doi stringlengths 17 26 | title stringlengths 22 300 | abstract stringlengths 61 19.2k ⌀ | journal_eissn stringclasses 12
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10.3389/fonc.2019.01452 | Association Between the Microsatellite Instability Status and the Efficacy of Postoperative Adjuvant Chemoradiotherapy in Patients With Gastric Cancer | Purpose: The effect of microsatellite instability (MSI) on the response to radiotherapy remains unknown. The aim of this study was to investigate the association between the MSI status and the outcomes of gastric cancer (GC) treated by surgical resection with or without postoperative adjuvant chemoradiotherapy. Methods... | 2234943X | ONCOLOGY |
10.3389/feduc.2019.00153 | Developing a Short Form of the Self-Assessment Practices Scale: Psychometric Evidence | This research aimed to develop a short form of the Self-assessment Practices Scale (SaPS). Guided by a process model of self-assessment, the SaPS scale was designed to assess the actions students engage in during the self-assessment process. The data used for developing the original 20-item SaPS (SaPS-20), i.e., 1,416 ... | 2504284X | EDUCATION |
10.3389/fonc.2019.01510 | Non-invasive Molecular Detection of Minimal Residual Disease in Papillary Thyroid Cancer Patients | Background: Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy. Serum thyroglobulin (Tg) levels are used to monitor PTC treatment response and recurrences however, in about 25% of the cases the sensitivity of this method is compromised due to either the presence of neutralizing anti-Tg antibod... | 2234943X | ONCOLOGY |
10.3390/ejihpe10010029 | Measuring Heart Rate Variability Using Commercially Available Devices in Healthy Children: A Validity and Reliability Study | Heart rate variability (HRV) is an accepted method for determining autonomic nervous system activity and cardiovascular risk in various populations. This study assessed the validity and reliability of a commercially available finger photoplethysmography (PPG) system for measuring pediatric HRV in a real-world setting. ... | 22549625 | PSYCHOLOGY |
10.3390/cancers12010182 | Predictors of Response and Survival in Immune Checkpoint Inhibitor-Treated Unresectable Hepatocellular Carcinoma | Immune checkpoint inhibitors (ICIs) with nivolumab and pembrolizumab are promising agents for advanced hepatocellular carcinoma (HCC) but lack of effective biomarkers. We aimed to investigate the potential predictors of response and factors associated with overall survival (OS) for ICI treatment in unresectable HCC pat... | 20726694 | ONCOLOGY |
10.3390/cancers12010223 | MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer | Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) ... | 20726694 | ONCOLOGY |
10.3389/fpsyg.2019.03033 | Life History and Multi-Partner Mating: A Novel Explanation for Moral Stigma Against Consensual Non-monogamy | Life history theory (LHT) predicts that individuals vary in their sexual, reproductive, parental, familial, and social behavior according to the physical and social challenges imposed upon them throughout development. LHT provides a framework for understanding why non-monogamy may be the target of significant moral con... | 16641078 | PSYCHOLOGY |
10.3389/frai.2019.00032 | Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery | Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery | 26248212 | AI |
10.3389/fpsyg.2019.03023 | The Emotional Stroop Effect Is Modulated by the Biological Salience and Motivational Intensity Inherent in Stimuli | Prior research has found significant emotional Stroop effects for negative stimuli, but the results have been inconsistent for positive stimuli. Combining an evolutionary perspective of emotion with the motivational dimensional model of affect, we speculated that the emotional Stroop effect of a stimulus may be influen... | 16641078 | PSYCHOLOGY |
10.3389/fonc.2019.01575 | A Novel LncRNA, AC091729.7 Promotes Sinonasal Squamous Cell Carcinomas Proliferation and Invasion Through Binding SRSF2 | Long non-coding RNAs (lncRNAs) play important roles in various biological progresses of carcinogenesis. However, the function of lncRNAs in human sinonasal squamous cell carcinoma (SNSCC) remains greatly unclear. In the current study, lncRNA AC091729.7 expression was examined in SNSCC samples by using microarray, RNA i... | 2234943X | ONCOLOGY |
10.3389/feduc.2020.00002 | Definitions of Formative Assessment Need to Make a Distinction Between a Psychometric Understanding of Assessment and “Evaluative Judgment” | Definitions of Formative Assessment Need to Make a Distinction Between a Psychometric Understanding of Assessment and “Evaluative Judgment” | 2504284X | EDUCATION |
10.3390/cancers12020325 | Mutation Analysis of Colorectal and Gastric Carcinomas Originating from Adenomas: Insights into Genomic Evolution Associated with Malignant Progression | Small malignant tumor foci arising from benign lesions are rare but offer a unique opportunity to investigate the genomic evolution that occurs during malignant transformation. In this study, we analyzed 11 colorectal and 10 gastric adenoma–carcinoma pairs, each of which represented malignant tumors (carcinomas) embedd... | 20726694 | ONCOLOGY |
10.1186/s40594-019-0201-4 | Defining interdisciplinary collaboration based on high school teachers’ beliefs and practices of STEM integration using a complex designed system | Background: Teachers’ beliefs play an important role in how teachers think about how students learn, and how content should be organized and taught. Integrated STEM is pushing the boundaries of some of the traditional assumptions in education—disciplined-based courses, courses taught independently by teachers, standard... | 21967822 | EDUCATION |
