id stringlengths 16 27 | title stringlengths 18 339 | abstract stringlengths 95 38.7k | category stringlengths 7 44 |
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10.1101/2022.05.05.22274717 | Temporal Characterization of Longitudinal Sequelae Including Acute Pain, Physiologic Status, and Toxicity Kinetics in Head and Neck Cancer Patients Receiving Radiotherapy: A Prospective Electronic Health Record Embedded Registry Study. | BackgroundPain is a common, debilitating symptom experienced by patients with oral cavity and oropharyngeal cancer (OC/OPC) treated with radiotherapy (RT). Managing acute pain (AP) over 6 - 7 weeks of RT remains a significant challenge, warranting further investigation. Using a modern prospective registry, the objectiv... | health informatics |
10.1101/2022.05.07.22274792 | Assessing the feasibility of sustaining a 'Zero-COVID' policy in China in the era of highly transmissible variants | We developed a spatially structured, fully stochastic, individual-based SARS-CoV-2 transmission model to evaluate the feasibility of sustaining a 'Zero-COVID' policy in mainland China in light of currently dominant Omicron variants, China's current immunization level, and non-pharmaceutical intervention (NPI) strategie... | infectious diseases |
10.1101/2022.05.03.22274517 | Escape of SARS-CoV-2 variant Omicron to mucosal immunity in vaccinated subjects. | Omicron s escape to vaccine-induced systemic antibody responses has been shown in several studies in Omicron-infected patients and vaccine controls.
In the present study we compared mucosal antibody response to Omicron to mucosal antibody response to ancestral strain and Delta variant. This was done on nasal epithelia... | infectious diseases |
10.1101/2022.05.06.22274786 | The mortality risk factor of severe community-acquired pneumonia (SCAP) patients with Sepsis: a retrospective study | ObjectivesSepsis is one of the most common comorbidities in severe community-acquired pneumonia (SCAP) patients. We aimed to investigate the characteristics and mortality risk factors of SCAP patients hospitalized with Sepsis.
DesignA retrospective, single-centre study.
SettingThis study was conducted at a tertiary h... | intensive care and critical care medicine |
10.1101/2022.05.05.22274742 | A Novel method for estimating right atrial pressure with point-of-care ultrasound (POCUS) | Current noninvasive estimation of right atrial pressure (RAP) by either bedside jugular venous pressure (JVP) exam or inferior vena cava (IVC) measurement during a formal echocardiogram offer imprecise estimates of actual RAP. We enrolled 41 patients in a prospective, blinded study to validate a novel point-of-care ult... | cardiovascular medicine |
10.1101/2022.05.07.22274789 | Estimates of excess mortality for the five Nordic countries during the Covid-19 pandemic 2020-2021 | Excess deaths during the covid-19 pandemic are of major scientific and political interest. Here we review excess all-cause death estimates from different methods for the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden), which have been much studied during the covid-19 pandemic. In the comparison of... | epidemiology |
10.1101/2022.05.06.22274755 | Seroprevalence of SARS-CoV-2 Antibodies among vaccinated and non-vaccinated adults in the West Bank: Results of a repeated cross-sectional study | BackgroundSeroprevalence studies are known to provide better estimates of the proportion of people previously infected, which did not undertake diagnostic testing. Repeated cross-sectional sero-studies are encouraged in the same locations to monitor trends overtime. The aim of this study was to assess the seroprevalenc... | epidemiology |
10.1101/2022.05.05.22274700 | "We just considered it to be over there" : A qualitative study exploring urban perspectives for disease introduction | Rift Valley fever virus (RVFV) is a zoonotic arbovirus that is also transmitted to humans from fluids and tissues of infected livestock. Urban areas in Kenya have the hosts, dense vector distributions, and source livestock (often from high-risk locations to meet the demand for animal protein ) , yet there has never bee... | epidemiology |
10.1101/2022.05.04.22274675 | "Does a respiratory virus have an ecological niche, and if so, can it be mapped?" Yes and yes. | Although the utility of Ecological Niche models (ENM) and Species Distribution models (SDM) has been demonstrated in many ecological applications, their suitability for modelling epidemics or pandemics, such as SARS-Cov-2, has been questioned. In this paper, contrary to this viewpoint, we show that ENMs and SDMs can be... | epidemiology |
10.1101/2022.05.05.22274722 | Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom | ObjectivesThis study aimed to assess contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people in the United Kingdom as they are an understudied genetic ancestry group with high rates of parental relatedness and disproportionate disease burden.
