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Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.
Inhibition of histone deacetylase (HDAC) has been regarded as a potential therapeutic approach for treatment of multiple diseases including cancer. Based on pharmacophore model of HDAC inhibitors, a series of quinoline-base... | {
"pile_set_name": "PubMed Abstracts"
} |
Endoscopic robot-assisted extended thymectomy by subxiphoid approach with sternal lifting: feasibility in the pig.
In the search for novel approaches to thoracoscopic thymectomy we assessed the feasibility of a subxiphoid approach using computer-enhanced instruments and sternal lifting. In 12 pigs, after lifting of the... | {
"pile_set_name": "PubMed Abstracts"
} |
Autosomal dominant brachydactyly, coloboma and anterior segment dysgenesis.
A three-generation family presenting with ocular developmental abnormalities, including anterior segment dysgenesis and coloboma, associated with brachydactyly and clinodactyly is presented. Several conditions incorporating ocular and bony limb... | {
"pile_set_name": "PubMed Abstracts"
} |
N-methyl-D-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats.
Estrogen interacts with N-methyl-d-aspartate (NMDA) receptors to regulate multiple aspects of morphological and functional plasticity. In the hippocampus, estrogens increase both dendritic spine density an... | {
"pile_set_name": "PubMed Abstracts"
} |
Marked resorption of the thumb proximal phalanx following open reduction and K-wire fixation of a phalangeal neck fracture in a child: case report.
We report on a child with nonunion of a phalangeal neck fracture of the thumb following open reduction and K-wire fixation. There was progressive resorption of the proximal... | {
"pile_set_name": "PubMed Abstracts"
} |
Allotype analysis to distinguish the origin of varicella-zoster virus immunoglobulin G after allogeneic stem cell transplantation.
Varicella-zoster virus (VZV) reactivation is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT). Although previous studies have revealed that cellular i... | {
"pile_set_name": "PubMed Abstracts"
} |
Effects of GAC layer on the performance of gravity-driven membrane filtration (GDM) system for rainwater recycling.
Gravity-driven membrane filtration (GDM) is promising for decentralized rainwater recycling, owing to low maintenance and energy consumption. However, the organic removal by GDM process is sometimes undes... | {
"pile_set_name": "PubMed Abstracts"
} |
Solar photothermochemical reaction and supercritical CO2 work up for a fully green process of preparation of pure p-nitrobenzyl bromide.
It has been reported by us recently that p-nitrobenzyl bromide (PNBBr) can be synthesized from p-nitrotoluene (PNT) in high isolated yield with respect to available bromine in 2:1 Br(... | {
"pile_set_name": "PubMed Abstracts"
} |
Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity.
Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) share some pathophysiologic bases as evidenced by individual and familial polyautoimmunity and com... | {
"pile_set_name": "PubMed Abstracts"
} |
Effect of treatment with dexamethasone on protein intake in adult and old Lou/c/jall rats.
A deleterious decrease of protein intake had been evidenced in Lou/c/jall rats during ageing. This result could be induced by an impaired regulation of feeding behaviour. Glucocorticoids inducing specific amino-acid needs for glu... | {
"pile_set_name": "PubMed Abstracts"
} |
Accuracy of MR imaging for revealing residual breast cancer in patients who have undergone neoadjuvant chemotherapy.
Our study investigated the usefulness of contrast-enhanced MR imaging for accurately measuring the size of residual tumor after patients have undergone neoadjuvant (pre-operative) chemotherapy. The imagi... | {
"pile_set_name": "PubMed Abstracts"
} |
Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.
Arrhythmia-prone subepicardial border zone (EBZ) tissue demonstrates decreased G protein receptor kinase 2 (GRK2) activity and increased sensitivity to isoproterenol 6-24 h after coronary artery l... | {
"pile_set_name": "PubMed Abstracts"
} |
Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas.
Amylin, a 37-amino acid polypeptide, is the main component of amyloid deposits in the islets of Langerhans, and has been identified in the B-cell secretory granules. We have investigated the effect of rat amyl... | {
"pile_set_name": "PubMed Abstracts"
} |
Mechanical modeling of biological cells in microinjection.
