 | Is pattern of first recurrent lesions in pancreatic cancer : hepatic relapse associated with dismal prognosis and portal vein invasion? | {
"contexts": [
"The aim of this study was to evaluate patterns of the initial recurrence after pancreatectomy for pancreatic cancer and risk factors in each pattern.",
"This study included 209 pancreatic cancer patients who underwent pancreatectomy and of whom the detailed information on the first recurrent ... | Hepatic relapse was associated with a dismal prognosis and with pathological portal vein invasion. Novel therapeutic strategies are therefore required to reduce the incidence of hepatic relapse, especially in patients with portal vein invasion. | yes |
25,425,552 | Does first registry result from the newly approved ACURATE TA™ TAVI system†? | {
"contexts": [
"The novel ACURATE TA™ transcatheter aortic valve (Symetis, Ecublens, Switzerland) is composed of a self-expanding nitinol stent covered by an anti-paravalvular leak skirt designed for transapical implantation. Since Conformite Europeenne (CE)-mark approval, the first 250 patients implanted with t... | The short-term result of the registry shows a safety and efficacy profile comparable, if not improved in some aspects, with previously approved transcatheter aortic valve implantation devices. These 'real-world' data highlight an excellent functional outcome, especially in regard to a low rate of relevant paravalvular ... | yes |
25,429,270 | Does phosphorylation of BK channels modulate the sensitivity to hydrogen sulfide ( H2S )? | {
"contexts": [
"Gases, such as nitric oxide (NO), carbon monoxide (CO), or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated. H2S is well-known to act on various ion channels and receptors. In a previous study w... | Our results suggest that phosphorylation by PKG primes the channels for H2S activation and indicate that channel phosphorylation plays an important role in the response to H2S. | yes |
25,445,772 | Is cognitive reserve a determinant of health-related quality of life in patients with cirrhosis , independent of covert hepatic encephalopathy and model for end-stage liver disease score? | {
"contexts": [
"Covert hepatic encephalopathy (CHE) is associated with cognitive dysfunction, which affects daily function and health-related quality of life (HRQOL) in patients with cirrhosis. The effects of CHE and liver disease are determined by cognitive reserve—the ability of the brain to cope with increasi... | A higher cognitive reserve is associated with a better HRQOL in patients with cirrhosis, despite similar disease severity and prevalence. This indicates that patients with good cognitive reserve are better able to withstand the demands of cirrhosis progression and CHE, leading to a better HRQOL. Patients with lower cog... | yes |
25,447,964 | Does use of PET-CT for the assessment of treatment result in patients with sarcoidosis? | {
"contexts": [
"Sarcoidosis is a multisystem disease of unknown origin. Determining the involvement and the response to the treatment is important. The aim of this study was to identify the effects of methylprednisolone and indomethacine on metabolic activity and pulmonary function test parameters in patients wi... | FDG PET-CT may be useful for determining activity and the efficacy of treatments. Methylprednisolone is effective in reducing metabolic activity but does not lead to improvement in functional parameters. | yes |
25,424,502 | Does energy replacement using glucose increase postprandial lipemia after moderate intensity exercise? | {
"contexts": [
"Aerobic exercise can decrease postprandial triglyceride (TG) concentrations but the relationship between exercise-induced energy deficits and postprandial lipemia is still unclear. The aim of the present study was to examine the effect of a single bout of aerobic exercise, with and without energy... | In conclusion, energy replacement by glucose did not affect the decrease in postprandial TG concentrations observed after moderate intensity exercise and exercise does not affect changes in PBMC HMGCR, VLDL and LDL receptor mRNA expression. | no |
25,437,889 | Is circulating retinol binding protein 4 associated with coronary lesion severity of patients with coronary artery disease? | {
"contexts": [
"This study was to examine the association between plasma retinol binding protein 4 (RBP4) levels and the complexity of angiographic coronary lesion in patients with coronary artery disease (CAD).",
"A cross-sectional and prospective study was carried out in Guangzhou Chinese population. 672 p... | Plasma RBP4 levels are significantly associated with coronary lesion complexity in women with stable CAD and ACS and predict incident cardiovascular events. | yes |
25,437,888 | Is a high quality diet associated with reduced systemic inflammation in middle-aged individuals? | {
"contexts": [
"To examine if overall diet quality is associated with cellular and soluble biomarkers of systemic inflammation in middle-aged individuals.",
"A group of 667 individuals, aged 63-68 years, selected from the cardiovascular arm of the Malmö Diet and Cancer cohort, participated in this study. Bas... | In this cross-sectional study, we found that a high diet quality is associated with lower systemic inflammation. As the incidence of cardiovascular disease and cancer is directly correlated with the levels of inflammation, our findings might indicate a protective role of high-quality diet. | yes |
25,449,169 | Does pseudoaneurysm of head and neck vessels have been frequently observed in road side bomb blast victims? | {
"contexts": [
