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Astronomy &Astrophysics A&A 658, A135 (2022)
https://doi.org/10.1051/0004-6361/202141662
© J. M. Winters et al. 2022
Molecules, shocks, and disk in the axi-symmetric wind of the
MS-type AGB star RS Cancri?
J. M. Winters1
, D. T. Hoai2
, K. T. Wong1
, W.-J. Kim3,4
, P. T. Nhung2
, P. Tuan-Anh2
, P. Lesaffre5
,
P. Darriu... | 10.1051_0004-6361_202141662 | page_0000 |
A&A 658, A135 (2022)
We have concentrated our efforts on two relatively close
(d150pc) sources that show composite profiles in CO rota-
tional lines (Winters et al. 2003): EP Aqr (Winters et al. 2007,
hereafter referred to as W2007), and RS Cnc (Libert et al. 2010).
Data obtained at IRAM show that these two sources hav... | 10.1051_0004-6361_202141662 | page_0001 |
J. M. Winters et al.: Molecules, shocks, and disk in the axi-symmetric wind of the MS-type AGB star RS Cancri
Table 1. Properties of the combined data sets for all detected lines.
Line Frequency Eu=k Peak flux FWHP beam size PA 1 noise vel.res Comments(a)
(GHz) (K) (Jy) (arcsec) (arcsec2) (deg) (mJy beam 1) ( km s 1)
1... | 10.1051_0004-6361_202141662 | page_0002 |
A&A 658, A135 (2022)
Fig. 1. Overview of the frequency ranges observed with PolyFiX using two spectral setups (setup1: red and setup2: blue, respectively). Lower
diagrams : zoom onto the individual spectra covering 7.8 GHz each. Upper row : setup1, lower row : setup2. The central 20 MHz at the border
between inner and ... | 10.1051_0004-6361_202141662 | page_0003 |
J. M. Winters et al.: Molecules, shocks, and disk in the axi-symmetric wind of the MS-type AGB star RS Cancri
Fig. 2. Continuum map around 247 GHz from A-configuration. Con-
tours are plotted in 100 steps, where 1 is 47.6 Jy beam 1. The
synthesized beam is indicated in the lower left corner.
Fig. 3. CO line profiles, ... | 10.1051_0004-6361_202141662 | page_0004 |
A&A 658, A135 (2022)
Fig. 6. Profile around the SiO( v=2,J=5–4) line frequency. A-
configuration and D-configuration merged. The spectral resolution is
1 km s 1and the emission is integrated over the central 100100aperture.
the idea that the SiO masers are excited by infrared pumping as
opposed to collisional pumping (se... | 10.1051_0004-6361_202141662 | page_0005 |
J. M. Winters et al.: Molecules, shocks, and disk in the axi-symmetric wind of the MS-type AGB star RS Cancri
).
Fig. 8. HCN line profiles. Left: HCN(3–2); A-configuration and D-
configuration merged with a spectral resolution of 0.5 km s 1.Right :
H13CN(3–2); A-configuration and D-configuration merged with a spec-
tral res... | 10.1051_0004-6361_202141662 | page_0006 |
A&A 658, A135 (2022)
Fig. 10. Profiles of the four detected SO lines, with A-configuration
and D-configuration merged. The spectral resolution is 3 km s 1and the
emission is integrated over the central 200200aperture.
Fig. 11. Profiles of the two34SO lines detected here, with A-
configuration and D-configuration merged. The... | 10.1051_0004-6361_202141662 | page_0007 |
J. M. Winters et al.: Molecules, shocks, and disk in the axi-symmetric wind of the MS-type AGB star RS Cancri
Table 2. Parameters of the detected SO 2lines used for the population diagram analysis.
Frequency WI=R
S(v)dv g ulog10(Aul) Eu=kab
(GHz) (Jy km s 1) (s 1) (K) (arcsec2)
214.6894 0.1410.0385 33 –4.0043 147.8... | 10.1051_0004-6361_202141662 | page_0008 |
A&A 658, A135 (2022)
AGB stars, such as W Hya (Vlemmings et al. 2017), EP Aqr
(Tuan-Anh et al. 2019), oCet (Hoai et al. 2020), R Dor (Decin
et al. 2018; Nhung et al. 2019a, 2021), and in 15 out of 17 sources
observed in the ALMA Large Program ATOMIUM (Decin et al.
2020; Gottlieb et al. 2022), calling for a common mecha... | 10.1051_0004-6361_202141662 | page_0009 |
J. M. Winters et al.: Molecules, shocks, and disk in the axi-symmetric wind of the MS-type AGB star RS Cancri
Fig. 17. First-moment maps of different lines, indicating a possibly rotating structure (see Sect. 3.4). Left: HCN(3–2), middle left : SO 2(14(0,14)–
13(1,13)), middle right : SiO(v=1,6–5), right : SO(7(6)–6(5)... | 10.1051_0004-6361_202141662 | page_0010 |
A&A 587, A91 (2016)
about their formation paths during the past evolution of the core.
