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Entry_x
string
Sequence
string
length
int64
mol_weight
float64
iso_point
float64
aromaticity
float64
instability_index
float64
gravy
float64
helix_frac
float64
turn_frac
float64
sheet_frac
float64
count_A
int64
percent_A
float64
count_C
int64
percent_C
float64
count_D
int64
percent_D
float64
count_E
int64
percent_E
float64
count_F
int64
percent_F
float64
count_G
int64
percent_G
float64
count_H
int64
percent_H
float64
count_I
int64
percent_I
float64
count_K
int64
percent_K
float64
count_L
int64
percent_L
float64
count_M
int64
percent_M
float64
count_N
int64
percent_N
float64
count_P
int64
percent_P
float64
count_Q
int64
percent_Q
float64
count_R
int64
percent_R
float64
count_S
int64
percent_S
float64
count_T
int64
percent_T
float64
count_V
int64
percent_V
float64
count_W
int64
percent_W
float64
count_Y
int64
percent_Y
float64
charge_pH7
int64
boman_index
float64
aliphatic_index
float64
hydrophobic_moment
float64
Entry_y
string
Entry Name
string
Protein names
string
Organism
string
Length
int64
Mass
int64
Subcellular location [CC]
string
Gene Ontology (biological process)
string
Gene Ontology (molecular function)
string
EC number
string
Disruption phenotype
string
Catalytic activity
string
Pathway
string
Subcellular location [CC].1
string
Function [CC]
string
Domain [CC]
string
Induction
string
Disruption phenotype.1
string
P55036
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPA...
377
40,736.2143
4.682248
0.034483
45.759151
-0.457029
0.381963
0.30504
0.291777
38
0.101
4
0.011
28
0.074
35
0.093
10
0.027
27
0.072
6
0.016
16
0.042
24
0.064
34
0.09
13
0.034
18
0.048
16
0.042
17
0.045
15
0.04
26
0.069
24
0.064
23
0.061
0
0
3
0.008
377
40,735.36
-23.369
-0.000574
P55036
PSMD4_HUMAN
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Homo sapiens (Human)
377
40,737
nan
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]
identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]
nan
nan
nan
nan
nan
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose ...
DOMAIN: The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way. {ECO:0000269|PubMed:15826667, ECO:0000269|PubMed:19683493}.
nan
nan
P54920
MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
295
33,232.3678
5.228699
0.098305
47.337966
-0.347458
0.444068
0.216949
0.301695
41
0.139
8
0.027
17
0.058
28
0.095
13
0.044
11
0.037
7
0.024
17
0.058
26
0.088
26
0.088
10
0.034
12
0.041
3
0.01
14
0.047
8
0.027
21
0.071
9
0.031
8
0.027
2
0.007
14
0.047
295
33,231.49
-10.972
-0.00033
P54920
SNAA_HUMAN
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Homo sapiens (Human)
295
33,233
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [...
protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.
nan
nan
nan
P55263
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFV...
362
40,544.9599
6.236909
0.088398
39.473508
-0.317956
0.378453
0.234807
0.337017
39
0.108
7
0.019
21
0.058
29
0.08
21
0.058
19
0.052
10
0.028
25
0.069
34
0.094
27
0.075
8
0.022
15
0.041
14
0.039
16
0.044
12
0.033
16
0.044
19
0.052
19
0.052
2
0.006
9
0.025
362
40,544.11
-3.686
-0.000091
P55263
ADK_HUMAN
Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase)
Homo sapiens (Human)
362
40,545
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}.
AMP salvage [GO:0044209]; dAMP salvage [GO:0106383]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166]; ribonucleoside monophosphate biosynthetic process [GO:0009156]
adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]
2.7.1.20
nan
CATALYTIC ACTIVITY: Reaction=adenosine + ATP = AMP + ADP + H(+); Xref=Rhea:RHEA:20824, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20; Evidence={ECO:0000269|PubMed:21963049, ECO:0000269|PubMed:8577746, ECO:0000269|PubMed:9070863}; PhysiologicalDirection=left...
PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}.
FUNCTION: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. {ECO:0000269|PubMed:21963049, ECO:0000269|PubMed:8577746, ECO:0000269|PubMed:90708...
nan
nan
nan
P54855
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEE...