"Due to recent war situation in neighboring country we have witnessed large number of victims with post-traumatic false (pseudo) aneurysms of head and neck in roadside bomb blast victims in Pakistan. Thus through this observational retrospective study we aim to share our experience of managing the... | Surgical intervention remains the management of choice for post-traumatic false aneurysms of head and neck in Pakistan. Despite the benefits of endovascular procedures, improvements must be weighed against the added costs on the patients. | yes |
25,435,916 | Is altered perineal microbiome associated with vulvovaginitis and urinary tract infection in preadolescent girls? | {
"contexts": [
"Vulvovaginitis has a known association with urinary tract infections (UTIs) in girls. We hypothesize that vulvovaginitis is a major contributor to UTIs in prepubertal girls by increasing periurethral colonization with uropathogens.",
"Periurethral swabs and urine specimens were obtained from ... | Vulvovaginitis may cause UTIs by altering the perineal biome such that there is increased colonization of uropathogens. | yes |
25,430,473 | Does cystamine improve functional recovery via axon remodeling and neuroprotection after stroke in mice? | {
"contexts": [
"Stroke is a leading cause of disability. However, there is no pharmacological therapy available for promoting recovery. Although treatment of stroke with cystamine has gained increasing interest, the detailed mechanisms underlying this process remain elusive. Thus, our aim is to examine the effec... | These data provide evidence to investigate the promising utility of cystamine for therapy of stroke in a variety of ways, acting principally through BDNF/TrkB pathway. | yes |
25,424,625 | Does anti-IGF-1R monoclonal antibody inhibit the carcinogenicity activity of acquired trastuzumab-resistant SKOV3? | {
"contexts": [
"Antibody resistance, not only de novo but also acquired cases, usually exists and is related with lower survival rate and high risk of recurrence. Reversing the resistance often results in better clinical therapeutic effect. Previously, we established a trastuzumab-resistant ovarian cancer cell l... | We achieved satisfactory anti-tumor activity using trastuzumab plus LMAb1 in trastuzumab-resistant ovarian cancer model. In similar cases, not only acquired but also de novo, good curative effect might be achieved using combined antibody therapy strategies. | yes |
25,424,393 | Does metabolic efficiency promote protection from pressure overload in hearts expressing slow skeletal troponin I? | {
"contexts": [
"The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I isoform,... | Expression of a single fetal myofilament protein into adulthood in the ssTnI-transgenic mouse heart induced downregulation of the gene expression response for pyruvate dehydrogenase kinase to pressure overload. The consequence of elevated pyruvate oxidation in ssTnI during TAC reduced anaplerotic flux, ameliorating ine... | yes |
25,428,515 | Does preoperative neutrophil-to-lymphocyte ratio predict response to first-line platinum-based chemotherapy and prognosis in serous ovarian cancer? | {
"contexts": [
"To investigate the role of preoperative neutrophil-to-lymphocyte ratio (NLR) in prediction of response to first-line platinum-based chemotherapy and survival outcome in serous ovarian cancer (SOC) patients.",
"Clinicopathologic data were reviewed for patients with SOC treated with primary cyt... | Our findings indicated that high levels of preoperative NLR might be a potential biomarker of worse response to first-line platinum-based chemotherapy and poor clinical outcomes in patients with SOC. Further validation of this easily available parameter as a potential stratification tool in prospective studies should b... | yes |
25,452,057 | Are alcohol mixed with energy drinks robustly associated with patterns of problematic alcohol consumption among young adult college students? | {
"contexts": [
"Young adults are a population at great risk for problematic health behaviors. Alcohol mixed with energy drink (AmED) consumption is a relatively popular health risk behavior among young adults. AmED consumption continues to illustrate negative outcomes in the research literature, having been link... | AmED consumption in the past month is robustly associated with problematic alcohol consumption. The present study describes harmful outcomes associated with AmED consumption, and extends the literature on the combined effects of alcohol and energy drinks on young adult risk behaviors. Further research needs to address ... | yes |
25,442,233 | Does home and workplace built environment support for physical activity? | {
"contexts": [
"Physical inactivity has been associated with obesity and related chronic diseases. Understanding built environment (BE) influences on specific domains of physical activity (PA) around homes and workplaces is important for public health interventions to increase population PA.",
"To examine th... | This study offers empirical evidence on BE supports for domain-specific PA. Findings suggest that diverse, attractive, and walkable neighborhoods around workplaces support walking, bicycling, and use of public transit. Public health practitioners, researchers, and worksite leaders could benefit by utilizing worksite do... | yes |
25,424,888 | Do young low-income ethnic minority children watch less television when their mothers regulate what they are viewing? | {
"contexts": [
"Parenting practices can reduce how much television (TV) children watch. This study evaluated the longitudinal association between maternal regulation of TV content and the amount of TV watched by low-income ethnic minority children.",
