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query stringlengths 1 13.4k | pos stringlengths 1 61k | neg stringlengths 1 63.9k | query_lang stringclasses 147
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Context.—Primary mitochondrial dysfunction is one of the most common causes of inherited disorders predominantly involving the neuromuscular system. Advances in the molecular study of mitochondrial DNA have changed our vision and our approach to primary mitochondrial disorders. Many of the mitochondrial disorders are c... | Research in the last decade has revolutionized the way in which we view mitochondria. Mitochondria are no longer viewed solely as cellular powerhouses; rather, mitochondria are now understood to be vibrant, mobile structures, constantly undergoing fusion and fission, and engaging in intimate interactions with other cel... | Sequences in overall DNA which hybridize with ribosomal RNA are more abundant in adults than in third-instar larvae of D. melanogaster. | eng_Latn | 200 |
Thiazolidinediones are synthetic agonists for the transcription factor peroxisome proliferator-activated receptor γ (PPARγ) and are therapeutically used as insulin sensitizers. Besides therapeutical benefits, potential side effects such as the induction of cell death by thiazolidinediones deserve consideration. Althoug... | Background ::: ::: Troglitazone (TRO), a thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ agonist, was recently withdrawn from the market because of rare but serious hepatotoxicity. Previous studies investigating the cytotoxicity of TRO in cultured rat hepatocytes have conjectured about the role of ... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 201 |
Cardiac ischemia and reperfusion promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. Mitochondrial aldehyde dehydrogenase 2 is emerging as a key cardioprotective enzyme for its central role in the detoxification of reactive aldehydes. Mitochondrial aldehyde dehydrogena... | C1 compounds participate in various metabolic processes and regulations including DNA methylation. Formaldehyde (FA), a product of methyl group oxidation, is highly cytotoxic. In the cell, there are two pathways of its utilization: assimilation and oxidation. Formaldehyde displays cytotoxicity, and therefore its oxidat... | We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wil... | eng_Latn | 202 |
BKCa channels, originally discovered in Drosophila melanogaster as slowpoke (slo), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BKCa channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role... | Daxx-like protein (DLP), the Drosophila homolog of Daxx, binds Drosophila melanogaster p53 (Dmp53) through its C-terminal region. We generated DLP mutants and found that although DLP expression is developmentally regulated, it is not essential for the execution of the developmental program. The effects DLP mutations sh... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 203 |
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are degraded. Under stress conditions, such as starvation or oxidative stress, autophagy is upre... | Autophagy is a catabolic mechanism, allowing the degradation of cytoplasmic content via lysosomal activity. Several forms of autophagy are described in mammals. Macroautophagy leads to integration of cytoplasmic portions into vesicles named autophagosomes that ultimately fuse with lysosomes. Chaperone-mediated autophag... | Autophagy is a major cellular recycling process that delivers cellular material and entire organelles to lysosomes for degradation, in a selective or non-selective manner. This process is essential for the maintenance of cellular energy levels, components and metabolites, as well as the elimination of cellular molecula... | eng_Latn | 204 |
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. Metformin, a widely known anti-diabetic drug, used for patients with type 2 diabetes mellitus, is also claimed to be useful in treatment of NAFLD. However, both the clinical efficacy and the putative mechanisms underlying the clini... | There is a growing body of evidence that altered functioning of apoE may aggravate cellular energy homeostasis and stress response, leading to oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress and inflammation, leading to hypercholesterolemia, dyslipidemia, liver steatosis and neurodegenera... | Combustion modes in locally stratified dual-fuel (DF) mixtures are numerically investigated for methanol/n-dodecane blends under engine-relevant pressures. In the studied constant-volume numerical setup, methanol acts as a background low-reactivity fuel (LRF) while n-dodecane serves as high-reactivity fuel (HRF), contr... | eng_Latn | 205 |
Ischemic conditioning is an intrinsic protective mechanism in which repeated short episodes of reversible ischemia protects the tissue and increases its tolerance against a subsequent longer period of ischemia (index ischemia). Bradykinin is a physiologically and pharmacologically active peptide of the kallikrein-kinin... | Over the past 30years the mitochondrial permeability transition - the permeabilization of the inner mitochondrial membrane due to the opening of a wide pore - has progressed from being considered a curious artifact induced in isolated mitochondria by Ca(2+) and phosphate to a key cell-death-inducing process in several ... | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 206 |
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B... | When considering which components of the cell are the most critical to function and physiology, we naturally focus on the nucleus, the mitochondria that regulate energy and apoptotic signaling, or other organelles such as the endoplasmic reticulum, Golgi, ribosomes, etc. Few people will suggest that the membrane is the... | ABSTRACTUNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system... | eng_Latn | 207 |
Friedreich's ataxia (FRDA) is a hereditary neurodegenerative disease that frequently culminates in cardiac failure at an early age. FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunctio... | Friedreich’s ataxia is an autosomal recessive disorder characterized by impaired mitochondrial function, resulting in oxidative stress. In this study, we aimed at evaluating whether tocotrienol, a ... | Fractal like morphology is a very interesting feature during electrodeposition of metals and shows pattern transition with changes in deposition conditions. In this article, we have explained the thermal effects in the two dimensional DLA morphology on the basis of thermal free energy and another free energy barrier re... | eng_Latn | 208 |
Mitochondrial Ca2+ accumulation and the formation of reactive oxygen species are processes dependent on the electron transport system. The production of superoxide by respiring rat heart mitochondria was decreased by either chelating extramitochondrial Ca2+ with EGTA or by blocking mitochondrial Ca2+ uptake with ruthen... | Adriamycin (doxorubicin) is a potent and broad-spectrum antineoplastic agent, the clinical utility of which is limited by the development of a cumulative and irreversible cardiomyopathy. Although the drug affects numerous structures in different cell types, the mitochondrion appears to a principal subcellular target fo... | ABSTRACTUNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system... | eng_Latn | 209 |