Microinjection is an effective technique to introduce foreign materials into a biological cell. Although some semi-automatic and fully-automatic microinjection systems have been developed, a full understanding of the mechanical response of biological cells to i... | {
"pile_set_name": "PubMed Abstracts"
} |
Reduced beta 2-adrenoceptor responsiveness in exercise-induced asthma.
Beta-adrenoceptor responsiveness was studied both in vivo and in vitro in patients with exercise-induced asthma (EIA), asthmatic patients without EIA (NEIA), and control subjects. All subjects were age- and sex-matched and without medication at leas... | {
"pile_set_name": "PubMed Abstracts"
} |
Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces.
Binding of linear fragments of protein antigens to class I or class II molecules of the MHC is necessary for the stimulation of a cellular immune response. This report describes the binding of a biotinylated T cell determinant from influe... | {
"pile_set_name": "PubMed Abstracts"
} |
[Update on diagnosis and treatment of normotensive hydrocephalus (chronic hydrocephalus of the adult)].
Normal pressure hydrocephalus, or adult chronic hydrocephalus, is a relatively unknown entity. Classically, this disease is characterized by progressive dementia, gait disturbance, and urinary incontinence. Despite a... | {
"pile_set_name": "PubMed Abstracts"
} |
Combination of photodynamic therapy and temozolomide on glioma in a rat C6 glioma model.
For glioma, temozolomide (TMZ) is a commonly used chemotherapy drug and photodynamic therapy (PDT) is an important adjuvant therapy. The aim of this study was to evaluate the effect of their combination for the treatment of glioma.... | {
"pile_set_name": "PubMed Abstracts"
} |
Two effects of context on the presence/absence of connecting segments.
Stimulus A consisted of two proximal brackets with colinear lines separated by small gaps. Stimulus B was a square-like rectangle produced by inserting connecting segments into the gaps. Stimulus A was frequently represented as B (i.e., as closed). ... | {
"pile_set_name": "PubMed Abstracts"
} |
Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake.
We have recently shown that accumulation in mouse kidneys of technetium-99m labeled phosphorodiamidate morpholinos (MORFs) increases with the number of cytosines in the base sequence. To improve tumor/kidney ratios in tumored ... | {
"pile_set_name": "PubMed Abstracts"
} |
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models.
The objective of this study was to determine the tumor distribution of temozolomide, an alkylating agent, in the absence and presence of the angiogene... | {
"pile_set_name": "PubMed Abstracts"
} |
Orientational distributions and nematic order of rodlike magnetic nanoparticles in dispersions.
Using small-angle neutron scattering (SANS), we have investigated the orientational order of iron nanoparticles dispersed in cyclohexanone. The particles have rodlike shape and size distributions with an average length of 20... | {
"pile_set_name": "PubMed Abstracts"
} |
A score test for testing a zero-inflated Poisson regression model against zero-inflated negative binomial alternatives.
Count data often show a higher incidence of zero counts than would be expected if the data were Poisson distributed. Zero-inflated Poisson regression models are a useful class of models for such data,... | {
"pile_set_name": "PubMed Abstracts"
} |
Patient and parental scar assessment after single incision versus standard 3-port laparoscopic appendectomy: long-term follow-up from a prospective randomized trial.
Single site laparoscopy for appendectomy is a technique with several case series suggesting a cosmetic advantage, but without prospective comparative data... | {
"pile_set_name": "PubMed Abstracts"
} |
Acute relief of epigastric pain by antacid in duodenal ulcer patients.
Thirty-six duodenal ulcer patients participated in a randomized controlled trial of the immediate effect of a liquid antacid preparation (Link) and placebo on epigastric pain. The patients recorded the effect of a total of 143 doses of antacid and 1... | {
"pile_set_name": "PubMed Abstracts"
} |
Fetal free thyroxine concentrations in pregnant women with autoimmune thyroid disease.
Fetuses from mothers with autoimmune thyroid disease (AITD) may be affected by antithyroid antibodies, antithyroid drugs, and iodine. The study correlated fetal free T(4) (fT4) with fetal ultrasound parameters and maternal thyroid fu... | {
"pile_set_name": "PubMed Abstracts"
} |
Midwifery and society in restoration York.