In particular, their degree of deuterium fractionation is a relic of
the conditions that were prevailing in earlier, colder stages (e.g.Taquet et al. 2012 ,2014 ;Aikawa et al. 2012 ).
Apart from methanol, relativ ely little is known ... | 10.1051_0004-6361_201527268 | page_0001 |
A. Belloche et al.: Deuterated complex organic molecules in Sgr B2(N2)
Table 1. Observational setups of the EMoCA survey.
Setup Frequency range Date of tstartaNabBaseline tintdCalibratorsePeakf
LSB USB observation (UTC) rangecBA P ΔαΔδ
GHz GHz yyyy-mm-dd hh:mm m min/prime/prime /prime/prime
S1 84.1–87.8 96.2–99.8 2012-... | 10.1051_0004-6361_201527268 | page_0002 |
A&A 587, A91 (2016)
Table 2. Beam sizes and noise levels.
Setup SPWaFrequency Synthesized beam rmsc
range HPBW PAbmJy
MHz/prime/prime×/prime/prime ◦beam−1K
S1 0 84 091–85 966 2 .1×1.5−85 3.0 0.16
1 85 904–87 779 2 .0×1.5−83 2.7 0.14
2 96 154–98 029 1 .8×1.4−85 3.0 0.16
3 97 904–99 779 1 .8×1.3−85 3.1 0.16
S2 0 87 729–8... | 10.1051_0004-6361_201527268 | page_0003 |
A. Belloche et al.: Deuterated complex organic molecules in Sgr B2(N2)
based on Nguyen et al. (2013 ). Predictions for CH 3CN in its
/v18=1 and 2 excited states are based on preliminary results from
Müller et al. (2015 ), those in /v14=1 are preliminary data from
a subsequent study (Müller et al., in prep.). Transition... | 10.1051_0004-6361_201527268 | page_0004 |
A&A 587, A91 (2016)
Table 3. Rotational temperatures derived from population diagrams of
selected (complex) organic molecules toward Sgr B2(N2).
Molecule StatesaTfitb
(K)
CH 3CN /v18=1,/v18=2,/v14=1 253 (15)
13CH 3CN /v1=0,/v18=1 168 (13)
CH 313CN /v1=0,/v18=1 165.5 (3.3)
CH 2DCN /v1=0 136 (14)
C2H5CN /v1=0 137.3 (1.6)
... | 10.1051_0004-6361_201527268 | page_0005 |
A. Belloche et al.: Deuterated complex organic molecules in Sgr B2(N2)
Table 4. Parameters of our best-fit LTE model (or upper limit) of selected (complex) organic molecules toward Sgr B2(N2).
Molecule StatusaNdetbSizecTrotdNeCfΔVgVoffh Nref
Ni30 mj
(/prime/prime)( K ) ( c m−2)( k m s−1)( k m s−1)
CH 3CN, /v18=1⋆d 20 1.4... | 10.1051_0004-6361_201527268 | page_0006 |
A&A 587, A91 (2016)
Fig. 1. Deconvolved major, minor, and mean sizes (FWHM) derived for uncontaminated C 2H5CN transitions detected toward Sgr B2(N2) and
plotted as a function of upper level energy. The symbols code for the spectral setup (S1 to S5, like in Table 2). In each panel, the dashed line
indicates the median ... | 10.1051_0004-6361_201527268 | page_0007 |
A. Belloche et al.: Deuterated complex organic molecules in Sgr B2(N2)
vibrationally excited state /v19=1. The detection of DC 3N is only
tentative, and its column density should rather be considered as
an upper limit.
5.4. Deuterated methanol CH 2DOH
Methanol and its13Ca n d18O isotopologues are well detected
toward S... | 10.1051_0004-6361_201527268 | page_0008 |
A&A 587, A91 (2016)
Table 5. Deuterium fractionation of selected (complex) organic
molecules toward Sgr B2(N2) compared to predictions of astrochem-ical models.
Molecule Statusa[XD]/[XH]
N2bT14cA12d
%% %
CH 2DCN d 0.38 3.6–0.15 2.3–6.3
CH 2DCH 2CN (oop) t 0.05 – –
CH 2DCH 2CN (ip) n <0.024 – –
CH 3CHDCN t 0.05 – –
cis-... | 10.1051_0004-6361_201527268 | page_0009 |
A. Belloche et al.: Deuterated complex organic molecules in Sgr B2(N2)
obtain for methyl cyanide, the d euterated species of which
is securely identified in our ALMA spectrum of Sgr B2(N2)
(Sect. 6.1.1 ). Therefore, even if the di fference in deuterium
fractionation between methanol and methyl cyanide is a priori
surpris... | 10.1051_0004-6361_201527268 | page_0010 |
174901-3 P.-M. Lam and Y. Zhen J. Chem. Phys. 143, 174901 (2015)
g(f)+1
2Asin4α
r2+U(r)−sin 2α
2rM=0. (10)
Three equations (8)–(10) can be solved to obtain the remaining
three unknowns quantities α,r, and M.
