Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
P0CY20 | 3.1.3.7 | ACT_SITE 54; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179"; ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179" | MSHTTHPYQKELEVATLAVKRASLLTKQLSDSIVQTARSGTLTKDDKSPVTIGDFASQAIINHAIKLNFPSDEIVGEEDSQELQENSSLADQVLSLIIKIQQETSVYNDVVGTLTDKNKVFQSIDYGNSQGGSKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGKVVLGVIGCPNLSENIVSNEEHSGVVGGLYSAVKGVGSFYSELFKEGTEPLSQQKPIKMQNHTNPSQLKVVEGVEKGHSSHSTQAEIKAKLGFDPTTVAKQTVNLDSQVKYCVLASGQADIYLRLPVSDTYREKIWDHAAGNILIYESGGQVGDV... | 151 |
A0A2R6W0X7 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAQSGSFWAVFVVVAILGVAAANAQLSPTFYATKCPGAVAKSAEVVRTWILKDRSMAPALLRLHFHDCFVRGCDASVLLDSTIANSGEKDADGNKNSLRGFEIIDDVKAKIEALCPGVVSCADILALAARDAMQVFGGLNYTVPLGRRDGVSSFAWEANNNLPPPFADWTKLMSIFSTKGLSSKDLVVLSGAHTVGFTRCSTIQSRLYNFSTTIPTDPTLDPSFVPLLKSRCKFGSSGIVMMDLSKTTDTWDFNYYSNVLKGRSLFQSDDALKRTTEGLKLVQAENKAGGPFSADFAASMIKMGNIQVLTGTSGQIRKKC... | 14 |
A0A8V0XZG0 | 2.4.1.18 | ACT_SITE 343; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 398; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MAASGTQGPQAPKLPELLERDPYLAPFERDFQRRYALFYKRLKSIDDNEGGLNKFSKSYKSFGVNQFVDGGVYCKEWAPGAEAVFLTGDFNGWNPFSHPYKKMEYGKWELFIPPGQDGFSPVPHGSKLKVVIRAQNGELLYRISPWARYVVRYEGKVNYDWVHWDPPQSYIRKHRSPKKLKSLRIYESHVGIASPEGKIASYKNFTYNVLPRIRDLGYNCIQLMAVMEHAYYASFGYQVTSFFAASSRYGTPDDLKELIDVAHSMGITVLLDVVHSHASKNSEDGLNKFDGTDSCFFHSGPRGTHRIWDSRLFDYANWEV... | 73 |
B3SDM0 | 4.1.1.17 | ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MVIIHQWKMRLRNVEIFYAMKCNNDPVLLRTLINLGVSFDCASLGEIQSILNAGVNPDRIIYANTIKAISHLRFAKEKNVNLTVFDNEDELYKIKKYHPNAKLAIRICPDMEVCESRFQLGIKFGAAKADVAHLLEVAQSLKLNVVGVSFHVGSDCLTPIAYEKGIITSKQIFKLAEKFGYHFNLLDIGGGFTAFSALETTFAKAAAVISKALQKYFPPELGVRIIAEPGRYFATRACTLVLNVIGRRVVRKGNGDLFDFEHENAHLYKNTNDFEKVLYYVNDSVYGCLNILPIDHALITLKPVKSNTHGEETAVLFGQT... | 195 |
I1ITK9 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSFVKLSVALTCLLLLSSTCHGSHGPNVGHYKKTCPNAEAIVRDSVKSSVYKDAGVGAGLIRLLFHDCFVQGCDGSVLLDPSPSNPQPEKLSAPNFRSLRGFEAVDAAKAAVERACPGVVSCADVVAFAARDAAYFLSGLRVKADMPGGRLDGRVSRSDEAARDLPPASANLAQLVSNFAAKGLGEEDMVVLSGAHSVGASHCSSFVPGGRLEGPGRSDMDAGLAAVLKKQCAPGQNPLVPQDAVSPNALDSQYYRNVLAHKVLLPSDAALLAAPATEKMVRDNAYVPGKWEGKFAEALVKMAAIGVKTGQQGEIRKN... | 14 |
A0A3B6C7J9 | 2.4.1.18 | ACT_SITE 484; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 539; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MASPAFAVSAAGLARPSTPRSGGAERRGRGVELQSPSLLFGRNKGTRSPRAVSVGGSGWRVVMRAGGPSGEVMIPDGGSGGTPPSIDGPVQFDSDDLKVAFIDDEPSLQDEGEDSIWSSETNQVTEEIDVEGTNIMDKESSTGEKLRIVPPPGNGQQIYEIDPTLRDFKYHLEYRYSLYRRIRSDIDEHEGGMDVFSRGYEKFGFMRSAEGITYREWAPGADSAALVGDFNNWDPNADHMSKNDLGVWEIFLPNNADGSPPIPHGSRVKVRMDTPSGIKDSIPAWIKYSVQTPGDIPYNGIYYDPPEEEKYVFKHPQPKR... | 73 |
A0A3B5XW91 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKHCFSLAAALAVVTLAALLSSDAVVACIDVGFYDRTSPSAETLVQQTVAAAFGNDSGVPPAIIRLHFHDCFVKGCDGSVLIDSTPGNKAEKDSAPNFPSLRFFDVVDRAKAALEAQCPGVVSCADVLAFAARDSIVLSGGLGYQVPAGRRDGRVSTETDALNNLPGPTSTASDLVAGFAAKNLTVEDIVVLSGAHNIGVSHCSSFTERIYNFPNTTDGIDPKLSKAYAFLLKGICPPNSNQTFPTTTTLMDLITPARFDNKYYVGLANNLGLFQSDAALLTNATMKSLVDSFVRSEAAFRTRFARSMLKMGQIEVLSGA... | 14 |
A9SZ95 | 5.1.3.3 | ACT_SITE 181; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MGVSKGNLTEECVGDGVFLYTLERGGVRAVFTNWGATLMSLCVPDARGEIGDIVLGFDTLGPYTDGTSPYFGAIVGRVANRIARGTFILDGERFTLPVNNGPNSLHGGYVGFDKVLWEARKVTDGNGPSVQFTYHSHDGEQGYPGDLDVSVTYTLSSDCELRTEMEAKPVNKATPVNLAQHSYFNLAGHGSGDVLQHRVRLWSTSYTPLDDTQIPTGEIVPVRGTAFDFTEEASIGSRINDVPGGYDHNFDLRSGLEDPAGDLHPLNGGDLLGDGLRIAAKVWDPVSRRAMEVFTTAPGVQFYTGNYVDGIVGKGGAVYN... | 211 |
Q0U736 | 2.3.2.26 | ACT_SITE 1815; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTAHKSSNLDRVTRSAARRSTGSADDNTPNPNPPPPPPPPPPTRAPASNRKRKTAPPSSSPEPEAEQEEEAPARSSRAKRTKVDSQKKHARSKKAKGKAAMSAAESVPTAPQEDVRLTSDSQSNNPTDEKMSTPQPSSARRKGARKNDGSRRNPKTPGNDADPDAPSTSLRSSRKANNAEEDTAMEDAPEEQEDETRPPGEDSDEDDEEGPGGRYDEDDDEDDDDDDDPFSSGFLGRNPHSLAALRQLTGMMSGTTQRLRGILEQLRSVDVTMQLVALQELSETTWLAIFAPDAYVKELVKLMQPNEFTGEENPEVMLLA... | 65 |
B3RLY4 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MVIAVGDKIPSYRLQQGSPGNNVDIAELVANKKAIIFGVPGAFTPGCHRSHLPGYVADYDKIVAKGVDIIICVSVNDAFVVDAWGKSVGAENKVVMLADPVAAFTKAIGMDLDATPILGNIRSKRYSMILSDGVLTNLNVEPDGTGLTCSLSNSILSQL | 12 |
A0A059BWZ9 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKAFVPSALFLVALHLISATVRAGGLPVEAYGLSFQYYQESCPNFEAIVSRKVKEWIKKDYTLAPALMRLHFHDCVVRGCDASILLNYPGSERSAAESKTLRGFEVINDIKVALEKSCPKMASCADILTSAARDATVLAGGPFWMVPYGRKDGRVSVAKEASKVPVGHENVTSLLQLFQSQGLNVLDLVVLSGAHTIGRSTCGSIQSRLYNYKSTGKPDPTLNREYGNYLKRKCRWASEYVYLDGRTPKTFDNMYYKNLQKKMGLLSTDQYLNSDSRTGPLVSALATQPELFNYQFGVSMAKLGNVQVLTGDEGEVRTNC... | 14 |
A0A078HP26 | 3.1.1.11 | ACT_SITE 439; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFQDFDKIQERVNANRKRKFRKRIIVGTVSLLVVVAAIIGGAFAYVAFEKQNEQEPKNNHKNDAKDSQKKSQSASPTPKAPVAAAQSVKPGQADKIIETLCSTTLYKVSCENTLKNRTEKGFAVESPTTFLKAAIEAVNEDLDRVLEKVLSLKTENQDDKDAIAQCKLLVEDAKEEIVASLNKVNGTEINNFVKIVPDLDNWLSAVMSYQETCIDGFEEGNLKSEVKKTVNSSQVLTSNSLALIKSFDANISPVEKVATRHLLDQIPSWVTNEDRRMLRAVDVETLNPNATVAKDGSGNFTTINDALKAMPEKYEGRYI... | 125 |