10.1186/s40359-020-0378-9 | The clinical effects of school sandplay group therapy on general children with a focus on Korea Child & Youth Personality Test | Background: This study intended to examine the comprehensive clinical effects of school sandplay group counseling on the emotions and behaviors of children for the first time in Korea. Methods: To this objective, 10 sessions of in-school sandplay group counseling were administered to 113 fourth- to sixth-graders in an ... | 20507283 | PSYCHOLOGY |
10.3389/fpsyg.2020.00013 | Influences of a Luck Game on Offers in Ultimatum and Dictator Games: Is There a Mediation of Emotions? | The ultimatum (UG) and dictator (DG) games are two tasks where a sum of money has to be divided between two players: a proposer and a receiver. Following the rational choice theory, proposers should offer the minimum in the UG and nothing in the DG, due to the presence/absence of the receivers’ bargaining power. The fa... | 16641078 | PSYCHOLOGY |
10.3390/ejihpe10010031 | The Organization of Self-Knowledge in Adolescence: Some Contributions Using the Repertory Grid Technique | (1) Background: This study aims to explore the usefulness of personal construct psychology as a comprehensive framework and assessment tool to embrace a diversity of self-knowledge organization constructs, and to account for developmental differences across adolescence. (2) Methods: The repertory grid technique was use... | 22549625 | PSYCHOLOGY |
10.3390/cancers12020379 | Uncovering Tumour Heterogeneity through PKR and nc886 Analysis in Metastatic Colon Cancer Patients Treated with 5-FU-Based Chemotherapy | Colorectal cancer treatment has advanced over the past decade. The drug 5-fluorouracil is still used with a wide percentage of patients who do not respond. Therefore, a challenge is the identification of predictive biomarkers. The protein kinase R (PKR also called EIF2AK2) and its regulator, the non-coding pre-mir-nc88... | 20726694 | ONCOLOGY |
10.3390/ai1010005 | Detection of Anomalies in Large-Scale Cyberattacks Using Fuzzy Neural Networks | The fuzzy neural networks are hybrid structures that can act in several contexts of the pattern classification, including the detection of failures and anomalous behaviors. This paper discusses the use of an artificial intelligence model based on the association between fuzzy logic and training of artificial neural net... | 26732688 | AI |
10.3389/fpsyg.2020.00123 | Virtual Reality for the Assessment of Everyday Cognitive Functions in Older Adults: An Evaluation of the Virtual Reality Action Test and Two Interaction Devices in a 91-Year-Old Woman | Performance-based functional tests for the evaluation of daily living activities demonstrate strong psychometric properties and solve many of the limitations associated with self- and informant-report questionnaires. Virtual reality (VR) technology, which has gained interest as an effective medium for administering int... | 16641078 | PSYCHOLOGY |
10.3389/fpsyg.2020.00133 | Trajectories of Development and Socialization of Trans Brazilian Youth Through Self-Portraits | The aim of this research was to explore the meanings of childhood memory established by young people who identify themselves as trans. In a chauvinistic country such as Brazil, sexual socialization of non-cisgender youth is beset by unique challenges, such as discrimination and violence. This study was based on the pro... | 16641078 | PSYCHOLOGY |
10.1186/s40359-020-0383-z | The relationship between personality traits and marital satisfaction: a systematic review and meta-analysis | Background: Personality traits can be used to predict an individual’s behaviors in different life situations, including marital life situations. Marital satisfaction that is influenced by different factors is a criterion used to assess couples’ relationship quality. The goal of the present study was to review Iranian s... | 20507283 | PSYCHOLOGY |
10.1186/s40594-019-0199-7 | The use and effectiveness of colorful, contextualized, student-made material for elementary mathematics instruction | Background: There is anecdotal evidence that many elementary teachers integrate mathematics lessons and art activities by having students first make colorful, rich material that is subsequently used in an instructional activity. However, it is unclear whether such activities effectively promote learning and transfer of... | 21967822 | EDUCATION |
10.3389/feduc.2020.00009 | Difficulty of Summarization Items for Japanese Learners: Effects of Passages, Distractors, and Response Formats | This study aims to examine factors affecting the difficulty of summarization items for Japanese learners. In the process of item development, creating a connection between cognitive features related to target construct and the difficulty of test items is necessary to define the abilities to be measured. Previous studie... | 2504284X | EDUCATION |
10.3389/feduc.2019.00165 | Contrast and Assimilation Effects on Self-Evaluation of Performance and Task Interest in a Sample of Elementary School Children | Social comparison processes and the social position within a school class already play a major role in performance evaluation as early as in elementary school. The influence of contrast and assimilation effects on self-evaluation of performance as well as task interest has been widely researched in observational studie... | 2504284X | EDUCATION |
10.3389/fpsyg.2020.00143 | Metacognitive Therapy for Adjustment Disorder in a Patient With Newly Diagnosed Pulmonary Arterial Hypertension: A Case Report | Adjustment disorders (ADs) belong to the worldwide most diagnosed mental disorders and are particularly frequent in patients with an underlying physical illness. Pulmonary arterial hypertension (PAH) is a severe and disabling disease, which significantly impacts on quality of life and has high mortality rates. The auth... | 16641078 | PSYCHOLOGY |