This article is a micro-historical study of the social networks of an elite mid-wife in seventeenth-century England, and discusses the implications of these networks for our understanding of early modem midwifery. Bridget Hodgson was the daughter-in-law to the former Lord Mayo... | {
"pile_set_name": "PubMed Abstracts"
} |
Nosocomial bacterial and fungal meningitis in children; an eight year national survey reporting 101 cases. Pediatric Nosocomial Meningitis Study Group.
One hundred and one cases of nosocomial meningitis in children from a national survey over 8 years have been analyzed for risk factors and outcome. From 101 cases, 115 ... | {
"pile_set_name": "PubMed Abstracts"
} |
Thyroid gland ectopias.
Failures of descent of the medial anlage of the thyroid and incomplete obliteration of its vertical tract lead to midline or near-midline ectopias such as lingual thyroid and thyroglossal cysts. Each poses special diagnostic and therapeutic considerations. "Ectopias" of the thyroid gland lateral... | {
"pile_set_name": "PubMed Abstracts"
} |
Factors influencing reticulophagocytic function in insulin-treated diabetes.
The splenic component of reticulophagocytic function (RPF) was examined in 29 insulin-treated diabetic subjects (13 type I and 16 type II) by measurement of clearance of altered, radiolabeled, autologous erythrocytes. Double-isotope studies we... | {
"pile_set_name": "PubMed Abstracts"
} |
Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering.
In order to induce the chondrogenesis of mesenchymal stem cells (MSCs) in tissue engineering, a variety of growth factors have been adapted and encouraging results have been demonstrated. In this study, we developed a delivery s... | {
"pile_set_name": "PubMed Abstracts"
} |
Long-term care facility policies on life-sustaining treatments and advance directives in Canada.
To describe the prevalence and content of long-term care facility policies regarding the use of life-sustaining treatments (cardiopulmonary resuscitation (CPR), artificial hydration and nutrition, dialysis, antibiotics for ... | {
"pile_set_name": "PubMed Abstracts"
} |
Isolated collagenoma: a case report with a review of connective tissue nevi of the collagen type.
A 22-year-old male had had five skin colored tumorous growths on the mid-palm, ring and little fingers of the right hand for the last 15 years. Histopathological examination with hematoxylin and eosin and special stains co... | {
"pile_set_name": "PubMed Abstracts"
} |
Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments.
Classical theory predicts that branching defects are unavoidable in large dendritic molecules when steric congestion is important. Here we report first experimental evidence of this effect via labelling measurements ... | {
"pile_set_name": "PubMed Abstracts"
} |
Microbiologic changes during antimicrobial treatment and rate of relapse of distal respiratory tract infections in foals.
Despite the high incidence of distal respiratory tract infection of undetermined cause on farms, to our knowledge, the microbiologic effects of conventional antimicrobial treatment for this conditio... | {
"pile_set_name": "PubMed Abstracts"
} |
Examining the Association Between Apparent Temperature and Mental Health-Related Emergency Room Visits in California.
The association between ambient temperature and morbidity has been explored previously. However, the association between temperature and mental health-related outcomes, including violence and self-harm,... | {
"pile_set_name": "PubMed Abstracts"
} |
To the editor in reply to Dr. Crow's letter.
We are delighted that our discovery of autoantibodies directed against LINE-1 retroelement-encoded p40/ORF1p in SLE patients (1) has been so rapidly replicated and we thank Dr. Crow for her excellent summary of our findings. Her group's detection of LINE-1 mRNA and immunorea... | {
"pile_set_name": "PubMed Abstracts"
} |
On the diversity of insulin secretion and sensitivity in subjects with impaired glucose tolerance.
Insulin secretion and sensitivity are basic characteristics determining the glucose tolerance. The aim of this study was to investigate if derangements in these two main characteristics were generally found in subjects wi... | {
"pile_set_name": "PubMed Abstracts"
} |
Diagnostic tests and information theory.
Our previous article showed that the discriminating properties of most diagnostic tests in medicine can be characterized by assuming that tests separate disordered and nondisordered individuals into two overlapping, normal distributions with different means and standard deviatio... | {
"pile_set_name": "PubMed Abstracts"
} |
Childhood antecedents of personality disorder: an alternative perspective.
