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Introduction
============
Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness in the elderly worldwide.[@b1-opth-8-015] Profound vision loss is most distinct in neovascular AMD, which is a late stage of the disease.[@b1-opth-8-015] Neovascular AMD is characterized by the growth o... | {
"pile_set_name": "PubMed Central"
} |
Community-acquired bacterial meningitis is a serious infectious disease with high rates of illness and death worldwide, even in the era of effective antimicrobial drugs ([@R1]). The disease is classified as a neurologic emergency; thus, immediate diagnosis and accurate treatment are vital to save the patient's life ([@... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#Sec1}
============
Now is an exciting time to be or become a diagnostician. More diagnostic tests, including portions of the medical interview and physical examination, are being studied rigorously for their accuracy, precision, and usefulness in practice,[@CR1],[@CR2] and this research is increasingly ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
CFS, also often described as myalgic encephalomyelitis, is characterized not only by severe and prolonged fatigue drastically impairing life quality, and much more attention has been paid in the past year than ever ([@B1]--[@B6]). CFS is observed even in children and adolescents ([@B7])... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Advancing universal health coverage (UHC) to improve population health is a long-term objective that many low- and middle-income countries (LMICs) have committed to. Since the release of the World Health Report 2010, entitled 'Health systems financing: the path to universal coverage' \[[@... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Protein stability is an important determinant of organismal fitness and is central to the process of enzyme design for industrial applications \[[@pcbi.1004207.ref001]--[@pcbi.1004207.ref003]\]. Most prote... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .179}
{#sp2 .180}
{#sp3 .181}
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"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
There is evidence for a systematic association of numbers and space (i.e., the mental number line), but the nature of this association is still under discussion (Fias and Fischer, [@B15]; Aiello et al., [@B2]; van Dijck et al., [@B52]).
At the behavioral level, several space-number ass... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
A five year old female child presented to the Department of Orthopaedics, BPS Government Medical College, Sonepat, Haryana, India in June 2012, with deformity of left hand since birth. The left hand had a large median cleft with an absent middle finger and flexion deformity of the index and ring finger ([Fig. 1](#F1){r... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
5--7 million people died of stroke in 2005, and there were 62 million survivors worldwide (Strong et al. [@CR41]). The majority of these are chronically disabled. Reduced maximal muscle strength is probably the best documented motor impairment after stroke (Bohannon [@CR8]; Canning et... | {
"pile_set_name": "PubMed Central"
} |
I[NTRODUCTION]{.smallcaps} {#sec1-1}
==========================
Myelolipomas are rare benign tumors, composed of adipose and hematopoietic tissue in varying proportions, a result of metaplasia of reticuloendothelial cells, most commonly located in the adrenals. The cause of this metaplasia is not well-known, but it is... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic autoimmune disease of the liver in which intrahepatic small bile ducts are selectively destroyed by inflammatory cells \[[@CR1], [@CR2]\]. The disease is progressive and eventually results i... | {
"pile_set_name": "PubMed Central"
} |
We report a case of a 62-year-old male who presented with shortness of breath after having undergone a modified McKeown esophagectomy 6 months after induction chemotherapy for cT3N1 adenocarcinoma of the distal esophagus. A chest computed tomography demonstrated a dilated gastric conduit with evidence of hiatal obstruc... | {
"pile_set_name": "PubMed Central"
} |
Epilepsy is a chronic non-communicable neurological disorder that influences people of all ages, races, and social class from all over the world. There are more than 50 million people in the world suffering from epilepsy; 80% of these people live in developing regions, and, annually, 2.4 million new cases arise.[@ref1]... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Outcome expectancies (OE) attribute value to human action: Without expectations of resultant benefit, the likelihood of health behavior decreases. People might, for example, not question whether they could wear a helmet when riding a bicycle, but whether they decide to do so greatly dep... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The superior cervical ganglion (SCG) is the center of sympathetic innervation of all head and neck organs. It provides sympathetic input to numerous key organs and structures such as the salivary glands, pineal gland, thyroid, carotid body, choroid plexus, brain and cranial muscle vas... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The aberrant expansion of unstable CAG repeats coding for polyglutamine (polyQ) tracts underlies a group of neurodegenerative diseases, including Huntington's disease (HD) and several forms of spino-cerebellar ataxia (SCA) \[[@CR1]\]. These diseases exhibit polyQ length-dependent toxi... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are available from the Harvard Dataverse (<https://dataverse.harvard.edu/dataverse/PONE-D14-56298R1>).