In the high-force limit, Neukirch and Marko28have given
the solutions in closed form. Define a quantity Kas
K=
... | 10.1063_1.4934988 | page_0003 |
174901-4 P.-M. Lam and Y. Zhen J. Chem. Phys. 143, 174901 (2015)
FIG. 3. Comparison of experimental and theoretical torque as a function of
the applied force, for 50, 100, 200, and 500 mM salt (top to bottom). Circles
are experimental data. Full lines are our theoretical results using a better form
of the free energy. ... | 10.1063_1.4934988 | page_0004 |
174901-5 P.-M. Lam and Y. Zhen J. Chem. Phys. 143, 174901 (2015)
limit in which the chain lengths are infinitely long, do the two
ensembles yield identical results.
1D. Branzei and M. Foiani, Nat. Rev. Mol. Cell Biol. 11, 208 (2010).
2N. R. Cozzarelli, G. J. Cost, M. Nollmann, T. Viard, and J. E. Stray, Nat.
Rev. Mol. ... | 10.1063_1.4934988 | page_0005 |
J. Chem. Phys. 145, 114901 (2016); https://doi.org/10.1063/1.4962516 145, 114901
© 2016 Author(s).On the influence of the intermolecular
potential on the wetting properties of
water on silica surfaces
Cite as: J. Chem. Phys. 145, 114901 (2016); https://doi.org/10.1063/1.4962516
Submitted: 17 June 2016 • Accepted: 29 Au... | 10.1063_1.4962516 | page_0000 |
THE JOURNAL OF CHEMICAL PHYSICS 145, 114901 (2016)
On the influence of the intermolecular potential on the wetting properties
of water on silica surfaces
E. Pafong,a)J. Geske, and B. Drossel
Institut für Festkörperphysik, Technische Universität Darmstadt, Hochschulstr. 6, 64289 Darmstadt, Germany
(Received 17 June 2016... | 10.1063_1.4962516 | page_0001 |
114901-2 Pafong, Geske, and Drossel J. Chem. Phys. 145, 114901 (2016)
atoms has been added and the partial charges on each
silica atom are increased. We probed the performance of
both silica models by analyzing the wetting behaviour of
water on silica surfaces and comparing to the experimental
results.2,12,37–39
In the... | 10.1063_1.4962516 | page_0002 |
114901-3 Pafong, Geske, and Drossel J. Chem. Phys. 145, 114901 (2016)
FIG. 1. Top view of the two initial con-
figurations used in the MD simulations,
labelled in the subsequent figures with
“center” (a) and “surface” (b). Here the
hydration level is 30%. Si, O Si,H, H
are drawn in yellow, blue, and green,
while water ... | 10.1063_1.4962516 | page_0003 |
114901-4 Pafong, Geske, and Drossel J. Chem. Phys. 145, 114901 (2016)
FIG. 3. The water density at the pore surface, showing water molecules that are within a distance of 0.3 nm of the silica surface. For the GT surface ((e)-(h)), only
filling ratios of 30% and 40% are shown, since for larger filling ratios the surface... | 10.1063_1.4962516 | page_0004 |
114901-5 Pafong, Geske, and Drossel J. Chem. Phys. 145, 114901 (2016)
FIG. 4. Average number of hydrogen bonds per water molecule for water–silica ((a)-(b)) and water–water ((c)-(d)) contacts, for di fferent initial conditions and
filling ratios, as indicated in the legends. The results for the GT silica surface are gi... | 10.1063_1.4962516 | page_0005 |
114901-6 Pafong, Geske, and Drossel J. Chem. Phys. 145, 114901 (2016)
calculating numerically the volume and surface of the cut
droplet for over 1 ×106different combinations of the sphere
radius and the distance of the sphere center from the cylinder
axis. Then, we used this database to find for a given filling
ratio t... | 10.1063_1.4962516 | page_0006 |
A&A 641, A54 (2020)
Fig. 6. Abundances relative to H2of MF, DE, F, and EC (Table 10) as
a function of the total luminosity/mass ratio (see Sect. 6.3 for details)
for the sources of our sample. The linear best-fit to the data is shown for
each molecule.
luminosity and is not affected by any distance-induced observa-
tion... | 10.1051_0004-6361_202038212 | page_0011 |
A. Coletta et al.: Evolution of COMs in star-forming regions
Fig. 8. Average abundances relative to H2(with respective standard
errors) of MF, DE, F, and EC (different colours), as a function of the
evolutionary stage.