One of the fundamental limitations of the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, Text Revision (DSM-IV-TR) categorical model of personality disorder classification has been the lack of a strong scientific foundatio... | {
"pile_set_name": "PubMed Abstracts"
} |
Contrast-enhanced US-guided radiofrequency ablation of hepatocellular carcinoma.
Contrast-enhanced ultrasound (US) has been shown to be an efficient imaging modality in guiding radiofrequency (RF) ablation of hepatocellular carcinomas (HCC). The purpose of the present study was to assess the usefulness of contrast-enha... | {
"pile_set_name": "PubMed Abstracts"
} |
Antibiosis-type insect resistance in transgenic plants expressing a teratocyte secretory protein (TSP14) gene from a hymenopteran endoparasite (Microplitis croceipes).
We have isolated a teratocyte secretory protein (TSP14) gene product from a hymenopteran endoparasite that disrupts the growth of lepidopteran insect la... | {
"pile_set_name": "PubMed Abstracts"
} |
Rhinolithiasis: review of 21 cases.
Rhinolithiasis is masses that result from the deposition of salts around an intranasal foreign body. Rhinoliths are rare and rhinolithiasis is generally reported in the literature in single case studies. This study presents 21 cases of rhinolithiasis with a large series of clinical f... | {
"pile_set_name": "PubMed Abstracts"
} |
Sun-induced chlorophyll fluorescence from high-resolution imaging spectroscopy data to quantify spatio-temporal patterns of photosynthetic function in crop canopies.
Passive detection of sun-induced chlorophyll fluorescence (SIF) using spectroscopy has been proposed as a proxy to quantify changes in photochemical effic... | {
"pile_set_name": "PubMed Abstracts"
} |
The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures.
RADA16 self-assembling peptide nanofiber scaffolds (SAPNSs) have been shown to have positive effects on neural regeneration following injury to the central nervous system in vivo, but mechanisms are uncl... | {
"pile_set_name": "PubMed Abstracts"
} |
Clinical and economic evaluation of the Trellis-8 infusion catheter for deep vein thrombosis.
To summarize the preliminary experience with the Trellis-8 infusion catheter (TIC) in the treatment of deep venous thrombosis (DVT) and compare the outcome to that with catheter-directed thrombolysis (CDT) by using a meta-anal... | {
"pile_set_name": "PubMed Abstracts"
} |
Clinical guides to preventing ethical conflicts between pregnant women and their physicians.
We provide a justification for preventive ethics in obstetric practice. Four clinical guides to resolving ethical conflicts between pregnant women and their physicians can be identified: (1) informed consent as an ongoing dialo... | {
"pile_set_name": "PubMed Abstracts"
} |
Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death.
Despite abundant evidence for changes in mitochondrial membrane permeability in tumor necrosis factor (TNF)-mediated cell death, the role of plasma membrane ion channels in this process remains unclear. These studies... | {
"pile_set_name": "PubMed Abstracts"
} |
The many postures of noncanonical Wnt signaling in development and diseases.
Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays... | {
"pile_set_name": "PubMed Abstracts"
} |
DWI filtering using joint information for DTI and HARDI.
The filtering of the Diffusion Weighted Images (DWI) prior to the estimation of the diffusion tensor or other fiber Orientation Distribution Functions (ODF) has been proved to be of paramount importance in the recent literature. More precisely, it has been eviden... | {
"pile_set_name": "PubMed Abstracts"
} |
[Diagnosis of interstitial cystitis].
Interstitial cystitis (IC) represents a rare and complex inflammatory bladder condition in which diagnostics can be challenging. Strict NIH criteria for its diagnosis were designed for research purposes. Their routine application would miss large proportions of IC patients. When IC... | {
"pile_set_name": "PubMed Abstracts"
} |
New nucleoside-5'-alkylphosphonophosphates and related compounds containing 2'-deoxycytidine, thymidine and adenosine as nucleoside component. Syntheses and their effects on tumor cell growth in vitro.
Recent studies have shown that phosphono analogs of cytidine-5'-diphosphate diacylglycerol (CDP-DAG) possessing a stru... | {
"pile_set_name": "PubMed Abstracts"
} |
[Equine motor neuron disease: a review based on a case report].
