text
stringlengths
1
6.74k
meta
dict
Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells. scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p5...
{ "pile_set_name": "PubMed Abstracts" }
Micellar crystallization with a hysteresis in temperature. We have investigated the phase diagram of the triblock copolymer P123 solved in water by viscosity measurements for different concentrations and temperatures. The structures of the different phases were identified by surface sensitive neutron diffraction. We fi...
{ "pile_set_name": "PubMed Abstracts" }
In vivo detection of mutations induced by aflatoxin B1 using human CYP3A7/HITEC hybrid mice. CYP3A7-M10 mouse is a transgenic mouse carrying human CYP3A7 cDNA, in which CYP3A7 is expressed in the small intestine but not in the kidney. HITEC mouse is a transgenic mouse developed to detect mutagenic potency of various ch...
{ "pile_set_name": "PubMed Abstracts" }
Peering into the literature: A systematic review of the roles of people who inject drugs in harm reduction initiatives. People who inject drugs have been central to the development of harm reduction initiatives. Referred to as peer workers, peer helpers, or natural helpers, people with lived experience of drug use leve...
{ "pile_set_name": "PubMed Abstracts" }
Craniofacial fibrous dysplasia and Ollier's disease: combined transfrontal and transfacial resection using the nasal-cheek flap. Fibrous dysplasia and Ollier's disease (skeletal chondromatosis) are bone lesions that result from disorders occurring during ossification. Here we report on a patient suffering from Ollier's...
{ "pile_set_name": "PubMed Abstracts" }
Mechanisms and Evidence for Heart Failure Benefits from SGLT2 Inhibitors. To review the clinical trial data and underlying mechanistic principles in support of the robust cardiovascular (CV) benefits, in particular, heart failure (HF) outcomes association with sodium-glucose co-transporter-2 (SGLT2) inhibitors. Several...
{ "pile_set_name": "PubMed Abstracts" }
Treatment of a patient with severe hemorrhagic fever accompanied by infection with methicillinresistant Staphylococcus aureus, Acinetobacter baumannii, aspergillus and mucor: a case report. A 40-year-old Korean man developed hemorrhagic fever in Xi'an, which is one of the main endemic areas for this illness in China. A...
{ "pile_set_name": "PubMed Abstracts" }
The value of early SPECT/CT and hand-held γ-camera in radio-guided surgery: a case of a hard-to-locate parathyroid adenoma. A patient with primary hyperparathyroidism underwent radio-guided surgery by means of a γ-probe and a hand-held γ-camera. Before surgery, a parathyroid double-phase planar scintigraphy and an earl...
{ "pile_set_name": "PubMed Abstracts" }
Physicians perception of health insurance in Saudi Arabia. To assess physicians views on health insurance and its implication on the health care system. We carried out a cross-sectional study in 2 major hospitals in Riyadh, Kingdom of Saudi Arabia. Data were collected from January to December 2002 through self-administ...
{ "pile_set_name": "PubMed Abstracts" }
Do interspecies correlation estimations increase the reliability of toxicity estimates for wildlife? For warm-blooded species, the hazardous dose of a chemical (HD50) is an upcoming and important characteristic in the assessment of toxic chemicals. Generally, experimental information is available for a limited number o...
{ "pile_set_name": "PubMed Abstracts" }
The beneficial effects of Tai Chi Chuan on blood pressure and lipid profile and anxiety status in a randomized controlled trial. To evaluate the effects on blood pressure, lipid profile, and anxiety status on subjects received a 12-week Tai Chi Chuan exercise program. Randomized controlled study of a Tai Chi Chuan grou...
{ "pile_set_name": "PubMed Abstracts" }
Gender-based disparities East/West: rethinking the burden of care in the United States and Taiwan. When feminist bioethicists express concerns about health-related gender disparities, they raise considerations about justice and gender that traditional bioethicists have either not raised or raised somewhat weakly. In th...
{ "pile_set_name": "PubMed Abstracts" }
Descending thoracic aorta-splenic artery graft for occlusive disease of the celiac axis. A new procedure is presented for the restoration of normal blood flow to the celiac axis in cases of orifice lesions of the celiac artery. The operation consists of inserting a graft between the descending thoracic aorta end-to-sid...