530
61,035.6172
8.976916
0.128302
33.589075
-0.043208
0.341509
0.258491
0.407547
29
0.055
9
0.017
23
0.043
27
0.051
33
0.062
27
0.051
15
0.028
32
0.06
44
0.083
60
0.113
21
0.04
23
0.043
23
0.043
15
0.028
17
0.032
41
0.077
23
0.043
33
0.062
14
0.026
21
0.04
530
61,034.84
11.186
0.000183
P54855
UDB15_HUMAN
UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
Homo sapiens (Human)
530
61,036
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]
glucuronosyltransferase activity [GO:0015020]
2.4.1.17
nan
CATALYTIC ACTIVITY: Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+); Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18719240...
nan
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:2328886...
nan
nan
nan
P54840
MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDL...
703
80,988.1014
6.348483
0.113798
43.977838
-0.39431
0.291607
0.268848
0.378378
40
0.057
11
0.016
43
0.061
49
0.07
40
0.057
41
0.058
28
0.04
36
0.051
37
0.053
64
0.091
15
0.021
27
0.038
34
0.048
22
0.031
46
0.065
44
0.063
40
0.057
46
0.065
12
0.017
28
0.04
703
80,987.36
-8.573
-0.000106
P54840
GYS2_HUMAN
Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)
Homo sapiens (Human)
703
80,989
nan
glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749]
alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]
2.4.1.11
nan
CATALYTIC ACTIVITY: Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + UDP + H(+); Xref=Rhea:RHEA:18549, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11; Evidence={ECO:0000269|PubMed:1731614, EC...
PATHWAY: Glycan biosynthesis; glycogen biosynthesis. {ECO:0000269|PubMed:1731614, ECO:0000269|PubMed:9691087}.
nan
FUNCTION: Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to ...
nan
nan
nan
P54802
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPP...
743
82,264.661
6.19985
0.121131
40.981575
-0.038627
0.332436
0.271871
0.370121
95
0.128
8
0.011
27
0.036
40
0.054
34
0.046
60
0.081
14
0.019
17
0.023
12
0.016
87
0.117
13
0.017
23
0.031
44
0.059
35
0.047
49
0.066
48
0.065
29
0.039
52
0.07
26
0.035
30
0.04
743
82,263.92
-5.696
-0.000069
P54802
ANAG_HUMAN
Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]
Homo sapiens (Human)
743
82,266
SUBCELLULAR LOCATION: Lysosome.
adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to oxidative ...
alpha-N-acetylglucosaminidase activity [GO:0004561]
3.2.1.50
nan
CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.; EC=3.2.1.50;
nan
SUBCELLULAR LOCATION: Lysosome.
FUNCTION: Involved in the degradation of heparan sulfate.
nan
nan
nan
P54821
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
245
27,296.0834
9.48151
0.061224
54.882449
-0.790204
0.326531
0.318367
0.281633
26
0.106
1
0.004
12
0.049
15
0.061
6
0.024
12
0.049
3
0.012
3
0.012
11
0.045
23
0.094
5
0.02
19
0.078
13
0.053
15
0.061
22
0.09
22
0.09
14
0.057
14
0.057
2
0.008
7
0.029
245
27,295.18
6.952
0.000255
P54821
PRRX1_HUMAN
Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)
Homo sapiens (Human)
245
27,296
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63013}.
artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; mesenchymal cell proliferation [GO:0010463]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO...
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-reg...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63013}.
FUNCTION: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (...
nan
nan
nan
P54710
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP
66
7,283.2441
7.8845
0.106061
67.080455
-0.292424
0.257576
0.378788
0.348485
2
0.03
1
0.015
5
0.076
3
0.045
4
0.061
11
0.167
0
0
4
0.061
3
0.045
7
0.106
2
0.03
3
0.045
3
0.045
1
0.015
6
0.091
3
0.045
2
0.03
3
0.045
0
0
3
0.045
66
7,282.29
1.831
0.000251
P54710
ATNG_HUMAN
Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain)
Homo sapiens (Human)
66
7,283
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
cellular hyperosmotic salinity response [GO:0071475]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; negative regulation of cell population proliferation [GO:0008285]; positive ...
ATPase activator activity [GO:0001671]; protein-macromolecule adaptor activity [GO:0030674]; sodium channel regulator activity [GO:0017080]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
FUNCTION: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
nan
nan
nan
P55259
MPHLMERMVGSGLLWLALVSCILTQASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGGVRMSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCEKACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFIIRDTILNINFQC...
537
59,479.9005
5.081372
0.080074
47.770577
-0.143762
0.266294
0.307263
0.350093
33
0.061
29
0.054
28
0.052
32
0.06
17
0.032
38
0.071
13
0.024
21
0.039
12
0.022
54
0.101
12
0.022
29
0.054
27
0.05
25
0.047
28
0.052
43
0.08
28
0.052
42
0.078
10
0.019
16
0.03
537
59,479.1
-22.946
-0.000386
P55259
GP2_HUMAN
Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)
Homo sapiens (Human)
537
59,480
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProt...
antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412]; innate immune response [GO:0045087]; neutrophil migration [GO:1990266]
antigen binding [GO:0003823]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProt...
FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typh...
DOMAIN: Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit. {ECO:0000250|UniProtKB:P07911}.
nan
nan
P54315
MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQ...
467
51,847.1853
5.474072
0.109208
23.328694
-0.252891
0.282655
0.30621
0.379015
29
0.062
13
0.028
27
0.058
28
0.06
28
0.06
39
0.084
10
0.021
26
0.056
29
0.062
39
0.084
7
0.015
22
0.047
25
0.054
16
0.034
15
0.032
30
0.064
35
0.075
26
0.056
8
0.017
15
0.032
467
51,846.38
-11.618
-0.000224
P54315
LIPR1_HUMAN
Inactive pancreatic lipase-related protein 1 (PL-RP1)
Homo sapiens (Human)
467
51,848
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; triglyceride catabolic process [GO:0019433]
calcium ion binding [GO:0005509]; lipoprotein lipase activity [GO:0004465]; phospholipase A1 activity [GO:0008970]; triacylglycerol lipase activity [GO:0004806]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
FUNCTION: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:19824014}.
nan
nan
nan
P55072
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV...
806
89,320.7757
5.138154
0.058313
39.696042
-0.347643
0.333747
0.297767
0.322581
65
0.081
12
0.015
62
0.077
68
0.084
31
0.038
63
0.078
10
0.012
59
0.073
47
0.058
69
0.086
20
0.025
32
0.04
43
0.053
26
0.032
58
0.072
40
0.05
32
0.04
53
0.066
3
0.004
13
0.016
806
89,320.05
-25.441
-0.000285
P55072
TERA_HUMAN
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Homo sapiens (Human)
806
89,322
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}. Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Present in the neuronal hyaline inclusion bodies specifically fou...
aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455];...
ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; M...
3.6.4.6
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence={ECO:0000269|PubMed:26471729};
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}. Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Present in the neuronal hyaline inclusion bodies specifically fou...
FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive...
DOMAIN: The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. {ECO:0000269|PubMed:24726327}.
nan
nan
P55072
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV...
806
89,320.7757
5.138154
0.058313
39.696042
-0.347643
0.333747
0.297767
0.322581
65
0.081
12
0.015
62
0.077
68
0.084
31
0.038
63
0.078
10
0.012
59
0.073
47
0.058
69
0.086
20
0.025
32
0.04
43
0.053
26
0.032
58
0.072
40
0.05
32
0.04
53
0.066
3
0.004
13
0.016
806
89,320.05
-25.441
-0.000285
Q01853
TERA_MOUSE
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Mus musculus (Mouse)
806
89,322
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P55072}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000250|UniProtKB:P55072}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000269|PubMed:33590678}. Note=Recruited to the cytoplasmic surface of the endopla...
aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455];...
ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; M...
3.6.4.6
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence={ECO:0000250|UniProtKB:P55072};
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P55072}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000250|UniProtKB:P55072}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000269|PubMed:33590678}. Note=Recruited to the cytoplasmic surface of the endopla...
FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive...
DOMAIN: The N-terminal domain shows evolutionary conservation with that of PEX1, and is able to bind phospholipids with a preference for phosphatidylinositol mono- and bisphosphates.; DOMAIN: The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. {ECO:0000250|UniProtKB:P55072}.
nan
nan
P54707
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGIL...
1,039
115,509.1536
6.123231
0.081809
31.661607
0.015592
0.316651
0.264678
0.405197
73
0.07
15
0.014
54
0.052
64
0.062
41
0.039
69
0.066
20
0.019
97
0.093
68
0.065
98
0.094
26
0.025
45
0.043
37
0.036
37
0.036
40
0.038
70
0.067
64
0.062
77
0.074
12
0.012
32
0.031
1,039
115,508.54
-10.537
-0.000091
P54707
AT12A_HUMAN
Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)
Homo sapiens (Human)
1,039
115,511
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376]
ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]
7.2.2.13; 7.2.2.19
nan
CATALYTIC ACTIVITY: Reaction=K(+)(out) + ATP + H2O + H(+)(in) = K(+)(in) + ADP + phosphate + 2 H(+)(out); Xref=Rhea:RHEA:22044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.19; Evidence={ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:748547...
nan
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellula...
nan
INDUCTION: Up-regulated by inflammatory cytokine IL13. {ECO:0000269|PubMed:29391451}.
nan
P54296
MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDD...