10.3389/fpsyg.2020.00225 | Southerners Are Wiser Than Northerners Regarding Interpersonal Conflicts in China | Initial evidence suggests that cultural differences have consequences for wise reasoning (perspective taking, consideration of change and alternatives, intellectual humility, search for compromise, and adopting an outsider’s vantage point), with more reports of wise reasoning about interpersonal conflicts among Japanes... | 16641078 | PSYCHOLOGY |
10.3389/fpsyg.2020.00038 | How Does Work Motivation Impact Employees’ Investment at Work and Their Job Engagement? A Moderated-Moderation Perspective Through an International Lens | This paper aims at shedding light on the effects that intrinsic and extrinsic motivation, as predictors, have on heavy work investment of time and effort and on job engagement. Using a questionnaire survey, this study conducted a moderated-moderation analysis, considering two conditional effects—worker’s status (workin... | 16641078 | PSYCHOLOGY |
10.3390/cancers12020503 | A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment | In this study, for the first time, we precisely assembled the poly-γ-benzyl-l-glutamate and an amphiphilic copolymer d-α-tocopherol polyethylene glycol succinate into a mixed micellar system for the embedment of the anticancer drug doxorubicin. Importantly, the intracellular drug-releasing behaviors could be controlled... | 20726694 | ONCOLOGY |
10.3389/feduc.2020.00018 | Three Flute Players’ Lived Experiences of Dalcroze Eurhythmics in Preparing Contemporary Music for Performance | This qualitative study presents an interpretative phenomenological analysis of the lived experiences of three flute players who practice Dalcroze Eurhythmics, an approach to teaching, learning, and understanding music through exploring various music-movement relationships in social, creative, and rigorous ways. Our res... | 2504284X | EDUCATION |
10.3389/fonc.2020.00192 | Clinico-Immunological Profile of a 67-Year-Old Woman Affected by HER2-Positive Breast Cancer and Autoimmune Dermatomyositis | A patient with HER2-positive early breast cancer (BC) developed dermatomyositis (DM), which disappeared after the first administration of adjuvant trastuzumab. No HER2 overexpression/amplification was observed in DM skin biopsies. Both BC and skin immune infiltrates were composed mostly of CD3+ T-lymphocytes. Interesti... | 2234943X | ONCOLOGY |
10.3389/fonc.2020.00212 | Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma | Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively studied in recent years. Investigating the pathogenesis and potential therapeutic strategies of OSCC is required to further progress in this field, and a suitable research animal model that reflects the intricacies of cancer biology ... | 2234943X | ONCOLOGY |
10.3390/educsci10030046 | An Experiential Online Training Approach for Underrepresented Engineering and Technology Students | Workforce pipelines are essential to sustain a productive workforce in an increasingly competitive, high-tech environment. Advanced automation, sensors, materials and data analytics will increase the need for highly skilled workers in the manufacturing (and manufactured construction) sector. Attracting and developing t... | 22277102 | EDUCATION |
10.1186/s40594-020-00206-7 | Exploring STEM postsecondary instructors’ accounts of instructional planning and revisions | Background: Local and national initiatives to improve the learning experiences of students enrolled in Science, Technology, Engineering, and Mathematics (STEM) courses have been on-going for a couple of decades with a heightened momentum within the last 10 years. However, recent large-scale studies have demonstrated th... | 21967822 | EDUCATION |
10.3390/ai1010006 | R-KG: A Novel Method for Implementing a Robot Intelligent Service | Aiming to solve the problem of environmental information being difficult to characterize when an intelligent service is used, knowledge graphs are used to express environmental information when performing intelligent services. Here, we specially design a kind of knowledge graph for environment expression referred to as... | 26732688 | AI |
10.1186/s40594-020-00205-8 | Conceptual framework of STEM based on Japanese subject principles | Background: School education should improve science, technology, engineering, and mathematics (STEM) ability not only in science and mathematics but also in technology and engineering. However, practice and research are being conducted without clear definitions and methods for STEM education. Moreover, the positioning ... | 21967822 | EDUCATION |
10.3390/ejihpe10010037 | The Role of Field Training in STEM Education: Theoretical and Practical Limitations of Scalability | In this article, we consider the features of the perception of student information in science, technology, engineering, and mathematics (STEM) education, in order to draw the attention of researchers to the topic of learning in practice through field training. The article shows the results of these studies in Russia an... | 22549625 | PSYCHOLOGY |
10.3390/cancers12030640 | Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells | Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemotherapy—all contribu... | 20726694 | ONCOLOGY |
10.3389/fonc.2020.00324 | Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk | Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that the crosstalk between tumor and immune cells takes center stage in cancer developme... | 2234943X | ONCOLOGY |