{ "pile_set_name": "PubMed Abstracts" }
Semi-empirical model for depth dose distributions of megavoltage x-ray beams. The dose distribution due to absorption of photon energy fluence in a homogeneous water phantom irradiated by megavoltage x-ray beams has been analyzed with a semiempirical model. The method generalizes an analytical formalism for the scatter...
{ "pile_set_name": "PubMed Abstracts" }
LATS2 inhibits the activity of NF-κ B signaling by disrupting the interaction between TAK1 and IKKβ. NF-κB signaling plays very important role in the tumorigenesis of nonsmall cell lung cancer (NSCLC). However, the molecular mechanisms for the dysregulation of NF-κB signaling in NSCLC have not been fully understood. In...
{ "pile_set_name": "PubMed Abstracts" }
Progress toward the total synthesis of bacchopetiolone: application of a tandem aromatic oxidation/Diels-Alder reaction. A stereoselective synthesis of the bacchopetiolone (1) carbocyclic core using a tandem phenolic oxidation/Diels-Alder reaction is described. [reaction: see text].
{ "pile_set_name": "PubMed Abstracts" }
An analysis of consanguineous marriage in the Muslim population of India at regional and state levels. Consanguineous marriage is widely favoured in a large majority of the world's Islamic populations. According to recent estimates, the resident Muslim population of India is over 100 million. However, apart from a few ...
{ "pile_set_name": "PubMed Abstracts" }
[The effect of thalamic stimulation on levodopa induced dyskinesias--evaluation of a new target: the center parafascicular median]. After 10 years of clinical practice (1987-1997), chronic thalamic deep brain stimulation (DBS) is considered to be effective in the treatment of drug-resistant parkinsonian tremor. DBS has...
{ "pile_set_name": "PubMed Abstracts" }
A pilot study of time allocation and reimbursement for routine obstetric ultrasonography. To evaluate time allocation during initial and repeated ultrasonography and to formulate recommendations to improve unit efficiency. Over a 2-year period, 51 comprehensive ultrasonographic examinations between 14 and 38 weeks' ges...
{ "pile_set_name": "PubMed Abstracts" }
Biodegradable cellulose acetate nanofiber fabrication via electrospinning. Nanofiber manufacturing is one of the key advancements in nanotechnology today. Over the past few years, there has been a tremendous growth of research activities to explore electrospinning for nanofiber formation from a rich variety of material...
{ "pile_set_name": "PubMed Abstracts" }
The cDNA sequence of murine Nkx-2.2. We isolated and sequenced a 2026-bp murine Nkx-2.2 cDNA clone that contains an open reading frame encoding 273 amino acids (aa). The 273-aa protein includes a homeobox, an NK-2 box and a N-terminal decapeptide found in other Nk family members.
{ "pile_set_name": "PubMed Abstracts" }
Intracranial metastases from a supraglottic carcinoma (a case report). An extremely rare case of intracranial metastasis from a laryngeal carcinoma is reported associated with multiple pulmonary metastatic deposits.
{ "pile_set_name": "PubMed Abstracts" }
Eradication of Plant Pathogens in Forest Nursery Irrigation Water. Interest in rational use and reuse of water has increased in recent years, especially in forest nurseries. However, before water can be reused in nurseries, it must be properly treated to eradicate plant pathogens to reduce risks of pathogen dispersal a...
{ "pile_set_name": "PubMed Abstracts" }
Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the β₂-adrenergic receptor. The understanding of β₂-adrenergic receptor (β₂AR) interactions with ligands as well as the mechanism of receptor activation changed radically from 2007, when the first crystallographic stru...
{ "pile_set_name": "PubMed Abstracts" }
Evaluation of the flow characteristics of an internal thoracic artery graft after coronary artery bypass grafting by intercostal Duplex scanning ultrasonography. We previously reported intercostal duplex scanning ultrasonography to be a reliable technique for the evaluation of the internal thoracic artery (ITA). The pu...
{ "pile_set_name": "PubMed Abstracts" }
Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children. Recent studies reported that gamma-glutamyltransferase (GGT) and beta 2-microglobulin (β2M) are possible markers of cardiovascular disease in adults, however, their roles...