"This was a secondary data analysis of the Welfare, Childr... | Our findings suggest that regulating content influences viewing amounts in young children approximately 16 months later. Interventions focused on heightening parental regulation of content may improve content and diminish viewing amounts. | yes |
25,439,802 | Is clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos low? | {
"contexts": [
"To determine the clinically recognizable error rate with the use of quantitative polymerase chain reaction (qPCR)-based comprehensive chromosomal screening (CCS).",
"Retrospective study.",
"Multiple fertility centers.",
"All patients receiving euploid designated embryos.",
"Trophe... | The clinically recognizable error rate with qPCR-based CCS is real but quite low. Although evaluated in only a limited number of specimens, mosaicism appears to play a prominent role in misdiagnoses. Mosaic errors present a genuine limit to the effectiveness of aneuploidy screening, because they are not attributable to... | yes |
25,450,249 | Do human adenovirus Ad36 and its E4orf1 gene enhance cellular glucose uptake even in the presence of inflammatory cytokines? | {
"contexts": [
"Aging and obesity are associated with elevated pro-inflammatory cytokines such as monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)α, which are linked to insulin resistance. Anti-inflammatory agents have marginal effect in improving insulin resistance. Hence, agents are nee... | Unlike Ad36, E4orf1 does not appear to stimulate inflammatory response. Ad36 and E4orf1 both enhance cellular glucose uptake even in presence of inflammation. Further research is needed to harness this novel and beneficial property of E4orf1 to improve hyperglycemia despite chronic inflammation that is commonly present... | yes |
25,429,575 | Does femoral insufficiency fractures in the elderly - excessive medial femoral bowing complicate intramedullary nailing? | {
"contexts": [
"The aim of this study was to evaluate the characteristics of low-energy femoral insufficiency fractures in elderly patients.",
"The study retrospectively evaluated the clinical course of 4 patients with low-energy femoral shaft and subtrochanteric fractures admitted to our department between ... | We suggest the addition of another radiographic pattern of 'excessive medial femoral bowing' in low-energy femoral shaft fractures in elderly patients. This bowing complicates intramedullary nailing. Moreover, these insufficiency fractures should be fixed with long cephalomedullary nails. | yes |
25,432,266 | Do mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum? | {
"contexts": [
"Mutation of Arabidopsis DMR1, encoding homoserine kinase, leads to elevation in homoserine and foliar resistance to the biotrophic pathogens Hyaloperonospora arabidopsidis and Oidium neolycopersici through activation of an unidentified defence mechanism. This study investigates the effect of muta... | These findings suggest that common Arabidopsis DMR1 mediated susceptibility mechanisms occur during infection by both obligate biotrophic oomycete and hemi-biotrophic fungal pathogens, not only in vegetative but also in reproductive plant tissues. This has the potential to aid the development of cereal crops with enhan... | yes |
25,427,743 | Does ultrasound elastography correlate treatment response by antiviral therapy in patients with chronic hepatitis C? | {
"contexts": [
"To investigate the relationship between tissue elasticity before and after antiviral therapy and shear wave as well as strain elastography.",
"FibroScan and real-time tissue elastography were performed before and after antiviral therapy for chronic hepatitis C, and treatment efficacy and elas... | With a few exceptions, SVR improved LS. All patients with an increase in LFI were in the non-SVR group, even though LFI decreased in 2 patients. Our findings suggest that an LFI increase indicates lack of treatment efficacy with antiviral therapy. LFI may be useful for the assessment of treatment efficacy in patients w... | yes |
25,445,726 | Does very urgent carotid endarterectomy increase the procedural risk? | {
"contexts": [
"The timing of CEA for symptomatic internal carotid artery (ICA) stenosis remains a matter of controversy. Recent registry data showed a significantly increased risk, especially in the very early days after the onset of symptoms. In this study the outcome of CEA in the hyperacute phase has been in... | These data show that very urgent surgery in symptomatic patients can be performed without increased procedural risk. Given the fact that ruptured plaques with neurological symptoms carry the highest risk of a recurrent ischemic event in the first 2 days, treating patients as soon as possible to offer the highest benefi... | no |
25,446,402 | Does b7-H4 overexpression impair the immune response of T cells in human cervical carcinomas? | {
"contexts": [
"To investigate B7-H4 expression and its correlation with the number of infiltrating T lymphocytes and cytokine production by those lymphocytes in human cervical cancer and to determine the effect of recombinant B7-H4 on the active peripheral blood T cells of the patients in vitro.",
"B7-H4 ex... | B7-H4 is overexpressed in human cervical cancers, and it is associated with lower numbers of tumor-infiltrating CD8(+)T lymphocytes and therefore less IFN-γ production. In vitro, B7-H4 inhibits the proliferation of CD4(+)T and CD8(+)T but promotes the proliferation of Tregs and the secretion of IL-10 and TGF-β1. B7-H4 ... | yes |
25,432,525 | Does preoperative mp-MRI of the prostate provide little information about staging of prostate carcinoma in daily clinical practice? | {
"contexts": [