P52496 | 6.5.1.1 | ACT_SITE 304; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYPSAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASRIISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMERFFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKHEMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFK... | 254 |
A0A9J7HGI7 | 2.7.11.30 | ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | MTSVHVWLRLGLILYAAGLSLCAAVDTTCEFYDNSECENQENCNSTSRFVMCKDEQQQEEGKRSHCYALWKNESNVITLVKKGCWLDDNDCYDKSECYEHDEAPEKGMFYCCCEGNLCNQHFDHLPIPQPDRSTAETPRTVPVDNSKELFRSLMYSLFPICGIALVVAVTFYMYKRHKSEHIQCFTRHKTEHVQIPTQDPLPPPPSPLLGLRPLQLLEVKARGRFGAVWKAQLLNEYVAVKIFPLQDKASWLNEQDIFTTQLMKHDNLLQFIAVEKRGDGLEMELWLITAFHERGSLTDYLKGHLLKWSEMCHIAETMAR... | 106 |
C6KSV3 | 2.2.1.1 | ACT_SITE 415; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MNIMDNEIDTKCINEIRMLSAELPLEAKSGHQGAPIGCAPIAHILWSYVMNYYNEDTKWINRDRFILSNGHASALLYTMLYLTEQGLSMEDLKSFRQFGSLTPGHPENHITKGVEVTTGPLGQGASNAVGMAIAAHNLADKYNTEEHKIFDNYVYAICGDGCMQEGVFCEAASLAGHLGLGRLILLYDDNKITIDGNTDLSFTENIEKKFEALNWEVRRVEDGNKDYKKILHEIEQGKKNLQQPTLIIVRTACGFGTKVEGTCKSHGLALNDEDLKNAKSFFGLDPQKKFHISDEVKEFYKNVIQKKKENYIKWKNMFDD... | 51 |
A0A1U8ME82 | 1.11.1.7 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNKYKMAELVLPMPFPLSISKASRMRNQALILLCIVVFGVIGTCHGGSLRKKYYKKTCPNAEEIIKTATEKHVANDPTLPARFLRMHFHDCFVRGCDGSVLLNSTTNNSAEKDAIPNLTLAGFDVIDDIKAEVEKKCPNVVSCADVLALAARDAVSFKFQRPLWEVLTGRRDGRVSRVSEALANLPSPFSNFTTLVRNFANQGLNVHDLVVLSGGHTIGVGHCNAFSNRLYNFTGRGDQDPSLNPTYAAFLKTQCRNLTDNTTFVPMDPGSVFTFDNNYYVTVKQNKGLFQSDAALLTNKGSRNIVNELVDPKKFFTEFA... | 14 |
Q9NLA1 | 2.7.11.1 | ACT_SITE 172; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPINYNRNAVELKLSSQLLQWLDQRLPLGDPMRIPSIDSYKYIQDLGKGRFGTVCKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNT... | 99 |
A0A3B3IGP2 | 4.2.1.11 | ACT_SITE 251; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 384; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MTHTLPLPLLVIRFSHLLLFRLFLIHPCALLLSTRLQTNCRMSIVNIFAREILDSRGNPTVEVDLHTEKGLFRAAVPSGASTGIYEALELRDGDKTRYKGKGVTKAVSHINDSLGPALTQSGISVLEQEKLDNLMIEMDGTDNKSKFGANSILGVSLAICKAGAAEKGVPLYRHIADLAGNGELVLPVPAFNVINGGSHAGNRLAMQEFMVLPVGAESFRDALRVGAELYQTLRNVIKEKYGQDATNVGDEGGFAPNIQENSEALELIKTAIEKAGFTDKVVIGMDVAASEFFSEGKYDLDFKSPPNAARNISADELAGI... | 200 |
A0A022QXG1 | 1.11.1.7 | ACT_SITE 51; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNMMVKSGYGLSMNYYMMACPFADMVIRNTVNKALQSDPTLAAALVRMHFHDCFVEGCDGSVLIDSTKDNTAEKDSPANLSLRGYEIIDAAKDALERQCPGVVSCADILAMAARDAVFFAGGPFYDLPKGRKDGRRSKIEDTINLPPPTLNSSELITMFGKRGFTAQEMVVLSGGHTLGMARCSSFKSRLTNFDSTHDVDPNLDTQFARTLLKTCSGGDKAEQPFDSSRNSFDNDYFNALQRKAGVLVSDQTLFASAMTRGMVNAYATNQAMFFFDFQRAFVKMGLMDVKEGSKGEVRNTCRIIN | 14 |
A0A022QAM3 | 3.1.1.11 | ACT_SITE 370; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKLSLFFFFFSYVCSHAVFADDDVSIKKGTISWWCSTTPHPDPCNHFIMMGRYNPNQHNPITRQDFRTLTIQAAMERAIHVQTRAKNLCFQGKSKRKKTVHRDCYNLIGNTIHQLNTTFRSIQKTSNATSDAQTWLSAALTNVEICRSGSHDLKIAARFRSPILSGYVSELISNSLAANGALILAANNDPDSGRRFPGRVTPGNRKLLQVSALVLKANVTVSPDGSGQFRSIQAAIDYATSKRVGDGRVVVYVKKGVYEENILINRTMNKVTLVGDGVKHTVITGSRSVSGGFTTYSSATVGVDGAGFMARGITFRNTA... | 125 |
Q8Y6W0 | 2.7.1.11 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MKRIAILTSGGDAPGMNAATRAVVRKAIYEGLEVYGINYGFLGLVNGDIRKLELGSVGDLLHRGGTFLYSARYPEFATEEGQLKGIEQLKKHQIDGLVVIGGDGSYHGAEALTKRGFPTIGIPGTIDNDISGTDFTIGFDTALNTVLDALDKIRDTATSHERTFIIEVMGRDAGDIALWSGLAGGAEAIIVPEESFNMDDVVDRLNKGRERGKKHSIIVVAEGVMSGNEFAKQLAEYGDYHARVTVLGHVQRGGSPTAFDRVLASRLGARSVELLLENRGGLAVGIRENRIVENDISEILKEKHTLDQKLFDLASILSI | 84 |
A0A0A0KNT4 | 3.2.1.52 | ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MFNSRNFFLFLIFPLPLLVPSALADLSQSGFNDSLPYLWPMPSDFTFGNSTLSVDPRLSLLAAGNAGNSEILKAAFDRYRGIIFKHASGVSMLDKLWGRRRTFVYDISELKIDVQSDSEELHLGVDESYTLLVSKKDAHSIIGEATIEAATIYGALRGLETFSQLCTFNYETKDVQIYQAPWYIKDNPRFAFRGLLIDTSRHFLPVDVIKNIIESMAFAKLNVLHWHIVDEESFPLEVPSYPNLWRGAYTKHERYTIEDAYEIVAFAKMRGINVMAEVDVPGHAESWGIGYPDLWPSPSCKEPLDVTKNFTFDLISGILT... | 170 |
Q9C927 | 3.1.3.2 | ACT_SITE 260; /note="Proton donor"; /evidence="ECO:0000250" | MSLETFPPPAGYNAPEQVHITQGDHNGRGMIISWVTSLNEDGSNVVTYWIASSDGSDNKSVIATTSSYRYFDYTSGYLHHAIIKELEYKTKYFYELGTGRSTRQFNLTPPKVGPDVPYTFGVIGDLGQTYASNQTLYNYMSNPKGQAVLFAGDLSYADDHPNHDQSKWDSYGRFVEPSAAYQPWIWAAGNHEIDYAQSIGETQPFKPYKNRYHVPYRASQNKYTPQNSWLQDEFKKVNRSETPWLIVLVHAPWYNSNNYHYMEGESMRVTFEPWFVENKVDIVFAGHVHAYERSERVSNIQYNITDGMSTPVKDQNAPVY... | 145 |
W5MAF3 | 3.2.2.27 | ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MIGQKTINSYFNPVNKKRALEENNEAGEDAKEKKAITPVKRQKTASDGAPTSPPLSPEQLGRIERNKRAALERLAARNVPEGFGESWKKELCAEFGKPYFIRLMSFVAQERGRHTVYPPSHQVFTWTQMCAIRDVKVVILGQDPYHGPGQAHGLCFSVQRPVPPPPSLENMYKELSTDIEGFQHPGHGDLTGWAKQGVLLLNAVLTVRAHQANSHKDQGWEQFTDAVVLWLNRNLEGLVFMLWGAYAQKKGIVIDRKRHHVLQAVHPSPLSVHRGFFGCRHFSKTNELLVKAGKSPIDWEAL | 173 |
