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**Abstract** **Economy:** \- worldwide accessibility for food/diminishing quantitative discrepancy between rich and poor countries \- providing a nutritional optimum per capita \- decreasing waste of food **Food Security:** \- tracing/tracking of animals and products \- developing a good agricultural practice \...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== The home is of fundamental importance for the possibilities for people with psychiatric disabilities to lead an everyday life characterized by meaningful activities, being as they spend a greater part of their time in their home setting \[[@CR1]\]. The need to address opportunities for ac...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Spinal cord injury (SCI) represents damage of the spinal cord resulting from a blunt or penetrating trauma, which is a severe disease of the central nervous system (CNS) disrupting important signals between the nervous system and muscles and creating an imbalance that increases muscle a...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Congenital disorders of glycosylation (CDG) are an expanding group of disorders caused by defects in the glycosylation of proteins, and include more than 125 known genetic diseases.^[@R1],[@R2])^ Among the various forms of CDG, those affecting *N*-glycosylation constitute a major subgroup, wh...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ Osteoporotic vertebral fracture is common among elders, which manifests as convex deformation of spinal cord and waist and back pain. Patients with osteoporotic vertebral fracture who has pure pain can be firstly treated by conservative treatment including drug treatment, stay in be...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Musculoskeletal neck pain of extended duration is common, affecting approximately one-fifth of the adult population.[@b1-jpr-10-053],[@b2-jpr-10-053] Of people who experience neck pain at some time point, almost 50% will report recurring or persistent pain complaints some years later.[@b3-jpr...
{ "pile_set_name": "PubMed Central" }
![](hosplond72068-0012){#sp1 .182} ![](hosplond72068-0012-a){#f1 .182}
{ "pile_set_name": "PubMed Central" }
This book begins with foreword by Prof Mandeep S Dhillon, HOD, Deptt of Orthopedics, PGIMER, Chandigarh in which he has rightly portrayed the role of super-specialty field of neurosurgery in the modern world. But along with that he also explains that because this field is new in India, doctors end up being burdened wit...
{ "pile_set_name": "PubMed Central" }
**Disclosures** M.J.G. was an advisory board member, principal investigator, speaker and/or consultant for Abbvie Inc., Actelion Pharmaceuticals, Akros Pharma Inc., AMGEN Inc., Boehringer Ingelheim International GmbH, Bristol‐Myers Squibb Company, Celgene Corporation, Dermira Inc., Eli Lilly and Company, Galderma SA, ...
{ "pile_set_name": "PubMed Central" }
1.. Introduction {#s1} ================ Intraspecific diversity can increase the resilience and stability of species or metapopulations \[[@RSTB20170018C1]\]. This diversity--stability linkage can arise when there are asynchronous population dynamics within the metapopulation. Such asynchrony will increase the potenti...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Patients with masked hypertension (MHT) have been shown to carry a double risk of cardiovascular events compared with normotensive (NT) individuals, comparable to that of patients with sustained hypertension (SHT) [@R1]--[@R3]. MHT has been associated with target organ damage in the heart, ar...
{ "pile_set_name": "PubMed Central" }
Modern DNA sequencing experiments often interrogate hundreds of millions or even billions of reads, possibly to achieve deep coverage or to observe very rare molecules. Low complexity DNA sequencing libraries are problematic in such experiments: many sequenced reads will correspond to the same original molecules and de...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-molecules-24-03541} =============== The disposal of food wastes leads to environmental and economic concerns, due to its high fermentability, high transportation costs, lack of disposal sites, and the difficulties to accumulate organic wastes for a long time \[[@B1-molecules-24-03541]\]. Industr...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The neoplastic transformation of a normal cell, or oncogenesis, can be induced through the dysregulation of specific genes. This usually involves a gain of function in an oncogene and/or loss of function in a tumor suppressor gene. The stringent control of essential cellular mechanisms involv...