1,465
164,867.3391
5.817948
0.091468
39.09086
-0.448259
0.297611
0.286007
0.348805
95
0.065
27
0.018
91
0.062
113
0.077
58
0.04
93
0.063
37
0.025
66
0.045
94
0.064
106
0.072
28
0.019
44
0.03
71
0.048
59
0.04
82
0.056
120
0.082
83
0.057
122
0.083
23
0.016
53
0.036
1,465
164,866.86
-29.695
-0.00018
P54296
MYOM2_HUMAN
Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2)
Homo sapiens (Human)
1,465
164,869
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214]
kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
nan
nan
nan
P55196
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILD...
1,824
206,801.821
6.061617
0.060855
62.199731
-0.863816
0.332785
0.30318
0.281798
126
0.069
18
0.01
119
0.065
162
0.089
47
0.026
91
0.05
40
0.022
69
0.038
117
0.064
158
0.087
44
0.024
62
0.034
135
0.074
109
0.06
141
0.077
146
0.08
95
0.052
81
0.044
15
0.008
49
0.027
1,824
206,801.47
-23.156
-0.000112
P55196
AFAD_HUMAN
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Homo sapiens (Human)
1,824
206,804
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of...
actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
FUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton ...
DOMAIN: The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich C-terminal domain interacts with F-actin.
nan
nan
P55287
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITT...
796
87,964.2473
4.746874
0.079146
36.796608
-0.419598
0.268844
0.331658
0.350503
58
0.073
8
0.01
69
0.087
55
0.069
31
0.039
57
0.072
19
0.024
57
0.072
39
0.049
51
0.064
11
0.014
41
0.052
52
0.065
26
0.033
37
0.046
45
0.057
49
0.062
59
0.074
4
0.005
28
0.035
796
87,963.56
-47.48
-0.00054
P55287
CAD11_HUMAN
Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)
Homo sapiens (Human)
796
87,965
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331];...
beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation o...
DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
nan
nan
P54198
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPL...
1,017
111,833.8999
8.397023
0.05998
47.795477
-0.228712
0.320551
0.302852
0.344149
73
0.072
26
0.026
52
0.051
55
0.054
25
0.025
58
0.057
21
0.021
39
0.038
63
0.062
109
0.107
26
0.026
34
0.033
53
0.052
43
0.042
52
0.051
111
0.109
62
0.061
79
0.078
20
0.02
16
0.016
1,017
111,833.28
5.84
0.000052
P54198
HIRA_HUMAN
Protein HIRA (TUP1-like enhancer of split protein 1)
Homo sapiens (Human)
1,017
111,835
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [...
histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:00002...
nan
nan
nan
P55809
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYAN...
520
56,156.9802
7.133373
0.067308
25.424462
-0.1075
0.35
0.288462
0.344231
48
0.092
8
0.015
25
0.048
36
0.069
19
0.037
54
0.104
10
0.019
33
0.063
38
0.073
45
0.087
15
0.029
19
0.037
21
0.04
13
0.025
23
0.044
31
0.06
27
0.052
39
0.075
4
0.008
12
0.023
520
56,156.18
0.157
0.000003
P55809
SCOT1_HUMAN
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)
Homo sapiens (Human)
520
56,158
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
adipose tissue development [GO:0060612]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to act...
identical protein binding [GO:0042802]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]
2.8.3.5
nan
CATALYTIC ACTIVITY: Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence={ECO:0000269|PubMed:10964512}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24565; Evidence={ECO:0000305|...
PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. {ECO:0000305|PubMed:10964512}.
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
FUNCTION: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further...
nan
nan
nan
P53804
MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQ...
2,025
229,866.3225
7.531075
0.078519
49.13003
-0.589531
0.348148
0.285432
0.315062
120
0.059
55
0.027
105
0.052
176
0.087
76
0.038
91
0.045
47
0.023
118
0.058
199
0.098
180
0.089
30
0.015
100
0.049
109
0.054
98
0.048
84
0.041
173
0.085
74
0.037
107
0.053
21
0.01
62
0.031
2,025
229,866.12
-3.624
-0.000016
P53804
TTC3_HUMAN
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Homo sapiens (Human)
2,025
229,869
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleava...
protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]
ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
2.3.2.27
nan
CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30696809};
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30696809}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleava...