Balucani et al. (2015) present instead a gas-phase route able
to efficiently form MF from DE at low te... | 10.1051_0004-6361_202038212 | page_0012 |
A&A 641, A54 (2020)
(Blake et al. 1987). We also note that, given the increasing abun-
dance trend, molecular destruction routes seem to be less effi-
cient than formation/desorption mechanisms, especially at later
evolutionary stages (i.e. higher luminosities). However, destruc-
tion routes represent a less investigate... | 10.1051_0004-6361_202038212 | page_0013 |
A. Coletta et al.: Evolution of COMs in star-forming regions
Union’s Horizon 2020 research and innovation programme under the Marie
Skłodowska-Curie grant agreement No 664931. L.C. acknowledges support from
the Italian Ministero dell’Istruzione, Università e Ricerca through the grant
Progetti Premiali 2012 – iALMA (CUP... | 10.1051_0004-6361_202038212 | page_0014 |
A&A 641, A54 (2020)
López-Sepulcre, A., Balucani, N., Ceccarelli, C., et al. 2019, ACS Earth Space
Chem., 3, 2122
Manigand, S., Jørgensen, J. K., Calcutt, H., et al. 2020, A&A, 635, A48
Marcelino, N., Gerin, M., Cernicharo, J., et al. 2018, A&A, 620, A80
Martín, S., Martín-Pintado, J., Blanco-Sánchez, C., et al. 2019, ... | 10.1051_0004-6361_202038212 | page_0015 |
A. Coletta et al.: Evolution of COMs in star-forming regions
Appendix A: Sources without detections
In this appendix we list the 19 sources of the initial sample of
39 (see Sect. 2) which did not report detections of the COMs
analysed in this work (MF, DE, F, and EC).
Table A.1. Observed sources of the original sample ... | 10.1051_0004-6361_202038212 | page_0016 |
A&A 641, A54 (2020)
Appendix B: Selected fits
In this appendix we show, for each molecule, selected transitions
detected with the molecular line fitting procedure (see Sect. 4)
performed in different wavebands and sources.
Fig. B.1. Selected transitions of MF detected in different wavebands
and sources: ( a)0:9mm waveban... | 10.1051_0004-6361_202038212 | page_0017 |
A. Coletta et al.: Evolution of COMs in star-forming regions
Fig. B.3. Same as Figs. B.1–B.2, but for F: ( a)0:9mm waveband, source
W51; ( b)2mm, G31.41+0.31; ( c)3mm, G31.41+0.31.
Fig. B.4. Same as Figs. B.1–B.3, but for EC: ( a)0:9mm waveband,
source G10.47+0.03; ( b)2mm, G29.96-0.02; ( c)3mm, G31.41+0.31.
Appendix C... | 10.1051_0004-6361_202038212 | page_0018 |
A&A 641, A54 (2020)
C.1. Excitation temperatures
Table C.1 shows the excitation temperatures ( Tex, Sect. 5.3)
obtained for each molecule in the different wavebands assuming
LTE conditions.C.2. Systemic velocities
Table C.2 reports the best-fit LSR source velocities ( VLSR)
obtained for each molecule in the 2mm waveband... | 10.1051_0004-6361_202038212 | page_0019 |
A. Coletta et al.: Evolution of COMs in star-forming regions
Appendix D: Detected molecular transitions
In this appendix we list the most intense rotational transitions
(considering all the sources) detected with MADCUBA (see
Sect. 4) for each molecule in each waveband.
Table D.1. Selection of the transitions which wer... | 10.1051_0004-6361_202038212 | page_0020 |
compounds that decrease AR expression have been reported to decrease AR by inhibiting its
synthesis ( 76, 77).
As a parallel strategy to rationally design a SARD, we appended the adamantyl moiety to
the AR agonist RU59063 ( 70). Gratifyingly, we found that this addition switched the agonist
into a pure antagonist ca... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0008 |
calcineurin function in the malarial parasite Plasmodium berghei (85). The use of CRISPR/
Cas9 to introduce AID into the endogenous genomic locus of the gene of interest for
conditional protein depletion in Caenorhabditis elegans has proved to be particularly useful
(86). Zhang et al. ( 86) first confirmed that the... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0009 |
A final system based on PROTACs and a fusion protein-binding domain was highlighted
alongside the cereblon-based PROTACs against BRD4 (see above). This system uses a
FK506 binding protein 12 (FKBP12) fusion protein and its high-affinity ligand conjugated
to Thalidomide. This compound was also able to degrade free FK... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0010 |
If no known ligand for the POI exists, then small molecule–based protein degradation
systems using protein fusions are available. Because the POI is likely available as a fusion to
the HaloTag protein, HaloPROTACs can provide a robust tool for specific degradation.