Background A possible relationship between mitochondrial haplogroups and psychiatric diseases (e.g. schizophrenia and bipolar disorder) has been postulated, but data regarding depression is still limited. We investigated whether any mitochondrial haplogroup carried a significant higher risk of depressive symptoms in a ... | The human mitochondrial genome is very small and economically packed; the expression of the whole genome is essential for the maintenance of mitochondrial bioenergetic function. Mutation occurs at a much higher rate in the mitochondrial DNA (mtDNA) than in chromosomal DNA. Transient heteroplasmy of mtDNA occurs after a... | For transformer cooling applications, magnetic particles need to be dispersed in carrier fluids with high colloidal stability for a long period without significant degradation. However, stability of the suspension, especially the long term colloidal stability is a crucial factor for the applications in power transforme... | eng_Latn | 210 |
Systemic inflammatory response syndrome (SIRS) development is accompanied by mitochondrial dysfunction and excessive ROS production. Mitochondrial dysfunctions also occur in many SIRS-related diseases and may be critical for their pathogenesis; therefore, a use of mitochondria-targeted drugs is a promising trend in SIR... | Objective: Mitochondrial impairment in the skeletal muscle contributes to useless of limbs in spleen qi deficiency; however the genesis of such impairment is not clear. Herein, PTEN-induced putative kinase 1 (PINK1)-Parkin pathway and mitophagy were studied to explore the machinery of mitochondrial impairment. Methods:... | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 211 |
The cellular and molecular basis of brain stem death remains an enigma. As the origin of a “life-and-death” signal that reflects the progression toward brain stem death, the rostral ventrolateral medulla (RVLM) is a suitable neural substrate for mechanistic delineation of this phenomenon. Here, we evaluated the hypothe... | The central nervous system plays a critical role in the normal control of arterial blood pressure and in its elevation in virtually all forms of hypertension. Mitochondrial dysfunction has been increasingly associated with the development of hypertension. Therefore, we examined whether mitochondrial dysfunction occurs ... | We report enhancement of the mechanical stability of graphene through a one-step method to disperse gold nanoparticles on the pristine graphene without any added agent. | eng_Latn | 212 |
The role of mitochondria in haematopoietic stem-cell maintenance has not been examined in detail; here mitofusin 2, which modulates mitochondrial fusion and tethering of endoplasmic reticulum to the mitochondria, is shown to be necessary for the maintenance of haematopoietic stem cells with extensive lymphoid potential... | Mutations in the mitochondrial fusion gene Mfn2 cause the human neurodegenerative disease Charcot-Marie-Tooth type 2A. However, the cellular basis underlying this relationship is poorly understood. By removing Mfn2 from the cerebellum, we established a model for neurodegeneration caused by loss of mitochondrial fusion.... | This paper describes visual route following for a cliff-climbing, tethered mobile robot for the purpose of autonomously traversing extreme terrain in the presence of obstacles. When the robot's tether contacts an obstacle, an intermediate anchor is formed. In order to detach from intermediate anchors and avoid entangle... | eng_Latn | 213 |
Saccharomyces cerevisiae cells lacking the yeast frataxin homologue (Δyfh1) accumulate iron in the mitochondria in the form of nanoparticles of ferric phosphate. The phosphate content of Δyfh1 mitochondria was higher than that of wild-type mitochondria, but the proportion of mitochondrial phosphate that was soluble was... | BACKGROUND ::: Protein aggregation and its pathological effects are the major cause of several neurodegenerative diseases. In Huntington's disease an elongated stretch of polyglutamines within the protein Huntingtin leads to increased aggregation propensity. This induces cellular defects, culminating in neuronal loss, ... | With the present rates of iron ore consumption, currently unusable, high-phosphorus iron ore deposits are likely to be the iron ores of the future as higher-grade iron ore reserves are depleted. Consequently, the design and timely development of environmentally-benign processes for the simultaneous beneficiation of hig... | eng_Latn | 214 |
Oxidative stress is one of the major causes of aging considered at both the cellular and organismal levels. There is evidence that this agent may also constitute a common element connecting the aging of cells of higher organisms with a similar process occurring in eukaryotic and prokaryotic unicellulars. The aim of thi... | Skin aging is a complex process which involves all the layers of the epidermis and dermis. In order to slow skin aging, methods are researched which would strengthen and protect skin stem cells. Science is in search of the right method to stimulate the proliferation of epidermal stem cells. Plant stem cells show outsta... | All organisms must display a certain degree of environmental adaptability to survive and reproduce. Growth and reproduction are metabolically expensive and carry other costs that contribute to aging. Therefore, animals have developed physiologic strategies to assess the harshness of the environment before devoting reso... | eng_Latn | 215 |
When endothelial cells from different vascular beds are grown in culture they show a limited capacity to divide, eventually entering into a permanent and phenotypically distinctive non-dividing state referred to as ‘replicative senescence’. Replicative senescence is thought to result from progressive shortening of telo... | In a previous study, we demonstrated that endothelial microvesicles (eMVs) have a well-developed enzymatic team involved in reactive oxygen species detoxification. In the present paper, we demonstrate that eMVs can synthesize the reducing power (NAD(P)H) that nourishes this enzymatic team, especially those eMVs derived... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 216 |
Publisher Summary This chapter reviews the literature on the application of organ culture to the study of vitamins and hormones. The organ culture technique enables part of a complicated problem to be isolated from the general confusion of the body so that it may be studied under controlled, simplified-and yet abnormal... | In the 50 years since we described cell death as 'programmed,' we have come far, thanks to the efforts of many brilliant researchers, and we now understand the mechanics, the biochemistry, and the genetics of many of the ways in which cells can die. This knowledge gives us the resources to alter the fates of many cells... | Age serves as a basis for assigning status and regulating social interaction across all societies. Members of the cultural group socialize new members into the rules and roles that are associated w... | eng_Latn | 217 |
We used Au nanoparticles (Au-NPs) as a model for studying particle-specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, Caenorhabditis elegans . Global genome expression for nematodes exposed to 4-nm citrate-coated Au-NPs at the LC(10) level (5.9 mg·L(... | In Caenorhabditis elegans, heterochronic genes constitute a developmental timer that specifies temporal cell fate selection. The heterochronic gene lin-42 is the C. elegans homolog of Drosophila and mammalian period, key regulators of circadian rhythms, which specify changes in behavior and physiology over a 24 hr day/... | We report enhancement of the mechanical stability of graphene through a one-step method to disperse gold nanoparticles on the pristine graphene without any added agent. | eng_Latn | 218 |