FUNCTION: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling afte...
nan
INDUCTION: Up-regulated by TGFB1 signaling. {ECO:0000269|PubMed:30696809}.
nan
P55327
MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKFGLLRTDPVPEEGEDVAATISATETLSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL
224
24,326.7149
4.789788
0.058036
63.524107
-0.652679
0.40625
0.299107
0.308036
20
0.089
1
0.004
10
0.045
27
0.121
7
0.031
14
0.062
1
0.004
6
0.027
21
0.094
21
0.094
2
0.009
8
0.036
11
0.049
11
0.049
5
0.022
24
0.107
17
0.076
12
0.054
1
0.004
5
0.022
224
24,325.82
-10.127
-0.000416
P55327
TPD52_HUMAN
Tumor protein D52 (Protein N8)
Homo sapiens (Human)
224
24,327
nan
anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; positive regulation of cell population proliferation [GO:0008284]; secretion [GO:0046903]
calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]
nan
nan
nan
nan
nan
nan
nan
nan
nan
P53618
MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPAHERVLQD...
953
107,141.0207
5.721038
0.057712
37.808814
-0.091186
0.378804
0.242392
0.377754
75
0.079
20
0.021
58
0.061
72
0.076
28
0.029
29
0.03
22
0.023
67
0.07
69
0.072
117
0.123
28
0.029
44
0.046
39
0.041
34
0.036
42
0.044
61
0.064
50
0.052
71
0.075
4
0.004
23
0.024
953
107,140.36
-20.201
-0.000189
P53618
COPB_HUMAN
Coatomer subunit beta (Beta-coat protein) (Beta-COP)
Homo sapiens (Human)
953
107,142
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:7573041}; Peripheral membrane protein {ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:20056612}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, COPI...
endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]
structural molecule activity [GO:0005198]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:7573041}; Peripheral membrane protein {ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:20056612}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, COPI...
FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membra...
nan
nan
nan
P55273
MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
166
17,699.9672
5.691141
0.024096
28.65241
-0.000602
0.373494
0.26506
0.343373
21
0.127
0
0
12
0.072
9
0.054
4
0.024
15
0.09
8
0.048
3
0.018
3
0.018
25
0.151
4
0.024
3
0.018
7
0.042
8
0.048
12
0.072
7
0.042
9
0.054
16
0.096
0
0
0
0
166
17,699.04
-4.67
-0.000264
P55273
CDN2D_HUMAN
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Homo sapiens (Human)
166
17,700
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
autophagic cell death [GO:0048102]; DNA synthesis involved in DNA repair [GO:0000731]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intrinsic apoptotic...
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
FUNCTION: Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.
nan
nan
nan
P53567
MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ
150
16,408.1944
9.772972
0.013333
45.688667
-0.952
0.346667
0.326667
0.24
12
0.08
0
0
7
0.047
9
0.06
1
0.007
10
0.067
4
0.027
5
0.033
15
0.1
13
0.087
3
0.02
11
0.073
6
0.04
14
0.093
8
0.053
15
0.1
7
0.047
9
0.06
0
0
1
0.007
150
16,407.27
8.153
0.000497
P53567
CEBPG_HUMAN
CCAAT/enhancer-binding protein gamma (C/EBP gamma)
Homo sapiens (Human)
150
16,408
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53568}.
B cell differentiation [GO:0030183]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; integrated stress response signaling [GO:0140467]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxici...
DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regula...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53568}.
FUNCTION: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the ...
nan
nan
nan
P52961
MQMPAMMSLLLVSVGLMEALQAQSHPITRRDLFSQEIQLDMALASFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTRPSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTFFGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYNCEYIKDKKCKSGPCHLDNSAMGQSPLSAVWSLLLLLWFLVVRAF...
327
36,334.243
8.526089
0.107034
46.081651
-0.113456
0.336391
0.272171
0.33945
37
0.113
6
0.018
11
0.034
15
0.046
20
0.061
23
0.07
13
0.04
8
0.024
9
0.028
41
0.125
8
0.024
7
0.021
23
0.07
19
0.058
20
0.061
25
0.076
13
0.04
14
0.043
7
0.021
8
0.024
327
36,333.38
3.599
0.000099
P52961
NAR1_HUMAN
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 1) (ARTC1) (Mono(ADP-ribosyl)transferase 1) (CD antigen CD296)
Homo sapiens (Human)
327
36,335
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
nan
NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]
2.4.2.31
nan
CATALYTIC ACTIVITY: Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31;
nan
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
FUNCTION: Has ADP-ribosyltransferase activity toward GLP1R. {ECO:0000269|PubMed:21901419}.
nan
nan
nan
P52952
MFPSPALTPTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPEAAAPGLPELRAELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPAYGVGLNPYGYNAYPAYPGYGGAACSPGYSCTAAYPAGPSPAQPATAAANNNFVNFGVGDLNAVQSPGIPQSNSGVSTLHG...