... | gastroenterology |
10.1101/2022.05.05.22274726 | Construction of a short version of the Montreal Cognitive Assessment (MoCA) rating scale using Partial Least Squares analysis | BackgroundThe Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognitive impairment (aMCI) and Alzheimers disease (AD).
ObjectivesThe aims of this study are to a) evaluate the construct validity of the MoCA and its subdomains or whether the MoCA can ... | psychiatry and clinical psychology |
10.1101/2022.05.05.22274695 | Reporting Rates for VAERS Death Reports Following COVID-19 Vaccination, December 14, 2020-November 17, 2021 | BackgroundDespite widely available safety information for the COVID-19 vaccines, vaccine hesitancy remains a challenge. In some cases, vaccine hesitancy may be related to concerns about the number of reports of death to the Vaccine Adverse Event Reporting System (VAERS).
ObjectiveTo provide information and context abo... | public and global health |
10.1101/2022.05.04.22274510 | Altered Lateralization of the Cingulum in Deployment-Related Traumatic Brain Injury: An ENIGMA Military-Relevant Brain Injury Study | Traumatic brain injury (TBI), a significant concern in military populations, is associated with alterations in brain structure and function, cognition, as well as physical and psychological dysfunction. Diffusion magnetic resonance imaging (dMRI) is particularly sensitive to changes in brain structure following TBI, as... | neurology |
10.1101/2022.05.04.22274181 | Tanycytes are degraded in Alzheimer Disease, disrupting the brain-to-blood efflux of Tau | The accumulation of pathological Tau in the brain and cerebrospinal fluid (CSF) and its eventual increase in the blood are hallmarks of Alzheimers disease (AD). However, the mechanisms of Tau clearance from the brain to the periphery are not clear. We show here, using animal and cellular models as well as patient blood... | neurology |
10.1101/2022.05.06.22274756 | A Genome-Wide Association Study of Survival in Patients with Sepsis | BackgroundSepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units (ICUs). Most genetic studies have identified gene variants associated with development and outcomes of sepsis focusing on biological candidates. ... | genetic and genomic medicine |
10.1101/2022.05.05.22274505 | Acetylation of Adenine Nucleotide Translocase, Fuel Selection, and Metabolic Flexibility in Human Skeletal Muscle | Introduction: Healthy, resting skeletal muscle primarily oxidizes lipid, but insulin resistant muscle oxidizes carbohydrate and shows metabolic inflexibility during hyperinsulinemia. It is unclear whether fuel selection and metabolic flexibility are dependent on insulin sensitivity in skeletal muscle performing mild ex... | endocrinology |
10.1101/2022.05.05.22274544 | Aggressive Antipyretics in CNS Malaria: Study Protocol of a Randomized-Controlled Trial Assessing Antipyretic Efficacy and Parasite Clearance Effects (Malaria FEVER Study) | Background : Despite ongoing eradication efforts, malaria remains a major public health challenge in Africa where annually, ~250,000 children with malaria experience a neurologic injury with subsequent neurodisability. Evidence indicates that among children with CNS malaria, a higher temperature during the acute illnes... | neurology |
10.1101/2022.05.08.22274809 | Behavioral Effects in Disorders of Consciousness Following Transcranial Direct Current Stimulation: A Systematic Review and Individual Patient Data Meta-analysis of Randomized Clinical Trials | Background: In patients with Disorders of Consciousness (DoC), transcranial direct current stimulation (tDCS) was a promising intervention for it. However, uncertainties remain about the treatment effect and the optimal treatment strategy of the tDCS in the DoC. Objective: In this meta-analysis of individual patient da... | neurology |
10.1101/2022.05.06.22274696 | Associations of Midlife Diet Quality with Incident Dementia and Brain Structure: Findings from the UK Biobank Study | Objective: To investigate the associations of midlife diet quality with incident dementia and brain structure. Design: Population-based prospective study and cross-sectional study. Setting: UK Biobank. Participants: In total, 187,783 participants (mean age 56.8 years, 54.9% women) who completed the 24-hour recall dieta... | nutrition |
10.1101/2022.05.06.22274584 | Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids. | Since the start of the COVID-19 global pandemic, our understanding of the underlying disease mechanism and factors associated with the disease severity has dramatically increased. A recent report investigated the relationship between substance use disorders (SUD) and the risk of severe COVID-19 in the United States and... | genetic and genomic medicine |