The transformation of 2,3-oxidosqualene to lanosterol is catalyzed by a microsomal enzyme (cyclase) which can be obtained in soluble and partially purified form by treatment of liver microsomes with deoxycholate as previously shown. The catalytic and physical properties of the soluble enzyme are determined by ionic str... | Parkinson's disease (PD) is a neurodegenerative disorder marked by the selective degeneration of dopaminergic neurons in the nigrostriatal pathway. Several lines of evidence indicate that mitochondrial dysfunction contributes to its etiology. Other studies have suggested that alterations in sterol homeostasis correlate... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 219 |
Chronic alcoholism causes a variety of ultrastructural, biochemical and functional alterations in the myocardium, but the underlying mechanisms are not well understood. Molecular changes that developed in the left ventricles of rats fed for 1 to 24 weeks on liquid diets containing ethanol as 36% of total calories were ... | AIMS ::: Alcoholic cardiomyopathy (ACM) presents as decreased myocardial contractility, arrhythmias and secondary non-ischemic dilated cardiomyopathy leading to heart failure. Mitochondrial dysfunction is known to have a significant role in the development and complications of ACM. This study investigated if chronic et... | We describe a method which allows isolation of deletions within hybrid plasmids. It is based on the fact that the tetracycline resistance (Tc R ) gene of pBR322 can be inactivated by inserting foreign DNA into its Hin dIII site, and that the easily selectable Tc R mutants of such plasmids are generally (>90%) due to de... | eng_Latn | 220 |
Periodontitis, the most prevalent chronic inflammatory disease, has been related to cardiovascular diseases. Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. The aim of this research was to study the role of autophagy in peripheral blo... | Experiments with isolated mitochondria have established that these organelles are pivotal intracellular sources of superoxide in a variety of pathophysiological conditions. Recently, a novel fluoroprobe MitoSOX Red was introduced for selective detection of superoxide in the mitochondria of live cells and was validated ... | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 221 |
Alpha synuclein protein may play an important role in familial and sporadic Parkinson's disease pathology. We have induced G209A mutant or wild-type alpha-synuclein expression in stable HEK293 cell models to determine if this influences markers of oxidative stress and damage under normal conditions or in the presence o... | Alpha-synuclein is the major protein component of Lewy bodies, a cardinal pathological feature of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be able to intercalate into membranes via formation of an alpha-helical structure at its N-terminal end. Recent in vitro studies from various labora... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 222 |
Oxidative stress has been suggested to contribute to the development of diabetic nephropathy. Manganese superoxide dismutase (MnSOD) protects the cells from oxidative damage by scavenging free radi ... | This study characterizes mitochondria isolated from livers of Sod2(-/+) and Sod2(+/+) mice. A 50% decrease in manganese superoxide dismutase (MnSOD) activity was observed in mitochondria isolated from Sod2(-/+) mice compared with Sod2(+/+) mice, with no change in the activities of either glutathione peroxidase or coppe... | This study characterizes mitochondria isolated from livers of Sod2(-/+) and Sod2(+/+) mice. A 50% decrease in manganese superoxide dismutase (MnSOD) activity was observed in mitochondria isolated from Sod2(-/+) mice compared with Sod2(+/+) mice, with no change in the activities of either glutathione peroxidase or coppe... | eng_Latn | 223 |
Large-conductance Ca 2+ -activated K + channels (BK channels) are widely expressed throughout the vertebrate nervous system, and are involved in the regulation of neurotransmitter release and neuronal excitability. Here, the neuroprotective effects of NS11021, a selective and chemically unrelated BK channel activator, ... | Mitochondria are as highly specialized organelles and masters of the cellular energy metabolism in a constant and dynamic interplay with their cellular environment, providing adenosine triphosphate, buffering Ca2+ and fundamentally contributing to various signaling pathways. Hence, such broad field of action within euk... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 224 |
Numerous human pathologies result from unrepaired oxidative DNA damage. Base excision repair (BER) is responsible for the repair of oxidative DNA damage that occurs in both nuclei and mitochondria. Despite the importance of BER in maintaining genomic stability, knowledge concerning the regulation of this evolutionarily... | Reactive oxygen species (ROS) are generated as by-products of respiration and are used as signal transducing intermediates in out-in signaling pathways. ROS are also generated during inflammatory responses and it has been shown that hydrogen peroxide may trigger activation of B-lymphocytes, similar to cross-linking of ... | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 225 |
Although valproic acid (VPA) a proven anticonvulsant agent thought to have relatively few side-effects VPA has been referred as the third most common xenobiotic suspected of causing death due to liver injury. In this study the cellular pathways involved in VPA hepatotoxicity were investigated in isolated rat hepatocyte... | Palladium (Pd) accumulates in many organs and renders many deleterious effects. Although the Pd toxicity has been documented, the precise mechanism of Pd toxicity still needs to be elucidated. In the current research, a hepatotoxicity mechanism of Pd has been investigated. Our findings clearly indicate that Pd induces ... | Valproic acid (VPA) is a widely used antiepileptic drug to treat epilepsy and psychiatric disorders, but potentially causes idiosyncratic liver injury. Alpers-Huttenlocher syndrome (AHS), a neurometabolic disorder caused by mutations in mitochondrial DNA polymerase gamma (POLG), is associated with an increased risk of ... | eng_Latn | 226 |
A degeneration-like order for modules | Degenerations and other partial orders on the space of representations of algebras | Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals | eng_Latn | 227 |
Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells | The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic T-cells and untransformed human peripheral blood T-cells, particularly after treatment with anti-le... | A recurring problem in forensic medicine is the need to fix the time of death within the limits of probability. Errors in overestimating and underestimating the post-mortem interval based on body cooling is common. Post-mortem biochemistry has become a potent additional procedure in forensic death investigation. Howeve... | eng_Latn | 228 |