324
34,917.2948
9.461267
0.083333
66.035833
-0.464815
0.351852
0.317901
0.262346
52
0.16
7
0.022
10
0.031
17
0.052
10
0.031
20
0.062
1
0.003
5
0.015
15
0.046
28
0.086
2
0.006
11
0.034
41
0.127
17
0.052
25
0.077
21
0.065
10
0.031
15
0.046
2
0.006
15
0.046
324
34,916.43
12.927
0.00037
P52952
NKX25_HUMAN
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Homo sapiens (Human)
324
34,918
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29899023}.
adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell ...
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29899023}.
FUNCTION: Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular ca...
DOMAIN: The homeobox domain binds to double-stranded DNA (PubMed:22849347). {ECO:0000269|PubMed:22849347}.
nan
nan
P52849
MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGAAGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDI...
883
100,873.3654
8.812651
0.11778
46.791993
-0.261042
0.281993
0.289921
0.400906
46
0.052
10
0.011
41
0.046
43
0.049
50
0.057
60
0.068
33
0.037
33
0.037
30
0.034
117
0.133
13
0.015
27
0.031
68
0.077
35
0.04
63
0.071
60
0.068
52
0.059
48
0.054
17
0.019
37
0.042
883
100,872.7
9.772
0.000097
P52849
NDST2_HUMAN
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)]
Homo sapiens (Human)
883
100,875
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin proteoglycan biosynthetic process [GO:0030210]; mast cell mediated immunity [GO:0002448]; regulation of angiotensin levels in blood [GO:0002002]
deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; heparan sulfate N-sulfotransferase activity [GO:0015016]; N-acetylglucosamine deacetylase activity [GO:0050119]
2.8.2.-; 2.8.2.8; 3.-.-.-
nan
CATALYTIC ACTIVITY: Reaction=alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:21980, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:14602, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI...
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis.
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in hepari...
nan
nan
nan
P54098
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKH...
1,239
139,560.415
6.46057
0.082324
51.956578
-0.490315
0.334948
0.274415
0.317998
103
0.083
20
0.016
57
0.046
91
0.073
32
0.026
92
0.074
29
0.023
39
0.031
58
0.047
129
0.104
34
0.027
27
0.022
89
0.072
88
0.071
82
0.066
75
0.061
53
0.043
71
0.057
37
0.03
33
0.027
1,239
139,559.86
-8.912
-0.000064
P54098
DPOG1_HUMAN
DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)
Homo sapiens (Human)
1,239
139,562
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA replication proofreading [GO:0045004]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]
3'-5' exonuclease activity [GO:0008408]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]
2.7.7.7; 3.1.11.-; 4.2.99.-
nan
CATALYTIC ACTIVITY: Reaction=DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate; Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:11477093, ECO:0000269...
nan
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
FUNCTION: Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates (PubMed:11477093, PubMe...
DOMAIN: The polymerase domain encompasses three conserved active site motifs: Pol A (residues 887-896), Pol B (residues 943-958) and Pol C (residues 1134-1141). Binds the incoming dNTPs and undergoes an open to close coformation change to catalyze the formation of phosphodiester bond. {ECO:0000269|PubMed:26056153, ECO:...
nan
nan
P52799
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQE...
333
36,922.7708
9.036872
0.084084
45.298198
-0.35015
0.249249
0.339339
0.36036
15
0.045
8
0.024
17
0.051
13
0.039
9
0.027
25
0.075
6
0.018
25
0.075
24
0.072
25
0.075
6
0.018
18
0.054
21
0.063
13
0.039
15
0.045
32
0.096
20
0.06
22
0.066
4
0.012
15
0.045
333
36,921.92
8.977
0.000243
P52799
EFNB2_HUMAN
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Homo sapiens (Human)
333
36,923
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:...
ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional sign...
nan
nan
nan
P52789
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLF...
917
102,378.7571
5.7095
0.067612
34.933152
-0.19084
0.343511
0.254089
0.352236
57
0.062
25
0.027
62
0.068
73
0.08
41
0.045
83
0.091
26
0.028
46
0.05
55
0.06
92
0.1
38
0.041
25
0.027
21
0.023
29
0.032
58
0.063
42
0.046
52
0.057
71
0.077
6
0.007
15
0.016
917
102,378.06
-23.779
-0.000232
P52789
HXK2_HUMAN
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Homo sapiens (Human)
917
102,380
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction...
apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glu...
ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396]
2.7.1.1
nan
CATALYTIC ACTIVITY: Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence={ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}; Physiol...