A 10-year-old, non-pregnant Dutch Warmblood mare was referred to the Department of Equine Science because of chronic weight loss, despite good appetite, and dullness. Clinical examination revealed muscle atrophy, trembling of the limb muscles, an abnormal ... | {
"pile_set_name": "PubMed Abstracts"
} |
Risk of recurrence of fetal chromosomal aberrations: analysis of trisomy 21, trisomy 18, trisomy 13, and 45,X in 1,076 Japanese mothers.
To evaluate the risk of recurrence of fetal chromosomal aberrations in women who had offspring with numeric chromosomal abnormalities. This collaborative study consisted of 1,076 Japa... | {
"pile_set_name": "PubMed Abstracts"
} |
Reassessing the impact of cytomegalovirus infection in kidney and kidney-pancreas transplantation.
New antiviral agents and practice guidelines have been implemented to address cytomegalovirus (CMV) infection in organ transplantation. We hypothesized that such measures would reduce rates of symptomatic CMV infection, C... | {
"pile_set_name": "PubMed Abstracts"
} |
Making the invisible body visible. Bone scans, osteoporosis and women's bodily experiences.
The imaging technology of bone scans allows visualization of the bone structure, and determination of a numerical value. Both these are subjected to professional interpretation according to medical (epidemiological) evidence to ... | {
"pile_set_name": "PubMed Abstracts"
} |
Model-based advanced process control of coagulation.
The drinking water treatment industry has seen a recent increase in the use of artificial neural networks (ANNs) for process modelling and offline process control tools and applications. While conceptual frameworks for integrating the ANN technology into the real-tim... | {
"pile_set_name": "PubMed Abstracts"
} |
Critical incident reporting in the intensive care unit.
Critical incident reporting was introduced into the intensive care unit (ICU) as part of the development of a quality assurance programme within our department. Over a 3-year period 281 critical incidents were reported. Factors relating to causation, detection and... | {
"pile_set_name": "PubMed Abstracts"
} |
Cognitive approaches to summary measurement: its application to the measurement of diversity in health-related quality of life assessments.
This paper describes elements of a cognitive approach to summary measurement, as it is applied to health-related quality of life (HRQOL) assessment. A summary measure, by its very ... | {
"pile_set_name": "PubMed Abstracts"
} |
Pathophysiology of vascular dementia and white matter changes.
Vascular dementia (VaD) can be defined as a dementia syndrome likely to be the consequence of lesions of the brain, vascular in origin, irrespective of their ischemic, hemorrhagic or hypoxic nature. Six subtypes (1) multi-infarct dementia, (2) strategic sin... | {
"pile_set_name": "PubMed Abstracts"
} |
A case-control study of lung cancer in nonsmoking women.
A case-control study of Japanese women in Nagoya was conducted to investigate the significance of passive smoking and other factors in relation to the etiology of female lung cancer. A total of 90 nonsmoking patients with primary lung cancer and their age- and ho... | {
"pile_set_name": "PubMed Abstracts"
} |
Fabrication of a hybrid PDMS/SU-8/quartz microfluidic chip for enhancing UV absorption whole-channel imaging detection sensitivity and application for isoelectric focusing of proteins.
A poly(dimethylsiloxane)(PDMS)/SU-8/quartz hybrid chip was developed and applied in the isoelectric focusing (IEF) of proteins with ult... | {
"pile_set_name": "PubMed Abstracts"
} |
Sports for the physically disabled. The 1976 Olympiad (Toronto).
The 1976 Olympiad for the Physically Disabled was the first olympiad with full competition for blind, paralyzed, and amputee athletes. More than 1,500 from 38 countries took part in wheelchair (12 events), blind (8 events), and amputee (11 events) games. ... | {
"pile_set_name": "PubMed Abstracts"
} |
A comparison of the bactericidal activity of 'Phoraid 6000' and 'Clearsol' disinfectants.