Introduction {#sec001}
============
Speech and music share fundamental building blocks: sounds. Despite the fact that sounds are organized in distinct representational systems for speech and music ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
There is increasing interest regarding changes in the hypothalamus-pituitary-adrenal (HPA) axis of patients with acute cerebrovascular disease. The occurrence of cerebral infarction will not only cause damage to nerve function, but also cause endocrine, metabolic, and primarily hypothal... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
The innate immune system serves as the first line of defense against invading pathogens. This time-honored system is activated in the host until specific protection by the adaptive immune system is induced... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The start of protein biosynthesis with a formylated methionine represents a distinct bacterial feature that is absent in eukaryotes \[[@B1],[@B2]\]. The ubiquitous presence in all bacterial branches including mitochondria and chloroplast indicates a very important role of this trait in central ba... | {
"pile_set_name": "PubMed Central"
} |
A new book was published in May this year, entitled "Aorto-iliac atherosclerotic surgical pathology. Treatment and complications" having as author Dr. Horaţiu Silaghi, MD, PhD, lecturer at Vth Surgery Department, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca. The author accomplished his specialization... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-13-01059}
===============
Work-family conflict has a negative impact on an employee's work and family life, as well as his/her physical and mental health and well-being \[[@B1-ijerph-13-01059],[@B2-ijerph-13-01059],[@B3-ijerph-13-01059],[@B4-ijerph-13-01059]\]. Similarly, work-family conf... | {
"pile_set_name": "PubMed Central"
} |
The use of enzymes as industrial biocatalysts is currently a solution for many problems of modern organic chemistry, which tries to carry out the most complex reactions under the rules of green chemistry \[[@B1-molecules-22-00601]\]. In this context, enzyme immobilization is a critical point for the implementation of m... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-microorganisms-06-00094}
===============
The Amargosa vole (*Microtus californicus scirpensis*) is a highly endangered rodent endemic to a small stretch of the California portion of the Amargosa River basin in the Mojave Desert near Tecopa in Inyo County \[[@B1-microorganisms-06-00094],[@B2-micr... | {
"pile_set_name": "PubMed Central"
} |
**What was known?**
Pemphigus is a chronic disease thereby necessitating the need for prolonged therapy with steroids and/or immunosuppressive medications Affected patient may suffer from profound psychological trauma.
Introduction {#sec1-1}
============
There is a strong interrelationship between mind and skin. Com... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Standards for what is considered appropriate and 'good' living in Western society have never been higher \[[@B1]\]. Media messages that one can (and should) 'have it all' -- family, career, money, happiness and health -- abound (e.g., \[[@B2],[@B3]\]). Yet, with longer work weeks \[[@B4],[@B5]\],... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
*Mycoplasma pneumoniae* (MP) is an "atypical" bacterium that causes acute respiratory infection in humans of all ages. MP is considered a common cause of pneumonia: MP causes about 15--20% adult community-acquired pneumonia (CAP) and up to 40% cases in children; however, not every inf... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Cellular carbohydrates are present in multiple structural configurations, including mono-, oligo-, and polysaccharides, as well as various glycan-hybrid molecules. The latter include, but are not limited to, glycolipids, glycoproteins, proteoglycans, and glycosaminoglycans. Unlike pro... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-22-01892}
===============
Organic light emitting diodes (OLED) have drawn attention for display applications as a thin film light source. Recently, the problem of light trapping in OLED devices has been addressed. Thirty percent of the light is reflected in the interface of glass and a... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Prediabetes is an intermediate state in which blood glucose is above normal but does not meet the clinical diagnostic criteria for diabetes. This state includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both conditions \[[@CR1]\]. The prevalence of diabetes w... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .199}
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"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In preclinical research, different imaging modalities are used for the *in vivo* visualization of functional and anatomical information. Structural imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound provide detailed depictions of anat... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Macrophages are cells of the innate immune system that are found in most tissues. They respond to infection as the first line of defense against pathogens ([@B1]). Macrophages play an important role in the immune response and homeostasis with functional diversity, such as inflammation, ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-animals-10-01040}
===============