{ "pile_set_name": "PubMed Central" }
Introduction {#S0001} ============ Over the past two decades, obesity has become a serious global health problem. The International Association for the Study of Obesity/International Obesity Task Force, a WHO body, has reported that approximately 1 billion adults worldwide are overweight and another 475 million adults...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-antibodies-09-00010} =============== At least one-third, and perhaps as many as one-half, of all functioning proteins are predicted to be metalloproteins \[[@B1-antibodies-09-00010],[@B2-antibodies-09-00010],[@B3-antibodies-09-00010]\]. Included among these metal-dependent biological factors are...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Blepharitis, simply defined as inflammation of the eyelids, is one of the most common ocular conditions encountered by primary eye care providers and accounts for a growing percentage of primary care medical visits.[@b1-opto-8-071],[@b2-opto-8-071] It is an inflammatory condition associated w...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Initial staging of extent of disease is important in patients with newly diagnosed non-small cell lung cancer (NSCLC), in order to direct appropriate therapy and establish prognosis. Patients with disease localized to a pulmonary lobe, with or without hilar lymph node disease, are usually tre...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#S1} ============ Spontaneous low-frequency fluctuations (LFFs) of the BOLD signal are thought to be a manifestation of the ongoing activity of the brain \[[@R1]\]. Such BOLD LFFs are spatially synchronized in the brain, identifying robust and reproducible connectivity patterns also known as resting-stat...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ The release of DSM-IV and DSM-5 made it clear that the operational DSM-III promise and goal of an etiology-anchored classification, failed to materialize \[[@CR1], [@CR2]\]. A need for etiological research progress and its prerequisite, the diagnostic reliability, was the justifying a...
{ "pile_set_name": "PubMed Central" }
Thompson CM, Fitch SE, Ring C, Rish W, Cullen JM, Haws LC. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol. 2019;39:1267--1282. 10.1002/jat.3812 31215065 1. INTRODUCTION {#jat3812-sec-0001} =============== GenX is the trade name for ammonium 2,3,3,3‐tetrafluoro‐2‐(heptafluor...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Adolescent substance use is a major public health concern in the United States. The high rates of substance use coupled with significant unmet treatment needs and the alarming rates of recurrence of use are concerning. Recent estimates suggest that 2.0 million adolescents in the 12- to 17-yea...
{ "pile_set_name": "PubMed Central" }
Editorial Note on the Review Process ==================================== [F1000 Faculty Reviews](http://f1000research.com/browse/f1000-faculty-reviews) are commissioned from members of the prestigious [F1000 Faculty](http://f1000.com/prime/thefaculty) and are edited as a service to readers. In order to make these rev...
{ "pile_set_name": "PubMed Central" }
1 Introduction ============== Genotype imputation methods ([@btv348-B3]; [@btv348-B9]; [@btv348-B13]; [@btv348-B15]; [@btv348-B21]) are commonly used to increase the genomic resolution for large-scale multi-ethnic meta-analyses ([@btv348-B20]; [@btv348-B22]; [@btv348-B23]) by predicting genotypes at unmeasured markers...
{ "pile_set_name": "PubMed Central" }
Autistic Disorders (ADs) are neuro-developmental disorders in the category of pervasive developmental disorders chiefly described by three main deficits: 1) deviant communication, 2) impaired reciprocal social interaction, and 3) limited, repetitive and stereotypic patterns of behaviors or interests ^([@CIT0001])^. The...
{ "pile_set_name": "PubMed Central" }
I. Introduction =============== The proper assembly of the flagellar components is essential for effective flagellar movement of the sperm to swim up as far as the egg for fertilization. In fact, a number of cases of dysplasia of FS have been reported in asthenozoospermic sterile men \[[@B2]\]. In this respect, it is ...
{ "pile_set_name": "PubMed Central" }
Since Darwin, the problem of explaining the evolution of cooperative behavior has been actively investigated in many fields, from Evolutionary Biology, Ecology, to Economics and Social Science. Several mechanisms responsible for the evolution of cooperation have been proposed, from kin and group selection to direct and...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ Barley (*hordeum vulgare* L.) is an important cereal crop grown worldwide with a production of 142 million metric ton (MMT) in 2018--2019 crop year \[[@pone.0232896.ref001]\] with a total production of 3.0...