The bactericidal activity of 'Phoraid 6000' and 'Clearsol' disinfectants was evaluated using suspension and surface tests. In suspension tests, 2% 'Phoraid' achieved a > 5 log10 reduction of Pseudomonas aeruginosa, Escherichia col... | {
"pile_set_name": "PubMed Abstracts"
} |
Development of a low-budget tobacco prevention media campaign.
Utah joined the ranks of other states that have passed a tobacco tax to fund a tobacco control program, including a media campaign. However, unlike other states working with multimillion dollar campaigns, $250,000 was allocated toward an anti-tobacco media ... | {
"pile_set_name": "PubMed Abstracts"
} |
Efficient catalytic conversion of concentrated cellulose feeds to hexitols with heteropoly acids and Ru on carbon.
A combination of heteropolyacids and Ru on carbon catalyzes the conversion of concentrated cellulose feeds into hexitols under H(2) pressure. Quantitative conversion of ball-milled cellulose was observed w... | {
"pile_set_name": "PubMed Abstracts"
} |
Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats.
Life-long food restriction is known to slow aging and reduce the rate of occurrence of age-associated disease processes, but the mechanism by which this is accomplished is unknown. In this study we have examin... | {
"pile_set_name": "PubMed Abstracts"
} |
Differential mechanism of peptide YY and neuropeptide Y in inhibiting motility of guinea-pig colon.
The effect of peptide YY on contractility, acetylcholine release and noradrenaline release was examined in the isolated guinea-pig colon, and findings were compared with those for neuropeptide Y. Peptide YY and neuropept... | {
"pile_set_name": "PubMed Abstracts"
} |
Pathological and therapeutic roles of innate lymphoid cells in diverse diseases.
Innate lymphoid cells (ILCs) are a recently defined type of innate-immunity cells that belong to the lymphoid lineage and have lymphoid morphology but do not express an antigen-specific B cell or T-cell receptor. ILCs regulate immune funct... | {
"pile_set_name": "PubMed Abstracts"
} |
Spatio-temporal cortical source imaging of brain electrical activity by means of time-varying parametric projection filter.
In the present study, we explore suitable spatio-temporal filters for inverse estimation of an equivalent dipole-layer distribution from the scalp electroencephalogram (EEG) for imaging of brain e... | {
"pile_set_name": "PubMed Abstracts"
} |
Human gut microbiota and its relationship to health and disease.
Probiotics are live microorganisms that confer a health benefit on the host when administered in appropriate amounts. Over 700 randomized, controlled, human studies have been conducted with probiotics thus far, with the results providing strong support fo... | {
"pile_set_name": "PubMed Abstracts"
} |
Factors associated with the specific worries of childhood cancer survivors: Cross-sectional survey in Japan.
Previous research has shown that adult childhood cancer survivors (CCS) have many worries. We re-analyzed the employment data in order to identify these worries and their associated factors. The participants wer... | {
"pile_set_name": "PubMed Abstracts"
} |
Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya.
Relationships between Plasmodium falciparum incidence and entomologic inoculation rates (EIRs) were determined for a 21-month period in Saradidi, western Kenya, in preparation for ... | {
"pile_set_name": "PubMed Abstracts"
} |
Thallium isotopic evidence for ferromanganese sediments in the mantle source of Hawaiian basalts.
Ocean island basalts are generally thought to be the surface expression of mantle plumes, but the nature of the components in the source regions of such mantle plumes is a subject of long-standing debate. The lavas erupted... | {
"pile_set_name": "PubMed Abstracts"
} |
Pre-steady-state kinetic analysis of 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase: kinetic evidence for enol/keto tautomerization.
The reaction catalyzed by 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase (MhpC) was analyzed by stopped-flow UV-visible kinetics at 317 nm (substrate depletion... | {
"pile_set_name": "PubMed Abstracts"
} |
[Value of serum miR-155-5p and miR-133a-3p expression for the diagnosis and prognosis evaluation of sepsis].
To explore the value of serum microRNA-155-5p and -133a-3p (miR-155-5p and miR-133a-3p) expression for the diagnosis and prognosis evaluation of sepsis. A prospective observational study was conducted. 105 sepsi... | {
"pile_set_name": "PubMed Abstracts"
} |
Further understanding of the immunopathology of multiple sclerosis: impact on future treatments.