Copy-number variations (CNVs) are structural variations widely dispersed in mammalian genomes. Conventionally, CNVs are defined as genomic regions ranging from 50 base pairs (bp) to several Mega bases (Mb), and which are present in the form of deletions, inserti... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Over the last decades, nanotechnology has become increasingly important in industry, biomedicine, and research.[@CIT0001] In industrialized countries, a wide range of nanoparticles (NPs) based on various chemical structures and particle sizes are used.[@CIT0002] The European Union re... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Pulmonary arterial hypertension (PAH) is produced by pulmonary vascular narrowing that results in elevated pulmonary vascular resistance and right heart pressure \[[@B1-healthcare-03-00630]\]. Patients with PAH often are afflicted with the consequences of right heart failure including v... | {
"pile_set_name": "PubMed Central"
} |
Calorie restriction (CR; also called dietary restriction) without malnutrition increases health and lifespan in virtually all species studied[@b1]. Reduced signaling through the nutrient sensitive mechanistic target of rapamycin complex 1 (mTORC1) is thought to mediate many of the beneficial effects of CR[@b2][@b3][@b4... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Ultrasound (US) examination constitutes the first choice test in the diagnostics of the liver gallbladder and bile ducts diseases. The technological advancement ensures constant modification of the US apparatus parameters, which enables to improve the image quality and extends the sc... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Inequities in the delivery of healthcare are unjust differences between populations in the access, use, quality and outcomes of care \[[@CR1]\]. Populations disproportionally impacted by these healthcare inequities include: racial/ethnic minorities, indigenous groups, socioeconomically di... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In women, breast tumours still remain one of the leading causes of cancer-related deaths^[@CR1]^. Currently, breast cancers are classified by different criteria including pathology (lobular, ductal), stage (TNM), grade, receptor status and presence or absence of gene mutation (e.g. BR... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Faltering growth is the failure of children to achieve adequate growth at a normal rate for their age, as a result of inadequate nutritional intake/absorption of nutrients in relation to their requirements. Effective management through nutritional support is important for physical gro... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Lactic acid bacteria (LAB) have been used for centuries for feed and food fermentation \[[@B17]--[@B131]\]. They are frequently taken up in the fermentation of vegetables, fruits, fish, meat, and milk \[[@B143], [@B125]\], improving texture and flavor of bread \[[@B21]\], sausag... | {
"pile_set_name": "PubMed Central"
} |
Problem {#s1}
=======
Tracheostomies are small tubes inserted into the anterior neck to act as artificial airways for around 15,000 adult and paediatric patients in England and Wales annually.[@R1] Temporary tracheostomies are most commonly performed to facilitate weaning from ventilation in the critically ill or as p... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files. Additionally, the original computed tomographic (CT) data for the skull of MDT-PV 2 are freely available at the data repository Dryad (<http://datadryad.org/review?doi=doi:10.5061/dryad.31726>).
Introduction {#sec001}
============
Titanosaur... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
Microgravity is a condition found to exist, when the small collision accelerations are not exceeding 10^−5^ to 10^−4^ × g of background level ([@b0005]). The bacterial cells experience microgravity when force of gravity acting upon them is opposed by another force. Microgravity... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Cystic fibrosis (CF) is the most common genetic disease in the white population and results from mutations in a single gene encoding for a 1480 residue transmembrane glycoprotein, the cystic fibrosis transmembrane conductance regulator (CFTR). Lung disease, characterized by chro... | {
"pile_set_name": "PubMed Central"
} |
The nucleolus, a membrane-free organelle embedded inside the nucleus, has been classically considered as a mere ribosome factory; however, an emerging body of evidence points nowadays towards a more active role in cell homeostasis \[[@r1]\]. The nucleolus is organized around the nucleolar organizing regions (NORs), whi... | {
"pile_set_name": "PubMed Central"
} |
I[NTRODUCTION]{.smallcaps} {#sec1-1}
==========================
Bone marrow edema syndrome (BMES) of the hip is being discussed as a possible early reversible stage of avascular necrosis,[@CIT1]--[@CIT4] but the incidence of progression from bone marrow edema syndrome to avascular necrosis is still unclear. Other auth... | {
"pile_set_name": "PubMed Central"
} |
The microbiologist Jilun Li's excellent work on microbial secondary metabolites and biological nitrogen fixation has made significant contributions to agriculture and has created enormous economic and social benefits in China. He has received many honors throughout his career and was elected as an academician of the Ch... | {
"pile_set_name": "PubMed Central"
} |