{ "pile_set_name": "PubMed Abstracts" }
[Tuberculosis and HIV infection in the Kweneng district, Botswana]. The prevalence of HIV infection in a group of Botswana tuberculosis patients was studied in a linked, anonymous survey that included 214 cases. The testing was done by ELISA serology. 45 of 214 patients (21%) were HIV positive. The HIV seropositivity r...
{ "pile_set_name": "PubMed Abstracts" }
Investigating the Low Temperature Formation of CuII -(N,O) Species on Cu-CHA Zeolites for the Selective Catalytic Reduction of NOx. In this work, we show the potentiality of operando FTIR spectroscopy to follow the formation of CuII -(N,O) species on Cu exchanged chabazite zeolites (Cu-CHA), active for the selective ca...
{ "pile_set_name": "PubMed Abstracts" }
Validation of Heine Gamma G7 (G5) and XXL-LF aneroid devices for blood pressure measurement. To determine the accuracy of the Gamma G7 (and G5 model) and XXL-LF aneroid sphygmomanometers developed by the Heine Company. Device evaluations were performed using the new protocol of the European Society of Hypertension. Mon...
{ "pile_set_name": "PubMed Abstracts" }
[Twin transfusion syndrome--diagnosis and prognosis]. Twin-twin transfusion syndrome is a serious complication of monozygotic, monochorionic, diamniotic twins resulting from transplacental vascular communications. In this syndrome blood is thought to be shunted from one twin--donor, who develops anaemia, growth retarda...
{ "pile_set_name": "PubMed Abstracts" }
Two polymorphic dinucleotide repeats in intron 44 of the dystrophin gene. Duchenne muscular dystrophy (DMD) is one of the most common and severe X-linked disorders with an incidence of approximately 1 in 3500 newborn males. In more than 60% of DMD patients, deletions of part or all of the dystrophin gene have been show...
{ "pile_set_name": "PubMed Abstracts" }
Emphysema-like changes in the lungs of the blotchy mouse. The Blotchy allele is one of several mutations at the Mottled locus on the mouse X-chromosome. Affected males and heterozygous females within the several allelic groups possess varying degrees of connective tissue abnormalities similar to those found in copper-d...
{ "pile_set_name": "PubMed Abstracts" }
Enhanced degradation of naphthalene by immobilization of Pseudomonas sp. strain NGK1 in polyurethane foam. A Pseudomonas sp. strain NGKI (NCIM 5120) capable of degrading naphthalene was immobilized in polyurethane foam. The naphthalene-degrading activity of the freely suspended cells was compared with that of immobiliz...
{ "pile_set_name": "PubMed Abstracts" }
Protection of nigral cell death by bilateral subthalamic nucleus stimulation. In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic...
{ "pile_set_name": "PubMed Abstracts" }
Clinical impact of sentinel lymph node biopsy in patients with thick (>4 mm) melanomas. The role of sentinel lymph node status (SLNS) in thick melanoma is evolving. The purpose of this study was to determine the prognostic value of SLNS in thick melanoma. A retrospective analysis of 120 prospectively collected clinical...
{ "pile_set_name": "PubMed Abstracts" }
[Human diseases caused by leptospirae of the canicola serogroup in the Krasnodar Territory]. During the period of 34 years (1957-1990) diseases caused by leptospires of the serogroup canicola were confirmed in 2.7% of the total number of patients. The analysis revealed that in the presence of epidemic outbreaks Leptosp...
{ "pile_set_name": "PubMed Abstracts" }
Gamma delta T-cells in human cutaneous immunology. Gamma delta T-Cells represent a minor subpopulation of T-lymphocytes in man and their role in normal and diseased human skin is unknown. This article is a comprehensive review of T-lymphocytes bearing the gamma delta T-cell receptor in normal and pathological human ski...
{ "pile_set_name": "PubMed Abstracts" }
Hepatitis C virus antibodies in subjects with and without liver disease in the United Kingdom. The prevalence of antibody to hepatitis C virus, evidence of previous or current infection with this agent of parenterally transmitted non-A, non-B hepatitis, was determined in 340 subjects residing in the United Kingdom. The...