Reactive Oxygen Species Regulation of Autophagy in Skeletal Muscles | Abstract Objective: To evaluate the effects of physiological levels of mitochondrial-derived reactive oxygen species (ROS) on skeletal muscle autophagy, a proteolytic pathway designed to regulate contractile and myofilament homeostasis and to recycle long-lived proteins and damaged organelles. Results: Basal levels of ... | E-mail: kissmo@korea.ac.krReceived February 2, 2011, Accepted February 3, 2012Key Words : Chromatin immunoprecipitation, Protein kinase A, Osteoblast, OsteopontinVitamin D receptor (VDR) is a member of nuclear receptorfamily of transcription factors and mediates the molecularactions of 1,25-dihydroxyvitamin D | eng_Latn | 229 |
What are guanosine triphosphate-binding proteins doing in mitochondria? | The discovery of GTP-binding proteins in mitochondria is a recent event. These regulatory proteins may be participating in membrane fusion and thereby playing important roles in the physiology of the mitochondrion. So far, it has been proposed that GTP-binding protein mediated membrane fusion may be involved in protein... | Abstract Preeclampsia is a multisystem disorder unique to human pregnancy, characterized by abnormal placentation. Although its causes remain unclear, it is known that the expression of several transporters is altered. Transient receptor potential vanilloid 1 (TRPV-1) is a nonselective cation channel, present in human ... | eng_Latn | 230 |
Principal component analysis: a review and recent developments | What is principal component analysis? | Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin | eng_Latn | 231 |
Sex differences in longevity and aging are seen throughout the animal kingdom. These are likely to result, in part, from sex differences in endocrinology. In the nematode Caenorhabditis elegans, males are the longer-lived sex. Here we explore the possibility that sex differences in insulin/insulin-like growth factor 1 ... | Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormones known as dafachronic acids (DAs) influence longevity by binding to and regulating the activity of the conserved n... | Females live longer than males in many species, including humans. We have traced a possible explanation for this phenomenon to the beneficial action of estrogens, which bind to estrogen receptors and increase the expression of longevity-associated genes, including those encoding the antioxidant enzymes superoxide dismu... | eng_Latn | 232 |
Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We have previously found that CMA activity declines in aged organisms and have proposed that this failure in cellu... | Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wide liver expression ... | Liver is a vital organ with many important functions, and the maintenance of normal hepatic function is necessary for health. As an essential mechanism for maintaining cellular homeostasis, autophagy plays an important role in ensuring normal organ function. Studies have indicated that the degeneration of hepatic funct... | eng_Latn | 233 |
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging. " Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, th... | During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline. These epig... | The concept of frailty as a medically distinct syndrome has evolved based on the clinical experience of geriatricians and is clinically well recognizable. Frailty is a nonspecific state of vulnerability, which reflects multisystem physiological change. These changes underlying frailty do not always achieve disease stat... | eng_Latn | 234 |
causes of death with parkinson's | Parkinson's disease is not fatal in itself, and many people with Parkinson's have a normal lifespan. But depending on your symptoms, Parkinson's disease can increase the risk of dying from complications such as falls, choking, and pneumonia. | causes of parkinson s disease parkinson s disease is caused by a loss of nerve cells in the part of the brain called the substantia nigranerve cells in this part of the brain are responsible for producing a chemical called dopaminearkinson s disease is caused by a loss of nerve cells in the part of the brain called the... | eng_Latn | 235 |
diseases caused by dysfunctional cells | Mitochondrial disease is a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell.itochondrial diseases as a rule are worse when the defective mitochondria are present in the muscles, cerebrum, or nerves, because these cells use more energy than most other cells in the... | Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth.itochondrial diseases result from failures of th... | eng_Latn | 236 |
is coenzyme q a protein | Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe. Cui TZ(1), Kawamukai M. Author information: (1)Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Japan. | 1 Coenzyme Q10 (commonly known as CoQ10) is a compound that is made naturally in the body. 2 The body uses it for cell growth and to protect cells from damage that could lead to cancer (see Question 1). coenzyme helps an enzyme do its job. An enzyme is a protein that speeds up the rate at which natural chemical reacti... | eng_Latn | 237 |
Animal Models of OXPHOS Disorders | Dysfunction of the mitochondrial respiratory chain has been associated with a wide range of human diseases ranging from diabetes to cardiomyopathy. Mutations in a number of nuclear as well as mitochondrial genes have been implicated in causing these diseases. Several animal models have now been created which reproduce ... | Meerkats, Oreo the raccoon and cosy craft sessions are on offer to keep the kids entertained over half-term at Sandwell’s Oak House Museum. | kor_Hang | 238 |
Smoking cessation increases the resistance of low-density lipoprotein to oxidation | Abstract The effects of smoking cessation on the susceptibility to oxidation of low-density lipoprotein (LDL) was investigated in 14 men who quit smoking for 3 months. LDL was isolated and susceptibility of LDL to V-70 (4-methoxy-2,4-dimethylvalerinitrile)-mediated oxidation was assessed by measuring conjugated diene p... | Abstract To identify changes in proteins accompanying transformation of normal lung epithelial cells to cancer cells, we performed a comparative proteomic study using two cell lines representing matching normal and cancer cells. Strikingly, a good number of detected actin cytoskeletal proteins were preferentially downr... | eng_Latn | 239 |
Apoptotic mechanisms in mutant LRRK2-mediated cell death. | Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant Parkinson's disease. The pathological mutations have been associated with an increase of LRRK2 kinase activity, although its physiological substrates have not been identified yet. The data we report here demonstrate that dise... | Introduction ::: Left atrium (LA) mechanical functions and atrial electromechanical delay (AEMD) times were considered independent predictors of cardiovascular morbidity in general population. Data are scant about these parameters in end-stage renal disease (ESRD) patients receiving hemodialysis (HD) and peritoneal dia... | eng_Latn | 240 |
Clinical Features of Rhabdomyolysis After Open and Laparoscopic Roux-en-Y Gastric Bypass | Background ::: Rhabdomyolysis (RML) is caused by muscle injury, this may cause kidneys overload and lead to acute renal failure (ARF). The risk factors for RML in bariatric surgery (BS) are operative time (OT) >4 h and high BMI. The frequency of RML in BS varies from 12.9 to 37.8%. This study has the objective of descr... | Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant Parkinson's disease. The pathological mutations have been associated with an increase of LRRK2 kinase activity, although its physiological substrates have not been identified yet. The data we report here demonstrate that dise... | eng_Latn | 241 |
