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41312557 | Autoimmune Hepatitis | An association between antibiotic usage during pregnancy and the subsequent development of autoimmune hepatitis. | Whether the incidence of autoimmune hepatitis (AIH) is higher in women prescribed antibiotics during pregnancy remains to be determined. Administrative databases and hospital abstracts were reviewed to identify all pregnant women in the province of Manitoba from 1996 to 2001 who were prescribed antibiotics during pregn... | DILI ; antibiotics ; autoimmune hepatitis ; hepatitis ; liver disease ; urinary tract infections | [
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40176882 | Bakers Cyst | Ruptured Tubercular Baker's Cyst: A Case Report. | Background: Although tuberculosis (TB) can affect any organ, ruptured Baker's cyst due to TB is an uncommon phenomenon. Case Summary: A young lady presented with unilateral atraumatic knee and calf pain and swelling. Pain characteristics shared both mechanical and inflammatory natures. Constitutional features for TB we... | extrapulmonary TB ; ruptured Baker's cyst ; tubercular Baker's cyst | [
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41596217 | Cystitis | Urinary Biomarkers for Radiation Cystitis: Current Insights and Future Directions. | Radiation cystitis (RC) is a clinically challenging and often progressive complication of pelvic radiotherapy, marked by urothelial injury, vascular dysfunction, chronic inflammation, and fibrotic remodeling. Early diagnosis remains elusive due to nonspecific symptoms and the absence of validated molecular tools. As a ... | bladder ; radiation cystitis ; urinary biomarkers | [
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41687083 | Preeclampsia | Assessment of human placental microbial signatures in pre-eclampsia using shotgun metagenomics. | This study evaluated the presence of bacterial species in the placenta of women with pre-eclampsia and compared with that of normotensive women. One hundred and twenty participants, comprising 60 pre-eclamptic (30 early- and late-onset, respectively) and 60 age-matched normotensive women (30 early and late-gestation no... | bioinformatics ; microbiota ; placenta ; pre-eclampsia ; shotgun metagenomic | [
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34089885 | Viral Gastroenteritis | Rotavirus gastroenteritis in children hospitalized in northeastern Poland in 2006-2020: Severity, seasonal trends, and impact of immunization. | The introduction of the rotavirus vaccine in 2006 significantly reduced childhood incidence of acute gastroenteritis (AGE) worldwide. The rotavirus vaccine was included in Poland's national immunization program in 2021. Our study aimed to summarize the epidemiology of AGE in northeastern Poland prior to 2021 and to eva... | Children ; Hospitalization ; Rotavirus ; Vaccine coverage ; Viral gastroenteritis | [
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41599848 | Diabetic Retinopathy | Modulating One-Carbon Metabolism with B-Vitamins to Protect the Retinal Barrier and Prevent Retinal Degeneration. | Vitamin B12 deficiency is increasingly recognized as a contributor in both vascular and neurodegenerative aging-related disorders. Its deficiency disrupts one-carbon metabolism, leading to impaired homocysteine (Hcy) cycling. Elevated Hcy is a well-established risk factor for vascular dysfunction. Previously, we establ... | B-vitamins ; age-related macular degeneration ; blood–retinal barrier ; diabetic retinopathy ; homocysteine | [
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41730180 | Autonomic Neuropathy | Cardiorespiratory Markers of Type 2 Diabetes: Machine Learning-Based Analysis. | The global prevalence of type 2 diabetes mellitus (T2DM) poses significant challenges due to its association with increased cardiovascular risk and complications like cardiovascular autonomic neuropathy. Measures derived from heart rate variability (HRV) and cardiorespiratory interactions quantified through frequency r... | cardiorespiratory coupling ; diabetic autonomic neuropathy ; frequency response function ; heart rate variability ; impulse response ; machine learning ; type 2 diabetes | [
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41415131 | Overactive Bladder | The Prolapse Quality of Life Questionnaire can be Used to Assess Urinary Storage Conditions in Patients Undergoing Laparoscopic Sacrocolpopexy. | Patients with pelvic organ prolapse (POP) tend to have urinary storage symptoms. The prolapse quality of life questionnaire (P-QOL) is used to assess POP-related symptoms. However, whether the P-QOL can evaluate storage conditions before and after POP surgery remains unclear. This study aimed to evaluate whether the P-... | Laparoscopic sacrocolpopexy ; overactive bladder symptom score ; pelvic organ prolapse ; prolapse quality of life questionnaire | [