"To evaluate the staging accuracy of preoperative multiparametric MRI (mp-MRI), its influence on the technique of radical retropubic prostatectomy (RRP), and its value for daily clinical practice.",
"A total of 106 patients underwent RRP (January 2011-June 2012) and had preoperative MRI stagin... | In routine clinical practice, mp-MRI at non-academic centers has very limited clinical value in predicting ECE and SVI. Our data support the current recommendations against the widespread preoperative use of mp-MRI because it is not adding reliable predictive information on the extent of prostate cancer. | yes |
25,432,521 | Do gene expression and genetic analysis reveal diverse causes of recessive self-compatibility in Brassica napus L? | {
"contexts": [
"Brassica napus (AACC) is self-compatible, although its ancestor species Brassica rapa (AA) and Brassica oleracea (CC) are self-incompatible. Most B.napus accessions have dominant self-compatibility (SC) resulting from an insertion of 3.6 kb in the promoter region of BnSCR-1 on the A genome, while... | The recessive SC in eight accessions is caused by the loss of function of BnSCR-7 and BnSCR-6 in pollen. Translational repression contributes to the recessive SC in three accessions, whose SRK and SCR genes were expressed normally and had identical CDSs to BrS-29 or BoS-15. SI in 11 F1 hybrids relies on the expression ... | yes |
25,441,644 | Do prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk? | {
"contexts": [
"Prostaglandin D2 (PGD2) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate TH2 cells. The combination of PGD2 and cysLTs (notably cysteinyl leukotriene E4 [LTE4]) enhances TH2 cytokine production. However, the synergistic interaction of cysLTs with PGD... | PGD2 and LTE4 activate TH2 cells through different pathways but act synergistically to promote multiple downstream effector functions, including neutrophil migration and survival. Combined inhibition of both PGD2 and LTE4 pathways might provide an effective therapeutic strategy for allergic responses, particularly thos... | yes |
25,441,645 | Does consumption of unprocessed cow 's milk protect infants from common respiratory infections? | {
"contexts": [
"Breast-feeding is protective against respiratory infections in early life. Given the co-evolutionary adaptations of humans and cattle, bovine milk might exert similar anti-infective effects in human infants.",
"To study effects of consumption of raw and processed cow's milk on common infectio... | Early life consumption of raw cow's milk reduced the risk of manifest respiratory infections and fever by about 30%. If the health hazards of raw milk could be overcome, the public health impact of minimally processed but pathogen-free milk might be enormous, given the high prevalence of respiratory infections in the f... | yes |
25,425,158 | Does melatonin-sulforaphane hybrid ITH12674 induce neuroprotection in oxidative stress conditions by a 'drug-prodrug ' mechanism of action? | {
"contexts": [
"Neurodegenerative diseases are a major problem afflicting ageing populations; however, there are no effective treatments to stop their progression. Oxidative stress and neuroinflammation are common factors in their pathogenesis. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the master reg... | ITH12674 combines the signalling pathways of the parent compounds to improve its neuroprotective properties. This opens a new line of research for such hybrid compounds to treat neurodegenerative diseases. | yes |
25,445,244 | Does comprehensive analysis suggest simple processes underlying EEG/ERP - demonstration with the go/no-go paradigm in ADHD? | {
"contexts": [
"Current basic or more advanced methods for analysis of averaged EEG/ERP are based on assumptions on the underlying processes, which are not necessarily precise.",
"In this work we present the findings of a method which obviates such assumptions and aims at a comprehensive analysis of the aver... | We show how these processes accord with and provide insight on the waveforms reported in the literature. | yes |
25,432,921 | Does endometriosis also affect the decidua in contact with the fetal membranes during pregnancy? | {
"contexts": [
"Are the fetal membranes of women affected with endometriosis similar to those from disease-free women?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Case-Control Studies",
"Cesarean Section",
"Cohort Studies",
"CpG Islands",
"DNA Methylation",
"Decid... | Decidua of women with endometriosis is able to generate endometriotic-like lesions in contact with the fetal membranes. | yes |
25,432,923 | Do endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation? | {
"contexts": [
"Do endometriotic ovarian cysts influence the rate of spontaneous ovulation?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Endometriosis",
"Endometrium",
"Female",
"Follow-Up Studies",
"Humans",
"Infertility, Female",
"Italy",
"Lost to Follow-... | Endometriotic cysts, no matter what their volume, do not influence the rate of spontaneous ovulation in the affected ovary. | no |
25,426,158 | Do song characteristics track bill morphology along a gradient of urbanization in house finches ( Haemorhous mexicanus )? | {
"contexts": [
"Urbanization can considerably impact animal ecology, evolution, and behavior. Among the new conditions that animals experience in cities is anthropogenic noise, which can limit the sound space available for animals to communicate using acoustic signals. Some urban bird species increase their song... | These findings are consistent with the hypothesis that birds with longer beaks and therefore longer vocal tracts sing songs with lower maximum frequencies because longer tubes have lower-frequency resonances. Thus, for the first time, we reveal dual constraints (one biotic, one abiotic) on the song frequency range of u... | yes |