10.1186/s40594-020-00209-4 | Effects of school climate and teacher self-efficacy on job satisfaction of mostly STEM teachers: a structural multigroup invariance approach | Background: Identification and retention of effective teachers in STEM education play cardinal roles in teacher recruitment exercises worldwide. Studies on factors that characterize effective teachers have therefore gained popularity in recent times. Teacher self-efficacy, job satisfaction and school climate are among ... | 21967822 | EDUCATION |
10.1186/s40594-020-00207-6 | Research and trends in STEM education: a systematic review of journal publications | With the rapid increase in the number of scholarly publications on STEM education in recent years, reviews of the status and trends in STEM education research internationally support the development of the field. For this review, we conducted a systematic analysis of 798 articles in STEM education published between 200... | 21967822 | EDUCATION |
10.3389/fpsyg.2020.00356 | A Multiple-Baseline Evaluation of Acceptance and Commitment Therapy Focused on Repetitive Negative Thinking for Comorbid Generalized Anxiety Disorder and Depression | Repetitive negative thinking (RNT) is a core feature of generalized anxiety disorder (GAD) and depression. Recently, some studies have shown promising results with brief protocols of acceptance and commitment therapy (ACT) focused on RNT in the treatment of emotional disorders in adults. The current study analyzes the ... | 16641078 | PSYCHOLOGY |
10.1186/s40594-020-00210-x | Integrating science and engineering practices: outcomes from a collaborative professional development | Background: The Next Generation Science Standards accentuate engineering design along with scientific inquiry, emphasizing the relationship between scientific investigations and engineering design in solving problems and devising new ideas and technologies. The goal is for students to realize the importance of science ... | 21967822 | EDUCATION |
10.1186/s40594-020-00208-5 | Rubrics to assess critical thinking and information processing in undergraduate STEM courses | Background: Process skills such as critical thinking and information processing are commonly stated outcomes for STEM undergraduate degree programs, but instructors often do not explicitly assess these skills in their courses. Students are more likely to develop these crucial skills if there is constructive alignment b... | 21967822 | EDUCATION |
10.1186/s40359-020-0391-z | The use of a psychological testing instrument as an indicator of dissatisfaction with aesthetic dental treatment – a preliminary study | Background: The use of psychological testing to indicate the potential for dissatisfaction with dental treatment has many potential patient and clinician benefits but has been rarely investigated. The study aimed to explore the use of the Symptom Checklist-90-Revised (SCL-90-R) psychological testing instrument in descr... | 20507283 | PSYCHOLOGY |
10.3389/frai.2020.00009 | Toward a Taxonomy for Adaptive Data Visualization in Analytics Applications | Data analytics as a field is currently at a crucial point in its development, as a commoditization takes place in the context of increasing amounts of data, more user diversity, and automated analysis solutions, the latter potentially eliminating the need for expert analysts. A central hypothesis of the present paper i... | 26248212 | AI |
10.3390/educsci10030081 | Teacher Training in Intercultural Education: Teacher Perceptions | Background: The aim of the present study was to evaluate teacher perceptions on the training received in intercultural education. Methods: The article presents a quantitative, non- experimental and ex-post-facto type of research; directed to inquire about the perceptions of the teachers of primary education in Andalusi... | 22277102 | EDUCATION |
10.3390/cancers12030745 | A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy | The chemotherapeutics sorafenib and regorafenib inhibit shedding of MHC class I-related chain A (MICA) from hepatocellular carcinoma (HCC) cells by suppressing a disintegrin and metalloprotease 9 (ADAM9). MICA is a ligand for natural killer (NK) group 2 member D (NKG2D) and is expressed on tumor cells to elicit attack ... | 20726694 | ONCOLOGY |
10.3390/cancers12030755 | Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma | Risk factors including genetic effects are still being investigated in lung adenocarcinoma (LUAD). Mitochondria play an important role in controlling imperative cellular parameters, and anomalies in mitochondrial function might be crucial for cancer development. The mitochondrial genomic aberrations found in lung adeno... | 20726694 | ONCOLOGY |
10.3389/fonc.2020.00377 | Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize | Editorial on the Research Topic Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize Personalization of treatment based on biological markers is being utilized in clinical medicine with increasing frequency. This trend, despite an effort to identify possible common patterns, r... | 2234943X | ONCOLOGY |
10.3389/fpsyg.2020.00524 | Onlife Extremism: Dynamic Integration of Digital and Physical Spaces in Radicalization | This article argues that one should consider online and offline radicalization in an integrated way. Occasionally, the design of some counter-measure initiatives treats the internet and the “real” world as two separate and independent realms. New information communication technologies (ICTs) allow extremists to fuse di... | 16641078 | PSYCHOLOGY |