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40809359 | Toxoplasmosis | Fallow deer approaching humans are more likely to be seropositive for Toxoplasma gondii. | Toxoplasma gondii infection has been linked to dampening hosts anti-predator behaviour particularly in laboratory conditions with rodents. Little is known about the role of T. gondii within more complex ecological contexts involving large mammals. Therefore, we aimed to determine the prevalence of T. gondii infection i... | Dama dama ; Toxoplasma gondii ; animal behaviour ; host manipulation ; parasitology ; risk taking ; serology ; toxoplasmosis | [
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38076245 | Cataracts | The effectiveness and safety of one-stage iStent-based micro-invasive glaucoma surgery-A retrospective study. | Micro-invasive glaucoma surgery involves a group of treatment methods associated with a low rate of side effects and good effectiveness outcomes. One of the most frequently performed procedures belonging to this group is iStent microstent implantation. The aim of this study was to perform a retrospective evaluation of ... | MIGS ; cataracts ; glaucoma–surgery ; iStent ; intra ocular pressure | [
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39626363 | Restless Legs Syndrome | Motor cortex excitability in restless legs syndrome: A systematic review and insights into pathophysiology via transcranial magnetic stimulation. | Restless Legs Syndrome (RLS) is a neurological disorder characterized by a complex and only partially understood pathophysiology. Numerous studies have investigated motor cortex excitability in RLS using transcranial magnetic stimulation (TMS), but a comprehensive systematic review assessing their methodological qualit... | Motor cortex ; Neural networks ; Neurophysiology ; Pathophysiology ; Restless legs syndrome ; Systematic review ; Transcranial magnetic stimulation | [
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41445601 | Constipation | Type 1 Dolichocolon as a Potential Anatomic Co-Morbidity in Pediatric Perianal Crohn's Disease. | Perianal Crohn's disease (PCD) represents one of the most severe and refractory forms of pediatric inflammatory bowel disease (IBD). Constipation and colonic redundancy, particularly type 1 dolichocolon (T1-DC), may increase distal rectosigmoid pressure, and exacerbate perianal pathology. We hypothesized that T1-DC is ... | colonic redundancy ; constipation ; dolichocolon ; fecal diversion ; pediatric IBD | [
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41736038 | Cellulitis | Volumetrics and abscess-to-orbit ratio in surgically managed subperiosteal abscesses. | CT scan ; Orbital cellulitis ; Sinusitis ; Subperiosteal orbital abscess ; Volumetrics | [
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39197706 | Chiari Malformation | Multi-Dimensional Morphometric and Volumetric Analysis of the Posterior Cranial Fossa to Study Type I Chiari Malformation. | Chiari malformation type I (CM-1) is a complex disorder in which tonsillar herniation through the foramen magnum (FM) manifests with a spectrum of clinical symptoms. This work analyzes morphometric and volumetric characteristics of CM-1 patients. With institutional review board approval, we retrospectively reviewed a t... | Chiari malformation ; Decompression surgery ; Morphometrics ; Posterior fossa ; Suboccipital craniectomy ; Tonsillar ectopia ; Volumetric | [
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41589756 | Migraine With Aura | Reduced Frequency of Prolonged Sporadic Hemiplegic Migraine Attacks Following Fremanezumab Treatment-A Case Report. | Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway have emerged as a potential therapeutic option. A 64-year-old m... | calcitonin gene‐related peptide receptor antagonists ; headache ; humans ; migraine disorders ; migraine with aura | [
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41630841 | Valley Fever | Investigation and response to rift valley fever outbreak in ruminant livestock from Ngoma District, eastern province of Rwanda, 2024. | Rift Valley fever (RVF) is a zoonotic mosquito-borne disease, causing high livestock morbidity and mortality, with potential human spillover. Rwanda has experienced repeated outbreaks, including significant ones in 2018 and 2022. In August 2024, a smaller localized outbreak was reported in Ngoma District, Eastern Provi... | One health response ; Outbreak investigation ; Rift Valley fever ; Rwanda ; Zoonoses | [