Alternatively, AID also provides very rapid degrada... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0011 |
CRL cullin ring E3 ligase
IMiD immunomodulatory drug or cereblon binding molecule
PROTAC proteolysis targeting chimera
AR androgen receptor
SERD selective estrogen receptor downregulator
ERα estrogen receptor α
CK1α casein kinase 1 α
BRD4 bromodomain protein 4
SARD selective androgen receptor downregulator
AID auxin-in... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0012 |
14. Govek SP, Nagasawa JY , Douglas KL, Lai AG, Kahraman M, et al. Optimization of an indazole
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Figure 1.
Compounds that degrade their respective targets without requiring any genetic manipulation.
The substrate binding portion is highlighted in yellow, whereas purple dictates parts of the
compound that induce target protein degradation. ( a) ARN-810, a bioavailable SERD that
causes degradation upon rearrange... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0019 |
Author Manuscript Author Manuscript Author Manuscript Author ManuscriptBondeson and Crews Page 21Table 1
Summary of small-molecule-inducible degrons
Fusion tag Compounds N or C terminal? Mass of tag DC50aDMaxbt1/2cReference(s)
HaloTag HaloPROTAC3 Both 37 kDa 19 nM 90% 4–8 h 91
HaloTag Bestatin 1b Both 37 kDa 1 μM 39% 1... | cfa9da281941a329299bc535ce3bb85c2ee70727 | page_0020 |
letters to nature
970 NATURE |VOL 406 |31 AUGUST 2000 |www.nature.comindication that blinking does not occur on the timescales of interest
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absorption have demonstrated the existence of discrete QD
resonances8. However, just as the observatio... | 5a62ad4f00e46cc072cc6f5b2c0e14fa1207aba4 | page_0000 |
letters to nature
NATURE |VOL 406 |31 AUGUST 2000 |www.nature.com 971the orange adducts by reversible bond formation and cleavage10.
W e therefore expect that these crystalline materials will ®nd
applications for gas storage devices and as opto-electronic
switches11,12.
Chemical transformations that occur in crystallin... | 5a62ad4f00e46cc072cc6f5b2c0e14fa1207aba4 | page_0001 |
letters to nature
972 NATURE |VOL 406 |31 AUGUST 2000 |www.nature.comrestricted to enzymes and other materials with an `open' (that is,
porous)17structure with large cavities (for example, zeolites)18±20.A
versatile way of overcoming this problem relies on crystal
engineering21, whose intention is the design and proces... | 5a62ad4f00e46cc072cc6f5b2c0e14fa1207aba4 | page_0002 |
letters to nature
NATURE |VOL 406 |31 AUGUST 2000 |www.nature.com 973signals is dependent on the atmospheric constitution and thus
demonstrates the potential of this material as a crystalline switch
(Fig. 3). The gas ®xation process of crystalline 1(`off' position) in a
steady atmosphere of SO 2is best approximated by ... | 5a62ad4f00e46cc072cc6f5b2c0e14fa1207aba4 | page_0003 |
letters to nature
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University of Groningen
Light-Controlled Conductance Switching of Ordered Metal-Molecule-Metal Devices
Molen, Sense Jan van der; Liao, Jianhui; Kudernac, Tibor; Agustsson, Jon S.; Bernard,
Laetitia; Calame, Michel; Wees, Bart J. van; Feringa, Ben L.; Schönenberger, Christian
Published in:
Nano Letters
DOI:
10.10... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0000 |
1 Supporting Information
Light-controlled conductance switching of ordered metal-molecule- metal devices
S.J. van der Molen *,1,2,3 , J. Liao 1, T. Kudernac 4, J.S. Agustsson 1, L. Bernard 1, M.
Calame 1, B.J. van Wees 2, B.L. Feringa 4, C. Schönenberger1
1: Department of Physics, University of Basel, Klin... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0001 |
2 1. Details on sample preparation and experimental techniques
a) Sample preparation: We synthesize diarylethene molecules with two acetyl-protected
thiol endgroups connected to the central switching unit via a metap henyl spacer (Fig. 1a
of the manuscript) [27,28]. Two-dimensional, hexagonally ordered arrays of... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0002 |
3
2. Optical spectra of diarylethene molecules in solution
In Fig. S1, we show optical absorption spectra for thiolated me taphenyl-substituted
diarylethene molecules in dry toluene. Figure S1a, displays the spectra for molecules in
which the thiol group is ‘protected‘ by an acetyl group. The cl osed, ‘on’-stat... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0003 |
4 3. Experiments in ambient conditions
Experiments in air at room temperature show reversible swit ching. However, switching is
less pronounced than in an argon flow cell and the devices deteriorat e faster. After 1 to 2
switching cycles the samples break down. An example is shown i n Fig. S2, for a device
of simi... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0004 |
5 4. Photodegradation due to long UV-illumination in Ar flow cell
In Figure S3, we show an illumination experiment on a nanoparticl e network with ‘on’-
state diarylethene bridges. The sample is similar to ‘samp le 1’ in Figure 3 of the
manuscript (length: 0.25 mm, width: 6.3 mm). The experiment is done i n an argon... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0005 |
6 5. Illumination of octanemonothiol-covered nanoparticle networks
We performed reference experiments on octanemonothiol-covered nanopartic le networks.