10.3389/fpsyg.2020.00443 | Discrepancy in Ratings of Shared Decision Making Between Patients and Health Professionals: A Cross Sectional Study in Mental Health Care | Background: A defined goal in mental health care is to increase the opportunities for patients to more actively participate in their treatment. This goal includes integrating aspects of user empowerment and shared decision-making (SDM) into treatment courses. To achieve this goal, more knowledge is needed about how pat... | 16641078 | PSYCHOLOGY |
10.1007/s00432-020-03190-1 | Attitude of cancer patients from online self-help groups towards physical activity | Purpose Physical activity (PA) is important for cancer patients during and after therapy with respect to reducing side effects and improving quality of life. The aim of the study was to examine how physically active German cancer patients are and to identify predictors for PA. In addition, patients were asked about the... | 14321335 | ONCOLOGY |
10.3389/fonc.2020.00416 | Inhibition of microRNA-155 Reduces Neuropathic Pain During Chemotherapeutic Bortezomib via Engagement of Neuroinflammation | As a chemotherapeutic agent, bortezomib (BTZ) is used for the treatment of multiple myeloma with adverse effect of painful peripheral neuropathy. Our current study was to determine the inhibitory effects of blocking microRNA-155 (miR-155) signal on BTZ-induced neuropathic pain and the underlying mechanisms. We employed... | 2234943X | ONCOLOGY |
10.3389/fpsyg.2020.00562 | The Gold Standard and the Pyrite Principle: Toward a Supplemental Frame of Reference | In medicine and social sciences, the phrase “gold standard” is often used to characterize an object or procedure described as unequivocally the best in its genre, against which all others should be compared. Examples of this usage are readily available in rigorously peer-reviewed publications, touted by test publishers... | 16641078 | PSYCHOLOGY |
10.3390/educsci10040105 | Analysis of Courses and Teacher Training Programs on Playful Methodology in Andalusia (Spain) | In this study we analyzed the primary teaching and training experiences that observe play as a didactic resource to facilitate learning, highlighting fundamental elements and characteristics. A descriptive analysis of the different programs and contents with respect to playful methodology proposed by the Ministry of Ed... | 22277102 | EDUCATION |
10.3390/ai1020008 | Artificial Intelligence (AI) or Intelligence Augmentation (IA): What Is the Future? | Artificial intelligence (AI) is a rapidly growing technological phenomenon that all industries wish to exploit to benefit from efficiency gains and cost reductions. At the macrolevel, AI appears to be capable of replacing humans by undertaking intelligent tasks that were once limited to the human mind. However, another... | 26732688 | AI |
10.3389/fpsyg.2020.00669 | Math Anxiety and Working Memory Updating: Difficulties in Retrieving Numerical Information From Working Memory | This study aimed to determine whether math anxiety was related to working memory (WM) updating performance and, specifically, to the retrieval and substitution components of updating. A set of WM updating (WMU) tasks that involve different retrieval and substitution requirements were administered to 114 university stud... | 16641078 | PSYCHOLOGY |
10.3389/fonc.2020.00528 | Response: Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer | Response: Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer | 2234943X | ONCOLOGY |
10.1186/s40594-020-00211-w | Increasing high school teachers self-efficacy for integrated STEM instruction through a collaborative community of practice | Background: Teachers can have a significant impact on student interest and learning in science, technology, engineering, and math (STEM) subjects and careers. Teacher self-efficacy can also significantly affect student learning. Researchers investigated the effects of teacher professional development and integrated STE... | 21967822 | EDUCATION |
10.3389/fonc.2020.00558 | Association of Body Composition With Survival and Treatment Efficacy in Castration-Resistant Prostate Cancer | Objectives: The association of body composition with survival and the efficacy of first-line treatment was investigated in patients with castration-resistant prostate cancer (CRPC). Methods: The records of CRPC patients treated with docetaxel or androgen receptor signaling inhibitors (ARSi) between 2005 and 2018 were r... | 2234943X | ONCOLOGY |
10.3389/fonc.2020.00475 | Delivery and Biosafety of Oncolytic Virotherapy | In recent years, oncolytic virotherapy has emerged as a promising anticancer therapy. Oncolytic viruses destroy cancer cells, without damaging normal tissues, through virus self-replication and antitumor immunity responses, showing great potential for cancer treatment. However, the clinical guidelines for administering... | 2234943X | ONCOLOGY |
10.3390/cancers12041003 | Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs | Immunotherapeutic and targeted drugs improved survival of patients with metastatic melanoma. There is, however, a lack of evidence regarding their healthcare costs in clinical practice. The aim of our study was to provide insight into real-world healthcare costs of patients with metastatic cutaneous melanoma. Data were... | 20726694 | ONCOLOGY |
10.3389/frai.2020.00023 | PECLIDES Neuro: A Personalisable Clinical Decision Support System for Neurological Diseases | Neurodegenerative diseases such as Alzheimer's and Parkinson's impact millions of people worldwide. Early diagnosis has proven to greatly increase the chances of slowing down the diseases' progression. Correct diagnosis often relies on the analysis of large amounts of patient data, and thus lends itself well to support... | 26248212 | AI |
