question stringlengths 13 215 | ground_truth stringlengths 2 3.15k | context stringlengths 0 157k |
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What is the target of Sotorasib? | Sotorasib is a KRASG12C inhibitor. | Author information:
(1)From the Department of Investigational Cancer Therapeutics, Phase I Clinical
Trials Program, University of Texas M.D. Anderson Cancer Center, Houston
(D.S.H., F.M.-B.); the Department of Medical Oncology and Experimental
Therapeutics, City of Hope Comprehensive Cancer Center, Duarte (M.G.F.), ... |
Is ASF1 phopshorylated by the Tousled-like kinases? | Yes,
Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-like kinases (TLKs). | BACKGROUND: The Tousled Like Kinases (TLKs) are involved in chromatin dynamics,
including DNA replication and repair, transcription, and chromosome segregation.
Indeed, the first two TLK1 substrates were identified as the histone H3 and Asf1
(a histone H3/H4 chaperone), which immediately suggested a function in chro... |
What is Luteolin? | Luteolin has been reviewed as a flavonoid possessing potential cardioprotective, anti-inflammatory, anti-cancer activities. | Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an
important member of the TNF superfamily with great potential in cancer therapy.
Luteolin is a dietary flavonoid commonly found in some medicinal plants. Here we
found that pretreatment with a noncytotoxic concentration of luteolin
significa... |
Does sphingosine-1 phosphoate suppress epiregulin? | Sphingosine-1 phosphate induces epiregulin (EREG) gene expression. | BACKGROUND AND AIMS: Sphingosine-1 phosphate (S1P) is a lysosphingolipid present
in the ovarian follicular fluid. The role of the lysosphingolipid in gonads of
the female is widely unclear. At omolar concentrations, S1P binds and
activates five specific G protein-coupled receptors (GPCRs), known as S1P1-5,
modulati... |
Which is the literature-based database of phenotypes? | PheneBank is a Web-portal for retrieving human phenotype-disease associations that have been text-mined from the whole of Medline. This approach exploits state-of-the-art machine learning for concept identification by utilising an expert annotated rare disease corpus from the PMC Text Mining subset. Evaluation of the s... | MOTIVATION: Significant effort has been spent by curators to create coding
systems for phenotypes such as the Human Phenotype Ontology, as well as
disease-phenotype annotations. We aim to support the discovery of
literature-based phenotypes and integrate them into the knowledge discovery
process.
RESULTS: PheneBank... |
Idecabtagene vicleucel can be used for treatment of which disease? | Idecabtagene vicleucel was shown to be effective for Relapsed and Refractory Multiple Myeloma. | BACKGROUND AND OBJECTIVE: Registrational trials for ciltacabtagene autoleucel
[cilta-cel]) and idecabtagene vicleucel [ide-cel] chimeric antigen receptor
T-cell (CAR-T) therapies were single-arm studies conducted with relapse
refractory multiple myeloma (MM) patients who were triple-class-exposed (TCE) or
triple-cl... |
LINC00339 is a diagnostic, prognostic and treatment efficacy biomarker for what disease? | LINC00339 as a cancer diagnostic, prognostic and treatment efficacy biomarker. | Glioma is recognized as a highly angiogenic maligt brain tumor. Vasculogenic
mimicry (VM) greatly restricts the therapeutic effect of anti-angiogenic tumor
therapy for glioma patients. However, the molecular mechanisms of VM formation
in glioma remain unclear. Here, we demonstrated that LINC00339 was upregulated
in... |
What is the role of PCAT6 in human cancers? | PCAT6, is a carcinogenic lncRNA. It is abnormally elevated in various human malignant tumors. PCAT6 has been found to sponge various miRNAs to activate the signaling pathways, which further affects tumor cell proliferation, migration, invasion, cycle, apoptosis, radioresistance, and chemoresistance. It is believed to h... | Long noncoding RNAs (lncRNAs) play crucial roles in tumor development of
osteosarcoma (OS). LncRNA PCAT6 was involved in the progression of multiple
human cancers. However, the biological function of PCAT6 in OS remains largely
unknown. We found that PCAT6 was elevated in OS tissues relative to that in
their adjace... |
Can whole genome sequencing be used for diagnosis of mitochondrial disease? | Yes. Whole genome sequencing is a useful diagnostic test in patients with suspected mitochondrial disorders, yielding a diagnosis in a further 31% after exclusion of common causes. Most diagnoses were non-mitochondrial disorders and included developmental disorders with intellectual disability, epileptic encephalopathi... | |
What are the targets of avapritinib? | Avapritinib is a novel inhibitor of KIT/PDGFRA. It is approved in the U.S. for the treatment of adults with PDGFRA exon 18-mutant unresectable or metastatic gastrointestinal stromal tumors. | In a phase I trial of avapritinib (formerly BLU-285), which targets D816V mutant
KIT, for the treatment of advanced systemic mastocytosis, patients experienced
rapid and durable disease control. The overall response rate was 72%, and 56% of
patients experienced a complete or partial response. No patients discontinue... |
What is Jackhammer esophagus? | Jackhammer esophagus (JE) is a hypercontractile esophageal motor disorder defined by at least two swallows with a distal contractile integral (DCI) >8000 mm Hg.s.cm during high-resolution manometry (HRM). | Nutcracker esophagus and jackhammer esophagus are largely unknown motility
disorders, also sometimes called hypertensive and hypercontractile peristalsis,
respectively. There is currently no standardized diagnostic or management plan
for these diseases. Here, we report on three patients with jackhammer/nutcracker
e... |
Can METTL3 methylate long noncoding RNAs? | Yes, METTL3 can modulate methylation and expression of lncRNA. | OBJECTIVES: This study aimed to explore the regulatory mechanism of
methyltransferase3 (METTL3) -mediated long non-coding RNA (lncRNA)
N6-methyladenosine (m6A) modification in the osteogenic differentiation of human
adipose-derived stem cells (hASCs) induced by NEL-like 1 protein (NELL-1).