{ "pile_set_name": "PubMed Central" }
Introducción {#s0005} ============ Se considera enfermedad inflamatoria nasosinusal a la afectación inflamatoria de la mucosa que tapiza las fosas nasales y los senos paranasales; esta mucosa forma parte del aparato respiratorio y, en la actualidad, se considera la *unidad narizbronquio* como una entidad desde el punt...
{ "pile_set_name": "PubMed Central" }
For a long time, medical history was written by physicians, many of whom cast their fellow practitioners in largely hagiographical terms. In the twentieth century, historians, sociologists and philosophers also began to study medicine's past and the result was an important historiographic turn towards more critical soc...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ The human brain outperforms most of the existing artificial neural networks (ANNs) in terms of energy-efficient and error-tolerant computing ([@R1], [@R2]). One of the main differences between ANNs and the human brain is the representation of information ([@R3], [@R4]): While most ANNs repres...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ The *Aeromonads* are halophilic, Gram-negative, rod-shaped, nonspore forming, nonacid-fast facultative aerobes which are widely distributed in the soil, foodstuffs, and aquatic environment.\[[@ref1]\] These emerging enteric pathogens flourish in the water distribution system by form...
{ "pile_set_name": "PubMed Central" }
Introduction {#section1-1178221819862283} ============ Substance use disorder (SUD) is described as a major worldwide issue^[@bibr1-1178221819862283],[@bibr2-1178221819862283]^ and is defined by the *Diagnostic and Statistical Manual of Mental Disorders* (5th ed.) of the American Psychiatric Association (*DSM-5*, 2013...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Benign prostatic hyperplasia (BPH) is a progressive disease that causes lower urinary tract symptoms (LUTS), causes acute urinary retention (AUR), or leads to BPH-related surgery, and it greatly affects quality of life (QoL) \[[@B1],[@B2]\]. It has also been reported that intraprostatic infla...
{ "pile_set_name": "PubMed Central" }
![](envhper00329-0110.tif "scanned-page"){.801} ![](envhper00329-0111.tif "scanned-page"){.802} ![](envhper00329-0112.tif "scanned-page"){.803} ![](envhper00329-0113.tif "scanned-page"){.804} ![](envhper00329-0114.tif "scanned-page"){.805} ![](envhper00329-0115.tif "scanned-page"){.806}
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ In recent years, percutaneous coronary intervention (PCI) has been increasingly used for the revascularization of multi-vessel coronary artery disease (CAD); the optimal method for this purpose is, however, still a matter of controversy.\[[@ref1]\] The success rate of PCI has now re...
{ "pile_set_name": "PubMed Central" }
**Core tip:** Saliva is a useful source for analysis of proteins that can be associated in many diseases, including proliferative verrucous leukoplakia (PVL). This study showed that angiotensinogen and dipeptidyl peptidase 1 may be important in PVL development. INTRODUCTION ============ Proliferative verrucous leukop...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Eating disorders are serious psychiatric conditions with high rates of morbidity and mortality. They are associated with a staggering socioeconomic cost of almost \$70 billion per year in Australia alone \[[@CR1]\]. Anorexia nervosa is associated with the most serious consequences, having...
{ "pile_set_name": "PubMed Central" }
![](brjcancer00027-0117.tif "scanned-page"){.1805} ![](brjcancer00027-0118.tif "scanned-page"){.1806} ![](brjcancer00027-0119.tif "scanned-page"){.1807} ![](brjcancer00027-0120.tif "scanned-page"){.1808} ![](brjcancer00027-0121.tif "scanned-page"){.1809} ![](brjcancer00027-0122.tif "scanned-page"){.1810} ![](brjc...