{ "pile_set_name": "PubMed Abstracts" }
Efficacy of Contrast-enhanced Computed Tomography for the Treatment Strategy of Colonic Diverticular Bleeding. Diverticular bleeding is the most common cause of acute lower gastrointestinal bleeding, and its incidence has recently increased. However, the treatment strategy of diverticular bleeding has not yet been esta...
{ "pile_set_name": "PubMed Abstracts" }
Diagnosis support system based on clinical guidelines: comparison between case-based fuzzy cognitive maps and Bayesian networks. Several studies have described the prevalence and severity of diagnostic errors. Diagnostic errors can arise from cognitive, training, educational and other issues. Examples of cognitive issu...
{ "pile_set_name": "PubMed Abstracts" }
Prevalence of the 35delG mutation in the GJB2 gene in two samples of non-syndromic deaf subjects from Chile. Hearing loss is the most common inherited sensorial deficiency in humans; about 1 in 1000 children suffer from severe or profound hearing loss at birth. Mutations in the GJB2 gene are the most common cause of pr...
{ "pile_set_name": "PubMed Abstracts" }
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances. 5-HT4 and 5-HT6 serotonergic receptors are located in brain structures involved in memory processes. Neurochemical and behavioural studies have demonstrated that acute activation of 5-HT4 receptors (5-HT4R) or blockade of ...
{ "pile_set_name": "PubMed Abstracts" }
How to identify suitable ways for the hydrothermal treatment of wet bio-waste? A critical review and methods proposal. A considerable amount of wet biogenic residues and waste has no resource-efficient use in several European countries yet. Hydrothermal processes (HTP) seem to be promising for treating such biomass as ...
{ "pile_set_name": "PubMed Abstracts" }
Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay. To determine the major dietary patterns associated with bladder cancer risk, we conducted a principal components analysis (PCA) in a case-control study from Uruguay. A total of 255 newly diagnosed and microscopically confirmed cases of transitio...
{ "pile_set_name": "PubMed Abstracts" }
[The non-invasive accessible informative laboratory panel for detection of liver fibrosis - TEA index.] The article presents the results of continued studies of informative accessible tests as a screening non-invasive technique of diagnostic of fibrosis under chronic hepatitis C. The sampling included 70 patients with ...
{ "pile_set_name": "PubMed Abstracts" }
Semantic dementia: aspects of the early diagnosis. Semantic dementia is a lobar atrophy syndrome, related to a degeneration of anterior temporal regions, and characterized by a very predominant impairment of semantic memory. Whereas the diagnosis is relatively easy to establish in the typical form and if the patient is...
{ "pile_set_name": "PubMed Abstracts" }
Object relations issues in the treatment of the preoedipal character. It was through tolerance of Ms. D.'s infantile rage (i.e., rage against reality and its limits) that the analyst was able to open up a dialogue with the patient that could lead to a developmental mourning process. The same was true for the borderline...
{ "pile_set_name": "PubMed Abstracts" }
A cluster algorithm for Monte Carlo simulation at constant pressure. We propose an efficient algorithm to sample the volume in Monte Carlo simulations in the isobaric-isothermal ensemble. The method is designed to be applied in the simulation of hard-core models at high density. The algorithm is based in the generation...
{ "pile_set_name": "PubMed Abstracts" }
Clinical score system in the treatment of Cushing's disease: failure to identify discriminative variables from the German Cushing's Registry. To develop a multidimensional and integrated clinical scoring instrument, that encompasses, summarizes and weights appropriately the desired clinical benefits of a treatment for ...
{ "pile_set_name": "PubMed Abstracts" }
Endoscopic stapling for pharyngeal pouch: does it make the cut? Endoscopic stapling to treat pharyngeal pouch is a relatively new technique with the potential to reduce the morbidity associated with the open approach for pharyngeal pouch. Despite enthusiasm for the endoscopic approach there have been no series reported...