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41634790 | Nasopharyngeal Carcinoma | Fusobacterium nucleatum manipulates host autophagy to promote its intracellular survival and treatment resistance in nasopharyngeal carcinoma. | Growing evidence highlights the existence and tumor-promoting role of intratumoral bacteria in various types of cancers. However, the mechanisms enabling the intracellular survival of these microorganisms remain poorly understood, impeding the development of microbiota-targeting anticancer strategies. A transcriptomics... | Fusobacterium nucleatum ; Autophagy ; FadA ; Nasopharyngeal carcinoma ; RAB7A ; Treatment resistance | [
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41780620 | Ovarian Cancer | Aloperine exerts anti-ovarian cancer effects by regulating the tricarboxylic acid cycle and glycolysis: A comprehensive study integrating network pharmacology, molecular docking, metabolomics, and experimental validation. | Aloperine (ALO), an alkaloid derived from Sophora alopecuroides L., demonstrates therapeutic potential against malignant tumors, while the role of ALO and its molecular mechanisms in ovarian cancer remain unclear. This study aims to systematically investigate the efficacy and molecular mechanisms of ALO against ovarian... | ALO ; TCA ; glycolysis ; metabolomics ; network pharmacology ; ovarian cancer | [
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40509791 | Gastroparesis | Same-Day Discharge, Medical and Non-Medical Admission After Per-Oral Endoscopic Pyloromyotomy. | Gastric per-oral endoscopic myotomy (G-POEM) is a promising treatment for gastroparesis. Our previous pilot study has indicated that about 50% of patients could be safely discharged home on the same day as the procedure. In this study, we presented more data on this topic and divided admission into medical and non-medi... | gastric per‐oral endoscopic myotomy ; gastroparesis ; patient admission | [
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41441972 | Dystonia | ANO3-related tremulous dystonia: case report. | A 21-year-old woman presented with a severe tremor and involuntary spasms in her hands. Her tremor started at the age of seven, and while it was initially mild and only in bilateral upper extremities, its severity increased over time. There is no consanguinity between her parents, and her early developmental milestones... | ANO3 ; DYT-ANO3 ; Dystonia ; Tremulous dystonia | [
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41650538 | Adhd | Game on but pay the price: Hyperfocus, flow, escapism, self-efficacy, and burnout among video gamers with ADHD traits. | Hyperfocus-an intense, uncontrollable state of attention-has gained attention for its dual adaptive and maladaptive outcomes and its potential role in gaming experience. Although distinguishing hyperfocus from flow during gameplay may be challenging, their predictive factors (e.g., escapism motivation) and consequences... | ADHD ; Flow ; Hyperfocus ; Video games | [
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39698146 | Primary Progressive Aphasia | Neuroanatomical correlates of language impairment in non-fluent variant of primary progressive aphasia. | Non-fluent variant of primary progressive aphasia (nfvPPA) is a neurodegenerative disorder with a predominantly speech and language impairment. Apraxia of speech and expressive agrammatisms along with decreased speech fluency and impaired grammar comprehension are the most typical disorder manifestations but with the c... | agrammatisms ; apraxia of speech ; functional connectivity ; neurolinguistics ; primary progressive aphasia ; voxel-based morphometry | [
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40370674 | Prehypertension | Prevalence of prehypertension and undiagnosed hypertension among urban bankers of Bangladesh: A cross-sectional study. | Bankers live a sedentary and highly stressful life that often leads to developing noncommunicable diseases (NCDs) such as hypertension, diabetes, mental disorders, etc. The study aims to assess the prevalence of undiagnosed hypertension and prehypertension among urban bankers in Bangladesh. Data from 365 bankers from f... | Bangladesh ; bankers ; noncommunicable diseases ; occupational health ; prehypertension ; undiagnosed hypertension ; urban | [
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"Diabetes ",