Autophagy and Inflammatory Cell Death, Partners of Innate Immunity | Alas, it is the law of the evolutionary jungle that any host defen! se mechanism that efficiently kills microbes also exerts a strong selective pressure for tolerant variants to emerge. A silver lining in this otherwise dark cloud is that pathogens can be exploited as powerful tools to examine host defense mechanisms. ... | AbstractBackground: Application of hepatoprotectants, such as drugs or cytokines, can reduce drug-induced hepatotoxicity (DIH). Due to species-specific differences and abnormal cell polarity and dr... | eng_Latn | 242 |
Programmed cell death: Superman meets Dr Death | This year's Cold Spring Harbor meeting on programmed cell death (September 17-21, 2003), organised by Craig Thompson and Junying Yuan, was proof that the 'golden age' of research in this field is far from over. There was a flurry of fascinating insights into the regulation of diverse apoptotic pathways and unexpected n... | Over the past several years, a number of clinical prediction rules have been developed to estimate mortality and determine appropriate disposition to | eng_Latn | 243 |
Mitochondrial dysfunction and cell senescence: cause or consequence? | The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of... | Technology scaling has enabled increased speed, lower energy consumption and lower die cost. However, new reliability issues appear in these deep sub-micron technologies. The aging of devices during circuit operation will have to be considered during the circuit design phase, so that models that represent the modified ... | eng_Latn | 244 |
A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations | The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidative phosphorylation i... | Author contributions ::: ::: GH helped design the study, establish the animal model, collect and analyze samples, and write the manuscript. YY and DH helped establish the animal model, performed Western blotting, immunohistochemistry analyses. YY and DH also helped analyse data and revise the manuscript. QYW and JK con... | kor_Hang | 245 |
Non-identical twins Evelyn and Edith born 1909 when Edward VII on throne .
World's oldest twins will celebrate their 104th birthdays on Friday .
Lives have seen two World Wars, discovery of penicillin and moon landing .
Between them they have eight children, 21 grandchildren, 47 great-grandchildren, and six great-great... | By . Chris Pleasance . PUBLISHED: . 11:39 EST, 10 November 2013 . | . UPDATED: . 12:20 EST, 10 November 2013 . In 1909 Queen Victoria had been dead for eight years, her successor Edward VII was on the throne and World War I was still five years from starting. That year also saw the birth of Evelyn and Edith in Scotland... | Living to the ripe old age of 500 might be a possibility if the science shown to extend worms' lives can be applied to humans, scientists have said. U.S. researchers tweaked two genetic pathways in the tiny lab worm Caenorhabditis elegans and boosted the creature's lifespan by a factor of five. The research raises the ... | eng_Latn | 246 |
bone broth..chicken carcass, lamb bones with some meat left out for 3 hours from pressure cooking I left my bone broth out after pressure cooking for 3 hours. It was warm when I got home and consisted of a chicken carcass, lamb bones with a bit of meat and the second boiling of marrow beef bones with some vinegar. It g... | How do I know if food left at room temperature is still safe to eat? If I left food out of the refrigerator for some period of time, is it still safe? If I left it out too long, can I salvage it by cooking it more? | why do chaperones bring protein into mitochondria? why would mitochondria need protein? Sounds trivial? Please help to sort out. I saw this picture while looking at dehydration reactions and cell revision. And proceeded to the Protein Folding and Processing in the ER: Various changes occur to proteins in the ... | eng_Latn | 247 |
What was Daenerys Targaryen's motive in the final chapter of A Game of Thrones? If you haven't read the book massive spoilers ahead... It's been years since I've read the book but is it ever explicitly said what Daenerys' motive was for putting the dragon eggs, Mirri Maz Duur, and herself into Drogo's funeral pyre?... | Was Daenerys actually trying to hatch the eggs? I was reading @Aegon' s response and I realized that I've never been clear on whether Dani was intentional in her pyre building to do blood magic and wake the dragons, or if she was just grieving Drogo and killing Mirri and her statement about "only death can pay for li... | why do chaperones bring protein into mitochondria? why would mitochondria need protein? Sounds trivial? Please help to sort out. I saw this picture while looking at dehydration reactions and cell revision. And proceeded to the Protein Folding and Processing in the ER: Various changes occur to proteins in the ... | eng_Latn | 248 |
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase | The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways | studies rethinking bank efficiency and regulation : how off - balance - sheet activities make a difference . | eng_Latn | 249 |
Everything Hertz: methodological issues in short-term frequency-domain HRV | The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance | Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages | eng_Latn | 250 |
Substrate Integrated Waveguide (SIW) Monopulse Slot Antenna Array | A broadband substrate integrated waveguide (SIW) filter | Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils | eng_Latn | 251 |
The BCL-2 (B cell CLL/Lymphoma) family is comprised of approximately twenty proteins that collaborate to either maintain cell survival or initiate apoptosis(1). Following cellular stress (e.g., DNA damage), the pro-apoptotic BCL-2 family effectors BAK (BCL-2 antagonistic killer 1) and/or BAX (BCL-2 associated X protein... | Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential step is controlled and mediated by proteins of the Bcl-2 family. The proapoptotic p... | Proteasome inhibitors induce rapid death of cancer cells. We show that in epithelial cancer cells, such death is associated with dramatic and simultaneous up-regulation of several BH3-only proteins, including BIK, BIM, MCL-1S, NOXA, and PUMA, as well as p53. Elevated levels of these proteins seem to be the result of di... | eng_Latn | 252 |
Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormones known as dafachronic acids (DAs) influence longevity by binding to and regulating the activity of the conserved n... | Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2 and age-1 encode components of an insulin-like signaling pathway. Both daf-2 and age-1 act at a similar point in the genetic epistasis pathway for dauer arrest... | Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype. The Age phen... | eng_Latn | 253 |