{ "pile_set_name": "PubMed Abstracts" }
Nitric oxide inhibits smooth muscle responses evoked by cholinergic nerve stimulation in the guinea pig gastric fundus. In circular smooth muscle tissues of the guinea pig gastric fundus, transmural nerve stimulation (TNS) evoked an atropine-sensitive cholinergic excitatory junction potential (e.j.p.) and, after inhibi...
{ "pile_set_name": "PubMed Abstracts" }
Prognostic impact of clopidogrel pretreatment in patients with acute coronary syndrome managed invasively. Pretreatment with antiP2Y12 agents before angiography in acute coronary syndrome (ACS) is associated with a reduction in thrombotic events. However, recent evidences have questioned the benefits of upstream antiP2...
{ "pile_set_name": "PubMed Abstracts" }
Pharmacological actions of a new TRH analogue, YM-14673, in rats subjected to cerebral ischemia and anoxia. The cerebral protective actions of a new thyrotropin releasing hormone (TRH) analogue, YM-14673, [Na-[[(S)-4-oxo-2-azetidinyl-carbonyl]-L-histidyl-L-prolinamide] dihydrate), were compared with those of CDP-cholin...
{ "pile_set_name": "PubMed Abstracts" }
Robust Distance Metric Learning via Bayesian Inference. Distance metric learning (DML) has achieved great success in many computer vision tasks. However, most existing DML algorithms are based on point estimation, and thus are sensitive to the choice of training examples and tend to be over-fitting in the presence of l...
{ "pile_set_name": "PubMed Abstracts" }
Primary aortoenteric fistula and endovascular repair. Primary aortoenteric fistulae are difficult conditions to diagnose and manage. A 35-year-old male developed massive upper gastrointestinal hemorrhage due to a primary aortoduodenal fistula. Previous radiation therapy and retroperitoneal lymph node dissection for ger...
{ "pile_set_name": "PubMed Abstracts" }
In vitro and in vivo responses of saccular and caudal nucleus neurons in the grassfrog (Rana temporaria). We present results from in vitro and in vivo studies of response properties of neurons in the saccular and caudal nuclei in the frog. In the in vitro studies the saccular nerve of the isolated brain was stimulated ...
{ "pile_set_name": "PubMed Abstracts" }
[Initial X-ray manifestations of bronchial carcinoma. Possibilities and limitations of early diagnosis (author's transl)]. Problems of defining "early diagnosis" and difficulties, arising from multiform clinical and radiological manifestations in bronchial carcinoma are discussed. Different types of manifestations offe...
{ "pile_set_name": "PubMed Abstracts" }
The dietary inflammatory index is associated with gastrointestinal infection symptoms in the national health and nutrition examination survey. Inflammation influences many aspects of health including gastrointestinal illnesses. Associations between the Dietary Inflammatory Index (DII®) and gastrointestinal symptoms wer...
{ "pile_set_name": "PubMed Abstracts" }
Isolation and preliminary characterisation of two toxic phospholipases A2 from the venom of the Malayan cobra (Naja naja sputatrix). Two toxic phospholipases A have been isolated from the venom of the Malayan cobra (Naja naja sputatrix). The phospholipases A were purified by successive ion-exchange chromatography on SP...
{ "pile_set_name": "PubMed Abstracts" }
Coupled-mode-theory framework for nonlinear resonators comprising graphene. A general framework combining perturbation theory and coupled-mode theory is developed for analyzing nonlinear resonant structures comprising dispersive bulk and sheet materials. To allow for conductive sheet materials, a nonlinear current term...
{ "pile_set_name": "PubMed Abstracts" }
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Fungal diseases still play a major role in morbidity and mortality in patients with haematological malignancies, including those undergoing haema...
{ "pile_set_name": "PubMed Abstracts" }
Prevention of postherpetic neuralgia with varicella-zoster hyperimmune globulin. Recovery after an acute attack of herpes zoster is followed by postherpetic neuralgia (PHN) in 9-14% of all patients. Depending on the patient's age, the severity of the acute attack of herpes zoster and the dermatome involved, the inciden...
{ "pile_set_name": "PubMed Abstracts" }
Chromosomal assignment of human VIP/PHM-27 gene to 6q26----q27 region by spot blot hybridization and in situ hybridization. We determined the chromosomal location of the human VIP/PHM-27 gene in two different ways. First, we performed chromosome sorting with a cell sorter. Sufficient numbers of chromosomes for sorting ...