{ "pile_set_name": "PubMed Central" }
Introduction {#S1} ============ Age-related cognitive decline is associated with increased risk of disability, dementia, and death. Especially in Western societies this problem is expected to increase in the coming decades, underscoring the need for strategies to reduce the chance of cognitive decline (Alzheimer's Ass...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary early-onset vascular disease causing recurrent ischemic subcortical infarcts, generally accompanied by migraine, cognitive impairment, psychiatric symptoms and progressively se...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-materials-11-01821} =============== Selective laser melting technology adopts single-point high-energy laser beam to melt metal powder layer by layer along the filling path of three-dimensional discrete profile. Theoretically, it is not constrained by the structure of the part and can fabricated...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#s0005} =============== Men of African ancestry have a significantly higher rate of prostate cancer (CaP) incidence and mortality in the United States and globally ([@bb0240]). Accumulating evidence from our group and others support the contention that biological and genetic alterations differ in prev...
{ "pile_set_name": "PubMed Central" }
1. Adipose-Derived Stem Cells (ASCs) {#sec1-ijms-19-01897} ==================================== Adipose-derived stem cells (ASCs) are adult multipotent cells with homing, immunomodulation, promotion of tissue repair and regeneration properties. Moreover, their clinical use, unlike embryonic stem cells, is less associa...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Functional Capacity Evaluations (FCEs) are batteries of tests aimed to measure a person's performance of work-related tasks. Actual performance of patients with chronic non-specific low back pain (CLBP) during an FCE may depend on several factors. Seen from the biopsychosocial model, ...
{ "pile_set_name": "PubMed Central" }
This study was not supported by any grant. This work was done at the Royal Veterinary College, Vetsuisse Faculty, Highcroft Veterinary Referrals and North Downs Specialist Referrals. The results of this study were presented as an abstract at the 26th ECVIM‐CA Annual Congress 2016, Gothenburg, Sweden. 95% CI : 95%...
{ "pile_set_name": "PubMed Central" }
Background ========== Bacterial meningitis (BM) is a life-threatening disease, often related with serious complications and sequelae. During the last decades the disease epidemiology has changed dramatically in the countries that adopted the conjugate vaccines against *Haemophilus influenza*type b (Hib), *Neisseria me...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Genitourinary (GU) malignancies encompass a heterogenous group of cancers pertaining to a specific anatomical and physiological function. There is incredible biological diversity among primary genitourinary malignancies \[[@CR1]\]. Renal cell carcinoma (RCC); urothelial carcinoma of t...
{ "pile_set_name": "PubMed Central" }
Background ========== Wilson's disease (WD) is an autosomal recessive inherited disorder of copper metabolism. It affects between one in 30 000 and one in 100 000 individuals, and the carrier frequency is approximately one in 90 \[[@b1-amjcaserep-19-304]\]. This rare disease is caused by mutations in a gene encoding a...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Hypertension and *diabetes mellitus* are among the major causes of death due to non-communicable chronic diseases (NCDs) worldwide, with a global prevalence of 22% in hypertensive individuals, and approximately 9.4 million related deaths per year.^[@B1]^ Global prevalence in diabetic individu...
{ "pile_set_name": "PubMed Central" }
![](indmedgaz72916-0050){#sp1 .538}
{ "pile_set_name": "PubMed Central" }
Introduction ============ Visna/maedi virus (VMV) and caprine arthritis encephalitis virus (CAEV) belong to the small ruminant lentivirus (SRLV) group, within the non-oncogenic lentivirus genus of the Retroviridae family, which includes the human immunodeficiency virus (HIV), simian immunodeficiency virus (SIV), felin...
{ "pile_set_name": "PubMed Central" }
TARGET TEMPERATURE MANAGEMENT IN 2016 ===================================== Target temperature management (TTM) is well-known to reduce secondary cell damage after cardiac arrest in patients with presumed cerebral hypoxia. The treatment of this reperfusion syndrome, especially in terms of temperature management, is no...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
I[NTRODUCTION]{.smallcaps} {#sec1-1} ========================== Infection control in dental clinics and laboratories has become an important concern in recent years due to the increased risk of cross-contamination with diseases such as HIV and hepatitis B.\[[@ref1]\] The impression is the prototype of the victorious ...