These are samples as prepared before molecular bridging, of similar dimensions as
‘sample 2’ considered in Figure 2 of the main manuscript (lengt h: 10 µm, width:... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0006 |
7 6. Illumination of nanoparticle networks bridged by OPV-dithiol molecu les
We performed reference experiments on nanoparticle networks, i n which (oligo(=3)-
phenylenevinylene-dithiol molecules (OPV) have formed bridges bet ween neighbouring
nanoparticles (see Fig. S5a). These samples are of similar dimensions as... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0007 |
8 7. Scanning electron microscopy
In Fig. S6, we show a scanning electron microscopy (SEM) ima ge of ‘sample 1’ taken
after the experiment shown in Figure 3 of the manuscript. The nano particle structure is
still intact. Moreover, neither visible nor UV-illumination has c hanged the nanoparticle
lattice. Hence, st... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0008 |
9 8. Percolation
Here, we employ percolation theory to model the conductance for ‘s ample 2’ after
sequential visible and UV illumination (see Fig. 2 of manuscript ). Our calculation is
based on the general effective medium equation, which has proven to give a successful
relation between conductance, G, and the pe... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0009 |
10 References (numbering is the same as in the main manuscript)
[27] Kudernac, T., de Jong, J.J., van Esch, J., Feringa, B.L., Dulic, D., van der Molen,
S.J., van Wees, B.J. Mol. Cryst Liq. Cryst . 430 , 205-210 (2005);
[28] Kudernac, T., van der Molen, S.J., van Wees, B.J., Feringa, B.L.
Chem. Comm. 359... | 184873c219ecbb27e85e30a1aeee4a42757b1e52 | page_0010 |
BioMed Central
Page 1 of 1
(page number not for citation purposes)BMC Systems Biology
Open Access Poster presentation
Molecules for memory: modelling CaMKII
Melanie Stefan* and Nicolas Le Novere
Address: EMBL – European Bioinformatics Inst itute (EBI), Hinxton, Cambridge, CB10 1SD, UK
Email: Melanie Stefan* - mstefan@e... | b3c74a438f16a267df78ff34834a8c465b29db3b | page_0000 |
molecules
Review
Continuous Flow Photochemistry for the Preparation
of Bioactive Molecules
Mara Di Filippo, Cormac Bracken and Marcus Baumann *
School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland;
mara.difilippo@ucdconnect.ie (M.D.F.); cormac.bracken@ucdconnect.ie (C.B.)
*Cor... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0000 |
Molecules 2020 ,25, 356 2 of 13
both temperature and energy input. Finally, continuous flow processing allows for simple reaction
scale-up of the resulting photoreaction without alteration of reaction parameters and the short residence
times within the photoreactor reduce the likelihood of decomposition of substrate or ... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0001 |
Molecules 2020 ,25, 356 3 of 13
Figure 1. Images of a falling film reactor plate (reproduced with permission from [ 25]) and the Corning
G3 photoreactor [26].
Another approach to realize such photooxygenation reactions in a continuous manner was
reported by Pergantis and Vassilikogiannakis, who developed a nebulizer-bas... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0002 |
Molecules 2020 ,25, 356 4 of 13
Figure 4. Representations of the vortex fluidic device. ( A) A schematic of the vortex fluidic device; ( B)
A photograph of the vortex fluidic device; (reproduced with permission from [30]).
In order to enable large scale generation of desired photo-products, Booker-Milburn and co-workers
r... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0003 |
Molecules 2020 ,25, 356 5 of 13
Figure 6. Images of the Vapourtec high-power LED reactor and Uniqsis’s PhotoSyn reactor.
As can be seen from this compilation of continuous photo-reactors, numerous reactor types
have been developed, and their successful application to di erent types of chemical reactions
(i.e., cycload... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0004 |
Molecules 2020 ,25, 356 6 of 13
works of Cannizzaro, Paterno and Ciamician); however, the heterogeneity of solar light ( 5% UV , 43%
visible, 52% IR), together with inconsistent photon flux (seasons, cloud coverage, day /night pattern
and geographical impact), make this approach challenging. In order to mitigate thes... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0005 |
Molecules 2020 ,25, 356 7 of 13
Figure 8. Structures of complex bioactive molecules featuring flow photochemistry key steps.