{ "pile_set_name": "PubMed Abstracts" }
Molecular phylogeny of monogeneans parasitizing African freshwater Cichlidae inferred from LSU rDNA sequences. The African freshwater fish of Cichlidae are parasitized by five genera of monogeneans belonging to Dactylogyridea. Ectoparasitic Scutogyrus, Onchobdella, and the highly diversified Cichlidogyrus represent thr...
{ "pile_set_name": "PubMed Abstracts" }
Credentialing of certified registered nurse anesthetists. Certified registered nurse anesthetists (CRNAs) have provided anesthesia services in this country since the mid-1800s. As the earliest advanced practice nurse specialists, CRNAs have been leaders in the development of educational programs, accreditation, certifi...
{ "pile_set_name": "PubMed Abstracts" }
Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease. Adenosine to inosine (A-to-I) RNA editing is a base recoding process within precursor messenger RNA, catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family. A notable example occurs at the Q/R site of the α-amino-3-hydr...
{ "pile_set_name": "PubMed Abstracts" }
Recognition latency for pictures and words as a function of encoded-feature similarity. In separate trials of a same-different recognition task, a single target item presented as either a picture or a word was followed after a 30-sec delay by a single test item, either a picture or a word. Test items were either nomina...
{ "pile_set_name": "PubMed Abstracts" }
The Pacific Identity and Wellbeing Scale-Revised (PIWBS-R). We develop and validate a revised version of the Pacific Identity and Wellbeing Scale (the PIWBS-R). This revision extends the original 5-factor PIWBS model to include a sixth subscale assessing Cultural Efficacy (CE). The definition and item content for CE wa...
{ "pile_set_name": "PubMed Abstracts" }
Quantification of organellar DNA and RNA using real-time PCR. Quantitative (real-time) polymerase chain reaction (PCR) allows the measurement of relative organellar gene copy numbers as well as transcript abundance of individual mitochondrial or plastidial genes. Requiring only minute amounts of total DNA or RNA, the d...
{ "pile_set_name": "PubMed Abstracts" }
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas. The effects of CRH and somatostatin (SRIH) on adenylate cyclase (AC) activity, intracellular free calcium concentrations [( Ca2+]i)...
{ "pile_set_name": "PubMed Abstracts" }
Tissue-specific expression of human terminal deoxynucleotidyl transferase is regulated at the transcriptional level. Transcriptional regulation of expression of the terminal deoxynucleotidyl transferase gene in normal thymus and in differentiation arrested cells was demonstrated by analyzing steady-state levels of TdT ...
{ "pile_set_name": "PubMed Abstracts" }
[Expression of tyrosine kinase receptor B in human follicle]. To study the expression of tyrosine kinase receptor B(TrkB) in human follicle and explore the significance of the expression. Streptavidin-biotin peroxidase complex immunocytochemistry was employed to determine the expression of TrkB on the oocytes, cumulus ...
{ "pile_set_name": "PubMed Abstracts" }
Voxel-based morphometry reveals excess gray matter concentration in patients with focal cortical dysplasia. Many patients with focal cortical dysplasia (FCD) continue to have seizures after surgical treatment. The usual explanation for the poor surgical outcome is the presence of residual dysplastic tissue missed by th...
{ "pile_set_name": "PubMed Abstracts" }
Inverse metabolic engineering with phosphagen kinase systems improves the cellular energy state. Inverse metabolic engineering attempts to identify or construct desired phenotypes of applied interest to endow them on appropriate host organisms. A particular desirable phenotype is the ATP homeostasis exhibited by animal...
{ "pile_set_name": "PubMed Abstracts" }
[Effects of nicotine and cannabinoids on the central nervous system]. We describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. Like other drugs of abuse, these compounds enhance dopamine release in a precise area of the limbic system when admini...
{ "pile_set_name": "PubMed Abstracts" }
Primary charge separation routes in the BChl:BPhe heterodimer reaction centers of Rhodobacter sphaeroides. Energy transfer and the primary charge separation process are studied as a function of excitation wavelength in membrane-bound reaction centers of Rhodobacter sphaeroides in which the excitonically coupled bacteri...