*Striacosta albicosta* (Smith), commonly referred to as western bean cutworm, is a significant pest of maize, *Zea mays* (L.), and dry edible bean, *Phaseolus vulgaris* (L.). First identified in Arizona in 1887 ([@CIT0053]), *S. albicosta* is native to the southwestern region of the United States. Reports of economic d... | {
"pile_set_name": "PubMed Central"
} |
Plant biomass and productivity of many ecosystems are limited by the availability of reactive nitrogen, this is reduced or oxidized forms of N. Over the last century synthetic N fertilizers have undoubtedly helped to enhance crop yields, thus allowing an unprecedented growth of the world population. Despite this, nearl... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Significant nanotechnology contributions have been made to a myriad of fields including information technology, medicine, energy, food safety, and environmental science.^[@ref1]−[@ref5]^ In medicine, nanoparticles are poised to revolutionize the established field of drug-delivery.^[@r... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The incidence and prevalence of coronary heart disease (CHD) and acute myocardial infarction (AMI) among the Iranian population has increased. However, acute ST-elevation myocardial infarction (STEMI) is a cardiac emergency with a high early (first hour) mortality rate.[@b1-ARYA-08-46]However... | {
"pile_set_name": "PubMed Central"
} |
**Funding information**
This research was supported by Swiss National Science Foundation (grants \# PBLAP3‐139981 and PBLAP3‐145866), MSD Merck Sharp & Dohme AG, SICPA Foundation, Academic Society of Lausanne. This work was partially funded through the IDEA project "Dissecting the Immunological Interplay between Pover... | {
"pile_set_name": "PubMed Central"
} |
1. Why is the demograpy important? {#s1}
==================================
In the half century 2000-2050, there will be a virtual tsunami of aging in the United States. The anticipated increase in the population older than age 65 is 140%, and for the population older than age 85, 389%. More than half of the current U... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-toxins-08-00223}
===============
TNF is a classical pro-inflammatory cytokine involved in the modulation of acute inflammatory responses and host defense mechanisms \[[@B1-toxins-08-00223]\]. However, increased levels of this cytokine are closely associated with degenerative diseases, such as se... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec001}
============
*Staphylococcus aureus* is a commensal of the skin and mucous membranes, especially the anterior nares (nostrils) in humans and animals. It can cause opportunistic infections following trauma of the skin and mucous membranes \[[@pone.0232913.... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The estimated prevalence of dementia of persons greater than 70 years of age is 14.7% \[[@B1]\]. The yearly cost attributable to dementia is between \$43,000/patient and \$70,000/patient and the total monetary cost of dementia in 2010 was between \$157 billion and \$215 billion. Add to this, the ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Reproductive history, like parity, age at first birth and number of births, has consistently been shown to be associated with breast cancer risk \[[@CR1]\]. Women who have undergone a full time pregnancy before 20 years of age, for example, have a 50% reduced lifetime risk of developi... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Bacterial growth is one of the most representative phenomena of living systems^[@CR1],[@CR2]^, thus, it is foundational in microbiology and the topic has been touched on in countless ways. Nevertheless, the decision factors involved in bacterial growth remain unclear because growing c... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Brucellosis is a severe zoonotic disease distributed worldwide, especially in the developing world (Wang et al., [@B31]). Sheep, goats, cattle, and pigs infected by *Brucella* species are the main sources of human brucellosis (Ducrotoy et al., [@B11]). In the past 10 years, human brucel... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Children with congenital central hypoventilation syndrome (CCHS), a condition marked by a loss of breathing drive during sleep and impaired central sensitivity to CO~2~, show impaired blood pressure and hypoxia responses, unique changes in affect, and problems with memory [@pone.0006436... | {
"pile_set_name": "PubMed Central"
} |
Citation
========
Dantas GPS, Hamada N, Mendes HF (2016) *Denopelopia amicitia*, a new Tanypodinae from Brazil (Diptera, Chironomidae). ZooKeys 553: 107--117. doi: [10.3897/zookeys.553.5988](10.3897/zookeys.553.5988)
Introduction
============
The tanypod genus *Denopelopia* was erected by [@B8] based on a single spe... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-polymers-12-00644}
===============
Epoxy resin, as a versatile high-performance and thermosetting material with acceptable chemical and corrosion resistance and low shrinkage, has been shown to be applicable in industrial fields like adhesives and coatings \[[@B1-polymers-12-00644],[@B2-polymers... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Cardiac hypertrophy, which is characterized by increased cell size, protein synthesis and reactivation of the fetal gene program, is an adaptive physiological process in response to various extracellular stimuli \[[@CR1]\].