Q89KG1 | 3.4.21.92 | ACT_SITE 106; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 131; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGEKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVKHTGQTYKTIEDALERDKFLTANDAKEFGLVDRVIDKRAEEPAAAKTQ | 179 |
O80719 | 2.7.11.1 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSCFGCCGEDDDMHKTADYGGRHNQAKHFPPGNDARHHQASETAQKGPPVVKLQPIEVPIIPFSELKEATDDFGSNSLIGEGSYGRVYYGVLNNDLPSAIKKLDSNKQPDNEFLAQVSMVSRLKHDNFVQLLGYCVDGNSRILSYEFANNGSLHDILHGRKGVKGAQPGPVLSWYQRVKIAVGAARGLEYLHEKANPHIIHRDIKSSNVLLFEDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLNAKSDVYSFGVVLLELLTGRKPVDHRLPRGQQSLVTWATPKLSEDKVKQCVDARLGGDYPPKA... | 99 |
Q8MT28 | 5.1.3.3 | ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MVNVTEDVFANGAVNPFTKSKDTIKRFTLTNGAGMSVQLITRGATITSIKTPDASGQIDDVTLGFDDLAGYQSERNPYFGATIGRVCNRIANGSFYLDGKLVQVSKNRDNKFQLHGGFVGFDKAHWEVVEVRVDGVTLSHTNPDGHEGYPGKVTATASFTLSEDNCLHVQMSALADKTTPVNLTNHSYFNLAGHKSGANGLYEHTIKINAYGITETDQSSIPTGRITPVEGTGFDLRVSSNLGERLKALQPARGYDDNFCVTFSPPQPLAKVARATHPPSGRWLEVVSNQPGVQFYTSNFMPDVERGESPIPGKDGAAYA... | 211 |
Q6IE06 | 3.4.21.4 | ACT_SITE 55; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"; ACT_SITE 100; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274" | MKLVFCILSTLLGTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVLIHPLWVVTSAHCNLPDLRVILGITNPADTTEHDVEVSDYEKMFRHPYFSVSSISYDLMLIKLRRGIKHSYYAKAVKLPQHTVPVNAMCSVSTWAYNLCDVTKEPDSLQTVNVSVISKAECHNAYKAFDIRENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRADVGIYASIFHYMPWIENIMKNN | 177 |
Q9U969 | 3.1.1.5 | ACT_SITE 985; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1105; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MDVLEMLRASASGSYNTIFSDAWCQYVSKQITATVYMYFALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAEL... | 131 |
P36614 | 3.1.3.16 | ACT_SITE 112; /note="Proton donor"; /evidence="ECO:0000250" | MFDLDEWIATVRKCKYLPEHQLKRLCEMVKVILMEESNIQPVRTPVTVCGDIHGQFYDLLELFRVGGELPSTNYIFMGDFVDRGYFSLETFTLFMLLKARYPDKITLLRGNHESRQITQVYGFYDECQTKYGNANVWKYCCQVFDFLTLAAVIDNKILCVHGGLSPEVRTLDQIRILARAQEIPHEGSFCDLMWSDPEDIESWTVSPRGAGWLFGSKVTTEFSQINDLTLIARAHQLVQEGYKYHFADKNLVTVWSAPNYCYRCGNVASVMKVDESLEPEFRIFSAVADEDRTVPPSRKRSEYFI | 144 |
W1P6A4 | 3.5.1.98 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MERSSGIALSSGPDAVKRKVSYFYDPGIGNYYYGQGHPMKPHRIRMAHNLIVHYNLHHLMEINRPCLANTDDIMKFHSEDYVNFLQTVTPETQHEQMRQLKKFNVGEDCPVFDGIFNFCRASAGGSIGAAVKLNRGDADIGINWAGGLHHAKKCEASGFCYVNDIVLGILELLKVHRRVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGHLKDVGFGKGKYYALNVPLNDGMDDESFQRLFRPVIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVRGHADCLRFLRSFNVPLMVLGGGGYTIRNVARC... | 184 |
Q5KNA0 | 3.5.1.2 | ACT_SITE 102; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 228; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 230; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR036936-1... | MAATQLPILEVGQPKGHSPQTKPKLYILDYGAGNVRSLANSINKLGYEFEWIKDESDFDKAEKLIFPGVGSFAQATSSLRTSGLHSRLLKYIASGKPYFGICIGMQVLFSSSSESPGSEGLGVVPFAITEFKVEDNYEGGNGRKSVPHMGWNKAWKAWKSEGDEKGTETLMVDDDYYFVHSYAALLPDPSASAPPNEVADFAYTLSRYGSETFISSIRRDNVFAVQFHPEKSGPAGLDMLKRWLDAPVDSLSSSPANPASTSVGKTWQPVNPSPLRAKGNGLTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVR... | 181 |
W5MQK3 | 2.7.10.1 | ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MGSVSGWRSTGAWGISASRMSTWACLLYLALVSMATVSLARPPFNTEEETTLEPEEPPTKYQISKPTVCSVHPGDLLKLSCPLPEAGTITWTKDGSSLGSNNRTLIVEESLQIRDATPKDSGLYACSTVSPIGSDTLCFIVNVTDAISSGDDEDDTERSEDVPGDGEQMRAPYWTMPEKMEKRLHAVPAANTVKFRCAAGGNPRPHLRWLKNGRNFRQEDRMGGYKVRHQHWTLIMESVVPSDKGNYTCVVENQYGSINHTYTLDVVERSPHRPILQAGLPANTTVRVGEDARFVCKVYSDAQPHIQWLQHIEKNGSRYG... | 97 |
Q54LR6 | 2.7.11.1 | ACT_SITE 429; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGKYYQIFFLLYLLCILYVISCGYINPYSPYSSPCLFAPIIGYLYMGGSLSSNSSNNNNNNNNNNNNNNNNNNNNNNNNNNKDSKLTENCNNNSSNNNSDNKSNIKNKQHHHHSNFRNRRGKSNNKNSSDNDDCTKCNKRHHTQSSSYDTSELHQSVSSGLGGSMGSGSQALTDIEKDINEFMNANPSHSLNKQQIQQQQQLQQQQQQLLKQQQQQQQQQQQQQQQQQQQQLEKQRKEQEETEKKKQLELQQQQQLQQQQQNGNGLIIEEDMMEGRILRNISKVYRDVNENQPKSYYDYEGYRINWKNVDRYEVIQKIGR... | 99 |
Q9SVY5 | 2.7.11.1 | ACT_SITE 191; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MKKQYLKSGSGTRKEKDKAKRWFLDNGSIFLRELVADCNGKSIPIRSFSPEQILKATNNFDSSCFVSQDVYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSGQRLQVEACVVLAL... | 99 |
B9S005 | 3.1.1.11 | ACT_SITE 405; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTIAKVIVGGISIILVVGVCIVLIAGLSNNTDTSAPDENDDNKILSATSMAVAAFCNQTDHKHRCVDSVFSVARNQSATFNDFLKAAISYTIEHVKLAMDTAATIGKDAKDSTQKMAVEDCQELLQFAIGELQDSLLTVKNSSFDAVKEREADLKNWLSAVMSYKETCLDGLNDTNLHKPMSDGLVNATELTSNALAIVSAISDIGNAFRIPSNLNASATRRLMEAEDDGFPFPTWMPNADRKLLGSATNANVKPNAIVAQDGSGQYKTIAAALAAYPKDLVGRYIINVKAGVYDEYITINKDQVNVFIYGDGPRKTTVT... | 125 |
A0A1S4DB76 | 2.3.2.26 | ACT_SITE 1062; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MYQFDAVNNRSTTVYNRSTTTTYKRRLDQIVSSESLAPSPIRMRKDQTLPPSPPIPVQFFVRLFPGGKTLVMRAHSTDPVEFIHHKIMTITGIPAVEQRLIYRGKQLQPEQTLADCGIQKDESMQLVGRLRSVDHPQARQLINGLISLIFDILKSKNPSIPSDSDGIIRMLVGFLTMTPKDTIEKAAEHIKIFISSSAPTALVMLYMSPDGANKFTADKSVRSFISSFKSMLPKRMYILCTPIVLQFCKLLRGAGLDDSLYKFCRSSLGDIVESTGILRRKATTGLLAVKDEIVSSESLVSSPVRMLKDLIRVQFFVRLF... | 65 |
P25765 | 3.2.1.14 | ACT_SITE 147; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MRALAVVAMVATAFLAAAVHAEQCGSQAGGAVCPNCLCCSQFGWCGSTSDYCGAGCQSQCSAAGCGGGGPTPPSGSGGSGVASIVSRSLFDQMLLHRNDAACPASNFYTYDAFVAAASAFPGFAAAGGDADTNKREVAAFLAQTSHETTGGWATAPDGPYAWGYCFKEENGGAAGPDYCQQSAQWPCAAGKKYYGRGPIQLSYNFNYGPAGQAIGADLLGDPDLVASDATVSFDTAFWFWMTPQSPKPSCHAVATGQWTPSADDQAAGRVPGYGVITNIINGGLECGHGEDDRVADRIGFYKRYCDILGVSYDANLDCYS... | 158 |
Q8F290 | 1.8.1.4 | ACT_SITE 451; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGICLNWGCIPTKALLESAHLLEKLHSAKEYGINLSDPKPDFAAIIRRSRNVADGMASGVEFLLNKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATGARARELPGLPFDSHTVLSSKTAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSFVKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLEEIGIFLQKGFVKTDTKYKTSVPHIYAIGDCNGPPLLAH... | 36 |
A0A9J7HUC7 | 3.1.1.4 | ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MVVFGATAPVVLLGFLVAASMSQPVDQPEDQPVDQLVDYPVDHLEGQPRSRAKRDLFSLSGVIRCVTGNSALLMYNNYGCFCGRGGGRGRPVDDIDRCCVAHDRCYALPTWFNALFVIYPYRCIGSKVTCTSRNWLRRSVCECDKALAECFARSVYNRRFKNYPYCGALQPEDPAVDTGKEPAVDAGKETPVDAGKDEKPWIGSGDGYDRFLSQRVRVGKRVIIGQWPL | 130 |
A0A2K3D1P1 | 1.1.1.37 | ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MASSTSSAMAKWAAQAARGFAAAAPSSGKGRKVAVLGAAGGIGQPLSMLMKMNSQVSSLSLYDIAGTPGVAADVSHINTKAQVKGFDKDGLAEALRGCDLVIIPAGVPRKPGMTRDDLFKINAGIVRDLVTAVGQHCPGAVLNIISNPVNSTVPIAAEQLKKMGVYDKRKVMGVTTLDVVRAKTFYAEKNGLDVASVDVPVVGGHAGVTILPLFSQATPKATMSAEVLDALTKRTQDGGTEVVQAKAGKGSATLSMAYAAALFADSCLRGLNGAPVVECTYVESTVTDAPYFASKVKLSTEGVDKIHDLGPLSDYEKAGL... | 5 |
F6Y7X8 | 2.7.11.1 | ACT_SITE 326; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 343; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MNYREQLMSRAVPGQFDDADSSDSGSMVSMETSKDAQAVSENSHQPLNEVDEEIQENDFEEYEDYDDDDDDWDWDDEVGKLTKGFSSSGGSNPQVNRQTNHLNSSKMSTPADKALRKFENKINLDKLNLADSVINKVTEKTRQKDADMYRVKDKADRATVEQVLDSRTRITLFKMLSRGIISQINGCISTGKEANVYHASTTDGENRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVQTWAEKEMRNLIRLNIAKIPCPEPIMLKHHVLVMSFIGKDDMPAPLLKNAQLSESKARELYLQVIQYMRRMYQDA... | 99 |
G7J4T5 | 3.5.1.98 | ACT_SITE 162; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MGSGEMGVAESGGASLPSIGADAMKRRVTYFYEPSIGDYYYGQGHPMKPHRIRMAHNLIIHYSLHRRMQINRPFAAAPEDIRRFHSDDYVEFLSSVSPEIVSDNSHSHYRQLKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVRLNRGDADIAINWAGGLHHAKKAEASGFCYVNDIVLGILELLKVHRRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKFGDFFPGTGHIKDTGVGPGKDYALNVPLNDGMDDENFRALFRPIMQKVMDVYQPDAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSFNVPLMVLG... | 184 |
Q0U1W6 | 1.11.1.6 | ACT_SITE 95; /evidence="ECO:0000256|PIRSR:PIRSR038927-1"; ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR038927-1" | MASQILATASHVADKAKEMTGVKNAKVAQLQADTKDVHDPKWKMTSDYGVKQNNTDDWLKVATEDQQGPMLLEDHFAREKIQRFDHERIPERVVHARGSGAFGKFTLFESAADVTSAGVLTDTSRETPVFLRFSTVLGSRGSADTVRDVRGFAVKFYTEEGNWDIVGNNIPVFFIQDSMKFPDVIHAGKPEPDNEMPQAQSAHNNFWDFQYMHPEATHMFFWAMSDRTIPRSYRMMQGFGVNTFTLTNDKGERSFVKFIFTPELGVHSFVWDEALKIAGQDPDFHRKDLWTAIENGAYPKWKFGIQVIPESKEHDFEFDI... | 13 |
H9GEE3 | 2.3.1.48 | ACT_SITE 890; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MVKLANPLYTEWILEAIQKVKRQKQRPSEERICHAVCVSHGLDKKSVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFLPVKVCDLSKPSKGSKGTCSELRNVDWNKLLRRGIEGLQEPNGSSLKNIEKYLRSQHDLAGIFNDPVFQRRLRLGAKRAVNNGRLLKEGPQYRVNYGILEGRGTSRYSSFPISLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCLELTTNVKALRWQCIECKTCSACRIQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKK... | 61 |
W5MNH5 | 2.7.10.2 | ACT_SITE 486; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000604-1" | HLVMADKVNELRFFYGNITREEAEDYLRQSGMSDGLYLLRQSRNYLGGFALSVAYSRQCYHYTIERELSGTYAIAGGKSHKTPSDVIDYHAQESDGLVCLLKKPCNRPRGMQPKVGPFEDLKEQLIKEYVQQTWNLRGAALEQAIISQRPQLEKMIATTAHEKMPWFHGCISREGSEPRLLQSPRINGKFLIRERDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPDGKKFDTLWQLVEHYSYKSDGLLRVLTEACPRPDFAAGSINIGPPRLPDHHPDTVYTIATNIYVECRIKNIRLRVISLLPSRGHAATAHQNTY... | 98 |
A0A2R6W884 | 3.2.1.52 | ACT_SITE 408; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MSSSSHRCNGKKYKSIEDEPVTSFPHLSINMLFRLYNEDSRVYGPVNPLLINKLRLQRAMAHQAVMCTSTSWSWTWRFIVFILILLQVAVADVFLWPEPQTVRWESGARIVLNPAFEISAPDHPELSSAVARYAALIRTERWYPVQVPRSVVITRKAGTDSEVVILNVFVVDLAADLQHGVDESYTIEISPTSSNASLSAGTVWGAMRGLETFSQLLRVAEPSANAPLYIERGVFISDKPNYPHRGILLDIARNFFPVEDIKRTIRALSHNKLNVLHLHITDAQSFPLEIKSEPDLAVKGSFGPQFIYYQEHVVDLVRYG... | 170 |
B2U8Z4 | 1.3.3.3 | ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MDTQAVRAYLLDLQDRITTAASALDGGTFVTDAWEKPPTERLRGSGRTRILEGGALLERGGVGFSHVMGDTLPPSATANRPELAGRGFEAMGVSLVFHPRNPYVPTVHMNVRCFVAVRSDAAPVWWFGGGMDLTPYYGFTEDASHFHRTCQGALAPYGDELYPRFKQWCDDYFYLKHRKEARGIGGIFFDDFAELGFERSFEMMRSVGDAFLPAWLPIAEQRHATAYGERERAFQAYRRGRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDWV | 27 |
Q6AUK5 | 1.8.4.12 | ACT_SITE 212; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126" | MGVQHLLKLRMASPHPHPHPGAPLAARPLSALASFFLARPSSTAAAPPPRHVTLSCSRPHCNHNQWAASRCRGTAGRRRLQVVVAMSSSAPPPPPGSVQKSEEEWEAILSPEQFRILRLKGTEYPGTGEYDKLFAEGVYECAGCGTPLYKSSTKFNSGCGWPAFYEGFPGAIARTPDPDGRRIEITCAACGGHLGHVFKGEGFNTPTDERHCVNSISLKFIPASEDSKL | 40 |
A0A8I6GL04 | 2.3.2.26 | ACT_SITE 879; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MATGLGEPIYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITP... | 65 |
A0A072TSM6 | 1.11.1.7 | ACT_SITE 117; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAPPLILPKLILLILVLCLLFQHKNHNKNTNSNANTFNSINIVPIHSFSSFPVSLSAINNSHVSESSSSDSSSNFLLEYDFYRDSCPHAEHIVRSTLHLLYKTNPALVPALIRLVFHDCFIQVHFSLERFTSNDSLKGFDVIETIKAKLEEACPGVVSCADILVLAARDSVVLAGGPFYPLNPGRRDGSNSFADIATDELPSPYADLTQTRASFKSRGFDEREMVTLLGAHSIGVIPCKFFENCLYNFSGTNEPDPSLDTQFLNVLRSKCNETDALSTSASAYSSHASPSSLVEEQQEITTDSGESLSNFGTLYYRRLLQ... | 14 |
B7PIM6 | 3.1.3.48 | ACT_SITE 376; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50" | IWPLVSCFCISTVCSARLEQTDEVPSVQIVTLTKLEDTRPTVSSGDARQQTAPTPATAQPRPGVRPAWLLALGVGAVLLLLLAGLCPLLAWWLQRKPLPSKGDPELWLGPPPAGGDTLPLQCVPTAVQSAGPSPLHRTRGLLERRGSNASLTLDLQRTGNSDKQGSGPYLASRRLTRAQLRSCLSNVAALHSEFWDIPMNHPERAAVPGCGGKNRYRSILPNEHSRVLLGPRGDYINANRLRGFKGARSAYIATQGPLPHTVADFWAMVWQERAPVIVMITNLVEDAKVKCEQYLPEGEPLRFGEIGVAVLRTTPRDGYT... | 149 |
A7T3N0 | 3.2.1.52 | ACT_SITE 312; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MRVTQLEICRIACFLISLYATGGNTERFSSGDTLWPLPRELEASGGPLPLSLAFTIQTSSESEILARGITRYLEIITTHLHTAARSRVNGSKELEVLRISVKSDDESLNEGTSYEYSLSFDSGPQATLTALTPYGALYGMETFSQLVVDGSLVYTSVSISDKPSFVHRGLMLDTGRRFFPMDLLYNTLDAMSYVKLNVLHFHLSDLCRFSVESKLFPDLRNNESEIYTQDDVRNLVAYARDRGIRVMPEVEGAAHANGLLGLKNKGLQFCNHSGYTQLYNDPQGNTLKTMKAILSEMVPLFPEQIFHLGLDEVFTDKNCT... | 170 |
I3LQZ5 | 2.7.11.1 | ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 702; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MGGAEPRSHQSEQPRSSLSCHPAKQQQFEERGGAAPEASERVVQWELALTDARALCPINDGGSNGSSILLAVGGAARRRRRPSRGRFGCAVLAVPAVGGGGEGASRAARAGKLLVSASEFWSRRIPASGAAAGAVKGWASAVSWVPSEDPAGSGKKKMEEEGGSSGGGAAGTSRDGGAGEEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV... | 99 |
Q7JW03 | 2.3.2.23 | ACT_SITE 87; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MSSPSAGKRRMDNDVIKLIESKHEVTILGGLNEFHVKFFGPTETPYEGGVWKVRVYLPDNYPFKSPSIGFVNKIYHPNIDESSGTVCLDVINQAWTALYDLSNIFESFLPQLLTYPNPVDPLNRDAAALYLHEPEEYHRKVADYVQRYATEDALRAAQQERESSDSESSMSDYSEDEARDMEL | 64 |
A0A1S4BB73 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASFSYLSILVLCILGIVSSGHAQLQLNFYAKSCPKAEKIIKDFVQKQVPKAPNTAAAILRMHFHDCFVRGCDGSVLLNFTSSTGNQTEKQANPNLTLRGFSFIDAVKRLVEAECPGIVSCADIIALVARDAVVVTGGPSWNVPTGRRDGRISNVSEANADIPAPTSNFTRLQQSFGKKGLDLNDLVLLSSAHTIGVSHCSSFSERLYNFTGILGTQDPSLDSEYADNLKSRKCKSINDNTTIVEMDPGSFKTFDLSYYKLLLKRRGLFQSDAALTKRTTTKSFIEQLVEGSLKEFYAEFAKAMEKMGRVEVKTGSAGEI... | 14 |
A0A251P8Z4 | 1.1.1.100 | ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAATIAFNAVGASGRLSRQLSHPRSSYPLLGRIRLHRVAPTRFSRSSSSSSGSAGIRAQVAAVEQSSAAVAQNVEAPVVIVTGASRGIGKAVALALGKSGCKVLVNYARSSKEAELVSKEIEASGGQALTFGGDVSNEEDVAAMIKTVVDAWGTVDVLVNNAGITRDGLLMRMKTSQWQEVIDLNLTGVFLCTQAAAKVMMKQRKGRIINIASVVGLVGNVGQANYSAAKAGVIGFTKSVAKEYSSRSINVNAVAPGFIASDMTAKLGEDIEKKILGTIPLGRYGQPEEVAGLVEFLALNPAASYITGQVLTIDGGMVM | 2 |
A0A3B6ISQ4 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTRWVPPLGLRFSLPLLLLLLAAAVIAPVHAYGKLKVGFYRQSCPDAEAIVRRIVTMAVEDDLTVTAPLLRLHFHDCFVRGCDGSVLLNSTKNNIAERDAKPNLTLDAFNVIDAIKEKLEEKCPGTVSCADILAVAARDAVSLATKVVTKGEWSEGGSLYEVETGRRDGRVSSAKEAAEELPDSFDEIQKLIKRFKSKGLGLKDLVVLSGAHALGNSHCPSLEKRLRNFTAEDDMDPTLDKAYAATLKQQCTSPDDNVTEVQMVPGRSTTFDSTYYRLVKENKGLFHSDEALLSNGATKMLVYGYMSSEKRFLKDFGVSM... | 14 |
A0A1U8FSJ6 | 3.1.1.11 | ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVMEWKEMGILTIMVMLWWSAGNCLKFDSTVAKDGSGKYKTIAAAINAAPKMRTKPYYIHVKRGIYYENVTIPYDKTNIALVGDGMGVTIISASKSSKRFPTPNTATLEVYGSGFIGMLMTIRNTAGAKNGQTAALTTAPFRGYASFFRCRFEGYQDTIFALDYAFFRGCHISGTIDFISGNGRAIFQKCSVEARKPIHGQEIRILAPGADNITSNPGIVLQNCKIYPEPGFNRSDGASFLGWPWKNQGKAVIMSSYINDFIDPKGWLSNPEVTNIYLAEYKNRGRGSNTRGRVKWSKVISGNEASKFTVRNFLQGEKWI... | 125 |
B3S8C0 | 3.1.3.48 | ACT_SITE 417; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50" | MATVLSTETAEIGISSSAVEEEMPVSSVIPSPPATEITITEYPNLPSFLPIYVSIRLAMNLETFEANKQEFKDNIAAYLNDNFNETFSNESVIIMNISRIATTNQRAGNDEVIVNFYITNDFAARSVNPTLTKFIGNWLLKLFQDRNDALLGPAFSGKLLQVSLILSNRVADGVVIAVTLSAFAAAILLIAFLYWRSSQTNSQMDKSVLAERLRSGSALRLEFDEIPTMVSSNAELPANIERKNRFINVVPNKLSRVNLRPILGDVTSEYINANYVRGYLGKPRSYIATQAPLTNTVTDFWRMIWENNVKVILMATALDI... | 149 |
F1NWE3 | 3.1.3.48 | ACT_SITE 1157; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"; ACT_SITE 1448; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MRILPSPGMPALLSLVSLLSVLLMGCVAESPPVFIKKPVDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENIYECVAQNPHGEVTVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSTSNGRIKQLRSGGLQIESSEETDQGKYECVASNSAGVRYSSPANLYVRELREVRRVAPRFSILPVSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKS... | 149 |
A0A3B6SV66 | 3.2.1.14 | ACT_SITE 145; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MRGLKMVAMLAMAAMVIGTVRAAQCGSKAGGATCPNCLCCSRYGWCGSTPEYCGDGCQSQFSGCGGGATPVSPNPTVGGVSSVISRSLFNQMLLHRNDPGCHARGFYTYDAFIAAVTAFPGFGTTGDTATRKREVAAFLAQTSHETTGEWPTAPNGPYAWGYCFKQEQNPTSNYCTPSTQWPCALGKSYYGRGPIQLSHNYNYGQAGRAIRADLLGNPNLVATNPTVSFKTVIWFWMTAQPPKPSSHAVITGQWKPSATDKAAGRVPGFGVITNIVNGGIECGHGHDNRVADRIGFYKRYCNIFGIGYGGNLDCYKQSPF... | 158 |
A0A9R0KB62 | 3.2.2.27 | ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MKIPGIIHFPTAIISKPSFSLSYSSFSRHYFYRYFPNNTINMAPSSSSKTLIDFFPQTNPKRRKTTDNGVSAAPLPPLSLLNSDNGDCGSGNPSDDTGLLTADQKFRMEFNKSLALSKLNLRICSDKVQNSKAEGGNGYVKLKELLVEESWLVALSEEFEKPYAKSLCKFVEAEICGGKVPIYPPPNLIFNALNSTSFDKVKAVILGQDPYHGPGQAMGLSFSVPKGIKIPSSLGNIFKELKQDLGCSIPSHGNLERWAVQGVLLLNTVLTVRNHQANSHAKKGWEQLTDAVIRNISEKRKGVVFILWGNCAQEKVRLID... | 173 |
A0A452E9Y6 | 1.11.1.7 | ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298" | MLVCLHLQVFLASVALFEVAASDTIAQAASTTTISDAVSKVKTQVNKAFLDSRTRLKTALSSEAPTTRQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRL... | 14 |
A0A9K3JXS4 | 3.1.1.11 | ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNTKRSILFWLSVTAIVLLSIYTKNPNIITSISLQSFKITSIKSVFDQSGSIHEFISFINQFLVRLYRLLVPCDESKWKSPLIAKYGVALTLTVDQKGCGKFTSLQKAVDAVPANSPKPTLIIVDAGQYREKVNVQKTKSNLIIQGKGFTNTFIIWHDTAAKSNGTVYSYSVGVFAPKFIAHDISFKNEAPLPSPGAIGGQAVAFRISGDQAAFYNCGFYGFQDTLFDDAGRHYFQNCFIEGTIDFIFGNGRSLYENCILNSVASGPGINGAIAAHQRASLQDKTGFSFVNCKIQGQGKIWLGRAWGVYSTTVYIRTFMP... | 125 |
A0A1S3Y0Y5 | 3.1.1.11 | ACT_SITE 380; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASHFSLPFLSFFLFVSLVSSSISQPPSPSPSPSPNIPIEIQGACKASRDPPTCEASILTDPSNLTPVQIILSALAVSSQNLTNAQSMVKNLLDTSAGNVNLTVAAKNCLLGFNYSAYRYNLTAAALPRGEIKDARAWMSAALGYQIGCSSNLLKVNETIQVAETLEVMNTLINFTTNALWMTVSYDIHGNDTGLWGPPKTERDGFWEPGSGSGFEFKGVVPSGLNPNVTVCKEGVCDYKMVQEAVNATPDNLGPWKFVIWIKAGLYDEIVRVPLEKRNVVFLGDGMGKTVITGSLSVGLVPGMTTYESATVGVSGDGFM... | 125 |
O22833 | 2.7.11.1 | ACT_SITE 460; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSRTIGSRVIFLILALFCCTENSRGKLVMQGSAGFFKGYRTLTSTKKHAYGQAFEDEIVPFKNSANDTVTSFSVTFFFAIAPEDKHKGAHGMAFVISPTRGITGASADQYLGIFNKANNGDSSNHVIAVELDINKDEEFGDINDNHVGININGMRSIKFAPAGYYDQEGQFKDLSLISGSLLRVTILYSQMEKQLNVTLSSPEEAYYPNKPLLSLNQDLSPYILENMYVGFSASTGSVRAMHYMLSWFVHGGVDVPNLDLGIPTFPPYPKEKSLVYRIVLVTSLALVLFVALVASALSIFFYRRHKKVKEVLEEWEIQCG... | 99 |
Q815K8 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 340; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSTIIDVYAREVLDSRGNPTVEVEVYTESGAFGRAIVPSGASTGEHEAVELRDGDKSRYLGKGVVNAVNNVNEIIAPEIAGFDVTDQAGIDRAMIELDGTPNKGKLGANAILGVSMAVAHAAADFVGLPLYRYLGGFNAKQLPTPMMNIINGGSHADNNVDFQEFMILPVGAPTFKESIRMGAEVFHALKAVLHDKGLNTAVGDEGGFAPNLGSNREALEVIIEAIEKAGYKAGENVFLGMDVASSEFYNKETGKYDLAGEGRTGLTSAEMVDFYEELCKDFPIISIEDGLDENDWDGHKLLTERIGDKVQLVGDDLFVT... | 200 |
Q9SCZ4 | 2.7.11.1 | ACT_SITE 661; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKITEGRFRLSLLLLLLLISAATLISAADYSPTEKILLNCGGGASNLTDTDNRIWISDVKSKFLSSSSEDSKTSPALTQDPSVPEVPYMTARVFRSPFTYTFPVASGRKFVRLYFYPNSYDGLNATNSLFSVSFGPYTLLKNFSASQTAEALTYAFIIKEFVVNVEGGTLNMTFTPESAPSNAYAFVNGIEVTSMPDMYSSTDGTLTMVGSSGSVTIDNSTALENVYRLNVGGNDISPSADTGLYRSWYDDQPYIFGAGLGIPETADPNMTIKYPTGTPTYVAPVDVYSTARSMGPTAQINLNYNLTWIFSIDSGFTYLV... | 99 |
Q9KG76 | 3.2.1.39 | ACT_SITE 466; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000305|PubMed:28781080"; ACT_SITE 542; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000305|PubMed:28781080"; ACT_SITE 546; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352" | MKGKNVQLLFALVVIILLFPTGASASPHAVSVGKGSYATEFPEIDFGGINDPGFRDQQGEPPATIYRSDRVTGPMQTNSWWGSLAVDRFSMNQYPHPFSVRHRAEGLHVFYDAPHNMVVHENREAGTWHIHGAIGTDFTIKHSGTANFEQAVVDDYNDWYVRGLLENGAHQMAITYGVGSPYIFVEYEDGSAVLDFDIAPDVWEMNGHVIGFSTHDHKHYAAFAPPGQNWSGIGSKTLTNNADYIAIAKLPEKDGNMLAKFEQYAYSVVRDAVADWTYDEATGTVTTTFEVTTEAKVQGAPDGTIFALYPHQYRHLASSS... | 167 |
A0A5F7ZIA6 | 2.7.10.1 | ACT_SITE 980; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MAESPASAFRDSLRKSVRTAAGNPGVPELGGTHPGLREEREKVKLGVATPRLVGMQLEGASWERACSQSQEEEEVEEEGCLRKYKNEVVELRFPSIGTGETRGAAWAAVRPFPRGSFRRRAPGPHPSPHPAPHALPAGSSRSHGAGAAVSTMELAAWYRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDLLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILW... | 97 |
Q89ZG8 | 2.7.7.7 | ACT_SITE 95; /evidence="ECO:0000256|HAMAP-Rule:MF_01113" | MDAFYASVEQRDHPELRGKPLAVGHAEERGVVAAASYEARRYGVRSAMSSQKAKRLCPQLIFVSGRMDVYKSVSRQIHEIFHEYTDIIEPLSLDEAFLDVTENKKGISLAVDIAKEIKLRIREQLNLVASAGVSYNKFLAKIASDYRKPDGLCTIHPDQALDFIAGLPIESFWGVGPVTAKKMHLLGIHNGLQLRKCSLEMLTAHFGKVGALYYECSRGIDERPVEAVRIRKSIGCERTLERDISVHSSVIIELYHVAVELIERLQRKEFKGNTLTLKIKFHDFSQITRSITQSQELYTLDRILPLAKELLKSVEYEQHP... | 121 |
Q89H18 | 3.2.1.21 | ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 431; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MSRPGRRNSASDLPQSSLLKPPATGHCAAAPASSRGQHHMSDKVSRRQFAALAGLSAAAIANPLDGADAKPAAAASRDSGFPEGFLWGTATSSYQVEGAVNEGGRGASIWDRFVRIPGKIEDGSTGDRANEHYHRYKEDIALIKELGCKAYRFSIAWPRVFPDGDGKPNPGGLDFYNRLVDELLKNGIEPWMTLYHWDLPQSLQDRFGGWRSTETCKIFGDYAAYVAERLTDRVKNVFTLNESGRFVQFGYGLGIDAPGVTLPQGEVNQVRHNSALAHGLAVQAVRAHGRRGTRVGPAENIDVCVPAIDTPEHVRAAEIA... | 161 |
Q9HFU4 | 5.3.1.8 | ACT_SITE 310; /evidence="ECO:0000250" | MSPSVFKISPGINSYDWGKKGSASLAAQLATTSIPDFSIDEDKAYAELWMGTHPNNPSRLSDNTLLSEHLKSHPELIGSSVSSKFEDCKDGSLPFLFKVLSIGTALSIQAHPDKPLAKKLFDEKPDVYKDPNHKPEMAIALTPFLAFLNFLPLSVLLLHLLTVPELQEFVDSSLTESLASSLGLPTSQPPDTSLFKPTESPATAEQKDILKQIFAALMSADKKLVEEAISKLIKRYQAKRDIKENEKSLVDLALRLNDQYPGDVGVLCVFLLNVVELKRGEAAFLGANEPHAYIEGDIIECMATSDNVVRAGLTPKLRDV... | 214 |
A0A061EPH4 | 3.1.1.11 | ACT_SITE 266; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MWTTKEFVGGPLKIEDPFPTNFSSQLMNIQFYLPTNCIPKKSSETSLKSFANLQKASSQLNLFTNMSWRFFRPMHLAFAAIVAVAICFPGCANGMSAERVIDSPLLTEKISTNRTIKVDLNGNGDFTSVQEAINSVPKGNSQWVIIHLRKGVYREKVHVPKDKPYIFLRGNGRGRTAIAWSQSSVDNKASATFTVEAKHFIAFGISFKNEAPTGIAYTSQNQSVAAFVGADMVAFYHCAFFSTHNTLFDYKGRHYYDNCYIQGSIDFIFGRGRSLFHNCEIFVLQDKRIKIRGSITAQNRGSPQDNSGFVFVEGKVYGIG... | 125 |
Q21017 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAPRRRMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIID... | 99 |
F1RGV0 | 2.7.11.25 | ACT_SITE 272; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MALPGAEGAVDRPGSPARGAPAASSSSSSASSGGSASASASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWTGQVQRRLGIFPANYVAPCRPAALPASPPARLPPPRPGSPVHVDFELLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLRQPHLCLVLEFARGGALNRALAAANAAPDPSAPGPRRPRRIPPHVLVNWAVQIAQGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDFCNKTLKITDFGLAREWHRTTRMSAAGTYAWM... | 105 |
Q0V2H0 | 3.1.3.16 | ACT_SITE 282; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MGNPQEEATALKNKGNDAFKNQDWPAALDFYTKAIELWDKEPSFYTNRAQANIKLESYGYAVADADKAIELDPNNVKAYYRRASANTSMLKHREALRDWKLVIKKAPNDANAKLRMHECEKIIKRDAFLKAIEVEDAPSAAEGLDIEHMALERNYDGPKLEGKMTLEFIEDMIERFKTGKKIAKKYAFQIILAVMDIVKNEPTMVEHKVEEGCEITVCGDTHGQYFDLLNIFKLAGKPSEKNHFLFNGDFVDRGSWSTEIALLLYAYKWLYPDKFFLNRGNHETDDMNRMYGFEGECRAKYNERMFKIFSESFSMLPLAT... | 144 |
A0A1D5QL11 | 2.7.10.1 | ACT_SITE 768; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MINCDYLCCHKKRQEQRWHRRTMAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSY... | 97 |
Q058B4 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLEYLKKYTTVVVDSGDINYIKKYQPNDATTNPTLILKSVLSNKYNYIIDNSIQYAKDIGGNKLTQVKNASDMISVGFGIEILKYIPGYISTEIDARLSFNTKKCVSKAIKLIKLYNNNGIDTSRVLIKLAATWECIEAARQLKKIGILCNLTLLFSFAQARACADADVFLISPFVGRIYDWYQKFNLNSPYCSNTDPGVIALKKIFFYYKKYGYKTIIMGASFRKLEQIQELVGCDRITISLDLLKQLSMKKDILIKKLDVKKITKVNTKPNALSESEFRFLHNEDAMAVEKLSEGIRQFSSDQQELENFLFDKL | 52 |
Q6DBX4 | 2.7.11.1 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEARGLACESSNSAVKAPSIEDFVLVKPISRGAFGKVYLARKKCNSKLYAIKVVKKAEMVDKNMTEQMRAERDALALSKSPFIVHLFYSLQTATKVYLVMEYLIGGDVKSLLHIYGYFDEDMSLKYISEVALALDYLHRHSIIHRDLKPDNMLISNEGHIKLTDFGLSKVKLDRELNLMDILTTPSLVKPTKDYFRTPGQVLSLISSLGLNTPVIEGKRHSSTVLGSPMSCGKVKQRNRSLGSPLMKRRAEYMNSPVCTSRALASNSVFSPVLLARSLTPRLLKSGKRLDTMSVGSTHSCMLPSTTDSENCVSPMWEDEQ... | 99 |
A8N936 | 6.5.1.1 | ACT_SITE 291; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MMQPTPAPSSAPGSPQRTQAEPEMETPSYPQPPQNVGTAPFSVLVKLFEKLATERKQERRRKLLDAWFRHWRREKGFDLYPVLRLLLPQKDRDRAVYGLKEKNLAKTYIKLIPLGMRDPDAIRLLNWKKPTERDKSSGDFPQVLCEVVSKRSSVIEGTLTIDELNEILDDIAKNMGKSDVQSKILRRIYNNSTADEQRWIIRIILKDMNISVKETTVFAVFHPDAQDLYNTCSDLKKVAWELWDPSRRLNAKDKEIQIFHAFAPMLCKRPTRKIEETVKAMGGSKFIIEEKLDGERMQLHKRGNEYFYCSRKGKDYTYLY... | 254 |
A0A059CEW5 | 6.3.4.4 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 117; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 217; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MYNLSSSISTSTRPGGAASPRDRLLLSGGGGGGGGGRRRAAFVVCSVKPPSATSSAATLAAPGQGKTEAAGRIAGLSQVSGVLGSQWGDEGKGKLVDILAQHFDVVARCQGGANAGHTIYNAEGKKFALHLVPSGILNEDTLCVIGNGVVVHLPGLFEEIDGLEAKGVSCKGRILLSDRSHLLFDFHQEVDGLREAELADSFIGTTKRGIGPCYSSKVIRNGIRVGDLRHMDTFPEKLDLLLSDAASRFPGFKYGPGMLEEEVERYKRFAERLEPFIADTVHVVNESILQKKKVLVEGGQATMLDIDFGTYPFVTSSSPS... | 253 |
P41571 | 1.1.1.49 | ACT_SITE 276; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P11411" | MATQHFTNGSATDDGETALEHIIKSLETPTMKCEGTHFDSHVPHTFVIFGASGDLAKKKIYPTLWWLYRDNLLPKSTKFCGYARSKLTIEELRAKCHQYMKVQPDEQAKYEEFWQNHDYAAGSYDQRSDFVALKERLSSLESCNCSCNRIFYLALPPSVFERVTVNIKDICLAERGWNRVIIEKPFGRDDVTSKKLSDHLASLFHEDQLYRIDHYLGKEMVQNLMTIRFANKILNSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPTSCQPDDIRDEKVKVLKSIPALTLDDMVLGQ... | 6 |
Q9R0A5 | 2.7.11.1 | ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQIIREYGEQILDEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCSHTE... | 99 |
M5X1V1 | 1.1.1.205 | ACT_SITE 320; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 416; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MSSSIFEDGFSSDRLFNQGYSYTYDDVIFLPHYIDFPTDSVHLATRLSRRVPLSIPCVSSPMDTVTEAHMAISMAALGGIGIIHSNTTPSEQAHMVKAVKSRRVPVLSNPVFKSPSDRIQSDDVFDSSNPYVLVTENGSPSSKLLGYVAGRDWATLGDKEVKIYDYMVNCTDFTVPWSYDLGRIGEHMEEKRRDVVATVRDDEVVDVVAKEEVERIKGYPKLGVGTVGPNGAWRVGAAIGTRETDKERLEGLVKAGVDVVVLDSSQGNSIYQIEMIKYVKKTYSNLDVVGGNVVTVSQAQNLIQAGVDGLRVGMGSGSIC... | 3 |
Q6CE12 | 2.1.1.33 | ACT_SITE 191; /evidence="ECO:0000255|HAMAP-Rule:MF_03055" | MLKRDQSEMDIEAETANMGKEEKESFVHKRQKYRQEQEEKRLAAKKGVSFEQPEDGEIKLPKKRYYRQRAHSNPFSDHQLEYPESPADMDWDVLYPNRKEGQKVEVADIGCGFGGLLVALSPQLPNQLILGMEIRVQVTNYVEDRIVALRHQNKETDGYQNISVLRGNAMKFLPNFFEKGQLSKIFFCFPDPHFKQRKHKARIVTTTLCSEYAYVVRPGGIVYTITDVKDLHEWMVKHLAAHPLFERLTKEEEDADPCVATMLVETEEGKKVARNEGDKFVACFRRKENPEW | 45 |
M4DEH4 | 1.11.1.7 | ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKAAVVSVLILLVIFVAWPVSADRKDLPGAGGYGGDEDDDNDTKSWFPLDNQLSLSYYDRICPDFEKIVATKVREWTKKDSSLGPALLRLLFHDCGVTGCDASVLLDHEGSERRSPASKTLRGFELIDDIKSEIEKACPGLVSCADILTAASRDATFQLGGPYWPNAYGRRDSTDSYARDVEKVPSGRRDITALLETFQSYGLNVLDLVVLSGAHTIGKAYCGTIQSRLYNFNATYGTDPSIDSKYADFLRRKCRVASETVYLDAATPVKFDNQYYINLQKNMGVLTTDQELVKDPRTAPLVKAFAEQPPHMFRQQFAVS... | 14 |
A9UUG1 | 3.4.19.12 | ACT_SITE 12; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 116; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MVYHERQESALCAQHALNSLLQGSFFSASDLGEIACQLDEEERSRYAEAGLDSRDLLNSFSGSQNCDDSGFFSSMTIERALQVWSLELIPRQSQRAVEAVRQPEQEQGFICNFDSHWLTLRRLSGQWWNLDSTLEQPEPMSDTYLGLYLQQLEQDGLHPPTHQLVLNPALQATPSLWSEARFQQVQGPHNRWIDKQYGMPGWLQYSAPMLKTLEAQALGEMSLLHDLNCG | 175 |
E1BMG4 | 2.7.11.13 | ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETDSFFALHHRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCQQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDSEHIFREGPVEIGL... | 100 |
Q89L91 | 3.2.1.21 | ACT_SITE 171; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 351; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MPTTQLPNTASLRPGFIWGVSTSSFQIEGATKEDGRGLSIWDIYCRSGEIKNHDTGDVACDHYHRYREDVGLMKTLGVQAYRFSVAWPRVLPLGLGSANEAGVSFYDRLIDELVAAGIEPWLCLYHWDLPQALEERGGWLNRESAAWFADYVTLIAARFGDRVKRFATFNEPSIFSLFSRSLGKREHSSEDKFHRMIHNVNLAHGAAVDVLRANVIGASIGCIHNRQPCRPSSASEADEAAAARLDVYWNAAFPDPQCRGEYPPSMRAAIEPHMQPGDLTRICRPLDWFGLNHYSPVYVKARADSMLGYDFGDKPASVPL... | 161 |
Q8DPM2 | 5.6.2.2 | ACT_SITE 120; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKM... | 222 |
Q8BY87 | 3.4.19.12 | ACT_SITE 197; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 503; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSERITLNLPASTPVRKLFEDVANKVGYINGTFDLTRENGVTTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLEDSNNVDDSVHDRFIGPLPREGSVASTNDYVSQNYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWR... | 175 |
A0A7M7N7J8 | 2.7.11.23 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MARNMLAGDRSKLYENIDFLGEGQFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVIGLLDCFGQRSNISLVFDFMETDLEVIIKDSSVVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYFYTKPAPTPGHLLPRPGMVAAAA... | 103 |
A0A8V0YGR1 | 2.7.10.1 | ACT_SITE 865; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000631-1" | MRSVRGAAGLLLLCGASFGLYFPRKEYSENVYIDQPAGAPLLRIHALRDSHGETAHFHLCQNLIISRARSHENHWFQIREKMGLLYLSKSLDREDFNMLSVGNWMPLSKVMLYVFLSSHPFQEKECDSATRTTVVLSLINATAPACSSLSARQLCFTEMDLSFHIKENKPPGTFHQLQLPSVHHLCQNLSITYKLLAAEGLPFRYNENTTGVSVTQRLDREERERYELIAKCTVREGFREMEVEVPFLVNVLDEDDSPPFLPNGTDTADAVVEFNRKEGTVLATLTVYDADTTPIYPLESSRKKYTGTIITDDPWINETF... | 97 |
A0A803T594 | 2.3.2.26 | ACT_SITE 1999; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSNRPNNSPGGSLRRSQRNTVGAQPQDDAVGGRSHLGQAKHKAQSPSESRKSISKAPKVQSNTTSEQPKGHFSKRGCSSSAIIIPQQEALETESTLERQKPGQVAKKDNPRGVKRSASPDYNQTNSPSPAKKTKALQHADSSSDLERNKPQTKSKKRHLHQEQESKSSQLPSTSKAHTRKGGATGSSRSQKRKKTETSSIVKSRPESAGSEERPAKVTKLASKSASSAKAGCSTITDSSSSASTSSSSSVVASASSGVPQGARVKQGKDQSKARRSRSASSPSPRRSSRDKEQNKIGGSSKFDWAARFSPKVTLPKTKLS... | 65 |
A0A804JS77 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAATSGFAAVFAIASLLCLTIAPTRGALQAGFYKGKCNGTDVEATVKSIVAARFAQDRSIVPALLRLHFHDCFVRGCDASILIDGSGTEKTAPPNLSVRGYDLVDQAKAQLESTCPGVVSCADIIAIATRDAVVLGGGTQYTYVVQTGRRDGNISLASDASANLPGASLSASQAIAAFRAKGLNASDTVLLLGGHTVGITHCSFILNRLYNYNGSGKPDPDMDPAFVAMLKSRCPQTSAVDNSVFLDNGTPSTVDNSYYKQLLAKRGVLKVDQNLAMDAATNGTVKSLASGSLSFPSLFGNAMVKMGSIQVLTGTQGQIR... | 14 |
O86616 | 3.2.1.23 | ACT_SITE 160; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 236; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MKRSTLSYTDGTLLRNGRPHRLLAGSLHYFRVHPGHWADRLRRLAALGLNAVDTYVPWNFHERTAGDIRFDGPRDLARFIRLAQEEGLDVVVRPGPYICAEWDNGGLPAWLTGTPGMRLRTSHGPYLEAVDRWFDALVPRIAELQAGRGGPVVAVQIENEYGSYGDDRAYVRHIRDALVARGITELLYTADGPTPLMQDGGALPGELAAATFGSRPDRAAALLRSRRPAEPFFCAEFWNGWFDHWGDKHHVRPAPSAAEDLGGILDEGGSVSLYMAHGGTNFGLWAGANHEGGTIRPTVTSYDSDAPIAENGALTPKFFA... | 163 |
P43293 | 2.7.11.1 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGGCFSNRIKTDIASSTWLSSKFLSRDGSKGSSTASFSYMPRTEGEILQNANLKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHNLVDWARPYLTNKRRLLRVMDPRLQGQYSLT... | 99 |
F6HRL7 | 2.3.2.26 | ACT_SITE 816; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MRKFDQNAFVSCNSPPDSHLERHRVVDARSCPSSCSAESARPDSRLQFFVRMISEGNTLVIHANSDDTVESLHHRIQSITGIPVMEQRLIYRGKQLQWEQSLAECSIQNDAGLQLVGRMRSTEHPAAWRVASEMVSTICRLCRGETFRPLKNIKSQLLEFLMLTPKDDTESAAGYLQVFMSSSAPSALVMLYMSPTKSNKETADDTIRQFLNSSRNLLPKSVQIQCVPIVLEFCKLLSRTDHEDPLYLTCRSTLGSLVENVGVVRASRYCHNSKTLIVVKEILPFVSELASSLSKSLISSMESAGSTGNSLNDGRNLIAG... | 65 |
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