{ "pile_set_name": "PubMed Abstracts" }
In vivo evaluation of poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin as an in situ-formable scaffold. We examined whether poly(N-isopropylacrylamide)-grafted gelatin (PNIPAM-gelatin) with a lower critical solution temperature of approximately 34 degrees C, which was prepared by quasi-living radical graft polymeri...
{ "pile_set_name": "PubMed Abstracts" }
Clinical utility of 4D FDG-PET/CT scans in radiation treatment planning. The potential role of four-dimensional (4D) positron emission tomography (PET)/computed tomography (CT) in radiation treatment planning, relative to standard three-dimensional (3D) PET/CT, was examined. Ten patients with non-small-cell lung cancer...
{ "pile_set_name": "PubMed Abstracts" }
Human health risk assessment of occupational and residential exposures to dechlorane plus in the manufacturing facility area in China and comparison with e-waste recycling site. A screening level human health risk assessment based on the worst-case scenario was conducted on the occupational and residential exposures to...
{ "pile_set_name": "PubMed Abstracts" }
Porphyria cutanea tarda and systemic lupus erythematosus. Fifty-five patients with porphyria cutanea tarda (PCT) were examined for the simultaneous occurrence of systemic lupus erythematosus (SLE). The diagnostic criteria for SLE were those set up by the American Rheumatism Association (ARA). No patient fulfilled the A...
{ "pile_set_name": "PubMed Abstracts" }
Imaging centrosomes and cilia in the mouse kidney. The centrosome and cilium are evolutionarily conserved components of the microtubule cytoskeleton, and act as a cellular signaling center that regulates the activity of numerous developmental signaling pathways. Several genetic syndromes, called the ciliopathies, are a...
{ "pile_set_name": "PubMed Abstracts" }
Crossover enhancements in GEFREX. This letter describes some improvements to the crossover operator in the genetic-neuro-fuzzy algorithm called genetic fuzzy rule extractor (GEFREX). Although, the new crossovers studied are very simple the performance of GEFREX, in terms of learning time, is decidedly improved.
{ "pile_set_name": "PubMed Abstracts" }
High plasma levels of a ouabain-like factor in normal pregnancy and in pre-eclampsia. Recent reports have described high levels of one or more substances which cross-react with digoxin antibodies in the serum of women with pre-eclampsia. We measured plasma ouabain-like activity and intraerythrocyte sodium and potassium...
{ "pile_set_name": "PubMed Abstracts" }
Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin. Uremic toxins are compounds normally excreted in urine that accumulate in patients with chronic kidney disease as a result of decreased renal clearance. Phenylacetic acid (PAA) has been identified as a new protein boun...
{ "pile_set_name": "PubMed Abstracts" }
Photosensitized NADH formation system with multilayer TiO2 film. A TiO(2)/polymer film on a quartz plate fabricated by a layer-by-layer method was employed for NADH production from NAD(+) with lipoamide dehydrogenase and methyl viologen in Tris-HCl buffer on irradiation with UV light, and the ultra thin film prevented ...
{ "pile_set_name": "PubMed Abstracts" }
Characterization and cyclic AMP-dependence of a hyperpolarization-activated chloride conductance in Leydig cells from mature rat testis. We recently described a cyclic AMP-activated current in the membrane of Leydig cells from mature rat testis by using the whole-cell configuration of the patch-clamp technique (Noulin ...
{ "pile_set_name": "PubMed Abstracts" }
Dominant coloboma-microphthalmos syndrome associated with sensorineural hearing loss, hematuria, and cleft lip/palate. Ocular colobomas and microphthalmos, isolated or as part of a syndrome, are usually sporadic and only rarely found in large families. A 4-generation family with autosomal dominant uveal coloboma and mi...
{ "pile_set_name": "PubMed Abstracts" }
Correlation between protein stability cores and protein folding kinetics: a case study on Pseudomonas aeruginosa apo-azurin. This paper reports a combined computational and experimental study of the correlation between protein stability cores and folding kinetics. An empirical potential function was developed, and it w...