10.1101/2022.05.06.22274613 | Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron Variant of Concern | Background Recent in-vitro data have shown that the activity of monoclonal antibodies (mAbs) targeting SARS-CoV-2 varies according to the Variant of Concern (VOC). No studies have compared the clinical efficacy of different mAbs against Omicron VOC. Methods The MANTICO trial is a non-inferiority randomised controlled t... | infectious diseases |
10.1101/2022.05.06.22274772 | Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Vaccinated and Unvaccinated Patients in Mexico City | Background: Coronavirus disease 2019 (COVID-19) vaccines are very effective at protecting against severe disease and death. However, the impact of the vaccine used, viral variants, and host factors on disease severity in vaccinated individuals remain poorly understood. Here we compared COVID-19 clinical presentations a... | infectious diseases |
10.1101/2022.05.06.22274767 | How to improve access to TB care for the nomads? Review of barriers and enablers for Sahel nomadic populations | Background Tuberculosis (TB) control in nomadic populations represents a major public health problem in sub Saharan Africa. Methods Barriers and enablers of TB care for nomads were identified through a literature review and survey conducted among the National TB Programs (NTPs) of six Sahelian countries: Burkina Faso, ... | infectious diseases |
10.1101/2022.05.05.22274749 | Measuring the impact of nonpharmaceutical interventions on the SARS-CoV-2 pandemic at a city level: An agent-based computational modeling study of the City of Natal. | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic hit almost all cities in Brazil in early 2020 and lasted for several months. Despite the effort of local state and municipal governments, an inhomogeneous nationwide response resulted in a death toll amongst the highest recorded globally. To eval... | epidemiology |
10.1101/2022.05.07.22274794 | Neighborhood distribution of availability of newer tobacco products: A four-site study, 2021 | Background: Audits of tobacco retail stores can identify marketing patterns as newer tobacco products are introduced in the US. Our study examined store and neighborhood correlates of availability of nicotine pouches and disposable e-cigarettes in four US sites. Methods: We conducted standardized store audits of n=242 ... | public and global health |
10.1101/2022.05.07.22274793 | Partial and Radical cystectomy Provides Equivalent Oncologic Outcomes in T2 Bladder Cancer: a Population-Based Study | Purpose: To compare the oncologic outcomes of T2 bladder cancer (BCa) patients after partial cystectomy (PC) or radical cystectomy (RC). Materials and Methods: Relevant data of T2 BCa patients diagnosed between 2004 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results database. After propensity ... | oncology |
10.1101/2022.05.06.22274683 | Validation of a transcriptome-based assay for classifying cancers of unknown primary origin | Cancers assume a variety of distinct histologies and may originate from a myriad of sites including solid organs, hematopoietic cells, and connective tissue. Clinical decision making based on consensus guidelines such as NCCN is often predicated on a specific histologic and anatomic diagnosis, supported by clinical fea... | oncology |
10.1101/2022.05.06.22274685 | Accuracy and Glycemic Efficacy of Continuous Glucose Monitors in Critically Ill COVID-19 Patients: a Retrospective Study | Background: Continuous Glucose Monitoring (CGM) is approved for insulin dosing decisions in the ambulatory setting, but not currently for inpatients. CGM has the capacity to reduce patient-provider contact in inpatients with coronavirus disease 2019 (COVID-19), thus potentially reducing in hospital virus transmission. ... | endocrinology |
10.1101/2022.05.05.22274434 | Routine Saliva Testing for SARS-CoV-2 in Children: Partnering with Childcare Centers in the Greater New Haven Community | Background: While considerable attention was placed on SARS-CoV-2 testing and surveillance programs in the K-12 setting, younger age groups in childcare centers were largely overlooked. Childcare facilities are vital to communities, allowing parents/guardians to remain at work and providing safe environments for both c... | infectious diseases |
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