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:29298880}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:29298880}.
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction...
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose...
DOMAIN: The N- and C-terminal halves of the protein contain a hexokinase domain (PubMed:29298880). In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity (PubMed:29298880). The region connecting the two hexokinase domains is required for the catalytic activity...
nan
nan
P55157
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNL...
894
99,350.0112
8.612025
0.074944
42.001465
-0.177069
0.345638
0.269575
0.373602
63
0.07
11
0.012
40
0.045
60
0.067
34
0.038
55
0.062
15
0.017
62
0.069
69
0.077
98
0.11
19
0.021
36
0.04
26
0.029
43
0.048
39
0.044
84
0.094
49
0.055
58
0.065
4
0.004
29
0.032
894
99,349.36
7.87
0.000079
P55157
MTP_HUMAN
Microsomal triglyceride transfer protein large subunit
Homo sapiens (Human)
894
99,351
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|Pu...
cholesterol homeostasis [GO:0042632]; chylomicron assembly [GO:0034378]; circadian rhythm [GO:0007623]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle remodeling [G...
apolipoprotein binding [GO:0034185]; ceramide 1-phosphate transfer activity [GO:1902388]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphol...
nan
nan
CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence={ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:8876250}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence={ECO:0000305|PubMed...
nan
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|Pu...
FUNCTION: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that...
nan
INDUCTION: Positively regulated by cholesterol and negatively regulated by insulin. {ECO:0000269|PubMed:7961826}.
nan
P54289
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKD...
1,103
124,566.5287
5.119681
0.104261
35.000562
-0.33282
0.285585
0.31097
0.381686
67
0.061
20
0.018
77
0.07
64
0.058
49
0.044
65
0.059
11
0.01
68
0.062
66
0.06
101
0.092
17
0.015
77
0.07
52
0.047
46
0.042
48
0.044
72
0.065
60
0.054
77
0.07
17
0.015
49
0.044
1,103
124,565.95
-28.712
-0.00023
P54289
CA2D1_HUMAN
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
Homo sapiens (Human)
1,103
124,568
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35293990}.
calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular respon...
metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35293990}.
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250, ECO:0000269|PubMed:35293990}.
DOMAIN: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO:0000250}.
nan
nan
P53674
MSQAAKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRDKQWHLEGSFPVLATEPPK
252
28,023.054
8.589203
0.123016
41.384524
-0.544841
0.269841
0.345238
0.31746
21
0.083
1
0.004
10
0.04
16
0.063
14
0.056
24
0.095
3
0.012
8
0.032
11
0.044
15
0.06
5
0.02
9
0.036
20
0.079
11
0.044
17
0.067
24
0.095
12
0.048
14
0.056
8
0.032
9
0.036
252
28,022.16
2.948
0.000105
P53674
CRBB1_HUMAN
Beta-crystallin B1 (Beta-B1 crystallin)
Homo sapiens (Human)
252
28,023
nan
lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]
structural constituent of eye lens [GO:0005212]
nan
nan
nan
nan
nan
FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.
DOMAIN: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
nan
nan
P52739
MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKK...
623
71,421.2119
5.101891
0.060995
52.417207
-0.6687
0.373997
0.210273
0.314607
38
0.061
18
0.029
31
0.05
88
0.141
24
0.039
24
0.039
33
0.053
26
0.042
46
0.074
49
0.079
12
0.019
20
0.032
18
0.029
36
0.058
25
0.04
38
0.061
36
0.058
47
0.075
4
0.006
10
0.016
623
71,420.43
-48.391
-0.000678
P52739
ZN131_HUMAN
Zinc finger protein 131
Homo sapiens (Human)
623
71,422
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17306895, ECO:0000269|PubMed:22467880, ECO:0000269|PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.
negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17306895, ECO:0000269|PubMed:22467880, ECO:0000269|PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.
FUNCTION: Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}.
nan
nan
nan
P52597
MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIE...
415
45,671.3475
5.376253
0.106024
37.882892
-0.471566
0.272289
0.33253
0.313253
26
0.063
6
0.014
22
0.053
33
0.08
20
0.048
51
0.123
13
0.031
15
0.036
16
0.039
24
0.058
14
0.034
11
0.027
17
0.041
15
0.036
24
0.058
37
0.089
19
0.046
28
0.067
2
0.005
22
0.053
415
45,670.52
-14.42
-0.000316
P52597
HNRPF_HUMAN
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]
Homo sapiens (Human)
415
45,672
SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]
RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-...