The understanding of the immunopathogenesis of multiple sclerosis (MS) has expanded with more research into T-cell subtypes, cytokine contributors, B-cell participation, mitochondrial dysfunction, and more. Treatment option... | {
"pile_set_name": "PubMed Abstracts"
} |
Plasmon hybridization in nanoshell dimers.
We extend the plasmon hybridization method to investigate the plasmon modes of metallic nanoshell dimers. The formalism is also generalized to include the effects of dielectric backgrounds. It is shown that the presence of dielectrics shifts the plasmon resonances of the indiv... | {
"pile_set_name": "PubMed Abstracts"
} |
Current and emerging pharmaceutical interventions for myopia.
Myopia is a major cause of visual impairment. Its prevalence is growing steadily, especially in East Asia. Despite the immense disease and economic burden, there are currently no Food and Drug Administration-approved drugs for myopia. This review aims to sum... | {
"pile_set_name": "PubMed Abstracts"
} |
Cytokines hold promise for human embryo culture in vitro: results of a randomized clinical trial.
To evaluate the effects of cytokine enrichment of culture medium on embryological and clinical outcomes after intracytoplasmic sperm injection (ICSI). A randomized clinical trial. In vitro fertilization centers. This trial... | {
"pile_set_name": "PubMed Abstracts"
} |
Resistance to acute nephrotoxicity induced by cadmium-metallothionein dependence on pretreatment with cadmium chloride.
Three groups of rats (B-D) were given various daily doses of CdCl2 (0.5-2 mg Cd/kg) continuously or in intervals during time periods of 1-8 weeks. Another group of animals (A) were kept untreated. At ... | {
"pile_set_name": "PubMed Abstracts"
} |
Effects of PEG-lipids on permeability of phosphatidylcholine/cholesterol liposomes in buffer and in human serum.
The permeability of liposomal membranes was studied as a function of the amount of incorporated PEG-lipid. The fluorescent dyes ethidium, propidium and 5(6)-carboxy fluorescein were used as markers for measu... | {
"pile_set_name": "PubMed Abstracts"
} |
Expression of cyanobacterial genes involved in heterocyst differentiation and dinitrogen fixation along a plant symbiosis development profile.
Members of the cyanobiont genus Nostoc, forming an endosymbiosis with members of the angiosperm genus Gunnera, undergo a number of characteristic phenotypic changes during the d... | {
"pile_set_name": "PubMed Abstracts"
} |
Concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: is intergroup study 0099 feasible in Japanese patients?
Since the publication of the significant results of the Intergroup Study 0099 (IGS) in 1998, radical radiation therapy (RT) with concurrent and adjuvant chemotherapy has become the ... | {
"pile_set_name": "PubMed Abstracts"
} |
Suprapontine control of respiration.
Despite focus on brainstem areas in central respiratory control, regions rostral to the medulla and pons are now recognized as being important in modulating respiratory outflow during various physiological states. The focus of this review is to highlight the role that suprapontine a... | {
"pile_set_name": "PubMed Abstracts"
} |
BMP-2 gene activated muscle tissue fragments for osteochondral defect regeneration in the rabbit knee.
Previously published data indicate that BMP-2 gene activated muscle tissue grafts can repair large bone defects in rats. This innovative abbreviated ex vivo gene therapy is appealing because it does not require elabor... | {
"pile_set_name": "PubMed Abstracts"
} |
Theory of mind and prosocial behavior in childhood: A meta-analytic review.
It has been argued that children who possess an advanced theory of mind (ToM) are more likely to act prosocially, yet the empirical findings are mixed. To address this issue definitively, a meta-analytic integration of all prior literature that... | {
"pile_set_name": "PubMed Abstracts"
} |
Peripheral muscle weakness and exercise capacity in children with cystic fibrosis.
Exercise intolerance in cystic fibrosis (CF) is attributed to diminished nutritional and pulmonary function. We studied the pathophysiology of such intolerance in relation to muscle force and fat-free mass (FFM), in 15 children with mode... | {
"pile_set_name": "PubMed Abstracts"
} |
Renal siderosis in donor allograft: pathologic and clinical sequelae.