Elevated activities of the adrenergic nervous system (ANS) play ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In late December 2019, a severe coronavirus outbreak emerged in China. It was caused by a novel virus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) from *coronoviridae* family \[[@CR1], [@CR2]\]. The infection quickly spread over the world. The World Health Organizatio... | {
"pile_set_name": "PubMed Central"
} |
The novel SARS‐CoV‐2 coronavirus disease (COVID‐19) pandemic continues to accelerate affecting every state in the United States with \>1.8 million cases and \>106 000 deaths as of 4 June 2020.[^1^](#jca21803-bib-0001){ref-type="ref"}, [^2^](#jca21803-bib-0002){ref-type="ref"} Although affected hospitals have both inter... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .98}
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"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Recently, we employed a label-free quantitative proteomics approach to discover new therapeutic targets in tumor-initiating cells (TICs) and/or cancer stem-like cells (CSCs) \[[@R1]\]. Briefly, ER-positive breast cancer lines were cultured under suspension conditions, allowing for the f... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Organisms have endogenous circadian clocks that maintain daily rhythmic activities despite environmental alterations. The circadian clock system consists of three main components: an input pathway, a central oscillator, and an output pathway ([@b1-ksmcb-42-301]). The input pathway transmits e... | {
"pile_set_name": "PubMed Central"
} |
Approximately 75-80% of runners initiate contact with the running surface on their heel and thus have a rearfoot or heel-toe footfall pattern. The remaining 20-25% initially contact the ground with the foot flat with a subsequent heel contact (midfoot pattern) or on their forefoot with no heel contact (forefoot pattern... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
In 1997, a mutant mouse that displayed phenotypes resembling human premature aging syndromes was reported \[[@B1]\]. The aging-like phenotypes included shortened lifespan, atrophy of multiple organs (gonads, thymus, skin, etc.), vascular calcification, cardiac hypertrophy, osteo... | {
"pile_set_name": "PubMed Central"
} |
Humans are highly proficient at detecting animate movement in other agents, or noticing entities that act intentionally in the world, a capacity that has adaptive benefits for behaviour[@b1]. The attribution of agency is so automatic and irresistible that humans attribute agency even to simple two-dimensional shapes th... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
Background/introduction
=======================
In this work we will present our plan for an (MR)-guided, high-intensity focused ultrasound (FUS) uterine fibroid registry, with the goal of providing large-scale evidence on the safety and long-term efficacy of FUS for the treatment of symptomatic uterine fibroids.
Met... | {
"pile_set_name": "PubMed Central"
} |
{
"pile_set_name": "PubMed Central"
} | |
Image in medicine {#sec1}
=================
Large numbers of central venous catheters (CVCs) are placed each year in the intensive care units and misplacement occurs frequently. Many critically ill patients require central venous catheterization for multiple and varied reasons. Internal jugular vein (IJV) catheter is ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The human cytomegalovirus (HCMV), a member of the β-herpesvirus family, is an important pathogen in immunocompromised patients and the leading cause of congenital birth defects with about 1/1,000 newborns affected [@ppat.1001150-Mocarski1]. After primary infection, herpesviruses establi... | {
"pile_set_name": "PubMed Central"
} |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Cisplatin is the most applicable drug for treating various human cancers, however, its efficiency is limited due to development of drug resistance by tumor cells \[[@R1]-[@R3]\]. Cisplatin-induced programmed cell death is associated with expression of specific "cell death" genes and dow... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Follicular lymphoma (FL) is the second most common mature B-cell lymphoma diagnosed in adults in the USA and western Europe \[[@CR1]\]. It is characterized by neoplastic follicles arranged in a back-to-back pattern throughout the lymph node with decreased interfollicular area. The follicl... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
In the last decades, zinc oxide nanoparticles (ZnO NPs), as a new type of high-functional nanoparticles, have been widely used in cosmetics, food additives, biosensors, and pharmaceuticals \[[@B1]-[@B4]\]. With the increased application of ZnO NPs, the concerns about their potential hazards and s... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The 2010 Gulf of Mexico Oil Spill (also called the Deepwater Horizon/BP disaster/oil spill, or Macondo blowout among others) was the largest accidental spill of oil in history ([@B3098378], [@B3098505]). Coupled with the fact that it occurred in the deep sea (\>1000 m depth) and with the coor... | {