25,443,731 | Do the effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice? | {
"contexts": [
"According to reports in the literature, more than 30% of depressive patients fail to achieve remission. Therapy with the conventional antidepressant drugs may induce the serious adverse reactions. Moreover, its benefits may be seen at least 2-4 weeks after the first dose. Therefore, the alternati... | The concomitant administration of certain commonly prescribed antidepressant drugs that affect the serotonergic neurotransmission (i.e., typical tricyclic antidepressants and selective serotonin reuptake inhibitors) with a negative modulator selectively binding to the GluN1/N2B subunits of the NMDA receptor complex (i.... | yes |
25,433,952 | Does pulmonary morbidity improve after autologous stem cell transplantation in POEMS syndrome? | {
"contexts": [
"POEMS syndrome is a plasma cell disorder manifested by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. Pulmonary morbidity includes restriction, decreased diffusing capacity for carbon monoxide (DLCO), respiratory muscle weakness, abnormal imaging, and pulmon... | Patients with POEMS syndrome treated with aPBSCT have significant improvement in PFTs, respiratory muscle strength, imaging, and post-transplant IL-6. The improvement in PFTs persists during long-term follow-up. | yes |
25,423,567 | Do nitric oxide and cGMP induce COX-2 expression and PGE2 production in human granulosa cells through CREB signaling pathway? | {
"contexts": [
"It is well known that cyclooxygenase-2 (COX-2) and its major derivative product prostaglandin E2 (PGE2) play key regulatory roles in the ovulation process. Animal studies have demonstrated that the inhibition of nitric oxide (NO) suppresses ovarian PGE2 production and ovulation. Although the expr... | CREB mediates NO and cGMP-induced COX-2 expression and PGE2 production, which subsequently contribute to NO-regulated ovulation in human granulosa cells. | yes |
25,423,566 | Does miR-219-5p modulate cell growth of papillary thyroid carcinoma by targeting estrogen receptor α? | {
"contexts": [
"Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It has been demonstrated that micro-RNAs (miRNAs) are involved in the development of PTC. The miRNA-chromatin immunoprecipitation microarray assay revealed down-regulation of miR-219-5p; however, the effect of miR-219-5p o... | Our investigation identified miR-219-5p as a negative regulator of PTC development through targeting of ERα. | yes |
25,423,565 | Is hypothalamic damage associated with inflammatory markers and worse cognitive performance in obese subjects? | {
"contexts": [
"Growing evidence implicates hypothalamic inflammation in the pathogenesis of diet-induced obesity and cognitive dysfunction in rodent models. Few studies have addressed the association between obesity and hypothalamic damage in humans and its relevance.",
"This study aimed to determine marker... | DTI detects obesity-associated hypothalamic damage associated with inflammatory markers and worse cognitive performance. This study highlights the potential utility of λ(1) as a surrogate marker of obesity-associated hypothalamic damage. | yes |
25,423,568 | Is s100A8 a novel therapeutic target for anaplastic thyroid carcinoma? | {
"contexts": [
"Anaplastic thyroid carcinoma (ATC) is one of the most deadly human malignancies. It is 99% lethal, and patients have a median survival of only 6 months after diagnosis. Despite these grim statistics, the mechanism underlying the tumorigenic capability of ATC cells is unclear.",
"S100A8 and S1... | These findings establish a novel role for S100A8 in the promoting and enhancing of ATC progression. They further suggest that the inhibition of S100A8 could represent a relevant therapeutic target, with the potential of enabling a more effective treatment path for this deadly disease. | yes |
25,429,009 | Do associations of Heart Rate With Inflammatory Markers Are Modulated by Gender and Obesity in Older Adults? | {
"contexts": [
"Faster resting heart rate (HR), which is associated with inflammation and elevated cortisol levels, is a risk factor for excess cardiovascular morbidity and mortality. Obesity is associated with increased cardiovascular morbidity and mortality, inflammation, and elevated cortisol levels. The aim ... | Faster HR is associated with proinflammatory state in elderly patients; this association seems to be limited to women with higher BMI. | yes |
25,429,007 | Do plant traits respond to the competitive neighbourhood at different spatial and temporal scales? | {
"contexts": [
"Clonal plants can plastically modify their traits in response to competition, but little is known regarding the spatio-temporal scale at which a competitive neighbourhood determines the variability in species traits. This study tests the hypothesis that the local neighbourhood can be expected to ... | This study demonstrates that the traits of a single clonal individual can respond to different competitive environments in space and time. The results thus contribute to the understanding of competition mechanisms. | yes |
25,440,680 | Are endoscopy and EUS key for effective surveillance and management of duodenal adenomas in familial adenomatous polyposis? | {
"contexts": [
"Patients with familial adenomatous polyposis (FAP) are prone to developing duodenal adenoma and cancer. Optimal surveillance and management of these adenomas are not well established.",