Other examples include the photochemical preparation of the anti-inflammatory drug ibuprofen
by a photo-Favorskii rearrangement, which highlights an attractive and atom-economical continuous
approa... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0006 |
Molecules 2020 ,25, 356 8 of 13
Figure 10. Continuous photosynthesis of pyocyanin (reproduced with permission from [61]).
In addition to natural products and their analogs, several recent reports detail the use of
continuous photochemical methods for the generation of drug-like heterocyclic sca olds that hold
interest... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0007 |
Molecules 2020 ,25, 356 9 of 13
5. Remaining Challenges for E ectively Integrating Photoreactions within Multistep Sequences
The previous section outlined the breath of applications in which continuous photochemical
transformations were e ectively exploited to bring about the generation of bioactives in the form
of d... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0008 |
Molecules 2020 ,25, 356 10 of 13
In addition, many publications outline collaborative e orts between academics and their industry-based
colleagues, again highlighting the synergy of such joint projects. It can be anticipated that this
development will render further applications of continuous light-driven reactions, e... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0009 |
Molecules 2020 ,25, 356 11 of 13
19. Staveness, D.; Bosque, I.; Stephenson, C.R.J. Free Radical Chemistry Enabled by Visible Light-Induced
Electron Transfer. Acc. Chem. Res. 2016 ,49, 2295–2306. [CrossRef]
20. Bogdan, A.R.; Organ, M.G. Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective.
InFlow C... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0010 |
Molecules 2020 ,25, 356 12 of 13
42. Fukuyama, T.; Hino, Y.; Kamata, N.; Ryu, I. Quick execution of [2 +2] type photochemical cycloaddition
reaction by continuous flow system using a glass-made microreactor. Chem. Lett. 2004 ,33, 1430–1431.
[CrossRef]
43. Cambie, D.; Noël, T. Solar Photochemistry in flow. Top. Curr. Chem... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0011 |
Molecules 2020 ,25, 356 13 of 13
66. Strauss, F.J.; Cantillo, D.; Guerra, J.; Kappe, C.O. A laboratory-scale continuous flow chlorine generator for
organic synthesis. React. Chem. Eng. 2016 ,1, 472–476. [CrossRef]
67. Baker, J.R.; Gilbert, J.; Paula, S.; Zhu, X.; Sako , J.A.; McCluskey, A. Dichlorophenylacrylonitriles ... | e3b3828c6c32f511c9b5fa9c4f08188c1746e1a9 | page_0012 |
IAGG 2017 World Congressa Chinese city. Frailty was assessed using the FRAIL Scale.
A healthy lifestyle accumulation index was constructed using
measures on physical activity, daily living habits and social
participation. Data on ADL, IADL, depression, cognition
and socio-demographics were also collected. The preva... | d92c345558961e8290e78a7ae37fe235ab540a8a | page_0000 |
IIAGG 2017 World Congressat baseline than the other groups. Poisson regression mod -
els found that frailty counts increased with diabetes (IRR
1.19, 95%CI 1.09–1.29 and IRR 1.17, 95% CI 1.10–1.24
respectively) and pain (IRR 1.19, 95% CI1.09-1.29 and IRR
1.18, 95% CI 1.16–1.41 respectively) and decreased with
churc... | d92c345558961e8290e78a7ae37fe235ab540a8a | page_0001 |
Creation of a low-entropy quantum gas of polar molecules in an optical lattice
Steven A. Moses, Jacob P. Covey, Matthew T. Miecnikowski, Bo Yan,Bryce Gadway,yJun Yez, and Deborah S. Jinz
JILA, National Institute of Standards and Technology and the University of Colorado,
and the Department of Physics, University of Co... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0000 |
2
FIG. 1. Quantum synthesis for creating polar molecules. Left:
strategy for realizing high lling of molecules in a 3D lattice.
We load K (blue) and Rb (red) atoms into a 3D optical lat-
tice, with many more K atoms than Rb atoms. In the center
of the lattice where the two atom clouds overlap, we realize a
Rb Mott ins... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0001 |
3
A
B C
F
E
D−2 −1 0 1 200.10.20.30.4
Quasimomentum (¯ hk)OD
FIG. 2. (A)The super
uid-Mott insulator transition for Rb. The three images of Rb were taken after 8 ms of expansion from
the lattice, where the nal lattice depth is 12, 17, and 22 ERb
Rfrom left to right. The optical depth (OD) for each image is
indicated... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0002 |
4
00.20.40.60.81fwith K/fRb
−300−200−100 0100 20000.20.40.60.81
Scattering length ( a0)BEC fractionA
BC
00.20.40.60.81Peak filling
0.20.30.40.50.60.7
T/TF
0.20.30.40.50.60.7
0 10 20 3000.20.40.60.81
K number (104)12 51020 50100012345
Rb number (103)Peak filling
FIG. 3. (A)Measured Rb MI peak lling fTF(blue points) vs. R... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0003 |
5
540 550 560−600−400−2000200400
|9/2,−9/2/angbracketright
|9/2,−7/2/angbracketright
B (Gauss)Scattering length ( a0)
540 550 560
B (Gauss)540 550 560
B (Gauss)A
B C
1 3510 2030508015000.20.40.60.81
Rb number (103)NKRb*/NRb
FIG. 4. (A) The interspecies Feshbach resonance. The atoms are loaded into the lattice at a= 0. ... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0004 |
6
to their ro-vibrational ground state [5]. The typical ef-
ciency of this transfer is 89(4)%. Once the molecules
are in the ground state, we apply resonant light pulses
to remove all unpaired atoms from the lattice. This
atom removal is essential since the molecule lifetime
in the lattice without atom removal is only... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0005 |