DOMAIN: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
nan
nan
P54105
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
237
26,215.0243
4.050028
0.080169
49.968819
-0.656118
0.341772
0.337553
0.299578
16
0.068
3
0.013
25
0.105
32
0.135
9
0.038
19
0.08
6
0.025
5
0.021
5
0.021
21
0.089
7
0.03
3
0.013
13
0.055
9
0.038
8
0.034
20
0.084
14
0.059
12
0.051
1
0.004
9
0.038
237
26,214.13
-43.219
-0.001649
P54105
ICLN_HUMAN
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
Homo sapiens (Human)
237
26,215
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spliceosomal snRNP assembly [GO:0000387]
RNA binding [GO:0003723]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosom...
nan
nan
nan
P53701
MGLSPSAPAVAVQASNASASPPSGCPMHEGKMKGCPVNTEPSGPTCEKKTYSVPAHQERAYEYVECPIRGTAAENKENLDPSNLMPPPNQTPAPDQPFALSTVREESSIPRADSEKKWVYPSEQMFWNAMLKKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKDYQFTILDVRPALDSLSAVWDRMKVAWWRWTS
268
30,601.2463
6.248902
0.104478
60.752239
-0.733955
0.309701
0.320896
0.279851
23
0.086
7
0.026
14
0.052
21
0.078
5
0.019
14
0.052
5
0.019
13
0.049
18
0.067
12
0.045
9
0.034
13
0.049
24
0.09
9
0.034
15
0.056
21
0.078
9
0.034
13
0.049
12
0.045
11
0.041
268
30,600.36
-1.896
-0.000062
P53701
CCHL_HUMAN
Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase)
Homo sapiens (Human)
268
30,602
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:17033964}. Membrane {ECO:0000269|PubMed:23150584}; Lipid-anchor {ECO:0000305|PubMed:25255805, ECO:0000305|PubMed:25807930}.
animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]; respiratory electron transport chain [GO:0022904]
heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872]
4.4.1.17
nan
CATALYTIC ACTIVITY: Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b; Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726, ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17; Evidence={ECO:0000269|PubMed:23150584}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22650; Evid...
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:17033964}. Membrane {ECO:0000269|PubMed:23150584}; Lipid-anchor {ECO:0000305|PubMed:25255805, ECO:0000305|PubMed:25807930}.
FUNCTION: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. {ECO:0000269|PubMed:23150584}.
nan
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
P51970
NDUA8_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Homo sapiens (Human)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}. Mitochondrion {ECO:0000269|PubMed:23676665}.
aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]
NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}. Mitochondrion {ECO:0000269|PubMed:23676665}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The imm...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000305|PubMed:21310150}.
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
Q0MQB1
NDUA8_PANTR
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Pan troglodytes (Chimpanzee)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
mitochondrial electron transport, NADH to ubiquinone [GO:0006120]
protein-containing complex binding [GO:0044877]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000250|UniProtKB:P51970}.
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
Q0MQB0
NDUA8_GORGO
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Gorilla gorilla gorilla (Western lowland gorilla)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
mitochondrial electron transport, NADH to ubiquinone [GO:0006120]
nan
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000250|UniProtKB:P51970}.
nan
nan
P51956
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSH...
506
57,704.0016
6.724473
0.075099
46.920949
-0.605534
0.34585
0.296443
0.328063
24
0.047
9
0.018
25
0.049
44
0.087
16
0.032
29
0.057
14
0.028
26
0.051
40
0.079
54
0.107
13
0.026
31
0.061
25
0.049
19
0.038
27
0.053
40
0.079
24
0.047
24
0.047
8
0.016
14
0.028
506
57,703.2
-1.83
-0.000032
P51956
NEK3_HUMAN
Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3)
Homo sapiens (Human)
506
57,705
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]
ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
2.7.11.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=L-threonyl-[protein]...
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells...
nan
nan
nan
P51946
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLV...
323
37,643.0253
6.726065
0.095975
50.644923
-0.378947
0.393189
0.232198
0.362229
20
0.062
8
0.025
14
0.043
31
0.096
14
0.043
7
0.022
8
0.025
14
0.043
24
0.074
42
0.13
10
0.031
15
0.046
15
0.046
10
0.031
20
0.062
24
0.074
13
0.04
17
0.053
2
0.006
15
0.046
323
37,642.15
-0.93
-0.000025
P51946
CCNH_HUMAN
Cyclin-H (MO15-associated protein) (p34) (p37)
Homo sapiens (Human)
323
37,643
SUBCELLULAR LOCATION: Nucleus.
protein stabilization [GO:0050821]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367]
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; kinase activity [GO:0016301]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus.
FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of th...
nan
nan
nan
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