Molecular mechanisms leading to myocardial injury during warm or cold ischemia are insufficiently understood. Although proteasomes are thought to contribute to myocardial ischemia-reperfusion injury, their roles during the ischemic period remain elusive. Because donor hearts are commonly exposed to prolonged global col... | Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR stimulation leads to mPTP openings is elusive. Here, we show that chronic administration of isoproterenol (ISO) persistently increases the fre... | The principal function of the proteasome is targeted degradation of intracellular proteins. Proteasome dysfunction has been observed in experimental cardiomyopathies and implicated in human congestive heart failure. Measures to enhance proteasome proteolytic function are currently lacking but would be beneficial in tes... | eng_Latn | 254 |
In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis). The following conclusions are made. (I) ATP and rather often mitochondrial hyperpolarization (i.e. an increase in membrane potenti... | The bulk of ATP consumed by various cellular processes in higher eukaryotes is normally produced by five multimeric protein complexes (I-V) embedded within the inner mitochondrial membrane, in a process known as oxidative phosphorylation (OXPHOS). Maintenance of energy homeostasis under most physiological conditions is... | Recent studies suggest a close relationship between cell metabolism and apoptosis. We have evaluated changes in lipid metabolism on permeabilized hepatocytes treated with truncated Bid (tBid) in the presence of caspase inhibitors and exogenous cytochrome c. The measurement of β-oxidation flux by labeled palmitate demon... | eng_Latn | 255 |
Autophagy plays a central role in regulating important cellular functions such as cell survival during starvation and control of infectious pathogens. Recently, it has been shown that autophagy can induce cells to die; however, the mechanism of the autophagic cell death program is unclear. We now show that caspase inhi... | Reactive oxygen species (ROS) are potentially harmful to cells because of their ability to oxidize cell constituents such as DNA, proteins, and lipids. However, at low levels, and under tight control, this feature makes them excellent modifiers in a variety of signal transduction pathways, including autophagy. Autophag... | Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic materials, little is known about the role of autophagy in ... | eng_Latn | 256 |
what does ap biology involve | Develop advanced reasoning and inquiry skills as you design experiments, collect and analyze data using mathematics and other methods, and interpret that data to draw conclusions. AP Biology Course Overview (PDF) AP Biology Course & Exam Description (PDF) | Apoptosis (from Ancient Greek á¼ÏÏÏÏÏÏÎ¹Ï falling off) is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chrom... | eng_Latn | 257 |
what is iphlpapi.dll | Iphlpapi.dll is a type of DLL file associated with MSDN Disc 1550 developed by Microsoft for the Windows Operating System. The latest known version of Iphlpapi.dll is 1.0.0.0, which was produced for Windows. This DLL file carries a popularity rating of 1 stars and a security rating of UNKNOWN. | Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.n the nervous system, IP 3 serves as a second m... | eng_Latn | 258 |
what is pqq used for | PQQ offers a viable alternative. The enormous amount of energy generated within the mitochondria exposes them to constant free radical activity. The resulting mitochondrial decay is a hallmark of aging. PQQ protects and augments delicate mitochondrial structures to promote youthful cellular function in three distinct w... | Rating Newest Oldest. Best Answer: Opurt is correct, however it is a bit of an interesting story. PQ was always used until the separatist Pari Quebecois became the government. They insisted that 'PQ' be changed to 'QC' and to delete reference that Québec was only the province of a country. Source(s): | eng_Latn | 259 |
The Australian experience in organ donation--2003. | A Systematic Literature Review and Research Agenda for Organ Donation Decision Communication | 1954 The Pure Theory of Public Expenditure | eng_Latn | 260 |
Council aides did not have a total for the savings that would be realized in city agency legal departments through its plan. | A savings would be realized in city legal departments if the plan was implemented. | The plan would bring no savings to the city agency legal departments. | eng_Latn | 261 |
99 on the voucher by transposing the seven and the one, the approving official and the certifying officer, who might generally expect much lower taxi fares, would have no basis to assess the reasonableness of the claim. | Certifying officers would often expect taxi fares to be much lower. | Certifying officers have all of the evidence they need to assess the claims. | eng_Latn | 262 |
1. Deputy Director Maxim Thorne says the plan would threaten innovative programs that have expanded the range of services offered, and won awards and broad community support. | The Deputy Director won awards for his statements about the new plan. | There was no plan being proposed, especially not one that would have any effect on current programs. | eng_Latn | 263 |
Just before the R97 case was filed, when many in the community were concerned about the size of the Service's request, I suggested that a case calling for rates to be phased--in over time might help avoid the rate shock that comes with large, double digit increases. | The community was concerned about the size of the Service's request. | The size of the Service's request had no effect on the R97 case. | eng_Latn | 264 |
For example, an LSC grantee could represent a welfare claimant who argued that an agency made an erroneous factual determination or that an agency misread or misapplied a term contained in an existing welfare statute. | They can represent claimants that say the agency has made a mistake. | The LSC grantees are prevented from making claims. | eng_Latn | 265 |
While preserving the neighborhood groups' own boards of directors, the proposed plan makes them accountable to one central LSNY board for decisions like staffing and budgets. | The suggested plan makes them accountable to a board. | The suggested plan makes them accountable to no one. | eng_Latn | 266 |
The propertyrelated fee increase requires voter approval under Proposition 218, a process Tulare County Water Works officials started after they learned the outcome of Alpaugh Irrigation's vote. | Prop 218 requires voter approval for fee increase. | Fee increases can happen at any time if the board says so. | eng_Latn | 267 |
Cell-based leakage power reduction priority (CBLPRP) optimization methodology for designing SOC applications using MTCMOS technique | This paper describes a straightforward cell-based leakage power reduction priority (CBLPRP) optimization methodology for designing highspeed low-power SOC applications using MTCMOS technique. The CBLPRP methodology is based on the cell swapping priority depending on the total leakage power reduction for a cell changing... | With a huge budget, the sloping land conversion program(SLCP)has profound significance in china. We evaluate the economics theoretical basis of SLCP and reveal the internal economics logic of SLCP in a framework of mainstream economics. Firstly, we discuss the limitation of beginning to collect Pigou taxes in the frame... | eng_Latn | 268 |