10.3389/feduc.2020.00038 | The MARquette Visualization Lab (MARVL): An Immersive Virtual Environment for Research, Teaching and Collaboration | The MARquette Visualization Lab (MARVL) is a large-scale immersive virtual environment for research, teaching, collaboration and outreach at our mid-sized liberal arts university. MARVL consists of multiple display surfaces including an extra wide front wall and floor, and two side walls. This resource includes stereos... | 2504284X | EDUCATION |
10.1186/s40594-020-00219-2 | Factors influencing participation of underrepresented students in STEM fields: matched mentors and mindsets | Background: Women and ethnic minorities remain underrepresented in science, technology, engineering, and math (STEM) fields. The goal of this pilot study is to better understand the beliefs and experiences of underrepresented US students pursuing STEM. Our focus was to gain insights into their mentorship experiences an... | 21967822 | EDUCATION |
10.3389/fpsyg.2020.00632 | “I Invest by Following Lead Investors!” The Role of Lead Investors in Fundraising Performance of Equity Crowdfunding | Psychological factors play a critical role in affecting investor decisions. This study explores how lead investors influence following investors psychologically, thus affecting fundraising performance of equity crowdfunding. We draw upon the signaling theory and observational learning theory to argue that following inv... | 16641078 | PSYCHOLOGY |
10.1186/s40594-020-00214-7 | Correlations between modes of student cognitive engagement and instructional practices in undergraduate STEM courses | Background: Within STEM education, research on instructional practices has focused on ways to increase student engagement and thereby reap the associated benefits of increased learning, persistence, and academic success. These meaningful-learning goals have been tied most specifically to cognitive engagement, a constru... | 21967822 | EDUCATION |
10.3390/ai1020010 | Deep Learning Based Wildfire Event Object Detection from 4K Aerial Images Acquired by UAS | Unmanned Aerial Systems, hereafter referred to as UAS, are of great use in hazard events such as wildfire due to their ability to provide high-resolution video imagery over areas deemed too dangerous for manned aircraft and ground crews. This aerial perspective allows for identification of ground-based hazards such as ... | 26732688 | AI |
10.3389/frai.2020.00024 | Learning to Play the Chess Variant Crazyhouse Above World Champion Level With Deep Neural Networks and Human Data | Deep neural networks have been successfully applied in learning the board games Go, chess, and shogi without prior knowledge by making use of reinforcement learning. Although starting from zero knowledge has been shown to yield impressive results, it is associated with high computationally costs especially for complex ... | 26248212 | AI |
10.3390/cancers12051099 | The Role of miRNA for the Treatment of MGMT Unmethylated Glioblastoma Multiforme | Glioblastoma multiforme (GBM) is the most common high-grade intracranial tumor in adults. It is characterized by uncontrolled proliferation, diffuse infiltration due to high invasive and migratory capacities, as well as intense resistance to chemo- and radiotherapy. With a five-year survival of less than 3% and an aver... | 20726694 | ONCOLOGY |
10.3389/fonc.2020.00658 | More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy? | The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known until recently. MTHFD2 is highly expressed in embryos and a wide range of tumors but has low or absent expression in most adult differentiated tissues... | 2234943X | ONCOLOGY |
10.3389/fonc.2020.00641 | Shaping Up the Tumor Microenvironment With Cellular Fibronectin | Normal tissue homeostasis and architecture restrain tumor growth. Thus for a tumor to develop and spread, malignant cells must overcome growth-repressive inputs from surrounding tissue and escape immune surveillance mechanisms that curb cancer progression. This is achieved by promoting the conversion of a physiological... | 2234943X | ONCOLOGY |
10.3390/cancers12051141 | Molecular Signatures of JMJD10/MINA53 in Gastric Cancer | The JMJD10 gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of JMJD10 in cancer is complex as it depends on the cancer type. In particular, the functional role of JMJD10/MINA53 in ga... | 20726694 | ONCOLOGY |
10.1007/s00432-020-03218-6 | Active HPV infection and its influence on survival in head and neck squamous-cell cancer | Purpose: HPV is involved in the development of some head and neck squamous-cell carcinomas (HNSCC). It was suggested that only transcriptionally active virus can induce carcinogenesis, therefore, the aim of our study was to analyze the frequency of active HPV infection, virus type, and its prognostic role in HNSCC pati... | 14321335 | ONCOLOGY |
10.3389/frai.2020.00028 | Predicting Biomass and Yield in a Tomato Phenotyping Experiment Using UAV Imagery and Random Forest | Biomass and yield are key variables for assessing the production and performance of agricultural systems. Modeling and predicting the biomass and yield of individual plants at the farm scale represents a major challenge in precision agriculture, particularly when salinity and other abiotic stresses may play a role. Her... | 26248212 | AI |
10.3389/frai.2020.00034 | On Consequentialism and Fairness | Recent work on fairness in machine learning has primarily emphasized how to define, quantify, and encourage “fair” outcomes. Less attention has been paid, however, to the ethical foundations which underlie such efforts. Among the ethical perspectives that should be taken into consideration is consequentialism, the posi... | 26248212 | AI |