Transplantation of a cadaver kidney with marked siderosis and its outcome has not been reported. Increasing use of marginal kidneys has become common practice to expand the donor pool to meet the growing demand and will lead to increased recognition ... | {
"pile_set_name": "PubMed Abstracts"
} |
Outpatient conversion of treatment to potassium-sparing diuretics.
Thiazide diuretics frequently cause a decrease in serum potassium levels. In this study, 34 percent of patients taking hydrochlorothiazide had serum potassium levels below 3.5 meq/liter. The response of the serum potassium level was studied after treatm... | {
"pile_set_name": "PubMed Abstracts"
} |
[Prevalence of hepatitis C virus antibodies in a hemodialysis unit].
The prevalence of hepatitis C antibody was studied using the EIA 2 Abbott assay in patients and staff of the San Juan de Dios Hospital Hemodialysis Unit. The antibody was detected in 29.8% of patients, no member of the staff had positive antibodies. P... | {
"pile_set_name": "PubMed Abstracts"
} |
Phenolic compounds in wheat grain cultivars.
Three hydroxybenzoic acids: p-hydroxybenzoic acid, vanillic acid and syringic acid; six hydroxycinnamic acids: p-coumaric acid, ferulic acid and four ferulic acid derivatives and a flavonoid (apigenin) were identified and quantified in 34 accessions corresponding to 19 culti... | {
"pile_set_name": "PubMed Abstracts"
} |
Distribution of polyamines may be altered in different scalp regions of patients with hair loss.
Hair loss, from the vertex or front of the head, generally occurs due to increased androgenic steroid levels. Androgenic steroids, particularly testosterone and dihydrotestosterone, are distributed differently across the ve... | {
"pile_set_name": "PubMed Abstracts"
} |
Effect of cyclic cisplatin and etoposide therapy with continuous UFT administration on the recurrence of endometrial cancer in nude mice.
Effects of cisplatin and etoposide chemotherapy and/or continuous administration of oral anticancer agent UFT following the initial chemotherapy with cisplatin and etoposide on the t... | {
"pile_set_name": "PubMed Abstracts"
} |
Intention to quit smoking: is the partner's smoking status associated with the smoker's intention to quit?
Smoking behavior among couples is often similar. The aim of the study was to examine the relationship between the partner's smoking status and the intention to stop smoking of the index person. Cross-sectional dat... | {
"pile_set_name": "PubMed Abstracts"
} |
Reduced parathyroid hormone response to peroral phosphate in osteoporotic patients.
To determine whether PTH secretion can be stimulated in osteoporosis by peroral phosphate (1.5 g phosphorus), we have compared serum PTH and urinary cyclic AMP responses in 8 osteoporotic patients with vertebral compression fractures to... | {
"pile_set_name": "PubMed Abstracts"
} |
Ki-67 and the Chromosome Periphery Compartment in Mitosis.
The chromosome periphery is a complex network of proteins and RNA molecules (many derived from nucleoli) that covers the outer surface of chromosomes and whose function remains mysterious. Although it was first described over 130 years ago, technological advanc... | {
"pile_set_name": "PubMed Abstracts"
} |
[Analysis of the reasons for the late detection of malignant tumors (based on data from the Voroshilovgrad Province Oncological Dispensary)].
The share of advanced malignant tumors is approximately 22.9%, the highest incidence rate (57.1%) being among patients aged 51--70 years. They show the following distribution for... | {
"pile_set_name": "PubMed Abstracts"
} |
Accuracy of Four Imaging Techniques for Diagnosis of Posterior Pelvic Floor Disorders.
To establish the diagnostic test accuracy of evacuation proctography, magnetic resonance imaging (MRI), transperineal ultrasonography, and endovaginal ultrasonography for detecting posterior pelvic floor disorders (rectocele, enteroc... | {
"pile_set_name": "PubMed Abstracts"
} |
[Clinical variants of neuropsychological disorders during remission in chronic alcoholism].
To study the psychopathological characteristics of remissions in alcoholism, 142 patients aged 32 to 45 years were examined. The anxious hypochondriac, neurasthenia-like, asthenic-depressive, anxious suspicious, anxious depressi... | {
"pile_set_name": "PubMed Abstracts"
} |
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