{ "pile_set_name": "PubMed Central" }
Educational Objectives {#s5} ====================== By the end of this workshop, learners will be able to: 1.Describe diverse trainees\' perceptions of the academic appointment and promotion processes.2.Define the terms *portfolio, faculty tracks,* and *promotion package.*3.Compare data elements for different CVs and ...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Trauma accounts for 9.6% of global mortality and is the leading cause of death during the first four decades of life \[[@CR1], [@CR2]\]. Since trauma patients are typically relatively young, the amount of Disability-Adjusted Life Years (DALYs) lost due to trauma, is larger than from any o...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-materials-13-00852} =============== Flexible road pavements consist in upper asphalt layers over one or more unbound granular layers which are together compacted over a suitable soil subgrade. They represent approximately 60% of the road network in France. Unbound granular materials (UGM) are c...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the manuscript and its Supporting Information files. Introduction {#sec001} ============ *Bacillus cereus* is well known as a spore-forming, food-associated bacterium which is able to produce enteropathogenic toxins. Besides the cytotoxin K \[[@pone.0214536.ref001]\], two major enterotoxi...
{ "pile_set_name": "PubMed Central" }
The integrity and proper expression of an organism's genome are paramount to its survival. To this end, there exist numerous enzymes that modify DNA, either to repair mismatched or damaged nucleotides^[@ref1]^ or to exert epigenetic control of gene expression.^[@ref2]^ These enzymes distort the DNA double-helical struc...
{ "pile_set_name": "PubMed Central" }
1. Case History {#sec1} =============== A male aged 32 years was admitted to Intensive Care Unit (ICU) from General Surgery in a tertiary hospital (Hospital Virgen del Puerto, Plasencia, Extremadura, Spain). Case history revealed intestinal pathology with peritonitis, and laparotomy with intestinal resection, approxim...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== According to the World Health Organization (WHO), oral disease is one of the most prevalent health care problems \[[@B1]\]. Dental caries are the most frequent form of oral disease and are considered a public health problem affecting both children and adults worldwide and often ...
{ "pile_set_name": "PubMed Central" }
Introduction {#s001} ============ Vaginoplasty, the surgical creation of a vagina, is performed as vaginal reconstruction in nontransgender women with vaginal absence or as gender-affirming surgery in transgender women. While different surgical techniques exist for the latter group, penile inversion vaginoplasty is th...
{ "pile_set_name": "PubMed Central" }
Introduction ============ A wealth of biodiversity data is available online and dynamically indexing these often disparate resources will be pivotal for all the biodiversity sciences ([@B4905503], [@B4905751]). The inherent heterogeneity of biodiversity information found within and across databases can make it difficu...
{ "pile_set_name": "PubMed Central" }
Raw data is available from"Open Science Network" (URL: <https://osf.io/mdgx3/>). 1. Introduction {#sec005} =============== Analyses of human peripheral blood mononuclear cells (PBMCs) can be done on freshly collected blood samples or on cryopreserved samples. Analysis of freshly collected samples is usually preferred...
{ "pile_set_name": "PubMed Central" }
1.. INTRODUCTION {#s1} ================ The rate of cesarean section delivery is increasing globally, with an estimated annual increase of 4% \[[@B1]\]. Yet, the increase in surgical deliveries has not coincided with a global improvement in maternal and infant outcomes, particularly maternal mortality and severe morbi...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== The rise in obesity rates over the past several decades coincides with an increased disease burden in obese individuals and their children. Accumulating epidemiologic and experimental evidence strongly suggests maternal obesity and improper prenatal nutrition provide maladaptive...
{ "pile_set_name": "PubMed Central" }
 == Dear Editor, Curcumin extracted from the **Curcuma longa** rhizome is the major constituent of turmeric and used as a spice in food preparation. Since this substance is available everywhere and could be obtained with a reasonable price, we decided to conduct various researches on it thoroughly. It was considere...
{ "pile_set_name": "PubMed Central" }
Background ========== In recent decades, increases have been observed in antibiotic consumption and resistance to antimicrobials, mainly in large hospitals \[[@B1]\]. More than half of all patients admitted receive antibiotics. It is believed that 25--50% of all prescribed antibiotics are inappropriate in respect of d...
{ "pile_set_name": "PubMed Central" }
Extreme sea levels can have profound impacts on coastal areas, including significant loss of life and damage to property and to the environment. They cause billion-dollar disaster events in countries across the globe and floods related to sea level now cost the world 10s of billions of dollars each year ([@r1]). And wi...