10.3390/educsci10050134 | The Impact of Learning Strategies and Future Orientation on Academic Success: The Moderating Role of Academic Self-Efficacy among Italian Undergraduate Students | Promoting academic success among undergraduate students is crucial for tackling the need to foster employability competencies. Low levels of academic attainment in higher education, along with the increasing number of persons participating in tertiary education, represent crucial trends, which need to be studied in ord... | 22277102 | EDUCATION |
10.1007/s00432-020-03225-7 | Prognostic significance of VEGF and components of the plasminogen activator system in endometrial cancer | Objective The plasminogen activator system (PAS) and vascular endothelial growth factor (VEGF) are important in the carcinogenesis and play a key role in cancer invasion and mediating metastasis of carcinomas. The aim of the study was to evaluate the correlation of serum levels of VEGF and components of the PAS with cl... | 14321335 | ONCOLOGY |
10.3390/educsci10050137 | Tales from within: Gifted Students’ Lived Experiences with Teaching Practices in Regular Classrooms | Gifted students in regular classrooms have fewer opportunities to develop activities that are based on their characteristics as learners and address their needs; however, many of them spend most of their school time in these classrooms. The results presented here were part of a 2-year qualitative project that analyzed ... | 22277102 | EDUCATION |
10.3390/ai1020012 | Cities of the Future? The Potential Impact of Artificial Intelligence | Artificial intelligence (AI), like many revolutionary technologies in human history, will have a profound impact on societies. From this viewpoint, we analyze the combined effects of AI to raise important questions about the future form and function of cities. Combining knowledge from computer science, urban planning, ... | 26732688 | AI |
10.1186/s40594-020-00222-7 | Reducing withdrawal and failure rates in introductory programming with subgoal labeled worked examples | Background: Programming a computer is an increasingly valuable skill, but dropout and failure rates in introductory programming courses are regularly as high as 50%. Like many fields, programming requires students to learn complex problem-solving procedures from instructors who tend to have tacit knowledge about low-le... | 21967822 | EDUCATION |
10.3389/fonc.2020.00757 | Integration of Digital Pathologic and Transcriptomic Analyses Connects Tumor-Infiltrating Lymphocyte Spatial Density With Clinical Response to BRAF Inhibitors | Metastatic melanoma is one of the most immunogenic malignancies due to its high rate of mutations and neoantigen formation. Response to BRAF inhibitors (BRAFi) may be determined by intratumoral immune activation within melanoma metastases. To evaluate whether CD8+ T cell infiltration and distribution within melanoma me... | 2234943X | ONCOLOGY |
10.3389/frai.2020.00031 | Bringing Big Data to Bear in Environmental Public Health: Challenges and Recommendations | Understanding the role that the environment plays in influencing public health often involves collecting and studying large, complex data sets. There have been a number of private and public efforts to gather sufficient information and confront significant unknowns in the field of environmental public health, yet there... | 26248212 | AI |
10.3390/cancers12051273 | Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer | Sulforaphane exerts anti-cancer activity against multiple cancer types. Our objective was to evaluate utility of sulforaphane for endometrial cancer therapy. Sulforaphane reduced viability of endometrial cancer cell lines in association with the G2/M cell cycle arrest and cell division cycle protein 2 (Cdc2) phosphoryl... | 20726694 | ONCOLOGY |
10.1186/s40594-020-00217-4 | Measuring university students’ interest in biology: evaluation of an instrument targeting Hidi and Renninger’s individual interest | Background: Boosting students’ disciplinary interest has long been considered an important mechanism to increase student success and retention in STEM education. Yet, interest is a complex construct and can mean different things to different people, and many of the existing interest questionnaires do not identify a spe... | 21967822 | EDUCATION |
10.3389/fonc.2020.00633 | Long Non-coding RNA AK025387 Promotes Cell Migration and Invasion of Gastric Cancer | Gastric cancer is one of the most common cancers in the world, and long non-coding RNAs (lncRNAs) play a crucial role in proliferation, metastasis, and invasion of gastric cancer. However, there are very few researches focusing on the effects of lncRNAs on metastatic gastric cancer. In this research, we identify one ki... | 2234943X | ONCOLOGY |
10.3389/fonc.2020.00786 | Development and Validation of a Comprehensive Multivariate Dosimetric Model for Predicting Late Genitourinary Toxicity Following Prostate Cancer Stereotactic Body Radiotherapy | Purpose: Dosimetric predictors of toxicity after Stereotactic Body Radiation Therapy (SBRT) are not well-established. We sought to develop a multivariate model that predicts Common Terminology Criteria for Adverse Events (CTCAE) late grade 2 or greater genitourinary (GU) toxicity by interrogating the entire dose-volume... | 2234943X | ONCOLOGY |
10.3389/fonc.2020.00788 | The Landscape of Iron Metabolism-Related and Methylated Genes in the Prognosis Prediction of Clear Cell Renal Cell Carcinoma | Background: Clear cell renal cell carcinoma (ccRCC) is characteristics of resistance to chemotherapy and radiotherapy. The prognosis of ccRCC was dismay with immense diversity. Iron metabolism disturbance is a common phenomenon in ccRCC. The purpose of our study is to identify and validate the candidate prognostic gene... | 2234943X | ONCOLOGY |