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39683505 | Phenylketonuria | The Prevention of Maternal Phenylketonuria (PKU) Syndrome: The Development and Evaluation of a Specific Training Program. | Maternal phenylketonuria (PKU) syndrome, leading to severe psychomotor retardation, microcephaly, cardiac defects and undergrowth, affects the unborn children of mothers with PKU with insufficient metabolic control during pregnancy. To improve long-term outcomes, a specific prevention program was developed. We designed... | maternal PKU syndrome ; preconceptional training ; pregnancy in phenylketonuria (PKU) ; prevention ; training program | [
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39975316 | Progressive Supranuclear Palsy | DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci. | Frontotemporal lobar degeneration (FTLD) represents a spectrum of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders. The two major FTLD pathological subgroups are FTLD-TDP and FTLD-tau. While the majority of FTLD cases are sporadic, heterogeneity also exists within the familial cases... | DNA methylation ; Epigenetics ; Frontotemporal dementia ; Frontotemporal lobar degeneration ; Neurodegeneration ; Progressive supranuclear palsy ; disease risk | [
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40892260 | Gender Dysphoria | Post-surgical outcomes in transgender women: a prospective analysis of sexual function and health-related quality of life. | To prospectively evaluate patient and clinician reported outcomes of sexual function and health-related quality of life (QOL) of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2) after gender-affirming surgery (GAS) with penile inversion vaginoplasty. Transgender women undergoing two-stage GAS at... | Gender affirming surgery ; Gender dysphoria ; Quality of life ; Sexual function ; Transgender women | [
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35977619 | Botulism | Dual-Toxin ("Bivalent") Infant Botulism in California, 1976-2020: Epidemiologic, Clinical, and Laboratory Aspects. | To assess the consequences of infant botulism that result from Clostridium botulinum strains that produce 2 botulinum toxin serotypes, termed "bivalent." Epidemiologic investigations used a standard questionnaire. Clostridium botulinum strains were isolated by standard methods. Botulinum neurotoxin (BoNT) serotypes and... | Clostridium botulinum ; botulinum toxin ; botulism immune globulin | [
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40824471 | Snoring | Identifying phenotypes in OSA patients with an indication for CPAP treatment using clinical data and experienced symptom severity. | Although the group of patients with obstructive sleep apnea (OSA) is very heterogeneous, OSA's severity is mainly expressed by an apnea-hypopnea index (AHI), which does not correlate well with the experienced symptom severity. As a first step to develop a more personalized approach for treatment, the purpose of the cur... | Daily activity ; Fatigue ; Obstructive sleep apnea (OSA) ; Patient Reported Apnea Questionnaire (PRAQ) ; Phenotyping ; Snoring severity | [
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35380283 | Bile Reflux | A 3-year follow-up study of uncut Roux-en-Y reconstruction: clinical results and outcomes. | The goal of this study was to identify the clinical outcomes of uncut Roux-en-Y reconstruction in patients who underwent totally laparoscopic distal gastrectomy (TLDG) over 3-year follow-up. From January 2016 to December 2017, 269 patients who underwent TLDG were enrolled in the study and analyzed retrospectively. They... | Bile reflux ; Gastrectomy ; Gastritis ; Reconstructive surgical procedures ; Remnant stomach ; Stomach neoplasms | [
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38162433 | Travelers Diarrhea | Epidemiological trends of traveler's diarrhea in Japan: An analysis of imported infectious disease registry data from 2017-2022. | Traveler's diarrhea (TD) is a global problem, and identifying the causative organisms of TD is important for adequate treatment. Therefore, this study retrospectively analyzed TD cases in patients who returned to Japan after traveling abroad to determine the causative organisms by travel region. We included patients wi... | C-reactive protein ; epidemiology ; travel diseases ; traveler's diarrhea | [
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38700505 | Stomach Cancer | Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer. | Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response to treatment. Understanding the molecular network driving the rapid progression of stomach cancer is crucial for improving patient outcomes. This study aimed to investigate the role of unfolded protein response (... | IGFBP1 ; prognostic signature ; stomach cancer ; tumor immune microenvironment ; unfolded protein response | [