7
[11] K. R. A. Hazzard, S. R. Manmana, M. Foss-Feig, and
A. M. Rey, Phys. Rev. Lett. 110, 075301 (2013).
[12] B. Yan, S. A. Moses, B. Gadway, J. P. Covey, K. R. A.
Hazzard, A. M. Rey, D. S. Jin, and J. Ye, Nature 501,
521 (2013).
[13] K. R. A. Hazzard, B. Gadway, M. Foss-Feig, B. Yan,
S. A. Moses, J. P. Covey, N. Y. Y... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0006 |
8
Molecule production and detection
Similar to previous work [5, 8, 9], we create weakly
bound Feshbach molecules by magneto-association, in
which the magnetic eld is swept from above the reso-
nance to below the resonance. In the experiments re-
ported here, the sweep takes 5 ms, starts at 563 G, and
ends at 545.6 G.... | bf565c21c1851f395772ed9d29d23bb4c5a53360 | page_0007 |
INFECTION ANDIMMUNITY, Aug.1982,p.601-608 Vol.37,No.2
0019-9567/821080601-08$02.00/0
Alteration ofCell-Mediated Immunity toListeria
monocytogenes inProtein-Malnourished MiceTreated with
Thymosin Fraction Vt
THOMAS M.PETRO,* GRACECHIEN, ANDRONALD R.WATSON
Department ofFoodsandNutrition, PurdueUniversity, WestLafayette, ... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0000 |
602PETRO, CHIEN, ANDWATSON
TABLE 1.AINsemipurified rat-mouse dieta
%oftotaldietfor:ComponentControl Lowprotein
Caseinhighnitrogen 20.0 4.0
DL-Methionine 0.3 0.3
Cornstarch 15.0 15.0
Sucrose 50.0 66.0
Fiber-Celufil 5.0 5.0
Cornoil 5.0 5.0
AINmineralmix 3.5 3.5
AINvitaminmix 1.0 1.0
Cholinebitartrate 0.2 0.2
aU.S.Biochem... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0001 |
PROTEIN MALNUTRITION ANDTHYMOSIN TREATMENT 603
TABLE 2.EffectofMPDdietonresistance of
youngmicetoinfection withL.monocytogenes
Dietary Log1oCFUperliverandspleenatdayprotein afterinfection'level(%) 3b 7c 7d
20 5.29±0.223.38±0.473.38±0.47
45.23±0.194.11±0.624.59±0.72
aSix-week-old BALB/c micewerefedeithera20or
4%caseindi... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0002 |
604PETRO, CHIEN, ANDWATSON
6.0
5.0
iI*4.0
0
5
93.0
2.0
1.020%ProteinDiet_KIContro nGMMiceThymosinInjected
4%ProteinDiet_CCControlOMiceThymosinInjected
pgThymosinInjeced
FIG.2.CFU(standard errorindicated bybars)in
liversat7daysafterinfection ofsevenmiceintraperi-
toneally with1x104L.monocytogenes cells.Num-
bersinparent... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0003 |
PROTEIN MALNUTRITION ANDTHYMOSIN TREATMENT 605
; a% prw.in oi(DMiceThms Injectd
g~~~~~4P6o 4#Dist CBOWmoht e DI.K~CMice ThWInjected
j5-
3m400 MO0 700
gThyrnosn Injected
FIG.4.Counts perminute(standard errorindicat-
edbybars)of[3H]thymidine in2.5x105PHA-
stimulated spleencellsfrommiceinfected intraperito-
neally7daysea... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0004 |
606PETRO, CHIEN, ANDWATSON
TABLE 4.Effectofthymosin fraction V(Thy)onresponsiveness ofspleencellsfromcontrolormoderately
protein-malnourished BALB/c micetoPHA'
cpmof[3HJthymidine incorporated"
Levelof Treatment 2.5x105cells 5.0x105cells
dietary type______________ __________________protein WithPHA Without WithPHA Withou... | 6af22847549485aaa772d087f74d54cd9382aee3 | page_0005 |
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