10.3389/frai.2020.00035 | Implicit Standardization in a Minority Language Community: Real-Time Syntactic Change among Hasidic Yiddish Writers | The recent turn to “big data” from social media corpora has enabled sociolinguists to investigate patterns of language variation and change at unprecedented scales. However, research in this paradigm has been slow to address variable phenomena in minority languages, where data scarcity and the absence of computational ... | 26248212 | AI |
10.3390/cancers12061425 | A Phase 1 Study of mTORC1/2 Inhibitor BI 860585 as a Single Agent or with Exemestane or Paclitaxel in Patients with Advanced Solid Tumors | This phase 1 trial (NCT01938846) determined the maximum tolerated dose (MTD) of the mTOR serine/threonine kinase inhibitor, BI 860585, as monotherapy and with exemestane or paclitaxel in patients with advanced solid tumors. This 3+3 dose-escalation study assessed BI 860585 monotherapy (5–300 mg/day; Arm A), BI 860585 (... | 20726694 | ONCOLOGY |
10.1007/s00432-020-03275-x | Appropriate arrangement of cancer treatment after COVID-19 epidemic peaks in China | Purpose COVID-19 is causing a lot of problems in health services around the world, especially in medical institutions receiving cancer patients. On March 12, China’s National Health Commission announced that the peak of the COVID-19 epidemic has passed in China. Thus, a proper arrangement of medication, surgery and rad... | 14321335 | ONCOLOGY |
10.3389/feduc.2020.00053 | Form-Focused Instruction in the Heritage Language Classroom: Toward Research-Informed Heritage Language Pedagogy | In the context of adult second language teaching, heritage language speakers have been recognized as a special group of language learners, whose experience with their home language, as well as their motivations for (re)learning it, differ drastically from those of an average learner of a second language. Current herita... | 2504284X | EDUCATION |
10.3390/ai1020017 | Improving Daily Peak Flow Forecasts Using Hybrid Fourier-Series Autoregressive Integrated Moving Average and Recurrent Artificial Neural Network Models | In multi-purpose reservoirs, to achieve optimal operation, sophisticated models are required to forecast reservoir inflow in both short- and long-horizon times with an acceptable accuracy, particularly for peak flows. In this study, an auto-regressive hybrid model is proposed for long-horizon forecasting of daily reser... | 26732688 | AI |
10.3390/cancers12061572 | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers | Transcription factors encoded by Homeobox (HOX) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of HOX gene expression plays key roles in the development of cancers. Their expression levels in cancers tend to differ based on tissu... | 20726694 | ONCOLOGY |
10.3390/educsci10070177 | Progression of Cognitive-Affective States During Learning in Kindergarteners: Bringing Together Physiological, Observational and Performance Data | It has been shown that combining data from multiple sources, such as observations, self-reports, and performance with physiological markers offers better insights into cognitive-affective states during the learning process. Through a study with 12 kindergarteners, we explore the role of utilizing insights from multiple... | 22277102 | EDUCATION |
10.3390/cancers12071782 | A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape | The mTOR inhibitor Rapamycin has tumor inhibitory properties; and it is also used as an immunosuppressive agent after organ transplantation. However, prolonged Rapamycin treatment re-activates Akt and can promote cancer growth. Honokiol is a natural compound with both anti-tumorigenic and anti-inflammatory properties. ... | 20726694 | ONCOLOGY |
10.1007/s00432-020-03298-4 | Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas | Purpose: The aim of this study was to investigate DNA methylation alterations in non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinomas (HCCs). Methods: Genome-wide DNA methylation analysis was performed using the Infinium Human Methylation 450 K BeadChip, and levels of mRNA expression were analyzed by ... | 14321335 | ONCOLOGY |
10.3389/fonc.2020.01408 | Risk Factor Analysis of Acute Kidney Injury After Microwave Ablation of Hepatocellular Carcinoma: A Retrospective Study | Objectives:Acute kidney injury (AKI) is a recently observed side effect in patients after microwave ablation (MWA) of hepatocellular carcinoma (HCC) and is associated with negative outcomes. The aim of this study is to explore the risk factors of affecting the occurrence of AKI (stages 1b, 2, and 3), because they have ... | 2234943X | ONCOLOGY |
10.3389/frai.2020.00070 | Clustering and Recognition of Spatiotemporal Features Through Interpretable Embedding of Sequence to Sequence Recurrent Neural Networks | Encoder-decoder recurrent neural network models (RNN Seq2Seq) have achieved success in ubiquitous areas of computation and applications. They were shown to be effective in modeling data with both temporal and spatial dependencies for translation or prediction tasks. In this study, we propose an embedding approach to vi... | 26248212 | AI |
10.3389/fonc.2020.523577 | Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway | Cancer cachexia is a multifactorial syndrome characterized by continuous body wasting and loss of skeletal muscle. Impaired mitochondria function is closely associated with muscle atrophy in cancer cachexia. Our previous study confirmed the effectiveness of Baoyuan Jiedu decoction (BJD) in inhibiting cancer-induced mus... | 2234943X | ONCOLOGY |
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This articles were used in the publication Cite Lens: An AI Tool for Detecting Out-of-Scope and Out-of-Context Citations at TPDL 2025.
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