MATERIALS AND METHODS: Met... |
Which disease is caused by repeat expansion in VWA1? | An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy. | Author information:
(1)NIHR Biomedical Research Centre, Wellcome Centre for Human Genetics,
University of Oxford, Oxford, UK.
(2)Department of Neuromuscular Disorders, UCL Queen Square Institute of
Neurology, London, UK.
(3)Neuromuscular and Neurogenetic Disorders of Childhood Section, NINDS,
National Institutes of ... |
What is the use of the Apfel Score? | The Apfel simplified risk score, developed in 1999, is the most widely used tool for risk stratification of postoperative nausea and vomiting. | PURPOSE: To compare two of the latest published scores for predicting
postoperative nausea and vomiting (PONV) in potentially high-risk patients.
METHODS: Adult in-patients scheduled for throat, thyroid, breast or
gynecological surgery under general inhalational anesthesia were studied
prospectively over 24 hr for P... |
Is PPROM a condition that occurs in males or females? | Preterm premature rupture of fetal membranes (PPROM) occurs in pregnant females. | Objective: To show that infants delivered prematurely because of preterm
premature rupture of the membranes (PPROM) show a tendency for asymmetric
intrauterine growth retardation (IUGR). At the same time, to demonstrate that
these pregcies exhibit nutritional deprivation by the presence of
correspondingly smaller p... |
What is EpiMethylTag? | EpiMethylTag is a fast, low-input, low sequencing depth method, that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylation on the same DNA. | Author information:
(1)New York University Langone Health, New York, NY, USA.
(2)New York Genome Center, New York, NY, USA.
(3)Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
(4)Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York,
NY, USA.
(5)Skirball Institute of Biomolecular Me... |
What is the target of Sutimlimab? | Sutimlimab is a novel humanized monoclonal antibody directed against classical pathway complement factor C1s. | Cold agglutinin disease is a difficult-to-treat autoimmune hemolytic anemia in
which immunoglobulin M antibodies bind to erythrocytes and fix complement,
resulting in predomitly extravascular hemolysis. This trial tested the
hypothesis that the anti-C1s antibody sutimlimab would ameliorate hemolytic
anemia. Ten pat... |
Can parasite infections by Schistosoma japonicum prevent or improve asthma? | A peptide named as SJMHE1 from Schistosoma japonicum can suppress asthma in mice. | A number of epidemiological and clinical studies have suggested an inverse
association between allergy and helminth infection, such as Schistosomiasis.
Therefore, we hypothesize that Schistosoma japonicum egg antigens, a type of
native antigen, can induce production of CD4(+) CD25(+) T cells with regulatory
activit... |
Describe Multilocus Inherited Neoplasia Allele Syndrome (MINAS) | Genetic testing of hereditary cancer using comprehensive gene panels can identify patients with more than one pathogenic mutation in high and/or moderate-risk-associated cancer genes. This phenomenon is known as multilocus inherited neoplasia alleles syndrome (MINAS), which has been potentially linked to more severe cl... | IMPORTANCE: Genetic testing of hereditary cancer using comprehensive gene panels
can identify patients with more than one pathogenic mutation in high and/or
moderate-risk-associated cancer genes. This phenomenon is known as multilocus
inherited neoplasia alleles syndrome (MINAS), which has been potentially linked
t... |
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