"We assessed the outcome of FAP patients undergoing intense multimodal surveillance and subsequent endoscop... | Limited follow-up period, young age group, uncontrolled study. | yes |
25,426,619 | Are well differentiation and intact Smad4 expression specific features of groove pancreatic ductal adenocarcinomas? | {
"contexts": [
"We aimed to select true groove pancreatic ductal adenocarcinomas (GPDACs) and define their specific features.",
"We performed histopathologic and immunohistochemical comparisons of 6 GPDACs with 6 duodenal adenocarcinomas (DACs) and 24 conventional pancreatic ductal adenocarcinomas (cPDACs). ... | These results suggest that GPDACs arise from small branch pancreatic ducts around accessory pancreatic duct penetrating the groove and duodenum and are distinguishable from DACs. Molecular immunohistochemistry suggests the accumulation of genetic abnormalities during tumor progression is slow in comparison with cPDACs.... | yes |
25,426,613 | Does peroxiredoxin 1 promote pancreatic cancer cell invasion by modulating p38 MAPK activity? | {
"contexts": [
"The aim of this study was to investigate the role of peroxiredoxin 1 (Prdx1) in the invasiveness of pancreatic ductal adenocarcinoma (PDAC) cells.",
"Immunohistochemistry was used to determine overexpression of Prdx1 in human PDAC tissues. Immunoprecipitation and immunocytochemistry were used... | Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p38 MAPK, which in turn promotes PDAC cell invasion. | yes |
25,426,616 | Do increased interleukin-23/17 axis and C-reactive protein are associated with severity of acute pancreatitis in patients? | {
"contexts": [
"The interleukin (IL)-23/IL-17 axis plays an important role in various inflammatory conditions but its function in acute pancreatitis (AP) is not well understood. The present study investigated the relationship between serum levels of IL-23, IL-17, and C-reactive protein (CRP) in patients and the ... | The serum levels of IL-17, IL-23, and CRP are correlated with the severity of AP and represent valuable prognostic factors in the assessment of disease severity of patients with AP. | yes |
25,427,013 | Does [ Waist-to-height ratio change with gender , age and pubertal stage in elementary school children ]? | {
"contexts": [
"Waist-to-height ratio (WHtR) is a cardiometabolic risk indicator in children. A value greater than or equal to 0.55 is an effective screening tool for identifying obese children with metabolic syndrome. However, it is unclear whether this cutoff can be applied equally to any age or gender.",
... | Since WHtR does not vary with age, gender and pubertal status in elementary school children, it is possible to use a single cutoff value, previously defined in this population, to identify children with cardiometabolic risk. | no |
25,448,612 | Do maternal and childhood psychological factors predict chronic disabling fatigue at age 13 years? | {
"contexts": [
"To investigate whether premorbid maternal and childhood psychological problems are risk factors for chronic disabling fatigue at age 13 years among children in the Avon Longitudinal Study of Parents and Children birth cohort.",
"Chronic disabling fatigue was defined as fatigue of at least 3-m... | Pediatricians need to be aware that children whose mothers experience anxiety and/or depression between pregnancy and child's age 6 years have an increased risk of developing chronic disabling fatigue in early adolescence. Conversely, clinicians need to be alert to fatigue in children whose mothers have longstanding an... | yes |
25,449,565 | Is position-related injury uncommon in robotic gynecologic surgery? | {
"contexts": [
"To assess the rate and risk factors for position-related injury in robotic gynecologic surgery.",
"A prospective database from 12/2006 to 1/2014 of all planned robotic gynecologic procedures was retrospectively reviewed for patients who experienced neurologic injury, musculoskeletal injury, o... | The incidence of position-related injury among women undergoing robotic surgery was extremely low (0.8%). Due to the low incidence we were unable to identify modifiable risk factors for position-related injury following robotic surgery. A standardized, team-oriented approach may significantly decrease position-related ... | yes |
25,451,237 | Is increased alcohol consumption in urocortin 3 knockout mice unaffected by chronic inflammatory pain? | {
"contexts": [
"Stress neurocircuitry may modulate the relationship between alcohol drinking and chronic pain. The corticotropin-releasing factor (CRF) system is crucial for regulation of stress responses. The current study aimed to elucidate the role of the endogenous CRF ligand Urocortin 3 (Ucn3) in the relati... | The increased drinking in Ucn3 KO supports a role for this peptide in alcohol-related behavior. These data suggest the necessity for more research exploring the relationship between alcohol drinking, chronic pain and the CRF system in rodent models. | yes |
25,441,109 | Does serum free light chain response after 2 courses of induction chemotherapy predict prognosis in myeloma patients? | {
"contexts": [
"The aim of this study was to investigate the prognostic effect of serum free light chain (sFLC) response after 2 cycles of first-line chemotherapy (CT) in multiple myeloma (MM) patients.",
"The data of 78 newly diagnosed MM patients who had sFLC levels at diagnosis and after 2 cycles of first... | Early response assessment in terms of sFLC after 2 courses of induction CT seems to have a prognostic effect in MM patients. The methodology and timing of the evaluation based on sFLCs needs to be validated in prospective studies. | yes |
25,435,628 | Does protopine inhibit heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors? | {