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34619676 | Dry Skin | A Biomimetic Combination of Actives Enhances Skin Hydration and Barrier Function via Modulation of Gene Expression: Results of Two Double-Blind, Vehicle-Controlled Clinical Studies. | Xerosis cutis is characterized by a decreased stratum corneum (SC) hydration and an impaired skin barrier function. Urea, the most prevalent natural moisturizing factor (NMF), is currently considered the gold standard. Its efficacy can further be increased by combining urea with other NMF and skin barrier lipids (SBLs)... | Ceramide ; Dry skin ; Gene expression ; Natural moisturizing factor ; Urea ; Xerosis cutis | [
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41559315 | Vertigo | Case report and literature review of subclavian steal syndrome presenting with otologic symptoms as the initial clinical manifestation. | Subclavian steal syndrome (SSS) seldom manifests with isolated otologic symptoms, and sudden sensorineural hearing loss (SSNHL) as the initial presentation is infrequent. This case underscores the critical-though often overlooked-relationship between vertebrobasilar hemodynamics and inner ear perfusion, broadening the ... | Hearing loss ; Subclavian steal syndrome ; Vertigo | [
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41807238 | Acute Coronary Syndrome | Highlights and Perioperative Implications from the 2025 American College of Cardiology and American Heart Association Guideline for the Management of Patients with Acute Coronary Syndromes. | Acute coronary syndromes (ACS) are some of the most well-studied diseases in clinical medicine. To organize this information into useful recommendations for the clinician, in 2025 the American College of Cardiology and the American Heart Association updated and compiled the data into the Guideline for the Management of... | ST elevation MI ; acute coronary syndrome ; cardiogenic shock ; dual antiplatelet therapy ; non-ST elevation MI ; percutaneous coronary intervention | [
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40197430 | Binge Eating Disorder | Psychometric properties of the German version of the Eating Pathology Symptoms Inventory. | The Eating Pathology Symptoms Inventory (EPSI) is a multidimensional self-report measure for the assessment of eating pathology and related aspects: Body Dissatisfaction, Binge Eating, Cognitive Restraint, Purging, Restricting, Excessive Exercise, Negative Attitudes Toward Obesity, and Muscle Building. The aims of the ... | Anorexia nervosa ; Assessment ; Binge eating disorder ; Bulimia nervosa ; Eating disorders | [
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41626062 | Primary Biliary Cholangitis | Primary Biliary Cholangitis: Novel and Emerging Therapies. | Primary biliary cholangitis (PBC) is a slowly progressive autoimmune liver disease that, if not promptly and appropriately treated, can lead to significant morbidity, mortality, and a substantial decline in patients' quality of life. Ursodeoxycholic acid is the first-line therapy; however, up to 40% of patients exhibit... | Primary biliary cholangitis ; farnesoid X receptor ; peroxisome proliferator-activated receptor agonist ; pruritus ; therapy ; ursodeoxycholic acid | [
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41704260 | Chest Pain | Commentary: Evaluation of AI-enhanced tele-ECG response time and diagnosis in acute chest pain patients. | AI-assisted diagnosis ; acute chest pain ; clinical integration ; methodological evaluation ; tele-ECG | [
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41262466 | Kawasaki Disease | Risk Factors and Regression of Coronary Aneurysms in Infants With Kawasaki Disease. | The purpose of this study is to analyze clinical characteristics of patients with Kawasaki disease (KD) aged below 1 year and identify risk factors for coronary aneurysm (CA) and its associated prognosis. A retrospective study enrolling infants (under 1 year of age) with KD admitted to a children's hospital between Jan... | Kawasaki disease ; coronary aneurysm ; infants ; regression ; risk factors | [
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28625289 | Genital Herpes | No. 207-Genital Herpes: Gynaecological Aspects. | The purpose of this guideline is to provide recommendations to gynaecology health care providers on optimal management of genital herpes. More effective prevention of complications and transmission of genital herpes. Medline was searched for articles published in French and English related to genital herpes and gynaeco... | HSV ; antiviral ; counselling ; genital herpes ; prevention ; screening | [