{ "pile_set_name": "PubMed Central" }
1.. Introduction {#S0001} ================ The Newton-like dynamical system$$\begin{array}{r} \left\{ \begin{array}{l} {\overset{¨}{x}{(t)} + \gamma\overset{˙}{x}{(t)} + \lambda\nabla^{2}\Phi{(x{(t)})}{(\overset{˙}{x}{(t)})} + \nabla\Phi{(x{(t)})} = 0} \\ {x{(0)} = u_{0},\overset{˙}{x}{(0)} = v_{0},} \\ \end{array} \r...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Conventional diffusion tensor imaging (DTI) has become an important tool in clinical research and neuroscience (e.g., Zatorre et al., [@B75]; Filippi and Rocca, [@B22]). The interest in DTI is mainly elicited by two applications: DTI-based indices, such as the fractional anisotropy (FA)...
{ "pile_set_name": "PubMed Central" }
Background ========== Histone lysine acetylation plays a central role in the epigenetic regulation of gene expression \[[@B1]-[@B3]\]. The levels of histone acetylation in eukaryotic cells are governed by the opposing activities of histone acetyltransferases(HATs) and histone deacetylases (HDACs) \[[@B3]\]. The mammal...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Cycloaddition reactions belong to the most important classes of organic reactions, and \[3 + 2\]- cycloadditions, also known as 1,3-dipolar cycloadditions or Huisgen reactions, offer a universal tool for the preparation of five-membered heterocycles with a variable number of heteroatoms in th...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Traumatic spondylolisthesis of the axis is considered one of the most frequent forms of upper cervical spine injury. The injury comprises 4 to 7% of all traumatic cervical spine fractures and is classified based on the system described by Effendi et al with modifications proposed by Levine an...
{ "pile_set_name": "PubMed Central" }
Fig A and Fig B are omitted from the [S1 Appendix](#pone.0176249.s001){ref-type="supplementary-material"} file. Please see the complete, corrected [S1 Appendix](#pone.0176249.s001){ref-type="supplementary-material"} here. Supporting information {#sec001} ====================== ###### Fig A in S1 Appendix SDS-PAGE s...
{ "pile_set_name": "PubMed Central" }
Case Presentation {#sec1_1} ================= A 20-year-old female with extensive terminal ileal and colonic Crohn\'s disease was initially successfully managed on a drug regimen of prednisolone and mesalazine which helped to induce remission. The patient unfortunately however developed a mesalazine-induced aplastic a...
{ "pile_set_name": "PubMed Central" }
β-Adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands such as adrenaline and noradrenaline[@R1],[@R2]. Synthetic ligands have been developed that either activate or inhibit βARs for the treatment of asthma, hypertension or...
{ "pile_set_name": "PubMed Central" }
**Session:** 134. Fungi and Parasites in Immunocompromised Patients *Friday, October 5, 2018: 12:30 PM*
{ "pile_set_name": "PubMed Central" }
Introduction ============ Cerebrovascular diseases are currently the third-most important cause of death in several developed and developing countries. The European incidence of cerebral infarction is 1.35-2.2 / 1,000 inhabitants, and 83% of cases are associated to ischemic etiology[@B1]. According to the National Ins...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Traumatic brain injury (TBI) is considered to be the leading cause of death and disability in children ([@B1], [@B2]). Neurological and psychological deficits resulting from TBI can be a high burden for patients and their relatives, deeply affecting the child\'s physical, cognitive and ...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1_1} ============ Chronic kidney disease (CKD) is a growing public health problem in the world, and renal replacement therapy (RRT) national renal registries, including that of Estonia, have reported a continuous increase of RRT patients during the last decades \[[@B1]\]. Main factors responsible for...