"contexts": [
"A Chinese herb Corydalis yanhusuo W.T. Wang that showed anticancer and anti-angiogenesis effects in our previous studies was presented for further studies. In the present study, we studied the anticancer proliferation and adhesion effects of five alkaloids which were isolated from Corydalis yanhu... | The present results suggest that protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors. | yes |
25,446,250 | Does hydrogen sulfide protect testicular germ cells against heat-induced injury? | {
"contexts": [
"The present study was designed to investigate whether H2S can protect testicular germ cells against heat exposure induced injury and the underlying mechanisms.",
"It was found that all three H2S generating enzymes, cystathionine β-synthase (CBS), cystathionine γ-lysase (CSE), and 3-mercaptopy... | Our results revealed both physiological and pharmacological roles of H2S in testicular germ cells. Exogenous application of H2S may protect germ cells by preservation of mitochondrial function and stimulation of anti-oxidant activity. | yes |
25,445,501 | Is long noncoding RNA PCA3 gene promoter region related to the risk of prostate cancer on Chinese males? | {
"contexts": [
"Long noncoding RNA prostate cancer gene antigen 3 (PCA3) is one of the most prostate cancer-specific genes at present. Consequently, the prostate-specific expression and the sharp up-regulation of PCA3 RNA in prostate cancer suggest a unique transcriptional regulation, which possibly can be attri... | The results of this study suggest that short tandem repeat polymorphism of TAAA in the promoter region of PCA3 gene is a risk-increasing factor for prostate cancer in the Chinese population. In addition to the hereditary factor, the insertion mutation of (TAAA)n in a local tissue maybe another mechanism of the onset of... | yes |
25,445,500 | Does ski diminish TGF-β1-induced myofibroblast phenotype via up-regulating Meox2 expression? | {
"contexts": [
"The aim of the present work was to investigate the mechanism of transforming growth factor (TGF)-β1 and Sloan-Kettering Institute (Ski) in the pathogenesis of hypertrophic scars (HS).",
"Wound healing is an inherent process, but the aberrant wound healing of skin injury may lead to HS. There ... | Ski diminishes the myofibroblast phenotype induced by TGF-β1 through the suppression of Zeb2 by up-regulating the expression of Meox2. | yes |
25,445,227 | Does docosahexaenoic acid induce M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation? | {
"contexts": [
"Impaired resolution of acute inflammation results in development of chronic inflammatory disorders such as atherosclerosis, asthma and arthritis. Clearance of apoptotic neutrophils by M2 macrophages, the process termed efferocytosis, is critical for complete resolution of inflammation as it preve... | These findings indicate that DHA can promote resolution of inflammation by facilitating efferocytosis through M2 macrophage polarization. Therefore, DHA may have a therapeutic potential in the management of inflammatory diseases which are related to impaired resolution of inflammation. | yes |
25,432,701 | Does different approaches for interpretation and reporting of immunohistochemistry analysis result in the bone tissue - a review? | {
"contexts": [
"Immunohistochemistry (IHC) is a well-established, widely accepted method in both clinical and experimental parts of medical science. It allows receiving valuable information about any process in any tissue, and especially in bone. Each year the amount of data, received by IHC, grows in geometric ... | The overview of the existing approaches in evaluation and interpretation of IHC data, which are provided in the article, can be used in bone tissue research and for either better understanding of existing scoring systems or developing a new one. Standard multiparametric, semiquantitative IHC scoring systems should simp... | yes |
25,439,617 | Do survey of radiologist attitudes and perceptions regarding the incorporation of a departmental peer review system? | {
"contexts": [
"The aim of this study was to investigate the attitudes and perceptions of staff radiologists regarding the incorporation of a nonanonymous peer review system at an academic hospital.",
"A questionnaire gauging knowledge of, attitudes toward, and perceptions regarding peer review was distribut... | The incorporation of a nonanonymous peer review system generates anxiety and uncertainty within a radiology department. The investigation of physicians' attitudes toward and perceptions about peer review is important for understanding the potential impact not only on patient care but also on radiologists' relationships... | yes |
25,449,356 | Does naringin ameliorate memory deficits in experimental paradigm of Alzheimer 's disease by attenuating mitochondrial dysfunction? | {
"contexts": [
"Mitochondrial dysfunction has been well documented in age related disorders like Alzheimer's disease. Alterations in mitochondrial membrane potential lead to neuronal death by excessive generation of free radicals, inflammatory cytokines, and excitotoxins. Intracerebroventricular (ICV) streptozot... | Our findings demonstrate that naringin ameliorates mitochondrial dysfunction mediated oxido-nitrosative stress and inflammatory surge in ICV-STZ rats. | yes |
25,449,357 | Does tanshinone IIA attenuate neuropathic pain via inhibiting glial activation and immune response? | {
"contexts": [