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41787360 | Spinal Cord Injury | Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-responsive brown adipose tissue for targeted neuroinflammation modulation. | Spinal cord injury (SCI) affects over 15 million people globally with no curative treatments available. While primary mechanical trauma initiates tissue damage, secondary pathological cascades including neuroinflammation and mitochondrial dysfunction expand the injury. Current clinical interventions focus only on sympt... | Angiopep-2 ; Brown adipose tissue ; Extracellular vesicles ; MiR-692 ; Neural inflammation ; PET/CT ; SPP1 ; Spinal cord injury | [
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41650099 | Malaria | Implications of out-of-pocket payments for the control of malaria in developing countries: A narrative review. | This narrative review investigates the implications of out-of-pocket (OOP) payments for malaria treatment in developing countries by synthesizing evidence from peer-reviewed articles, reports, and policy documents. A thematic approach was employed to analyze key areas, including economic impacts on households, barriers... | developing countries ; financial barriers ; health policy ; healthcare access ; malaria ; out-of-pocket payments ; socioeconomic impact | [
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41752946 | Metabolic Syndrome | Obesity, Metabolic Syndrome and MASLD in Children: Inflammation as the Missing Link-A Short Narrative Review. | Childhood obesity has emerged as a major global health challenge, with a marked increase in prevalence. Defined by excessive fat accumulation, it is associated with an increased risk of developing metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD). These conditions share comm... | MAFLD ; MASLD ; hepatic steatosis ; inflammation ; metabolic syndrome ; obesity | [
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39377824 | Drug Allergy | Preventing Overrides of Severe Drug Allergy Alerts Initiative: an Implemented System Upgrade. | Administering medications to patients with documented drug hypersensitivity reactions (DHR) poses a significant risk for adverse events, ranging from mild reactions to life-threatening incidents. Electronic healthcare systems have revolutionized the modern clinical decision-making process, with built in warnings. Howev... | Alert Fatigue ; Allergy Alert ; CPOE ; Drug Hypersensitivity Reactions ; Drug-Allergy Reaction ; Override ; Patient Safety | [
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41460997 | Cerebral Palsy | Picture Me Moving: A Photovoice Study of Families and Children With Motor Disabilities Using Modified Ride-on Toy Cars. | We investigated the long-term impact and use, from the families' perspectives, of modified ride-on cars for children with motor disabilities. We used Participatory Action Research using photovoice methods with 13 families of young children with disabilities. Families collaborated as coresearchers by capturing photograp... | adapted ride-on cars ; cerebral palsy ; children with disabilities ; developmental disabilities ; mobility limitation ; participatory research | [
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40368813 | Aortic Valve Disease | Calcific Aortic Valve Disease - From Mechanism to Treatment. | Calcific aortic valve disease (CAVD) is one of the most prevalent heart valve diseases and is characterized by progressive stiffening and calcification of the aortic valve. For decades, CAVD has been treated with surgical intervention. In recent years, some progress has been made in understanding the pathogenesis of CA... | Calcific aortic valve disease ; Mechanism ; Treatment | [
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31540324 | Hht | Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. | Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, ... | BMP ; HHT ; TGF-β ; TRIM family ; cancer ; endoglin ; endothelial cells ; galectin family ; preeclampsia ; protein–protein interactions | [
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41572192 | Antiphospholipid Syndrome | The diagnostic and prognostic values of non-criteria antiphospholipid antibodies in obstetric antiphospholipid syndrome. | Obstetric antiphospholipid syndrome (OAPS) is a subtype of antiphospholipid syndrome associated with adverse pregnancy outcomes. Non-criteria antiphospholipid antibodies (aPLs) were focused in recent years, but the diagnostic and prognostic values of them in OAPS were rarely explored. A single-center retrospective stud... | Anti-phosphatidylserine/prothrombin ; Non-criteria antiphospholipid antibodies ; Obstetric antiphospholipid syndrome ; Pregnancy complications | [
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