{ "pile_set_name": "PubMed Central" }
Background ========== The blood hyperserotonemia of autism is an increase in the serotonin (5-hydroxytryptamine, 5-HT) levels in the blood platelets of a large subset of autistic individuals. It is usually reported as mean platelet 5-HT elevations of 25% to 50% in representative autistic groups \[[@B1]\] that almost i...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1_1} ============ Before 1993, the former viruses of present norovirus were diagnosed by means of electron microscopy using stool samples. They were called in the literature, according to their shape, 'small round structured virus' (SRSV), or due to their similarity to the Norwalk agent (Norwalk-like...
{ "pile_set_name": "PubMed Central" }
![](edinbmedj74974-0072){#sp1 .370} ![](edinbmedj74974-0073){#sp2 .371}
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Currently, eight types (type I to type VIII) of secretion systems in Gram-negative bacteria have been identified according to their outer membrane secretion mechanisms [@pone.0084439-Desvaux1]. With these systems, various types of proteins and virulence factors are secreted and transpor...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Vegetation productivity is the foundation of carbon sequestration and grain yield formation. For the limit on field observation techniques, early studies mainly focused on photosynthesis at the leaf level. The biochemistry and ecophysiology of leaf photosynthesis have been well understo...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== A large body of evidence suggests that antiretroviral therapy (ART), particularly with newer treatment regimens, markedly reduces the risk of sexual transmission of HIV. Recent systematic reviews have estimated that ART causes a more than ten-fold reduction in the incidence rate within di...
{ "pile_set_name": "PubMed Central" }
**Abstract** Electroconvulsive therapy (ECT) is an effective treatment option in major depression. Despite its approved effectiveness the underlying neurobiological mechanisms remain unclear. Neuroimaging findings particularly stress an involvement of the serotonergic neurotransmitter system in its mode of action \[1\...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Mucins are high-molecular-weight glycoproteins prominently expressed in the respiratory, gastrointestinal, and reproductive tracts. The human mucin (MUC) family contains mostly secreted and transmembrane mucins, both of which function as physical barriers [@B1]-[@B4]. MUC1, a type I transmemb...
{ "pile_set_name": "PubMed Central" }
***Background.*** *Clostridium difficile* infection (CDI) is a common cause of nosocomial diarrhea. It can result in severe complications and death, especially among immunocompromised hosts. We conducted a single-center, retrospective cohort study to characterize CDI in lung transplant (LT) recipients (R). ***Methods....
{ "pile_set_name": "PubMed Central" }
Introduction {#s0001} ============ Attention-deficit hyperactivity disorder (ADHD) is a frequently occurring psychiatric condition in school-aged children with estimates of prevalence ranging from 3% to 5% (National Institutes of Health \[NIH\] Consensus Development Panel, [@CIT0048]; Westby & Watson, [@CIT0074]). As ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Allergic asthma is a chronic disease that clinically augments bronchial hyperresponsiveness and inflammation. The asthmatic inflammation is clearly associated with the high level of type 2 T cell (Th2) cytokines that induced immunoglobulin (Ig) E production and eosinophilic infi...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Dietary lipids strongly influence patterns of daily torpor and hibernation, i.e., states of reduced metabolic rate and hence body temperature (T~b~). Heterothermic mammals fed diets containing plant oils that are rich in polyunsaturated fatty acids (PUFAs) show a higher propensity of torpor u...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Gastric carcinoma (GC) is the fifth most common malignant tumor and the second most common cause of cancer-associated mortality worldwide ([@b1-ol-0-0-10642]). Diagnosis and treatment methods for GC have improved each year, but the prognosis for patients remains poor. GC recurrence and metast...
{ "pile_set_name": "PubMed Central" }
In this issue of Annals of Cardiac Anaesthesia, the authors describe the use of autologous umbilical cord blood (UCB) at the 3^rd^ week of life during arterial switch operation for surgical correction of transposition of great arteries.\[[@ref1]\] Laboratory studies\[[@ref2][@ref3]\] have demonstrated and clinical use ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Oligodendrogliomas (ODGs), predominantly occur in adults with a peak between 40 and 60 years of age, constitute 5--20% of all gliomas \[[@CR1]\]. Patients with low-grade (ODG2) are slightly younger than those with high-grade, anaplastic tumors (ODG3) \[[@CR2]\]. The co-deletion of the sho...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }