question stringlengths 11 145 | answer stringlengths 2 565 | context_chunks sequence | document_id int64 650 2.63k | id int64 259 5.31k | context stringclasses 14
values |
|---|---|---|---|---|---|
What is IFITM? | interferon-induced transmembrane | [
"Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an important target for the activity against influenza A H1N1 virus infection. In this protein, a post-translational modification by fatty acids covalently attached to cysteine, termed S-palmitoylation, plays a crucial ... | 650 | 568 | Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an important target for the activity against influenza A H1N1 virus infection. In this protein, a post-translational modification by fatty acids covalently attached to cysteine, termed S-palmitoylation, plays a crucial role ... |
How many cysteine residues are contained in the first transmembrane domain of IFITM3? | three | [
"Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an important target for the activity against influenza A H1N1 virus infection. In this protein, a post-translational modification by fatty acids covalently attached to cysteine, termed S-palmitoylation, plays a crucial ... | 650 | 569 | Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an important target for the activity against influenza A H1N1 virus infection. In this protein, a post-translational modification by fatty acids covalently attached to cysteine, termed S-palmitoylation, plays a crucial role ... |
What inhibits S-palmitoylation? | 2-bromopalmitic acid (2BP) | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 570 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What interaction is inhibited by the presence of 2-bromopalmitic acid (2BP)? | IFITM5 with FKBP11 | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 571 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What is a function associated with IFITM5? | bone formation factor. | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 572 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What regulates the antiviral activity of IFITM3? | S-palmitoylation on the protein | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 573 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What is another name for IFITM5? | bonerestricted IFITM-like (BRIL) protein | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 574 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
Why is the expression of IFITM5 not promoted by interferons? | the region upstream of the ifitm5 gene lacks the interferon regulatory elements | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 575 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What is the amino acid similarity between IFITM5 and the other IFITM proteins? | ~ 65% similarity | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 576 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
What is the amino acid similarity between IFITM 1, IFITM 2, and IFITM 3? | ~ 85% similarity | ["Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an(...TRUNCATED) | 650 | 577 | "Recently, one of the interferon-induced transmembrane IFITM family proteins, IFITM3, has become an (...TRUNCATED) |
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