Parliament and Non-Sovereign Law-Making Bodies | In my last chapter I dwelt upon the nature of Parliamentary sovereignty; my object in this chapter is to illustrate the characteristics of such sovereignty by comparing the essential features of a sovereign Parliament like that of England with the traits which mark non-sovereign law-making bodies. | Thousands turned out last weekend to protest at cuts, deficits, and increasing private sector involvement in the NHS. ::: ::: The “Day of Action” was organised by NHS Together, a collaboration of health service unions, NHS staff … | eng_Latn | 269 |
Addressing Health and Social Care in Easington: Partnership in Practice | This Case Study examines a practical example of joint commissioning in action, in Easington, County Durham. It explores the collaborative processes and particularly the contribution of groups operating at strategic (district) and operational (village) levels. Key individuals made important contributions to the developm... | Constituents will get the chance to chat with their local MP at his regular ‘shoppers surgery’ to be held at the Sainsbury’s store on Wetherby Road ... | eng_Latn | 270 |
British IVF clinics on a "gravy train": Robert Winston | People are being sucked into IVF without a full recognition of exactly how low the success rate is. | Abstract It would seem that many industrial companies in the UK, even though their profit margins are being squeezed, still have money to burn, literally. Although fuel prices have escalated quite sharply over the past two decades, the cost of energy is not yet high enough to force companies to implement conservation m... | kor_Hang | 271 |
Council seeking views on proposed Public Spaces Protection Order | The proposed PSPO seeks to replace and consolidate a number of existing orders that are in place in Cheltenham. | The offence of controlling or coercive behaviour came into effect in England and Wales in December 2015, and related offences have since been enacted in Scotland and Ireland. To date, there has bee... | eng_Latn | 272 |
Contingent or Structural Crisis in British Agriculture | The British agricultural sector is either already in or rapidly approaching some sort of crisis. Two features are particularly significant in the political response to the current situation. First, there is an increasingly neoliberal approach to agricultural policy. Sec end, agricultural policy per se is being subsumed... | Building socialism new countryside needs finance support,but the shortage of present countryside cpital is a factor of hindering countryside development.adds vigour to the development of countryside society and economy,but as the lack of law and government protection to countryside finance,the irregular countryside fin... | eng_Latn | 273 |
The Outlook for State and Local Government Finances | City? (Washington, D.C.: The Urban Institute, October 1972). 10. Leona Vogt, et al., Health Start: Final Report of the Evaluation of the Second Year Program (Washington, D.C.: The Urban Institute, December 1973). 11. Bayla White, et al., The Atlanta Project: How One Large School System Responded to Performance Informat... | EDITOR—I received 21 items of correspondence about my personal view on separating the NHS from direct government involvement, mostly supporting the idea and many urging me to take it further.1 I have worked in the NHS for 28 years and my conclusions are based on first hand experience of the waste associated with massiv... | eng_Latn | 274 |
Turnaround of the Indian Railways: a public ownership saga | The reported turnaround of the Indian Railways (IR) has attracted wide notice. This article locates the enterprise within the broader Indian public sector and explores the factors that led to the turnaround from a low performing organisation to a high performing one. The case study method is used, with the developing t... | Thousands turned out last weekend to protest at cuts, deficits, and increasing private sector involvement in the NHS. ::: ::: The “Day of Action” was organised by NHS Together, a collaboration of health service unions, NHS staff … | eng_Latn | 275 |
What does a colour TV licence cost? | Official TV Licensing website - TV Licence types and costs / TV Licence types and costs TV Licence types and costs It costs £145.50 for a colour and £49.00 for a black and white TV Licence. In some cases, you may be entitled to a reduced fee TV Licence (see table below). You’re entitled to a 50% reduction in your TV Li... | Michael Howard - ORG Wiki Michael Howard Michael Howard MP (Conservative) former MP for Folkestone & Hythe. Former leader of the Conservative Party. Issues Freedom of Information Signed Early Day Motion 2699 Freedom of Information 10 December 2006 That this House welcomes the finding of the Constitutional Affairs Commi... | eng_Latn | 276 |
Which two words complete the names of these financial institutions Furness, Principality and Skipton? | Savings compensation and protection: Bank ownership and licences | This is Money comments The way you spread out your savings is crucial in terms of protection and compensation, but it is also a system that can be difficult to navigate. We explain who covers what Protected against a bust: Make sure your savings are saf... | Somerset Conservatives | Covering the Bridgwater & West Somerset, Somerton & Frome, Taunton Deane, Wells, and Yeovil parliamentary constituencies Covering the Bridgwater & West Somerset, Somerton & Frome, Taunton Deane, Wells, and Yeovil parliamentary constituencies Main navigation Hill Farms ‘Must be Ring-Fenced Again... | eng_Latn | 277 |
How much good the Norplant option would do is debatable. | It is questionable how much benefit the Norplant option will provide. | Everyone know that the Norplant option is very beneficial. | eng_Latn | 278 |
it's going to be reduced right uh-huh | It'll be reduced. | It will be expanded. | eng_Latn | 279 |
It is designed to give the utilities flexibility in determining how and where to achieve the reductions. | Utilities will have flexibility in determining how to reduce rates. | Utilities only want to raise their rates. | eng_Latn | 280 |
The results are in quadrillion Btu in both the reference case and each of the four policy scenarios. | The results are present in the policy scenarios. | The results were not relevant to them. | eng_Latn | 281 |
defending the decision to deny benefits will deliver the government's message in the litigation. | The governments message will be delivered by defending the decision to deny benefits. | The governments message was to deny benefits. | eng_Latn | 282 |
This process would yield an estimate for cases that are funded exclusively with LSC resources. | The process would yield an estimate | The process wouldn't yield an estimate | eng_Latn | 283 |
The new policy narrows the definition to providing legal advice or representation to people who cannot afford it. | The recent changes in policy allow better access for legal advice for those who are short-handed. | The new policy makes it harder for poor people to get legal advice. | eng_Latn | 284 |
Not surprisingly, the push for a shrinkocracy has gained little support. | Shrinkocracy has gained little help despite the push for it. | Shrinkocracy has gained massive support. | eng_Latn | 285 |
The reconfiguration is part of a nationwide effort by LSC to boost cost-effectiveness by reducing the number of providers through a competitive bidding process imposed by Congress under a 1996 law. | LSC believes it's important to limit the number of providers via a competitive bidding process. | It was imposed by Congress under a 1941 law. | eng_Latn | 286 |