"pile_set_name": "PubMed Central"
} |
Protected area data is available from the World Data Base on Protected Areas (WDPA, [www.protectedplanet.net](http://www.protectedplanet.net)). Species distribution maps area available from the The IUCN Red List of Threatened Species (<http://www.iucnredlist.org>). List of priority protected areas by Le Saout et al. 20... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#SEC1}
============
The control of gene expression in mammals relies substantially on the methylation status of genomic DNA. Mammalian DNA methyltransferases methylate cytosines at the ring carbon 5 position, generating 5-methylcytosine (5mC), usually within the dinucleotide sequence context of CpG ([@B1... | {
"pile_set_name": "PubMed Central"
} |
Recommendations for adjuvant systemic therapies are based on estimates of life expectancy (prognostic markers) and of benefit to therapy (predictive markers). The oestrogen receptor is a classic predictive marker guiding use of anti-oestrogen therapy, and expression profiling appears to select patients more or less lik... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Early onset epileptic encephalopathies (EOEEs) encompass a wide variety of early onset seizure disorders invariably associated with difficult-to-treat seizures, developmental delay or stagnation, poor prognosis, and uncertainty regarding standard treatment approaches \[[@B1]\]. ... | {
"pile_set_name": "PubMed Central"
} |
All data are within [S1 Table](#pone.0115739.s001){ref-type="supplementary-material"}. All data are also uploaded in .csv format at <https://www.researchgate.net/profile/Craig_Harms2/contributions?ev=prf_act>.
Introduction {#sec001}
============
The loggerhead sea turtle (*Caretta caretta*) is a marine turtle species... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Labor accident statistics
-------------------------
Numerous labor accidents have happened not only in Japan, but also in many other countries. [Figure 1](#fig_001){ref-type="fig"}Fig.1.Numbers and rates of labor accidents in the construction industry in Japan (2011). shows the numbers... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The cytokine macrophage migration inhibitory factor (MIF) has long been known as a modulator of the immune response towards various infectious agents \[[@B1]-[@B4]\] Over the last years, its role in other disease-related processes, in particular neoplastic disorders, has been elucidated \[[@B5]\]... | {
"pile_set_name": "PubMed Central"
} |
Data from this work are available from the NCBI Sequence Read Archive at <http://www.ncbi.nlm.nih.gov/sra>. BioProject ID: PRJNA416437; BioSample accessions SAMN07956470 to SAMN07956481.
Introduction {#sec001}
============
Bone mass is highly heritable and largely determined by bone growth during childhood and adoles... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Magnetic inhomogeneity from iron and deoxyhemoglobin causes faster T2\* relaxation, leading to signal intensity loss on T2\*-based magnetic resonance images (MRI). Therefore, T2\*-based MRI (T2\*MRI), including the T2\*-weighted gradient recalled echo imaging, or susceptibility weighted imagi... | {
"pile_set_name": "PubMed Central"
} |
Sir,
I read the article entitled, "Percutaneous endoscopic colostomy: A new technique for the treatment of recurrent sigmoid volvulus,"\[[@CIT1]\] with great interest. I would like to congratulate the author for an excellent description of the technique. However, certain aspects need clarification. Author states that ... | {
"pile_set_name": "PubMed Central"
} |
{
"pile_set_name": "PubMed Central"
} | |
1. Background {#sec89852}
=============
Endophyte bacteria is an organism that lives in plant tissues, and acts as symbiont with the host and secreted beneficial products ([@A16784R1]). Examples of metabolites with medicinal value were taxol, cryptocin, and cryptocandin ([@A16784R2]). The study by Zin et al. ([@A16784... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
In sporting activities the knee is the most common joint to be injured and 40% of all knee injuries are due to ligament tears.^[@ref1]^ Within the knee the most commonly injured ligament is the anterior cruciate ligament (ACL) (49%).^[@ref2]^ In the United States of America the inci... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
A perfect inverted repeat (IR) is a stretch of DNA consisting of two DNA sequences (arms) in reverse complement orientation (e.g., 5′ *AGAACAxxxxTGTTCT* 3′). When the arms are directly adjacent to each other, the sequence is called a palindrome (e.g., 5′ *AGAACATGTTCT* 3′). When the arms do n... | {
"pile_set_name": "PubMed Central"
} |
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