"Neuropathic pain, characterized by spontaneous pain, hyperalgesia and allodynia, is a devastating neurological disease that seriously affects patients' quality of life. We have previously shown that tanshinone IIA (TIIA), an important lipophilic component of Danshen, had significant anti-nocicept... | Taken together, our study provides evidence that TIIA inhibited SNL-induced neuropathic pain through depressing microglial activation and immune response by the inhibition of mitogen-activated protein kinases (MAPKs) pathways. Our findings suggest that TIIA might be a promising agent in the treatment of neuropathic pai... | yes |
25,449,350 | Are microcirculatory perfusion and vascular reactivity altered in post cardiac arrest patients , irrespective of target temperature management to 33 °C vs 36 °C? | {
"contexts": [
"In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arres... | In this relatively small sample size study microcirculatory blood flow and vascular reactivity did not differ nor change between TTM33 and TTM36. | yes |
25,426,763 | Does gRIN2B mediate susceptibility to intelligence quotient and cognitive impairments in developmental dyslexia? | {
"contexts": [
"Developmental dyslexia (DD) is a complex heritable condition associated with impairments in multiple neurocognitive domains. Substantial heritability has been reported for DD and related phenotypes, and candidate genes have been identified. Recently, a candidate gene for human cognitive processes... | Our results add further evidence in support of GRIN2B contributing toward DD and deficits in DD. More specifically, our data support the view that GRIN2B influences DD as a categorical trait and its related quantitative phenotypes, thus shedding further light on the etiologic basis and the phenotypic complexity of this... | yes |
25,430,407 | Are arterial stiffness and central arterial wave reflection associated with serum uric acid , total bilirubin , and neutrophil-to-lymphocyte ratio in patients with coronary artery disease? | {
"contexts": [
"Total bilirubin (TB) was recently recognized as an endogenous anti-inflammatory and anti-oxidant molecule. Uric acid (UA) takes part in cardiovascular diseases by inducing oxidative stress, inflammation, and endothelial dysfunction. We assessed the relationship between serum TB levels, serum UA l... | N/L ratio and serum UA and TB levels might be used to risk-stratify patients with respect to arterial stiffness in CAD patients, especially in the presence of ACS. | yes |
25,438,111 | Is minimally invasive coronary artery bypass grafting associated with improved clinical outcomes? | {
"contexts": [
"Minimally invasive coronary artery bypass grafting (MICS CABG) via left minithoracotomy is an alternative to off-pump coronary artery bypass (OPCAB) via sternotomy. Our objective was to evaluate the clinical outcomes after MICS CABG versus OPCAB.",
"The medical records of patients who underwe... | Minimally invasive coronary artery bypass grafting is safe, and early clinical outcomes are comparable, if not superior in some respects, to OPCAB. Extubation in the OR is feasible, well tolerated, and associated with earlier discharge. Shorter hospital stays may decrease resource use and promote earlier return to acti... | yes |
25,443,718 | Is antiproliferative effect induced by novel imidazoline S43126 in PC12 cells mediated by ROS , stress activated MAPKs and caspases? | {
"contexts": [
"Some imidazoline compounds have pleiotropic effects including cell death in vitro. We examined the antiproliferative action of a novel imidazoline compound S43126, and the role of the I1-imidazoline receptor, ROS, MAPKs and caspases in S43126-induced cell death.",
"PC 12 cells were treated wi... | Our data showed that the effects of S43126 on PC12 cell death were partly mediated by ROS production, MAPK and caspase activation. These results further indicate an emerging role for I1R in apoptotic processes. | yes |
25,443,719 | Does chronic administration of phenytoin induce efflux transporter overexpression in rats? | {
"contexts": [
"Efflux transporters overexpression has been proposed as one of the responsible mechanism for refractory epilepsy by preventing access of the antiepileptic drug to the brain. In this work we investigated whether phenytoin (PHT), could induce efflux transporters overexpression, at different biologi... | Overexpression of efflux transporters can be mediated by inducer agents like PHT in a local-concentration dependent manner, and it is reversible once the substance is removed from the body. The recovery of basal Pgp expression could allow the design of dosing schedules that optimize anticonvulsant therapy. | yes |
25,444,747 | Is negative feedback loop of cholesterol regulation impaired in the livers of patients with Alagille syndrome? | {
"contexts": [
"To characterize cholesterol regulation in the liver of patients with Alagille syndrome (AGS).",
"Serum total cholesterol (TC) and total bile acid (TBA) levels were measured in 23 AGS patients. The expressions of genes involved in cholesterol regulation, including low-density lipoprotein recep... | The major upregulators of liver cholesterol might be increased in AGS patients, indicating an impaired negative feedback mechanism and accelerated liver cholesterol accumulation. | yes |
25,444,749 | Is sULF2 , a heparan sulfate endosulfatase , present in the blood of healthy individuals and increases in cirrhosis? | {
"contexts": [
"SULF2 is an extracellular sulfatase that acts on heparan sulfate proteoglycans and modulates multiple signaling pathways. It is normally bound to the cell surface but can be released into the medium of cultured cells. SULF2 is known to be increased in cirrhotic liver compared to healthy liver. We... | SULF2 may be a useful serologic biomarker for liver cirrhosis. | yes |
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