This risk can be acceptably mitigated if the plan calls for invoice examination to be commensurate with the risk to the government. | There is a practical way to mitigate the risk. | There is no way to mitigate the risk. | eng_Latn | 287 |
Smaller towns will have a syndicat d'initiative, which provides the same services. | The syndicat d'initiative in smaller towns give the same services. | Smaller towns will not be able to offer similar services. | eng_Latn | 288 |
There would be no government second guessing and lengthy permit reviews. | The government cannot change their mind. | The government can change their mind. | eng_Latn | 289 |
Passaic Legal Aid argues that LSC used the consolidation process to deny funding based on performance without a required hearing. | LSC can deny funding. | LSC doesn't have the ability to deny funding. | eng_Latn | 290 |
Does Performance Pay Increase Job Satisfaction? | Effects Of Devolved Government Practices On Health Service Provision In Pastoral Communities: A Case Study Of Wajir County | It is premature to test older drivers with the SIMARD-MD | eng_Latn | 291 |
If there are no applicable domestic studies, there are many ways to utilize the international literature to conduct benefit transfer (BT). In the health economics literature simple unit transfer methods, rather than function-based methods, are the most commonly used. In this chapter we utilize a large database of Value... | Cost-Benefit Analysis is a method to assess the effects of policies and projects on social welfare. CBAs are usually applied in a top-down approach, in the sense that a decision-making body first decides on which policies or projects are to be considered, and then applies a set of uniform criteria to identifying and va... | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 292 |
In this report, the results of interviews with sixty local health care politicians in southern Sweden will be presented. It is evident from the material that despite their formal responsibility, the politicians are of the opinion that other actors exert greater influence upon the allocation of resources. They do not th... | In both English and Swedish health care, there is currently much interest in encouraging public consultation and participation in public service planning in order to improve quality, enhance local accountability, and help to inform and legitimize difficult decisions about health care priorities. This article explores t... | Every function of n inputs can be efficiently computed by a complete network of n processors in such a way that: If no faults occur, no set of size t n /2 of players gets any additional information (other than the function value), Even if Byzantine faults are allowed, no set of size t n /3 can either disrupt the comput... | eng_Latn | 293 |
Prior to 2008, reference to green infrastructure (GI) in Irish planning, advocacy and guidance documentation had been limited. However, by November 2011, GI was referenced in statutory guidance at national, regional and local levels, while also enjoying reference in many non-statutory planning policy and advocacy docum... | The urban heat island effect, in which cities are hotter than surrounding rural areas, will be exacerbated by climate change impacts for many Australian cities. Heatwaves already kill more people than other natural disasters, and have significant impacts on productivity and liveability. Vegetation is one of the most ef... | Blunt trauma abdomen rarely leads to gastrointestinal injury in children and isolated gastric rupture is even rarer presentation. We are reporting a case of isolated gastric rupture after fall from height in a three year old male child. | eng_Latn | 294 |
Case Study on Power Quality Improvement of Thirty Bus System with UPFC | The unified power flow controller (UPFC) is a pair of back to back power electronic inverters which controls the real and reactive power flow in a transmission line. This paper describes the modeling and simulation of IEEE 30 bus system employing UPFC. Simulink models are developed for IEEE 30 bus system with and witho... | In urban-rural planning,tenure is a very important and unavoidable issue.On the mode of the system of rural collective construction land tenure,in the town planning area turns right concessions were took,but outside of town planning protect right concessions were took.Sense of profit is very obvious in the mode of the ... | eng_Latn | 295 |
Extra-constitutionalism, the Human Rights Act and the Labour 'Rebels' : applying Prof. Tushnet's theories in the UK. | The control of executive power during periods of emergency is important but complicated. One key problem arises from the need to guarantee that the executive does not abuse its power at a time when there can be considerable pressure to act, while at the same time ensuring that the courts do not prevent the executive fr... | In urban-rural planning,tenure is a very important and unavoidable issue.On the mode of the system of rural collective construction land tenure,in the town planning area turns right concessions were took,but outside of town planning protect right concessions were took.Sense of profit is very obvious in the mode of the ... | eng_Latn | 296 |
Increasing the benefits of chemotherapy by ameliorating the adverse effects. | When cancer is first diagnosed in most patients, it is usually incurable. Chemotherapy can cause remissions, prolonged disease-free survival, and prolonged survival in general, but it is associated with considerable toxicity to the physical and mental well-being of the patient. The number of side-effects increases when... | Purpose – The purpose of this paper is to shed light onto the policy context of mainstreaming community-based adaptation (CBA) in Nepal. Scaling up CBA needs strong policy support. Design/methodology/approach – The content and processes of Nepal’s development policies and climate change policies and programmes were exa... | eng_Latn | 297 |
Development of a plug-and-play multiple RTU coordination control algorithm for small/medium commercial buildings | There have been very few advanced control algorithms developed for small commercial buildings due to practical difficulties such as the spatial comfort variations, significant disturbances, high sensor costs, and high cost of site-specific engineering solutions. High implementation cost has been a major impediment to s... | In urban-rural planning,tenure is a very important and unavoidable issue.On the mode of the system of rural collective construction land tenure,in the town planning area turns right concessions were took,but outside of town planning protect right concessions were took.Sense of profit is very obvious in the mode of the ... | eng_Latn | 298 |
LONG-TERM DURABILITY OF CONCRETE ---NORDIC CONCRETE RESEARCH | The objective of the present project is to investigate the long-term durability characteristics of various types of concrete exposed to various environments. The project is carried out as a semi-full scale project with a total concrete volume of 2 cu m for each of the 16 different types of concrete. The activities with... | In urban-rural planning,tenure is a very important and unavoidable issue.On the mode of the system of rural collective construction land tenure,in the town planning area turns right concessions were took,but outside of town planning protect right concessions were took.Sense of profit is very obvious in the mode of the ... | yue_Hant | 299 |
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