{ "pile_set_name": "PubMed Abstracts" }
[Total expansion of the orbit for micro-orbitism]. Micro-orbitism which follows the very early arrested development of the optic vesicles hinders the fitting of a prosthesis. A total enlargement of the orbit is proposed which restores the normal dimensions and enables facial symmetry to be re-established. The risks and...
{ "pile_set_name": "PubMed Abstracts" }
Carcinosarcoma de novo of the parotid gland: case report. Salivary gland carcinosarcoma is a rare and aggressive malignant mixed tumor in which carcinomatous and sarcomatous elements coexist and metastasize together. The tumor may occur in the background of a preexisting pleomorphic adenoma or may arise de novo. We rep...
{ "pile_set_name": "PubMed Abstracts" }
Making progress against cancer in Europe in 2008. Europe is facing a cancer epidemic, with rapidly increasing incidence rates. Population growth and ageing will further increase the annual number of new patients with cancer. Cancer is a huge and growing contributor to the burden of disease and premature death within th...
{ "pile_set_name": "PubMed Abstracts" }
Radiotelemetric analysis of the effects of prevailing wind direction on Mormon cricket migratory band movement. During outbreaks, flightless Mormon crickets [Anabrus simplex Haldeman (Orthoptera: Tettigoniidae)] form large mobile groups known as migratory bands. These bands can contain millions of individuals that marc...
{ "pile_set_name": "PubMed Abstracts" }
Taxonomic status of Kitasatosporia, and proposed unification with Streptomyces on the basis of phenotypic and 16S rRNA analysis and emendation of Streptomyces Waksman and Henrici 1943, 339AL. Species classified within the genus Kitasatosporia share many of the phenotypic characteristics typical of streptomycetes. By us...
{ "pile_set_name": "PubMed Abstracts" }
An ab initio molecular dynamics study of the liquid-vapor interface of an aqueous NaCl solution: inhomogeneous density, polarity, hydrogen bonds, and frequency fluctuations of interfacial molecules. We have presented a first principles simulation study of the structural and dynamical properties of a liquid-vapor interf...
{ "pile_set_name": "PubMed Abstracts" }
Albendazole treatment of human hydatid tissue. The effect of albendazole was studied in 12 patients with cystic hydatid disease (CHD) of the liver. Six patients received albendazole continuously for 6 months, while 6 patients received albendazole for 6 courses of 4 weeks with a 2 week drug-free interval between cycles....
{ "pile_set_name": "PubMed Abstracts" }
Factors influencing movement probabilities of big brown bats (Eptesicus fuscus) in buildings. We investigated movements of female big brown bats (Eptesicus fuscus) roosting in maternity colonies in buildings in Fort Collins, Colorado (USA), during the summers of 2002, 2003, and 2005. This behavior can be of public heal...
{ "pile_set_name": "PubMed Abstracts" }
[Ankle-brachial index screening for peripheral artery disease in high cardiovascular risk patients. Prospective observational study of 370 asymptomatic patients at high cardiovascular risk]. Peripheral arterial disease is a marker of systemic atherosclerosis; it is associated with a high risk of cardiovascular disease....
{ "pile_set_name": "PubMed Abstracts" }
Simulating the cellular passive transport of glucose using a time-dependent extension of Gillespie algorithm for stochastic pi-calculus. Realistic simulations of the biological systems evolution require a mathematical model of the stochasticity of the involved processes and a formalism for specifying the concurrent nat...
{ "pile_set_name": "PubMed Abstracts" }
[Serum sodium imbalance in the bedridden elderly. Part One: Realities and problem of management]. Symptoms and other abnormalities associated with serum sodium imbalance were studied in bedridden elderly and healthy elderly subjects. 1. A significantly higher number of the bedridden elderly suffered from chronic wastin...
{ "pile_set_name": "PubMed Abstracts" }
Radiologic management of haemoptysis: diagnostic and interventional bronchial arterial embolisation. Hemoptysis can be a life-threatening pulmonary emergency with high mortality, is symptomatic of an underlying severe pulmonary disease and requires immediate diagnosis and treatment. Diagnostically, bronchoscopy, conven...
{ "pile_set_name": "PubMed Abstracts" }